{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:00:47Z","timestamp":1793372447315,"version":"4.5.0"},"publisher-location":"New York, NY","reference-count":275,"publisher":"Springer New York","isbn-type":[{"value":"9781493986712","type":"print"},{"value":"9781493986729","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-8672-9_3","type":"book-chapter","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T09:24:21Z","timestamp":1534238661000},"page":"69-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Phospholipases: An Overview"],"prefix":"10.1007","author":[{"given":"Ahmed","family":"Aloulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Rahier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Arhab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Noiriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkarim","family":"Abousalham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"issue":"45","key":"3_CR1","doi-asserted-by":"publisher","first-page":"6032","DOI":"10.1002\/anie.200460416","volume":"43","author":"UT Bornscheuer","year":"2004","unstructured":"Bornscheuer UT, Kazlauskas RJ (2004) Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways. Angew Chem Int Ed Engl 43(45):6032\u20136040. https:\/\/doi.org\/10.1002\/anie.200460416","journal-title":"Angew Chem Int Ed Engl"},{"issue":"2","key":"3_CR2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s00253-006-0775-x","volume":"74","author":"L Maria De","year":"2007","unstructured":"De Maria L, Vind J, Oxenboll KM, Svendsen A, Patkar S (2007) Phospholipases and their industrial applications. Appl Microbiol Biotechnol 74(2):290\u2013300. https:\/\/doi.org\/10.1007\/s00253-006-0775-x","journal-title":"Appl Microbiol Biotechnol"},{"issue":"2","key":"3_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cbpa.2005.02.008","volume":"9","author":"RJ Kazlauskas","year":"2005","unstructured":"Kazlauskas RJ (2005) Enhancing catalytic promiscuity for biocatalysis. Curr Opin Chem Biol 9(2):195\u2013201. https:\/\/doi.org\/10.1016\/j.cbpa.2005.02.008","journal-title":"Curr Opin Chem Biol"},{"key":"3_CR4","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/S0021-9258(18)64604-6","volume":"235","author":"WE Lands","year":"1960","unstructured":"Lands WE (1960) Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J Biol Chem 235:2233\u20132237","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR5","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3390\/ijms12010588","volume":"12","author":"GS Richmond","year":"2011","unstructured":"Richmond GS, Smith TK (2011) Phospholipases A(1). Int J Mol Sci 12(1):588\u2013612. https:\/\/doi.org\/10.3390\/ijms12010588","journal-title":"Int J Mol Sci"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev.biochem.73.011303.073731","volume":"73","author":"I Ishii","year":"2004","unstructured":"Ishii I, Fukushima N, Ye X, Chun J (2004) Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 73:321\u2013354. https:\/\/doi.org\/10.1146\/annurev.biochem.73.011303.073731","journal-title":"Annu Rev Biochem"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/1471-2180-9-261","volume":"9","author":"K Shimuta","year":"2009","unstructured":"Shimuta K, Ohnishi M, Iyoda S, Gotoh N, Koizumi N, Watanabe H (2009) The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA. BMC Microbiol 9:261. https:\/\/doi.org\/10.1186\/1471-2180-9-261","journal-title":"BMC Microbiol"},{"issue":"8","key":"3_CR8","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1128\/IAI.66.8.3941-3951.1998","volume":"66","author":"DH Schmiel","year":"1998","unstructured":"Schmiel DH, Wagar E, Karamanou L, Weeks D, Miller VL (1998) Phospholipase A of Yersinia enterocolitica contributes to pathogenesis in a mouse model. Infect Immun 66(8):3941\u20133951","journal-title":"Infect Immun"},{"issue":"2","key":"3_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.biochi.2006.09.021","volume":"89","author":"J Aoki","year":"2007","unstructured":"Aoki J, Inoue A, Makide K, Saiki N, Arai H (2007) Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. Biochimie 89(2):197\u2013204. https:\/\/doi.org\/10.1016\/j.biochi.2006.09.021","journal-title":"Biochimie"},{"issue":"4","key":"3_CR10","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1074\/jbc.272.4.2192","volume":"272","author":"T Sato","year":"1997","unstructured":"Sato T, Aoki J, Nagai Y, Dohmae N, Takio K, Doi T, Arai H, Inoue K (1997) Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. J Biol Chem 272(4):2192\u20132198","journal-title":"J Biol Chem"},{"issue":"49","key":"3_CR11","doi-asserted-by":"publisher","first-page":"49438","DOI":"10.1074\/jbc.M213018200","volume":"278","author":"T Hiramatsu","year":"2003","unstructured":"Hiramatsu T, Sonoda H, Takanezawa Y, Morikawa R, Ishida M, Kasahara K, Sanai Y, Taguchi R, Aoki J, Arai H (2003) Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. J Biol Chem 278(49):49438\u201349447. https:\/\/doi.org\/10.1074\/jbc.M213018200","journal-title":"J Biol Chem"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"8745","DOI":"10.1038\/ncomms9745","volume":"6","author":"S Agarwal","year":"2015","unstructured":"Agarwal S, Kim H, Chan RB, Agarwal S, Williamson R, Cho W, Di Paolo G, Satchell KJF (2015) Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity. Nat Commun 6:8745. https:\/\/doi.org\/10.1038\/ncomms9745","journal-title":"Nat Commun"},{"issue":"1","key":"3_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0003-9861(84)90080-8","volume":"230","author":"TP King","year":"1984","unstructured":"King TP, Kochoumian L, Joslyn A (1984) Wasp venom proteins: phospholipase A1 and B. Arch Biochem Biophys 230(1):1\u201312. https:\/\/doi.org\/10.1016\/0003-9861(84)90080-8","journal-title":"Arch Biochem Biophys"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.toxicon.2016.11.006","volume":"124","author":"A Perez-Riverol","year":"2016","unstructured":"Perez-Riverol A, Campos Pereira FD, Musacchio Lasa A, Romani Fernandes LG, Santos-Pinto JR, Justo-Jacomini DL, Oliveira de Azevedo G, Bazon ML, Palma MS, Zollner RL, Brochetto-Braga MR (2016) Molecular cloning, expression and IgE-immunoreactivity of phospholipase A1, a major allergen from Polybia paulista (Hymenoptera: Vespidae) venom. Toxicon 124:44\u201352. https:\/\/doi.org\/10.1016\/j.toxicon.2016.11.006","journal-title":"Toxicon"},{"issue":"10","key":"3_CR15","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1105\/tpc.13.10.2191","volume":"13","author":"S Ishiguro","year":"2001","unstructured":"Ishiguro S, Kawai-Oda A, Ueda J, Nishida I, Okada K (2001) The DEFECTIVE IN ANTHER DEHISCIENCE gene encodes a novel phospholipase A1 catalyzing the initial step of jasmonic acid biosynthesis, which synchronizes pollen maturation, anther dehiscence, and flower opening in Arabidopsis. Plant Cell 13(10):2191\u20132209","journal-title":"Plant Cell"},{"issue":"18","key":"3_CR16","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1111\/j.1432-1033.2004.04317.x","volume":"271","author":"A Noiriel","year":"2004","unstructured":"Noiriel A, Benveniste P, Banas A, Stymne S, Bouvier-Nave P (2004) Expression in yeast of a novel phospholipase A1 cDNA from Arabidopsis thaliana. Eur J Biochem 271(18):3752\u20133764. https:\/\/doi.org\/10.1111\/j.1432-1033.2004.04317.x","journal-title":"Eur J Biochem"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1105\/tpc.17.00397","volume":"29","author":"K Wang","year":"2017","unstructured":"Wang K, Froehlich JE, Zienkiewicz A, Hersh HL, Benning C (2017) A plastid phosphatidylglycerol lipase contributes to the export of acyl groups from plastids for seed oil biosynthesis. Plant Cell 29:1678\u20131696. https:\/\/doi.org\/10.1105\/tpc.17.00397","journal-title":"Plant Cell"},{"issue":"3","key":"3_CR18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0304-4157(98)00016-1","volume":"1376","author":"F Carriere","year":"1998","unstructured":"Carriere F, Withers-Martinez C, van Tilbeurgh H, Roussel A, Cambillau C, Verger R (1998) Structural basis for the substrate selectivity of pancreatic lipases and some related proteins. Biochim Biophys Acta 1376(3):417\u2013432","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"3_CR19","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0969-2126(96)00143-8","volume":"4","author":"C Withers-Martinez","year":"1996","unstructured":"Withers-Martinez C, Carriere F, Verger R, Bourgeois D, Cambillau C (1996) A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig. Structure 4(11):1363\u20131374","journal-title":"Structure"},{"issue":"11","key":"3_CR20","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.bbalip.2012.07.014","volume":"1821","author":"S Amara","year":"2012","unstructured":"Amara S, Delorme V, Record M, Carriere F (2012) Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP). Biochim Biophys Acta 1821(11):1379\u20131385. https:\/\/doi.org\/10.1016\/j.bbalip.2012.07.014","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3_CR21","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.bbalip.2013.12.009","volume":"1841","author":"A Aloulou","year":"2013","unstructured":"Aloulou A, Frikha F, Noiriel A, Bou Ali M, Abousalham A (2013) Kinetic and structural characterization of triacylglycerol lipases possessing phospholipase A1 activity. Biochim Biophys Acta 1841(4):581\u2013587. https:\/\/doi.org\/10.1016\/j.bbalip.2013.12.009","journal-title":"Biochim Biophys Acta"},{"issue":"1-2","key":"3_CR22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-3084(98)00026-7","volume":"93","author":"JW Simons","year":"1998","unstructured":"Simons JW, Gotz F, Egmond MR, Verheij HM (1998) Biochemical properties of staphylococcal (phospho)lipases. Chem Phys Lipids 93(1-2):27\u201337","journal-title":"Chem Phys Lipids"},{"issue":"2","key":"3_CR23","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jmb.2007.05.041","volume":"371","author":"JJ Tiesinga","year":"2007","unstructured":"Tiesinga JJ, van Pouderoyen G, Nardini M, Ransac S, Dijkstra BW (2007) Structural basis of phospholipase activity of Staphylococcus hyicus lipase. J Mol Biol 371(2):447\u2013456. https:\/\/doi.org\/10.1016\/j.jmb.2007.05.041","journal-title":"J Mol Biol"},{"issue":"Suppl","key":"3_CR24","doi-asserted-by":"publisher","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","volume":"50","author":"JE Burke","year":"2009","unstructured":"Burke JE, Dennis EA (2009) Phospholipase A2 structure\/function, mechanism, and signaling. J Lipid Res 50(Suppl):S237\u2013S242. https:\/\/doi.org\/10.1194\/jlr.R800033-JLR200","journal-title":"J Lipid Res"},{"issue":"1","key":"3_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10557-008-6132-9","volume":"23","author":"JE Burke","year":"2009","unstructured":"Burke JE, Dennis EA (2009) Phospholipase A2 biochemistry. Cardiovasc Drugs Ther 23(1):49\u201359. https:\/\/doi.org\/10.1007\/s10557-008-6132-9","journal-title":"Cardiovasc Drugs Ther"},{"issue":"2","key":"3_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.plipres.2010.12.001","volume":"50","author":"M Murakami","year":"2011","unstructured":"Murakami M, Taketomi Y, Miki Y, Sato H, Hirabayashi T, Yamamoto K (2011) Recent progress in phospholipase A(2) research: from cells to animals to humans. Prog Lipid Res 50(2):152\u2013192. https:\/\/doi.org\/10.1016\/j.plipres.2010.12.001","journal-title":"Prog Lipid Res"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/112_0507","volume":"160","author":"R Rivera","year":"2008","unstructured":"Rivera R, Chun J (2008) Biological effects of lysophospholipids. Rev Physiol Biochem Pharmacol 160:25\u201346. https:\/\/doi.org\/10.1007\/112_0507","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"10","key":"3_CR28","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1021\/cr200085w","volume":"111","author":"EA Dennis","year":"2011","unstructured":"Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G (2011) Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev 111(10):6130\u20136185. https:\/\/doi.org\/10.1021\/cr200085w","journal-title":"Chem Rev"},{"issue":"11","key":"3_CR29","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.bbalip.2006.07.011","volume":"1761","author":"RH Schaloske","year":"2006","unstructured":"Schaloske RH, Dennis EA (2006) The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta 1761(11):1246\u20131259. https:\/\/doi.org\/10.1016\/j.bbalip.2006.07.011","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"3_CR30","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1194\/jlr.R058123","volume":"56","author":"M Murakami","year":"2015","unstructured":"Murakami M, Sato H, Miki Y, Yamamoto K, Taketomi Y (2015) A new era of secreted phospholipase A(2). J Lipid Res 56(7):1248\u20131261. https:\/\/doi.org\/10.1194\/jlr.R058123","journal-title":"J Lipid Res"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.biochem.76.062405.154007","volume":"77","author":"G Lambeau","year":"2008","unstructured":"Lambeau G, Gelb MH (2008) Biochemistry and physiology of mammalian secreted phospholipases A2. Annu Rev Biochem 77:495\u2013520. https:\/\/doi.org\/10.1146\/annurev.biochem.76.062405.154007","journal-title":"Annu Rev Biochem"},{"issue":"39","key":"3_CR32","doi-asserted-by":"publisher","first-page":"11494","DOI":"10.1021\/bi0349930","volume":"42","author":"M Rouault","year":"2003","unstructured":"Rouault M, Bollinger JG, Lazdunski M, Gelb MH, Lambeau G (2003) Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry 42(39):11494\u201311503. https:\/\/doi.org\/10.1021\/bi0349930","journal-title":"Biochemistry"},{"issue":"11","key":"3_CR33","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1074\/jbc.275.11.7492","volume":"275","author":"E Valentin","year":"2000","unstructured":"Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G (2000) Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme. J Biol Chem 275(11):7492\u20137496","journal-title":"J Biol