{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:53:38Z","timestamp":1778169218838,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":145,"publisher":"Springer New York","isbn-type":[{"value":"9781493997725","type":"print"},{"value":"9781493997732","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-1-4939-9773-2_15","type":"book-chapter","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T10:03:02Z","timestamp":1568023382000},"page":"325-350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["HLA Class I Antigen Processing Machinery Defects in Cancer Cells\u2014Frequency, Functional Significance, and Clinical Relevance with Special Emphasis on Their Role in T Cell-Based Immunotherapy of Malignant Disease"],"prefix":"10.1007","author":[{"given":"Barbara","family":"Seliger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soldano","family":"Ferrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"issue":"1","key":"15_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/imm.12675","volume":"150","author":"E Reeves","year":"2017","unstructured":"Reeves E, James E (2017) Antigen processing and immune regulation in the response to tumours. Immunology 150(1):16\u201324. https:\/\/doi.org\/10.1111\/imm.12675","journal-title":"Immunology"},{"issue":"6","key":"15_CR2","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00262-018-2131-2","volume":"67","author":"L Cai","year":"2018","unstructured":"Cai L, Michelakos T, Yamada T, Fan S, Wang X, Schwab JH, Ferrone CR, Ferrone S (2018) Defective HLA class I antigen processing machinery in cancer. Cancer Immunol Immunother 67(6):999\u20131009. https:\/\/doi.org\/10.1007\/s00262-018-2131-2","journal-title":"Cancer Immunol Immunother"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.drup.2017.02.001","volume":"30","author":"Y Diesendruck","year":"2017","unstructured":"Diesendruck Y, Benhar I (2017) Novel immune check point inhibiting antibodies in cancer therapy-opportunities and challenges. Drug Resist Updat 30:39\u201347. https:\/\/doi.org\/10.1016\/j.drup.2017.02.001","journal-title":"Drug Resist Updat"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.coi.2014.01.002","volume":"27","author":"JL Perez-Gracia","year":"2014","unstructured":"Perez-Gracia JL, Labiano S, Rodriguez-Ruiz ME, Sanmamed MF, Melero I (2014) Orchestrating immune check-point blockade for cancer immunotherapy in combinations. Curr Opin Immunol 27:89\u201397. https:\/\/doi.org\/10.1016\/j.coi.2014.01.002","journal-title":"Curr Opin Immunol"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ejca.2017.01.035","volume":"81","author":"LA Emens","year":"2017","unstructured":"Emens LA, Ascierto PA, Darcy PK, Demaria S, Eggermont AMM, Redmond WL, Seliger B, Marincola FM (2017) Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape. Eur J Cancer 81:116\u2013129. https:\/\/doi.org\/10.1016\/j.ejca.2017.01.035","journal-title":"Eur J Cancer"},{"key":"15_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00229","volume":"8","author":"E Wennerberg","year":"2017","unstructured":"Wennerberg E, Lhuillier C, Vanpouille-Box C, Pilones KA, Garcia-Martinez E, Rudqvist NP, Formenti SC, Demaria S (2017) Barriers to radiation-induced in situ tumor vaccination. Front Immunol 8:229. https:\/\/doi.org\/10.3389\/fimmu.2017.00229","journal-title":"Front Immunol"},{"issue":"16","key":"15_CR7","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/jnci\/djt184","volume":"105","author":"P Leone","year":"2013","unstructured":"Leone P, Shin EC, Perosa F, Vacca A, Dammacco F, Racanelli V (2013) MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells. J Natl Cancer Inst 105(16):1172\u20131187. https:\/\/doi.org\/10.1093\/jnci\/djt184","journal-title":"J Natl Cancer Inst"},{"issue":"6345","key":"15_CR8","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/353662a0","volume":"353","author":"V Ortiz-Navarrete","year":"1991","unstructured":"Ortiz-Navarrete V, Seelig A, Gernold M, Frentzel S, Kloetzel PM, Hammerling GJ (1991) Subunit of the \u201820S\u2019 proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 353(6345):662\u2013664. https:\/\/doi.org\/10.1038\/353662a0","journal-title":"Nature"},{"issue":"6345","key":"15_CR9","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/353667a0","volume":"353","author":"A Kelly","year":"1991","unstructured":"Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (1991) Second proteasome-related gene in the human MHC class II region. Nature 353(6345):667\u2013668. https:\/\/doi.org\/10.1038\/353667a0","journal-title":"Nature"},{"issue":"5122","key":"15_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1126\/science.8342042","volume":"261","author":"JJ Neefjes","year":"1993","unstructured":"Neefjes JJ, Momburg F, Hammerling GJ (1993) Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261(5122):769\u2013771","journal-title":"Science"},{"issue":"7681","key":"15_CR11","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature24627","volume":"551","author":"A Blees","year":"2017","unstructured":"Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A, Tampe R (2017) Structure of the human MHC-I peptide-loading complex. Nature 551(7681):525\u2013528. https:\/\/doi.org\/10.1038\/nature24627","journal-title":"Nature"},{"issue":"7","key":"15_CR12","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1002\/j.1460-2075.1996.tb00493.x","volume":"15","author":"A Vassilakos","year":"1996","unstructured":"Vassilakos A, Cohen-Doyle MF, Peterson PA, Jackson MR, Williams DB (1996) The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules. EMBO J 15(7):1495\u20131506","journal-title":"EMBO J"},{"issue":"5","key":"15_CR13","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.4049\/jimmunol.1302637","volume":"192","author":"RM Leonhardt","year":"2014","unstructured":"Leonhardt RM, Abrahimi P, Mitchell SM, Cresswell P (2014) Three tapasin docking sites in TAP cooperate to facilitate transporter stabilization and heterodimerization. J Immunol 192(5):2480\u20132494. https:\/\/doi.org\/10.4049\/jimmunol.1302637","journal-title":"J Immunol"},{"issue":"2","key":"15_CR14","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.4049\/jimmunol.166.2.1016","volume":"166","author":"AW Purcell","year":"2001","unstructured":"Purcell AW, Gorman JJ, Garcia-Peydro M, Paradela A, Burrows SR, Talbo GH, Laham N, Peh CA, Reynolds EC, Lopez De Castro JA, McCluskey J (2001) Quantitative and qualitative influences of tapasin on the class I peptide repertoire. J Immunol 166(2):1016\u20131027","journal-title":"J Immunol"},{"issue":"4","key":"15_CR15","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.4049\/jimmunol.1301043","volume":"191","author":"T Kanaseki","year":"2013","unstructured":"Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L, Sato N, Delgado JC, Shastri N (2013) ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol 191(4):1547\u20131555. https:\/\/doi.org\/10.4049\/jimmunol.1301043","journal-title":"J Immunol"},{"key":"15_CR16","doi-asserted-by":"publisher","unstructured":"Eichmuller SB, Osen W, Mandelboim O, Seliger B (2017) Immune modulatory microRNAs involved in tumor attack and tumor immune escape. J Natl Cancer Inst 109(10). https:\/\/doi.org\/10.1093\/jnci\/djx034","DOI":"10.1093\/jnci\/djx034"},{"issue":"12","key":"15_CR17","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.4049\/jimmunol.1501550","volume":"196","author":"A Reches","year":"2016","unstructured":"Reches A, Nachmani D, Berhani O, Duev-Cohen A, Shreibman D, Ophir Y, Seliger B, Mandelboim O (2016) HNRNPR regulates the expression of classical and nonclassical MHC class I proteins. J Immunol 196(12):4967\u20134976. https:\/\/doi.org\/10.4049\/jimmunol.1501550","journal-title":"J Immunol"},{"issue":"14","key":"15_CR18","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1158\/1078-0432.CCR-17-2483","volume":"24","author":"L Huang","year":"2018","unstructured":"Huang L, Malu S, McKenzie JA, Andrews MC, Talukder AH, Tieu T, Karpinets T, Haymaker C, Forget MA, Williams LJ, Wang Z, Mbofung RM, Wang ZQ, Davis RE, Lo RS, Wargo JA, Davies MA, Bernatchez C, Heffernan T, Amaria RN, Korkut A, Peng W, Roszik J, Lizee G, Woodman SE, Hwu P (2018) The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression. Clin Cancer Res 24(14):3366\u20133376. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-2483","journal-title":"Clin Cancer Res"},{"issue":"1","key":"15_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1399-0039.1996.tb02603.x","volume":"48","author":"DJ Hicklin","year":"1996","unstructured":"Hicklin DJ, Kageshita T, Ferrone S (1996) Development and characterization of rabbit antisera to human MHC-linked transporters associated with antigen processing. Tissue Antigens 48(1):38\u201346","journal-title":"Tissue Antigens"},{"issue":"3","key":"15_CR20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1399-0039.2005.00462.x","volume":"66","author":"N Bandoh","year":"2005","unstructured":"Bandoh N, Ogino T, Cho HS, Hur SY, Shen J, Wang X, Kato S, Miyokawa N, Harabuchi Y, Ferrone S (2005) Development and characterization of human constitutive proteasome and immunoproteasome subunit-specific monoclonal antibodies. Tissue Antigens 66(3):185\u2013194. https:\/\/doi.org\/10.1111\/j.1399-0039.2005.00462.x","journal-title":"Tissue Antigens"},{"issue":"5","key":"15_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1034\/j.1399-0039.2003.00114.x","volume":"62","author":"T Ogino","year":"2003","unstructured":"Ogino T, Wang X, Kato S, Miyokawa N, Harabuchi Y, Ferrone S (2003) Endoplasmic reticulum chaperone-specific monoclonal antibodies for flow cytometry and immunohistochemical staining. Tissue Antigens 62(5):385\u2013393","journal-title":"Tissue Antigens"},{"issue":"7","key":"15_CR22","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.4049\/jimmunol.137.7.2299","volume":"137","author":"NJ Stam","year":"1986","unstructured":"Stam NJ, Spits H, Ploegh HL (1986) Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol 137(7):2299\u20132306","journal-title":"J Immunol"},{"issue":"7","key":"15_CR23","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/eji.1830090709","volume":"9","author":"FM Brodsky","year":"1979","unstructured":"Brodsky FM, Bodmer WF, Parham P (1979) Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol 9(7):536\u2013545. https:\/\/doi.org\/10.1002\/eji.1830090709","journal-title":"Eur J Immunol"},{"issue":"1","key":"15_CR24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.123.1.342","volume":"123","author":"P Parham","year":"1979","unstructured":"Parham P, Barnstable CJ, Bodmer WF (1979) Use of a monoclonal antibody (W6\/32) in structural studies of HLA-A,B,C, antigens. J Immunol 123(1):342\u2013349","journal-title":"J Immunol"},{"key":"15_CR25","doi-asserted-by":"publisher","unstructured":"Feng Z, Bethmann D, Kappler M, Ballesteros-Merino C, Eckert A, Bell RB, Cheng A, Bui T, Leidner R, Urba WJ, Johnson K, Hoyt C, Bifulco CB, Bukur J, Wickenhauser C, Seliger B, Fox BA (2017) Multiparametric immune profiling in HPV- oral squamous cell cancer. JCI Insight 2(14). https:\/\/doi.org\/10.1172\/jci.insight.93652","DOI":"10.1172\/jci.insight.93652"},{"issue":"6","key":"15_CR26","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.micinf.2011.12.007","volume":"14","author":"TB Meissner","year":"2012","unstructured":"Meissner TB, Li A, Kobayashi KS (2012) NLRC5: a newly discovered MHC class I transactivator (CITA). Microbes Infect 14(6):477\u2013484. https:\/\/doi.org\/10.1016\/j.micinf.2011.12.007","journal-title":"Microbes Infect"},{"issue":"31","key":"15_CR27","doi-asserted-by":"publisher","first-page":"13794","DOI":"10.1073\/pnas.1008684107","volume":"107","author":"TB Meissner","year":"2010","unstructured":"Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS (2010) NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A 107(31):13794\u201313799. https:\/\/doi.org\/10.1073\/pnas.1008684107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"15_CR28","doi-asserted-by":"publisher","first-page":"5999","DOI":"10.1073\/pnas.1602069113","volume":"113","author":"S Yoshihama","year":"2016","unstructured":"Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, Sidiq T, Shipp MA, Lizee GA, Kobayashi KS (2016) NLRC5\/MHC class I transactivator is a target for immune evasion in cancer. Proc Natl Acad Sci U S A 113(21):5999\u20136004. https:\/\/doi.org\/10.1073\/pnas.1602069113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"15_CR29","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.humimm.2005.10.011","volume":"66","author":"CF Vermeulen","year":"2005","unstructured":"Vermeulen CF, Jordanova ES, Zomerdijk-Nooijen YA, ter Haar NT, Peters AA, Fleuren GJ (2005) Frequent HLA class I loss is an early event in cervical carcinogenesis. Hum Immunol 66(11):1167\u20131173. https:\/\/doi.org\/10.1016\/j.humimm.2005.10.011","journal-title":"Hum Immunol"},{"issue":"7","key":"15_CR30","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.4161\/onci.21056","volume":"1","author":"M Inoue","year":"2012","unstructured":"Inoue M, Mimura K, Izawa S, Shiraishi K, Inoue A, Shiba S, Watanabe M, Maruyama T, Kawaguchi Y, Inoue S, Kawasaki T, Choudhury A, Katoh R, Fujii H, Kiessling R, Kono K (2012) Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression. Oncoimmunology 1(7):1104\u20131110. https:\/\/doi.org\/10.4161\/onci.21056","journal-title":"Oncoimmunology"},{"issue":"5","key":"15_CR31","first-page":"2123","volume":"33","author":"T Hanagiri","year":"2013","unstructured":"Hanagiri T, Shigematsu Y, Shinohara S, Takenaka M, Oka S, Chikaishi Y, Nagata Y, Baba T, Uramoto H, So T, Yamada S (2013) Clinical significance of expression of cancer\/testis antigen and down-regulation of HLA class-I in patients with stage I non-small cell lung cancer. Anticancer Res 33(5):2123\u20132128","journal-title":"Anticancer Res"},{"issue":"6","key":"15_CR32","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.cell.2017.10.001","volume":"171","author":"N McGranahan","year":"2017","unstructured":"McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birkbak NJ, Veeriah S, Van Loo P, Herrero J, Swanton C, Consortium TR (2017) Allele-specific HLA loss and immune escape in lung cancer evolution. Cell 171(6):1259\u20131271 e1211. https:\/\/doi.org\/10.1016\/j.cell.2017.10.001","journal-title":"Cell"},{"issue":"4","key":"15_CR33","first-page":"641","volume":"2","author":"MJ Maeurer","year":"1996","unstructured":"Maeurer MJ, Gollin SM, Storkus WJ, Swaney W, Karbach J, Martin D, Castelli C, Salter R, Knuth A, Lotze MT (1996) Tumor escape from immune recognition: loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6. Clin Cancer Res 2(4):641\u2013652","journal-title":"Clin Cancer Res"},{"issue":"24","key":"15_CR34","first-page":"8647","volume":"61","author":"B Seliger","year":"2001","unstructured":"Seliger B, Ritz U, Abele R, Bock M, Tampe R, Sutter G, Drexler I, Huber C, Ferrone S (2001) Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway. Cancer Res 61(24):8647\u20138650","journal-title":"Cancer Res"},{"issue":"8","key":"15_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006866","volume":"13","author":"PJ Leo","year":"2017","unstructured":"Leo PJ, Madeleine MM, Wang S, Schwartz SM, Newell F, Pettersson-Kymmer U, Hemminki K, Hallmans G, Tiews S, Steinberg W, Rader JS, Castro F, Safaeian M, Franco EL, Coutlee F, Ohlsson C, Cortes A, Marshall M, Mukhopadhyay P, Cremin K, Johnson LG, Trimble CL, Garland S, Tabrizi SN, Wentzensen N, Sitas F, Little J, Cruickshank M, Frazer IH, Hildesheim A, Brown MA (2017) Defining the genetic susceptibility to cervical neoplasia-a genome-wide association study. PLoS Genet 13(8):e1006866. https:\/\/doi.org\/10.1371\/journal.pgen.1006866","journal-title":"PLoS Genet"},{"issue":"11","key":"15_CR36","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1002\/ijc.30681","volume":"140","author":"D Das