{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:10Z","timestamp":1790061310194,"version":"4.0.1"},"publisher-location":"New York, NY","reference-count":101,"publisher":"Springer New York","isbn-type":[{"value":"9781493994236","type":"print"},{"value":"9781493994243","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-1-4939-9424-3_38","type":"book-chapter","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T08:03:34Z","timestamp":1559808214000},"page":"695-713","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["NADPH Oxidases in Inflammatory Bowel Disease"],"prefix":"10.1007","author":[{"given":"Emily","family":"Stenke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla G.","family":"Knaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"issue":"7","key":"38_CR1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/archdischild-2011-300651","volume":"97","author":"B Hope","year":"2012","unstructured":"Hope B, Shahdadpuri R, Dunne C et al (2012) Rapid rise in incidence of Irish paediatric inflammatory bowel disease. Arch Dis Child 97(7):590\u2013594. \n                    https:\/\/doi.org\/10.1136\/archdischild-2011-300651","journal-title":"Arch Dis Child"},{"issue":"1","key":"38_CR2","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/ibd.21349","volume":"17","author":"EI Benchimol","year":"2011","unstructured":"Benchimol EI, Fortinsky KJ, Gozdyra P et al (2011) Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 17(1):423\u2013439. \n                    https:\/\/doi.org\/10.1002\/ibd.21349","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"38_CR3","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1053\/j.gastro.2014.06.023","volume":"147","author":"EI Benchimol","year":"2014","unstructured":"Benchimol EI, Mack DR, Nguyen GC et al (2014) Incidence, outcomes, and health services burden of very early onset inflammatory Bowel disease. Gastroenterology 147(4):803\u2013813.e807. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2014.06.023","journal-title":"Gastroenterology"},{"issue":"6","key":"38_CR4","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/ibd.21493","volume":"17","author":"A Levine","year":"2011","unstructured":"Levine A, Griffiths A, Markowitz J et al (2011) Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis 17(6):1314\u20131321. \n                    https:\/\/doi.org\/10.1002\/ibd.21493","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"38_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jpeds.2004.08.043","volume":"146","author":"MB Heyman","year":"2005","unstructured":"Heyman MB, Kirschner BS, Gold BD et al (2005) Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr 146(1):35\u201340. \n                    https:\/\/doi.org\/10.1016\/j.jpeds.2004.08.043","journal-title":"J Pediatr"},{"issue":"4","key":"38_CR6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1097\/01.mib.0000442921.77945.09","volume":"20","author":"M Aloi","year":"2014","unstructured":"Aloi M, Lionetti P, Barabino A et al (2014) Phenotype and disease course of early-onset pediatric inflammatory bowel disease. Inflamm Bowel Dis 20(4):597\u2013605. \n                    https:\/\/doi.org\/10.1097\/01.mib.0000442921.77945.09","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"38_CR7","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1053\/j.gastro.2014.07.023","volume":"147","author":"HH Uhlig","year":"2014","unstructured":"Uhlig HH, Schwerd T, Koletzko S et al (2014) The diagnostic approach to monogenic very early onset inflammatory Bowel disease. Gastroenterology 147(5):990\u20131007.e1003. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2014.07.023","journal-title":"Gastroenterology"},{"issue":"7","key":"38_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/00004836-200608000-00004","volume":"40","author":"T Paul","year":"2006","unstructured":"Paul T, Birnbaum A, Pal DK et al (2006) Distinct phenotype of early childhood inflammatory bowel disease. J Clin Gastroenterol 40(7):583\u2013586","journal-title":"J Clin Gastroenterol"},{"issue":"3","key":"38_CR9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/MPG.0b013e318231d984","volume":"54","author":"CI Bie de","year":"2012","unstructured":"de Bie CI, Buderus S, Sandhu BK et al (2012) Diagnostic workup of paediatric patients with inflammatory bowel disease in Europe: results of a 5-year audit of the EUROKIDS registry. J Pediatr Gastroenterol Nutr 54(3):374\u2013380. \n                    https:\/\/doi.org\/10.1097\/MPG.0b013e318231d984","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7422","key":"38_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK et al (2012) Host\u2013microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491(7422):119\u2013124. \n                    https:\/\/doi.org\/10.1038\/nature11582","journal-title":"Nature"},{"issue":"7","key":"38_CR11","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/ibd.20380","volume":"14","author":"ME Spehlmann","year":"2008","unstructured":"Spehlmann ME, Begun AZ, Burghardt J et al (2008) Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis 14(7):968\u2013976. \n                    https:\/\/doi.org\/10.1002\/ibd.20380","journal-title":"Inflamm Bowel Dis"},{"issue":"7351","key":"38_CR12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature10209","volume":"474","author":"B Khor","year":"2011","unstructured":"Khor B, Gardet A, Xavier RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474(7351):307\u2013317. \n                    https:\/\/doi.org\/10.1038\/nature10209","journal-title":"Nature"},{"issue":"5","key":"38_CR13","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/ecco-jcc\/jjw194","volume":"11","author":"E Bequet","year":"2017","unstructured":"Bequet E, Sarter H, Fumery M et al (2017) Incidence and phenotype at diagnosis of very-early-onset compared with later-onset paediatric inflammatory bowel disease: a population-based study [1988\u20132011]. J Crohns Colitis 11(5):519\u2013526. \n                    https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw194","journal-title":"J Crohns Colitis"},{"issue":"6","key":"38_CR14","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/mpg.0000000000000239","volume":"58","author":"A Levine","year":"2014","unstructured":"Levine A, Koletzko S, Turner D et al (2014) ESPGHAN revised Porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr 58(6):795\u2013806. \n                    https:\/\/doi.org\/10.1097\/mpg.0000000000000239","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"38_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/00005176-200409000-00006","volume":"39","author":"SP Castellaneta","year":"2004","unstructured":"Castellaneta SP, Afzal NA, Greenberg M et al (2004) Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 39(3):257\u2013261","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"8","key":"38_CR16","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1111\/j.1572-0241.2002.05915.x","volume":"97","author":"P Mamula","year":"2002","unstructured":"Mamula P, Telega GW, Markowitz JE et al (2002) Inflammatory bowel disease in children 5 years of age and younger. Am J Gastroenterol 97(8):2005\u20132010. \n                    https:\/\/doi.org\/10.1111\/j.1572-0241.2002.05915.x","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"38_CR17","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1111\/apt.14070","volume":"45","author":"A Coughlan","year":"2017","unstructured":"Coughlan A, Wylde R, Lafferty L et al (2017) A rising incidence and poorer male outcomes characterise early onset paediatric inflammatory bowel disease. Aliment Pharmacol Ther 45(12):1534\u20131541. \n                    https:\/\/doi.org\/10.1111\/apt.14070","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"38_CR18","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.cgh.2015.10.030","volume":"14","author":"SK Khangura","year":"2016","unstructured":"Khangura SK, Kamal N, Ho N et al (2016) Gastrointestinal features of chronic granulomatous disease found during endoscopy. Clin Gastroenterol Hepatol 14(3):395\u2013402.e395. \n                    https:\/\/doi.org\/10.1016\/j.cgh.2015.10.030","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"14","key":"38_CR19","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1089\/ars.2012.4530","volume":"19","author":"F Biasi","year":"2013","unstructured":"Biasi F, Leonarduzzi G, Oteiza PI et al (2013) Inflammatory Bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal 19(14):1711\u20131747. \n                    https:\/\/doi.org\/10.1089\/ars.2012.4530","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"38_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause K-H (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87(1):245\u2013313","journal-title":"Physiol Rev"},{"key":"38_CR21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-pathol-012513-104651","volume":"9","author":"JD Lambeth","year":"2014","unstructured":"Lambeth JD, Neish AS (2014) Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited. Annu Rev Pathol 9:119\u2013145. \n                    https:\/\/doi.org\/10.1146\/annurev-pathol-012513-104651","journal-title":"Annu Rev Pathol"},{"key":"38_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.redox.2015.07.009","volume":"6","author":"S O\u2019Neill","year":"2015","unstructured":"O\u2019Neill S, Brault J, Stasia M-J, Knaus UG (2015) Genetic disorders coupled to ROS deficiency. Redox Biol 6:135\u2013156. \n                    https:\/\/doi.org\/10.1016\/j.redox.2015.07.009","journal-title":"Redox Biol"},{"issue":"13","key":"38_CR23","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1111\/j.1742-4658.2008.06488.x","volume":"275","author":"H Sumimoto","year":"2008","unstructured":"Sumimoto H (2008) Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J 275(13):3249\u20133277. \n                    https:\/\/doi.org\/10.1111\/j.1742-4658.2008.06488.x","journal-title":"FEBS J"},{"issue":"2","key":"38_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/cei.12202","volume":"175","author":"D Roos","year":"2014","unstructured":"Roos D, Boer M (2014) Molecular diagnosis of chronic granulomatous disease. Clin Exp Immunol 175(2):139\u2013149. \n                    https:\/\/doi.org\/10.1111\/cei.12202","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"38_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.hoc.2012.11.002","volume":"27","author":"SM Holland","year":"2013","unstructured":"Holland SM (2013) Chronic granulomatous disease. Hematol Oncol Clin North Am 27(1):89\u201399. \n                    https:\/\/doi.org\/10.1016\/j.hoc.2012.11.002","journal-title":"Hematol Oncol Clin North Am"},{"issue":"1","key":"38_CR26","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ajg.2008.72","volume":"104","author":"DJ Marks","year":"2009","unstructured":"Marks DJ, Miyagi K, Rahman FZ et al (2009) Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn\u2019s disease. Am J Gastroenterol 104(1):117\u2013124. \n                    https:\/\/doi.org\/10.1038\/ajg.2008.72","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"38_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1136\/adc.84.2.147","volume":"84","author":"MG Schappi","year":"2001","unstructured":"Schappi MG, Smith VV, Goldblatt D et al (2001) Colitis in chronic granulomatous disease. Arch Dis Child 84(2):147\u2013151","journal-title":"Arch Dis Child"},{"issue":"3","key":"38_CR28","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1053\/j.gastro.2014.06.005","volume":"147","author":"SS Dhillon","year":"2014","unstructured":"Dhillon SS, Fattouh R, Elkadri A et al (2014) Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory Bowel disease. Gastroenterology 147(3):680\u2013689.e682. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2014.06.005","journal-title":"Gastroenterology"},{"issue":"8","key":"38_CR29","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1053\/j.gastro.2018.02.016","volume":"154","author":"LA Denson","year":"2018","unstructured":"Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou DT, Dodd A, Quinn K, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan S (2018) Clinical and genomic correlates of neutrophil reactive oxygen species production in pediatric patients with Crohn\u2019s disease. Gastroenterology 154(8):2097\u20132110. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2018.02.016","journal-title":"Gastroenterology"},{"issue":"5037","key":"38_CR30","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1126\/science.1660188","volume":"254","author":"UG Knaus","year":"1991","unstructured":"Knaus UG, Heyworth PG, Evans T et al (1991) Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254(5037):1512\u20131515","journal-title":"Science"},{"key":"38_CR31","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.27952","volume":"5","author":"E Pick","year":"2014","unstructured":"Pick E (2014) Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task. Small GTPases 5:e27952. \n                    https:\/\/doi.org\/10.4161\/sgtp.27952","journal-title":"Small GTPases"},{"issue":"7","key":"38_CR32","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1136\/gutjnl-2011-300078","volume":"61","author":"AM Muise","year":"2012","unstructured":"Muise AM, Xu W, Guo CH et al (2012) NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut 61(7):1028\u20131035. \n                    https:\/\/doi.org\/10.1136\/gutjnl-2011-300078","journal-title":"Gut"},{"key":"38_CR33","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/ng2032","volume":"39","author":"JD Rioux","year":"2007","unstructured":"Rioux JD, Xavier RJ, Taylor KD et al (2007) Genome-wide association study identifies new susceptibility loci for Crohn\u2019s disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596. \n                    https:\/\/doi.org\/10.1038\/ng2032","journal-title":"Nat Genet"},{"key":"38_CR34","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/gene.2008.49","volume":"9","author":"RL Roberts","year":"2008","unstructured":"Roberts RL, Hollis-Moffatt JE, Gearry RB et al (2008) Confirmation of association of IRGM and NCF4 with ileal Crohn\u2019s disease in a population-based cohort. Genes Immun 9:561. \n                    https:\/\/doi.org\/10.1038\/gene.2008.49","journal-title":"Genes Immun"},{"issue":"3","key":"38_CR35","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/ajg.2008.65","volume":"104","author":"J Glas","year":"2009","unstructured":"Glas J, Seiderer J, Pasciuto G et al (2009) rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn\u2019s disease in the German population. Am J Gastroenterol 104(3):665\u2013672. \n                    https:\/\/doi.org\/10.1038\/ajg.2008.65","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"38_CR36","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/ibd.21708","volume":"18","author":"DK Amre","year":"2012","unstructured":"Amre DK, Mack DR, Israel D et al (2012) NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn\u2019s disease in Canadian children and young adults. Inflamm Bowel Dis 18(3):529\u2013535. \n                    https:\/\/doi.org\/10.1002\/ibd.21708","journal-title":"Inflamm Bowel Dis"},{"issue":"7","key":"38_CR37","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1136\/gutjnl-2011-301344","volume":"61","author":"R Somasundaram","year":"2012","unstructured":"Somasundaram R, Deuring JJ, van der Woude CJ et al (2012) Linking risk conferring mutations in NCF4 to functional consequences in Crohn\u2019s disease. Gut 61(7):1097","journal-title":"Gut"},{"issue":"8","key":"38_CR38","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1084\/jem.20052069","volume":"203","author":"CD Ellson","year":"2006","unstructured":"Ellson CD, Davidson K, Ferguson GJ et al (2006) Neutrophils from p40phox\u2212\/\u2212 mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med 203(8):1927\u20131937. \n                    https:\/\/doi.org\/10.1084\/jem.20052069","journal-title":"J Exp Med"},{"issue":"8","key":"38_CR39","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1136\/gut.25.8.849","volume":"25","author":"HW Verspaget","year":"1984","unstructured":"Verspaget HW, Mieremet-Ooms MA, Weterman IT et al (1984) Partial defect of neutrophil oxidative metabolism in Crohn\u2019s disease. Gut 25(8):849\u2013853","journal-title":"Gut"},{"issue":"11","key":"38_CR40","doi-asserted-by":"publisher","first-page":"e7787","DOI":"10.1371\/journal.pone.0007787","volume":"4","author":"Christine D. Palmer","year":"2009","unstructured":"Palmer CD, Rahman FZ, Sewell GW et al (2009) Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn\u2019s disease. PLoS One 4(11):e7787. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0007787","journal-title":"PLoS ONE"},{"issue":"1","key":"38_CR41","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/00365528209181050","volume":"17","author":"N Worsaae","year":"1982","unstructured":"Worsaae N, Staehr Johansen K, Christensen KC (1982) Impaired in vitro function of neutrophils in Crohn\u2019s disease. Scand J Gastroenterol 17(1):91\u201396","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"38_CR42","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.clim.2003.08.002","volume":"109","author":"M Anderson-Cohen","year":"2003","unstructured":"Anderson-Cohen M, Holland SM, Kuhns DB et al (2003) Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation. Clin Immunol 109(3):308\u2013317","journal-title":"Clin Immunol"},{"issue":"23","key":"38_CR43","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1056\/nejm200012073432307","volume":"343","author":"JA Lekstrom-Himes","year":"2000","unstructured":"Lekstrom-Himes JA, Gallin JI (2000) Immunodeficiency diseases caused by defects in phagocytes. N Engl J Med 343(23):1703\u20131714. \n                    https:\/\/doi.org\/10.1056\/nejm200012073432307","journal-title":"N Engl J Med"},{"issue":"1","key":"38_CR44","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jaci.2017.04.035","volume":"141","author":"BE Marciano","year":"2018","unstructured":"Marciano BE, Zerbe CS, Falcone EL et al (2018) X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability. J Allergy Clin Immunol 141(1):365\u2013371. \n                    https:\/\/doi.org\/10.1016\/j.jaci.2017.04.035","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"38_CR45","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1097\/mib.0000000000000966","volume":"22","author":"C Huang","year":"2016","unstructured":"Huang C, De Ravin SS, Paul AR et al (2016) Genetic risk for inflammatory Bowel disease is a determinant of Crohn\u2019s disease development in chronic granulomatous disease. Inflamm Bowel Dis 22(12):2794\u20132801. \n                    https:\/\/doi.org\/10.1097\/mib.0000000000000966","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"38_CR46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1056\/nejm199901213400317","volume":"340","author":"D Vaughan","year":"1999","unstructured":"Vaughan D, Drumm B (1999) Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn\u2019s disease. N Engl J Med 340(3):239\u2013240. \n                    https:\/\/doi.org\/10.1056\/nejm199901213400317","journal-title":"N Engl J Med"},{"issue":"12","key":"38_CR47","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1038\/ajg.2013.360","volume":"108","author":"J Dabritz","year":"2013","unstructured":"Dabritz J, Bonkowski E, Chalk C (2013) Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease. Am J Gastroenterol 108(12):1901\u20131910. \n                    https:\/\/doi.org\/10.1038\/ajg.2013.360","journal-title":"Am J Gastroenterol"},{"issue":"27","key":"38_CR48","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","volume":"363","author":"DB Kuhns","year":"2010","unstructured":"Kuhns DB, Alvord WG, Heller T et al (2010) Residual NADPH oxidase and survival in chronic granulomatous disease. N Engl J Med 363(27):2600\u20132610. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1007097","journal-title":"N Engl J Med"},{"issue":"33","key":"38_CR49","doi-asserted-by":"publisher","first-page":"6137","DOI":"10.3748\/wjg.v23.i33.6137","volume":"23","author":"ML Halling","year":"2017","unstructured":"Halling ML, Kjeldsen J, Knudsen T et al (2017) Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases. World J Gastroenterol 23(33):6137\u20136146. \n                    https:\/\/doi.org\/10.3748\/wjg.v23.i33.6137","journal-title":"World J Gastroenterol"},{"issue":"12","key":"38_CR50","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1136\/gutjnl-2012-303956","volume":"62","author":"HH Uhlig","year":"2013","unstructured":"Uhlig HH (2013) Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease. Gut 62(12):1795\u20131805. \n                    https:\/\/doi.org\/10.1136\/gutjnl-2012-303956","journal-title":"Gut"},{"issue":"4","key":"38_CR51","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1053\/j.gastro.2014.01.015","volume":"146","author":"Y Avitzur","year":"2014","unstructured":"Avitzur Y, Guo C, Mastropaolo LA et al (2014) Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology 146(4):1028\u20131039. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2014.01.015","journal-title":"Gastroenterology"},{"issue":"6","key":"38_CR52","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jaci.2008.08.026","volume":"122","author":"SY Pai","year":"2008","unstructured":"Pai SY, Levy O, Jabara HH et al (2008) Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol 122(6):1113\u20131118.e1111. \n                    https:\/\/doi.org\/10.1016\/j.jaci.2008.08.026","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"38_CR53","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/j.1365-2133.2008.08507.x","volume":"158","author":"EB Freeman","year":"2008","unstructured":"Freeman EB, Koglmeier J, Martinez AE et al (2008) Gastrointestinal complications of epidermolysis bullosa in children. Br J Dermatol 158(6):1308\u20131314. \n                    https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08507.x","journal-title":"Br J Dermatol"},{"issue":"3","key":"38_CR54","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/ced.12114","volume":"38","author":"H Reddy","year":"2013","unstructured":"Reddy H, Shipman AR, Wojnarowska F (2013) Epidermolysis bullosa acquisita and inflammatory bowel disease: a review of the literature. Clin Exp Dermatol 38(3):225\u2013229.; quiz 229-230. \n                    https:\/\/doi.org\/10.1111\/ced.12114","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"38_CR55","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1097\/MIB.0b013e318281f454","volume":"19","author":"V Kumar","year":"2013","unstructured":"Kumar V, Mack DR, Marcil V et al (2013) Genome-wide association study signal at the 12q12 locus for Crohn\u2019s disease may represent associations with the MUC19 gene. Inflamm Bowel Dis 19(6):1254\u20131259. \n                    https:\/\/doi.org\/10.1097\/MIB.0b013e318281f454","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"38_CR56","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1096\/fj.02-1104fje","volume":"17","author":"M Geiszt","year":"2003","unstructured":"Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL (2003) Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J 17(11):1502\u20131504. \n                    https:\/\/doi.org\/10.1096\/fj.02-1104fje","journal-title":"FASEB J"},{"issue":"5","key":"38_CR57","doi-asserted-by":"publisher","first-page":"G933","DOI":"10.1152\/ajpgi.00198.2004","volume":"288","author":"RA Hassani El","year":"2005","unstructured":"El Hassani RA, Benfares N, Caillou B et al (2005) Dual oxidase2 is expressed all along the digestive tract. Am J Physiol Gastrointest Liver Physiol 288(5):G933\u2013G942. \n                    https:\/\/doi.org\/10.1152\/ajpgi.00198.2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"38_CR58","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00281-008-0124-5","volume":"30","author":"K Rokutan","year":"2008","unstructured":"Rokutan K, Kawahara T, Kuwano Y et al (2008) Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol 30(3):315\u2013327. \n                    https:\/\/doi.org\/10.1007\/s00281-008-0124-5","journal-title":"Semin Immunopathol"},{"issue":"7","key":"38_CR59","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1053\/j.gastro.2015.07.062","volume":"149","author":"H Grasberger","year":"2015","unstructured":"Grasberger H, Gao J, Nagao-Kitamoto H et al (2015) Increased expression of DUOX2 is an epithelial response to mucosal dysbiosis required for immune homeostasis in mouse intestine. Gastroenterology 149(7):1849\u20131859. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2015.07.062","journal-title":"Gastroenterology"},{"issue":"6","key":"38_CR60","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1128\/MCB.26.6.2160-2174.2006","volume":"26","author":"T Ueyama","year":"2006","unstructured":"Ueyama T, Geiszt M, Leto TL (2006) Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol Cell Biol 26(6):2160\u20132174. \n                    https:\/\/doi.org\/10.1128\/MCB.26.6.2160-2174.2006","journal-title":"Mol Cell Biol"},{"issue":"5","key":"38_CR61","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jcmgh.2015.06.005","volume":"1","author":"P Hayes","year":"2015","unstructured":"Hayes P, Dhillon S, O\u2019Neill K et al (2015) Defects in NADPH oxidase genes NOX1 and DUOX2 in very early onset inflammatory Bowel disease. Cell Mol Gastroenterol Hepatol 1(5):489\u2013502. \n                    https:\/\/doi.org\/10.1016\/j.jcmgh.2015.06.005","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"38_CR62","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/mi.2017.74","volume":"11","author":"T Schwerd","year":"2017","unstructured":"Schwerd T, Bryant RV, Pandey S et al (2018) NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunol 11(2):562\u2013574. \n                    https:\/\/doi.org\/10.1038\/mi.2017.74","journal-title":"Mucosal Immunology"},{"issue":"3","key":"38_CR63","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","volume":"15","author":"D Gevers","year":"2014","unstructured":"Gevers D, Kugathasan S, Denson LA et al (2014) The treatment-naive microbiome in new-onset Crohn\u2019s disease. Cell Host Microbe 15(3):382\u2013392. \n                    https:\/\/doi.org\/10.1016\/j.chom.2014.02.005","journal-title":"Cell Host Microbe"},{"issue":"12","key":"38_CR64","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1093\/ecco-jcc\/jjv147","volume":"9","author":"J Maukonen","year":"2015","unstructured":"Maukonen J, Kolho KL, Paasela M et al (2015) Altered fecal microbiota in paediatric inflammatory Bowel disease. J Crohns Colitis 9(12):1088\u20131095. \n                    https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv147","journal-title":"J Crohns Colitis"},{"key":"38_CR65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cimid.2015.10.005","volume":"43","author":"SF Oyri","year":"2015","unstructured":"Oyri SF, Muzes G, Sipos F (2015) Dysbiotic gut microbiome: a key element of Crohn\u2019s disease. Comp Immunol Microbiol Infect Dis 43:36\u201349. \n                    https:\/\/doi.org\/10.1016\/j.cimid.2015.10.005","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"5","key":"38_CR66","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.tim.2014.01.011","volume":"22","author":"A Shafquat","year":"2014","unstructured":"Shafquat A, Joice R, Simmons SL et al (2014) Functional and phylogenetic assembly of microbial communities in the human microbiome. Trends Microbiol 22(5):261\u2013266. \n                    https:\/\/doi.org\/10.1016\/j.tim.2014.01.011","journal-title":"Trends Microbiol"},{"issue":"2","key":"38_CR67","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/path.1824","volume":"207","author":"I Szanto","year":"2005","unstructured":"Szanto I, Rubbia-Brandt L, Kiss P et al (2005) Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol 207(2):164\u2013176. \n                    https:\/\/doi.org\/10.1002\/path.1824","journal-title":"J Pathol"},{"issue":"23","key":"38_CR68","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1038\/emboj.2013.224","volume":"32","author":"RM Jones","year":"2013","unstructured":"Jones RM, Luo L, Ardita CS et al (2013) Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. EMBO J 32(23):3017\u20133028. \n                    https:\/\/doi.org\/10.1038\/emboj.2013.224","journal-title":"EMBO J"},{"issue":"1","key":"38_CR69","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1172\/jci65831","volume":"123","author":"G Leoni","year":"2013","unstructured":"Leoni G, Alam A, Neumann PA et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123(1):443\u2013454. \n                    https:\/\/doi.org\/10.1172\/jci65831","journal-title":"J Clin Invest"},{"issue":"8","key":"38_CR70","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1172\/jci75436","volume":"124","author":"Y Haberman","year":"2014","unstructured":"Haberman Y, Tickle TL, Dexheimer PJ et al (2014) Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest 124(8):3617\u20133633. \n                    https:\/\/doi.org\/10.1172\/jci75436","journal-title":"J Clin Invest"},{"issue":"4","key":"38_CR71","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1080\/00365520600976266","volume":"42","author":"C Csillag","year":"2007","unstructured":"Csillag C, Nielsen OH, Vainer B et al (2007) Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn\u2019s disease. Scand J Gastroenterol 42(4):454\u2013463. \n                    https:\/\/doi.org\/10.1080\/00365520600976266","journal-title":"Scand J Gastroenterol"},{"issue":"10","key":"38_CR72","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1002\/ibd.21208","volume":"16","author":"CM Hamm","year":"2010","unstructured":"Hamm CM, Reimers MA, McCullough CK et al (2010) NOD2 status and human ileal gene expression. Inflamm Bowel Dis 16(10):1649\u20131657. \n                    https:\/\/doi.org\/10.1002\/ibd.21208","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"38_CR73","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1053\/j.gastro.2016.12.053","volume":"153","author":"M Parlato","year":"2017","unstructured":"Parlato M, Charbit-Henrion F, Hayes P et al (2017) First identification of biallelic inherited DUOX2 inactivating mutations as a cause of very early onset inflammatory Bowel disease. Gastroenterology 153(2):609\u2013611.e603. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2016.12.053","journal-title":"Gastroenterology"},{"issue":"4","key":"38_CR74","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1053\/j.gastro.2016.06.040","volume":"151","author":"AP Levine","year":"2016","unstructured":"Levine AP, Pontikos N, Schiff ER et al (2016) Genetic complexity of Crohn\u2019s disease in two large Ashkenazi Jewish families. Gastroenterology 151(4):698\u2013709. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2016.06.040","journal-title":"Gastroenterology"},{"issue":"3","key":"38_CR75","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/01.MIB.0000442012.45038.0e","volume":"20","author":"TS MacFie","year":"2014","unstructured":"MacFie TS, Poulsom R, Parker A et al (2014) DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm Bowel Dis 20(3):514\u2013524. \n                    https:\/\/doi.org\/10.1097\/01.MIB.0000442012.45038.0e","journal-title":"Inflamm Bowel Dis"},{"issue":"30","key":"38_CR76","doi-asserted-by":"publisher","first-page":"23227","DOI":"10.1074\/jbc.M000916200","volume":"275","author":"X Deken De","year":"2000","unstructured":"De Deken X, Wang D, Many MC et al (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem 275(30):23227\u201323233. \n                    https:\/\/doi.org\/10.1074\/jbc.M000916200","journal-title":"J Biol Chem"},{"issue":"3","key":"38_CR77","doi-asserted-by":"publisher","first-page":"E544","DOI":"10.1210\/jc.2013-3618","volume":"99","author":"M Muzza","year":"2014","unstructured":"Muzza M, Rabbiosi S, Vigone MC et al (2014) The clinical and molecular characterization of patients with dyshormonogenic congenital hypothyroidism reveals specific diagnostic clues for DUOX2 defects. J Clin Endocrinol Metab 99(3):E544\u2013E553. \n                    https:\/\/doi.org\/10.1210\/jc.2013-3618","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"38_CR78","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1210\/jc.2017-00529","volume":"102","author":"Z