{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T03:14:28Z","timestamp":1794453268912,"version":"4.9.1"},"publisher-location":"Totowa, NJ","reference-count":26,"publisher":"Humana Press","isbn-type":[{"value":"9781603273688","type":"print"},{"value":"9781603273695","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-60327-369-5_12","type":"book-chapter","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T14:47:42Z","timestamp":1375454862000},"page":"253-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Generation of General and Tissue-Specific Gene Knockout Mouse Models"],"prefix":"10.1007","author":[{"given":"Xian-Cheng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"12_CR00121","doi-asserted-by":"crossref","first-page":"11463","DOI":"10.1016\/S0021-9258(18)33782-7","volume":"257","author":"P Siuta-Mangano","year":"1982","unstructured":"Siuta-Mangano P, Janero DR, Lane MD (1982) Association and assembly of triglyceride and phospholipid with glycosylated and unglycosylated apoproteins of very low density lipoprotein in the intact liver cell. J Biol Chem 257:11463\u201311467","journal-title":"J Biol Chem"},{"key":"12_CR00122","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1083\/jcb.99.6.1917","volume":"99","author":"D Banarjee","year":"1984","unstructured":"Banarjee D, Redman CM (1984) Biosynthesis of high density lipoprotein by chicken liver: conjugation of nascent lipids with apoprotein A1. J Cell Biol 99:1917\u20131926","journal-title":"J Cell Biol"},{"key":"12_CR00123","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0021-9150(95)05566-F","volume":"117","author":"H Gylling","year":"1995","unstructured":"Gylling H, Miettinen TA (1995) The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. Atherosclerosis 117:305\u2013308","journal-title":"Atherosclerosis"},{"key":"12_CR00124","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/362801a0","volume":"362","author":"R Ross","year":"1993","unstructured":"Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801\u2013808","journal-title":"Nature"},{"key":"12_CR00125","doi-asserted-by":"publisher","first-page":"8810","DOI":"10.1073\/pnas.87.22.8810","volume":"87","author":"M Freeman","year":"1990","unstructured":"Freeman M, Ashkenas J, Rees KJG, Kingsley DM, Copeland N, Jenkins NA, Krieger M (1990) An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci USA 87:8810\u20138814","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR00126","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/343531a0","volume":"343","author":"T Kodama","year":"1990","unstructured":"Kodama T, Freeman M, Rohrer LJ, Zabrewky J, Matsudaira P, Krieger M (1990) Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 343:531\u2013535","journal-title":"Nature"},{"key":"12_CR00127","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.cmet.2006.06.007","volume":"4","author":"SO Rahaman","year":"2006","unstructured":"Rahaman SO, Lennon DJ, Febbraio M, Podrez EA, Hazen SL, Silverstein RL (2006) A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4:211\u2013221","journal-title":"Cell Metab"},{"key":"12_CR00128","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.bbalip.2006.04.012","volume":"1761","author":"C Cavelier","year":"2006","unstructured":"Cavelier C, Lorenzi I, Rohrer L, von Eckardstein A (2006) Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim Biophys Acta 1761:655\u2013666","journal-title":"Biochim Biophys Acta"},{"key":"12_CR00129","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/01.mol.0000226116.35555.eb","volume":"17","author":"W Jessup","year":"2006","unstructured":"Jessup W, Gelissen IC, Gaus K, Kritharides L (2006) Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages. Curr Opin Lipidol 17:247\u2013257","journal-title":"Curr Opin Lipidol"},{"key":"12_CR001210","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0005-2760(90)90211-F","volume":"1044","author":"AH Merrill","year":"1990","unstructured":"Merrill AH, Jones DD (1990) An update of the enzymology and regulation sphingo\u00admyelin metabolism. Biochim Biophys Acta 1044:1\u201312","journal-title":"Biochim Biophys Acta"},{"key":"12_CR001211","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1432-1033.1997.00239.x","volume":"249","author":"B Weiss","year":"1997","unstructured":"Weiss B, Stoffel W (1997) Human and murine serine-palmitoyl-CoA transferase\u2014cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem 249:239\u2013247","journal-title":"Eur J Biochem"},{"key":"12_CR001212","doi-asserted-by":"publisher","first-page":"32108","DOI":"10.1074\/jbc.272.51.32108","volume":"272","author":"K Hanada","year":"1997","unstructured":"Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC, Nagiec MM (1997) A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J Biol Chem 272:32108\u201332114","journal-title":"J Biol Chem"},{"key":"12_CR001213","doi-asserted-by":"publisher","first-page":"10284","DOI":"10.1074\/jbc.M412348200","volume":"280","author":"MR Hojjati","year":"2005","unstructured":"Hojjati MR, Li Z, Zhou H, Tang S, Huan C, Ooi E, Lu S, Jiang XC (2005) Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. J