{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:00:27Z","timestamp":1772550027746,"version":"3.50.1"},"publisher-location":"Totowa, NJ","reference-count":43,"publisher":"Humana Press","isbn-type":[{"value":"9781607614999","type":"print"},{"value":"9781607615002","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-60761-500-2_12","type":"book-chapter","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T01:48:24Z","timestamp":1267667304000},"page":"187-200","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary Vasoconstriction"],"prefix":"10.1007","author":[{"given":"B.","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gudermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kalwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Grimminger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,12,26]]},"reference":[{"key":"12_CR1_12","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.cardiores.2006.04.009","volume":"71","author":"N Weissmann","year":"2006","unstructured":"Weissmann N, Sommer N, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F (2006) Oxygen sensors in hypoxic pulmonary vasoconstriction. Cardiovasc Res 71:620-629","journal-title":"Cardiovasc Res"},{"key":"12_CR2_12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0034-5687(99)00025-0","volume":"115","author":"JPT Ward","year":"1999","unstructured":"Ward JPT, Aaronson PI (1999) Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right? Respir Physiol 115:261-271","journal-title":"Respir Physiol"},{"key":"12_CR3_12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/cc989","volume":"5","author":"R Naeije","year":"2001","unstructured":"Naeije R, Brimioulle S (2001) Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure. Crit Care 5:67-71","journal-title":"Crit Care"},{"key":"12_CR4_12","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cardiores.2006.04.014","volume":"71","author":"EK Weir","year":"2006","unstructured":"Weir EK, Olschewski A (2006) Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia. Cardiovasc Res 71:630-641","journal-title":"Cardiovasc Res"},{"key":"12_CR5_12","doi-asserted-by":"publisher","first-page":"19093","DOI":"10.1073\/pnas.0606728103","volume":"103","author":"N Weissmann","year":"2006","unstructured":"Weissmann N, Dietrich A, Fuchs B et al (2006) Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A 103:19093-19098","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR6_12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0034-5687(94)00133-K","volume":"100","author":"N Weissmann","year":"1995","unstructured":"Weissmann N, Grimminger F, Walmrath D, Seeger W (1995) Hypoxic vasoconstriction in buffer-perfused rabbit lungs. Respir Physiol 100:159-169","journal-title":"Respir Physiol"},{"key":"12_CR7_12","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1161\/01.RES.0000039065.10754.DE","volume":"91","author":"JSK Sham","year":"2002","unstructured":"Sham JSK (2002) Hypoxic pulmonary vasoconstriction: ups and downs of reactive oxygen species. Circ Res 91:649-651","journal-title":"Circ Res"},{"key":"12_CR8_12","doi-asserted-by":"crossref","first-page":"L314","DOI":"10.1152\/ajplung.2001.281.2.L314","volume":"281","author":"N Weissmann","year":"2001","unstructured":"Weissmann N, Grimminger F, Olschewski A, Seeger W (2001) Hypoxic pulmonary vasoconstriction: a multifactorial response? Am J Physiol Lung Cell Mol Physiol 281:L314-L317","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR9_12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ceca.2007.02.009","volume":"42","author":"A Dietrich","year":"2007","unstructured":"Dietrich A, Kalwa H, Fuchs B, Grimminger F, Weissmann N (2007) Gudermann T. In vivo TRPC functions in the cardiopulmonary vasculature. Cell Calcium 42:233-244","journal-title":"Cell Calcium"},{"key":"12_CR10_12","doi-asserted-by":"crossref","first-page":"L870","DOI":"10.1152\/ajplung.2001.280.5.L870","volume":"280","author":"SS McDaniel","year":"2001","unstructured":"McDaniel SS, Platoshyn O, Wang J et al (2001) Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280:L870-L880","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR11_12","doi-asserted-by":"publisher","first-page":"L848","DOI":"10.1152\/ajplung.00319.2003","volume":"286","author":"J Wang","year":"2004","unstructured":"Wang J, Shimoda LA, Sylvester JT (2004) Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 286:L848-L858","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR12_12","doi-asserted-by":"publisher","first-page":"L2","DOI":"10.1152\/ajplung.00101.2005","volume":"289","author":"JPT Ward","year":"2005","unstructured":"Ward JPT, Robertson TP, Aaronson PI (2005) Capacitative calcium entry: a central role in hypoxic pulmonary vasoconstriction? Am J Physiol Lung Cell Mol Physiol 289:L2-L4","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR13_12","doi-asserted-by":"publisher","first-page":"L1059","DOI":"10.1152\/ajplung.00448.2004","volume":"288","author":"J Wang","year":"2005","unstructured":"Wang J, Shimoda LA, Weigand L, Wang W, Sun D, Sylvester JT (2005) Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol 288:L1059-L1069","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR14_12","doi-asserted-by":"publisher","first-page":"L5","DOI":"10.1152\/ajplung.00044.2005","volume":"289","author":"L Weigand","year":"2005","unstructured":"Weigand L, Foxson J, Wang J, Shimoda LA, Sylvester JT (2005) Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 289:L5-L13","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR15_12","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.pharmthera.2006.05.013","volume":"112","author":"A Dietrich","year":"2006","unstructured":"Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T (2006) Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther 112:744-760","journal-title":"Pharmacol Ther"},{"key":"12_CR16_12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0166-2236(93)90095-4","volume":"16","author":"RC Hardie","year":"1993","unstructured":"Hardie RC, Minke B (1993) Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization. Trends Neurosci 16:371-376","journal-title":"Trends Neurosci"},{"key":"12_CR17_12","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/0896-6273(89)90069-X","volume":"2","author":"C Montell","year":"1989","unstructured":"Montell C, Rubin GM (1989) Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2:1313-1323","journal-title":"Neuron"},{"key":"12_CR18_12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0959-4388(96)80050-X","volume":"6","author":"B Minke","year":"1996","unstructured":"Minke B, Selinger Z (1996) The roles of trp and calcium in regulating photoreceptor function in Drosophila. Curr Opin Neurobiol 6:459-466","journal-title":"Curr Opin Neurobiol"},{"key":"12_CR19_12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0014-5793(95)01038-G","volume":"373","author":"X Zhu","year":"1995","unstructured":"Zhu X, Chu PB, Peyton M, Birnbaumer L (1995) Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett 373:193-198","journal-title":"FEBS Lett"},{"key":"12_CR20_12","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.bbadis.2007.02.009","volume":"1772","author":"AL Firth","year":"2007","unstructured":"Firth AL, Remillard CV, Yuan JX-J (2007) TRP channels in hypertension. Biochim Biophys Acta 1772:895-906","journal-title":"Biochim Biophys Acta"},{"key":"12_CR21_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.18388\/abp.2005_3452","volume":"52","author":"B Targos","year":"2005","unstructured":"Targos B, Ska J, Pomorski P (2005) Store-operated calcium entry in physiology and pathology of mammalian cells. Acta Biochim Pol 52:379-409","journal-title":"Acta Biochim Pol"},{"key":"12_CR22_12","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.bbrc.2004.08.041","volume":"322","author":"M Freichel","year":"2004","unstructured":"Freichel M, Vennekens R, Olausson J et al (2004) Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun 322:1352-1358","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR23_12","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00210-005-1052-8","volume":"371","author":"A Dietrich","year":"2005","unstructured":"Dietrich A, Schnitzler M, Kalwa H, Storch U, Gudermann T (2005) Functional characterization and physiological relevance of the TRPC3\/6\/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol 371:257-265","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"12_CR24_12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1440-1681.2005.04251.x","volume":"32","author":"DJ Beech","year":"2005","unstructured":"Beech DJ (2005) Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol 32:597-603","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"12_CR25_12","doi-asserted-by":"publisher","first-page":"6980","DOI":"10.1128\/MCB.25.16.6980-6989.2005","volume":"25","author":"A Dietrich","year":"2005","unstructured":"Dietrich A, Mederos YS, Gollasch M et al (2005) Increased vascular smooth muscle contractility in TRPC6-\/- mice. Mol Cell Biol 25:6980-6989","journal-title":"Mol Cell Biol"},{"key":"12_CR26_12","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1111\/j.1365-2222.2008.03043.x","volume":"38","author":"S Sel","year":"2008","unstructured":"Sel S, Rost BR, Yildirim AO et al (2008) Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clin Exp Allergy 38:1548-1558","journal-title":"Clin Exp Allergy"},{"key":"12_CR27_12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ceca.2004.02.017","volume":"36","author":"JPT Ward","year":"2004","unstructured":"Ward JPT, Snetkov VA, Aaronson PI (2004) Calcium, mitochondria and oxygen sensing in the pulmonary circulation. Cell Calcium 36:209-220","journal-title":"Cell Calcium"},{"key":"12_CR28_12","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/rr11","volume":"1","author":"M Sweeney","year":"2000","unstructured":"Sweeney M, Yuan JX-J (2000) Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels. Respir Res 1:40-48","journal-title":"Respir Res"},{"key":"12_CR29_12","doi-asserted-by":"crossref","unstructured":"Landsberg JW, Yuan JX-J (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 1944-1950","DOI":"10.1152\/nips.01457.2003"},{"key":"12_CR30_12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1113\/jphysiol.2005.098855","volume":"570","author":"PI