Aycan","year":"2017","unstructured":"Aycan Z, Cangul H, Muzza M et al (2017) Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism. J Clin Endocrinol Metab 102(9):3085\u20133090. \n                    https:\/\/doi.org\/10.1210\/jc.2017-00529","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"38_CR79","doi-asserted-by":"publisher","first-page":"10158","DOI":"10.1038\/s41598-018-28586-5","volume":"8","author":"H Grasberger","year":"2018","unstructured":"Grasberger H, Noureldin M, Kao TD, Adler J, Lee JM, Bishu S, El-Zaatari M, Kao JY, Waljee AK (2018) Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor. Sci Rep 8(1):10158. \n                    https:\/\/doi.org\/10.1038\/s41598-018-28586-5","journal-title":"Sci Rep"},{"issue":"5749","key":"38_CR80","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1126\/science.1117311","volume":"310","author":"EM Ha","year":"2005","unstructured":"Ha EM, Oh CT, Bae YS et al (2005) A direct role for dual oxidase in Drosophila gut immunity. Science 310(5749):847\u2013850. \n                    https:\/\/doi.org\/10.1126\/science.1117311","journal-title":"Science"},{"key":"38_CR81","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3389\/fcimb.2013.00116","volume":"3","author":"SH Kim","year":"2014","unstructured":"Kim SH, Lee WJ (2014) Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions. Front Cell Infect Microbiol 3:116. \n                    https:\/\/doi.org\/10.3389\/fcimb.2013.00116","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"38_CR82","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1128\/iai.00627-09","volume":"77","author":"V Chavez","year":"2009","unstructured":"Chavez V, Mohri-Shiomi A, Garsin DA (2009) Ce-Duox1\/BLI-3 generates reactive oxygen species as a protective innate immune mechanism in Caenorhabditis elegans. Infect Immun 77(11):4983\u20134989. \n                    https:\/\/doi.org\/10.1128\/iai.00627-09","journal-title":"Infect Immun"},{"issue":"1","key":"38_CR83","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbrc.2010.08.037","volume":"400","author":"MV Flores","year":"2010","unstructured":"Flores MV, Crawford KC, Pullin LM et al (2010) Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochem Biophys Res Commun 400(1):164\u2013168. \n                    https:\/\/doi.org\/10.1016\/j.bbrc.2010.08.037","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"38_CR84","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.chom.2016.04.007","volume":"19","author":"G Pircalabioru","year":"2016","unstructured":"Pircalabioru G, Aviello G, Kubica M et al (2016) Defensive mutualism rescues NADPH oxidase inactivation in gut infection. Cell Host Microbe 19(5):651\u2013663. \n                    https:\/\/doi.org\/10.1016\/j.chom.2016.04.007","journal-title":"Cell Host Microbe"},{"issue":"5","key":"38_CR85","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1053\/j.gastro.2013.07.011","volume":"145","author":"H Grasberger","year":"2013","unstructured":"Grasberger H, El-Zaatari M, Dang DT et al (2013) Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 145(5):1045\u20131054. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2013.07.011","journal-title":"Gastroenterology"},{"issue":"1","key":"38_CR86","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.chom.2012.05.018","volume":"12","author":"N Corcionivoschi","year":"2012","unstructured":"Corcionivoschi N, Alvarez LA, Sharp TH et al (2012) Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe 12(1):47\u201359. \n                    https:\/\/doi.org\/10.1016\/j.chom.2012.05.018","journal-title":"Cell Host Microbe"},{"issue":"9272","key":"38_CR87","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/s0140-6736(00)05063-7","volume":"357","author":"J Hampe","year":"2001","unstructured":"Hampe J, Cuthbert A, Croucher PJ et al (2001) Association between insertion mutation in NOD2 gene and Crohn\u2019s disease in German and British populations. Lancet 357(9272):1925\u20131928. \n                    https:\/\/doi.org\/10.1016\/s0140-6736(00)05063-7","journal-title":"Lancet"},{"issue":"6837","key":"38_CR88","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease. Nature 411(6837):603\u2013606. \n                    https:\/\/doi.org\/10.1038\/35079114","journal-title":"Nature"},{"issue":"6837","key":"38_CR89","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot JP, Chamaillard M, Zouali H et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature 411(6837):599\u2013603. \n                    https:\/\/doi.org\/10.1038\/35079107","journal-title":"Nature"},{"issue":"Pt 19","key":"38_CR90","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1242\/jcs.050690","volume":"122","author":"S Lipinski","year":"2009","unstructured":"Lipinski S, Till A, Sina C et al (2009) DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. J Cell Sci 122(Pt 19):3522\u20133530. \n                    https:\/\/doi.org\/10.1242\/jcs.050690","journal-title":"J Cell Sci"},{"issue":"12","key":"38_CR91","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1007\/s00535-009-0119-6","volume":"44","author":"M Kamizato","year":"2009","unstructured":"Kamizato M, Nishida K, Masuda K et al (2009) Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon. J Gastroenterol 44(12):1172\u20131184. \n                    https:\/\/doi.org\/10.1007\/s00535-009-0119-6","journal-title":"J Gastroenterol"},{"issue":"7","key":"38_CR92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101669","volume":"9","author":"X Treton","year":"2014","unstructured":"Treton X, Pedruzzi E, Guichard C et al (2014) Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PLoS One 9(7):e101669. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0101669","journal-title":"PLoS One"},{"issue":"10075","key":"38_CR93","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/s0140-6736(17)30182-4","volume":"389","author":"S Paramsothy","year":"2017","unstructured":"Paramsothy S, Kamm MA, Kaakoush NO et al (2017) Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389(10075):1218\u20131228. \n                    https:\/\/doi.org\/10.1016\/s0140-6736(17)30182-4","journal-title":"Lancet"},{"issue":"10","key":"38_CR94","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1097\/MIB.0000000000001228","volume":"23","author":"Neeraj Narula","year":"2017","unstructured":"Narula N, Kassam Z, Yuan Y et al (2017) Systematic review and meta-analysis: fecal microbiota transplantation for treatment of active ulcerative colitis. Inflamm Bowel Dis 23(10):1702\u20131709. \n                    https:\/\/doi.org\/10.1097\/mib.0000000000001228","journal-title":"Inflammatory Bowel Diseases"},{"issue":"4","key":"38_CR95","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.gtc.2017.08.005","volume":"46","author":"AS Browne","year":"2017","unstructured":"Browne AS, Kelly CR (2017) Fecal transplant in inflammatory Bowel disease. Gastroenterol Clin North Am 46(4):825\u2013837. \n                    https:\/\/doi.org\/10.1016\/j.gtc.2017.08.005","journal-title":"Gastroenterol Clin North Am"},{"issue":"3","key":"38_CR96","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.crohns.2011.01.006","volume":"5","author":"A Levine","year":"2011","unstructured":"Levine A, Turner D (2011) Combined azithromycin and metronidazole therapy is effective in inducing remission in pediatric Crohn\u2019s disease. J Crohns Colitis 5(3):222\u2013226. \n                    https:\/\/doi.org\/10.1016\/j.crohns.2011.01.006","journal-title":"J Crohns Colitis"},{"issue":"11","key":"38_CR97","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.crohns.2014.05.010","volume":"8","author":"D Turner","year":"2014","unstructured":"Turner D, Levine A, Kolho KL et al (2014) Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: a preliminary report. J Crohns Colitis 8(11):1464\u20131470. \n                    https:\/\/doi.org\/10.1016\/j.crohns.2014.05.010","journal-title":"J Crohns Colitis"},{"issue":"4","key":"38_CR98","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000475660","volume":"95","author":"R Lev-Tzion","year":"2017","unstructured":"Lev-Tzion R, Ledder O, Shteyer E et al (2017) Oral vancomycin and gentamicin for treatment of very early onset inflammatory Bowel disease. Digestion 95(4):310\u2013313. \n                    https:\/\/doi.org\/10.1159\/000475660","journal-title":"Digestion"},{"issue":"2","key":"38_CR99","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1053\/j.gastro.2012.06.025","volume":"143","author":"AM Muise","year":"2012","unstructured":"Muise AM, Snapper SB, Kugathasan S (2012) The age of gene discovery in very early onset inflammatory Bowel disease. Gastroenterology 143(2):285\u2013288. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2012.06.025","journal-title":"Gastroenterology"},{"issue":"9","key":"38_CR100","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tig.2017.06.008","volume":"33","author":"HH Uhlig","year":"2017","unstructured":"Uhlig HH, Muise AM (2017) Clinical genomics in inflammatory Bowel disease. Trends Genet 33(9):629\u2013641. \n                    https:\/\/doi.org\/10.1016\/j.tig.2017.06.008","journal-title":"Trends Genet"},{"issue":"1","key":"38_CR101","doi-asserted-by":"publisher","first-page":"a002428","DOI":"10.1101\/mcs.a002428","volume":"5","author":"Simone Lipinski","year":"2019","unstructured":"Lipinsky S, Petersen BS, Barann M et al (2019) Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2. Cold Spring Harb Mol Case Stud 5:a002428. \n                    https:\/\/doi.org\/10.1101\/mcs.a002428","journal-title":"Molecular Case Studies"}],"updated-by":[{"DOI":"10.1007\/978-1-4939-9424-3_39","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000}}],"container-title":["Methods in Molecular Biology","NADPH Oxidases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-9424-3_38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T05:07:52Z","timestamp":1563858472000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-9424-3_38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9781493994236","9781493994243"],"references-count":101,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-9424-3_38","relation":{"correction":[{"id-type":"doi","id":"10.1007\/978-1-4939-9424-3_39","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"7 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"24 July 2019","order":2,"name":"change_date","label":"Change Date","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"The title of Chapter 38 was published with a typo error. It should read \u201cNADPH Oxidases in Inflammatory Bowel Disease\u201d, whereas the title was mistakenly printed as \u201cNAPDH Oxidases in Inflammatory Bowel Disease\u201d and the book has been updated for this error.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}