{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T22:55:34Z","timestamp":1771800934945,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":14,"publisher":"Springer New York","isbn-type":[{"value":"9781493988754","type":"print"},{"value":"9781493988761","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-1-4939-8876-1_24","type":"book-chapter","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T07:26:54Z","timestamp":1540193214000},"page":"355-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-Throughput Sequencing of the T-Cell Receptor Beta Chain Gene Repertoire in Chronic Lymphocytic Leukemia"],"prefix":"10.1007","author":[{"given":"E.","family":"Vlachonikola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hadzidimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"24_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/sj.leu.2404467","volume":"21","author":"JH Krieken Van","year":"2007","unstructured":"Van Krieken JH, Langerak AW, Macintyre EA et al (2007) Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 21:201\u2013206","journal-title":"Leukemia"},{"key":"24_CR2","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","volume":"94","author":"RN Damle","year":"1999","unstructured":"Damle RN, Wasil T, Fais F et al (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840\u20131847","journal-title":"Blood"},{"key":"24_CR3","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","volume":"94","author":"TJ Hamblin","year":"1999","unstructured":"Hamblin TJ, Davis Z, Gardiner A et al (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94:1848\u20131354","journal-title":"Blood"},{"key":"24_CR4","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1182\/blood.V99.12.4386","volume":"99","author":"MJ Willemse","year":"2002","unstructured":"Willemse MJ, Seriu T, Hettinger K et al (2002) Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL. Blood 99:4386\u20134393","journal-title":"Blood"},{"key":"24_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1158\/1078-0432.CCR-14-3017","volume":"22","author":"A Vardi","year":"2016","unstructured":"Vardi A, Agathangelidis A, Stalika E et al (2016) Antigen selection shapes the T-cell repertoire in chronic lymphocytic leukemia. Clin Cancer Res 22:167\u2013174","journal-title":"Clin Cancer Res"},{"key":"24_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1126\/scitranslmed.3000540","volume":"1","author":"SD Boyd","year":"2009","unstructured":"Boyd SD, Marshall EL, Merker JD et al (2009) Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci Transl Med 1:12\u201323","journal-title":"Sci Transl Med"},{"key":"24_CR7","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1182\/blood-2010-03-275859","volume":"116","author":"YC Wu","year":"2010","unstructured":"Wu YC, Kipling D, Leong HS et al (2010) High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood 116:1070\u20131078","journal-title":"Blood"},{"key":"24_CR8","doi-asserted-by":"publisher","first-page":"21194","DOI":"10.1073\/pnas.1118357109","volume":"108","author":"AC Logan","year":"2011","unstructured":"Logan AC, Gao H, Wang C et al (2011) High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment. Proc Natl Acad Sci U S A 108:21194\u201321199","journal-title":"Proc Natl Acad Sci U S A"},{"key":"24_CR9","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1101\/gr.092924.109","volume":"19","author":"JD Freeman","year":"2009","unstructured":"Freeman JD, Warren RL, Webb JR et al (2009) Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res 19:1817\u20131824","journal-title":"Genome Res"},{"key":"24_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1126\/scitranslmed.3001442","volume":"2","author":"HS Robins","year":"2010","unstructured":"Robins HS, Srivastava SK, Campregher PV et al (2010) Overlap and effective size of the human CD8+ T cell receptor repertoire. Sci Transl Med 2:47\u201364","journal-title":"Sci Transl Med"},{"key":"24_CR11","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1073\/pnas.0913939107","volume":"107","author":"C Wang","year":"2010","unstructured":"Wang C, Sanders CM, Yang Q et al (2010) High-throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci U S A 107:1518\u20131523","journal-title":"Proc Natl Acad Sci U S A"},{"key":"24_CR12","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1038\/ncomms3333","volume":"4","author":"S Li","year":"2013","unstructured":"Li S, Lefranc MP, Miles JJ et al (2013) IMGT\/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nat Commun 4:2333","journal-title":"Nat Commun"},{"key":"24_CR13","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/leu.2016.362","volume":"31","author":"A Vardi","year":"2017","unstructured":"Vardi A, Vlachonikola E, Karypidou M et al (2017) Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements. Leukemia 31:1555\u20131561","journal-title":"Leukemia"},{"key":"24_CR14","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJM Dongen van","year":"2003","unstructured":"van Dongen JJM, Langerak AW, Bruggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257\u20132317","journal-title":"Leukemia"}],"container-title":["Methods in Molecular Biology","Chronic Lymphocytic Leukemia"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-8876-1_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T11:23:21Z","timestamp":1572175401000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-8876-1_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"ISBN":["9781493988754","9781493988761"],"references-count":14,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-8876-1_24","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]}}}