{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:47:59Z","timestamp":1774018079546,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":49,"publisher":"Springer New York","isbn-type":[{"value":"9781493995530","type":"print"},{"value":"9781493995547","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-1-4939-9554-7_23","type":"book-chapter","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T14:39:21Z","timestamp":1562251161000},"page":"393-412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An Animal Model to Test Reversal of Cognitive Decline Associated with Beta-Amyloid Pathologies"],"prefix":"10.1007","author":[{"given":"Farah","family":"Deba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman K.","family":"Hamouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"23_CR1","doi-asserted-by":"publisher","first-page":"903","DOI":"10.2174\/156720501209151019111448","volume":"12","author":"P Maresova","year":"2015","unstructured":"Maresova P, Mohelska H, Dolejs J, Kuca K (2015) Socio-economic aspects of Alzheimer\u2019s disease. Curr Alzheimer Res 12:903\u2013911","journal-title":"Curr Alzheimer Res"},{"key":"23_CR2","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.12688\/f1000research.14506.1","volume":"7","author":"J Weller","year":"2008","unstructured":"Weller J, Budson A (2008) Current understanding of Alzheimer\u2019s disease diagnosis and treatment. F1000Res 7:1161","journal-title":"F1000Res"},{"key":"23_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1177\/1756285612461679","volume":"6","author":"KG Yiannopoulou","year":"2013","unstructured":"Yiannopoulou KG, Papageorgiou SG (2013) Current and future treatments for Alzheimer\u2019s disease. Ther Adv Neurol Disord 6:19\u201333","journal-title":"Ther Adv Neurol Disord"},{"key":"23_CR4","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/med.21434","volume":"37","author":"SO Bachurin","year":"2017","unstructured":"Bachurin SO, Bovina EV, Ustyugov AA (2017) Drugs in clinical trials for Alzheimer\u2019s disease: the major trends. Med Res Rev 37:1186\u20131225","journal-title":"Med Res Rev"},{"key":"23_CR5","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nrd3505","volume":"10","author":"E Karran","year":"2011","unstructured":"Karran E, Mercken M, De Strooper B (2011) The amyloid cascade hypothesis for Alzheimer\u2019s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10:698\u2013712","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"23_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131525","volume":"10","author":"L Zhang","year":"2015","unstructured":"Zhang L, Fang Y, Xu Y, Lian Y, Xie N, Wu T, Zhang H, Sun L, Zhang R, Wang Z (2015) Curcumin improves amyloid \u03b2-peptide (1-42) induced spatial memory deficits through BDNF-ERK signaling pathway. PLoS One 10(6):e0131525","journal-title":"PLoS One"},{"key":"23_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/msj.20159","volume":"77","author":"GA Elder","year":"2010","unstructured":"Elder GA, Gama Sosa MA, De Gasperi R (2010) Transgenic mouse models of Alzheimer\u2019s disease. Mt Sinai J Med 77:69\u201381","journal-title":"Mt Sinai J Med"},{"key":"23_CR8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-1-60761-744-0_13","volume":"670","author":"J Chin","year":"2011","unstructured":"Chin J (2011) Selecting a mouse model of Alzheimer\u2019s disease. Methods Mol Biol 670:169\u2013189","journal-title":"Methods Mol Biol"},{"key":"23_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/373523a0","volume":"373","author":"D Games","year":"1995","unstructured":"Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523\u2013527","journal-title":"Nature"},{"key":"23_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.274.5284.99","volume":"274","author":"K Hsiao","year":"1996","unstructured":"Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99\u2013102","journal-title":"Science"},{"key":"23_CR11","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","volume":"20","author":"L Mucke","year":"2000","unstructured":"Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L (2000) High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20:4050\u20134058","journal-title":"J Neurosci"},{"key":"23_CR12","doi-asserted-by":"publisher","first-page":"21562","DOI":"10.1074\/jbc.M100710200","volume":"276","author":"MA Chishti","year":"2001","unstructured":"Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276:21562\u201321570","journal-title":"J