{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:17:26Z","timestamp":1790705846583,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":99,"publisher":"Springer New York","isbn-type":[{"value":"9781493975709","type":"print"},{"value":"9781493975716","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T00:00:00Z","timestamp":1512777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-7571-6_2","type":"book-chapter","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T05:59:42Z","timestamp":1512712782000},"page":"19-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ocular Nerve Growth Factor (NGF) and NGF Eye Drop Application as Paradigms to Investigate NGF Neuroprotective and Reparative Actions"],"prefix":"10.1007","author":[{"given":"Paola","family":"Tirassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Iannitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,9]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.stem.2008.05.002","volume":"2","author":"D Lamba","year":"2008","unstructured":"Lamba D, Karl M, Reh T (2008) Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell 2:538\u2013549","journal-title":"Cell Stem Cell"},{"key":"2_CR2","first-page":"283","volume":"149","author":"A Lambiase","year":"2011","unstructured":"Lambiase A, Mantelli F, Sacchetti M, Rossi S, Aloe L, Bonini S (2011) Clinical applications of NGF in ocular diseases. Arch Ital Biol 149:283\u2013292","journal-title":"Arch Ital Biol"},{"key":"2_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","volume":"2","author":"A Patel","year":"2013","unstructured":"Patel A, Cholkar K, Agrahari V, Mitra AK (2013) Ocular drug delivery systems: an overview. World J Pharmacol 2:47\u201364","journal-title":"World J Pharmacol"},{"key":"2_CR4","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1006\/bbrc.2000.2473","volume":"270","author":"I Ahmad","year":"2000","unstructured":"Ahmad I, Tang L, Pham H (2000) Identification of neural progenitors in the adult mammalian eye. Biochem Biophys Res Commun 270:517\u2013521","journal-title":"Biochem Biophys Res Commun"},{"key":"2_CR5","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1126\/science.287.5460.2032","volume":"287","author":"V Tropepe","year":"2000","unstructured":"Tropepe V, Coles BL, Chiasson BJ et al (2000) Retinal stem cells in the adult mammalian eye. Science 287:2032\u20132036","journal-title":"Science"},{"key":"2_CR6","doi-asserted-by":"publisher","first-page":"9855","DOI":"10.1073\/pnas.0708405105","volume":"105","author":"DG Luo","year":"2008","unstructured":"Luo DG, Xue T, Yau KW (2008) How vision begins: an odyssey. Proc Natl Acad Sci U S A 105:9855\u20139862","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR7","doi-asserted-by":"crossref","unstructured":"Newman EA (2015) Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters. Philos Trans R Soc Lond Ser B Biol Sci 370. \n                  https:\/\/doi.org\/10.1098\/rstb.2014.0195","DOI":"10.1098\/rstb.2014.0195"},{"key":"2_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","volume":"43","author":"N Cuenca","year":"2014","unstructured":"Cuenca N, Fernandez-Sanchez L, Campello L et al (2014) Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Prog Retin Eye Res 43:17\u201375","journal-title":"Prog Retin Eye Res"},{"key":"2_CR9","first-page":"1","volume":"6","author":"JH Kaas","year":"2014","unstructured":"Kaas JH, Balaram P (2014) Current research on the organization and function of the visual system in primates. Eye Brain 6:1\u20134","journal-title":"Eye Brain"},{"key":"2_CR10","volume-title":"Sensation and perception","author":"S Yantis","year":"2014","unstructured":"Yantis S (2014) Sensation and perception. Palgrave Macmillan, Basingstoke"},{"key":"2_CR11","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414562107","volume":"6","author":"L Erskine","year":"2014","unstructured":"Erskine L, Herrera E (2014) Connecting the retina to the brain. ASN Neuro 6:1759091414562107","journal-title":"ASN Neuro"},{"key":"2_CR12","unstructured":"Bear MF, Connors BW, Paradiso MA (2007) Neuroscienze. Esplorando il cervello. Con CD-ROM: Elsevier srl"},{"key":"2_CR13","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1069609","volume":"295","author":"S