Chem"},{"issue":"32","key":"3_CR34","doi-asserted-by":"publisher","first-page":"29,086","DOI":"10.1074\/jbc.M202531200","volume":"277","author":"YH Pan","year":"2002","unstructured":"Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ (2002) Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. J Biol Chem 277(32):29,086\u201329,093. https:\/\/doi.org\/10.1074\/jbc.M202531200","journal-title":"J Biol Chem"},{"issue":"52","key":"3_CR35","doi-asserted-by":"crossref","first-page":"15468","DOI":"10.1021\/bi020485z","volume":"41","author":"SH Edwards","year":"2002","unstructured":"Edwards SH, Thompson D, Baker SF, Wood SP, Wilton DC (2002) The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism. Biochemistry 41(52):15468\u201315476","journal-title":"Biochemistry"},{"issue":"50","key":"3_CR36","doi-asserted-by":"publisher","first-page":"48,535","DOI":"10.1074\/jbc.M205855200","volume":"277","author":"AG Singer","year":"2002","unstructured":"Singer AG, Ghomashchi F, Le Calvez C, Bollinger J, Bezzine S, Rouault M, Sadilek M, Nguyen E, Lazdunski M, Lambeau G, Gelb MH (2002) Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2. J Biol Chem 277(50):48,535\u201348,549. https:\/\/doi.org\/10.1074\/jbc.M205855200","journal-title":"J Biol Chem"},{"issue":"1-2","key":"3_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbalip.2007.12.001","volume":"1781","author":"TJ Nevalainen","year":"2008","unstructured":"Nevalainen TJ, Graham GG, Scott KF (2008) Antibacterial actions of secreted phospholipases A2. Review. Biochim Biophys Acta 1781(1-2):1\u20139. https:\/\/doi.org\/10.1016\/j.bbalip.2007.12.001","journal-title":"Biochim Biophys Acta"},{"issue":"5034","key":"3_CR38","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1948070","volume":"254","author":"DL Scott","year":"1991","unstructured":"Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigler PB (1991) Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. Science 254(5034):1007\u20131010","journal-title":"Science"},{"issue":"11","key":"3_CR39","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.bbalip.2007.09.006","volume":"1771","author":"M Mitsuishi","year":"2007","unstructured":"Mitsuishi M, Masuda S, Kudo I, Murakami M (2007) Human group III phospholipase A2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A2s act on distinct cellular phospholipid molecular species. Biochim Biophys Acta 1771(11):1389\u20131396. https:\/\/doi.org\/10.1016\/j.bbalip.2007.09.006","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3_CR40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbalip.2005.07.005","volume":"1736","author":"W Pruzanski","year":"2005","unstructured":"Pruzanski W, Lambeau L, Lazdunsky M, Cho W, Kopilov J, Kuksis A (2005) Differential hydrolysis of molecular species of lipoprotein phosphatidylcholine by groups IIA, V and X secretory phospholipases A2. Biochim Biophys Acta 1736(1):38\u201350. https:\/\/doi.org\/10.1016\/j.bbalip.2005.07.005","journal-title":"Biochim Biophys Acta"},{"issue":"42","key":"3_CR41","doi-asserted-by":"publisher","first-page":"36,509","DOI":"10.1074\/jbc.M111.268540","volume":"286","author":"I Jemel","year":"2011","unstructured":"Jemel I, Ii H, Oslund RC, Payre C, Dabert-Gay AS, Douguet D, Chargui K, Scarzello S, Gelb MH, Lambeau G (2011) Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells. J Biol Chem 286(42):36,509\u201336,521. https:\/\/doi.org\/10.1074\/jbc.M111.268540","journal-title":"J Biol Chem"},{"issue":"Pt A","key":"3_CR42","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.biochi.2014.09.003","volume":"107","author":"M Murakami","year":"2014","unstructured":"Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K, Lambeau G (2014) Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition. Biochimie 107(Pt A):105\u2013113. https:\/\/doi.org\/10.1016\/j.biochi.2014.09.003","journal-title":"Biochimie"},{"issue":"6","key":"3_CR43","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.biochi.2010.03.015","volume":"92","author":"M Murakami","year":"2010","unstructured":"Murakami M, Taketomi Y, Girard C, Yamamoto K, Lambeau G (2010) Emerging roles of secreted phospholipase A2 enzymes: lessons from transgenic and knockout mice. Biochimie 92(6):561\u2013582. https:\/\/doi.org\/10.1016\/j.biochi.2010.03.015","journal-title":"Biochimie"},{"issue":"24","key":"3_CR44","doi-asserted-by":"publisher","first-page":"16,245","DOI":"10.1074\/jbc.M513874200","volume":"281","author":"Z Ni","year":"2006","unstructured":"Ni Z, Okeley NM, Smart BP, Gelb MH (2006) Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. J Biol Chem 281(24):16,245\u201316,255. https:\/\/doi.org\/10.1074\/jbc.M513874200","journal-title":"J Biol Chem"},{"issue":"24","key":"3_CR45","doi-asserted-by":"publisher","first-page":"25,024","DOI":"10.1074\/jbc.M313019200","volume":"279","author":"CM Mounier","year":"2004","unstructured":"Mounier CM, Ghomashchi F, Lindsay MR, James S, Singer AG, Parton RG, Gelb MH (2004) Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha. J Biol Chem 279(24):25,024\u201325,038. https:\/\/doi.org\/10.1074\/jbc.M313019200","journal-title":"J Biol Chem"},{"issue":"5","key":"3_CR46","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1074\/jbc.275.5.3179","volume":"275","author":"S Bezzine","year":"2000","unstructured":"Bezzine S, Koduri RS, Valentin E, Murakami M, Kudo I, Ghomashchi F, Sadilek M, Lambeau G, Gelb MH (2000) Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. J Biol Chem 275(5):3179\u20133191","journal-title":"J Biol Chem"},{"issue":"8","key":"3_CR47","doi-asserted-by":"publisher","first-page":"5849","DOI":"10.1074\/jbc.M109699200","volume":"277","author":"RS Koduri","year":"2002","unstructured":"Koduri RS, Gronroos JO, Laine VJ, Le Calvez C, Lambeau G, Nevalainen TJ, Gelb MH (2002) Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). J Biol Chem 277(8):5849\u20135857. https:\/\/doi.org\/10.1074\/jbc.M109699200","journal-title":"J Biol Chem"},{"issue":"3","key":"3_CR48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.mol.0000169355.20395.55","volume":"16","author":"NR Webb","year":"2005","unstructured":"Webb NR (2005) Secretory phospholipase A2 enzymes in atherogenesis. Curr Opin Lipidol 16(3):341\u2013344","journal-title":"Curr Opin Lipidol"},{"issue":"6","key":"3_CR49","doi-asserted-by":"publisher","first-page":"L879","DOI":"10.1152\/ajplung.90580.2008","volume":"296","author":"NM Munoz","year":"2009","unstructured":"Munoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR (2009) Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am J Physiol Lung Cell Mol Physiol 296(6):L879\u2013L887. https:\/\/doi.org\/10.1152\/ajplung.90580.2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"3_CR50","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/emmm.201000072","volume":"2","author":"E Boilard","year":"2010","unstructured":"Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, Arm JP, Lee DM (2010) A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis. EMBO Mol Med 2(5):172\u2013187. https:\/\/doi.org\/10.1002\/emmm.201000072","journal-title":"EMBO Mol Med"},{"issue":"6","key":"3_CR51","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.plipres.2006.05.003","volume":"45","author":"M Ghosh","year":"2006","unstructured":"Ghosh M, Tucker DE, Burchett SA, Leslie CC (2006) Properties of the Group IV phospholipase A2 family. Prog Lipid Res 45(6):487\u2013510. https:\/\/doi.org\/10.1016\/j.plipres.2006.05.003","journal-title":"Prog Lipid Res"},{"issue":"8","key":"3_CR52","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1194\/jlr.R057588","volume":"56","author":"CC Leslie","year":"2015","unstructured":"Leslie CC (2015) Cytosolic phospholipase A(2): physiological function and role in disease. J Lipid Res 56(8):1386\u20131402. https:\/\/doi.org\/10.1194\/jlr.R057588","journal-title":"J Lipid Res"},{"issue":"26","key":"3_CR53","doi-asserted-by":"publisher","first-page":"24,576","DOI":"10.1074\/jbc.M413711200","volume":"280","author":"T Ohto","year":"2005","unstructured":"Ohto T, Uozumi N, Hirabayashi T, Shimizu T (2005) Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. J Biol Chem 280(26):24,576\u201324,583. https:\/\/doi.org\/10.1074\/jbc.M413711200","journal-title":"J Biol Chem"},{"issue":"46","key":"3_CR54","doi-asserted-by":"publisher","first-page":"36,100","DOI":"10.1074\/jbc.M110.165647","volume":"285","author":"F Ghomashchi","year":"2010","unstructured":"Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH (2010) Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms. J Biol Chem 285(46):36,100\u201336,111. https:\/\/doi.org\/10.1074\/jbc.M110.165647","journal-title":"J Biol Chem"},{"issue":"24","key":"3_CR55","doi-asserted-by":"publisher","first-page":"16,615","DOI":"10.1074\/jbc.M601770200","volume":"281","author":"M Ghosh","year":"2006","unstructured":"Ghosh M, Loper R, Gelb MH, Leslie CC (2006) Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. J Biol Chem 281(24):16,615\u201316,624. https:\/\/doi.org\/10.1074\/jbc.M601770200","journal-title":"J Biol Chem"},{"issue":"16","key":"3_CR56","doi-asserted-by":"publisher","first-page":"11,676","DOI":"10.1074\/jbc.M608458200","volume":"282","author":"M Ghosh","year":"2007","unstructured":"Ghosh M, Loper R, Ghomashchi F, Tucker DE, Bonventre JV, Gelb MH, Leslie CC (2007) Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem 282(16):11,676\u201311,686. https:\/\/doi.org\/10.1074\/jbc.M608458200","journal-title":"J Biol Chem"},{"issue":"35","key":"3_CR57","doi-asserted-by":"publisher","first-page":"12,746","DOI":"10.1073\/pnas.1404372111","volume":"111","author":"PC Norris","year":"2014","unstructured":"Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA (2014) Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A 111(35):12,746\u201312,751. https:\/\/doi.org\/10.1073\/pnas.1404372111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/o03-080o03-080","volume":"82","author":"CC Leslie","year":"2004","unstructured":"Leslie CC (2004) Regulation of arachidonic acid availability for eicosanoid production. Biochem Cell Biol 82(1):1\u201317. https:\/\/doi.org\/10.1139\/o03-080o03-080","journal-title":"Biochem Cell Biol"},{"issue":"4","key":"3_CR59","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.plefa.2003.12.012","volume":"70","author":"CC Leslie","year":"2004","unstructured":"Leslie CC (2004) Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2. Prostaglandins Leukot Essent Fatty Acids 70(4):373\u2013376. https:\/\/doi.org\/10.1016\/j.plefa.2003.12.012","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"7","key":"3_CR60","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1194\/jlr.M037382","volume":"54","author":"JS Bickford","year":"2013","unstructured":"Bickford JS, Beachy DE, Newsom KJ, Barilovits SJ, Herlihy JD, Qiu X, Walters JN, Li N, Nick HS (2013) A distal enhancer controls cytokine-dependent human cPLA2alpha gene expression. J Lipid Res 54(7):1915\u20131926. https:\/\/doi.org\/10.1194\/jlr.M037382","journal-title":"J Lipid Res"},{"issue":"8","key":"3_CR61","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/jcp.22537","volume":"226","author":"CW Lee","year":"2011","unstructured":"Lee CW, Lin CC, Lee IT, Lee HC, Yang CM (2011) Activation and induction of cytosolic phospholipase A2 by TNF-alpha mediated through Nox2, MAPKs, NF-kappaB, and p300 in human tracheal smooth muscle cells. J Cell Physiol 226(8):2103\u20132114. https:\/\/doi.org\/10.1002\/jcp.22537","journal-title":"J Cell Physiol"},{"issue":"6","key":"3_CR62","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.biochi.2010.03.001","volume":"92","author":"CC Leslie","year":"2010","unstructured":"Leslie CC, Gangelhoff TA, Gelb MH (2010) Localization and function of cytosolic phospholipase A2alpha at the Golgi. Biochimie 92(6):620\u2013626. https:\/\/doi.org\/10.1016\/j.biochi.2010.03.001","journal-title":"Biochimie"},{"issue":"32","key":"3_CR63","doi-asserted-by":"publisher","first-page":"30,150","DOI":"10.1074\/jbc.M100943200","volume":"276","author":"JH Evans","year":"2001","unstructured":"Evans JH, Spencer DM, Zweifach A, Leslie CC (2001) Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes. J Biol Chem 276(32):30,150\u201330,160. https:\/\/doi.org\/10.1074\/jbc.M100943200","journal-title":"J Biol Chem"},{"issue":"8","key":"3_CR64","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1248\/bpb.27.1168","volume":"27","author":"T Hirabayashi","year":"2004","unstructured":"Hirabayashi T, Murayama T, Shimizu T (2004) Regulatory mechanism and physiological role of cytosolic phospholipase A2. Biol Pharm Bull 27(8):1168\u20131173. https:\/\/doi.org\/10.1248\/bpb.27.1168","journal-title":"Biol Pharm Bull"},{"issue":"21","key":"3_CR65","doi-asserted-by":"crossref","first-page":"14,979","DOI":"10.1074\/jbc.274.21.14979","volume":"274","author":"O Perisic","year":"1999","unstructured":"Perisic O, Paterson HF, Mosedale G, Lara-Gonzalez S, Williams RL (1999) Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2. J Biol Chem 274(21):14,979\u201314,987","journal-title":"J Biol Chem"},{"issue":"12","key":"3_CR66","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1073\/pnas.96.12.6637","volume":"96","author":"A Ball","year":"1999","unstructured":"Ball A, Nielsen R, Gelb MH, Robinson BH (1999) Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance. Proc Natl Acad Sci U S A 96(12):6637\u20136642","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"40","key":"3_CR67","doi-asserted-by":"publisher","first-page":"12,011","DOI":"10.1021\/bi9717340","volume":"36","author":"EA Nalefski","year":"1997","unstructured":"Nalefski EA, Slazas MM, Falke JJ (1997) Ca2+-signaling cycle of a membrane-docking C2 domain. Biochemistry 36(40):12,011\u201312,018. https:\/\/doi.org\/10.1021\/bi9717340","journal-title":"Biochemistry"},{"issue":"1","key":"3_CR68","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1091\/mbc.E03-05-0338","volume":"15","author":"JH Evans","year":"2004","unstructured":"Evans