{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:28Z","timestamp":1790384308803,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":99,"publisher":"Springer New York","isbn-type":[{"value":"9781493972180","type":"print"},{"value":"9781493972197","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-7219-7_3","type":"book-chapter","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T10:48:19Z","timestamp":1502189299000},"page":"43-61","source":"Crossref","is-referenced-by-count":16,"title":["C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking"],"prefix":"10.1007","author":[{"given":"Kimberley","family":"Gauthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Rocheleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.phrs.2013.11.002","volume":"79","author":"R Roskoski Jr","year":"2014","unstructured":"Roskoski R Jr (2014) The ErbB\/HER family of protein-tyrosine kinases and cancer. Pharmacol Res 79:34\u201374. doi: 10.1016\/j.phrs.2013.11.002","journal-title":"Pharmacol Res"},{"issue":"5","key":"3_CR2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/cncr.24816","volume":"116","author":"MF Rimawi","year":"2010","unstructured":"Rimawi MF, Shetty PB, Weiss HL, Schiff R, Osborne CK, Chamness GC, Elledge RM (2010) Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes. Cancer 116(5):1234\u20131242. doi: 10.1002\/cncr.24816","journal-title":"Cancer"},{"issue":"13","key":"3_CR3","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1056\/NEJMra0802714","volume":"359","author":"RS Herbst","year":"2008","unstructured":"Herbst RS, Heymach JV, Lippman SM (2008) Lung cancer. N Engl J Med 359(13):1367\u20131380. doi: 10.1056\/NEJMra0802714","journal-title":"N Engl J Med"},{"issue":"2","key":"3_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/ijc.21496","volume":"118","author":"H Shigematsu","year":"2006","unstructured":"Shigematsu H, Gazdar AF (2006) Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118(2):257\u2013262. doi: 10.1002\/ijc.21496","journal-title":"Int J Cancer"},{"issue":"2","key":"3_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/35052073","volume":"2","author":"Y Yarden","year":"2001","unstructured":"Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2(2):127\u2013137. doi: 10.1038\/35052073","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/978-3-319-24223-1_7","volume":"893","author":"A Ahsan","year":"2016","unstructured":"Ahsan A (2016) Mechanisms of resistance to EGFR tyrosine kinase inhibitors and therapeutic approaches: an update. Adv Exp Med Biol 893:137\u2013153. doi: 10.1007\/978-3-319-24223-1_7","journal-title":"Adv Exp Med Biol"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.pharmthera.2016.03.002","volume":"161","author":"M Kuwano","year":"2016","unstructured":"Kuwano M, Sonoda K, Murakami Y, Watari K, Ono M (2016) Overcoming drug resistance to receptor tyrosine kinase inhibitors: learning from lung cancer. Pharmacol Ther 161:97\u2013110. doi: 10.1016\/j.pharmthera.2016.03.002","journal-title":"Pharmacol Ther"},{"issue":"938","key":"3_CR8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1098\/rstb.1976.0084","volume":"275","author":"JE Sulston","year":"1976","unstructured":"Sulston JE (1976) Post-embryonic development in the ventral cord of Caenorhabditis elegans. Philos Trans R Soc Lond Ser B Biol Sci 275(938):287\u2013297","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"3_CR9","doi-asserted-by":"publisher","unstructured":"Corsi AK, Wightman B, Chalfie M A transparent window into biology: a primer on Caenorhabditis elegans. WormBook. doi: 10.1895\/wormbook.1.177.1 . WormBook","DOI":"10.1895\/wormbook.1.177.1"},{"issue":"1","key":"3_CR10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","volume":"56","author":"JE Sulston","year":"1977","unstructured":"Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56(1):110\u2013156","journal-title":"Dev Biol"},{"issue":"5","key":"3_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020085","volume":"6","author":"DD Shaye","year":"2011","unstructured":"Shaye DD, Greenwald I (2011) OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One 6(5):e20085. doi: 10.1371\/journal.pone.0020085","journal-title":"PLoS