Ghosh","year":"2017","unstructured":"Das Ghosh D, Mukhopadhyay I, Bhattacharya A, Roy Chowdhury R, Mandal NR, Roy S, Sengupta S (2017) Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis. Int J Cancer 140(11):2498\u20132508. https:\/\/doi.org\/10.1002\/ijc.30681","journal-title":"Int J Cancer"},{"key":"15_CR37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-1-4939-8751-1_11","volume":"1856","author":"ID Florea","year":"2018","unstructured":"Florea ID, Karaoulani C (2018) Epigenetic changes of the immune system with role in tumor development. Methods Mol Biol 1856:203\u2013218. https:\/\/doi.org\/10.1007\/978-1-4939-8751-1_11","journal-title":"Methods Mol Biol"},{"issue":"3","key":"15_CR38","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/00000421-199306000-00012","volume":"16","author":"RG Sheehan","year":"1993","unstructured":"Sheehan RG, Balaban EP, Frenkel EP (1993) The impact of dose intensity of standard chemotherapy regimens in extensive stage small cell lung cancer. Am J Clin Oncol 16(3):250\u2013255","journal-title":"Am J Clin Oncol"},{"issue":"8","key":"15_CR39","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1007\/s00262-010-0856-7","volume":"59","author":"E Kamphausen","year":"2010","unstructured":"Kamphausen E, Kellert C, Abbas T, Akkad N, Tenzer S, Pawelec G, Schild H, van Endert P, Seliger B (2010) Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma. Cancer Immunol Immunother 59(8):1273\u20131284. https:\/\/doi.org\/10.1007\/s00262-010-0856-7","journal-title":"Cancer Immunol Immunother"},{"issue":"11","key":"15_CR40","doi-asserted-by":"publisher","first-page":"5839","DOI":"10.4049\/jimmunol.1300220","volume":"190","author":"E James","year":"2013","unstructured":"James E, Bailey I, Sugiyarto G, Elliott T (2013) Induction of protective antitumor immunity through attenuation of ERAAP function. J Immunol 190(11):5839\u20135846. https:\/\/doi.org\/10.4049\/jimmunol.1300220","journal-title":"J Immunol"},{"issue":"1","key":"15_CR41","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1084\/jem.179.1.335","volume":"179","author":"FV Cromme","year":"1994","unstructured":"Cromme FV, Airey J, Heemels MT, Ploegh HL, Keating PJ, Stern PL, Meijer CJ, Walboomers JM (1994) Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp Med 179(1):335\u2013340","journal-title":"J Exp Med"},{"issue":"8","key":"15_CR42","first-page":"1427","volume":"2","author":"B Seliger","year":"1996","unstructured":"Seliger B, Hohne A, Knuth A, Bernhard H, Ehring B, Tampe R, Huber C (1996) Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. Clin Cancer Res 2(8):1427\u20131433","journal-title":"Clin Cancer Res"},{"issue":"5","key":"15_CR43","first-page":"1721","volume":"9","author":"B Seliger","year":"2003","unstructured":"Seliger B, Atkins D, Bock M, Ritz U, Ferrone S, Huber C, Storkel S (2003) Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation. Clin Cancer Res 9(5):1721\u20131727","journal-title":"Clin Cancer Res"},{"issue":"6","key":"15_CR44","first-page":"1211","volume":"19","author":"U Ritz","year":"2001","unstructured":"Ritz U, Momburg F, Pilch H, Huber C, Maeurer MJ, Seliger B (2001) Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma. Int J Oncol 19(6):1211\u20131220","journal-title":"Int J Oncol"},{"issue":"11","key":"15_CR45","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1356143","volume":"6","author":"A Ling","year":"2017","unstructured":"Ling A, Lofgren-Burstrom A, Larsson P, Li X, Wikberg ML, Oberg A, Stenling R, Edin S, Palmqvist R (2017) TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer. Oncoimmunology 6(11):e1356143. https:\/\/doi.org\/10.1080\/2162402X.2017.1356143","journal-title":"Oncoimmunology"},{"issue":"3","key":"15_CR46","first-page":"505","volume":"145","author":"L Kaklamanis","year":"1994","unstructured":"Kaklamanis L, Townsend A, Doussis-Anagnostopoulou IA, Mortensen N, Harris AL, Gatter KC (1994) Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer. Am J Pathol 145(3):505\u2013509","journal-title":"Am J Pathol"},{"issue":"26","key":"15_CR47","doi-asserted-by":"publisher","first-page":"12716","DOI":"10.1073\/pnas.91.26.12716","volume":"91","author":"MJ Androlewicz","year":"1994","unstructured":"Androlewicz MJ, Ortmann B, van Endert PM, Spies T, Cresswell P (1994) Characteristics of peptide and major histocompatibility complex class I\/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). Proc Natl Acad Sci U S A 91(26):12716\u201312720","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"15_CR48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(SICI)1097-0215(19990331)81:1<125::AID-IJC21>3.0.CO;2-2","volume":"81","author":"M Kallfelz","year":"1999","unstructured":"Kallfelz M, Jung D, Hilmes C, Knuth A, Jaeger E, Huber C, Seliger B (1999) Induction of immunogenicity of a human renal-cell carcinoma cell line by TAP1-gene transfer. Int J Cancer 81(1):125\u2013133","journal-title":"Int J Cancer"},{"issue":"4","key":"15_CR49","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S1074-7613(02)00304-7","volume":"16","author":"AP Williams","year":"2002","unstructured":"Williams AP, Peh CA, Purcell AW, McCluskey J, Elliott T (2002) Optimization of the MHC class I peptide cargo is dependent on tapasin. Immunity 16(4):509\u2013520","journal-title":"Immunity"},{"issue":"2","key":"15_CR50","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1274476","volume":"6","author":"Y Shionoya","year":"2017","unstructured":"Shionoya Y, Kanaseki T, Miyamoto S, Tokita S, Hongo A, Kikuchi Y, Kochin V, Watanabe K, Horibe R, Saijo H, Tsukahara T, Hirohashi Y, Takahashi H, Sato N, Torigoe T (2017) Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition. Oncoimmunology 6(2):e1274476. https:\/\/doi.org\/10.1080\/2162402X.2016.1274476","journal-title":"Oncoimmunology"},{"issue":"1","key":"15_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0021-9673(00)91214-7","volume":"110","author":"DJ Harvey","year":"1975","unstructured":"Harvey DJ (1975) Examination of the diphenylpropanoids of nutmeg as their trimethylsilyl, triethylsilyl and tri-n-propylsilyl derivatives using combined gas chromatography and mass spectrometry. J Chromatogr 110(1):91\u2013102","journal-title":"J Chromatogr"},{"issue":"1","key":"15_CR52","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.trecan.2016.12.003","volume":"3","author":"S Yoshihama","year":"2017","unstructured":"Yoshihama S, Vijayan S, Sidiq T, Kobayashi KS (2017) NLRC5\/CITA: a key player in cancer immune surveillance. Trends Cancer 3(1):28\u201338. https:\/\/doi.org\/10.1016\/j.trecan.2016.12.003","journal-title":"Trends Cancer"},{"issue":"8","key":"15_CR53","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00384-008-0488-y","volume":"23","author":"P Kiewe","year":"2008","unstructured":"Kiewe P, Mansmann V, Scheibenbogen C, Buhr HJ, Thiel E, Nagorsen D (2008) HLA-A2 expression, stage, and survival in colorectal cancer. Int J Colorectal Dis 23(8):767\u2013772. https:\/\/doi.org\/10.1007\/s00384-008-0488-y","journal-title":"Int J Colorectal Dis"},{"issue":"11","key":"15_CR54","doi-asserted-by":"publisher","first-page":"E1555","DOI":"10.1073\/pnas.1521812113","volume":"113","author":"SC Tripathi","year":"2016","unstructured":"Tripathi SC, Peters HL, Taguchi A, Katayama H, Wang H, Momin A, Jolly MK, Celiktas M, Rodriguez-Canales J, Liu H, Behrens C, Wistuba II, Ben-Jacob E, Levine H, Molldrem JJ, Hanash SM, Ostrin EJ (2016) Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome. Proc Natl Acad Sci U S A 113(11):E1555\u2013E1564. https:\/\/doi.org\/10.1073\/pnas.1521812113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"15_CR55","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00262-009-0769-5","volume":"59","author":"B Seliger","year":"2010","unstructured":"Seliger B, Stoehr R, Handke D, Mueller A, Ferrone S, Wullich B, Tannapfel A, Hofstaedter F, Hartmann A (2010) Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. Cancer Immunol Immunother 