JH, Gerber SH, Murray D, Leslie CC (2004) The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol Biol Cell 15(1):371\u2013383. https:\/\/doi.org\/10.1091\/mbc.E03-05-0338","journal-title":"Mol Biol Cell"},{"issue":"1","key":"3_CR69","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1091\/mbc.E05-06-0499","volume":"17","author":"JH Evans","year":"2006","unstructured":"Evans JH, Murray D, Leslie CC, Falke JJ (2006) Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Mol Biol Cell 17(1):56\u201366. https:\/\/doi.org\/10.1091\/mbc.E05-06-0499","journal-title":"Mol Biol Cell"},{"issue":"45","key":"3_CR70","doi-asserted-by":"publisher","first-page":"31,227","DOI":"10.1074\/jbc.M804492200","volume":"283","author":"JE Burke","year":"2008","unstructured":"Burke JE, Hsu YH, Deems RA, Li S, Woods VL Jr, Dennis EA (2008) A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem 283(45):31,227\u201331,236. https:\/\/doi.org\/10.1074\/jbc.M804492200","journal-title":"J Biol Chem"},{"issue":"7","key":"3_CR71","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.1074\/jbc.M311246200","volume":"279","author":"JH Evans","year":"2004","unstructured":"Evans JH, Leslie CC (2004) The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes. J Biol Chem 279(7):6005\u20136016. https:\/\/doi.org\/10.1074\/jbc.M311246200","journal-title":"J Biol Chem"},{"issue":"4","key":"3_CR72","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1194\/jlr.M700419-JLR200","volume":"49","author":"Z Pavicevic","year":"2008","unstructured":"Pavicevic Z, Leslie CC, Malik KU (2008) cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. J Lipid Res 49(4):724\u2013737. https:\/\/doi.org\/10.1194\/jlr.M700419-JLR200","journal-title":"J Lipid Res"},{"issue":"14","key":"3_CR73","doi-asserted-by":"publisher","first-page":"9596","DOI":"10.1074\/jbc.M807299200","volume":"284","author":"DE Tucker","year":"2009","unstructured":"Tucker DE, Ghosh M, Ghomashchi F, Loper R, Suram S, John BS, Girotti M, Bollinger JG, Gelb MH, Leslie CC (2009) Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. J Biol Chem 284(14):9596\u20139611. https:\/\/doi.org\/10.1074\/jbc.M807299200","journal-title":"J Biol Chem"},{"issue":"42","key":"3_CR74","doi-asserted-by":"crossref","first-page":"41431","DOI":"10.1074\/jbc.M304897200","volume":"278","author":"S Das","year":"2003","unstructured":"Das S, Rafter JD, Kim KP, Gygi SP, Cho W (2003) Mechanism of group IVA cytosolic phospholipase A activation by phosphorylation. J Biol Chem 278(42):41431\u201341442","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR75","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1091\/mbc.E05-06-0545","volume":"17","author":"J Casas","year":"2006","unstructured":"Casas J, Gijon MA, Vigo AG, Crespo MS, Balsinde J, Balboa MA (2006) Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells. Mol Biol Cell 17(1):155\u2013162. https:\/\/doi.org\/10.1091\/mbc.E05-06-0545","journal-title":"Mol Biol Cell"},{"issue":"1\u20132","key":"3_CR76","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S1388-1981(00)00108-6","volume":"1488","author":"A Dessen","year":"2000","unstructured":"Dessen A (2000) Structure and mechanism of human cytosolic phospholipase A(2). Biochim Biophys Acta 1488(1\u20132):40\u201347. https:\/\/doi.org\/10.1016\/S1388-1981(00)00108-6","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"3_CR77","doi-asserted-by":"publisher","first-page":"7519","DOI":"10.1074\/jbc.M407438200","volume":"280","author":"BB Rubin","year":"2005","unstructured":"Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH (2005) Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem 280(9):7519\u20137529. https:\/\/doi.org\/10.1074\/jbc.M407438200","journal-title":"J Biol Chem"},{"issue":"4","key":"3_CR78","doi-asserted-by":"crossref","first-page":"F607","DOI":"10.1152\/ajprenal.2001.280.4.F607","volume":"280","author":"P Downey","year":"2001","unstructured":"Downey P, Sapirstein A, O\u2019Leary E, Sun TX, Brown D, Bonventre JV (2001) Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). Am J Physiol Renal Physiol 280(4):F607\u2013F618","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"3_CR79","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1084\/jem.20011443","volume":"196","author":"DA Wong","year":"2002","unstructured":"Wong DA, Kita Y, Uozumi N, Shimizu T (2002) Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2). J Exp Med 196(3):349\u2013357","journal-title":"J Exp Med"},{"issue":"10","key":"3_CR80","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1021\/bi101877n","volume":"50","author":"KA Reed","year":"2011","unstructured":"Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O (2011) Functional characterization of mutations in inherited human cPLA(2) deficiency. Biochemistry 50(10):1731\u20131738. https:\/\/doi.org\/10.1021\/bi101877n","journal-title":"Biochemistry"},{"issue":"1","key":"3_CR81","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/gutjnl-2012-303581","volume":"63","author":"MA Brooke","year":"2014","unstructured":"Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Ruschendorf F, Warner TD, Kelsell DP, MacDonald TT (2014) Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-alpha. Gut 63(1):96\u2013104. https:\/\/doi.org\/10.1136\/gutjnl-2012-303581","journal-title":"Gut"},{"issue":"6","key":"3_CR82","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1160\/TH14-04-0352","volume":"112","author":"EM Faioni","year":"2014","unstructured":"Faioni EM, Razzari C, Zulueta A, Femia EA, Fenu L, Trinchera M, Podda GM, Pugliano M, Marongiu F, Cattaneo M (2014) Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency. Thromb Haemost 112(6):1182\u20131189. https:\/\/doi.org\/10.1160\/TH14-04-0352","journal-title":"Thromb Haemost"},{"issue":"6","key":"3_CR83","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1172\/JCI30473","volume":"118","author":"DH Adler","year":"2008","unstructured":"Adler DH, Cogan JD, Phillips JA 3rd, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA (2008) Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest 118(6):2121\u20132131. https:\/\/doi.org\/10.1172\/JCI30473","journal-title":"J Clin Invest"},{"issue":"7","key":"3_CR84","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/nm891","volume":"9","author":"S Haq","year":"2003","unstructured":"Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T (2003) Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nat Med 9(7):944\u2013951. https:\/\/doi.org\/10.1038\/nm891","journal-title":"Nat Med"},{"issue":"5","key":"3_CR85","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nm0502-480","volume":"8","author":"T Nagase","year":"2002","unstructured":"Nagase T, Uozumi N, Ishii S, Kita Y, Yamamoto H, Ohga E, Ouchi Y, Shimizu T (2002) A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med 8(5):480\u2013484. https:\/\/doi.org\/10.1038\/nm0502-480","journal-title":"Nat Med"},{"issue":"10","key":"3_CR86","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1084\/jem.20030015","volume":"197","author":"C Miyaura","year":"2003","unstructured":"Miyaura C, Inada M, Matsumoto C, Ohshiba T, Uozumi N, Shimizu T, Ito A (2003) An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation. J Exp Med 197(10):1303\u20131310. https:\/\/doi.org\/10.1084\/jem.20030015","journal-title":"J Exp Med"},{"issue":"10","key":"3_CR87","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1084\/jem.20030016","volume":"197","author":"M Hegen","year":"2003","unstructured":"Hegen M, Sun L, Uozumi N, Kume K, Goad ME, Nickerson-Nutter CL, Shimizu T, Clark JD (2003) Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J Exp Med 197(10):1297\u20131302. https:\/\/doi.org\/10.1084\/jem.20030016","journal-title":"J Exp Med"},{"issue":"3","key":"3_CR88","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.it.2004.01.006","volume":"25","author":"J Bonventre","year":"2004","unstructured":"Bonventre J (2004) Cytosolic phospholipase A2alpha reigns supreme in arthritis and bone resorption. Trends Immunol 25(3):116\u2013119","journal-title":"Trends Immunol"},{"issue":"11","key":"3_CR89","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/nn.2213","volume":"11","author":"RO Sanchez-Mejia","year":"2008","unstructured":"Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L (2008) Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer\u2019s disease. Nat Neurosci 11(11):1311\u20131318. https:\/\/doi.org\/10.1038\/nn.2213","journal-title":"Nat Neurosci"},{"issue":"1","key":"3_CR90","doi-asserted-by":"publisher","first-page":"L105","DOI":"10.1152\/ajplung.00221.2005","volume":"290","author":"JM Hartney","year":"2006","unstructured":"Hartney JM, Coggins KG, Tilley SL, Jania LA, Lovgren AK, Audoly LP, Koller BH (2006) Prostaglandin E2 protects lower airways against bronchoconstriction. Am J Physiol Lung Cell Mol Physiol 290(1):L105\u2013L113. https:\/\/doi.org\/10.1152\/ajplung.00221.2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"3_CR91","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.cmet.2005.08.005","volume":"2","author":"H Francois","year":"2005","unstructured":"Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim HS, Rockman HA, Fitzgerald GA, Koller BH, Coffman TM (2005) Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab 2(3):201\u2013207. https:\/\/doi.org\/10.1016\/j.cmet.2005.08.005","journal-title":"Cell Metab"},{"issue":"7","key":"3_CR92","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1158\/0008-5472.CAN-04-3446","volume":"65","author":"JN Ilsley","year":"2005","unstructured":"Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW (2005) Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Res 65(7):2636\u20132643. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-3446","journal-title":"Cancer Res"},{"issue":"8","key":"3_CR93","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1093\/carcin\/bgh150","volume":"25","author":"AM Meyer","year":"2004","unstructured":"Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM (2004) Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis 25(8):1517\u20131524. https:\/\/doi.org\/10.1093\/carcin\/bgh150","journal-title":"Carcinogenesis"},{"issue":"9","key":"3_CR94","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1194\/jlr.R058701","volume":"56","author":"S Ramanadham","year":"2015","unstructured":"Ramanadham S, Ali T, Ashley JW, Bone RN, Hancock WD, Lei X (2015) Calcium-independent phospholipases A2 and their roles in biological processes and diseases. J Lipid Res 56(9):1643\u20131668. https:\/\/doi.org\/10.1194\/jlr.R058701","journal-title":"J Lipid Res"},{"issue":"1","key":"3_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0968-0004(96)20031-3","volume":"22","author":"EA Dennis","year":"1997","unstructured":"Dennis EA (1997) The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem Sci 22(1):1\u20132. https:\/\/doi.org\/10.1016\/S0968-0004(96)20031-3","journal-title":"Trends Biochem Sci"},{"issue":"Suppl","key":"3_CR96","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1194\/jlr.R800082-JLR200","volume":"50","author":"PC Kienesberger","year":"2009","unstructured":"Kienesberger PC, Oberer M, Lass A, Zechner R (2009) Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res 50(Suppl):S63\u2013S68. https:\/\/doi.org\/10.1194\/jlr.R800082-JLR200","journal-title":"J Lipid Res"},{"issue":"9","key":"3_CR97","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1194\/jlr.M600185-JLR200","volume":"47","author":"PA Wilson","year":"2006","unstructured":"Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (2006) Characterization of the human patatin-like phospholipase family. J Lipid Res 47(9):1940\u20131949. https:\/\/doi.org\/10.1194\/jlr.M600185-JLR200","journal-title":"J Lipid Res"},{"issue":"47","key":"3_CR98","doi-asserted-by":"publisher","first-page":"48,968","DOI":"10.1074\/jbc.M407841200","volume":"279","author":"CM Jenkins","year":"2004","unstructured":"Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279(47):48,968\u201348,975. https:\/\/doi.org\/10.1074\/jbc.M407841200","journal-title":"J Biol Chem"},{"issue":"2-3","key":"3_CR99","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0005-2760(98)00049-6","volume":"1392","author":"YC Lio","year":"1998","unstructured":"Lio YC, Dennis EA (1998) Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta 1392(2-3):320\u2013332","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"3_CR100","doi-asserted-by":"publisher","first-page":"15,615","DOI":"10.1074\/jbc.M511623200","volume":"281","author":"CM Jenkins","year":"2006","unstructured":"Jenkins CM, Yan W, Mancuso DJ, Gross RW (2006) Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity. J Biol Chem 281(23):15,615\u201315,624. https:\/\/doi.org\/10.1074\/jbc.M511623200","journal-title":"J Biol Chem"},{"issue":"46","key":"3_CR101","doi-asserted-by":"publisher","first-page":"12,241","DOI":"10.1021\/bi800923s","volume":"47","author":"MJ Carper","year":"2008","unstructured":"Carper MJ, Zhang S, Turk J, Ramanadham S (2008) Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation. Biochemistry 47(46):12,241\u201312,249. https:\/\/doi.org\/10.1021\/bi800923s","journal-title":"Biochemistry"},{"key":"3_CR102","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.bbalip.2016.06.007","volume":"1861","author":"M Hermansson","year":"2016","unstructured":"Hermansson M, H\u00e4nninen S, Hokynar K, Somerharju P (2016) The PNPLA-family phospholipases involved in glycerophospholipid homeostasis of HeLa cells. Biochim Biophys Acta 1861:1058\u20131065. https:\/\/doi.org\/10.1016\/j.bbalip.2016.06.007","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"3_CR103","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2174\/138945008785132385","volume":"9","author":"WP Wilkins 3rd","year":"2008","unstructured":"Wilkins WP 3rd, Barbour SE (2008) Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics. Curr Drug Targets 