One"},{"issue":"5","key":"3_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrd2031","volume":"5","author":"T Kaletta","year":"2006","unstructured":"Kaletta T, Hengartner MO (2006) Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov 5(5):387\u2013398. doi: 10.1038\/nrd2031","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"3_CR13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/hmg\/9.6.869","volume":"9","author":"E Culetto","year":"2000","unstructured":"Culetto E, Sattelle DB (2000) A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum Mol Genet 9(6):869\u2013877","journal-title":"Hum Mol Genet"},{"issue":"1","key":"3_CR14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"S Brenner","year":"1974","unstructured":"Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77(1):71\u201394","journal-title":"Genetics"},{"key":"3_CR15","doi-asserted-by":"publisher","unstructured":"Stiernagle T Maintenance of C. elegans. WormBook. doi: 10.1895\/wormbook.1.101.1 . WormBook","DOI":"10.1895\/wormbook.1.101.1"},{"issue":"6303","key":"3_CR16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/348693a0","volume":"348","author":"RV Aroian","year":"1990","unstructured":"Aroian RV, Koga M, Mendel JE, Ohshima Y, Sternberg PW (1990) The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348(6303):693\u2013699. doi: 10.1038\/348693a0","journal-title":"Nature"},{"issue":"3","key":"3_CR17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.devcel.2003.08.001","volume":"5","author":"M Shelly","year":"2003","unstructured":"Shelly M, Mosesson Y, Citri A, Lavi S, Zwang Y, Melamed-Book N, Aroeti B, Yarden Y (2003) Polar expression of ErbB-2\/HER2 in epithelia. Bimodal regulation by Lin-7. Dev Cell 5(3):475\u2013486","journal-title":"Dev Cell"},{"key":"3_CR18","doi-asserted-by":"publisher","unstructured":"Sundaram MV (2013) Canonical RTK-Ras-ERK signaling and related alternative pathways. WormBook:1\u201338. doi: 10.1895\/wormbook.1.80.2","DOI":"10.1895\/wormbook.1.80.2"},{"issue":"8","key":"3_CR19","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.1091\/mbc.E04-03-0198","volume":"15","author":"X Yin","year":"2004","unstructured":"Yin X, Gower NJ, Baylis HA, Strange K (2004) Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Mol Biol Cell 15(8):3938\u20133949. doi: 10.1091\/mbc.E04-03-0198","journal-title":"Mol Biol Cell"},{"issue":"10","key":"3_CR20","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/nn1981","volume":"10","author":"C Buskirk Van","year":"2007","unstructured":"Van Buskirk C, Sternberg PW (2007) Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci 10(10):1300\u20131307. doi: 10.1038\/nn1981","journal-title":"Nat Neurosci"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"7380","DOI":"10.1038\/ncomms8380","volume":"6","author":"DM Freed","year":"2015","unstructured":"Freed DM, Alvarado D, Lemmon MA (2015) Ligand regulation of a constitutively dimeric EGF receptor. Nat Commun 6:7380. doi: 10.1038\/ncomms8380","journal-title":"Nat Commun"},{"issue":"1","key":"3_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.devcel.2010.12.004","volume":"20","author":"TP Zand","year":"2011","unstructured":"Zand TP, Reiner DJ, Der CJ (2011) Ras effector switching promotes divergent cell fates in C. elegans vulval patterning. Dev Cell 20(1):84\u201396. doi: 10.1016\/j.devcel.2010.12.004","journal-title":"Dev Cell"},{"issue":"4","key":"3_CR23","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(89)90103-7","volume":"58","author":"PW Sternberg","year":"1989","unstructured":"Sternberg PW, Horvitz HR (1989) The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 58(4):679\u2013693","journal-title":"Cell"},{"issue":"2","key":"3_CR24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1534-5807(04)00021-8","volume":"6","author":"N Chen","year":"2004","unstructured":"Chen N, Greenwald I (2004) The lateral signal for LIN-12\/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev Cell 6(2):183\u2013192","journal-title":"Dev Cell"},{"issue":"3 Pt 2","key":"3_CR25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0092-8674(85)90230-2","volume":"43","author":"I Greenwald","year":"1985","unstructured":"Greenwald I (1985) lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor. Cell 43(3 Pt 2):583\u2013590","journal-title":"Cell"},{"issue":"2","key":"3_CR26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","volume":"34","author":"IS Greenwald","year":"1983","unstructured":"Greenwald IS, Sternberg PW, Horvitz HR (1983) The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell 34(2):435\u2013444","journal-title":"Cell"},{"issue":"11\u201312","key":"3_CR27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0168-9525(91)90257-Q","volume":"7","author":"PW Sternberg","year":"1991","unstructured":"Sternberg PW, Horvitz HR (1991) Signal transduction during C. elegans vulval induction. Trends Genet 7(11\u201312):366\u2013371","journal-title":"Trends Genet"},{"key":"3_CR28","doi-asserted-by":"publisher","unstructured":"Sternberg PW (2005) Vulval development. WormBook:1\u201328. doi: 10.1895\/wormbook.1.6.1","DOI":"10.1895\/wormbook.1.6.1"},{"issue":"6","key":"3_CR29","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0955-0674(97)80088-9","volume":"9","author":"SK Kim","year":"1997","unstructured":"Kim SK (1997) Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins. Curr Opin Cell Biol 9(6):853\u2013859","journal-title":"Curr Opin Cell Biol"},{"issue":"2","key":"3_CR30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-9525(97)01005-6","volume":"13","author":"K Kornfeld","year":"1997","unstructured":"Kornfeld K (1997) Vulval development in Caenorhabditis elegans. Trends Genet 13(2):55\u201361","journal-title":"Trends Genet"},{"issue":"6","key":"3_CR31","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0092-8674(00)81735-3","volume":"94","author":"SM Kaech","year":"1998","unstructured":"Kaech SM, Whitfield CW, Kim SK (1998) The LIN-2\/LIN-7\/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94(6):761\u2013771","journal-title":"Cell"},{"issue":"2","key":"3_CR32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(00)81096-X","volume":"85","author":"JS Simske","year":"1996","unstructured":"Simske JS, Kaech SM, Harp SA, Kim SK (1996) LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell 85(2):195\u2013204","journal-title":"Cell"},{"issue":"2","key":"3_CR33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/genetics\/96.2.435","volume":"96","author":"HR Horvitz","year":"1980","unstructured":"Horvitz HR, Sulston JE (1980) Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics 96(2):435\u2013454","journal-title":"Genetics"},{"issue":"4","key":"3_CR34","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/genetics\/126.4.899","volume":"126","author":"M Han","year":"1990","unstructured":"Han M, Aroian RV, Sternberg PW (1990) The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans. Genetics 126(4):899\u2013913","journal-title":"Genetics"},{"issue":"5","key":"3_CR35","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(90)90495-Z","volume":"63","author":"M Han","year":"1990","unstructured":"Han M, Sternberg PW (1990) let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63(5):921\u2013931","journal-title":"Cell"},{"issue":"6367","key":"3_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/356340a0","volume":"356","author":"SG Clark","year":"1992","unstructured":"Clark SG, Stern MJ, Horvitz HR (1992) C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356(6367):340\u2013344. doi: 10.1038\/356340a0","journal-title":"Nature"},{"issue":"6425","key":"3_CR37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/363133a0","volume":"363","author":"M Han","year":"1993","unstructured":"Han M, Golden A, Han Y, Sternberg PW (1993) C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363(6425):133\u2013140. doi: 10.1038\/363133a0","journal-title":"Nature"},{"issue":"6","key":"3_CR38","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0092-8674(95)90205-8","volume":"83","author":"M Sundaram","year":"1995","unstructured":"Sundaram M, Han M (1995) The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83(6):889\u2013901","journal-title":"Cell"},{"issue":"6","key":"3_CR39","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.9.6.756","volume":"9","author":"K Kornfeld","year":"1995","unstructured":"Kornfeld K, Guan KL, Horvitz HR (1995) The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev 9(6):756\u2013768","journal-title":"Genes Dev"},{"issue":"5","key":"3_CR40","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(02)00690-5","volume":"12","author":"M Ohmachi","year":"2002","unstructured":"Ohmachi M, Rocheleau CE, Church D, Lambie E, Schedl T, Sundaram MV (2002) C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr Biol 12(5):427\u2013433","journal-title":"Curr Biol"},{"issue":"2","key":"3_CR41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1006317206443","volume":"18","author":"C Chang","year":"1999","unstructured":"Chang C, Sternberg PW (1999) C. elegans vulval development as a model system to study the cancer biology of EGFR signaling. Cancer Metastasis Rev 18(2):203\u2013213","journal-title":"Cancer Metastasis Rev"},{"key":"3_CR42","series-title":"Cold Spring Harbor monographs","volume-title":"The nematode Caenorhabditis elegans","author":"J Sulston","year":"1988","unstructured":"Sulston J, Hodgkin J (1988) Methods. In: Wood WB (ed) The nematode Caenorhabditis elegans, Cold Spring Harbor monographs, 1st edn. Cold Spring Harbor, New York","edition":"1st"},{"issue":"3","key":"3_CR43","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1091\/mbc.E04-10-0885","volume":"16","author":"DR Glodowski","year":"2005","unstructured":"Glodowski DR, Wright T, Martinowich K, Chang HC, Beach D, Rongo C (2005) Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization. Mol Biol Cell 16(3):1417\u20131426. doi: 10.1091\/mbc.E04-10-0885","journal-title":"Mol Biol Cell"},{"issue":"4","key":"3_CR44","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/genetics\/104.4.619","volume":"104","author":"C Trent","year":"1983","unstructured":"Trent C, Tsuing N, Horvitz HR (1983) Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104(4):619\u2013647","journal-title":"Genetics"},{"issue":"Suppl 1","key":"3_CR45","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S0925-4773(03)00117-5","volume":"119","author":"T Inoue","year":"2002","unstructured":"Inoue T, Sherwood DR, Aspock G, Butler JA, Gupta BP, Kirouac M, Wang M, Lee PY, Kramer JM, Hope I, Burglin TR, Sternberg PW (2002) Gene expression markers for Caenorhabditis elegans vulval cells. Mech Dev 119(Suppl 1):S203\u2013S209","journal-title":"Mech Dev"},{"issue":"5","key":"3_CR46","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","volume":"44","author":"PW Sternberg","year":"1986","unstructured":"Sternberg PW, Horvitz HR (1986) Pattern formation during vulval development in C. elegans. Cell 44(5):761\u2013772","journal-title":"Cell"},{"key":"3_CR47","doi-asserted-by":"publisher","unstructured":"Yochem JK (2006) Nomarski images for learning the anatomy, with tips for mosaic analysis. WormBook:1\u201347. doi: 10.1895\/wormbook.1.100.1","DOI":"10.1895\/wormbook.1.100.1"},{"issue":"12","key":"3_CR48","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1242\/dev.125.12.2337","volume":"125","author":"LI Jiang","year":"1998","unstructured":"Jiang LI, Sternberg PW (1998) Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125(12):2337\u20132347","journal-title":"Development"},{"issue":"6","key":"3_CR49","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","volume":"125","author":"RD Burdine","year":"1998","unstructured":"Burdine RD, Branda CS, Stern MJ (1998) EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans. Development 125(6):1083\u20131093","journal-title":"Development"},{"issue":"5658","key":"3_CR50","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1126\/science.1091639","volume":"303","author":"AS Yoo","year":"2004","unstructured":"Yoo AS, Bais C, Greenwald I (2004) Crosstalk between the EGFR and LIN-12\/Notch pathways in C. elegans vulval development. Science 303(5658):663\u2013666. doi: 10.1126\/science.1091639","journal-title":"Science"},{"issue":"11","key":"3_CR51","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1101\/gad.333505","volume":"19","author":"TA Berset","year":"2005","unstructured":"Berset TA, Hoier EF, Hajnal A (2005) The C. elegans homolog of the mammalian tumor suppressor Dep-1\/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Genes Dev 19(11):1328\u20131340. doi: 10.1101\/gad.333505","journal-title":"Genes