59(4):529\u2013540. https:\/\/doi.org\/10.1007\/s00262-009-0769-5","journal-title":"Cancer Immunol Immunother"},{"issue":"6","key":"15_CR56","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/gcc.20441","volume":"46","author":"AM Mehta","year":"2007","unstructured":"Mehta AM, Jordanova ES, van Wezel T, Uh HW, Corver WE, Kwappenberg KM, Verduijn W, Kenter GG, van der Burg SH, Fleuren GJ (2007) Genetic variation of antigen processing machinery components and association with cervical carcinoma. Genes Chromosomes Cancer 46(6):577\u2013586. https:\/\/doi.org\/10.1002\/gcc.20441","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"15_CR57","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/gcc.20648","volume":"48","author":"AM Mehta","year":"2009","unstructured":"Mehta AM, Jordanova ES, Corver WE, van Wezel T, Uh HW, Kenter GG, Jan Fleuren G (2009) Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. Genes Chromosomes Cancer 48(5):410\u2013418. https:\/\/doi.org\/10.1002\/gcc.20648","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"15_CR58","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1305531","volume":"6","author":"MH Pedersen","year":"2017","unstructured":"Pedersen MH, Hood BL, Beck HC, Conrads TP, Ditzel HJ, Leth-Larsen R (2017) Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors. Oncoimmunology 6(5):e1305531. https:\/\/doi.org\/10.1080\/2162402X.2017.1305531","journal-title":"Oncoimmunology"},{"issue":"8","key":"15_CR59","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.4049\/jimmunol.163.8.4224","volume":"163","author":"AK Johnsen","year":"1999","unstructured":"Johnsen AK, Templeton DJ, Sy M, Harding CV (1999) Deficiency of transporter for antigen presentation (TAP) in tumor cells allows evasion of immune surveillance and increases tumorigenesis. J Immunol 163(8):4224\u20134231","journal-title":"J Immunol"},{"issue":"1","key":"15_CR60","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/1097-0215(20010120)95:1<23::AID-IJC1004>3.0.CO;2-4","volume":"95","author":"J Kamarashev","year":"2001","unstructured":"Kamarashev J, Ferrone S, Seifert B, Boni R, Nestle FO, Burg G, Dummer R (2001) TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis. Int J Cancer 95(1):23\u201328","journal-title":"Int J Cancer"},{"issue":"4","key":"15_CR61","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3892\/or_00000717","volume":"23","author":"N Bandoh","year":"2010","unstructured":"Bandoh N, Ogino T, Katayama A, Takahara M, Katada A, Hayashi T, Harabuchi Y (2010) HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis. Oncol Rep 23(4):933\u2013939","journal-title":"Oncol Rep"},{"issue":"4","key":"15_CR62","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3892\/ijo.2011.1274","volume":"40","author":"K Tanaka","year":"2012","unstructured":"Tanaka K, Tsuchikawa T, Miyamoto M, Maki T, Ichinokawa M, Kubota KC, Shichinohe T, Hirano S, Ferrone S, Dosaka-Akita H, Matsuno Y, Kondo S (2012) Down-regulation of human leukocyte antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients. Int J Oncol 40(4):965\u2013974. https:\/\/doi.org\/10.3892\/ijo.2011.1274","journal-title":"Int J Oncol"},{"issue":"7","key":"15_CR63","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1158\/1078-0432.CCR-04-2146","volume":"11","author":"M Meissner","year":"2005","unstructured":"Meissner M, Reichert TE, Kunkel M, Gooding W, Whiteside TL, Ferrone S, Seliger B (2005) Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. Clin Cancer Res 11(7):2552\u20132560. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-2146","journal-title":"Clin Cancer Res"},{"issue":"3","key":"15_CR64","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0002-9440(10)65321-7","volume":"154","author":"T Kageshita","year":"1999","unstructured":"Kageshita T, Hirai S, Ono T, Hicklin DJ, Ferrone S (1999) Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. Am J Pathol 154(3):745\u2013754. https:\/\/doi.org\/10.1016\/S0002-9440(10)65321-7","journal-title":"Am J Pathol"},{"issue":"17","key":"15_CR65","doi-asserted-by":"publisher","first-page":"7926","DOI":"10.1158\/0008-5472.CAN-04-3977","volume":"65","author":"Y Lou","year":"2005","unstructured":"Lou Y, Vitalis TZ, Basha G, Cai B, Chen SS, Choi KB, Jeffries AP, Elliott WM, Atkins D, Seliger B, Jefferies WA (2005) Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival. Cancer Res 65(17):7926\u20137933. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-3977","journal-title":"Cancer Res"},{"issue":"10","key":"15_CR66","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.prp.2018.07.018","volume":"214","author":"J Meng","year":"2018","unstructured":"Meng J, Li W, Zhang M, Hao Z, Fan S, Zhang L, Liang C (2018) An update meta-analysis and systematic review of TAP polymorphisms as potential biomarkers for judging cancer risk. Pathol Res Pract 214(10):1556\u20131563. https:\/\/doi.org\/10.1016\/j.prp.2018.07.018","journal-title":"Pathol Res Pract"},{"issue":"7","key":"15_CR67","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3109\/1354750X.2013.827742","volume":"18","author":"H Chung","year":"2013","unstructured":"Chung H, Cho H, Perry C, Song J, Ylaya K, Lee H, Kim JH (2013) Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. Biomarkers 18(7):573\u2013579. https:\/\/doi.org\/10.3109\/1354750X.2013.827742","journal-title":"Biomarkers"},{"issue":"1","key":"15_CR68","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.surg.2006.05.009","volume":"141","author":"CM Leys","year":"2007","unstructured":"Leys CM, Nomura S, LaFleur BJ, Ferrone S, Kaminishi M, Montgomery E, Goldenring JR (2007) Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery 141(1):41\u201350. https:\/\/doi.org\/10.1016\/j.surg.2006.05.009","journal-title":"Surgery"},{"issue":"4","key":"15_CR69","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/ijc.20499","volume":"113","author":"JM Romero","year":"2005","unstructured":"Romero JM, Jimenez P, Cabrera T, Cozar JM, Pedrinaci S, Tallada M, Garrido F, Ruiz-Cabello F (2005) Coordinated downregulation of the antigen presentation machinery and HLA class I\/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer. Int J Cancer 113(4):605\u2013610. https:\/\/doi.org\/10.1002\/ijc.20499","journal-title":"Int J Cancer"},{"key":"15_CR70","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0647-1","volume":"13","author":"L Sokol","year":"2015","unstructured":"Sokol L, Koelzer VH, Rau TT, Karamitopoulou E, Zlobec I, Lugli A (2015) Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer. J Transl Med 13:279. https:\/\/doi.org\/10.1186\/s12967-015-0647-1","journal-title":"J Transl Med"},{"issue":"2","key":"15_CR71","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00403-003-0393-8","volume":"295","author":"J Dissemond","year":"2003","unstructured":"Dissemond J, Kothen T, Mors J, Weimann TK, Lindeke A, Goos M, Wagner SN (2003) Downregulation of tapasin expression in progressive human malignant melanoma. Arch Dermatol Res 295(2):43\u201349. https:\/\/doi.org\/10.1007\/s00403-003-0393-8","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"15_CR72","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1023\/B:JOCI.0000029118.51587.d9","volume":"24","author":"HR Turnquist","year":"2004","unstructured":"Turnquist HR, Kohlgraf KG, McIlhaney MM, Mosley RL, Hollingsworth MA, Solheim JC (2004) Tapasin decreases immune responsiveness to a model tumor antigen. J Clin Immunol 24(4):462\u2013470. https:\/\/doi.org\/10.1023\/B:JOCI.0000029118.51587.d9","journal-title":"J Clin Immunol"},{"issue":"3","key":"15_CR73","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.3892\/ol.2015.3471","volume":"10","author":"X Li","year":"2015","unstructured":"Li X, Guo F, Liu Y, Chen HJ, Wen F, Zou B, Li D, Qin Q, Liu X, Shen Y, Wang Y (2015) NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients. Oncol Lett 10(3):1533\u20131540. https:\/\/doi.org\/10.3892\/ol.2015.3471","journal-title":"Oncol