9(8):683\u2013697","journal-title":"Curr Drug Targets"},{"issue":"3","key":"3_CR104","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1124\/pr.58.3.7","volume":"58","author":"AA Farooqui","year":"2006","unstructured":"Farooqui AA, Ong WY, Horrocks LA (2006) Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev 58(3):591\u2013620. https:\/\/doi.org\/10.1124\/pr.58.3.7","journal-title":"Pharmacol Rev"},{"issue":"9","key":"3_CR105","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.bcp.2008.07.044","volume":"76","author":"SB Hooks","year":"2008","unstructured":"Hooks SB, Cummings BS (2008) Role of Ca2+-independent phospholipase A2 in cell growth and signaling. Biochem Pharmacol 76(9):1059\u20131067. https:\/\/doi.org\/10.1016\/j.bcp.2008.07.044","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"3_CR106","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.biochi.2010.03.019","volume":"92","author":"KF Scott","year":"2010","unstructured":"Scott KF, Sajinovic M, Hein J, Nixdorf S, Galettis P, Liauw W, de Souza P, Dong Q, Graham GG, Russell PJ (2010) Emerging roles for phospholipase A2 enzymes in cancer. Biochimie 92(6):601\u2013610. https:\/\/doi.org\/10.1016\/j.biochi.2010.03.019","journal-title":"Biochimie"},{"issue":"8","key":"3_CR107","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1248\/bpb.27.1174","volume":"27","author":"S Akiba","year":"2004","unstructured":"Akiba S, Sato T (2004) Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull 27(8):1174\u20131178. https:\/\/doi.org\/10.1248\/bpb.27.1174","journal-title":"Biol Pharm Bull"},{"issue":"9","key":"3_CR108","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.cellsig.2005.03.002","volume":"17","author":"J Balsinde","year":"2005","unstructured":"Balsinde J, Balboa MA (2005) Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells. Cell Signal 17(9):1052\u20131062. https:\/\/doi.org\/10.1016\/j.cellsig.2005.03.002","journal-title":"Cell Signal"},{"issue":"1","key":"3_CR109","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/bi00052a041","volume":"32","author":"RW Gross","year":"1993","unstructured":"Gross RW, Ramanadham S, Kruszka KK, Han X, Turk J (1993) Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells. Biochemistry 32(1):327\u2013336","journal-title":"Biochemistry"},{"issue":"5","key":"3_CR110","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bbalip.2010.01.006","volume":"1801","author":"H Song","year":"2010","unstructured":"Song H, Bao S, Lei X, Jin C, Zhang S, Turk J, Ramanadham S (2010) Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta. Biochim Biophys Acta 1801(5):547\u2013558. https:\/\/doi.org\/10.1016\/j.bbalip.2010.01.006","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3_CR111","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0005-2760(97)00128-8","volume":"1389","author":"YY Bahk","year":"1998","unstructured":"Bahk YY, Song H, Baek SH, Park BY, Kim H, Ryu SH, Suh PG (1998) Localization of two forms of phospholipase C-beta1, a and b, in C6Bu-1 cells. Biochim Biophys Acta 1389(1):76\u201380. https:\/\/doi.org\/10.1016\/S0005-2760(97)00128-8","journal-title":"Biochim Biophys Acta"},{"issue":"22","key":"3_CR112","doi-asserted-by":"crossref","first-page":"13,870","DOI":"10.1074\/jbc.273.22.13870","volume":"273","author":"G Atsumi","year":"1998","unstructured":"Atsumi G, Tajima M, Hadano A, Nakatani Y, Murakami M, Kudo I (1998) Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation. J Biol Chem 273(22):13,870\u201313,877","journal-title":"J Biol Chem"},{"issue":"26","key":"3_CR113","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1021\/bi100752u","volume":"49","author":"J Sharma","year":"2010","unstructured":"Sharma J, Turk J, McHowat J (2010) Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse. Biochemistry 49(26):5473\u20135481. https:\/\/doi.org\/10.1021\/bi100752u","journal-title":"Biochemistry"},{"issue":"29","key":"3_CR114","doi-asserted-by":"publisher","first-page":"26,669","DOI":"10.1074\/jbc.M502358200","volume":"280","author":"W Yan","year":"2005","unstructured":"Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW (2005) The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling. J Biol Chem 280(29):26,669\u201326,679. https:\/\/doi.org\/10.1074\/jbc.M502358200","journal-title":"J Biol Chem"},{"issue":"3","key":"3_CR115","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/humu.22743","volume":"36","author":"CJ Saunders","year":"2015","unstructured":"Saunders CJ, Moon SH, Liu X, Thiffault I, Coffman K, LePichon JB, Taboada E, Smith LD, Farrow EG, Miller N, Gibson M, Patterson M, Kingsmore SF, Gross RW (2015) Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase A2 gamma recapitulate the mitochondriopathy of the homologous null mouse. Hum Mutat 36(3):301\u2013306. https:\/\/doi.org\/10.1002\/humu.22743","journal-title":"Hum Mutat"},{"issue":"51","key":"3_CR116","doi-asserted-by":"publisher","first-page":"35,632","DOI":"10.1074\/jbc.M109.055194","volume":"284","author":"DJ Mancuso","year":"2009","unstructured":"Mancuso DJ, Kotzbauer P, Wozniak DF, Sims HF, Jenkins CM, Guan S, Han X, Yang K, Sun G, Malik I, Conyers S, Green KG, Schmidt RE, Gross RW (2009) Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction. J Biol Chem 284(51):35,632\u201335,644. https:\/\/doi.org\/10.1074\/jbc.M109.055194","journal-title":"J Biol Chem"},{"issue":"23","key":"3_CR117","doi-asserted-by":"publisher","first-page":"20,942","DOI":"10.1074\/jbc.M200330200","volume":"277","author":"M Tienhoven van","year":"2002","unstructured":"van Tienhoven M, Atkins J, Li Y, Glynn P (2002) Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem 277(23):20,942\u201320,948. https:\/\/doi.org\/10.1074\/jbc.M200330200","journal-title":"J Biol Chem"},{"issue":"36","key":"3_CR118","doi-asserted-by":"publisher","first-page":"33,336","DOI":"10.1074\/jbc.M105193200","volume":"276","author":"S Baulande","year":"2001","unstructured":"Baulande S, Lasnier F, Lucas M, Pairault J (2001) Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. J Biol Chem 276(36):33,336\u201333,344. https:\/\/doi.org\/10.1074\/jbc.M105193200","journal-title":"J Biol Chem"},{"issue":"14","key":"3_CR119","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1073\/pnas.0401030101","volume":"101","author":"K Akassoglou","year":"2004","unstructured":"Akassoglou K, Malester B, Xu J, Tessarollo L, Rosenbluth J, Chao MV (2004) Brain-specific deletion of neuropathy target esterase\/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A 101(14):5075\u20135080. https:\/\/doi.org\/10.1073\/pnas.0401030101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"3_CR120","doi-asserted-by":"publisher","first-page":"6706","DOI":"10.1074\/jbc.M109.064501","volume":"285","author":"S He","year":"2010","unstructured":"He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, Cohen JC, Hobbs HH (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 285(9):6706\u20136715. https:\/\/doi.org\/10.1074\/jbc.M109.064501","journal-title":"J Biol Chem"},{"issue":"5","key":"3_CR121","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/boc.201200036","volume":"105","author":"Z Chamoun","year":"2013","unstructured":"Chamoun Z, Vacca F, Parton RG, Gruenberg J (2013) PNPLA3\/adiponutrin functions in lipid droplet formation. Biol Cell 105(5):219\u2013233. https:\/\/doi.org\/10.1111\/boc.201200036","journal-title":"Biol Cell"},{"issue":"43","key":"3_CR122","doi-asserted-by":"publisher","first-page":"37,085","DOI":"10.1074\/jbc.M111.290114","volume":"286","author":"Y Huang","year":"2011","unstructured":"Huang Y, Cohen JC, Hobbs HH (2011) Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J Biol Chem 286(43):37,085\u201337,093. https:\/\/doi.org\/10.1074\/jbc.M111.290114","journal-title":"J Biol Chem"},{"issue":"5","key":"3_CR123","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.cmet.2012.04.008","volume":"15","author":"M Kumari","year":"2012","unstructured":"Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R (2012) Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 15(5):691\u2013702. https:\/\/doi.org\/10.1016\/j.cmet.2012.04.008","journal-title":"Cell Metab"},{"issue":"5","key":"3_CR124","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","volume":"3","author":"A Lass","year":"2006","unstructured":"Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, Kienesberger P, Strauss JG, Gorkiewicz G, Zechner R (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 3(5):309\u2013319. https:\/\/doi.org\/10.1016\/j.cmet.2006.03.005","journal-title":"Cell Metab"},{"issue":"6","key":"3_CR125","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bbalip.2008.10.012","volume":"1791","author":"T Yamaguchi","year":"2009","unstructured":"Yamaguchi T, Osumi T (2009) Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase. Biochim Biophys Acta 1791(6):519\u2013523. https:\/\/doi.org\/10.1016\/j.bbalip.2008.10.012","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3_CR126","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bbrc.2013.07.063","volume":"438","author":"T Inoue","year":"2013","unstructured":"Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Maeda Y, Hirata E, Fujimura Y, Miura D, Hirano K, Takayanagi R (2013) Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db\/db mice. Biochem Biophys Res Commun 438(1):224\u2013229. https:\/\/doi.org\/10.1016\/j.bbrc.2013.07.063","journal-title":"Biochem Biophys Res Commun"},{"issue":"5774","key":"3_CR127","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1126\/science.1123965","volume":"312","author":"G Haemmerle","year":"2006","unstructured":"Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312(5774):734\u2013737. https:\/\/doi.org\/10.1126\/science.1123965","journal-title":"Science"},{"key":"3_CR128","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.17","volume":"3","author":"E Aflaki","year":"2012","unstructured":"Aflaki E, Doddapattar P, Radovic B, Povoden S, Kolb D, Vujic N, Wegscheider M, Koefeler H, Hornemann T, Graier WF, Malli R, Madeo F, Kratky D (2012) C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. Cell Death Dis 3:e280. https:\/\/doi.org\/10.1038\/cddis.2012.17","journal-title":"Cell Death Dis"},{"issue":"6522","key":"3_CR129","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/374549a0","volume":"374","author":"LW Tjoelker","year":"1995","unstructured":"Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, Hooper S, Le Trong H, Cousens LS, Zimmerman GA et al (1995) Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374(6522):549\u2013553. https:\/\/doi.org\/10.1038\/374549a0","journal-title":"Nature"},{"issue":"46","key":"3_CR130","doi-asserted-by":"publisher","first-page":"31,617","DOI":"10.1074\/jbc.M804750200","volume":"283","author":"U Samanta","year":"2008","unstructured":"Samanta U, Bahnson BJ (2008) Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. J Biol Chem 283(46):31,617\u201331,624. https:\/\/doi.org\/10.1074\/jbc.M804750200","journal-title":"J Biol Chem"},{"issue":"10","key":"3_CR131","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1161\/01.ATV.0000280571.28102.d4","volume":"27","author":"S Tsimikas","year":"2007","unstructured":"Tsimikas S, Tsironis LD, Tselepis AD (2007) New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler Thromb Vasc Biol 27(10):2094\u20132099. https:\/\/doi.org\/10.1161\/01.ATV.0000280571.28102.d4","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"3_CR132","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/01.mol.0000174155.61307.5f","volume":"16","author":"CH Macphee","year":"2005","unstructured":"Macphee CH, Nelson JJ, Zalewski A (2005) Lipoprotein-associated phospholipase A2 as a target of therapy. Curr Opin Lipidol 16(4):442\u2013446","journal-title":"Curr Opin Lipidol"},{"key":"3_CR133","doi-asserted-by":"crossref","first-page":"12,935","DOI":"10.1021\/bi991149u","volume":"38","author":"JH Min","year":"1999","unstructured":"Min JH, Jain MK, Wilder C, Paul L, Apitz-Castro R, Aspleaf DC, Gelb MH (1999) Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. Biochemistry 38:12,935\u201312,942 (0006-2960 (Print))","journal-title":"Biochemistry"},{"issue":"11","key":"3_CR134","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1074\/jbc.274.11.7018","volume":"274","author":"DM Stafforini","year":"1999","unstructured":"Stafforini DM, Tjoelker LW, McCormick SP, Vaitkus D, McIntyre TM, Gray PW, Young SG, Prescott SM (1999) Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. J Biol Chem 274(11):7018\u20137024","journal-title":"J Biol Chem"},{"key":"3_CR135","doi-asserted-by":"crossref","first-page":"17,099","DOI":"10.1074\/jbc.M802394200","volume":"283","author":"AA Gardner","year":"2008","unstructured":"Gardner AA, Reichert EC, Topham MK, Stafforini DM (2008) Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein. J Biol Chem 283:17,099\u201317,106 (0021-9258 (Print))","journal-title":"J Biol Chem"},{"key":"3_CR136","doi-asserted-by":"crossref","first-page":"S255","DOI":"10.1194\/jlr.R800024-JLR200","volume":"50","author":"TM McIntyre","year":"2009","unstructured":"McIntyre TM, Prescott SM, Stafforini DM (2009) The emerging roles of PAF acetylhydrolase. J Lipid Res 50:S255\u2013S259 (0022-2275 (Print))","journal-title":"J Lipid Res"},{"issue":"5","key":"3_CR137","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s11883-009-0050-6","volume":"11","author":"PA McCullough","year":"2009","unstructured":"McCullough PA (2009) Darapladib and atherosclerotic plaque: should lipoprotein-associated phospholipase A2 be a therapeutic target? Curr Atheroscler Rep 11(5):334\u2013337","journal-title":"Curr Atheroscler Rep"},{"issue":"11","key":"3_CR138","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1161\/CIRCULATIONAHA.108.771899","volume":"118","author":"PW Serruys","year":"2008","unstructured":"Serruys PW, Garcia-Garcia HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, Botker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der Steen AF, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A (2008) Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque. Circulation 118(11):1172\u20131182. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.771899","journal-title":"Circulation"},{"issue":"10","key":"3_CR139","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/nm.1870","volume":"14","author":"RL Wilensky","year":"2008","unstructured":"Wilensky RL, Shi Y, Mohler ER 3rd, Hamamdzic D, Burgert ME, Li J, Postle A, Fenning RS, Bollinger JG, Hoffman BE, Pelchovitz DJ, Yang J, Mirabile RC, Webb CL, Zhang L, Zhang P, Gelb MH, Walker MC, Zalewski A, Macphee CH (2008) Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med 14(10):1059\u20131066. https:\/\/doi.org\/10.1038\/nm.1870","journal-title":"Nat Med"},{"issue":"3","key":"3_CR140","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1074\/jbc.M708622200","volume":"283","author":"N Kono","year":"2008","unstructured":"Kono N, Inoue T, Yoshida Y, Sato H, Matsusue T, Itabe H, Niki E, Aoki J, Arai H (2008) Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. J Biol Chem 283(3):1628\u20131636. https:\/\/doi.org\/10.1074\/jbc.M708622200","journal-title":"J Biol Chem"},{"issue":"29","key":"3_CR141","doi-asserted-by":"crossref","first-page":"18,567","DOI":"10.1074\/jbc.273.29.18567","volume":"273","author":"H Manya","year":"1998","unstructured":"Manya H, Aoki J, Watanabe M, Adachi T, Asou H, Inoue Y, Arai H, Inoue K (1998) Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. J Biol Chem 273(29):18,567\u201318,572","journal-title":"J Biol Chem"},{"issue":"10","key":"3_CR142","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.bbadis.2009.06.007","volume":"1792","author":"E Kitsiouli","year":"2009","unstructured":"Kitsiouli E, Nakos G, Lekka ME (2009) Phospholipase A2 subclasses in acute respiratory distress syndrome. Biochim Biophys Acta 1792(10):941\u2013953. https:\/\/doi.org\/10.1016\/j.bbadis.2009.06.007","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3_CR143","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1074\/jbc.272.4.2542","volume":"272","author":"TS Kim","year":"1997","unstructured":"Kim TS, Sundaresh CS, Feinstein SI, Dodia C, Skach WR, Jain MK, Nagase T, Seki N, Ishikawa K, Nomura N, Fisher AB (1997) Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein. J Biol Chem 272(4):2542\u20132550","journal-title":"J Biol Chem"},{"issue":"37","key":"3_CR144","doi-asserted-by":"publisher","first-page":"28,421","DOI":"10.1074\/jbc.M005073200","volume":"275","author":"JW Chen","year":"2000","unstructured":"Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB (2000) 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem 275(37):28,421\u201328,427. https:\/\/doi.org\/10.1074\/jbc.M005073200","journal-title":"J Biol Chem"},{"issue":"5","key":"3_CR145","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1172\/JCI38061","volume":"120","author":"JP Bridges","year":"2010","unstructured":"Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM (2010) LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest 120(5):1736\u20131748. https:\/\/doi.org\/10.1172\/JCI38061","journal-title":"J Clin Invest"},{"issue":"16","key":"3_CR146","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1128\/MCB.00627-06","volume":"26","author":"M Hiraoka","year":"2006","unstructured":"Hiraoka M, Abe A, Lu Y, Yang K, Han X, Gross RW, Shayman JA (2006) Lysosomal phospholipase A2 and phospholipidosis. Mol Cell Biol 26(16):6139\u20136148. https:\/\/doi.org\/10.1128\/MCB.00627-06","journal-title":"Mol Cell Biol"},{"issue":"37","key":"3_CR147","doi-asserted-by":"publisher","first-page":"25,428","DOI":"10.1074\/jbc.M804146200","volume":"283","author":"RE Duncan","year":"2008","unstructured":"Duncan RE, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul HS (2008) Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA). J Biol Chem 283(37):25,428\u201325,436. https:\/\/doi.org\/10.1074\/jbc.M804146200","journal-title":"J Biol Chem"},{"issue":"2","key":"3_CR148","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nm.1904","volume":"15","author":"K Jaworski","year":"2009","unstructured":"Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS (2009) AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med 15(2):159\u2013168. https:\/\/doi.org\/10.1038\/nm.1904","journal-title":"Nat Med"},{"issue":"4","key":"3_CR149","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1194\/jlr.M800453-JLR200","volume":"50","author":"T Uyama","year":"2009","unstructured":"Uyama T, Morishita J, Jin XH, Okamoto Y, Tsuboi K, Ueda N (2009) The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1\/2 of the thiol hydrolase type. J Lipid Res 50(4):685\u2013693. https:\/\/doi.org\/10.1194\/jlr.M800453-JLR200","journal-title":"J Lipid Res"},{"issue":"4","key":"3_CR150","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1083\/jcb.136.4.935","volume":"136","author":"C Sers","year":"1997","unstructured":"Sers C, Emmenegger U, Husmann K, Bucher K, Andres AC, Schafer R (1997) Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. J Cell Biol 136(4):935\u2013944","journal-title":"J Cell Biol"},{"issue":"8","key":"3_CR151","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1073\/pnas.0611209104","volume":"104","author":"M Sanchez-Alavez","year":"2007","unstructured":"Sanchez-Alavez M, Klein I, Brownell SE, Tabarean IV, Davis CN, Conti B, Bartfai T (2007) Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci U S A 104(8):3009\u20133014. https:\/\/doi.org\/10.1073\/pnas.0611209104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR152","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1111\/febs.12366","volume":"280","author":"Y Matsumoto","year":"2013","unstructured":"Matsumoto Y, Mineta S, Murayama K, Sugimori D (2013) A novel phospholipase B from Streptomyces sp. NA684--purification, characterization, gene cloning, extracellular production and prediction of the catalytic residues. FEBS J 280:3780\u20133796 (1742-4658 (Electronic))","journal-title":"FEBS J"},{"issue":"Pt 2","key":"3_CR153","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1042\/BJ20040110","volume":"382","author":"CP Morgan","year":"2004","unstructured":"Morgan CP, Insall R, Haynes L, Cockcroft S (2004) Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. Biochem J 382(Pt 2):441\u2013449. https:\/\/doi.org\/10.1042\/BJ20040110","journal-title":"Biochem J"},{"issue":"24","key":"3_CR154","doi-asserted-by":"crossref","first-page":"7133","DOI":"10.1021\/bi010237n","volume":"40","author":"T Lu","year":"2001","unstructured":"Lu T, Ito M, Tchoua U, Takemori H, Okamoto M, Tojo H (2001) Identification of essential residues for catalysis of rat intestinal phospholipase B\/lipase. Biochemistry 40(24):7133\u20137139","journal-title":"Biochemistry"},{"issue":"2","key":"3_CR155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/IAI.65.2.405-411.1997","volume":"65","author":"SC Chen","year":"1997","unstructured":"Chen SC, Wright LC, Santangelo RT, Muller M, Moran VR, Kuchel PW, Sorrell TC (1997) Identification of extracellular phospholipase B, lysophospholipase, and acyltransferase produced by Cryptococcus neoformans. Infect Immun 65(2):405\u2013411","journal-title":"Infect Immun"},{"issue":"22","key":"3_CR156","doi-asserted-by":"publisher","first-page":"6717","DOI":"10.1128\/JB.183.22.6717-6720.2001","volume":"183","author":"JL Farn","year":"2001","unstructured":"Farn JL, Strugnell RA, Hoyne PA, Michalski WP, Tennent JM (2001) Molecular characterization of a secreted enzyme with phospholipase B activity from Moraxella bovis. J Bacteriol 183(22):6717\u20136720. https:\/\/doi.org\/10.1128\/JB.183.22.6717-6720.2001","journal-title":"J Bacteriol"},{"issue":"2","key":"3_CR157","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0006-291X(02)00657-5","volume":"295","author":"E Maury","year":"2002","unstructured":"Maury E, Prevost MC, Nauze M, Redoules D, Tarroux R, Charveron M, Salles JP, Perret B, Chap H, Gassama-Diagne A (2002) Human epidermis is a novel site of phospholipase B expression. Biochem Biophys Res Commun 295(2):362\u2013369","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3_CR158","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0005-2760(96)00090-2","volume":"1303","author":"C Delagebeaudeuf","year":"1996","unstructured":"Delagebeaudeuf C, Gassama A, Collet X, Nauze M, Chap H (1996) Guinea pig intestinal phospholipase B: protein expression during enterocyte maturation and effects of N-oligosaccharide removal on enzymatic activities and protein stability. Biochim Biophys Acta 1303(2):119\u2013126","journal-title":"Biochim Biophys Acta"},{"key":"3_CR159","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1749-6632.1998.tb11125.x","volume":"859","author":"C Delagebeaudeuf","year":"1998","unstructured":"Delagebeaudeuf C, Gassama-Diagne A, Nauze M, Ragab A, Li RY, Capdevielle J, Ferrara P, Fauvel J, Chap H (1998) Biochemical characterization and cloning of guinea pig intestinal phospholipase B. Ann N Y Acad Sci 859:192\u2013193","journal-title":"Ann N Y Acad Sci"},{"key":"3_CR160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fmicb.2010.00125","volume":"1","author":"JT Djordjevic","year":"2010","unstructured":"Djordjevic JT (2010) Role of phospholipases in fungal fitness, pathogenicity, and drug development - lessons from cryptococcus neoformans. Front Microbiol 1:125","journal-title":"Front Microbiol"},{"key":"3_CR161","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.plipres.2012.03.002","volume":"51","author":"FM Goni","year":"2012","unstructured":"Goni FM, Montes LR, Alonso A (2012) Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity. Prog Lipid Res 51:238\u2013266","journal-title":"Prog Lipid Res"},{"issue":"18","key":"3_CR162","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1016\/j.vaccine.2015.03.030","volume":"33","author":"V Moigne Le","year":"2015","unstructured":"Le Moigne V, Rottman M, Goulard C, Barteau B, Poncin I, Soismier N, Canaan S, Pitard B, Gaillard JL, Herrmann JL (2015) Bacterial phospholipases C as vaccine candidate antigens against cystic fibrosis respiratory pathogens: the Mycobacterium abscessus model. Vaccine 33(18):2118\u20132124. https:\/\/doi.org\/10.1016\/j.vaccine.2015.03.030","journal-title":"Vaccine"},{"issue":"1","key":"3_CR163","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/0005-2760(94)90186-4","volume":"1212","author":"JH Exton","year":"1994","unstructured":"Exton JH (1994) Phosphatidylcholine breakdown and signal transduction. Biochim Biophys Acta 1212(1):26\u201342. https:\/\/doi.org\/10.1016\/0005-2760(94)90186-4","journal-title":"Biochim Biophys Acta"},{"key":"3_CR164","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fonc.2016.00171","volume":"6","author":"F Podo","year":"2016","unstructured":"Podo F, Paris L, Cecchetti S, Spadaro F, Abalsamo L, Ramoni C, Ricci A, Pisanu ME, Sardanelli F, Canese R, Iorio E (2016) Activation of phosphatidylcholine-specific phospholipase C in breast and ovarian cancer: impact on MRS-detected choline metabolic profile and perspectives for targeted therapy. Front Oncol 6:171. https:\/\/doi.org\/10.3389\/fonc.2016.00171","journal-title":"Front Oncol"},{"key":"3_CR165","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.biochi.2013.07.004","volume":"96","author":"I Pokotylo","year":"2014","unstructured":"Pokotylo I, Kolesnikov Y, Kravets V, Zachowski A, Ruelland E (2014) Plant phosphoinositide-dependent phospholipases C: variations around a canonical theme. Biochimie 96:144\u2013157. https:\/\/doi.org\/10.1016\/j.biochi.2013.07.004","journal-title":"Biochimie"},{"issue":"1","key":"3_CR166","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.plipres.2012.09.001","volume":"52","author":"I Pokotylo","year":"2013","unstructured":"Pokotylo I, Pejchar P, Potocky M, Kocourkova D, Krckova Z, Ruelland E, Kravets V, Martinec J (2013) The plant non-specific phospholipase C gene family. Novel competitors in lipid signalling. Prog Lipid Res 52(1):62\u201379. https:\/\/doi.org\/10.1016\/j.plipres.2012.09.001","journal-title":"Prog Lipid Res"},{"issue":"6213","key":"3_CR167","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/338357a0","volume":"338","author":"E Hough","year":"1989","unstructured":"Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z (1989) High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature 338(6213):357\u2013360. https:\/\/doi.org\/10.1038\/338357a0","journal-title":"Nature"},{"issue":"Pt 6","key":"3_CR168","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1099\/mic.0.2006\/003004-0","volume":"153","author":"S Korbsrisate","year":"2007","unstructured":"Korbsrisate S, Tomaras AP, Damnin S, Ckumdee J, Srinon V, Lengwehasatit I, Vasil ML, Suparak S (2007) Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei. Microbiology 153(Pt 6):1907\u20131915. https:\/\/doi.org\/10.1099\/mic.0.2006\/003004-0","journal-title":"Microbiology"},{"key":"3_CR169","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/1471-2180-8-189","volume":"8","author":"G Rossignol","year":"2008","unstructured":"Rossignol G, Merieau A, Guerillon J, Veron W, Lesouhaitier O, Feuilloley MG, Orange N (2008) Involvement of a phospholipase C in the hemolytic activity of a clinical strain of Pseudomonas fluorescens. BMC Microbiol 8:189. https:\/\/doi.org\/10.1186\/1471-2180-8-189","journal-title":"BMC Microbiol"},{"issue":"Pt 7","key":"3_CR170","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1099\/00221287-148-7-2223","volume":"148","author":"V Aragon","year":"2002","unstructured":"Aragon V, Rossier O, Cianciotto NP (2002) Legionella pneumophila genes that encode lipase and phospholipase C activities. Microbiology 148(Pt 7):2223\u20132231. https:\/\/doi.org\/10.1099\/00221287-148-7-2223","journal-title":"Microbiology"},{"issue":"2","key":"3_CR171","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/MMBR.57.2.347-366.1993","volume":"57","author":"RW