Biol Chem"},{"key":"23_CR13","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/nn1302","volume":"7","author":"MC Herzig","year":"2004","unstructured":"Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, St\u00fcrchler-Pierrat C, B\u00fcrki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M (2004) Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci 7:954\u2013960","journal-title":"Nat Neurosci"},{"key":"23_CR14","doi-asserted-by":"publisher","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","volume":"94","author":"C Sturchler-Pierrat","year":"1997","unstructured":"Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, B\u00fcrki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 94:13287\u201313292","journal-title":"Proc Natl Acad Sci U S A"},{"key":"23_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0006-8993(01)02772-X","volume":"914","author":"E Rockenstein","year":"2001","unstructured":"Rockenstein E, Hansen LA, Mallory M, Trojanowski JQ, Galasko D, Masliah E (2001) Altered expression of the synuclein family mRNA in Lewy body and Alzheimer\u2019s disease. Brain Res 914:48\u201356","journal-title":"Brain Res"},{"key":"23_CR16","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1038\/nm1123","volume":"10","author":"IH Cheng","year":"2004","unstructured":"Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 10:1190\u20131192","journal-title":"Nat Med"},{"key":"23_CR17","doi-asserted-by":"publisher","first-page":"23818","DOI":"10.1074\/jbc.M701078200","volume":"282","author":"IH Cheng","year":"2007","unstructured":"Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliv\u00e4li J, Lesn\u00e9 S, Ashe KH, Muchowski PJ, Mucke L (2007) Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 282:23818\u201323828","journal-title":"J Biol Chem"},{"key":"23_CR18","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/383710a0","volume":"383","author":"K Duff","year":"1996","unstructured":"Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-Tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383:710\u2013713","journal-title":"Nature"},{"key":"23_CR19","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nm0797-756","volume":"3","author":"MK Lee","year":"1997","unstructured":"Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS (1997) Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat Med 3:756\u2013760","journal-title":"Nat Med"},{"key":"23_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/78078","volume":"25","author":"J Lewis","year":"2000","unstructured":"Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25:402\u2013405","journal-title":"Nat Genet"},{"key":"23_CR21","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1126\/science.1113694","volume":"309","author":"K Santacruz","year":"2005","unstructured":"Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309:476\u2013481","journal-title":"Science"},{"key":"23_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nm0198-097","volume":"1","author":"L Holcomb","year":"1998","unstructured":"Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O\u2019Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1:97\u2013100","journal-title":"Nat Med"},{"key":"23_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/hmg\/ddh019","volume":"13","author":"JL Jankowskym","year":"2004","unstructured":"Jankowskym JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13:159\u2013170","journal-title":"Hum Mol Genet"},{"key":"23_CR24","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. J Neurosci 26:10129\u201310140","journal-title":"J Neurosci"},{"key":"23_CR25","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1126\/science.1058189","volume":"293","author":"J Lewis","year":"2001","unstructured":"Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293:1487\u20131491","journal-title":"Science"},{"key":"23_CR26","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409\u2013421","journal-title":"Neuron"},{"key":"23_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1750-1326-8-37","volume":"8","author":"S Do Carmo","year":"2013","unstructured":"Do Carmo S, Cuello AC (2013) Modeling Alzheimer\u2019s disease in transgenic rats. Mol Neurodegener 8:37","journal-title":"Mol Neurodegener"},{"key":"23_CR28","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3233\/JAD-2004-6301","volume":"6","author":"V Echeverria","year":"2004","unstructured":"Echeverria