{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:02:48Z","timestamp":1794366168040,"version":"4.9.0"},"publisher-location":"Totowa, NJ","reference-count":34,"publisher":"Humana Press","isbn-type":[{"value":"9781607612469","type":"print"},{"value":"9781607612476","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-1-60761-247-6_18","type":"book-chapter","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T11:51:30Z","timestamp":1252669890000},"page":"329-345","source":"Crossref","is-referenced-by-count":7,"title":["A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation"],"prefix":"10.1007","author":[{"given":"Paul","family":"Fisher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Brass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,27]]},"reference":[{"issue":"Pt 2","key":"18_CR1","first-page":"157","volume":"132","author":"C. Hedeler","year":"2006","unstructured":"Hedeler, C, Paton, N, Behnke, J, et al. (2006) A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology\n                132(Pt 2): 157\u2013167.","journal-title":"Parasitology"},{"issue":"5","key":"18_CR2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-0038-1634383","volume":"42","author":"J. Mitchell","year":"2003","unstructured":"Mitchell, J, McCray, A, Bodenreider, O. (2003) From phenotype to genotype: issues in navigating the available information resources. Methods Inf Med\n                42(5): 557\u2013563.","journal-title":"Methods Inf Med"},{"key":"18_CR3","doi-asserted-by":"publisher","first-page":"D332","DOI":"10.1093\/nar\/gkj145","volume":"34","author":"K. Liolios","year":"2006","unstructured":"Liolios, K, Tavernarakis, N, Hugenholtz, P, et al. (2006) The Genomes on Line Database (GOLD) v.2: a monitor of genome projects worldwide. Nucleic Acids Res\n                34: D332\u2013D334.","journal-title":"Nucleic Acids Res"},{"issue":"16","key":"18_CR4","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.1093\/nar\/gkm623","volume":"35","author":"P. Fisher","year":"2007","unstructured":"Fisher, P, Hedeler, C, Wolstencroft, K, et al. (2007) A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis. Nucleic Acids Res\n                35(16): 5625\u20135633.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"18_CR5","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/bioinformatics\/btl081","volume":"22","author":"J. K\u00f6hler","year":"2006","unstructured":"K\u00f6hler, J, Baumbach, J, Taubert, J, et al. (2006) Graph-based analysis and visualization of experimental results with ONDEX. Bioinformatics\n                22(11): 1383\u20131390.","journal-title":"Bioinformatics"},{"issue":"6","key":"18_CR6","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"M. Macdonald","year":"1993","unstructured":"Macdonald, M, Ambrose, C, Duyao, M, et al. (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell\n                72(6): 971\u2013983.","journal-title":"Cell"},{"issue":"5602","key":"18_CR7","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1126\/science.1076641","volume":"298","author":"A. Glazier","year":"2002","unstructured":"Glazier, A, Nadeau, J, Aitman, T, (2002) Finding genes that underlie complex traits. Science\n                298(5602): 2345\u20132349.","journal-title":"Science"},{"issue":"1","key":"18_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2156-6-12","volume":"6","author":"A. Brown","year":"2005","unstructured":"Brown, A, Olver, W, Donnelly, C, et al. (2005) Searching QTL by gene expression: analysis of diabesity. BMC Genet\n                6(1): 12\u201320.","journal-title":"BMC Genet"},{"issue":"1","key":"18_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrg703","volume":"3","author":"R. Doerge","year":"2002","unstructured":"Doerge, R. (2002) Mapping and analysis of quantitative trait loci in experimental populations. Nat Rev Genet\n                3(1): 43\u201352.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"18_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1365-2052.2006.01473.x","volume":"37","author":"E. Schadt","year":"2006","unstructured":"Schadt, E. (2006) Novel integrative genomics strategies to identify genes for complex traits. Anim Genet\n                37(1): 18\u201323.","journal-title":"Anim Genet"},{"issue":"1","key":"18_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/bioinformatics\/bth944","volume":"20","author":"R. Stevens","year":"2004","unstructured":"Stevens, R, Tipney, H, Wroe, C, et al. (2004) Exploring Williams-Beuren syndrome using myGrid. Bioinformatics\n                20(1): 303\u2013310.","journal-title":"Bioinformatics"},{"issue":"11","key":"18_CR12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00335-003-2277-9","volume":"14","author":"R. Hitzemann","year":"2003","unstructured":"Hitzemann, R, Malmanger, B, Reed, C, et al. (2003) A strategy for the integration of QTL, gene expression, and sequence analyses. Mamm Genome\n                14(11): 733\u2013747.","journal-title":"Mamm Genome"},{"issue":"4","key":"18_CR13","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrg1576","volume":"6","author":"J. Flint","year":"2005","unstructured":"Flint, J, Valdar, W, Shifman, S, et al. (2005) Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet\n                6(4): 271\u2013286.","journal-title":"Nat Rev Genet"},{"issue":"5","key":"18_CR14","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1021\/bp0400240","volume":"20","author":"Y. Dharmadi","year":"2004","unstructured":"Dharmadi, Y, Gonzalez, R. (2004) DNA microarrays: experimental issues, data analysis, and application to bacterial systems. Biotechnol Prog\n                20(5): 1309\u20131324.","journal-title":"Biotechnol Prog"},{"issue":"11","key":"18_CR15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0168-9525(02)02765-8","volume":"18","author":"D. Kell","year":"2002","unstructured":"Kell, D. (2002) Genotype-phenotype mapping: genes as computer programs. Trends Genet\n                18(11): 555\u2013559.","journal-title":"Trends Genet"},{"issue":"1","key":"18_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/bies.10385","volume":"26","author":"D. Kell","year":"2004","unstructured":"Kell, D, Oliver, S. (2004) Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays\n                