Hattar","year":"2002","unstructured":"Hattar S, Liao HW, Takao M, Berson DM, Yau KW (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295:1065\u20131070","journal-title":"Science"},{"key":"2_CR14","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1126\/science.1067262","volume":"295","author":"DM Berson","year":"2002","unstructured":"Berson DM, Dunn FA, Takao M (2002) Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070\u20131073","journal-title":"Science"},{"key":"2_CR15","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/00001756-199503270-00025","volume":"6","author":"AS Elliott","year":"1995","unstructured":"Elliott AS, Weiss ML, Nunez AA (1995) Direct retinal communication with the peri-amygdaloid area. Neuroreport 6:806\u2013808","journal-title":"Neuroreport"},{"key":"2_CR16","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/89522","volume":"4","author":"G Aston-Jones","year":"2001","unstructured":"Aston-Jones G, Chen S, Zhu Y, Oshinsky ML (2001) A neural circuit for circadian regulation of arousal. Nat Neurosci 4:732\u2013738","journal-title":"Nat Neurosci"},{"key":"2_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ejpain.2005.12.005","volume":"11","author":"D Borsook","year":"2007","unstructured":"Borsook D, Becerra L, Carlezon WA Jr et al (2007) Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain 11:7\u201320","journal-title":"Eur J Pain"},{"key":"2_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainres.2006.10.063","volume":"1129","author":"EP Sleipness","year":"2007","unstructured":"Sleipness EP, Sorg BA, Jansen HT (2007) Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain Res 1129:34\u201342","journal-title":"Brain Res"},{"key":"2_CR19","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.cub.2008.04.012","volume":"18","author":"G Hampp","year":"2008","unstructured":"Hampp G, Ripperger JA, Houben T et al (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol 18:678\u2013683","journal-title":"Curr Biol"},{"key":"2_CR20","first-page":"437","volume":"13","author":"CS Bartheld von","year":"1998","unstructured":"von Bartheld CS (1998) Neurotrophins in the developing and regenerating visual system. Histol Histopathol 13:437\u2013459","journal-title":"Histol Histopathol"},{"key":"2_CR21","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/0014-4886(91)90097-V","volume":"111","author":"G Carmignoto","year":"1991","unstructured":"Carmignoto G, Comelli MC, Candeo P et al (1991) Expression of NGF receptor and NGF receptor mRNA in the developing and adult rat retina. Exp Neurol 111:302\u2013311","journal-title":"Exp Neurol"},{"key":"2_CR22","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1242\/dev.00224","volume":"130","author":"P Wahle","year":"2003","unstructured":"Wahle P, Di Cristo G, Schwerdtfeger G, Engelhardt M, Berardi N, Maffei L (2003) Differential effects of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Development 130:611\u2013622","journal-title":"Development"},{"key":"2_CR23","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1523\/JNEUROSCI.21-22-08915.2001","volume":"21","author":"R Butowt","year":"2001","unstructured":"Butowt R, von Bartheld CS (2001) Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: ultrastructural analysis in retinal ganglion cells. J Neurosci 21:8915\u20138930","journal-title":"J Neurosci"},{"key":"2_CR24","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1523\/JNEUROSCI.20-15-05671.2000","volume":"20","author":"Y Zhang","year":"2000","unstructured":"Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA (2000) Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci 20:5671\u20135678","journal-title":"J Neurosci"},{"key":"2_CR25","doi-asserted-by":"crossref","unstructured":"Mesentier-Louro LA, De Nicolo S, Rosso P et al (2017) Time-dependent nerve growth factor signaling changes in the rat retina during optic nerve crush-induced degeneration of retinal Ganglion cells. Int J Mol Sci 18. \n                  https:\/\/doi.org\/10.3390\/ijms18010098","DOI":"10.3390\/ijms18010098"},{"key":"2_CR26","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/S0960-9822(00)00713-2","volume":"10","author":"M