V, Ducatenzeiler A, Alhonen L, Janne J, Grant SM, Wandosell F, Muro A, Baralle F, Li H, Duff K, Szyf M, Cuello AC (2004) Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. J Alzheimers Dis 6:209\u2013219","journal-title":"J Alzheimers Dis"},{"key":"23_CR29","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2119\/2003-00044.Herrera","volume":"10","author":"N Ruiz-Opazo","year":"2004","unstructured":"Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL (2004) Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats. Mol Med 10:36\u201344","journal-title":"Mol Med"},{"key":"23_CR30","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.bbrc.2007.04.195","volume":"358","author":"R Folkesson","year":"2007","unstructured":"Folkesson R, Malkiewicz K, Kloskowska E, Nilsson T, Popova E, Bogdanovic N, Ganten U, Ganten D, Bader M, Winblad B, Benedikz E (2007) A transgenic rat expressing human APP with the Swedish Alzheimer\u2019s disease mutation. Biochem Biophys Res Commun 358:777\u2013782","journal-title":"Biochem Biophys Res Commun"},{"key":"23_CR31","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1111\/j.1582-4934.2009.00809.x","volume":"14","author":"E Kloskowska","year":"2010","unstructured":"Kloskowska E, Pham TM, Nilsson T, Zhu S, Oberg J, Codita A, Pedersen LA, Pedersen JT, Malkiewicz K, Winblad B, Folkesson R, Benedikz E (2010) Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer\u2019s disease. J Cell Mol Med 14:1816\u20131823","journal-title":"J Cell Mol Med"},{"key":"23_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3233\/JAD-2010-1349","volume":"20","author":"WC Leon","year":"2010","unstructured":"Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC (2010) A novel transgenic rat model with a full Alzheimer\u2019s-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. J Alzheimers Dis 20:113\u2013126","journal-title":"J Alzheimers Dis"},{"key":"23_CR33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.nbd.2017.08.019","volume":"108","author":"MF Iulita","year":"2017","unstructured":"Iulita MF, Bistu\u00e9 Mill\u00f3n MB, Pentz R, Aguilar LF, Do Carmo S, Allard S, Michalski B, Wilson EN, Ducatenzeiler A, Bruno MA, Fahnestock M, Cuello AC (2017) Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer\u2019s disease. Neurobiol Dis 108:307\u2013323","journal-title":"Neurobiol Dis"},{"key":"23_CR34","doi-asserted-by":"publisher","first-page":"8637","DOI":"10.1007\/s12035-018-1002-3","volume":"55","author":"P Galeano","year":"2018","unstructured":"Galeano P, Leal MC, Ferrari CC, Dalmasso MC, Martino Adami PV, Far\u00edas MI, Casabona JC, Puntel M, Do Carmo S, Smal C, Ar\u00e1n M, Casta\u00f1o EM, Pitossi FJ, Cuello AC, Morelli L (2018) Chronic hippocampal expression of notch intracellular domain induces vascular thickening, reduces glucose availability, and exacerbates spatial memory deficits in a rat model of early Alzheimer. Mol Neurobiol 55:8637\u20138650","journal-title":"Mol Neurobiol"},{"key":"23_CR35","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jalz.2017.11.009","volume":"14","author":"H Hall","year":"2018","unstructured":"Hall H, Iulita MF, Gubert P, Flores Aguilar L, Ducatenzeiler A, Fisher A, Cuello AC (2018) AF710B, an M1\/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer\u2019s disease. Alzheimers Dement 14:811\u2013823","journal-title":"Alzheimers Dement"},{"key":"23_CR36","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.neurobiolaging.2007.10.006","volume":"30","author":"DG Flood","year":"2009","unstructured":"Flood DG, Lin YG, Lang DM, Trusko SP, Hirsch JD, Savage MJ, Scott RW, Howland DS (2009) A transgenic rat model of Alzheimer\u2019s disease with extracellular Abeta deposition. A transgenic rat model of Alzheimer\u2019s disease with extracellular Abeta deposition. Neurobiol Aging 30:1078\u20131090","journal-title":"Neurobiol Aging"},{"key":"23_CR37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.nbd.2008.03.005","volume":"31","author":"L Liu","year":"2008","unstructured":"Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K (2008) A transgenic rat that develops Alzheimer\u2019s disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiol Dis 31:46\u201357","journal-title":"Neurobiol Dis"},{"key":"23_CR38","doi-asserted-by":"publisher","first-page":"6245","DOI":"10.1523\/JNEUROSCI.3672-12.2013","volume":"33","author":"RM Cohen","year":"2013","unstructured":"Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T (2013) A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric a\u03b2, and frank neuronal loss. J Neurosci 33:6245\u20136256","journal-title":"J Neurosci"},{"key":"23_CR39","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.neurobiolaging.2010.10.015","volume":"33","author":"P Filipcik","year":"2012","unstructured":"Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M (2012) First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging 33:1448\u20131456","journal-title":"Neurobiol Aging"},{"key":"23_CR40","first-page":"368","volume":"32","author":"WG Hilliard","year":"1968","unstructured":"Hilliard WG, Dillistone EJ, Oliver WT (1968) A method for cerebroventricular cannulation of the rat. Can J Comp Med Vet Sci 32:368\u2013371","journal-title":"Can J Comp Med Vet Sci"},{"key":"23_CR41","volume-title":"The rat brain in stereotaxic coordinates \u2013 the new coronal set","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Watson C (2004) The rat brain in stereotaxic coordinates \u2013 the new coronal set, 5th edn. Academic Press, New York","edition":"5"},{"key":"23_CR42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-60761-744-0_2","volume":"670","author":"WB Stine","year":"2011","unstructured":"Stine WB, Jungbauer L, Yu C, LaDu MJ (2011) Preparing synthetic A\u03b2 in different aggregation states. Methods Mol Biol 670:13\u201332","journal-title":"Methods Mol Biol"},{"key":"23_CR43","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/j.1476-5381.2010.00669.x","volume":"159","author":"M Colaianna","year":"2010","unstructured":"Colaianna M, Tucci P, Zotti M, Morgese MG, Schiavone S, Govoni S, Cuomo V, Trabace L (2010) Soluble beta amyloid(1\u201342): a critical player in producing behavioural and biochemical changes evoking depressive-related state? Br J Pharmacol 159:1704\u20131715","journal-title":"Br J Pharmacol"},{"key":"23_CR44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","volume":"189","author":"H Shiotsuki","year":"2010","unstructured":"Shiotsuki H, Yoshimi K, Shimo Y, Funayama M, Takamatsu Y, Ikeda K, Takahashi R, Kitazawa S, Hattori N (2010) A rotarod test for evaluation of motor skill learning. J Neurosci Methods 189:180\u2013185","journal-title":"J Neurosci Methods"},{"key":"23_CR45","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1037\/0735-7044.98.6.946","volume":"98","author":"LE Jarrard","year":"1984","unstructured":"Jarrard LE, Okaichi H, Steward O, Goldschmidt RB (1984) On the role of hippocampal connections in the performance of place and cue tasks: comparisons with damage to hippocampus. Behav Neurosci 98:946\u2013954","journal-title":"Behav Neurosci"},{"key":"23_CR46","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuroscience.2015.08.015","volume":"305","author":"A Ahmadalipour","year":"2015","unstructured":"Ahmadalipour A, Sadeghzadeh J, Vafaei AA, Bandegi AR, Mohammadkhani R, Rashidy-Pour A (2015) Effects of environmental enrichment on behavioral deficits and alterations in hippocampal BDNF induced by prenatal exposure to morphine in juvenile rats. Neuroscience 305:372\u2013383","journal-title":"Neuroscience"},{"key":"23_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"R Morris","year":"1984","unstructured":"Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47\u201360","journal-title":"J Neurosci Methods"},{"key":"23_CR48","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848\u2013858","journal-title":"Nat Protoc"},{"key":"23_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029661","volume":"7","author":"E Mura","year":"2012","unstructured":"Mura E, Zappettini S, Preda S, Biundo F, Lanni C, Grilli M, Cavallero A, Olivero G, Salamone A, Govoni S, Marchi M (2012) Dual effect of beta-amyloid on \u03b17 and \u03b14\u03b22 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus. PLoS One 7:e29661","journal-title":"PLoS One"}],"container-title":["Methods in Molecular Biology","Psychiatric Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-9554-7_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T17:06:36Z","timestamp":1649955996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-9554-7_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9781493995530","9781493995547"],"references-count":49,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-9554-7_23","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"5 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}