{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:00:47Z","timestamp":1791651647219,"version":"4.3.4"},"publisher-location":"New York, NY","reference-count":19,"publisher":"Springer New York","isbn-type":[{"value":"9781493979011","type":"print"},{"value":"9781493979028","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-7902-8_11","type":"book-chapter","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T09:26:51Z","timestamp":1528709211000},"page":"111-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro"],"prefix":"10.1007","author":[{"given":"Jin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Lesmana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winifred W. Y.","family":"Yau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"11_CR1","doi-asserted-by":"publisher","first-page":"C11","DOI":"10.1083\/jcb.35.2.C11","volume":"35","author":"RL Deter","year":"1967","unstructured":"Deter RL, Baudhuin P, De Duve C (1967) Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol 35:C11\u2013C16","journal-title":"J Cell Biol"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ncb2788","volume":"15","author":"P Boya","year":"2013","unstructured":"Boya P, Reggiori F, Codogno P (2013) Emerging regulation and functions of autophagy. Nat Cell Biol 15:713\u2013720","journal-title":"Nat Cell Biol"},{"key":"11_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/cr.2013.168","volume":"24","author":"Y Feng","year":"2014","unstructured":"Feng Y, He D, Yao Z, Klionsky DJ (2014) The machinery of macroautophagy. Cell Res 24:24\u201341","journal-title":"Cell Res"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0014-5793(93)80398-E","volume":"333","author":"M Tsukada","year":"1993","unstructured":"Tsukada M, Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333:169\u2013174","journal-title":"FEBS Lett"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"er20161103","DOI":"10.1210\/er.2016-1103","volume":"2016","author":"RA Sinha","year":"2016","unstructured":"Sinha RA, Singh BK, Yen PM (2016) Reciprocal crosstalk between autophagic and endocrine signaling in metabolic homeostasis. Endocr Rev 2016:er20161103","journal-title":"Endocr Rev"},{"key":"11_CR6","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1172\/JCI60047","volume":"122","author":"GA Brent","year":"2012","unstructured":"Brent GA (2012) Mechanisms of thyroid hormone action. J Clin Invest 122:3035\u20133043","journal-title":"J Clin Invest"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4161\/auto.26126","volume":"10","author":"YH Tseng","year":"2014","unstructured":"Tseng YH, Ke PY, Liao CJ, Wu SM, Chi HC, Tsai CY, Chen CY, Lin YH, Lin KH (2014) Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism. Autophagy 10:20\u201331","journal-title":"Autophagy"},{"key":"11_CR8","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1172\/JCI60580","volume":"122","author":"RA Sinha","year":"2012","unstructured":"Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM (2012) Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest 122:2428\u20132438","journal-title":"J Clin Invest"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1080\/15548627.2015.1061849","volume":"11","author":"RA Sinha","year":"2015","unstructured":"Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM (2015) Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 11:1341\u20131357","journal-title":"Autophagy"},{"key":"11_CR10","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1080\/15548627.2016.1230583","volume":"12","author":"HC Chi","year":"2016","unstructured":"Chi HC, Chen SL, Tsai CY, Chuang WY, Huang YH, Tsai MM, Wu SM, Sun CP, Yeh CT, Lin KH (2016) Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy 12:2271\u20132285","journal-title":"Autophagy"},{"key":"11_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1210\/en.2015-1632","volume":"157","author":"R Lesmana","year":"2016","unstructured":"Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM (2016) Thyroid hormone stimulation of autophagy is essential for mitochondrial biogenesis and activity in skeletal muscle. Endocrinology 157:23\u201338","journal-title":"Endocrinology"},{"key":"11_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","volume":"12","author":"DJ Klionsky","year":"2016","unstructured":"Klionsky DJ et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1\u2013222","journal-title":"Autophagy"},{"key":"11_CR13","doi-asserted-by":"publisher","first-page":"51841","DOI":"10.1074\/jbc.M308762200","volume":"278","author":"J Hemelaar","year":"2003","unstructured":"Hemelaar J, Lelyveld VS, Kessler BM, Ploegh HL (2003) A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem 278:51841\u201351850","journal-title":"J Biol Chem"},{"key":"11_CR14","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1083\/jcb.200507002","volume":"171","author":"G Bjorkoy","year":"2005","unstructured":"Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005) p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171:603\u2013614","journal-title":"J Cell Biol"},{"key":"11_CR15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4161\/auto.4600","volume":"3","author":"N Mizushima","year":"2007","unstructured":"Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542\u2013545","journal-title":"Autophagy"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4161\/auto.4451","volume":"3","author":"S Kimura","year":"2007","unstructured":"Kimura S, Noda T, Yoshimori T (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3:452\u2013460","journal-title":"Autophagy"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.molcel.2016.09.037","volume":"64","author":"T Kaizuka","year":"2016","unstructured":"Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N (2016) An autophagic flux probe that releases an internal control. Mol Cell 64:835\u2013849","journal-title":"Mol Cell"},{"key":"11_CR18","first-page":"439","volume":"61","author":"S Paglin","year":"2001","unstructured":"Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J (2001) A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61:439\u2013444","journal-title":"Cancer Res"},{"key":"11_CR19","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.114.20.3619","volume":"114","author":"DB Munafo","year":"2001","unstructured":"Munafo DB, Colombo MI (2001) A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci 114:3619\u20133629","journal-title":"J Cell Sci"}],"container-title":["Methods in Molecular Biology","Thyroid Hormone Nuclear Receptor"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7902-8_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T12:06:55Z","timestamp":1661429215000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-7902-8_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9781493979011","9781493979028"],"references-count":19,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7902-8_11","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}