Lett"},{"issue":"2","key":"15_CR74","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00262-011-1153-9","volume":"61","author":"B Seliger","year":"2012","unstructured":"Seliger B (2012) Novel insights into the molecular mechanisms of HLA class I abnormalities. Cancer Immunol Immunother 61(2):249\u2013254. https:\/\/doi.org\/10.1007\/s00262-011-1153-9","journal-title":"Cancer Immunol Immunother"},{"issue":"4","key":"15_CR75","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","volume":"168","author":"P Sharma","year":"2017","unstructured":"Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A (2017) Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell 168(4):707\u2013723. https:\/\/doi.org\/10.1016\/j.cell.2017.01.017","journal-title":"Cell"},{"issue":"6","key":"15_CR76","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.immuni.2016.06.001","volume":"44","author":"JM Pitt","year":"2016","unstructured":"Pitt JM, Vetizou M, Daillere R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, Zitvogel L (2016) Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity 44(6):1255\u20131269. https:\/\/doi.org\/10.1016\/j.immuni.2016.06.001","journal-title":"Immunity"},{"issue":"9","key":"15_CR77","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1158\/2159-8290.CD-15-0563","volume":"5","author":"A Ribas","year":"2015","unstructured":"Ribas A (2015) Adaptive immune resistance: how cancer protects from immune attack. Cancer Discov 5(9):915\u2013919. https:\/\/doi.org\/10.1158\/2159-8290.CD-15-0563","journal-title":"Cancer Discov"},{"issue":"6","key":"15_CR78","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1158\/1078-0432.CCR-17-2267","volume":"24","author":"TN Gide","year":"2018","unstructured":"Gide TN, Wilmott JS, Scolyer RA, Long GV (2018) Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma. Clin Cancer Res 24(6):1260\u20131270. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-2267","journal-title":"Clin Cancer Res"},{"issue":"10105","key":"15_CR79","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/S0140-6736(17)31601-X","volume":"390","author":"J Schachter","year":"2017","unstructured":"Schachter J, Ribas A, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank C, Petrella TM, Hamid O, Zhou H, Ebbinghaus S, Ibrahim N, Robert C (2017) Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet 390(10105):1853\u20131862. https:\/\/doi.org\/10.1016\/S0140-6736(17)31601-X","journal-title":"Lancet"},{"issue":"11","key":"15_CR80","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s00262-008-0532-3","volume":"57","author":"N Aptsiauri","year":"2008","unstructured":"Aptsiauri N, Carretero R, Garcia-Lora A, Real LM, Cabrera T, Garrido F (2008) Regressing and progressing metastatic lesions: resistance to immunotherapy is predetermined by irreversible HLA class I antigen alterations. Cancer Immunol Immunother 57(11):1727\u20131733. https:\/\/doi.org\/10.1007\/s00262-008-0532-3","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"15_CR81","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1172\/JCI114984","volume":"87","author":"CM D\u2019Urso","year":"1991","unstructured":"D\u2019Urso CM, Wang ZG, Cao Y, Tatake R, Zeff RA, Ferrone S (1991) Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression. J Clin Invest 87(1):284\u2013292. https:\/\/doi.org\/10.1172\/JCI114984","journal-title":"J Clin Invest"},{"issue":"2","key":"15_CR82","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/jnci\/88.2.100","volume":"88","author":"NP Restifo","year":"1996","unstructured":"Restifo NP, Marincola FM, Kawakami Y, Taubenberger J, Yannelli JR, Rosenberg SA (1996) Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J Natl Cancer Inst 88(2):100\u2013108","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"15_CR83","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.4049\/jimmunol.167.3.1809","volume":"167","author":"GA Ohnmacht","year":"2001","unstructured":"Ohnmacht GA, Wang E, Mocellin S, Abati A, Filie A, Fetsch P, Riker AI, Kammula US, Rosenberg SA, Marincola FM (2001) Short-term kinetics of tumor antigen expression in response to vaccination. J Immunol 167(3):1809\u20131820","journal-title":"J Immunol"},{"issue":"23","key":"15_CR84","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMoa1609279","volume":"375","author":"E Tran","year":"2016","unstructured":"Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA (2016) T-cell transfer therapy targeting mutant KRAS in cancer. N Engl J Med 375(23):2255\u20132262. https:\/\/doi.org\/10.1056\/NEJMoa1609279","journal-title":"N Engl J Med"},{"issue":"17","key":"15_CR85","doi-asserted-by":"publisher","first-page":"28312","DOI":"10.18632\/oncotarget.16048","volume":"8","author":"B Schrors","year":"2017","unstructured":"Schrors B, Lubcke S, Lennerz V, Fatho M, Bicker A, Wolfel C, Derigs P, Hankeln T, Schadendorf D, Paschen A, Wolfel T (2017) HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model. Oncotarget 8(17):28312\u201328327. https:\/\/doi.org\/10.18632\/oncotarget.16048","journal-title":"Oncotarget"},{"issue":"9","key":"15_CR86","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1056\/NEJMoa1604958","volume":"375","author":"JM Zaretsky","year":"2016","unstructured":"Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TN, Lo RS, Ribas A (2016) Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 375(9):819\u2013829. https:\/\/doi.org\/10.1056\/NEJMoa1604958","journal-title":"N Engl J Med"},{"issue":"12","key":"15_CR87","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1158\/2159-8290.CD-17-0593","volume":"7","author":"S Gettinger","year":"2017","unstructured":"Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K (2017) Impaired HLA class i antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer. Cancer Discov 7(12):1420\u20131435. https:\/\/doi.org\/10.1158\/2159-8290.CD-17-0593","journal-title":"Cancer Discov"},{"issue":"16","key":"15_CR88","doi-asserted-by":"publisher","first-page":"eaaq0015","DOI":"10.1126\/sciimmunol.aaq0015","volume":"2","author":"Faisal Alsufyani","year":"2017","unstructured":"Alsufyani F, Pillai S (2017) JAKing up resistance to immunotherapy. Sci Immunol 2(16). https:\/\/doi.org\/10.1126\/sciimmunol.aaq0015","journal-title":"Science Immunology"},{"issue":"1","key":"15_CR89","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.1038\/s41467-018-06300-3","volume":"9","author":"KG Paulson","year":"2018","unstructured":"Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG (2018) Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nat Commun 9(1):3868. https:\/\/doi.org\/10.1038\/s41467-018-06300-3","journal-title":"Nat Commun"},{"issue":"17","key":"15_CR90","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1158\/0008-5472.CAN-16-3172","volume":"77","author":"M Donia","year":"2017","unstructured":"Donia M, Harbst K, van Buuren M, Kvistborg P, Lindberg MF, Andersen R, Idorn M, Munir Ahmad S, Ellebaek E, Mueller A, Fagone P, Nicoletti F, Libra M, Lauss M, Hadrup SR, Schmidt H, Andersen MH, Thor Straten P, Nilsson JA, Schumacher TN, Seliger B, Jonsson G, Svane IM (2017) Acquired immune resistance follows complete tumor regression without loss of target antigens or ifngamma signaling. Cancer Res 77(17):4562\u20134566. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-3172","journal-title":"Cancer Res"},{"key":"15_CR91","doi-asserted-by":"publisher","unstructured":"Johnson DB, Nixon MJ, Wang Y, Wang DY, Castellanos E, Estrada MV, Ericsson-Gonzalez PI, Cote CH, Salgado R, Sanchez V, Dean PT, Opalenik SR, Schreeder DM, Rimm DL, Kim JY, Bordeaux J, Loi S, Horn L, Sanders ME, Ferrell PB Jr, Xu Y, Sosman JA, Davis RS, Balko JM (2018) Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3\/FCRL6 engagement. JCI Insight 3(24). https:\/\/doi.org\/10.1172\/jci.insight.120360","DOI":"10.1172\/jci.insight.120360"},{"issue":"7","key":"15_CR92","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1002\/1878-0261.12093","volume":"11","author":"S Terry","year":"2017","unstructured":"Terry S, Savagner P, Ortiz-Cuaran S, Mahjoubi L, Saintigny P, Thiery JP, Chouaib S (2017) New insights into the role of EMT in tumor immune escape. Mol Oncol 11(7):824\u2013846. https:\/\/doi.org\/10.1002\/1878-0261.12093","journal-title":"Mol Oncol"},{"issue":"1","key":"15_CR93","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41598-017-01000-2","volume":"7","author":"BD Shields","year":"2017","unstructured":"Shields BD, Mahmoud F, Taylor EM, Byrum SD, Sengupta D, Koss B, Baldini G, Ransom S, Cline K, Mackintosh SG, Edmondson RD, Shalin S, Tackett AJ (2017) Indicators of responsiveness to immune checkpoint inhibitors. Sci Rep 7(1):807. https:\/\/doi.org\/10.1038\/s41598-017-01000-2","journal-title":"Sci Rep"},{"issue":"22","key":"15_CR94","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1007\/s00018-018-2908-7","volume":"75","author":"N Arenas-Ramirez","year":"2018","unstructured":"Arenas-Ramirez N, Sahin D, Boyman O (2018) Epigenetic mechanisms of tumor resistance to immunotherapy. Cell Mol Life Sci 75(22):4163\u20134176. https:\/\/doi.org\/10.1007\/s00018-018-2908-7","journal-title":"Cell Mol Life Sci"},{"issue":"16","key":"15_CR95","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1158\/1078-0432.CCR-13-2627","volume":"20","author":"EK Moon","year":"2014","unstructured":"Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Pure E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM (2014) Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clin Cancer Res 20(16):4262\u20134273. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-2627","journal-title":"Clin Cancer Res"},{"issue":"25","key":"15_CR96","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.1182\/blood-2015-01-621474","volume":"125","author":"S Ninomiya","year":"2015","unstructured":"Ninomiya S, Narala N, Huye L, Yagyu S, Savoldo B, Dotti G, Heslop HE, Brenner MK, Rooney CM, Ramos CA (2015) Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs. Blood 125(25):3905\u20133916. https:\/\/doi.org\/10.1182\/blood-2015-01-621474","journal-title":"Blood"},{"issue":"43","key":"15_CR97","doi-asserted-by":"publisher","first-page":"75675","DOI":"10.18632\/oncotarget.18523","volume":"8","author":"HR Keller","year":"2017","unstructured":"Keller HR, Zhang X, Li L, Schaider H, Wells JW (2017) Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma. Oncotarget 8(43):75675\u201375686. https:\/\/doi.org\/10.18632\/oncotarget.18523","journal-title":"Oncotarget"},{"issue":"5","key":"15_CR98","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1158\/1078-0432.CCR-07-1066","volume":"14","author":"Y Lou","year":"2008","unstructured":"Lou Y, Basha G, Seipp RP, Cai B, Chen SS, Moise AR, Jeffries AP, Gopaul RS, Vitalis TZ, Jefferies WA (2008) Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival. Clin Cancer Res 14(5):1494\u20131501. https:\/\/doi.org\/10.1158\/1078-0432.CCR-07-1066","journal-title":"Clin Cancer Res"},{"issue":"3","key":"15_CR99","first-page":"1095","volume":"61","author":"B Seliger","year":"2001","unstructured":"Seliger B, Wollscheid U, Momburg F, Blankenstein T, Huber C (2001) Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells. Cancer Res 61(3):1095\u20131099","journal-title":"Cancer Res"},{"issue":"6","key":"15_CR100","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1151593","volume":"5","author":"GM Rodriguez","year":"2016","unstructured":"Rodriguez GM, Bobbala D, Serrano D, Mayhue M, Champagne A, Saucier C, Steimle V, Kufer TA, Menendez A, Ramanathan S, Ilangumaran S (2016) NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes. Oncoimmunology 5(6):e1151593. https:\/\/doi.org\/10.1080\/2162402X.2016.1151593","journal-title":"Oncoimmunology"},{"issue":"40","key":"15_CR101","doi-asserted-by":"publisher","first-page":"30419","DOI":"10.1074\/jbc.M109.094284","volume":"285","author":"J Bukur","year":"2010","unstructured":"Bukur J, Herrmann F, Handke D, Recktenwald C, Seliger B (2010) Identification of E2F1 as an important transcription factor for the regulation of tapasin expression. J Biol Chem 285(40):30419\u201330426. https:\/\/doi.org\/10.1074\/jbc.M109.094284","journal-title":"J Biol Chem"},{"issue":"49","key":"15_CR102","doi-asserted-by":"publisher","first-page":"19890","DOI":"10.1073\/pnas.1309781110","volume":"110","author":"E Zervoudi","year":"2013","unstructured":"Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E (2013) Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc Natl Acad Sci U S A 110(49):19890\u201319895. https:\/\/doi.org\/10.1073\/pnas.1309781110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"15_CR103","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40425-018-0376-0","volume":"6","author":"MU Mushtaq","year":"2018","unstructured":"Mushtaq MU, Papadas A, Pagenkopf A, Flietner E, Morrow Z, Chaudhary SG, Asimakopoulos F (2018) Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers. J Immunother Cancer 6(1):65. https:\/\/doi.org\/10.1186\/s40425-018-0376-0","journal-title":"J Immunother Cancer"},{"issue":"4","key":"15_CR104","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1373233","volume":"7","author":"K Subbarayan","year":"2018","unstructured":"Subbarayan K, Leisz S, Wickenhauser C, Bethmann D, Massa C, Steven A, Seliger B (2018) Biglycan-mediated upregulation of MHC class I expression in HER-2\/neu-transformed cells. Oncoimmunology 7(4):e1373233. https:\/\/doi.org\/10.1080\/2162402X.2017.1373233","journal-title":"Oncoimmunology"},{"issue":"3","key":"15_CR105","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/pmic.200600506","volume":"7","author":"CV Recktenwald","year":"2007","unstructured":"Recktenwald CV, Mendler S, Lichtenfels R, Kellner R, Seliger B (2007) Influence of Ki-ras-driven oncogenic transformation on the protein network of murine fibroblasts. Proteomics 7(3):385\u2013398. https:\/\/doi.org\/10.1002\/pmic.200600506","journal-title":"Proteomics"},{"issue":"6","key":"15_CR106","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1046\/j.1365-3083.1997.d01-176.x","volume":"46","author":"B Seliger","year":"1997","unstructured":"Seliger B, Dunn T, Schwenzer A, Casper J, Huber C, Schmoll HJ (1997) Analysis of the MHC class I antigen presentation machinery in human embryonal carcinomas: evidence for deficiencies in TAP, LMP and MHC class I expression and their upregulation by IFN-gamma. Scand J Immunol 46(6):625\u2013632","journal-title":"Scand J Immunol"},{"issue":"1","key":"15_CR107","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0952-7915(99)80014-4","volume":"11","author":"K Fruh","year":"1999","unstructured":"Fruh K, Yang Y (1999) Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol 11(1):76\u201381","journal-title":"Curr Opin Immunol"},{"issue":"3","key":"15_CR108","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1089\/jir.1997.17.121","volume":"17","author":"T Decker","year":"1997","unstructured":"Decker T, Kovarik P, Meinke A (1997) GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J Interferon Cytokine Res 17(3):121\u2013134. https:\/\/doi.org\/10.1089\/jir.1997.17.121","journal-title":"J Interferon Cytokine Res"},{"key":"15_CR109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01135","volume":"9","author":"A Michalska","year":"2018","unstructured":"Michalska A, Blaszczyk K, Wesoly J, Bluyssen HAR (2018) A positive feedback amplifier circuit that regulates interferon (IFN)-stimulated gene expression and controls type I and type II IFN responses. Front Immunol 9:1135. https:\/\/doi.org\/10.3389\/fimmu.2018.01135","journal-title":"Front Immunol"},{"issue":"11","key":"15_CR110","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/S0198-8859(00)00198-1","volume":"61","author":"SJ Gobin","year":"2000","unstructured":"Gobin SJ, van den Elsen PJ (2000) Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G. Hum Immunol 61(11):1102\u20131107","journal-title":"Hum