{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:00:44Z","timestamp":1786978844222,"version":"build-2736575974"},"publisher-location":"New York, NY","reference-count":22,"publisher":"Springer New York","isbn-type":[{"value":"9781493996384","type":"print"},{"value":"9781493996391","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-1-4939-9639-1_16","type":"book-chapter","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:02:52Z","timestamp":1564059772000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Methods for Absolute Quantification of Human Plasma Free Amino Acids by High-Performance Liquid Chromatography\/Electrospray Ionization Mass Spectrometry Using Precolumn Derivatization"],"prefix":"10.1007","author":[{"given":"Akira","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"issue":"9","key":"16_CR1","doi-asserted-by":"publisher","first-page":"e0185206","DOI":"10.1371\/journal.pone.0185206","volume":"12","author":"K Toyoshima","year":"2017","unstructured":"Toyoshima K, Nakamura M et al (2017) Increased plasma proline concentrations are associated with sarcopenia in the elderly. PLoS One. 12(9):e0185206. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0185206","journal-title":"PLoS One."},{"issue":"2","key":"16_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1139\/apnm-2013-0244","volume":"39","author":"M Moberg","year":"2014","unstructured":"Moberg M, Apr\u00f3 W et al (2014) Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females. Appl Physiol Nutr Metab 39(2):183\u2013194. \nhttps:\/\/doi.org\/10.1139\/apnm-2013-0244","journal-title":"Appl Physiol Nutr Metab"},{"issue":"6","key":"16_CR3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.molmed.2013.02.007","volume":"19","author":"AT Goot van der","year":"2013","unstructured":"van der Goot AT, Nollen EA (2013) Tryptophan metabolism: entering the field of aging and age-related pathologies. Trends Mol Med 19(6):336\u2013344. \nhttps:\/\/doi.org\/10.1016\/j.molmed.2013.02.007","journal-title":"Trends Mol Med"},{"issue":"1","key":"16_CR4","doi-asserted-by":"publisher","first-page":"14485","DOI":"10.1038\/s41598-017-14974-w","volume":"7","author":"M Yamakado","year":"2017","unstructured":"Yamakado M, Tanaka T et al (2017) Plasma amino acid profile associated with fatty liver disease and co-occurrence of metabolic risk factors. Sci Rep 7(1):14485. \nhttps:\/\/doi.org\/10.1038\/s41598-017-14974-w","journal-title":"Sci Rep"},{"issue":"7","key":"16_CR5","doi-asserted-by":"publisher","first-page":"e0132223","DOI":"10.1371\/journal.pone.0132223","volume":"10","author":"N Fukutake","year":"2015","unstructured":"Fukutake N, Ueno M et al (2015) A novel multivariate index for pancreatic cancer detection based on the plasma free amino acid profile. PLoS One 10(7):e0132223. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0132223","journal-title":"PLoS One"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"11918","DOI":"10.1038\/srep11918","volume":"5","author":"M Yamakado","year":"2015","unstructured":"Yamakado M, Nagao K et al (2015) Plasma free amino acid profiles predict four-year risk of developing diabetes, metabolic syndrome, dyslipidemia, and hypertension in Japanese population. Sci Rep 5:11918. \nhttps:\/\/doi.org\/10.1038\/srep11918","journal-title":"Sci Rep"},{"issue":"2","key":"16_CR7","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s10147-013-0565-2","volume":"19","author":"Y Ihata","year":"2014","unstructured":"Ihata Y, Miyagi E et al (2014) Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker. Int J Clin Oncol 19(2):364\u2013372. \nhttps:\/\/doi.org\/10.1007\/s10147-013-0565-2","journal-title":"Int J Clin Oncol"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2407-13-77","volume":"13","author":"M Shingyoji","year":"2013","unstructured":"Shingyoji M, Iizasa T et al (2013) The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer. BMC Cancer 13:77. \nhttps:\/\/doi.org\/10.1186\/1471-2407-13-77","journal-title":"BMC Cancer"},{"issue":"9","key":"16_CR9","doi-asserted-by":"publisher","first-page":"e24143","DOI":"10.1371\/journal.pone.0024143","volume":"6","author":"Y Miyagi","year":"2011","unstructured":"Miyagi Y, Higashiyama M et al (2011) Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One 6(9):e24143. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0024143","journal-title":"PLoS One"},{"key":"16_CR10","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1186\/1471-2407-10-690","volume":"10","author":"J Maeda","year":"2010","unstructured":"Maeda J, Higashiyama M et al (2010) Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Cancer 10:690. \nhttps:\/\/doi.org\/10.1186\/1471-2407-10-690","journal-title":"BMC Cancer"},{"key":"16_CR11","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1002\/rcm.4026","volume":"23","author":"K Shimbo","year":"2009","unstructured":"Shimbo K, Oonuki T et al (2009) Precolumn derivatization reagents for high-speed analysis of amines and amino acids in biological fluid using liquid chromatography\/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 23:1483\u20131492. \nhttps:\/\/doi.org\/10.1002\/rcm.4026","journal-title":"Rapid Commun Mass Spectrom"},{"key":"16_CR12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1002\/bmc.1346","volume":"24","author":"K Shimbo","year":"2009","unstructured":"Shimbo K, Kubo S et al (2009) Automated precolumn derivatization system for analyzing physiological amino acids by liquid chromatography\/mass spectrometry. Biomed Chromatogr 24:683\u2013691. \nhttps:\/\/doi.org\/10.1002\/bmc.1346","journal-title":"Biomed Chromatogr"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jchromb.2015.05.029","volume":"998\u2013999","author":"H Yoshida","year":"2015","unstructured":"Yoshida H, Kondo K et al (2015) Validation of an analytical method for human plasma free amino acids by high-performance liquid chromatography ionization mass spectrometry using automated precolumn derivatization. J Chromatogr B 998\u2013999:88\u201396. \nhttps:\/\/doi.org\/10.1016\/j.jchromb.2015.05.029","journal-title":"J Chromatogr B"},{"issue":"Pt 3","key":"16_CR14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/0004563215583360","volume":"53","author":"H Yamamoto","year":"2016","unstructured":"Yamamoto H, Kondo K et al (2016) Reference intervals for plasma-free amino acid in a Japanese population. Ann Clin Biochem 53(Pt 3):357\u2013364. \nhttps:\/\/doi.org\/10.1177\/0004563215583360","journal-title":"Ann Clin Biochem"},{"key":"16_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cca.2016.01.026","volume":"455","author":"S Takehana","year":"2016","unstructured":"Takehana S, Yoshida H et al (2016) The effects of pre-analysis sample handling on human plasma amino acid concentrations. Clin Chim Acta 455:68\u201374. \nhttps:\/\/doi.org\/10.1016\/j.cca.2016.01.026","journal-title":"Clin Chim Acta"},{"issue":"2","key":"16_CR16","first-page":"149","volume":"40","author":"Y Yamamoto","year":"2011","unstructured":"Yamamoto Y, Hosogaya S et al (2011) Jpn J Clin Chem 40(2):149\u2013157","journal-title":"Jpn J Clin Chem"},{"key":"16_CR17","unstructured":"ISO 5725: 1994. Accuracy (trueness and precision) of measurement methods and results"},{"key":"16_CR18","unstructured":"Clinical and Laboratory Standards Institute (2003) Evaluation of the linearity of quantitative measurement procedures: A statistical approach; Approved Guideline (EP06-A)"},{"key":"16_CR19","unstructured":"Clinical and Laboratory Standards Institute (2002) Method comparison and bias estimation using patient samples; approved guideline. 2nd edn (EP9-A2)"},{"key":"16_CR20","unstructured":"Clinical and Laboratory Standards Institute (2004) Evaluation of precision performance of quantitative measurement methods; approved guideline. 2nd edn (EP5-A2)"},{"key":"16_CR21","unstructured":"Clinical and Laboratory Standards Institute(2004) Protocols for determination of limits of detection and limits of quantitation; Approved guideline (EP17-A)"},{"key":"16_CR22","unstructured":"Bioanalytical Method Validation Guidance for Industry (2018) \nhttps:\/\/www.fda.gov\/downloads\/Drugs\/Guidances\/ucm070107.pdf"}],"container-title":["Methods in Molecular Biology","Amino Acid Analysis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-9639-1_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:03:19Z","timestamp":1564059799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-9639-1_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9781493996384","9781493996391"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-9639-1_16","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"26 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}