{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:40:03Z","timestamp":1794379203061,"version":"4.9.0"},"publisher-location":"Totowa, NJ","reference-count":27,"publisher":"Humana Press","isbn-type":[{"value":"9781607616870","type":"print"},{"value":"9781607616887","type":"electronic"}],"license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-60761-688-7_19","type":"book-chapter","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T13:08:17Z","timestamp":1279544897000},"page":"355-374","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabonomic Studies on Human Hepatocyte in Primary Culture"],"prefix":"10.1007","author":[{"given":"Vincent","family":"Croixmarie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Umbdenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cloarec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Pascussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Boursier-Neyret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,10]]},"reference":[{"key":"19_CR1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B0-08-045044-X\/00125-5","volume-title":"Comprehensive Medicinal Chemistry II","author":"Y. Parmentier","year":"2007","unstructured":"Parmentier, Y., Bossant, M.-J., Bertrand, M., and Walther, B. (2007) In vitro studies of drug metabolism, Comprehensive Medicinal Chemistry II (Taylor, J.B. and Triggle, D.J. eds.), Elsevier, Amsterdam Netherland, pp. 231\u2013257."},{"key":"19_CR2","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1124\/pr.55.4.2","volume":"55","author":"C. Handschin","year":"2003","unstructured":"Handschin, C. and Meyer, U.A. (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacol. Rev. 55, 649\u2013673.","journal-title":"Pharmacol. Rev"},{"key":"19_CR3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2174\/1389200043335397","volume":"5","author":"G. Luo","year":"2004","unstructured":"Luo, G., Guenthner, T., Gan, L.S., and Humphreys, W.G. (2004) CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. Curr. Drug Metab. 5, 483\u2013505.","journal-title":"Curr. Drug Metab"},{"key":"19_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/jbt.20180","volume":"21","author":"L.M.Wallace, A.D Tompkins","year":"2007","unstructured":"Tompkins, L.M. and Wallace, A.D. (2007) Mechanisms of cytochrome P450 induction. J. Biochem. Mol. Toxicol. 21, 176\u2013181.","journal-title":"J. Biochem. Mol. Toxicol"},{"key":"19_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.2133\/dmpk.23.8","volume":"23","author":"Y. Konno","year":"2008","unstructured":"Konno, Y., Negishi, M., and Kodama, S. (2008) The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug. Metab. Pharmacokinet. 23, 8\u201313.","journal-title":"Drug. Metab. Pharmacokinet"},{"key":"19_CR6","doi-asserted-by":"publisher","first-page":"17277","DOI":"10.1074\/jbc.M300138200","volume":"278","author":"J.M. Maglich","year":"2003","unstructured":"Maglich, J.M., Parks, D.J., Moore, L.B., Collins, J.L., Goodwin, B., Billin, A.N., Stoltz, C.A., Kliewer, S.A., Lambert, M.H., Willson, T.M., and Moore, J.T. (2003) Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J. Biol. Chem. 278, 17277\u201317283.","journal-title":"J. Biol. Chem"},{"key":"19_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev.pharmtox.41.1.123","volume":"41","author":"T.Negishi, M Sueyoshi","year":"2001","unstructured":"Sueyoshi, T. and Negishi, M. (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol. 41, 123\u2013143.","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"19_CR8","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1210\/me.2005-0156","volume":"19","author":"J. Orans","year":"2005","unstructured":"Orans, J., Teotico, D.G., and Redinbo, M. (2005) The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Mol. Endocrinol. 19, 2891\u20132900.","journal-title":"Mol. Endocrinol"},{"key":"19_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.pharmtox.47.120505.105349","volume":"48","author":"J.-M. Pascussi","year":"2008","unstructured":"Pascussi, J.-M., Gerbal-Chaloin, S., Duret, C., Daujat-Chavanieu, M., Vilarem, M. J., and Maurel, P. (2008) The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. Annu. Rev. Pharmacol. Toxicol. 48, 1\u201332.","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"19_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1021\/mp700103m","volume":"5","author":"A. Moreau","year":"2008","unstructured":"Moreau, A., Vilarem, M.J., Maurel, P., and Pascussi, J.-M. (2008) Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. Mol. Pharm. 