{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:00:00Z","timestamp":1775743200822,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":36,"publisher":"Springer New York","isbn-type":[{"value":"9781493985999","type":"print"},{"value":"9781493986002","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-8600-2_6","type":"book-chapter","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T06:56:39Z","timestamp":1530255399000},"page":"47-66","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Three-Dimensional Cell Culture Model Utilization in Renal Carcinoma Cancer Stem Cell Research"],"prefix":"10.1007","author":[{"given":"Kamila","family":"Maliszewska-Olejniczak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia K.","family":"Brodaczewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia F.","family":"Bielecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Czarnecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"key":"6_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/annonc\/mdl498","volume":"18","author":"J Ferlay","year":"2007","unstructured":"Ferlay J, Autier P, Boniol M et al (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581\u2013592","journal-title":"Ann Oncol"},{"key":"6_CR2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/286985","volume":"2011","author":"B Bussolati","year":"2011","unstructured":"Bussolati B, Brossa A, Camussi G (2011) Resident stem cells and renal carcinoma. Int J Nephrol 2011:286985","journal-title":"Int J Nephrol"},{"key":"6_CR3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1056\/NEJMoa060655","volume":"356","author":"B Escudier","year":"2007","unstructured":"Escudier B, Eisen T, Stadler WM et al (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125\u2013134","journal-title":"N Engl J Med"},{"key":"6_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJMoa065044","volume":"356","author":"RJ Motzer","year":"2007","unstructured":"Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115\u2013124","journal-title":"N Engl J Med"},{"key":"6_CR5","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1111\/j.1464-410X.2010.09829.x","volume":"107","author":"J Bellmunt","year":"2011","unstructured":"Bellmunt J, Eisen T, Szczylik C et al (2011) A new patient-focused approach to the treatment of metastatic renal cell carcinoma: establishing customized treatment options. BJU Int 107:1190\u20131199","journal-title":"BJU Int"},{"key":"6_CR6","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1096\/fj.08-102590","volume":"22","author":"B Bussolati","year":"2008","unstructured":"Bussolati B, Bruno S, Grange C et al (2008) Identification of a tumor-initiating stem cell population in human renal carcinomas. FASEB J 22:3696\u20133705","journal-title":"FASEB J"},{"key":"6_CR7","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1089\/scd.2008.0302","volume":"18","author":"JE Oates","year":"2009","unstructured":"Oates JE, Grey BR, Addla SK et al (2009) Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers. Stem Cells Dev 18:1515\u20131522","journal-title":"Stem Cells Dev"},{"key":"6_CR8","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.2353\/ajpath.2006.060498","volume":"169","author":"S Bruno","year":"2006","unstructured":"Bruno S, Bussolati B, Grange C et al (2006) CD133+ renal progenitor cells contribute to tumor angiogenesis. Am J Pathol 169:2223\u20132235","journal-title":"Am J Pathol"},{"key":"6_CR9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/1476-4598-9-180","volume":"9","author":"BG Debeb","year":"2010","unstructured":"Debeb BG, Zhang X, Krishnamurthy S et al (2010) Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer 9:180","journal-title":"Mol Cancer"},{"key":"6_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075463","volume":"8","author":"K Ueda","year":"2013","unstructured":"Ueda K, Ogasawara S, Akiba J et\u00a0al (2013) Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line. PLoS One 8:e75463","journal-title":"PLoS One"},{"key":"6_CR11","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1002\/stem.1407","volume":"31","author":"M Gassenmaier","year":"2013","unstructured":"Gassenmaier M, Chen D, Buchner A et al (2013) CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. Stem Cells 31:1467\u20131476","journal-title":"Stem