Dev"},{"key":"3_CR52","doi-asserted-by":"publisher","unstructured":"Ji N, van Oudenaarden A Single molecule fluorescent in situ hybridization (smFISH) of C. elegans worms and embryos. WormBook. doi: 10.1895\/wormbook.1.153.1 . WormBook","DOI":"10.1895\/wormbook.1.153.1"},{"issue":"10","key":"3_CR53","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nmeth.1253","volume":"5","author":"A Raj","year":"2008","unstructured":"Raj A, van den Bogaard P, Rifkin SA, van Oudenaarden A, Tyagi S (2008) Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods 5(10):877\u2013879. doi: 10.1038\/nmeth.1253","journal-title":"Nat Methods"},{"key":"3_CR54","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1038\/ncomms8053","volume":"6","author":"JS Zon van","year":"2015","unstructured":"van Zon JS, Kienle S, Huelsz-Prince G, Barkoulas M, van Oudenaarden A (2015) Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression. Nat Commun 6:7053. doi: 10.1038\/ncomms8053","journal-title":"Nat Commun"},{"issue":"4","key":"3_CR55","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/genetics\/139.4.1553","volume":"139","author":"GD Jongeward","year":"1995","unstructured":"Jongeward GD, Clandinin TR, Sternberg PW (1995) sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics 139(4):1553\u20131566","journal-title":"Genetics"},{"issue":"20","key":"3_CR56","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1101\/gad.11.20.2715","volume":"11","author":"A Hajnal","year":"1997","unstructured":"Hajnal A, Whitfield CW, Kim SK (1997) Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev 11(20):2715\u20132728","journal-title":"Genes Dev"},{"issue":"2","key":"3_CR57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1101\/gad.8.2.160","volume":"8","author":"MR Lackner","year":"1994","unstructured":"Lackner MR, Kornfeld K, Miller LM, Horvitz HR, Kim SK (1994) A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes Dev 8(2):160\u2013173","journal-title":"Genes Dev"},{"issue":"2","key":"3_CR58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/gad.8.2.147","volume":"8","author":"Y Wu","year":"1994","unstructured":"Wu Y, Han M (1994) Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev 8(2):147\u2013159","journal-title":"Genes Dev"},{"issue":"6","key":"3_CR59","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1101\/gad.9.6.742","volume":"9","author":"Y Wu","year":"1995","unstructured":"Wu Y, Han M, Guan KL (1995) MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev 9(6):742\u2013755","journal-title":"Genes Dev"},{"issue":"6","key":"3_CR60","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(95)90204-X","volume":"83","author":"M Therrien","year":"1995","unstructured":"Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (1995) KSR, a novel protein kinase required for RAS signal transduction. Cell 83(6):879\u2013888","journal-title":"Cell"},{"issue":"1","key":"3_CR61","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/genetics\/123.1.109","volume":"123","author":"EL Ferguson","year":"1989","unstructured":"Ferguson EL, Horvitz HR (1989) The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics 123(1):109\u2013121","journal-title":"Genetics"},{"issue":"12","key":"3_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002418","volume":"7","author":"AM Saffer","year":"2011","unstructured":"Saffer AM, Kim DH, van Oudenaarden A, Horvitz HR (2011) The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet 7(12):e1002418. doi: 10.1371\/journal.pgen.1002418","journal-title":"PLoS Genet"},{"issue":"4","key":"3_CR63","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/genetics\/137.4.987","volume":"137","author":"SG Clark","year":"1994","unstructured":"Clark SG, Lu X, Horvitz HR (1994) The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 137(4):987\u2013997","journal-title":"Genetics"},{"issue":"4","key":"3_CR64","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1091\/mbc.5.4.395","volume":"5","author":"LS Huang","year":"1994","unstructured":"Huang LS, Tzou P, Sternberg PW (1994) The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell 5(4):395\u2013411","journal-title":"Mol Biol Cell"},{"issue":"1","key":"3_CR65","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.8.1.60","volume":"8","author":"J