{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:30:53Z","timestamp":1756463453196},"publisher-location":"New York, NY","reference-count":15,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493974580"},{"type":"electronic","value":"9781493974597"}],"license":[{"start":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T00:00:00Z","timestamp":1511568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-7459-7_13","type":"book-chapter","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T11:04:16Z","timestamp":1511521456000},"page":"173-181","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Studying TDP1 Function in DNA Repair"],"prefix":"10.1007","author":[{"given":"Shih-Chieh","family":"Chiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty","family":"Liversidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif F.","family":"El-Khamisy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,25]]},"reference":[{"key":"13_CR1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm831","volume":"3","author":"JC Wang","year":"2002","unstructured":"Wang JC (2002) Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 3:430\u2013440","journal-title":"Nat Rev Mol Cell Biol"},{"key":"13_CR2","doi-asserted-by":"crossref","first-page":"21074","DOI":"10.1074\/jbc.M803493200","volume":"283","author":"CP Lin","year":"2008","unstructured":"Lin CP, Ban Y, Lyu YL, Desai SD, Liu LF (2008) A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. J Biol Chem 283:21074\u201321083","journal-title":"J Biol Chem"},{"key":"13_CR3","doi-asserted-by":"crossref","first-page":"28084","DOI":"10.1074\/jbc.M109.030601","volume":"284","author":"CP Lin","year":"2009","unstructured":"Lin CP, Ban Y, Lyu YL, Liu LF (2009) Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks. J Biol Chem 284:28084\u201328092","journal-title":"J Biol Chem"},{"key":"13_CR4","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1038\/sj.emboj.7601869","volume":"26","author":"S Katyal","year":"2007","unstructured":"Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J 26:4720\u20134731","journal-title":"EMBO J"},{"key":"13_CR5","doi-asserted-by":"crossref","first-page":"12848","DOI":"10.1074\/jbc.M111.333963","volume":"287","author":"J Murai","year":"2012","unstructured":"Murai J, Huang SY, Das BB, Dexheimer TS, Takeda S, Pommier Y (2012) Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem 287:12848\u201312857","journal-title":"J Biol Chem"},{"key":"13_CR6","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1093\/nar\/gkt1260","volume":"42","author":"M Alagoz","year":"2014","unstructured":"Alagoz M, Wells OS, El-Khamisy SF (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucl Acids Res 42:3089\u20133103","journal-title":"Nucl Acids Res"},{"key":"13_CR7","doi-asserted-by":"crossref","first-page":"55618","DOI":"10.1074\/jbc.M405042200","volume":"279","author":"HU Barthelmes","year":"2004","unstructured":"Barthelmes HU, Habermeyer M, Christensen MO, Mielke C, Interthal H, Pouliot JJ, Boege F, Marko D (2004) TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II. J Biol Chem 279:55618\u201355625","journal-title":"J Biol Chem"},{"key":"13_CR8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00280-003-0717-6","volume":"53","author":"MC Nivens","year":"2004","unstructured":"Nivens MC, Felder T, Galloway AH, Pena MM, Pouliot JJ, Spencer HT (2004) Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase. Cancer Chemother Pharmacol 53:107\u2013115","journal-title":"Cancer Chemother Pharmacol"},{"key":"13_CR9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yexmp.2015.05.006","volume":"99","author":"AK Jakobsen","year":"2015","unstructured":"Jakobsen AK, Lauridsen KL, Samuel EB, Proszek J, Knudsen BR, Hager H, Stougaard M (2015) Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue. Exp Mol Pathol 99:56\u201364","journal-title":"Exp Mol Pathol"},{"key":"13_CR10","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1046\/j.1432-1033.2002.03059.x","volume":"269","author":"TJ Cheng","year":"2002","unstructured":"Cheng TJ, Rey PG, Poon T, Kan CC (2002) Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway. Eur J Biochem 269:3697\u20133704","journal-title":"Eur J Biochem"},{"key":"13_CR11","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1093\/nar\/gkm463","volume":"35","author":"S Antony","year":"2007","unstructured":"Antony S, Marchand C, Stephen AG, Thibaut L, Agama KK, Fisher RJ, Pommier Y (2007) Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic Acids Res 35:4474\u20134484","journal-title":"Nucleic Acids Res"},{"key":"13_CR12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1158\/1535-7163.MCT-08-0878","volume":"8","author":"C Marchand","year":"2009","unstructured":"Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A (2009) Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Mol Cancer Ther 8:240\u2013248","journal-title":"Mol Cancer Ther"},{"key":"13_CR13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bios.2013.04.019","volume":"48","author":"PW Jensen","year":"2013","unstructured":"Jensen PW, Falconi M, Kristoffersen EL, Simonsen AT, Cifuentes JB, Marcussen LB, Fr\u00f8hlich R, Vagner J, Harmsen C, Juul S, Ho YP, Withers MA, Lupski JR, Koch J, Desideri A, Knudsen BR, Stougaard M (2013) Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor. Biosens Bioelectron 48:230\u2013237","journal-title":"Biosens Bioelectron"},{"key":"13_CR14","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1073\/pnas.211429198","volume":"98","author":"H Interthal","year":"2001","unstructured":"Interthal H, Pouliot JJ, Champoux JJ (2001) The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily. Proc Natl Acad Sci U S A 98:12009\u201312014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"13_CR15","doi-asserted-by":"publisher","unstructured":"doi: \n10.1126\/sciadv.1602506","DOI":"10.1126\/sciadv.1602506"}],"container-title":["Methods in Molecular Biology","DNA Topoisomerases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7459-7_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T11:05:56Z","timestamp":1511521556000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-7459-7_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,25]]},"ISBN":["9781493974580","9781493974597"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7459-7_13","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2017,11,25]]}}}