Cells"},{"key":"6_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/emmm.201201516","volume":"5","author":"N Pode-Shakked","year":"2013","unstructured":"Pode-Shakked N, Shukrun R, Mark-Danieli M et al (2013) The isolation and characterization of renal cancer initiating cells from human Wilms\u2019 tumour xenografts unveils new therapeutic targets. EMBO Mol Med 5:18\u201337","journal-title":"EMBO Mol Med"},{"key":"6_CR13","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1158\/0008-5472.CAN-11-3062","volume":"72","author":"S Nishizawa","year":"2012","unstructured":"Nishizawa S, Hirohashi Y, Torigoe T et al (2012) HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. Cancer Res 72:2844\u20132854","journal-title":"Cancer Res"},{"key":"6_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068293","volume":"8","author":"B Huang","year":"2013","unstructured":"Huang B, Huang YJ, Yao ZJ et al (2013) Cancer stem cell-like side population cells in clear cell renal cell carcinoma cell line 769P. PLoS One 8:e68293","journal-title":"PLoS One"},{"key":"6_CR15","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.3892\/ol.2013.1270","volume":"5","author":"J Lu","year":"2013","unstructured":"Lu J, Cui Y, Zhu J et\u00a0al (2013) Biological characteristics of Rh123(high) stem-like cells in a side population of 786-O renal carcinoma cells. Oncol Lett 5:1903\u20131908","journal-title":"Oncol Lett"},{"key":"6_CR16","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.biomaterials.2011.10.056","volume":"33","author":"L Chen","year":"2012","unstructured":"Chen L, Xiao Z, Meng Y et al (2012) The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials 33:1437\u20131444","journal-title":"Biomaterials"},{"key":"6_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165718","volume":"11","author":"MI Khan","year":"2016","unstructured":"Khan MI, Czarnecka AM, Lewicki S et al (2016) Comparative gene expression profiling of primary and metastatic renal cell carcinoma stem cell-like cancer cells. PLoS One 11:e0165718","journal-title":"PLoS One"},{"key":"6_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12885-016-2985-7","volume":"17","author":"D Matak","year":"2017","unstructured":"Matak D, Brodaczewska KK, Szczylik C et al (2017) Functional significance of CD105-positive cells in papillary renal cell carcinoma. BMC Cancer 17:21","journal-title":"BMC Cancer"},{"key":"6_CR19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10616-016-0063-2","volume":"69","author":"D Matak","year":"2017","unstructured":"Matak D, Brodaczewska KK, Lipiec M et al (2017) Colony, hanging drop, and methylcellulose three dimensional hypoxic growth optimization of renal cell carcinoma cell lines. Cytotechnology 69:565\u2013578","journal-title":"Cytotechnology"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth1015","volume":"4","author":"GY Lee","year":"2007","unstructured":"Lee GY, Kenny PA, Lee EH, Bissell MJ (2007) Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 4:359\u2013365","journal-title":"Nat Methods"},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1290\/1543-706X(2003)039<0440:EOHSCL>2.0.CO;2","volume":"39","author":"J Kano","year":"2003","unstructured":"Kano J, Ishiyama T, Nakamura N et al (2003) Establishment of hepatic stem-like cell lines from normal adult porcine liver in a poly-D-lysine-coated dish with NAIR-1 medium. Vitro Cell Dev Biol Anim 39:440\u2013448","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"6_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059591","volume":"8","author":"Q Lepiller","year":"2013","unstructured":"Lepiller Q, Abbas W, Kumar A et al (2013) HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes. PLoS One 8:e59591","journal-title":"PLoS One"},{"key":"6_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134093","volume":"10","author":"S Rajasingh","year":"2015","unstructured":"Rajasingh S, Thangavel J, Czirok A et al (2015) Generation of functional cardiomyocytes from efficiently generated human iPSCs and a novel method of measuring contractility. PLoS One 10:e0134093","journal-title":"PLoS One"},{"key":"6_CR24","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/BF02797460","volume":"12","author":"RD Williams","year":"1976","unstructured":"Williams RD, Elliott AY, Stein N, Fraley EE (1976) In vitro cultivation of human renal cell cancer. I. Establishment of cells in