Lee","year":"1994","unstructured":"Lee J, Jongeward GD, Sternberg PW (1994) unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev 8(1):60\u201373","journal-title":"Genes Dev"},{"issue":"5227","key":"3_CR66","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.7652556","volume":"269","author":"CH Yoon","year":"1995","unstructured":"Yoon CH, Lee J, Jongeward GD, Sternberg PW (1995) Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 269(5227):1102\u20131105","journal-title":"Science"},{"issue":"4","key":"3_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036489","volume":"7","author":"O Skorobogata","year":"2012","unstructured":"Skorobogata O, Rocheleau CE (2012) RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS One 7(4):e36489. doi: 10.1371\/journal.pone.0036489","journal-title":"PLoS One"},{"issue":"10","key":"3_CR68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004728","volume":"10","author":"O Skorobogata","year":"2014","unstructured":"Skorobogata O, Escobar-Restrepo JM, Rocheleau CE (2014) An AGEF-1\/Arf GTPase\/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genet 10(10):e1004728. doi: 10.1371\/journal.pgen.1004728","journal-title":"PLoS Genet"},{"issue":"23","key":"3_CR69","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1091\/mbc.E15-11-0757","volume":"27","author":"O Skorobogata","year":"2016","unstructured":"Skorobogata O, Meng J, Gauthier K, Rocheleau CE (2016) Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling. Mol Biol Cell 27(23):3771\u20133779. doi: 10.1091\/mbc.E15-11-0757","journal-title":"Mol Biol Cell"},{"issue":"1","key":"3_CR70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(05)00001-8","volume":"6","author":"NA Hopper","year":"2000","unstructured":"Hopper NA, Lee J, Sternberg PW (2000) ARK-1 inhibits EGFR signaling in C. elegans. Mol Cell 6(1):65\u201375","journal-title":"Mol Cell"},{"key":"3_CR71","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1471-213X-10-109","volume":"10","author":"GB Poulin","year":"2010","unstructured":"Poulin GB, Ahringer J (2010) The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells. BMC Dev Biol 10:109. doi: 10.1186\/1471-213X-10-109","journal-title":"BMC Dev Biol"},{"issue":"1","key":"3_CR72","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/genetics\/161.1.121","volume":"161","author":"CE Rocheleau","year":"2002","unstructured":"Rocheleau CE, Howard RM, Goldman AP, Volk ML, Girard LJ, Sundaram MV (2002) A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans. Genetics 161(1):121\u2013131","journal-title":"Genetics"},{"issue":"4","key":"3_CR73","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1534\/genetics.109.111591","volume":"184","author":"K Howell","year":"2010","unstructured":"Howell K, Arur S, Schedl T, Sundaram MV (2010) EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans. Genetics 184(4):899\u2013913. doi: 10.1534\/genetics.109.111591","journal-title":"Genetics"},{"issue":"33","key":"3_CR74","doi-asserted-by":"publisher","first-page":"11757","DOI":"10.1073\/pnas.0500937102","volume":"102","author":"CE Rocheleau","year":"2005","unstructured":"Rocheleau CE, Ronnlund A, Tuck S, Sundaram MV (2005) Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras\/Raf signaling. Proc Natl Acad Sci U S A 102(33):11757\u201311762. doi: 10.1073\/pnas.0500937102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"3_CR75","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.gene.2007.06.020","volume":"400","author":"H Qadota","year":"2007","unstructured":"Qadota H, Inoue M, Hikita T, Koppen M, Hardin JD, Amano M, Moerman DG, Kaibuchi K (2007) Establishment of a tissue-specific RNAi system in C. elegans. Gene 400(1\u20132):166\u2013173. doi: 10.1016\/j.gene.2007.06.020","journal-title":"Gene"},{"issue":"1","key":"3_CR76","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.devcel.2012.12.001","volume":"24","author":"M Barkoulas","year":"2013","unstructured":"Barkoulas M, van Zon JS, Milloz J, van Oudenaarden A, Felix MA (2013) Robustness and epistasis in the C. elegans vulval signaling network revealed by pathway dosage modulation. Dev Cell 24(1):64\u201375. doi: 