Caleo","year":"2000","unstructured":"Caleo M, Menna E, Chierzi S, Cenni MC, Maffei L (2000) Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system. Curr Biol 10:1155\u20131161","journal-title":"Curr Biol"},{"key":"2_CR27","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.molmed.2010.07.005","volume":"16","author":"M Hatori","year":"2010","unstructured":"Hatori M, Panda S (2010) The emerging roles of melanopsin in behavioral adaptation to light. Trends Mol Med 16:435\u2013446","journal-title":"Trends Mol Med"},{"key":"2_CR28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.expneurol.2012.06.026","volume":"243","author":"LP Morin","year":"2013","unstructured":"Morin LP (2013) Neuroanatomy of the extended circadian rhythm system. Exp Neurol 243:4\u201320","journal-title":"Exp Neurol"},{"key":"2_CR29","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1523\/JNEUROSCI.5123-04.2005","volume":"25","author":"HK Teng","year":"2005","unstructured":"Teng HK, Teng KK, Lee R et al (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455\u20135463","journal-title":"J Neurosci"},{"key":"2_CR30","first-page":"2","volume":"e1247","author":"G Vandewalle","year":"2007","unstructured":"Vandewalle G, Schmidt C, Albouy G et al (2007) Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem. PLoS One e1247:2","journal-title":"PLoS One"},{"key":"2_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.tics.2009.07.004","volume":"13","author":"G Vandewalle","year":"2009","unstructured":"Vandewalle G, Maquet P, Dijk DJ (2009) Light as a modulator of cognitive brain function. Trends Cogn Sci 13:429\u2013438","journal-title":"Trends Cogn Sci"},{"key":"2_CR32","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","volume":"76","author":"MR Picciotto","year":"2012","unstructured":"Picciotto MR, Higley MJ, Mineur YS (2012) Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76:116\u2013129","journal-title":"Neuron"},{"key":"2_CR33","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nrn3743","volume":"15","author":"TA LeGates","year":"2014","unstructured":"LeGates TA, Fernandez DC, Hattar S (2014) Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci 15:443\u2013454","journal-title":"Nat Rev Neurosci"},{"key":"2_CR34","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.bbr.2010.11.039","volume":"221","author":"RA Hut","year":"2011","unstructured":"Hut RA, Van der Zee EA (2011) The cholinergic system, circadian rhythmicity, and time memory. Behav Brain Res 221:466\u2013480","journal-title":"Behav Brain Res"},{"key":"2_CR35","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1523\/JNEUROSCI.12-12-04651.1992","volume":"12","author":"L Maffei","year":"1992","unstructured":"Maffei L, Berardi N, Domenici L, Parisi V, Pizzorusso T (1992) Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats. J Neurosci 12:4651\u20134662","journal-title":"J Neurosci"},{"key":"2_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1098\/rspb.1993.0003","volume":"251","author":"N Berardi","year":"1993","unstructured":"Berardi N, Domenici L, Parisi V, Pizzorusso T, Cellerino A, Maffei L (1993) Monocular deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented by nerve growth factor (NGF). I. Visual cortex. Proc Biol Sci 251:17\u201323","journal-title":"Proc Biol Sci"},{"key":"2_CR37","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1046\/j.1460-9568.1999.00417.x","volume":"11","author":"T Pizzorusso","year":"1999","unstructured":"Pizzorusso T, Berardi N, Rossi FM et al (1999) TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation. Eur J Neurosci 11:204\u2013212","journal-title":"Eur J Neurosci"},{"key":"2_CR38","doi-asserted-by":"publisher","first-page":"11133","DOI":"10.1073\/pnas.91.23.11133","volume":"91","author":"DO Clary","year":"1994","unstructured":"Clary DO, Reichardt LF (1994) An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc Natl Acad Sci U S A 91:11133\u201311137","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0896-6273(00)80880-6","volume":"25","author":"E Pesavento","year":"2000","unstructured":"Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L (2000) Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron 25:165\u2013175","journal-title":"Neuron"},{"key":"2_CR40","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1523\/JNEUROSCI.22-03-00912.2002","volume":"22","author":"FM Rossi","year":"2002","unstructured":"Rossi FM, Sala R, Maffei L (2002) Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat: development and regulation by the cholinergic input. J Neurosci 22:912\u2013919","journal-title":"J Neurosci"},{"key":"2_CR41","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1111\/j.1460-9568.2006.05126.x","volume":"24","author":"S Patz","year":"2006","unstructured":"Patz S, Wahle P (2006) Developmental changes of neurotrophin mRNA expression in the layers of rat visual cortex. Eur J Neurosci 24:2453\u20132460","journal-title":"Eur J Neurosci"},{"key":"2_CR42","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1097\/00001756-199410270-00013","volume":"5","author":"L Domenici","year":"1994","unstructured":"Domenici L, Cellerino A, Berardi N, Cattaneo A, Maffei L (1994) Antibodies to nerve growth factor (NGF) prolong the sensitive period for monocular deprivation in the rat. Neuroreport 5:2041\u20132044","journal-title":"Neuroreport"},{"key":"2_CR43","doi-asserted-by":"publisher","first-page":"7337","DOI":"10.1073\/pnas.93.14.7337","volume":"93","author":"L Mrzljak","year":"1996","unstructured":"Mrzljak L, Levey AI, Rakic P (1996) Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex. Proc Natl Acad Sci U S A 93:7337\u20137340","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR44","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1152\/jn.1994.71.5.1935","volume":"71","author":"K Kawa","year":"1994","unstructured":"Kawa K (1994) Distribution and functional properties of 5-HT3 receptors in the rat hippocampal dentate gyrus: a patch-clamp study. J Neurophysiol 71:1935\u20131947","journal-title":"J Neurophysiol"},{"key":"2_CR45","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3389\/fncel.2014.00220","volume":"8","author":"J Biane","year":"2014","unstructured":"Biane J, Conner JM, Tuszynski MH (2014) Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Front Cell Neurosci 8:220","journal-title":"Front Cell Neurosci"},{"key":"2_CR46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00001756-199312000-00023","volume":"5","author":"JC Lauterborn","year":"1993","unstructured":"Lauterborn JC, Tran TM, Isackson PJ, Gall CM (1993) Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus. Neuroreport 5:273\u2013276","journal-title":"Neuroreport"},{"key":"2_CR47","first-page":"172","volume":"8","author":"JI Kang","year":"2014","unstructured":"Kang JI, Huppe-Gourgues F, Vaucher E (2014) Boosting visual cortex function and plasticity with acetylcholine to enhance visual perception. Front Syst Neurosci 8:172","journal-title":"Front Syst Neurosci"},{"key":"2_CR48","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1152\/jn.00489.2003","volume":"91","author":"N Prakash","year":"2004","unstructured":"Prakash N, Cohen-Cory S, Penschuck S, Frostig RD (2004) Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. J Neurophysiol 91:424\u2013437","journal-title":"J Neurophysiol"},{"key":"2_CR49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0166-4328(97)00142-3","volume":"93","author":"M Torasdotter","year":"1998","unstructured":"Torasdotter M, Metsis M, Henriksson BG, Winblad B, Mohammed AH (1998) Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus. Behav Brain Res 93:83\u201390","journal-title":"Behav Brain Res"},{"key":"2_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0304-3940(01)01648-2","volume":"302","author":"L Aloe","year":"2001","unstructured":"Aloe L, Fiore M, Santucci D et al (2001) Effect of hypergravity on the mouse basal expression of NGF and BDNF in the retina, visual cortex and geniculate nucleus: correlative aspects with NPY immunoreactivity. Neurosci Lett 302:29\u201332","journal-title":"Neurosci Lett"},{"key":"2_CR51","first-page":"51","volume":"5","author":"P Tirassa","year":"2011","unstructured":"Tirassa P, Quartini A, Iannitelli A (2011) Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the neurotrophic hypothesis. ChronoPhysiol Ther 