{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:08:06Z","timestamp":1725530886041},"publisher-location":"Totowa, NJ","reference-count":44,"publisher":"Humana Press","isbn-type":[{"type":"print","value":"9781603279307"},{"type":"electronic","value":"9781603279314"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-1-60327-931-4_3","type":"book-chapter","created":{"date-parts":[[2009,4,18]],"date-time":"2009-04-18T23:23:44Z","timestamp":1240097024000},"page":"33-47","source":"Crossref","is-referenced-by-count":2,"title":["Human Trials for Neurodegenerative Disease"],"prefix":"10.1007","author":[{"given":"Claire M.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.J.","family":"Handley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,3,23]]},"reference":[{"key":"3_CR1_3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0896-6273(00)00083-0","volume":"28","author":"H Kawasaki","year":"2000","unstructured":"Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Sasai Y. (2000). Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28:31\u201340.","journal-title":"Neuron"},{"key":"3_CR2_3","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/76536","volume":"18","author":"S-H Lee","year":"2000","unstructured":"Lee S-H, Lumelsky N, Studer L, Auerbach JM, McKay R. (2000). Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nature Biotechnology 18:675\u20139.","journal-title":"Nature Biotechnology"},{"key":"3_CR3_3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0925-4773(96)00572-2","volume":"59","author":"S Okabe","year":"1996","unstructured":"Okabe S, Forsberg-Nilsson K, Spiro AC, Segal M, McKay RDG. (1996). Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mechanisms of Development 59:89\u2013102.","journal-title":"Mechanisms of Development"},{"key":"3_CR4_3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0925-4773(01)00385-9","volume":"105","author":"A Rolletschek","year":"2001","unstructured":"Rolletschek A, Chang H, Guan KM, Czyz J, Meyer M, Wobus AM. (2001). Differentia-tion of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promo-ting factors. Mechanisms of Development 105:93\u2013104.","journal-title":"Mechanisms of Development"},{"key":"3_CR5_3","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1046\/j.1460-9568.2002.02255.x","volume":"16","author":"S Chung","year":"2002","unstructured":"Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. (2002). Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. European Journal of Neuroscience 16:1829\u201338.","journal-title":"European Journal of Neuroscience"},{"key":"3_CR6_3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.nbd.2004.07.007","volume":"17","author":"C Grothe","year":"2004","unstructured":"Grothe C, Timmer M, Scholz T, Winkler C, Nikkhah G, Claus P, Itoh N, Arenas E. (2004). Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Neurobiology of Disease 17:163\u201370.","journal-title":"Neurobiology of Disease"},{"key":"3_CR7_3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature00900","volume":"418","author":"JH Kim","year":"2002","unstructured":"Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, et al. (2002). Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson\u2019s disease. Nature 418:50\u20136.","journal-title":"Nature"},{"key":"3_CR8_3","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1046\/j.1471-4159.2003.01780.x","volume":"85","author":"JY Kim","year":"2003","unstructured":"Kim JY, Koh HC, Lee JY, Chang MY, Kim YC, Chung HY, Son H, Lee YS, Studer L, et al. (2003). Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression. Journal of Neurochemistry 85:1443\u201354.","journal-title":"Journal of Neurochemistry"},{"key":"3_CR9_3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/10862","volume":"17","author":"J Wagner","year":"1999","unstructured":"Wagner J, Akerud P, Castro DS, Holm PC, Canals JM, Snyder EY, Perlmann T, Arenas E. (1999). Induction of a midbrain dopaminergic phenotype in Nurr1- overexpressing neural stem cells by type 1 astrocytes. Nature Biotechnology 17:653\u20139.","journal-title":"Nature Biotechnology"},{"key":"3_CR10_3","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1634\/stemcells.2006-0386","volume":"25","author":"JA Rodriguez-Gomez","year":"2007","unstructured":"Rodriguez-Gomez JA, Lu JQ, Velasco I, Rivera S, Zoghbi SS, Liow JS, Musachio JL, Chin FT, Toyama H, et al. (2007). Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease. Stem Cells 25:918\u201328.","journal-title":"Stem Cells"},{"key":"3_CR11_3","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/nm1495","volume":"12","author":"NS Roy","year":"2006","unstructured":"Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. (2006). Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature Medicine 12:1259\u201368.","journal-title":"Nature Medicine"},{"key":"3_CR12_3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nm0207-118a","volume":"13","author":"NS Christophersen","year":"2007","unstructured":"Christophersen NS, Brundin P. (2007). Large stem cell grafts could lead to erroneous interpretations of behavioral results?. Nature Medi-cine 13:118; author reply 119.","journal-title":"Nature Medi-cine"},{"key":"3_CR13_3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.brainresbull.2005.08.022","volume":"68","author":"IA Bouhon","year":"2005","unstructured":"Bouhon IA, Kato H, Chandran S, Allen ND. (2005). Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Research Bulletin 15 68:62\u201375.","journal-title":"Brain Research Bulletin 15"},{"key":"3_CR14_3","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1634\/stemcells.2006-0031","volume":"24","author":"IA Bouhon","year":"2006","unstructured":"Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND. (2006). Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells 24:1908\u201313.","journal-title":"Stem Cells"},{"key":"3_CR15_3","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1073\/pnas.022438099","volume":"99","author":"LM Bjorklund","year":"2002","unstructured":"Bjorklund LM, S\u00c2nchez-Pernaute R, Chung S, Andersson T, Ching Chen IY, McNaught KSP, Brownell AL, Jenkins BG, Wahlested C, et al. (2002). Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of National Academy of Science USA 99:2344\u20139.","journal-title":"Proceedings of National Academy of Science USA"},{"key":"3_CR16_3","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/sj.gt.3301771","volume":"9","author":"MU Fareed","year":"2002","unstructured":"Fareed MU, Moolten FL. (2002). Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand \u2013 A fail-safe protection against cellular misbehavior. Gene Therapy 9:955\u201362.","journal-title":"Gene Therapy"},{"key":"3_CR17_3","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1634\/stemcells.21-3-257","volume":"21","author":"M Schuldiner","year":"2003","unstructured":"Schuldiner M, Itskovitz-Eldor J, Benvenisty N. (2003). Selective ablation of human embryonic stem cells expressing a \u201csuicide\u201d gene. Stem Cells21:257\u201365.","journal-title":"Stem Cells"},{"key":"3_CR18_3","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Thakahashi","year":"2006","unstructured":"Thakahashi K, Yamanaka S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663\u2013676.","journal-title":"Cell"},{"key":"3_CR19_3","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861\u2013872.","journal-title":"Cell"},{"key":"3_CR20_3","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin, II, Thomsen JA. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science\n                  318:1917\u20131920.","journal-title":"Science"},{"key":"3_CR21_3","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/jcb.21871","volume":"105","author":"R Zhao","year":"2008","unstructured":"Zhao R, Daley GQ. (2008). From fibroblasts to iPS cells: induced pluripotency by defined factors. J Cell Biochem 105:949\u2013955.","journal-title":"J Cell Biochem"},{"key":"3_CR22_3","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1634\/stemcells.2006-0176","volume":"24","author":"K Cesnulevicius","year":"2006","unstructured":"Cesnulevicius K, Timmer M, Wesemann M, Thomas T, Barkhausen T, Grothe C. (2006). Nucleofection is the most efficient nonviral transfection method for neuronal stem cells derived from ventral mesencephali with no changes in cell composition or dopaminergic fate. Stem Cells 24:2776\u201391.","journal-title":"Stem Cells"},{"key":"3_CR23_3","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.expneurol.2006.12.025","volume":"204","author":"L Anderson","year":"2007","unstructured":"Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA. (2007). Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo. Experiments in Neurology 204:512\u201324.","journal-title":"Experiments in Neurology"},{"key":"3_CR24_3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.expneurol.2006.08.029","volume":"203","author":"HJ Kim","year":"2007","unstructured":"Kim HJ, Sugimori M, Nakafuku M, Svendsen CN. (2007). Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Experiments in Neurology 203:394\u2013405.","journal-title":"Experiments in Neurology"},{"key":"3_CR25_3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1242\/dev.02224","volume":"133","author":"E Andersson","year":"2006","unstructured":"Andersson E, Jensen JB, Parmar M, Guillemot F, Bjorklund A. (2006). Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development 133:507\u201316.","journal-title":"Development"},{"key":"3_CR26_3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1469-7580.2005.00449.x","volume":"207","author":"R Zietlow","year":"2005","unstructured":"Zietlow R, Pekarik V, Armstrong RJ, Tyers P, Dunnett SB, Rosser AE. (2005). The survival of neural precursor cell grafts is influenced by in vitro expansion. Journal of Anatomy 207:227\u201340.","journal-title":"Journal of Anatomy"},{"key":"3_CR27_3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/jnen\/60.8.741","volume":"60","author":"P Hagell","year":"2001","unstructured":"Hagell P, Brundin P. (2001). Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease. Journal of Neuropathology and Experimental Neurology 60:741\u201352.","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"3_CR28_3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0166-2236(96)80038-5","volume":"19","author":"CW Olanow","year":"1996","unstructured":"Olanow CW, Kordower JH, Freeman TB. (1996). Fetal nigral transplantation as a therapy for Parkinson\u2019s disease. Trends in Neurosciences 19:102\u20139.","journal-title":"Trends in Neurosciences"},{"key":"3_CR29_3","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1056\/NEJM200103083441002","volume":"344","author":"CR Freed","year":"2001","unstructured":"Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchiel W, Kao R, Dillon S, Winfield H, Culver S, et al. (2001). Transplantation of embryonic dopamine neurons for severe Parkinson\u2019s disease. The New England Journal of Medicine 344:710\u201319.","journal-title":"The New England Journal of Medicine"},{"key":"3_CR30_3","doi-asserted-by":"publisher","first-page":"13877","DOI":"10.1073\/pnas.97.25.13877","volume":"97","author":"TB Freeman","year":"2000","unstructured":"Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, et al. (2000). Transplanted fetal striatum in Huntington\u2019s disease: Phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences 97:13877\u201382.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"3_CR31_3","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1126\/science.2105529","volume":"247","author":"O Lindvall","year":"1990","unstructured":"Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders KL, Sawle G, Rothwell JC, et al. (1990). Grafts of fetal dopamine neurons survive and improve motor function in Parkinson\u2019s disease. Science 247:574\u20137.","journal-title":"Science"},{"key":"3_CR32_3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn863","volume":"5","author":"P Hagell","year":"2002","unstructured":"Hagell P, Piccine P, Bj\u00f6rklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, et al. (2002). Dyskinesias following neural transplantation in Parkinson\u2019s disease. Nature Neuroscience 5:627\u20138.","journal-title":"Nature Neuroscience"},{"key":"3_CR33_3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1474-4422(06)70381-7","volume":"5","author":"AC Bachoud-Levi","year":"2006","unstructured":"Bachoud-Levi AC, Gaura V, Brugieres P, Lefaucheur JP, Boisse MF, Maison P, Baudic S, Ribeiro MJ, Bourdet C, et al. (2006). Effect of fetal neural transplants in patients with Huntington\u2019s disease 6 years after surgery: A long-term follow-up study. Lancet Neurology 5:303\u20139.","journal-title":"Lancet Neurology"},{"key":"3_CR34_3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/mds.10117","volume":"17","author":"AC Bachoud-Levi","year":"2002","unstructured":"Bachoud-Levi AC, Hantraye P, Peschanski M. (2002). Fetal neural grafts for Huntington\u2019s disease: A prospective view. Movement Disorders 17:439\u201344.","journal-title":"Movement Disorders"},{"key":"3_CR35_3","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1212\/WNL.58.5.687","volume":"58","author":"RA