26(1): 99\u2013105.","journal-title":"Bioessays"},{"key":"18_CR17","doi-asserted-by":"crossref","unstructured":"Illuminating the black box. Nature 2006, 442(7098): 1.","DOI":"10.1038\/442001a"},{"issue":"5","key":"18_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrg1065","volume":"4","author":"L. Stein","year":"2003","unstructured":"Stein, L. (2003) Integrating biological databases. Nat Rev Genet\n                4(5): 337\u2013345.","journal-title":"Nat Rev Genet"},{"issue":"6885","key":"18_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/417119a","volume":"417","author":"L. Stein","year":"2002","unstructured":"Stein, L. (2002) Creating a bioinformatics nation. Nature\n                417(6885): 119\u2013120.","journal-title":"Nature"},{"key":"18_CR20","doi-asserted-by":"crossref","unstructured":"Oinn, T, Addis, M, Ferris, J, et al. Taverna: a tool for the composition and enactment of bioinformatics workflows. Bioinformatics\n                20(17): 3045\u20133054.","DOI":"10.1093\/bioinformatics\/bth361"},{"key":"18_CR21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/1471-2105-6-225","volume":"6","author":"J. Tomfohr","year":"2005","unstructured":"Tomfohr J, Lu J, Kepler T. (2005) Pathway level analysis of gene expression using singular value decomposition. BMC Bioinformatics\n                6: 225.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"18_CR22","doi-asserted-by":"publisher","first-page":"i212","DOI":"10.1093\/bioinformatics\/btg1028","volume":"19","author":"T. Oinn","year":"2003","unstructured":"Oinn, T (2003) Talisman-rapid application development for the grid. Bioinformatics\n                19(1): i212\u2013i214.","journal-title":"Bioinformatics"},{"key":"18_CR23","doi-asserted-by":"publisher","first-page":"D556\u2013D561","DOI":"10.1093\/nar\/gkj133","volume":"34","author":"E. Birney","year":"2006","unstructured":"Birney, E, Andrews, D, Caccamo, M, et al. (2006) Ensembl 2006. Nucleic Acids Res\n                34: D556\u2013D561.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"18_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M. Kanehisa","year":"2000","unstructured":"Kanehisa, M, Goto, S. (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res\n                28(1): 27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"18_CR25","doi-asserted-by":"publisher","first-page":"D26\u2013D31","DOI":"10.1093\/nar\/gkl993","volume":"35","author":"D. Maglott","year":"2007","unstructured":"Maglott, D, Ostell, J, Pruitt, K, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res\n                35: D26\u2013D31.","journal-title":"Nucleic Acids Res"},{"key":"18_CR26","first-page":"D115\u2013D119","volume":"33","author":"A. Bairoch","year":"2005","unstructured":"Bairoch, A, Apweiler, R, Wu, C, et al. (2005) The Universal Protein Resource (UniProt). Nucleic Acids Res\n                33: D115\u2013D119.","journal-title":"Nucleic Acids Res"},{"issue":"3\u20134","key":"18_CR27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.vetimm.2005.02.004","volume":"105","author":"E. Hill","year":"2005","unstructured":"Hill, E, O'Gorman, G, Agaba, M, et al. (2005) Understanding bovine trypanosomiasis and trypano tolerance: the promise of functional genomics. Vet Immunol Immunopathol\n                105(3\u20134): 247\u2013258.","journal-title":"Vet Immunol Immunopathol"},{"issue":"13","key":"18_CR28","doi-asserted-by":"publisher","first-page":"7443","DOI":"10.1073\/pnas.1232392100","volume":"100","author":"O. Hanotte","year":"2003","unstructured":"Hanotte, O, Ronin, Y, Agaba, M, et al. (2003) Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. Proc Natl Acad Sci USA\n                100(13): 7443\u20137448.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"18_CR29","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s003350010133","volume":"11","author":"F. Iraqi","year":"2000","unstructured":"Iraqi, F, Clapcott, S, Kumari, P, et al. (2000) Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome\n                11(8): 645\u2013648.","journal-title":"Mamm Genome"},{"issue":"2","key":"18_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s00335-004-2314-3","volume":"16","author":"O. Koudand\u00e9","year":"2005","unstructured":"Koudand\u00e9, O, van Arendonk, J, Iraqi, F. (2005) Marker-assisted introgression of trypanotolerance QTL in mice. Mamm Genome\n                16(2): 112\u2013119.","journal-title":"Mamm Genome"},{"issue":"2","key":"18_CR31","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/ng0697-194","volume":"16","author":"S. Kemp","year":"1997","unstructured":"Kemp, S, Iraqi, F, Darvasi, A, et al. (1997) Localization of genes controlling resistance to trypanosomiasis in mice. Nature Genetics\n                16(2): 194\u2013196.","journal-title":"Nature Genetics"},{"issue":"8","key":"18_CR32","first-page":"research0032.00","volume":"2","author":"C. Li","year":"2001","unstructured":"Li, C, Wong, W. (2001) Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol\n                2(8): research0032.0031-research0032.0011.","journal-title":"Genome Biol"},{"issue":"2","key":"18_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"R. Irizarry","year":"2003","unstructured":"Irizarry, R, Hobbs, B, Collin, F, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics\n                4(2): 249\u2013264.","journal-title":"Biostatistics"},{"key":"18_CR34","unstructured":"myExperiment: \n                  http:\/\/myexperiment.org\/\n                  \n                ."}],"container-title":["Methods in Molecular Biology","Cardiovascular Genomics"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60761-247-6_18.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T18:05:00Z","timestamp":1619892300000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-60761-247-6_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9781607612469","9781607612476"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/978-1-60761-247-6_18","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-60761-247-6","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}