5:51","journal-title":"ChronoPhysiol Ther"},{"key":"2_CR52","first-page":"284","volume":"47","author":"V Colafrancesco","year":"2011","unstructured":"Colafrancesco V, Coassin M, Rossi S, Aloe L (2011) Effect of eye NGF administration on two animal models of retinal ganglion cells degeneration. Ann Ist Super Sanita 47:284\u2013289","journal-title":"Ann Ist Super Sanita"},{"key":"2_CR53","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrn2215","volume":"8","author":"ED Herzog","year":"2007","unstructured":"Herzog ED (2007) Neurons and networks in daily rhythms. Nat Rev Neurosci 8:790\u2013802","journal-title":"Nat Rev Neurosci"},{"key":"2_CR54","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/15973","volume":"2","author":"T Ueyama","year":"1999","unstructured":"Ueyama T, Krout KE, Nguyen XV et al (1999) Suprachiasmatic nucleus: a central autonomic clock. Nat Neurosci 2:1051\u20131053","journal-title":"Nat Neurosci"},{"key":"2_CR55","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1006\/exnr.1998.6804","volume":"151","author":"FQ Liang","year":"1998","unstructured":"Liang FQ, Sohrabji F, Miranda R, Earnest B, Earnest D (1998) Expression of brain-derived neurotrophic factor and its cognate receptor, TrkB, in the rat suprachiasmatic nucleus. Exp Neurol 151:184\u2013193","journal-title":"Exp Neurol"},{"key":"2_CR56","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1460-9568.2005.04247.x","volume":"22","author":"GA Pizzio","year":"2005","unstructured":"Pizzio GA, Hainich EC, Plano SA, Ralph MR, Golombek DA (2005) Nerve growth factor-induced circadian phase shifts and MAP kinase activation in the hamster suprachiasmatic nuclei. Eur J Neurosci 22:665\u2013671","journal-title":"Eur J Neurosci"},{"key":"2_CR57","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/0006-8993(89)91259-6","volume":"476","author":"MV Sofroniew","year":"1989","unstructured":"Sofroniew MV, Isacson O, O\u2019Brien TS (1989) Nerve growth factor receptor immunoreactivity in the rat suprachiasmatic nucleus. Brain Res 476:358\u2013362","journal-title":"Brain Res"},{"key":"2_CR58","doi-asserted-by":"publisher","first-page":"10221","DOI":"10.1523\/JNEUROSCI.2757-12.2013","volume":"33","author":"B Baeza-Raja","year":"2013","unstructured":"Baeza-Raja B, Eckel-Mahan K, Zhang L et al (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci 33:10221\u201310234","journal-title":"J Neurosci"},{"key":"2_CR59","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/cne.903350212","volume":"335","author":"KG Bina","year":"1993","unstructured":"Bina KG, Rusak B, Semba K (1993) Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat. J Comp Neurol 335:295\u2013307","journal-title":"J Comp Neurol"},{"key":"2_CR60","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1097\/00001756-199608120-00020","volume":"7","author":"J Kiss","year":"1996","unstructured":"Kiss J, Halasz B (1996) Synaptic contacts between cholinergic afferents and suprachiasmatic neurones of the rat. Neuroreport 7:1961\u20131964","journal-title":"Neuroreport"},{"key":"2_CR61","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1006\/exnr.2002.7969","volume":"176","author":"C Beaule","year":"2002","unstructured":"Beaule C, Amir S (2002) Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats. Exp Neurol 176:377\u2013389","journal-title":"Exp Neurol"},{"key":"2_CR62","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1523\/JNEUROSCI.20-08-02978.2000","volume":"20","author":"FQ Liang","year":"2000","unstructured":"Liang FQ, Allen G, Earnest D (2000) Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light. J Neurosci 20:2978\u20132987","journal-title":"J Neurosci"},{"key":"2_CR63","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/j.1460-9568.2006.04972.x","volume":"24","author":"S Michel","year":"2006","unstructured":"Michel S, Clark JP, Ding JM, Colwell CS (2006) Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus. Eur J Neurosci 24:1109\u20131116","journal-title":"Eur J Neurosci"},{"key":"2_CR64","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1111\/j.1460-9568.2004.03281.x","volume":"19","author":"C Erhardt","year":"2004","unstructured":"Erhardt C, Galani R, Jeltsch H et