Biol Chem 280:10284\u201310289","journal-title":"J Biol Chem"},{"key":"12_CR001214","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1161\/01.CIR.0000148370.60535.22","volume":"110","author":"TS Park","year":"2004","unstructured":"Park TS, Panek RL, Mueller SB, Hanselman JC, Rosebury WS, Robertson AW, Kindt EK, Homan R, Karathanasis SK, Rekhter MD (2004) Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. Circulation 110:3465\u20133471","journal-title":"Circulation"},{"key":"12_CR001215","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.bbalip.2005.08.006","volume":"1737","author":"MR Hojjati","year":"2005","unstructured":"Hojjati MR, Li Z, Jiang XC (2005) Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim Biophys Acta 1737:44\u201351","journal-title":"Biochim Biophys Acta"},{"key":"12_CR001216","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T","volume":"28","author":"FW Farley","year":"2000","unstructured":"Farley FW, Soriano P, Steffen LS, Dymecki SM (2000) Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28:106\u2013110","journal-title":"Genesis"},{"key":"12_CR001217","first-page":"245","volume":"103","author":"JR Jones","year":"2005","unstructured":"Jones JR, Shelton KD, Magnuson MA (2005) Strategies for the use of site-specific recombinases in genome engineering. Methods Mol Med 103:245\u2013257","journal-title":"Methods Mol Med"},{"key":"12_CR001218","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1073\/pnas.90.7.2812","volume":"90","author":"J Herz","year":"1993","unstructured":"Herz J, Gerard RD (1993) Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 90:2812\u20132816","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR001219","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.7660125","volume":"269","author":"R K\u00fchn","year":"1995","unstructured":"K\u00fchn R, Schwenk F, Aguet M, Rajewsky K (1995) Inducible gene targeting in mice. Science 269:1427\u20131429","journal-title":"Science"},{"key":"12_CR001220","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/0092-8674(93)90644-6","volume":"73","author":"H Gu","year":"1993","unstructured":"Gu H, Zou YR, Rajewsky R (1993) Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73:1155\u20131164","journal-title":"Cell"},{"key":"12_CR001221","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0076-6879(93)25054-6","volume":"225","author":"R Ramirez-Solis","year":"1993","unstructured":"Ramirez-Solis R, Davis AC, Bradley A (1993) Gene targeting in embryonic stem cells. Methods Enzymol 225:855\u2013878","journal-title":"Methods Enzymol"},{"key":"12_CR001222","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1158\/0008-5472.CAN-05-2699","volume":"66","author":"MH Kucherlapati","year":"2006","unstructured":"Kucherlapati MH, Nguyen AA, Bronson RT, Kucherlapati RS (2006) Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Res 66:3576\u20133583","journal-title":"Cancer Res"},{"key":"12_CR001223","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1136\/gut.2005.081745","volume":"55","author":"M Adachi","year":"2006","unstructured":"Adachi M, Kurotani R, Morimura K, Shah Y, Sanford M, Madison BB, Gumucio DL, Marin HE, Peters JM, Young HA, Gonzalez FJ (2006) PPAR{gamma} in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut 55:1104\u20131113","journal-title":"Gut"},{"key":"12_CR001224","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1096\/fj.05-4530fje","volume":"20","author":"LS Boesten","year":"2006","unstructured":"Boesten LS, Zadelaar AS, van Nieuwkoop A, Hu L, Jonkers J, van de Water B, Gijbels MJ, van der Made I, de Winther MP, Havekes LM, van Vlijmen BJ (2006) Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20:953\u2013955","journal-title":"FASEB J"},{"key":"12_CR001225","first-page":"93","volume":"22","author":"SI Grivennikov","year":"2005","unstructured":"Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya LN, Forster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA (2005) Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects. Immunity 22:93\u2013104","journal-title":"Immunity"},{"key":"12_CR001226","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1161\/01.ATV.0000249721.96666.e5","volume":"27","author":"R Liu","year":"2007","unstructured":"Liu R, Hojjati MR, Devlin CM, Hansen IH, Jiang XC (2007) Macrophage phospholipid transfer protein deficiency and ApoE secretion: impact on mouse plasma cholesterol levels and atherosclerosis. Arterioscler Thromb Vasc Biol 27:190\u2013196","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Methods in Molecular Biology","Lipoproteins and Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60327-369-5_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T23:04:15Z","timestamp":1675206255000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-60327-369-5_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781603273688","9781603273695"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/978-1-60327-369-5_12","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-60327-369-5","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"6 May 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}