Titball","year":"1993","unstructured":"Titball RW (1993) Bacterial phospholipases C. Microbiol Rev 57(2):347\u2013366","journal-title":"Microbiol Rev"},{"issue":"20","key":"3_CR172","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1016\/j.febslet.2006.08.008","volume":"580","author":"Y Cheng","year":"2006","unstructured":"Cheng Y, Zhao Q, Liu X, Araki S, Zhang S, Miao J (2006) Phosphatidylcholine-specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells. FEBS Lett 580(20):4911\u20134915. https:\/\/doi.org\/10.1016\/j.febslet.2006.08.008","journal-title":"FEBS Lett"},{"issue":"23","key":"3_CR173","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1002\/j.1460-2075.1995.tb00274.x","volume":"14","author":"MG Cifone","year":"1995","unstructured":"Cifone MG, Roncaioli P, De Maria R, Camarda G, Santoni A, Ruberti G, Testi R (1995) Multiple pathways originate at the Fas\/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 14(23):5859\u20135868","journal-title":"EMBO J"},{"issue":"2","key":"3_CR174","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.yexcr.2004.05.037","volume":"299","author":"C Ramoni","year":"2004","unstructured":"Ramoni C, Spadaro F, Barletta B, Dupuis ML, Podo F (2004) Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts. Exp Cell Res 299(2):370\u2013382. https:\/\/doi.org\/10.1016\/j.yexcr.2004.05.037","journal-title":"Exp Cell Res"},{"issue":"6","key":"3_CR175","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1002\/jcb.21139","volume":"100","author":"N Wang","year":"2007","unstructured":"Wang N, Xie K, Huo S, Zhao J, Zhang S, Miao J (2007) Suppressing phosphatidylcholine-specific phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells. J Cell Biochem 100(6):1548\u20131557. https:\/\/doi.org\/10.1002\/jcb.21139","journal-title":"J Cell Biochem"},{"issue":"1","key":"3_CR176","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1189\/jlb.3RU0316-148RR","volume":"101","author":"S Cecchetti","year":"2017","unstructured":"Cecchetti S, Spadaro F, Gessani S, Podo F, Fantuzzi L (2017) Phospholipases: at the crossroads of the immune system and the pathogenesis of HIV-1 infection. J Leukoc Biol 101(1):53\u201375. https:\/\/doi.org\/10.1189\/jlb.3RU0316-148RR","journal-title":"J Leukoc Biol"},{"issue":"2","key":"3_CR177","doi-asserted-by":"publisher","first-page":"R50","DOI":"10.1186\/bcr3151","volume":"14","author":"L Abalsamo","year":"2012","unstructured":"Abalsamo L, Spadaro F, Bozzuto G, Paris L, Cecchetti S, Lugini L, Iorio E, Molinari A, Ramoni C, Podo F (2012) Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells. Breast Cancer Res 14(2):R50. https:\/\/doi.org\/10.1186\/bcr3151","journal-title":"Breast Cancer Res"},{"issue":"5","key":"3_CR178","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1158\/0008-5472.CAN-09-3833","volume":"70","author":"E Iorio","year":"2010","unstructured":"Iorio E, Ricci A, Bagnoli M, Pisanu ME, Castellano G, Di Vito M, Venturini E, Glunde K, Bhujwalla ZM, Mezzanzanica D, Canevari S, Podo F (2010) Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res 70(5):2126\u20132135. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-3833","journal-title":"Cancer Res"},{"issue":"3","key":"3_CR179","doi-asserted-by":"publisher","first-page":"R27","DOI":"10.1186\/bcr2575","volume":"12","author":"L Paris","year":"2010","unstructured":"Paris L, Cecchetti S, Spadaro F, Abalsamo L, Lugini L, Pisanu ME, Iorio E, Natali PG, Ramoni C, Podo F (2010) Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells. Breast Cancer Res 12(3):R27. https:\/\/doi.org\/10.1186\/bcr2575","journal-title":"Breast Cancer Res"},{"issue":"16","key":"3_CR180","doi-asserted-by":"publisher","first-page":"6541","DOI":"10.1158\/0008-5472.CAN-07-6763","volume":"68","author":"F Spadaro","year":"2008","unstructured":"Spadaro F, Ramoni C, Mezzanzanica D, Miotti S, Alberti P, Cecchetti S, Iorio E, Dolo V, Canevari S, Podo F (2008) Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells. Cancer Res 68(16):6541\u20136549. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-6763","journal-title":"Cancer Res"},{"issue":"12","key":"3_CR181","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1016\/S0021-9258(17)39606-0","volume":"260","author":"RA Wolf","year":"1985","unstructured":"Wolf RA, Gross RW (1985) Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium. J Biol Chem 260(12):7295\u20137303","journal-title":"J Biol Chem"},{"issue":"16","key":"3_CR182","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1016\/S0021-9258(17)38426-0","volume":"261","author":"RG Sheikhnejad","year":"1986","unstructured":"Sheikhnejad RG, Srivastava PN (1986) Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma. J Biol Chem 261(16):7544\u20137549","journal-title":"J Biol Chem"},{"issue":"3","key":"3_CR183","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.bbamem.2009.12.008","volume":"1798","author":"MV Mateos","year":"2010","unstructured":"Mateos MV, Salvador GA, Giusto NM (2010) Selective localization of phosphatidylcholine-derived signaling in detergent-resistant membranes from synaptic endings. Biochim Biophys Acta 1798(3):624\u2013636. https:\/\/doi.org\/10.1016\/j.bbamem.2009.12.008","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3_CR184","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s11064-011-0659-z","volume":"37","author":"RM Adibhatla","year":"2012","unstructured":"Adibhatla RM, Hatcher JF, Gusain A (2012) Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem Res 37(4):671\u2013679. https:\/\/doi.org\/10.1007\/s11064-011-0659-z","journal-title":"Neurochem Res"},{"issue":"3","key":"3_CR185","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/mp\/ssq005","volume":"3","author":"R Wimalasekera","year":"2010","unstructured":"Wimalasekera R, Pejchar P, Holk A, Martinec J, Scherer GF (2010) Plant phosphatidylcholine-hydrolyzing phospholipases C NPC3 and NPC4 with roles in root development and brassinolide signaling in Arabidopsis thaliana. Mol Plant 3(3):610\u2013625. https:\/\/doi.org\/10.1093\/mp\/ssq005","journal-title":"Mol Plant"},{"issue":"11","key":"3_CR186","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1093\/jxb\/err039","volume":"62","author":"D Kocourkova","year":"2011","unstructured":"Kocourkova D, Krckova Z, Pejchar P, Veselkova S, Valentova O, Wimalasekera R, Scherer GF, Martinec J (2011) The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress. J Exp Bot 62(11):3753\u20133763. https:\/\/doi.org\/10.1093\/jxb\/err039","journal-title":"J Exp Bot"},{"issue":"1","key":"3_CR187","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1469-8137.2010.03349.x","volume":"188","author":"P Pejchar","year":"2010","unstructured":"Pejchar P, Potocky M, Novotna Z, Veselkova S, Kocourkova D, Valentova O, Schwarzerova K, Martinec J (2010) Aluminium ions inhibit the formation of diacylglycerol generated by phosphatidylcholine-hydrolysing phospholipase C in tobacco cells. New Phytol 188(1):150\u2013160. https:\/\/doi.org\/10.1111\/j.1469-8137.2010.03349.x","journal-title":"New Phytol"},{"issue":"8","key":"3_CR188","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1105\/tpc.109.071720","volume":"22","author":"C Peters","year":"2010","unstructured":"Peters C, Li M, Narasimhan R, Roth M, Welti R, Wang X (2010) Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis. Plant Cell 22(8):2642\u20132659. https:\/\/doi.org\/10.1105\/tpc.109.071720","journal-title":"Plant Cell"},{"issue":"40","key":"3_CR189","doi-asserted-by":"publisher","first-page":"30,289","DOI":"10.1074\/jbc.M606391200","volume":"281","author":"RL Felts","year":"2006","unstructured":"Felts RL, Reilly TJ, Tanner JJ (2006) Structure of Francisella tularensis AcpA: prototype of a unique superfamily of acid phosphatases and phospholipases C. J Biol Chem 281(40):30,289\u201330,298. https:\/\/doi.org\/10.1074\/jbc.M606391200","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR190","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1365-313X.2008.03582.x","volume":"56","author":"N Gaude","year":"2008","unstructured":"Gaude N, Nakamura Y, Scheible WR, Ohta H, Dormann P (2008) Phospholipase C5 (NPC5) is involved in galactolipid accumulation during phosphate limitation in leaves of Arabidopsis. Plant J 56(1):28\u201339. https:\/\/doi.org\/10.1111\/j.1365-313X.2008.03582.x","journal-title":"Plant J"},{"issue":"32","key":"3_CR191","doi-asserted-by":"publisher","first-page":"29,128","DOI":"10.1074\/jbc.M503817200","volume":"280","author":"M Nakahara","year":"2005","unstructured":"Nakahara M, Shimozawa M, Nakamura Y, Irino Y, Morita M, Kudo Y, Fukami K (2005) A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. J Biol Chem 280(32):29,128\u201329,134. https:\/\/doi.org\/10.1074\/jbc.M503817200","journal-title":"J Biol Chem"},{"issue":"4","key":"3_CR192","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bbalip.2009.12.005","volume":"1801","author":"VS Reddy","year":"2010","unstructured":"Reddy VS, Rao DK, Rajasekharan R (2010) Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana. Biochim Biophys Acta 1801(4):455\u2013461. https:\/\/doi.org\/10.1016\/j.bbalip.2009.12.005","journal-title":"Biochim Biophys Acta"},{"key":"3_CR193","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-physiol-030212-183750","volume":"75","author":"G Kadamur","year":"2013","unstructured":"Kadamur G, Ross EM (2013) Mammalian phospholipase C. Annu Rev Physiol 75:127\u2013154. https:\/\/doi.org\/10.1146\/annurev-physiol-030212-183750","journal-title":"Annu Rev Physiol"},{"issue":"36","key":"3_CR194","doi-asserted-by":"publisher","first-page":"12,927","DOI":"10.1073\/pnas.0501725102","volume":"102","author":"Z Wei","year":"2005","unstructured":"Wei Z, Zenewicz LA, Goldfine H (2005) Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors. Proc Natl Acad Sci U S A 102(36):12,927\u201312,931. https:\/\/doi.org\/10.1073\/pnas.0501725102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR195","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jbior.2014.10.004","volume":"57","author":"MY Follo","year":"2015","unstructured":"Follo MY, Manzoli L, Poli A, McCubrey JA, Cocco L (2015) PLC and PI3K\/Akt\/mTOR signalling in disease and cancer. Adv Biol Regul 57:10\u201316. https:\/\/doi.org\/10.1016\/j.jbior.2014.10.004","journal-title":"Adv Biol Regul"},{"issue":"2-3","key":"3_CR196","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1388-1981(99)00150-X","volume":"1441","author":"RL Williams","year":"1999","unstructured":"Williams RL (1999) Mammalian phosphoinositide-specific phospholipase C. Biochim Biophys Acta 1441(2-3):255\u2013267","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3_CR197","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/jb\/mvw094","volume":"161","author":"Y Nakamura","year":"2017","unstructured":"Nakamura Y, Fukami K (2017) Regulation and physiological functions of mammalian phospholipase C. J Biochem 161(4):315\u2013321. https:\/\/doi.org\/10.1093\/jb\/mvw094","journal-title":"J Biochem"},{"issue":"2","key":"3_CR198","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.tibs.2010.08.003","volume":"36","author":"TD Bunney","year":"2011","unstructured":"Bunney TD, Katan M (2011) PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem Sci 36(2):88\u201396. https:\/\/doi.org\/10.1016\/j.tibs.2010.08.003","journal-title":"Trends Biochem Sci"},{"issue":"6","key":"3_CR199","doi-asserted-by":"crossref","first-page":"415","DOI":"10.5483\/BMBRep.2008.41.6.415","volume":"41","author":"PG Suh","year":"2008","unstructured":"Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep 41(6):415\u2013434","journal-title":"BMB Rep"},{"key":"3_CR200","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/380595a0","volume":"380","author":"L-O Essen","year":"1996","unstructured":"Essen L-O, Perisic O, Cheung R, Katan M, Williams RL (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase C\u03b4. Nature 380:595\u2013602","journal-title":"Nature"},{"key":"3_CR201","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1021\/bi962466t","volume":"36","author":"L-O Essen","year":"1997","unstructured":"Essen L-O, Perisic O, Lynch DE, Katan M, Williams RL (1997) A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C\u03b41. Biochemistry 36:2753\u20132762","journal-title":"Biochemistry"},{"issue":"4","key":"3_CR202","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1152\/physrev.2000.80.4.1291","volume":"80","author":"MJ Rebecchi","year":"2000","unstructured":"Rebecchi MJ, Pentyala SN (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 80(4):1291\u20131335","journal-title":"Physiol Rev"},{"issue":"12","key":"3_CR203","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/pro.5560051201","volume":"5","author":"EA Nalefski","year":"1996","unstructured":"Nalefski EA, Falke JJ (1996) The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci 5(12):2375\u20132390","journal-title":"Protein Sci"},{"issue":"5","key":"3_CR204","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/pro.5560050513","volume":"5","author":"CP Ponting","year":"1996","unstructured":"Ponting CP, Kerr ID (1996) A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci 5(5):914\u2013922. https:\/\/doi.org\/10.1002\/pro.5560050513","journal-title":"Protein Sci"},{"issue":"1","key":"3_CR205","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/pro.5560050120","volume":"5","author":"CP Ponting","year":"1996","unstructured":"Ponting CP, Parker PJ (1996) Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. Protein Sci 5(1):162\u2013166","journal-title":"Protein Sci"},{"issue":"2-3","key":"3_CR206","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(01)02453-X","volume":"497","author":"L Otterhag","year":"2001","unstructured":"Otterhag L, Sommarin M, Pical C (2001) N-terminal EF-hand-like domain is required for phosphoinositide-specific phospholipase C activity in Arabidopsis thaliana. FEBS