al (2004) Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. Eur J Neurosci 19:1773\u20131788","journal-title":"Eur J Neurosci"},{"key":"2_CR65","first-page":"341","volume":"140","author":"L Maffei","year":"2002","unstructured":"Maffei L (2002) Plasticity in the visual system: role of neurotrophins and electrical activity. Arch Ital Biol 140:341\u2013346","journal-title":"Arch Ital Biol"},{"key":"2_CR66","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1046\/j.1460-9568.1998.00227.x","volume":"10","author":"R Sala","year":"1998","unstructured":"Sala R, Viegi A, Rossi FM et al (1998) Nerve growth factor and brain-derived neurotrophic factor increase neurotransmitter release in the rat visual cortex. Eur J Neurosci 10:2185\u20132191","journal-title":"Eur J Neurosci"},{"key":"2_CR67","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00441-002-0574-3","volume":"309","author":"J Hannibal","year":"2002","unstructured":"Hannibal J (2002) Neurotransmitters of the retino-hypothalamic tract. Cell Tissue Res 309:73\u201388","journal-title":"Cell Tissue Res"},{"key":"2_CR68","doi-asserted-by":"crossref","unstructured":"Carito V, Nicolo S, Fiore M, Maccarone M, Tirassa P (2015) Ocular nerve growth factor administration (oNGF) affects disease severity and inflammatory response in the brain of rats with experimental allergic encephalitis (EAE). Can J Physiol Pharmacol 1\u20138. \n                  https:\/\/doi.org\/10.1139\/cjpp-2015-0133","DOI":"10.1139\/cjpp-2015-0133"},{"key":"2_CR69","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1167\/iovs.05-0301","volume":"46","author":"A Lambiase","year":"2005","unstructured":"Lambiase A, Tirassa P, Micera A, Aloe L, Bonini S (2005) Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats. Invest Ophthalmol Vis Sci 46:3800\u20133806","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR70","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/cns.12661","volume":"23","author":"P Rosso","year":"2017","unstructured":"Rosso P, De Nicolo S, Carito V et al (2017) Ocular nerve growth factor administration modulates brain-derived neurotrophic factor signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci Ther 23:198\u2013208","journal-title":"CNS Neurosci Ther"},{"key":"2_CR71","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.addr.2005.09.004","volume":"57","author":"PM Hughes","year":"2005","unstructured":"Hughes PM, Olejnik O, Chang-Lin JE, Wilson CG (2005) Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev 57:2010\u20132032","journal-title":"Adv Drug Deliv Rev"},{"issue":"Suppl 1","key":"2_CR72","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/S0039-6257(02)00326-0","volume":"47","author":"DM Maurice","year":"2002","unstructured":"Maurice DM (2002) Drug delivery to the posterior segment from drops. Surv Ophthalmol 47(Suppl 1):S41\u2013S52","journal-title":"Surv Ophthalmol"},{"issue":"Suppl 1","key":"2_CR73","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1007\/BF02343055","volume":"234","author":"A Lambiase","year":"1996","unstructured":"Lambiase A, Aloe L (1996) Nerve growth factor delays retinal degeneration in C3H mice. Graefes Arch Clin Exp Ophthalmol 234(Suppl 1):S96\u2013100","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2_CR74","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/ejn.12854","volume":"41","author":"P Tirassa","year":"2015","unstructured":"Tirassa P, Maccarone M, Carito V, De Nicolo S, Fiore M (2015) Ocular nerve growth factor administration counteracts the impairment of neural precursor cell viability and differentiation in the brain subventricular area of rats with streptozotocin-induced diabetes. Eur J Neurosci 41:1207\u20131218","journal-title":"Eur J Neurosci"},{"key":"2_CR75","first-page":"2334","volume":"43","author":"A Lambiase","year":"2002","unstructured":"Lambiase A, Bonini S, Manni L et al (2002) Intraocular production and release of nerve growth factor after iridectomy. Invest Ophthalmol Vis Sci 43:2334\u20132340","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR76","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12967-015-0750-3","volume":"14","author":"B Falsini","year":"2016","unstructured":"Falsini