Aaronson","year":"2006","unstructured":"Aaronson PI, Robertson TP, Knock GA et al (2006) Hypoxic pulmonary vasoconstriction: mechanisms and controversies. J Physiol 570:53-58","journal-title":"J Physiol"},{"key":"12_CR31_12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1113\/jphysiol.2004.068734","volume":"559","author":"DJ Beech","year":"2004","unstructured":"Beech DJ, Muraki K, Flemming R (2004) Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559:685-706","journal-title":"J Physiol"},{"key":"12_CR32_12","doi-asserted-by":"publisher","first-page":"15195","DOI":"10.1073\/pnas.93.26.15195","volume":"93","author":"L Birnbaumer","year":"1996","unstructured":"Birnbaumer L, Zhu X, Jiang M et al (1996) On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. Proc Natl Acad Sci U S A 93:15195-15202","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR33_12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1165\/ajrcmb.15.5.8918370","volume":"15","author":"C Marshall","year":"1996","unstructured":"Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE (1996) Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Respir Cell Mol Biol 15:633-644","journal-title":"Am J Respir Cell Mol Biol"},{"key":"12_CR34_12","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/hh1201.091960","volume":"88","author":"GB Waypa","year":"2001","unstructured":"Waypa GB, Chandel NS, Schumacker PT (2001) Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 88:1259-1266","journal-title":"Circ Res"},{"key":"12_CR35_12","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1161\/01.RES.0000036751.04896.F1","volume":"91","author":"GB Waypa","year":"2002","unstructured":"Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT (2002) Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 91:719-726","journal-title":"Circ Res"},{"key":"12_CR36_12","doi-asserted-by":"crossref","first-page":"L262","DOI":"10.1152\/ajplung.2000.279.2.L262","volume":"279","author":"JSK Sham","year":"2000","unstructured":"Sham JSK, Crenshaw BR Jr, Deng LH, Shimoda LA, Sylvester JT (2000) Effects of hypoxia in porcine pulmonary arterial myocytes: roles of KV channel and endothelin-1. Am J Physiol Lung Cell Mol Physiol 279:L262-L272","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"12_CR37_12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/expphysiol.1997.sp004052","volume":"82","author":"JL Turner","year":"1997","unstructured":"Turner JL, Kozlowski RZ (1997) Relationship between membrane potential, delayed rectifier K+ currents and hypoxia in rat pulmonary arterial myocytes. Exp Physiol 82:629-645","journal-title":"Exp Physiol"},{"key":"12_CR38_12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1113\/jphysiol.2005.103143","volume":"572","author":"M Estacion","year":"2006","unstructured":"Estacion M, Sinkins WG, Jones SW, Applegate MA, Schilling WP (2006) Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. J Physiol 572:359-377","journal-title":"J Physiol"},{"key":"12_CR39_12","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1126\/stke.2432004pe35","volume":"2004","author":"T Gudermann","year":"2004","unstructured":"Gudermann T, Mederos y Schnitzler M, Dietrich A (2004) Receptor-operated cation entry - more than esoteric terminology? Sci STKE 2004:e35","journal-title":"Sci STKE"},{"key":"12_CR40_12","doi-asserted-by":"publisher","first-page":"39786","DOI":"10.1074\/jbc.M506064200","volume":"280","author":"J Soboloff","year":"2005","unstructured":"Soboloff J, Spassova M, Xu W, He LP, Cuesta N, Gill DL (2005) Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem 280:39786-39794","journal-title":"J Biol Chem"},{"key":"12_CR41_12","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1085\/jgp.70.6.707","volume":"70","author":"RJ French","year":"1977","unstructured":"French RJ, Wells JB (1977) Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon. J Gen Physiol 70:707-724","journal-title":"J Gen Physiol"},{"key":"12_CR42_12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1096\/fj.00-0649fje","volume":"15","author":"SL Archer","year":"2001","unstructured":"Archer SL, London B, Hampl V et al (2001) Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J 15:1801-1803","journal-title":"FASEB J"},{"key":"12_CR43_12","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1096\/fj.08-112821","volume":"22","author":"B Keser\u00fc","year":"2008","unstructured":"Keser\u00fc B, Barbosa-Sicard E, Popp R et al (2008) Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 22:4306-4315","journal-title":"FASEB J"}],"container-title":["Advances in Experimental Medicine and Biology","Membrane Receptors, Channels and Transporters in Pulmonary Circulation"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60761-500-2_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T21:30:02Z","timestamp":1590701402000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-60761-500-2_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,26]]},"ISBN":["9781607614999","9781607615002"],"references-count":43,"URL":"https:\/\/doi.org\/10.1007\/978-1-60761-500-2_12","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12,26]]}}}