{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T01:40:09Z","timestamp":1751852409774,"version":"3.41.0"},"publisher-location":"New York, NY","reference-count":29,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493987023"},{"type":"electronic","value":"9781493987047"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-1-4939-8704-7_7","type":"book-chapter","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:54:59Z","timestamp":1536566099000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Indirect Measurement of CRAC Channel Activity Using NFAT Nuclear Translocation by Flow Cytometry in Jurkat Cells"],"prefix":"10.1007","author":[{"given":"Mar\u00eda D.","family":"Carretta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael A.","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"issue":"2","key":"7_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/ni.2796","volume":"15","author":"PK Chattopadhyay","year":"2014","unstructured":"Chattopadhyay PK, Gierahn TM, Roederer M et al (2014) Single-cell technologies for monitoring immune systems. Nat Immunol 15(2):128\u2013135","journal-title":"Nat Immunol"},{"issue":"4","key":"7_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nmeth0411-311","volume":"8","author":"T Kalisky","year":"2011","unstructured":"Kalisky T, Quake SR (2011) Single-cell genomics. Nat Methods 8(4):311\u2013314","journal-title":"Nat Methods"},{"issue":"18","key":"7_CR3","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1101\/gad.1102703","volume":"17","author":"PG Hogan","year":"2003","unstructured":"Hogan PG, Chen L, Nardone J et\u00a0al (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17(18):2205\u20132232","journal-title":"Genes Dev"},{"issue":"Suppl","key":"7_CR4","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","volume":"109","author":"GR Crabtree","year":"2002","unstructured":"Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell 109(Suppl):S67\u2013S79","journal-title":"Cell"},{"key":"7_CR5","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","volume":"15","author":"A Rao","year":"1997","unstructured":"Rao A, Luo C, Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707\u2013747","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"7_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00424-004-1364-4","volume":"450","author":"A Quintana","year":"2005","unstructured":"Quintana A, Griesemer D, Schwarz EC, Hoth M (2005) Calcium-dependent activation of T-lymphocytes. Pflugers Arch 450(1):1\u201312","journal-title":"Pflugers Arch"},{"issue":"3","key":"7_CR7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s12013-013-9728-z","volume":"68","author":"E Jara","year":"2014","unstructured":"Jara E, Hidalgo MA, Hancke JL et al (2014) Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells. Cell Biochem Biophys 68(3):497\u2013509","journal-title":"Cell Biochem Biophys"},{"issue":"2","key":"7_CR8","first-page":"84","volume":"1","author":"JW Putney Jr","year":"2001","unstructured":"Putney JW Jr (2001) Pharmacology of capacitative calcium entry. Mol Interv 1(2):84\u201394","journal-title":"Mol Interv"},{"issue":"13","key":"7_CR9","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.1073\/pnas.81.13.4169","volume":"81","author":"A Weiss","year":"1984","unstructured":"Weiss A, Imboden J, Shoback D et al (1984) Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci U S A 81(13):4169\u20134173","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"7_CR10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-3565(24)29323-X","volume":"299","author":"BS Fischer","year":"2001","unstructured":"Fischer BS, Qin D, Kim K et al (2001) Capsaicin inhibits Jurkat T-cell activation by blocking calcium entry current I(CRAC). J Pharmacol Exp Ther 299(1):238\u2013246","journal-title":"J Pharmacol Exp Ther"},{"issue":"2\u20133","key":"7_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0014-2999(00)00144-8","volume":"394","author":"JH Li","year":"2000","unstructured":"Li JH, Spence KT, Dargis PG et al (2000) Properties of Ca(2+) release-activated Ca(2+) channel block by 5-nitro-2-(3-phenylpropylamino)-benzoic acid in Jurkat cells. Eur J Pharmacol 394(2\u20133):171\u2013179","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"7_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.rvsc.2010.10.005","volume":"92","author":"I Conejeros","year":"2012","unstructured":"Conejeros I, Jara E, Carretta MD et al (2012) 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. Res Vet Sci 92(1):103\u2013110","journal-title":"Res Vet Sci"},{"issue":"1\u20132","key":"7_CR13","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.vetimm.2011.12.006","volume":"145","author":"I Conejeros","year":"2012","unstructured":"Conejeros I, Velasquez ZvD, Carretta MD et al (2012) 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. Vet Immunol Immunopathol 145(1\u20132):540\u2013545","journal-title":"Vet Immunol Immunopathol"},{"issue":"28","key":"7_CR14","doi-asserted-by":"publisher","first-page":"19265","DOI":"10.1074\/jbc.M801535200","volume":"283","author":"WI DeHaven","year":"2008","unstructured":"DeHaven WI, Smyth JT, Boyles RR et al (2008) Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem 283(28):19265\u201319273","journal-title":"J Biol Chem"},{"issue":"34","key":"7_CR15","doi-asserted-by":"publisher","first-page":"24979","DOI":"10.1074\/jbc.M604589200","volume":"281","author":"JC Mercer","year":"2006","unstructured":"Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, Putney JW Jr (2006) Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem 281(34):24979\u201324990","journal-title":"J Biol Chem"},{"issue":"4","key":"7_CR16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1124\/mi.10.4.4","volume":"10","author":"JW Putney","year":"2010","unstructured":"Putney JW (2010) Pharmacology of store-operated calcium channels. Mol Interv 10(4):209\u2013218","journal-title":"Mol Interv"},{"issue":"9","key":"7_CR17","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.4049\/jimmunol.170.9.4441","volume":"170","author":"J Ishikawa","year":"2003","unstructured":"Ishikawa J, Ohga K, Yoshino T et al (2003) A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol 170(9):4441\u20134449","journal-title":"J Immunol"},{"issue":"13","key":"7_CR18","doi-asserted-by":"publisher","first-page":"12427","DOI":"10.1074\/jbc.M309297200","volume":"279","author":"C Zitt","year":"2004","unstructured":"Zitt C, Strauss B, Schwarz EC et al (2004) Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem 279(13):12427\u201312437","journal-title":"J Biol Chem"},{"issue":"2","key":"7_CR19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/S0008-8749(03)00005-4","volume":"220","author":"Y Chen","year":"2002","unstructured":"Chen Y, Smith ML, Chiou GX et al (2002) TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators. Cell Immunol 220(2):134\u2013142","journal-title":"Cell Immunol"},{"issue":"51","key":"7_CR20","doi-asserted-by":"publisher","first-page":"48118","DOI":"10.1074\/jbc.M107919200","volume":"276","author":"JM Trevillyan","year":"2001","unstructured":"Trevillyan JM, Chiou XG, Chen YW et al (2001) Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds. J Biol Chem 276(51):48118\u201348126","journal-title":"J Biol Chem"},{"key":"7_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1746-4811-9-31","volume":"9","author":"S Sikorskaite","year":"2013","unstructured":"Sikorskaite S, Rajamaki ML, Baniulis D et al (2013) Protocol: optimised methodology for isolation of nuclei from leaves of species in the Solanaceae and Rosaceae families. Plant Methods 9:31","journal-title":"Plant Methods"},{"key":"7_CR22","doi-asserted-by":"crossref","unstructured":"Wilkie GS, Schirmer EC (2008) Purification of nuclei and preparation of nuclear envelopes from skeletal muscle. Methods Mol Biol 463:23\u201341","DOI":"10.1007\/978-1-59745-406-3_2"},{"key":"7_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0091-679X(08)60218-6","volume":"15","author":"M Muramatsu","year":"1977","unstructured":"Muramatsu M, Onishi T (1977) Rapid isolation of nucleoli from detergent-purified nuclei of tumor and tissue culture cells. Methods Cell Biol 15:221\u2013234","journal-title":"Methods Cell Biol"},{"issue":"2","key":"7_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0014-4827(75)90125-1","volume":"91","author":"L Kuehl","year":"1975","unstructured":"Kuehl L (1975) Isolation of skeletal muscle nuclei. Exp Cell Res 91(2):441\u2013448","journal-title":"Exp Cell Res"},{"issue":"2","key":"7_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/cyto.10115","volume":"48","author":"A Blaecke","year":"2002","unstructured":"Blaecke A, Delneste Y, Herbault N et al (2002) Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry. Cytometry 48(2):71\u201379","journal-title":"Cytometry"},{"issue":"28","key":"7_CR26","doi-asserted-by":"publisher","first-page":"17559","DOI":"10.1074\/jbc.273.28.17559","volume":"273","author":"P Juin","year":"1998","unstructured":"Juin P, Pelletier M, Oliver L et al (1998) Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. J Biol Chem 273(28):17559\u201317564","journal-title":"J Biol Chem"},{"key":"7_CR27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4939-2152-2_3","volume":"1254","author":"N L\u00f3pez-S\u00e1nchez","year":"2015","unstructured":"L\u00f3pez-S\u00e1nchez N, Frade J (2015) Flow cytometric analysis of DNA synthesis and apoptosis in central nervous system using fresh cell nuclei. Neuronal Cell Death 1254:33\u201342","journal-title":"Neuronal Cell Death"},{"issue":"16","key":"7_CR28","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1021\/jm990615a","volume":"43","author":"SW Djuric","year":"2000","unstructured":"Djuric SW, BaMaung NY, Basha A et al (2000) 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem 43(16):2975\u20132981","journal-title":"J Med Chem"},{"issue":"2\u20133","key":"7_CR29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ejphar.2008.11.011","volume":"602","author":"MD Carretta","year":"2009","unstructured":"Carretta MD, Alarcon P, Jara E et al (2009) Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation. Eur J Pharmacol 602(2\u20133):413\u2013421","journal-title":"Eur J Pharmacol"}],"container-title":["Methods in Molecular Biology","The CRAC Channel"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-8704-7_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T01:17:29Z","timestamp":1751851049000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-8704-7_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9781493987023","9781493987047"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-8704-7_7","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2018]]}}}