B, Iarossi G, Chiaretti A et al (2016) NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study. J Transl Med 14:8","journal-title":"J Transl Med"},{"key":"2_CR77","first-page":"439","volume":"45","author":"A Lambiase","year":"2009","unstructured":"Lambiase A, Coassin M, Tirassa P, Mantelli F, Aloe L (2009) Nerve growth factor eye drops improve visual acuity and electrofunctional activity in age-related macular degeneration: a case report. Ann Ist Super Sanita 45:439\u2013442","journal-title":"Ann Ist Super Sanita"},{"key":"2_CR78","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1089\/jop.2010.0139","volume":"27","author":"A Calza","year":"2011","unstructured":"Calza A, Florenzano F, Pellegrini D, Tirassa P (2011) Time-dependent activation of c-fos in limbic brain areas by ocular administration of nerve growth factor in adult rats. J Ocul Pharmacol Ther 27:209\u2013218","journal-title":"J Ocul Pharmacol Ther"},{"key":"2_CR79","first-page":"1272","volume":"39","author":"A Lambiase","year":"1998","unstructured":"Lambiase A, Bonini S, Micera A, Rama P, Bonini S, Aloe L (1998) Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases. Invest Ophthalmol Vis Sci 39:1272\u20131275","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR80","doi-asserted-by":"publisher","first-page":"8280","DOI":"10.1167\/iovs.12-10593","volume":"53","author":"A Lambiase","year":"2012","unstructured":"Lambiase A, Aloe L, Mantelli F et al (2012) Capsaicin-induced corneal sensory denervation and healing impairment are reversed by NGF treatment. Invest Ophthalmol Vis Sci 53:8280\u20138287","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR81","first-page":"571","volume":"8","author":"M Sacchetti","year":"2014","unstructured":"Sacchetti M, Lambiase A (2014) Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol 8:571\u2013579","journal-title":"Clin Ophthalmol"},{"key":"2_CR82","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.phrs.2008.01.010","volume":"57","author":"L Aloe","year":"2008","unstructured":"Aloe L, Tirassa P, Lambiase A (2008) The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers. Pharmacol Res 57:253\u2013258","journal-title":"Pharmacol Res"},{"key":"2_CR83","doi-asserted-by":"crossref","unstructured":"Soto I, Howell GR (2014) The complex role of neuroinflammation in glaucoma. Cold Spring Harb Perspect Med 4. \n                  https:\/\/doi.org\/10.1101\/cshperspect.a017269","DOI":"10.1101\/cshperspect.a017269"},{"key":"2_CR84","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1358\/dnp.2010.23.6.1472299","volume":"23","author":"A Lambiase","year":"2010","unstructured":"Lambiase A, Mantelli F, Bonini S (2010) Nerve growth factor eye drops to treat glaucoma. Drug News Perspect 23:361\u2013367","journal-title":"Drug News Perspect"},{"key":"2_CR85","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"M Almasieh","year":"2012","unstructured":"Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152\u2013181","journal-title":"Prog Retin Eye Res"},{"key":"2_CR86","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-2202-10-52","volume":"10","author":"S Sivilia","year":"2009","unstructured":"Sivilia S, Giuliani A, Fernandez M et al (2009) Intravitreal NGF administration counteracts retina degeneration after permanent carotid artery occlusion in rat. BMC Neurosci 10:52","journal-title":"BMC Neurosci"},{"key":"2_CR87","doi-asserted-by":"publisher","first-page":"13469","DOI":"10.1073\/pnas.0906678106","volume":"106","author":"A Lambiase","year":"2009","unstructured":"Lambiase A, Aloe L, Centofanti M et al (2009) Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: implications for glaucoma. Proc Natl Acad Sci U S A 106:13469\u201313474","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR88","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/brain\/awv366","volume":"139","author":"B Falsini","year":"2016","unstructured":"Falsini B, Chiaretti A, Rizzo D et al (2016) Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial. Brain 139:404\u2013414","journal-title":"Brain"},{"key":"2_CR89","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1177\/1545968310397201","volume":"25","author":"B