Lett 497(2-3):165\u2013170","journal-title":"FEBS Lett"},{"issue":"6427","key":"3_CR207","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/363309b0","volume":"363","author":"RJ Haslam","year":"1993","unstructured":"Haslam RJ, Koide HB, Hemmings BA (1993) Pleckstrin domain homology. Nature 363(6427):309\u2013310. https:\/\/doi.org\/10.1038\/363309b0","journal-title":"Nature"},{"issue":"4","key":"3_CR208","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0092-8674(93)90244-K","volume":"73","author":"BJ Mayer","year":"1993","unstructured":"Mayer BJ, Ren R, Clark KL, Baltimore D (1993) A putative modular domain present in diverse signaling proteins. Cell 73(4):629\u2013630","journal-title":"Cell"},{"issue":"6","key":"3_CR209","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(95)90219-8","volume":"83","author":"KM Ferguson","year":"1995","unstructured":"Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB (1995) Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83(6):1037\u20131046","journal-title":"Cell"},{"key":"3_CR210","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.biochem.66.1.475","volume":"66","author":"WD Singer","year":"1997","unstructured":"Singer WD, Brown HA, Sternweis PC (1997) Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Annu Rev Biochem 66:475\u2013509","journal-title":"Annu Rev Biochem"},{"key":"3_CR211","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1146\/annurev.biochem.70.1.281","volume":"70","author":"SG Rhee","year":"2001","unstructured":"Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70:281\u2013312. https:\/\/doi.org\/10.1146\/annurev.biochem.70.1.281","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"3_CR212","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1006\/bbrc.1998.8314","volume":"244","author":"P Sozzani","year":"1998","unstructured":"Sozzani P, Hasan L, Seguelas MH, Caput D, Ferrara P, Pipy B, Cambon C (1998) IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production. Biochem Biophys Res Commun 244(3):665\u2013670. https:\/\/doi.org\/10.1006\/bbrc.1998.8314","journal-title":"Biochem Biophys Res Commun"},{"issue":"13","key":"3_CR213","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1074\/jbc.273.13.7703","volume":"273","author":"RC Venema","year":"1998","unstructured":"Venema RC, Ju H, Venema VJ, Schieffer B, Harp JB, Ling BN, Eaton DC, Marrero MB (1998) Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor. J Biol Chem 273(13):7703\u20137708","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR214","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/bbrc.1998.8574","volume":"246","author":"VJ Venema","year":"1998","unstructured":"Venema VJ, Ju H, Sun J, Eaton DC, Marrero MB, Venema RC (1998) Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2 receptor association of phospholipase C gamma 1 in vascular endothelial cells. Biochem Biophys Res Commun 246(1):70\u201375. https:\/\/doi.org\/10.1006\/bbrc.1998.8574","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"3_CR215","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.cellsig.2012.01.009","volume":"24","author":"AV Smrcka","year":"2012","unstructured":"Smrcka AV, Brown JH, Holz GG (2012) Role of phospholipase C\u03b5 in physiological phosphoinositide signaling networks. Cell Signal 24(6):1333\u20131343. https:\/\/doi.org\/10.1016\/j.cellsig.2012.01.009","journal-title":"Cell Signal"},{"issue":"6","key":"3_CR216","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1530\/rep.1.00484","volume":"128","author":"NT Rogers","year":"2004","unstructured":"Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K (2004) Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes. Reproduction 128(6):697\u2013702. https:\/\/doi.org\/10.1530\/rep.1.00484","journal-title":"Reproduction"},{"issue":"4","key":"3_CR217","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1530\/rep.1.00169","volume":"127","author":"K Swann","year":"2004","unstructured":"Swann K, Larman MG, Saunders CM, Lai FA (2004) The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCzeta. Reproduction 127(4):431\u2013439. https:\/\/doi.org\/10.1530\/rep.1.00169","journal-title":"Reproduction"},{"issue":"Pt 3","key":"3_CR218","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1042\/BJ20050839","volume":"391","author":"Y Zhou","year":"2005","unstructured":"Zhou Y, Wing MR, Sondek J, Harden TK (2005) Molecular cloning and characterization of PLC-eta2. Biochem J 391(Pt 3):667\u2013676. https:\/\/doi.org\/10.1042\/BJ20050839","journal-title":"Biochem J"},{"issue":"3","key":"3_CR219","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0021-9258(18)96298-8","volume":"242","author":"SF Yang","year":"1967","unstructured":"Yang SF, Freer S, Benson AA (1967) Transphosphatidylation by phospholipase D. J Biol Chem 242(3):477\u2013484","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR220","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9258(17)35110-4","volume":"168","author":"DJ Hanahan","year":"1947","unstructured":"Hanahan DJ, Chaikoff IL (1947) The phosphorus-containing lipides of the carrot. J Biol Chem 168(1):233\u2013240","journal-title":"J Biol Chem"},{"issue":"1","key":"3_CR221","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/bj1020205","volume":"102","author":"RM Dawson","year":"1967","unstructured":"Dawson RM (1967) The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D. Biochem J 102(1):205\u2013210","journal-title":"Biochem J"},{"issue":"2","key":"3_CR222","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1006\/abbi.1993.1541","volume":"306","author":"X Wang","year":"1993","unstructured":"Wang X, Dyer JH, Zheng L (1993) Purification and immunological analysis of phospholipase D from castor bean endosperm. Arch Biochem Biophys 306(2):486\u2013494","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"3_CR223","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4165(93)90088-P","volume":"1158","author":"A Abousalham","year":"1993","unstructured":"Abousalham A, Riviere M, Teissere M, Verger R (1993) Improved purification and biochemical characterization of phospholipase D from cabbage. Biochim Biophys Acta 1158(1):1\u20137","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"3_CR224","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/oxfordjournals.pcp.a078871","volume":"36","author":"A Abousalham","year":"1995","unstructured":"Abousalham A, Teissere M, Gardies AM, Verger R, Noat G (1995) Phospholipase D from soybean (Glycine max L.) suspension-cultured cells: purification, structural and enzymatic properties. Plant Cell Physiol 36(6):989\u2013996","journal-title":"Plant Cell Physiol"},{"issue":"32","key":"3_CR225","doi-asserted-by":"crossref","first-page":"20,312","DOI":"10.1016\/S0021-9258(17)31993-2","volume":"269","author":"X Wang","year":"1994","unstructured":"Wang X, Xu L, Zheng L (1994) Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. J Biol Chem 269(32):20,312\u201320,317","journal-title":"J Biol Chem"},{"issue":"10","key":"3_CR226","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1021\/cr200296t","volume":"111","author":"PE Selvy","year":"2011","unstructured":"Selvy PE, Lavieri RR, Lindsley CW, Brown HA (2011) Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev 111(10):6064\u20136119. https:\/\/doi.org\/10.1021\/cr200296t","journal-title":"Chem Rev"},{"issue":"50","key":"3_CR227","doi-asserted-by":"crossref","first-page":"29,640","DOI":"10.1074\/jbc.270.50.29640","volume":"270","author":"SM Hammond","year":"1995","unstructured":"Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA (1995) Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem 270(50):29,640\u201329,643","journal-title":"J Biol Chem"},{"issue":"44","key":"3_CR228","doi-asserted-by":"publisher","first-page":"7766","DOI":"10.1021\/bi401178y","volume":"52","author":"YV Shulga","year":"2013","unstructured":"Shulga YV, Loukov D, Ivanova PT, Milne SB, Myers DS, Hatch GM, Umeh G, Jalan D, Fullerton MD, Steinberg GR, Topham MK, Brown HA, Epand RM (2013) Diacylglycerol kinase delta promotes lipogenesis. Biochemistry 52(44):7766\u20137776. https:\/\/doi.org\/10.1021\/bi401178y","journal-title":"Biochemistry"},{"issue":"9","key":"3_CR229","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1194\/jlr.M008748","volume":"51","author":"AY Andreyev","year":"2010","unstructured":"Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA (2010) Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res 51(9):2785\u20132797. https:\/\/doi.org\/10.1194\/jlr.M008748","journal-title":"J Lipid Res"},{"issue":"6","key":"3_CR230","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/bi0478502","volume":"44","author":"EE Kooijman","year":"2005","unstructured":"Kooijman EE, Chupin V, Fuller NL, Kozlov MM, de Kruijff B, Burger KN, Rand PR (2005) Spontaneous curvature of phosphatidic acid and lysophosphatidic acid. Biochemistry 44(6):2097\u20132102. https:\/\/doi.org\/10.1021\/bi0478502","journal-title":"Biochemistry"},{"issue":"4","key":"3_CR231","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1124\/pr.114.009217","volume":"66","author":"RC Bruntz","year":"2014","unstructured":"Bruntz RC, Lindsley CW, Brown HA (2014) Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev 66(4):1033\u20131079. https:\/\/doi.org\/10.1124\/pr.114.009217","journal-title":"Pharmacol Rev"},{"issue":"9","key":"3_CR232","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.bbalip.2009.04.001","volume":"1791","author":"EE Kooijman","year":"2009","unstructured":"Kooijman EE, Burger KN (2009) Biophysics and function of phosphatidic acid: a molecular perspective. Biochim Biophys Acta 1791(9):881\u2013888. https:\/\/doi.org\/10.1016\/j.bbalip.2009.04.001","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"3_CR233","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1161\/ATVBAHA.113.302030","volume":"33","author":"D Stegner","year":"2013","unstructured":"Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B (2013) Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke\u2014brief report. Arterioscler Thromb Vasc Biol 33(9):2212\u20132217. https:\/\/doi.org\/10.1161\/ATVBAHA.113.302030","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"14","key":"3_CR234","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1128\/MCB.01519-12","volume":"33","author":"DW Kang","year":"2013","unstructured":"Kang DW, Park MK, Oh HJ, Lee DG, Park SH, Choi KY, Cho ML, Min do S (2013) Phospholipase D1 has a pivotal role in interleukin-1beta-driven chronic autoimmune arthritis through regulation of NF-kappaB, hypoxia-inducible factor 1alpha, and FoxO3a. Mol Cell Biol 33(14):2760\u20132772. https:\/\/doi.org\/10.1128\/MCB.01519-12","journal-title":"Mol Cell Biol"},{"issue":"8","key":"3_CR235","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.bbalip.2010.04.004","volume":"1801","author":"TG Oliveira","year":"2010","unstructured":"Oliveira TG, Di Paolo G (2010) Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta 1801(8):799\u2013805. https:\/\/doi.org\/10.1016\/j.bbalip.2010.04.004","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"3_CR236","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archsurg.2007.73","volume":"143","author":"M Bluth","year":"2008","unstructured":"Bluth M, Lin YY, Zhang H, Viterbo D, Zenilman M (2008) Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis. Arch Surg 143(3):227\u2013233.; discussion 233-224. https:\/\/doi.org\/10.1001\/archsurg.2007.73","journal-title":"Arch Surg"},{"issue":"5","key":"3_CR237","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010506","volume":"5","author":"S Sethu","year":"2010","unstructured":"Sethu S, Pushparaj PN, Melendez AJ (2010) Phospholipase D1 mediates TNFalpha-induced inflammation in a murine model of TNFalpha-induced peritonitis. PLoS One 5(5):e10506. https:\/\/doi.org\/10.1371\/journal.pone.0010506","journal-title":"PLoS One"},{"issue":"3","key":"3_CR238","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(sici)1098-1136(200005)30:3<311::aid-glia10>3.0.co;2-k","volume":"30","author":"M-Y Lee","year":"2000","unstructured":"Lee M-Y, Kim SY, Min DS, Choi Y-S, Shin S-L, Chun M-H, Lee SB, Kim M-S, Jo Y-H (2000) Upregulation of phospholipase D in astrocytes in response to transient forebrain ischemia. Glia 30(3):311\u2013317. https:\/\/doi.org\/10.1002\/(sici)1098-1136(200005)30:3<311::aid-glia10>3.0.co;2-k","journal-title":"Glia"},{"issue":"49","key":"3_CR239","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1038\/onc.2013.207","volume":"32","author":"KM Henkels","year":"2013","unstructured":"Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J (2013) Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model. Oncogene 32(49):5551\u20135562. https:\/\/doi.org\/10.1038\/onc.2013.207","journal-title":"Oncogene"},{"issue":"1","key":"3_CR240","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/bbrc.2000.3719","volume":"278","author":"Y Zhao","year":"2000","unstructured":"Zhao Y, Ehara H, Akao Y, Shamoto M, Nakagawa Y, Banno Y, Deguchi T, Ohishi N, Yagi K, Nozawa Y (2000) Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem Biophys Res Commun 278(1):140\u2013143. https:\/\/doi.org\/10.1006\/bbrc.2000.3719","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3_CR241","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/carcin\/bgn287","volume":"30","author":"MH Park","year":"2009","unstructured":"Park MH, Ahn BH, Hong YK, Min do S (2009) Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A\/NF-kappaB\/Sp1-mediated signaling pathways. Carcinogenesis 30(2):356\u2013365. https:\/\/doi.org\/10.1093\/carcin\/bgn287","journal-title":"Carcinogenesis"},{"issue":"5","key":"3_CR242","first-page":"1329","volume":"18","author":"M Saito","year":"2007","unstructured":"Saito M, Iwadate M, Higashimoto M, Ono K, Takebayashi Y, Takenoshita S (2007) Expression of phospholipase D2 in human colorectal carcinoma. Oncol Rep 18(5):1329\u20131334","journal-title":"Oncol