Hauser","year":"2002","unstructured":"Hauser RA, Sandberg PR, Freeman TB, Stoessl AJ. (2002). Bilateral human fetal striatal transplantation in Huntington\u2019s disease. Neurology 58:687\u2013685.","journal-title":"Neurology"},{"key":"3_CR36_3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0079-6123(00)27019-2","volume":"127","author":"TB Freeman","year":"2000","unstructured":"Freeman TB, Hauser RA, Sanberg PR, Saporta S. (2000). Neural transplantation for the treatment of Huntington\u2019s disease. Progress in Brain Research 127:405\u201311.","journal-title":"Progress in Brain Research"},{"key":"3_CR37_3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2165\/00023210-199809020-00001","volume":"9","author":"OV Kopyov","year":"1998","unstructured":"Kopyov OV, Jacques S, Eagle KS. (1998). Fetal transplantation for the treatment of neurodegenerative diseases \u2013 Current status and future potential. CNS Drugs 9:77\u201383.","journal-title":"CNS Drugs"},{"key":"3_CR38_3","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1136\/jnnp.73.6.678","volume":"73","author":"AE Rosser","year":"2002","unstructured":"Rosser AE, Barker RA, Harrower T, Watts C, Farrington M, Ho AK, Burnstein RM, Menon DK, Gillard JH, et al. (2002). Unilateral transplantation of human primary fetal tissue in four patients with Huntington\u2019s disease: NEST-UK safety report ISRCTN no 36485475. Journal of Neurology, Neurosurgery, and Psychiatry 73:678\u201385.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"3_CR39_3","first-page":"147","volume":"50","author":"PW Andrews","year":"1984","unstructured":"Andrews PW, Damjanov I, Simon D, BantingGS, Carlin C, Dracopoli NC, Fogh J. (1984). Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Laboratory Investigation 50:147\u201362.","journal-title":"Differentiation in vivo and in vitro. Laboratory Investigation"},{"key":"3_CR40_3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","volume":"103","author":"D Kondziolka","year":"2005","unstructured":"Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, Decesare S, Jovin T, Zafonte R, et al. (2005). Neurotransplantation for patients with subcortical motor stroke: A phase 2 randomized trial. Journal of Neurosurg 103:38\u201345.","journal-title":"Journal of Neurosurg"},{"key":"3_CR41_3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1212\/WNL.55.4.565","volume":"55","author":"D Kondziolka","year":"2000","unstructured":"Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Gebel J, Jannetta P, DeCesare S, Elder EM, et al. (2000). Transplantation of cultured human neuronal cellsfor patients with stroke. Neurology 22 55:565\u20139.","journal-title":"Neurology 22"},{"key":"3_CR42_3","first-page":"586","volume":"49","author":"CC Meltzer","year":"2001","unstructured":"Meltzer CC, Kondziolka D, Villemagne VL, Wechsler L, Goldstein S, Thulborn KR, Gebel J,Elder EM, DeCesare S, Jacobs A. (2001). Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke. Neurosurgery 49:586\u201391; discussion 91\u20132.","journal-title":"Neurosurgery"},{"key":"3_CR43_3","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/S0002-9440(10)62546-1","volume":"160","author":"PT Nelson","year":"2002","unstructured":"Nelson PT, Kondziolka D, Wechsler L, Goldstein S, Gebel J, DeCesare S, Elder EM, Zhang PJ, Jacobs A, et al. (2002). Clonal human (hNT) neuron grafts for stroke therapy: Neuropathology in a patient 27 months after implantation. The American Journal of Pathology 160:1201\u20136.","journal-title":"The American Journal of Pathology"},{"key":"3_CR44_3","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/ana.20501","volume":"57","author":"OY Bang","year":"2005","unstructured":"Bang OY, Lee JS, Lee PH, Lee G. (2005). Autologous mesenchymal stem cell transplantation in stroke patients. Annals of Neurology 57:874\u201382.","journal-title":"Annals of Neurology"}],"container-title":["Methods in Molecular Biology","Neural Cell Transplantation"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60327-931-4_3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T18:00:06Z","timestamp":1619892006000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-60327-931-4_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9781603279307","9781603279314"],"references-count":44,"URL":"https:\/\/doi.org\/10.1007\/978-1-60327-931-4_3","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2009]]}}}