10.1016\/j.devcel.2012.12.001","journal-title":"Dev Cell"},{"issue":"1","key":"3_CR77","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ydbio.2010.02.023","volume":"341","author":"K Fisher","year":"2010","unstructured":"Fisher K, Southall SM, Wilson JR, Poulin GB (2010) Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Dev Biol 341(1):142\u2013153. doi: 10.1016\/j.ydbio.2010.02.023","journal-title":"Dev Biol"},{"issue":"8","key":"3_CR78","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/ng1844","volume":"38","author":"B Lehner","year":"2006","unstructured":"Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38(8):896\u2013903. doi: 10.1038\/ng1844","journal-title":"Nat Genet"},{"issue":"6","key":"3_CR79","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1091\/mbc.10.6.2087","volume":"10","author":"CW Whitfield","year":"1999","unstructured":"Whitfield CW, Benard C, Barnes T, Hekimi S, Kim SK (1999) Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell 10(6):2087\u20132100","journal-title":"Mol Biol Cell"},{"issue":"5","key":"3_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004341","volume":"10","author":"A Haag","year":"2014","unstructured":"Haag A, Gutierrez P, Buhler A, Walser M, Yang Q, Langouet M, Kradolfer D, Frohli E, Herrmann CJ, Hajnal A, Escobar-Restrepo JM (2014) An in vivo EGF receptor localization screen in C. elegans identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. PLoS Genet 10(5):e1004341. doi: 10.1371\/journal.pgen.1004341","journal-title":"PLoS Genet"},{"key":"3_CR81","doi-asserted-by":"publisher","unstructured":"Duerr JS Immunohistochemistry. WormBook. doi: 10.1895\/wormbook.1.105.1 . WormBook","DOI":"10.1895\/wormbook.1.105.1"},{"issue":"5","key":"3_CR82","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(90)90493-X","volume":"63","author":"M Finney","year":"1990","unstructured":"Finney M, Ruvkun G (1990) The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63(5):895\u2013905","journal-title":"Cell"},{"issue":"6213","key":"3_CR83","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/338313a0","volume":"338","author":"G Ruvkun","year":"1989","unstructured":"Ruvkun G, Giusto J (1989) The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature 338(6213):313\u2013319. doi: 10.1038\/338313a0","journal-title":"Nature"},{"key":"3_CR84","doi-asserted-by":"publisher","unstructured":"Lant B, Derry WB (2014) Immunostaining for markers of apoptosis in the Caenorhabditis elegans germline. Cold Spring Harb Protoc 2014(5). doi: 10.1101\/pdb.prot080242","DOI":"10.1101\/pdb.prot080242"},{"issue":"3","key":"3_CR85","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.114.3.465","volume":"114","author":"R Francis","year":"1991","unstructured":"Francis R, Waterston RH (1991) Muscle cell attachment in Caenorhabditis elegans. J Cell Biol 114(3):465\u2013479","journal-title":"J Cell Biol"},{"issue":"11","key":"3_CR86","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/ncb1101-983","volume":"3","author":"M Koppen","year":"2001","unstructured":"Koppen M, Simske JS, Sims PA, Firestein BL, Hall DH, Radice AD, Rongo C, Hardin JD (2001) Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol 3(11):983\u2013991. doi: 10.1038\/ncb1101-983","journal-title":"Nat Cell Biol"},{"issue":"5","key":"3_CR87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020082","volume":"6","author":"E Zeiser","year":"2011","unstructured":"Zeiser E, Frokjaer-Jensen C, Jorgensen E, Ahringer J (2011) MosSCI and gateway compatible plasmid toolkit for constitutive and inducible expression of transgenes in the C. elegans germline. PLoS One 6(5):e20082. doi: 10.1371\/journal.pone.0020082","journal-title":"PLoS One"},{"key":"3_CR88","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/978-1-4939-2842-2_5","volume":"1327","author":"C Frokjaer-Jensen","year":"2015","unstructured":"Frokjaer-Jensen C (2015) Transposon-assisted genetic engineering with Mos1-mediated single-copy insertion (MosSCI). Methods Mol Biol 1327:49\u201358. doi: 10.1007\/978-1-4939-2842-2_5","journal-title":"Methods Mol Biol"},{"issue":"12","key":"3_CR89","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","volume":"10","author":"CC