Rep"},{"issue":"5","key":"3_CR243","first-page":"2795","volume":"35","author":"YH Kang","year":"2015","unstructured":"Kang YH, Kim D, Jin EJ (2015) Down-regulation of phospholipase D stimulates death of lung cancer cells involving up-regulation of the long ncRNA ANRIL. Anticancer Res 35(5):2795\u20132803","journal-title":"Anticancer Res"},{"issue":"12","key":"3_CR244","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1194\/jlr.R059220","volume":"56","author":"RK Nelson","year":"2015","unstructured":"Nelson RK, Frohman MA (2015) Physiological and pathophysiological roles for phospholipase D. J Lipid Res 56(12):2229\u20132237. https:\/\/doi.org\/10.1194\/jlr.R059220","journal-title":"J Lipid Res"},{"issue":"249","key":"3_CR245","doi-asserted-by":"publisher","first-page":"ra79","DOI":"10.1126\/scisignal.2003257","volume":"5","author":"Q Chen","year":"2012","unstructured":"Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, van der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA (2012) Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal 5(249):ra79. https:\/\/doi.org\/10.1126\/scisignal.2003257","journal-title":"Sci Signal"},{"issue":"8","key":"3_CR246","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1002\/eji.201344107","volume":"44","author":"K Gobel","year":"2014","unstructured":"Gobel K, Schuhmann MK, Pankratz S, Stegner D, Herrmann AM, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth SG (2014) Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol 44(8):2295\u20132305. https:\/\/doi.org\/10.1002\/eji.201344107","journal-title":"Eur J Immunol"},{"issue":"6","key":"3_CR247","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1074\/jbc.274.6.3659","volume":"274","author":"TC Sung","year":"1999","unstructured":"Sung TC, Zhang Y, Morris AJ, Frohman MA (1999) Structural analysis of human phospholipase D1. J Biol Chem 274(6):3659\u20133666","journal-title":"J Biol Chem"},{"issue":"11","key":"3_CR248","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ncb1487","volume":"8","author":"SY Choi","year":"2006","unstructured":"Choi SY, Huang P, Jenkins GM, Chan DC, Schiller J, Frohman MA (2006) A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat Cell Biol 8(11):1255\u20131262. https:\/\/doi.org\/10.1038\/ncb1487","journal-title":"Nat Cell Biol"},{"key":"3_CR249","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/bs.mie.2016.09.041","volume":"583","author":"F Philip","year":"2017","unstructured":"Philip F, Ha EE, Seeliger MA, Frohman MA (2017) Measuring phospholipase D enzymatic activity through biochemical and imaging methods. Methods Enzymol 583:309\u2013325. https:\/\/doi.org\/10.1016\/bs.mie.2016.09.041","journal-title":"Methods Enzymol"},{"issue":"2","key":"3_CR250","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0163-7827(00)00002-3","volume":"39","author":"X Wang","year":"2000","unstructured":"Wang X (2000) Multiple forms of phospholipase D in plants: the gene family, catalytic and regulatory properties, and cellular functions. Prog Lipid Res 39(2):109\u2013149","journal-title":"Prog Lipid Res"},{"issue":"2","key":"3_CR251","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1104\/pp.113.223503","volume":"163","author":"F Pinosa","year":"2013","unstructured":"Pinosa F, Buhot N, Kwaaitaal M, Fahlberg P, Thordal-Christensen H, Ellerstrom M, Andersson MX (2013) Arabidopsis phospholipase delta is involved in basal defense and nonhost resistance to powdery mildew fungi. Plant Physiol 163(2):896\u2013906. https:\/\/doi.org\/10.1104\/pp.113.223503","journal-title":"Plant Physiol"},{"key":"3_CR252","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/1476-511X-10-196","volume":"10","author":"S Abdelkafi","year":"2011","unstructured":"Abdelkafi S, Abousalham A (2011) The substrate specificities of sunflower and soybean phospholipases D using transphosphatidylation reaction. Lipids Health Dis 10:196. https:\/\/doi.org\/10.1186\/1476-511X-10-196","journal-title":"Lipids Health Dis"},{"issue":"1","key":"3_CR253","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1021\/acs.analchem.5b02332","volume":"88","author":"R Rahier","year":"2016","unstructured":"Rahier R, Noiriel A, Abousalham A (2016) Development of a direct and continuous phospholipase D assay based on the chelation-enhanced fluorescence property of 8-hydroxyquinoline. Anal Chem 88(1):666\u2013674. https:\/\/doi.org\/10.1021\/acs.analchem.5b02332","journal-title":"Anal Chem"},{"issue":"12","key":"3_CR254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028086","volume":"6","author":"J Zhao","year":"2011","unstructured":"Zhao J, Wang C, Bedair M, Welti R, Sumner LW, Baxter I, Wang X (2011) Suppression of phospholipase Dgammas confers increased aluminum resistance in Arabidopsis thaliana. PLoS One 6(12):e28086. https:\/\/doi.org\/10.1371\/journal.pone.0028086","journal-title":"PLoS One"},{"issue":"3","key":"3_CR255","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1104\/pp.010444","volume":"127","author":"C Wang","year":"2001","unstructured":"Wang C, Wang X (2001) A novel phospholipase D of Arabidopsis that is activated by oleic acid and associated with the plasma membrane. Plant Physiol 127(3):1102\u20131112","journal-title":"Plant Physiol"},{"issue":"3","key":"3_CR256","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1365-313X.2009.03788.x","volume":"58","author":"Y Hong","year":"2009","unstructured":"Hong Y, Devaiah SP, Bahn SC, Thamasandra BN, Li M, Welti R, Wang X (2009) Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth. Plant J 58(3):376\u2013387. https:\/\/doi.org\/10.1111\/j.1365-313X.2009.03788.x","journal-title":"Plant J"},{"issue":"4","key":"3_CR257","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/genetics\/160.4.1353","volume":"160","author":"SA Rudge","year":"2002","unstructured":"Rudge SA, Zhou C, Engebrecht J (2002) Differential regulation of Saccharomyces cerevisiae phospholipase D in sporulation and Sec14-independent secretion. Genetics 160(4):1353\u20131361","journal-title":"Genetics"},{"issue":"6","key":"3_CR258","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0969-2126(00)00150-7","volume":"8","author":"I Leiros","year":"2000","unstructured":"Leiros I, Secundo F, Zambonelli C, Servi S, Hough E (2000) The first crystal structure of a phospholipase D. Structure 8(6):655\u2013667","journal-title":"Structure"},{"issue":"4","key":"3_CR259","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.jmb.2004.04.003","volume":"339","author":"I Leiros","year":"2004","unstructured":"Leiros I, McSweeney S, Hough E (2004) The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol 339(4):805\u2013820. https:\/\/doi.org\/10.1016\/j.jmb.2004.04.003","journal-title":"J Mol Biol"},{"issue":"3","key":"3_CR260","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/6716","volume":"6","author":"JA Stuckey","year":"1999","unstructured":"Stuckey JA, Dixon JE (1999) Crystal structure of a phospholipase D family member. Nat Struct Biol 6(3):278\u2013284. https:\/\/doi.org\/10.1038\/6716","journal-title":"Nat Struct Biol"},{"issue":"37","key":"3_CR261","doi-asserted-by":"publisher","first-page":"13,764","DOI":"10.1021\/ja4042753","volume":"135","author":"NJ DeYonker","year":"2013","unstructured":"DeYonker NJ, Webster CE (2013) Phosphoryl transfers of the phospholipase D superfamily: a quantum mechanical theoretical study. J Am Chem Soc 135(37):13,764\u201313,774. https:\/\/doi.org\/10.1021\/ja4042753","journal-title":"J Am Chem Soc"},{"issue":"52","key":"3_CR262","doi-asserted-by":"crossref","first-page":"34,679","DOI":"10.1074\/jbc.273.52.34679","volume":"273","author":"Z Xie","year":"1998","unstructured":"Xie Z, Ho WT, Exton JH (1998) Association of N- and C-terminal domains of phospholipase D is required for catalytic activity. J Biol Chem 273(52):34,679\u201334,682","journal-title":"J Biol Chem"},{"issue":"32","key":"3_CR263","doi-asserted-by":"publisher","first-page":"24,962","DOI":"10.1074\/jbc.M909745199","volume":"275","author":"Z Xie","year":"2000","unstructured":"Xie Z, Ho WT, Exton JH (2000) Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser\/Thr phosphorylation of the enzyme. J Biol Chem 275(32):24,962\u201324,969. https:\/\/doi.org\/10.1074\/jbc.M909745199","journal-title":"J Biol Chem"},{"issue":"15","key":"3_CR264","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1093\/emboj\/16.15.4519","volume":"16","author":"TC Sung","year":"1997","unstructured":"Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, Frohman MA (1997) Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J 16(15):4519\u20134530. https:\/\/doi.org\/10.1093\/emboj\/16.15.4519","journal-title":"EMBO J"},{"issue":"11","key":"3_CR265","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1002\/pmic.200800445","volume":"9","author":"IF Chang","year":"2009","unstructured":"Chang IF, Curran A, Woolsey R, Quilici D, Cushman JC, Mittler R, Harmon A, Harper JF (2009) Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Proteomics 9(11):2967\u20132985. https:\/\/doi.org\/10.1002\/pmic.200800445","journal-title":"Proteomics"},{"issue":"1","key":"3_CR266","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.febslet.2010.11.025","volume":"585","author":"R Shin","year":"2011","unstructured":"Shin R, Jez JM, Basra A, Zhang B, Schachtman DP (2011) 14-3-3 proteins fine-tune plant nutrient metabolism. FEBS Lett 585(1):143\u2013147. https:\/\/doi.org\/10.1016\/j.febslet.2010.11.025","journal-title":"FEBS Lett"},{"key":"3_CR267","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0079-6603(04)79003-0","volume":"79","author":"C Zambonelli","year":"2005","unstructured":"Zambonelli C, Roberts MF (2005) Non-HKD phospholipase D enzymes: new players in phosphatidic acid signaling? Prog Nucleic Acid Res Mol Biol 79:133\u2013181. https:\/\/doi.org\/10.1016\/s0079-6603(04)79003-0","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"issue":"52","key":"3_CR268","doi-asserted-by":"publisher","first-page":"52,282","DOI":"10.1074\/jbc.M310252200","volume":"278","author":"C Zambonelli","year":"2003","unstructured":"Zambonelli C, Casali M, Roberts MF (2003) Mutagenesis of putative catalytic and regulatory residues of Streptomyces chromofuscus phospholipase D differentially modifies phosphatase and phosphodiesterase activities. J Biol Chem 278(52):52,282\u201352,289. https:\/\/doi.org\/10.1074\/jbc.M310252200","journal-title":"J Biol Chem"},{"issue":"4","key":"3_CR269","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153090","volume":"11","author":"MA Correa","year":"2016","unstructured":"Correa MA, Okamoto CK, Goncalves-de-Andrade RM, van den Berg CW, Tambourgi DV (2016) Sphingomyelinase D from loxosceles laeta venom induces the expression of MMP7 in human keratinocytes: contribution to dermonecrosis. PLoS One 11(4):e0153090. https:\/\/doi.org\/10.1371\/journal.pone.0153090","journal-title":"PLoS One"},{"key":"3_CR270","doi-asserted-by":"publisher","unstructured":"Rojas JM, Aran-Sekul T, Cortes E, Jaldin R, Ordenes K, Orrego PR, Gonzalez J, Araya JE, Catalan A (2017) Phospholipase D from loxosceles laeta spider venom induces IL-6, IL-8, CXCL1\/GRO-alpha, and CCL2\/MCP-1 production in human skin fibroblasts and stimulates monocytes migration. Toxins 9(4). https:\/\/doi.org\/10.3390\/toxins9040125","DOI":"10.3390\/toxins9040125"},{"issue":"7","key":"3_CR271","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1074\/jbc.M306642200","volume":"279","author":"Y Okamoto","year":"2004","unstructured":"Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 279(7):5298\u20135305. https:\/\/doi.org\/10.1074\/jbc.M306642200","journal-title":"J Biol Chem"},{"issue":"3","key":"3_CR272","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.str.2014.12.018","volume":"23","author":"P Magotti","year":"2015","unstructured":"Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G (2015) Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure 23(3):598\u2013604. https:\/\/doi.org\/10.1016\/j.str.2014.12.018","journal-title":"Structure"},{"issue":"3-4","key":"3_CR273","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10555-011-9319-7","volume":"30","author":"AJ Houben","year":"2011","unstructured":"Houben AJ, Moolenaar WH (2011) Autotaxin and LPA receptor signaling in cancer. Cancer Metastasis Rev 30(3-4):557\u2013565. https:\/\/doi.org\/10.1007\/s10555-011-9319-7","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"3_CR274","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nsmb.1980","volume":"18","author":"J Hausmann","year":"2011","unstructured":"Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A (2011) Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol 18(2):198\u2013204. https:\/\/doi.org\/10.1038\/nsmb.1980","journal-title":"Nat Struct Mol Biol"},{"key":"3_CR275","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1021\/acsmedchemlett.6b00207","volume":"7","author":"SB Jones","year":"2016","unstructured":"Jones SB, Pfeifer LA, Bleisch TJ, Beauchamp TJ, Durbin JD, Klimkowski VJ, Hughes NE, Rito CJ, Dao Y, Gruber JM, Bui H, Chambers MG, Chandrasekhar S, Lin C, McCann DJ, Mudra DR, Oskins JL, Swearingen CA, Thirunavukkarasu K, Norman BH (2016) Novel autotaxin inhibitors for the treatment of osteoarthritis pain: lead optimization via structure-based drug design. ACS Med Chem Lett 7:857\u2013861. https:\/\/doi.org\/10.1021\/acsmedchemlett.6b00207","journal-title":"ACS Med Chem Lett"}],"container-title":["Methods in Molecular Biology","Lipases and Phospholipases"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-8672-9_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:49:02Z","timestamp":1661752142000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-8672-9_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9781493986712","9781493986729"],"references-count":275,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-8672-9_3","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}