Immunol"},{"issue":"1","key":"15_CR111","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1038\/s41598-017-02608-0","volume":"7","author":"C Ritter","year":"2017","unstructured":"Ritter C, Fan K, Paschen A, Reker Hardrup S, Ferrone S, Nghiem P, Ugurel S, Schrama D, Becker JC (2017) Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma. Sci Rep 7(1):2290. https:\/\/doi.org\/10.1038\/s41598-017-02608-0","journal-title":"Sci Rep"},{"issue":"3","key":"15_CR112","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00262-017-2091-y","volume":"67","author":"D Briere","year":"2018","unstructured":"Briere D, Sudhakar N, Woods DM, Hallin J, Engstrom LD, Aranda R, Chiang H, Sodre AL, Olson P, Weber JS, Christensen JG (2018) The class I\/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy. Cancer Immunol Immunother 67(3):381\u2013392. https:\/\/doi.org\/10.1007\/s00262-017-2091-y","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"15_CR113","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1521-6616(03)00200-6","volume":"109","author":"PJ Elsen van den","year":"2003","unstructured":"van den Elsen PJ, Holling TM, van der Stoep N, Boss JM (2003) DNA methylation and expression of major histocompatibility complex class I and class II transactivator genes in human developmental tumor cells and in T cell malignancies. Clin Immunol 109(1):46\u201352","journal-title":"Clin Immunol"},{"issue":"16","key":"15_CR114","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.18632\/oncotarget.2222","volume":"5","author":"V Vlkova","year":"2014","unstructured":"Vlkova V, Stepanek I, Hruskova V, Senigl F, Mayerova V, Sramek M, Simova J, Bieblova J, Indrova M, Hejhal T, Derian N, Klatzmann D, Six A, Reinis M (2014) Epigenetic regulations in the IFNgamma signalling pathway: IFNgamma-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes. Oncotarget 5(16):6923\u20136935. https:\/\/doi.org\/10.18632\/oncotarget.2222","journal-title":"Oncotarget"},{"issue":"1","key":"15_CR115","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41467-017-02630-w","volume":"9","author":"N Luo","year":"2018","unstructured":"Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, Sanders ME, Manning HC, Balko JM (2018) DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer. Nat Commun 9(1):248. https:\/\/doi.org\/10.1038\/s41467-017-02630-w","journal-title":"Nat Commun"},{"issue":"3","key":"15_CR116","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/d41573-019-00025-8","volume":"18","author":"Katie Kingwell","year":"2019","unstructured":"Kingwell K (2019) Uncoupling resistance to cancer immunotherapy. Nat Rev Drug Discov. https:\/\/doi.org\/10.1038\/d41573-019-00025-8","journal-title":"Nature Reviews Drug Discovery"},{"key":"15_CR117","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cytogfr.2017.07.001","volume":"36","author":"B Seliger","year":"2017","unstructured":"Seliger B (2017) Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors. Cytokine Growth Factor Rev 36:49\u201356. https:\/\/doi.org\/10.1016\/j.cytogfr.2017.07.001","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6257","key":"15_CR118","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.aad0095","volume":"350","author":"EM Allen Van","year":"2015","unstructured":"Van Allen EM, Miao D, Schilling B, Shukla SA, Blank C, Zimmer L, Sucker A, Hillen U, Foppen MHG, Goldinger SM, Utikal J, Hassel JC, Weide B, Kaehler KC, Loquai C, Mohr P, Gutzmer R, Dummer R, Gabriel S, Wu CJ, Schadendorf D, Garraway LA (2015) Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350(6257):207\u2013211. https:\/\/doi.org\/10.1126\/science.aad0095","journal-title":"Science"},{"issue":"7","key":"15_CR119","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.celrep.2015.04.031","volume":"11","author":"L Corrales","year":"2015","unstructured":"Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, Woo SR, Lemmens E, Banda T, Leong JJ, Metchette K, Dubensky TW Jr, Gajewski TF (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep 11(7):1018\u20131030. https:\/\/doi.org\/10.1016\/j.celrep.2015.04.031","journal-title":"Cell Rep"},{"issue":"7","key":"15_CR120","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1084\/jem.20130066","volume":"210","author":"RB Holmgaard","year":"2013","unstructured":"Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP (2013) Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med 210(7):1389\u20131402. https:\/\/doi.org\/10.1084\/jem.20130066","journal-title":"J Exp Med"},{"issue":"1","key":"15_CR121","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.canlet.2015.10.009","volume":"370","author":"H Tang","year":"2016","unstructured":"Tang H, Qiao J, Fu YX (2016) Immunotherapy and tumor microenvironment. Cancer Lett 370(1):85\u201390. https:\/\/doi.org\/10.1016\/j.canlet.2015.10.009","journal-title":"Cancer Lett"},{"issue":"7528","key":"15_CR122","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nature13988","volume":"515","author":"MM Gubin","year":"2014","unstructured":"Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD (2014) Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515(7528):577\u2013581. https:\/\/doi.org\/10.1038\/nature13988","journal-title":"Nature"},{"issue":"Suppl 1","key":"15_CR123","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1111\/j.1743-7563.2010.01271.x","volume":"6","author":"FS Hodi","year":"2010","unstructured":"Hodi FS (2010) Overcoming immunological tolerance to melanoma: targeting CTLA-4. Asia Pac J Clin Oncol 6(Suppl 1):S16\u2013S23. https:\/\/doi.org\/10.1111\/j.1743-7563.2010.01271.x","journal-title":"Asia Pac J Clin Oncol"},{"issue":"11","key":"15_CR124","doi-asserted-by":"publisher","first-page":"7244","DOI":"10.4049\/jimmunol.179.11.7244","volume":"179","author":"WL Redmond","year":"2007","unstructured":"Redmond WL, Gough MJ, Charbonneau B, Ratliff TL, Weinberg AD (2007) Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol 179(11):7244\u20137253","journal-title":"J Immunol"},{"issue":"6230","key":"15_CR125","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1126\/science.aaa4967","volume":"348","author":"SA Rosenberg","year":"2015","unstructured":"Rosenberg SA, Restifo NP (2015) Adoptive cell transfer as personalized immunotherapy for human cancer. Science 348(6230):62\u201368. https:\/\/doi.org\/10.1126\/science.aaa4967","journal-title":"Science"},{"key":"15_CR126","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pharmthera.2016.06.010","volume":"166","author":"GL Beatty","year":"2016","unstructured":"Beatty GL, O'Hara M (2016) Chimeric antigen receptor-modified T cells for the treatment of solid tumors: defining the challenges and next steps. Pharmacol Ther 166:30\u201339. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.06.010","journal-title":"Pharmacol Ther"},{"issue":"11","key":"15_CR127","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1089\/hum.2017.115","volume":"28","author":"H Abken","year":"2017","unstructured":"Abken H (2017) Driving CARs on the highway to solid cancer: some considerations on the adoptive therapy with CAR T Cells. Hum Gene Ther 28(11):1047\u20131060. https:\/\/doi.org\/10.1089\/hum.2017.115","journal-title":"Hum Gene Ther"},{"issue":"1","key":"15_CR128","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1056\/NEJMoa1504030","volume":"373","author":"J Larkin","year":"2015","unstructured":"Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, Carlino MS, Haanen JB, Maio M, Marquez-Rodas I, McArthur GA, Ascierto PA, Long GV, Callahan MK, Postow MA, Grossmann K, Sznol M, Dreno B, Bastholt L, Yang A, Rollin LM, Horak C, Hodi FS, Wolchok JD (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373(1):23\u201334. https:\/\/doi.org\/10.1056\/NEJMoa1504030","journal-title":"N Engl J Med"},{"key":"15_CR129","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3389\/fonc.2014.00385","volume":"4","author":"MK Callahan","year":"2014","unstructured":"Callahan MK, Postow MA, Wolchok JD (2014) CTLA-4 and PD-1 pathway blockade: combinations in the clinic. Front Oncol 4:385. https:\/\/doi.org\/10.3389\/fonc.2014.00385","journal-title":"Front Oncol"},{"issue":"2","key":"15_CR130","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1158\/0008-5472.CAN-12-2179","volume":"73","author":"MM Berrien-Elliott","year":"2013","unstructured":"Berrien-Elliott MM, Jackson SR, Meyer JM, Rouskey CJ, Nguyen TL, Yagita H, Greenberg PD, DiPaolo RJ, Teague RM (2013) Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance. Cancer Res 73(2):605\u2013616. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-2179","journal-title":"Cancer Res"},{"issue":"2","key":"15_CR131","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1158\/2326-6066.CIR-13-0031-T","volume":"2","author":"WL Redmond","year":"2014","unstructured":"Redmond WL, Linch SN, Kasiewicz MJ (2014) Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity. Cancer Immunol Res 2(2):142\u2013153. https:\/\/doi.org\/10.1158\/2326-6066.CIR-13-0031-T","journal-title":"Cancer Immunol Res"},{"key":"15_CR132","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2051-1426-2-3","volume":"2","author":"S Spranger","year":"2014","unstructured":"Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF (2014) Mechanism of tumor rejection with doublets of CTLA-4, PD-1\/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J Immunother Cancer 2:3. https:\/\/doi.org\/10.1186\/2051-1426-2-3","journal-title":"J Immunother Cancer"},{"issue":"1","key":"15_CR133","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s40425-017-0300-z","volume":"5","author":"I Puzanov","year":"2017","unstructured":"Puzanov I, Diab A, Abdallah K, Bingham CO 3rd, Brogdon C, Dadu R, Hamad L, Kim S, Lacouture ME, LeBoeuf NR, Lenihan D, Onofrei C, Shannon V, Sharma R, Silk AW, Skondra D, Suarez-Almazor ME, Wang Y, Wiley K, Kaufman HL, Ernstoff MS, Society for Immunotherapy of Cancer Toxicity Management Working Group (2017) Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. J Immunother Cancer 5(1):95. https:\/\/doi.org\/10.1186\/s40425-017-0300-z","journal-title":"J Immunother Cancer"},{"issue":"6","key":"15_CR134","doi-asserted-by":"publisher","first-page":"997","DOI":"10.4161\/onci.19865","volume":"1","author":"JS Wilmott","year":"2012","unstructured":"Wilmott JS, Scolyer RA, Long GV, Hersey P (2012) Combined targeted therapy and immunotherapy in the treatment of advanced melanoma. Oncoimmunology 1(6):997\u2013999. https:\/\/doi.org\/10.4161\/onci.19865","journal-title":"Oncoimmunology"},{"key":"15_CR135","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.2147\/OTT.S65802","volume":"9","author":"B Comin-Anduix","year":"2016","unstructured":"Comin-Anduix B, Escuin-Ordinas H, Ibarrondo FJ (2016) Tremelimumab: research and clinical development. Onco Targets Ther 9:1767\u20131776. https:\/\/doi.org\/10.2147\/OTT.S65802","journal-title":"Onco Targets Ther"},{"issue":"1","key":"15_CR136","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.cmet.2017.06.016","volume":"26","author":"RJ Kishton","year":"2017","unstructured":"Kishton RJ, Sukumar M, Restifo NP (2017) Metabolic regulation of T cell longevity and function in tumor immunotherapy. Cell Metab 26(1):94\u2013109. https:\/\/doi.org\/10.1016\/j.cmet.2017.06.016","journal-title":"Cell Metab"},{"issue":"4","key":"15_CR137","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/ni.3415","volume":"17","author":"CH Chang","year":"2016","unstructured":"Chang CH, Pearce EL (2016) Emerging concepts of T cell metabolism as a target of immunotherapy. Nat Immunol 17(4):364\u2013368. https:\/\/doi.org\/10.1038\/ni.3415","journal-title":"Nat Immunol"},{"issue":"6264","key":"15_CR138","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1126\/science.aac4255","volume":"350","author":"A Sivan","year":"2015","unstructured":"Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350(6264):1084\u20131089. https:\/\/doi.org\/10.1126\/science.aac4255","journal-title":"Science"},{"issue":"6264","key":"15_CR139","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1126\/science.aad1329","volume":"350","author":"M Vetizou","year":"2015","unstructured":"Vetizou M, Pitt JM, Daillere R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Berard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L (2015) Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350(6264):1079\u20131084. https:\/\/doi.org\/10.1126\/science.aad1329","journal-title":"Science"},{"issue":"6","key":"15_CR140","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.immuni.2015.11.014","volume":"43","author":"JR Conejo-Garcia","year":"2015","unstructured":"Conejo-Garcia JR, Rutkowski MR (2015) Small but mighty: selected commensal bacterial species determine the effectiveness of anti-cancer immunotherapies. Immunity 43(6):1037\u20131039. https:\/\/doi.org\/10.1016\/j.immuni.2015.11.014","journal-title":"Immunity"},{"issue":"2","key":"15_CR141","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1158\/2159-8290.CD-17-0833","volume":"8","author":"RW Jenkins","year":"2018","unstructured":"Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Canadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA (2018) Ex vivo profiling of PD-1 blockade using organotypic tumor spheroids. Cancer Discov 8(2):196\u2013215. https:\/\/doi.org\/10.1158\/2159-8290.CD-17-0833","journal-title":"Cancer Discov"},{"issue":"4","key":"15_CR142","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.celrep.2017.07.007","volume":"20","author":"D Zingg","year":"2017","unstructured":"Zingg D, Arenas-Ramirez N, Sahin D, Rosalia RA, Antunes AT, Haeusel J, Sommer L, Boyman O (2017) The Histone methyltransferase Ezh2 controls mechanisms of adaptive resistance to tumor immunotherapy. Cell Rep 20(4):854\u2013867. https:\/\/doi.org\/10.1016\/j.celrep.2017.07.007","journal-title":"Cell Rep"},{"issue":"16","key":"15_CR143","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1158\/1078-0432.CCR-15-2584","volume":"22","author":"H Zheng","year":"2016","unstructured":"Zheng H, Zhao W, Yan C, Watson CC, Massengill M, Xie M, Massengill C, Noyes DR, Martinez GV, Afzal R, Chen Z, Ren X, Antonia SJ, Haura EB, Ruffell B, Beg AA (2016) HDAC inhibitors enhance T-cell chemokine expression and augment response to PD-1 immunotherapy in lung adenocarcinoma. Clin Cancer Res 22(16):4119\u20134132. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-2584","journal-title":"Clin Cancer Res"},{"issue":"69","key":"15_CR144","doi-asserted-by":"publisher","first-page":"114156","DOI":"10.18632\/oncotarget.23169","volume":"8","author":"M Terranova-Barberio","year":"2017","unstructured":"Terranova-Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, Rosenblum MD, Budillon A, Munster PN (2017) HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget 8(69):114156\u2013114172. https:\/\/doi.org\/10.18632\/oncotarget.23169","journal-title":"Oncotarget"},{"issue":"12","key":"15_CR145","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1158\/2326-6066.CIR-15-0077-T","volume":"3","author":"DM Woods","year":"2015","unstructured":"Woods DM, Sodre AL, Villagra A, Sarnaik A, Sotomayor EM, Weber J (2015) HDAC inhibition upregulates PD-1 ligands in melanoma and augments immunotherapy with PD-1 blockade. Cancer Immunol Res 3(12):1375\u20131385. https:\/\/doi.org\/10.1158\/2326-6066.CIR-15-0077-T","journal-title":"Cancer Immunol Res"}],"container-title":["Methods in Molecular Biology","Biomarkers for Immunotherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-9773-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T01:09:42Z","timestamp":1695172182000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-9773-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"ISBN":["9781493997725","9781493997732"],"references-count":145,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-9773-2_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]},"assertion":[{"value":"10 September 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}