{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:02:25Z","timestamp":1784862145518,"version":"3.55.0"},"publisher-location":"New York, NY","reference-count":29,"publisher":"Springer New York","isbn-type":[{"value":"9781493972210","type":"print"},{"value":"9781493972234","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-7223-4_9","type":"book-chapter","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T11:54:40Z","timestamp":1502452480000},"page":"113-130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthetic Tumor-Specific Promoters for Transcriptional Regulation of Viral Replication"],"prefix":"10.1007","author":[{"given":"Maria Veronica","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo G.","family":"Cafferata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego L.","family":"Viale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo L.","family":"Podhajcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,12]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/cncr.26289","volume":"118","author":"J Xiong","year":"2012","unstructured":"Xiong J, Sun WJ, Wang WF, Liao ZK, Zhou FX, Kong HY, Xu Y, Xie CH, Zhou YF (2012) Novel, chimeric, cancer-specific, and radiation-inducible gene promoters for suicide gene therapy of cancer. Cancer 118:536\u2013548","journal-title":"Cancer"},{"issue":"11","key":"9_CR2","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1038\/jid.2013.191","volume":"133","author":"DL Viale","year":"2013","unstructured":"Viale DL, Cafferata EG, Gould D, Rotondaro C, Chernajovsky Y, Curiel DT, Podhajcer OL, Veronica Lopez M (2013) Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to melanoma microenvironment. J Invest Dermatol 133(11):2576\u20132584","journal-title":"J Invest Dermatol"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/cgt.2010.1","volume":"17","author":"RT Hogg","year":"2010","unstructured":"Hogg RT, Garcia JA, Gerard RD (2010) Adenoviral targeting of gene expression to tumors. Cancer Gene Ther 17:375\u2013386","journal-title":"Cancer Gene Ther"},{"issue":"3","key":"9_CR4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s10555-008-9135-x","volume":"27","author":"Osvaldo L. Podhajcer","year":"2008","unstructured":"Podhajcer OL, Benedetti L, Girotti MR, Prada F, Salvatierra E, Llera AS (2008) The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev 27(3):523\u2013537","journal-title":"Cancer and Metastasis Reviews"},{"key":"9_CR5","doi-asserted-by":"crossref","unstructured":"Lopez MV, Blanco P, Viale DL, Cafferata EG, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL (2006) Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth. Mol Cancer Ther 5:2503\u20132511","DOI":"10.1158\/1535-7163.MCT-06-0286"},{"issue":"4","key":"9_CR6","doi-asserted-by":"publisher","first-page":"e5119","DOI":"10.1371\/journal.pone.0005119","volume":"4","author":"M. Ver\u00f3nica Lopez","year":"2009","unstructured":"Lopez MV, Viale DL, Cafferata EG, Bravo AI, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL (2009) Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS One 4:e5119","journal-title":"PLoS ONE"},{"key":"9_CR7","doi-asserted-by":"crossref","unstructured":"Lopez MV, Rivera AA, Viale DL, Benedetti L, Cuneo N, Kimball KJ, Wang M, Douglas JT, Zhu ZB, Bravo AI et al (2012) A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice. Mol Ther 20(12):2222\u20132233","DOI":"10.1038\/mt.2012.147"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1038\/sj.onc.1206453","volume":"22","author":"C Tellez","year":"2003","unstructured":"Tellez C, Bar-Eli M (2003) Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 22:3130\u20133137","journal-title":"Oncogene"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1007\/s00018-003-3140-6","volume":"60","author":"T Arisato","year":"2003","unstructured":"Arisato T, Sarker KP, Kawahara K, Nakata M, Hashiguchi T, Osame M, Kitajima I, Maruyama I (2003) The agonist of the protease-activated receptor-1 (PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells. Cell Mol Life Sci 60:1716\u20131724","journal-title":"Cell Mol Life Sci"},{"key":"9_CR10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1096\/fj.02-0316com","volume":"17","author":"YJ Yin","year":"2003","unstructured":"Yin YJ, Salah Z, Maoz M, Even Ram SC, Ochayon S, Neufeld G, Katzav S, Bar-Shavit R (2003) Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation. FASEB J 17:163\u2013174","journal-title":"FASEB J"},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nm0898-909","volume":"4","author":"S Even-Ram","year":"1998","unstructured":"Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R (1998) Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 4:909\u2013914","journal-title":"Nat Med"},{"key":"9_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/sj.bjc.6690063","volume":"79","author":"KP Henrikson","year":"1999","unstructured":"Henrikson KP, Salazar SL, Fenton JW 2nd, Pentecost BT (1999) Role of thrombin receptor in breast cancer invasiveness. Br J Cancer 79:401\u2013406","journal-title":"Br J Cancer"},{"key":"9_CR13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/00006676-199803000-00013","volume":"16","author":"C Rudroff","year":"1998","unstructured":"Rudroff C, Schafberg H, Nowak G, Weinel R, Scheele J, Kaufmann R (1998) Characterization of functional thrombin receptors in human pancreatic tumor cells (MIA PACA-2). Pancreas 16:189\u2013194","journal-title":"Pancreas"},{"key":"9_CR14","first-page":"698","volume":"55","author":"MZ Wojtukiewicz","year":"1995","unstructured":"Wojtukiewicz MZ, Tang DG, Ben-Josef E, Renaud C, Walz DA, Honn KV (1995) Solid tumor cells express functional \u201ctethered ligand\u201d thrombin receptor. Cancer Res 55:698\u2013704","journal-title":"Cancer Res"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/pros.20326","volume":"66","author":"V Kaushal","year":"2006","unstructured":"Kaushal V, Kohli M, Dennis RA, Siegel ER, Chiles WW, Mukunyadzi P (2006) Thrombin receptor expression is upregulated in prostate cancer. Prostate 66:273\u2013282","journal-title":"Prostate"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/978-1-59745-528-2_21","volume":"402","author":"O Marshall","year":"2007","unstructured":"Marshall O (2007) Graphical design of primers with PerlPrimer. Methods Mol Biol 402:403\u2013414","journal-title":"Methods Mol Biol"},{"key":"9_CR17","doi-asserted-by":"crossref","unstructured":"Dmitriev I, Krasnykh V, Miller CR, Wang M, Kashentseva E, Mikheeva G, Belousova N, Curiel DT (1998) An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72:9706\u20139713","DOI":"10.1128\/JVI.72.12.9706-9713.1998"},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1089\/hum.1996.7.2-215","volume":"7","author":"FJ Fallaux","year":"1996","unstructured":"Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC, Van Der Eb AJ (1996) Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 7:215\u2013222","journal-title":"Hum Gene Ther"},{"key":"9_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1146\/annurev-micro-092412-155756","volume":"67","author":"KB Decker","year":"2013","unstructured":"Decker KB, Hinton DM (2013) Transcription regulation at the core: similarities among bacterial, archaeal, and eukaryotic RNA polymerases. Annu Rev Microbiol 67:113\u2013139","journal-title":"Annu Rev Microbiol"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"e27639","DOI":"10.4161\/trns.27369","volume":"5","author":"AG Arimbasseri","year":"2014","unstructured":"Arimbasseri AG, Rijal K, Maraia RJ (2014) Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation. Transcription 5:e27639","journal-title":"Transcription"},{"key":"9_CR21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ydbio.2009.08.009","volume":"339","author":"T Juven-Gershon","year":"2010","unstructured":"Juven-Gershon T, Kadonaga JT (2010) Regulation of gene expression via the core promoter and the basal transcriptional machinery. Dev Biol 339:225\u2013229","journal-title":"Dev Biol"},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gku1111","volume":"43","author":"R Dreos","year":"2015","unstructured":"Dreos R, Ambrosini G, Perier RC, Bucher P (2015) The eukaryotic promoter database: expansion of EPDnew and new promoter analysis tools. Nucleic Acids Res 43:D92\u2013D96","journal-title":"Nucleic Acids Res"},{"key":"9_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0097-8485(01)00099-7","volume":"26","author":"MG Reese","year":"2001","unstructured":"Reese MG (2001) Application of a time-delay neural network to promoter annotation in the Drosophila melanogaster genome. Comput Chem 26:51\u201356","journal-title":"Comput Chem"},{"key":"9_CR24","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1093\/nar\/gkg549","volume":"31","author":"AS Halees","year":"2003","unstructured":"Halees AS, Leyfer D, Weng Z (2003) PromoSer: a large-scale mammalian promoter and transcription start site identification service. Nucleic Acids Res 31:3554\u20133559","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"9_CR25","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/bioinformatics\/bti473","volume":"21","author":"K. Cartharius","year":"2005","unstructured":"Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, Frisch M, Bayerlein M, Werner T (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21:2933\u20132942","journal-title":"Bioinformatics"},{"key":"9_CR26","doi-asserted-by":"crossref","unstructured":"Chartier C, Degryse E, Gantzer M, Dieterle A, Pavirani A, Mehtali M (1996) Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol 70:4805\u20134810","DOI":"10.1128\/jvi.70.7.4805-4810.1996"},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"F Denizot","year":"1986","unstructured":"Denizot F, Lang R (1986) Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89:271\u2013277","journal-title":"J Immunol Methods"},{"key":"9_CR28","unstructured":"Jakubczak JL, Ryan P, Gorziglia M, Clarke L, Hawkins LK, Hay C, Huang Y, Kaloss M, Marinov A, Phipps S et al (2003) An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy. Cancer Res 63:1490\u20131499"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/hum.2004.15.995","volume":"15","author":"P Martin-Duque","year":"2004","unstructured":"Martin-Duque P, Jezzard S, Kaftansis L, Vassaux G (2004) Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes. Hum Gene Ther 15:995\u20131002","journal-title":"Hum Gene Ther"}],"container-title":["Methods in Molecular Biology","Mammalian Synthetic Promoters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7223-4_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:48:43Z","timestamp":1662166123000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-7223-4_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493972210","9781493972234"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7223-4_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"12 August 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}