Mello","year":"1991","unstructured":"Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10(12):3959\u20133970","journal-title":"EMBO J"},{"key":"3_CR90","doi-asserted-by":"publisher","first-page":"e50773","DOI":"10.3791\/50773","volume":"82","author":"MC Mariol","year":"2013","unstructured":"Mariol MC, Walter L, Bellemin S, Gieseler K (2013) A rapid protocol for integrating extrachromosomal arrays with high transmission rate into the C. elegans genome. J Vis Exp 82:e50773. doi: 10.3791\/50773","journal-title":"J Vis Exp"},{"key":"3_CR91","doi-asserted-by":"publisher","unstructured":"Evans TC (2006) Transformation and microinjection. In: WormBook (ed) The C. elegans Research Community, WormBook, doi: 10.1895\/wormbook.1.108.1 ., http:\/\/www.wormbook.org","DOI":"10.1895\/wormbook.1.108.1"},{"issue":"3","key":"3_CR92","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/genetics\/157.3.1217","volume":"157","author":"V Praitis","year":"2001","unstructured":"Praitis V, Casey E, Collar D, Austin J (2001) Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157(3):1217\u20131226","journal-title":"Genetics"},{"issue":"4","key":"3_CR93","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)81186-1","volume":"93","author":"PB Tan","year":"1998","unstructured":"Tan PB, Lackner MR, Kim SK (1998) MAP kinase signaling specificity mediated by the LIN-1 Ets\/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93(4):569\u2013580","journal-title":"Cell"},{"issue":"3","key":"3_CR94","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1534\/genetics.115.182162","volume":"202","author":"DJ Dickinson","year":"2016","unstructured":"Dickinson DJ, Goldstein B (2016) CRISPR-based methods for Caenorhabditis elegans genome engineering. Genetics 202(3):885\u2013901. doi: 10.1534\/genetics.115.182162","journal-title":"Genetics"},{"issue":"4","key":"3_CR95","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1534\/genetics.114.166389","volume":"197","author":"H Kim","year":"2014","unstructured":"Kim H, Ishidate T, Ghanta KS, Seth M, Conte D Jr, Shirayama M, Mello CC (2014) A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics 197(4):1069\u20131080. doi: 10.1534\/genetics.114.166389","journal-title":"Genetics"},{"issue":"1","key":"3_CR96","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1534\/genetics.115.179382","volume":"201","author":"A Paix","year":"2015","unstructured":"Paix A, Folkmann A, Rasoloson D, Seydoux G (2015) High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9 ribonucleoprotein complexes. Genetics 201(1):47\u201354. doi: 10.1534\/genetics.115.179382","journal-title":"Genetics"},{"issue":"4","key":"3_CR97","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1534\/genetics.115.175166","volume":"199","author":"B Farboud","year":"2015","unstructured":"Farboud B, Meyer BJ (2015) Dramatic enhancement of genome editing by CRISPR\/Cas9 through improved guide RNA design. Genetics 199(4):959\u2013971. doi: 10.1534\/genetics.115.175166","journal-title":"Genetics"},{"issue":"9","key":"3_CR98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042441","volume":"7","author":"YK Bae","year":"2012","unstructured":"Bae YK, Sung JY, Kim YN, Kim S, Hong KM, Kim HT, Choi MS, Kwon JY, Shim J (2012) An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs. PLoS One 7(9):e42441. doi: 10.1371\/journal.pone.0042441","journal-title":"PLoS One"},{"issue":"7618","key":"3_CR99","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature19327","volume":"537","author":"NS Dhawan","year":"2016","unstructured":"Dhawan NS, Scopton AP, Dar AC (2016) Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature 537(7618):112\u2013116. doi: 10.1038\/nature19327","journal-title":"Nature"}],"container-title":["Methods in Molecular Biology","ErbB Receptor Signaling"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7219-7_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T18:17:17Z","timestamp":1692901037000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-7219-7_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493972180","9781493972197"],"references-count":99,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7219-7_3","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}