Falsini","year":"2011","unstructured":"Falsini B, Chiaretti A, Barone G et al (2011) Topical nerve growth factor as a visual rescue strategy in pediatric optic gliomas: a pilot study including electrophysiology. Neurorehabil Neural Repair 25:512\u2013520","journal-title":"Neurorehabil Neural Repair"},{"key":"2_CR90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124810","volume":"10","author":"ML Rocco","year":"2015","unstructured":"Rocco ML, Balzamino BO, Petrocchi Passeri P, Micera A, Aloe L (2015) Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa. PLoS One 10:e0124810","journal-title":"PLoS One"},{"key":"2_CR91","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.visres.2008.09.024","volume":"49","author":"V Sposato","year":"2009","unstructured":"Sposato V, Parisi V, Manni L et al (2009) Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application. Vis Res 49:54\u201363","journal-title":"Vis Res"},{"key":"2_CR92","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/cns.12085","volume":"19","author":"P Tirassa","year":"2013","unstructured":"Tirassa P, Maccarone M, Florenzano F, Cartolano S, De Nicolo S (2013) Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy. CNS Neurosci Ther 19:307\u2013318","journal-title":"CNS Neurosci Ther"},{"key":"2_CR93","first-page":"7","volume":"e32796","author":"H Waiczies","year":"2012","unstructured":"Waiczies H, Millward JM, Lepore S et al (2012) Identification of cellular infiltrates during early stages of brain inflammation with magnetic resonance microscopy. PLoS One e32796:7","journal-title":"PLoS One"},{"key":"2_CR94","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/1521-4141(200101)31:1<11::AID-IMMU11>3.0.CO;2-G","volume":"31","author":"A Flugel","year":"2001","unstructured":"Flugel A, Matsumuro K, Neumann H et al (2001) Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: inhibition of monocyte transendothelial migration. Eur J Immunol 31:11\u201322","journal-title":"Eur J Immunol"},{"key":"2_CR95","doi-asserted-by":"publisher","first-page":"R38","DOI":"10.1016\/S0960-9822(06)00016-9","volume":"7","author":"AM Davies","year":"1997","unstructured":"Davies AM (1997) Neurotrophins: the yin and yang of nerve growth factor. Curr Biol 7:R38\u2013R40","journal-title":"Curr Biol"},{"key":"2_CR96","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.visres.2004.12.020","volume":"45","author":"L Lenzi","year":"2005","unstructured":"Lenzi L, Coassin M, Lambiase A, Bonini S, Amendola T, Aloe L (2005) Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. Vis Res 45:1491\u20131500","journal-title":"Vis Res"},{"key":"2_CR97","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrn3723","volume":"15","author":"D Goldman","year":"2014","unstructured":"Goldman D (2014) Muller glial cell reprogramming and retina regeneration. Nat Rev Neurosci 15:431\u2013442","journal-title":"Nat Rev Neurosci"},{"key":"2_CR98","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","volume":"22","author":"A Alvarez-Buylla","year":"2002","unstructured":"Alvarez-Buylla A, Garcia-Verdugo JM (2002) Neurogenesis in adult subventricular zone. J Neurosci 22:629\u2013634","journal-title":"J Neurosci"},{"key":"2_CR99","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5301\/ejo.5000359","volume":"24","author":"F Mantelli","year":"2013","unstructured":"Mantelli F, Lambiase A, Colafrancesco V, Rocco ML, Macchi I, Aloe L (2013) NGF and VEGF effects on retinal ganglion cell fate: new evidence from an animal model of diabetes. Eur J Ophthalmol 24:247\u2013253","journal-title":"Eur J Ophthalmol"}],"container-title":["Methods in Molecular Biology","Neurotrophic Factors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7571-6_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T04:11:03Z","timestamp":1558066263000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-7571-6_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,9]]},"ISBN":["9781493975709","9781493975716"],"references-count":99,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7571-6_2","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,9]]},"assertion":[{"value":"9 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}