culture. In Vitro 12:623\u2013627","journal-title":"In Vitro"},{"key":"6_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000107804","volume":"107","author":"N Glube","year":"2007","unstructured":"Glube N, Giessl A, Wolfrum U, Langguth P (2007) Caki-1 cells represent an in vitro model system for studying the human proximal tubule epithelium. Nephron Exp Nephrol 107:47\u201356","journal-title":"Nephron Exp Nephrol"},{"key":"6_CR26","first-page":"2968","volume":"50","author":"J Kochevar","year":"1990","unstructured":"Kochevar J (1990) Blockage of autonomous growth of ACHN cells by anti-renal cell carcinoma monoclonal antibody 5F4. Cancer Res 50:2968\u20132972","journal-title":"Cancer Res"},{"key":"6_CR27","first-page":"19","volume":"3","author":"C Windm\u00fcller","year":"2015","unstructured":"Windm\u00fcller C, Bronger H, Davoodi M et al (2015) The role of CXCR3\/ligand axis in cancer. Int Trends Immun 3:19\u201325","journal-title":"Int Trends Immun"},{"key":"6_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12943-016-0565-8","volume":"15","author":"KK Brodaczewska","year":"2016","unstructured":"Brodaczewska KK, Szczylik C, Fiedorowicz M et al (2016) Choosing the right cell line for renal cell cancer research. Mol Cancer 15:83","journal-title":"Mol Cancer"},{"key":"6_CR29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bbrc.2007.02.156","volume":"356","author":"R Roskoski","year":"2007","unstructured":"Roskoski R (2007) Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun 356:323\u2013328","journal-title":"Biochem Biophys Res Commun"},{"key":"6_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nbt1358","volume":"26","author":"MW Karaman","year":"2008","unstructured":"Karaman MW, Herrgard S, Treiber DK et al (2008) A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26:127\u2013132","journal-title":"Nat Biotechnol"},{"key":"6_CR31","doi-asserted-by":"publisher","first-page":"15105","DOI":"10.1074\/jbc.M117.783175","volume":"292","author":"C Zhang","year":"2017","unstructured":"Zhang C, Liu Z, Bunker E et al (2017) Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-parkin pathway and modulate cellular drug response. J Biol Chem 292:15105\u201315120","journal-title":"J Biol Chem"},{"key":"6_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-3-642-01222-8_3","volume":"184","author":"RJ Kelly","year":"2010","unstructured":"Kelly RJ, Rixe O (2010) Axitinib (AG-013736). Recent Results Cancer Res 184:33\u201344","journal-title":"Recent Results Cancer Res"},{"key":"6_CR33","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.2217\/fon.11.107","volume":"7","author":"TH Ho","year":"2011","unstructured":"Ho TH, Jonasch E (2011) Axitinib in the treatment of metastatic renal cell carcinoma. Fut Oncol 7:1247\u20131253","journal-title":"Fut Oncol"},{"key":"6_CR34","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1093\/annonc\/mdw287","volume":"27","author":"AL Ho","year":"2016","unstructured":"Ho AL, Dunn L, Sherman EJ et al (2016) A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma. Ann Oncol 27:1902\u20131908","journal-title":"Ann Oncol"},{"key":"6_CR35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1586\/era.09.27","volume":"9","author":"S Oudard","year":"2009","unstructured":"Oudard S, Medioni J, Aylllon J et\u00a0al (2009) Everolimus (RAD001): an mTOR inhibitor for the treatment of metastatic renal cell carcinoma. Expert Rev Anticancer Ther 9:705\u2013717","journal-title":"Expert Rev Anticancer Ther"},{"key":"6_CR36","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2217\/fon.14.303","volume":"11","author":"AM Czarnecka","year":"2015","unstructured":"Czarnecka AM, Kornakiewicz A, Lian F, Szczylik C (2015) Future perspectives for mTOR inhibitors in renal cell cancer treatment. Fut Oncol 11:801\u2013817","journal-title":"Fut Oncol"}],"container-title":["Methods in Molecular Biology","Epithelial Cell Culture"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-8600-2_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T06:56:47Z","timestamp":1530255407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-8600-2_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9781493985999","9781493986002"],"references-count":36,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-8600-2_6","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}