5, 35\u201341.","journal-title":"Mol. Pharm"},{"key":"19_CR11","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"J.K. Nicholson","year":"1999","unstructured":"Nicholson, J.K., Lindon, J.C., and Holmes, E. (1999) \u2018Metabonomics\u2019: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica\n                29, 1181\u20131189.","journal-title":"Xenobiotica"},{"key":"19_CR12","doi-asserted-by":"crossref","unstructured":"Bren, L. (2005) Metabolomics: working toward personalized medicine. FDA\n                Consumer Magazine (November\u2013December Issue) 39(6), 28\u201333.","DOI":"10.1037\/e541912006-005"},{"key":"19_CR13","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1111\/j.1742-4658.2007.05673.x","volume":"274","author":"J.C. Lindon","year":"2007","unstructured":"Lindon, J.C., Holmes, E., and Nicolson, J.K. (2007) Metabonomics in pharmaceutical R&D. FEBS J. 274, 1140\u20131151.","journal-title":"FEBS J"},{"key":"19_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1042\/BA20060221","volume":"47","author":"S.H.Al-Rubeai, M Khoo","year":"2007","unstructured":"Khoo, S.H. and Al-Rubeai, M. (2007) Metabolomics as a complementary tool in cell culture. Biotechnol. Appl. Biochem. 47, 71\u201384.","journal-title":"Biotechnol. Appl. Biochem"},{"key":"19_CR15","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1073\/pnas.81.20.6378","volume":"81","author":"H.C. Isom","year":"1984","unstructured":"Isom, H.C. and Georgoff, I. (1984) Quantitative assay for albumin-producing liver cells after simian virus 40 transformation of rat hepatocytes maintained in chemically defined medium. PNAS\n                81, 6378\u20136382.","journal-title":"PNAS"},{"key":"19_CR16","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nm1202-802","volume":"8","author":"J.T. Brindle","year":"2002","unstructured":"Brindle, J.T., Antti, H., Holmes, E., Tranter, G., Nicholson, J.K., Bethell, H.W., Clarke, S., Schofield, P.M., McKilligin, E., Mosedale, D.E., and Grainger, D.J. (2002) Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat. Med. 8, 1439\u20131444.","journal-title":"Nat. Med"},{"key":"19_CR17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1021\/tx700335d","volume":"21","author":"M. Coen","year":"2008","unstructured":"Coen, M., Holmes, E., Lindon, J.C., and Nicholson J.K. (2008) NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology. Chem. Res. Toxicol. 21, 9\u201327.","journal-title":"Chem. Res. Toxicol"},{"key":"19_CR18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0014-5793(00)02147-5","volume":"484","author":"C.L. Gavaghan","year":"2000","unstructured":"Gavaghan, C.L., Holmes, E., Lenz, E., Wilson, I.D., and Nicholson, J.K. (2000) An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 484, 169\u2013174.","journal-title":"FEBS Lett"},{"key":"19_CR19","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1021\/ac991142i","volume":"72","author":"O. Fiehn","year":"2000","unstructured":"Fiehn, O., Kopka, J., Trethewey, R.N., and Willmitzer, L. (2000) Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Anal. Chem. 72, 3573\u20133580.","journal-title":"Anal. Chem"},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1021\/ac049146x","volume":"77","author":"S. O\u2019Hagan","year":"2005","unstructured":"O\u2019Hagan, S., Dunn, W.B., Brown, M., Knowles, J.D., and Kell, D.B. (2005) Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography\/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. Anal. Chem. 77, 290\u2013303.","journal-title":"Anal. Chem"},{"key":"19_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chroma.2005.05.088","volume":"1086","author":"R.A. Shellie","year":"2005","unstructured":"Shellie, R.A., Welthagen, W., Zrostlikova, J., Spranger, J., Ristow, M., Fiehn, O., and Zimmermann, R. (2005) Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: metabolomic analysis of mouse tissue extracts. J. Chromatogr. A\n                1086, 83\u201390.","journal-title":"J. Chromatogr. A"},{"key":"19_CR22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1021\/pr049769r","volume":"4","author":"I.D. Wilson","year":"2005","unstructured":"Wilson, I.D., Nicholson, J.K., Castro-Perez, J., Granger, J.H., Johnson, K.A., Smith, B.W., and Plumb, R.S. (2005) High resolution \u201cultra performance\u201d liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 4, 591\u2013598.","journal-title":"J. Proteome Res"},{"key":"19_CR23","doi-asserted-by":"publisher","first-page":"7278","DOI":"10.1021\/ac060935j","volume":"78","author":"R.S. Plumb","year":"2006","unstructured":"Plumb, R.S., Rainville, P., Smith, B.W., Johnson, K.A., Castro-Perez, J., Wilson, I.D., and Nicholson, J.K. (2006) Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities. Anal. Chem. 78, 7278\u20137283.","journal-title":"Anal. Chem"},{"key":"19_CR24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1021\/pr060505+","volume":"6","author":"E.J. Want","year":"2007","unstructured":"Want, E.J., Nordstr\u00f6m, A., Morita, H., and Siuzdak, G. (2007) From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J. Proteome Res. 6, 459\u2013468.","journal-title":"J. Proteome Res"},{"key":"19_CR25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1021\/ac0713510","volume":"80","author":"S. Wiklund","year":"2008","unstructured":"Wiklund, S., Johansson, E., Sj\u00f6str\u00f6m, L., Mellerowicz, E.J., Edlund, U., Shockcor, J.P., Gottfries, J., Moritz, T., and Trygg, J. (2008) Visualization of GC\/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 80, 115\u2013122.","journal-title":"Anal. Chem"},{"key":"19_CR26","first-page":"283","volume":"320","author":"L. Pichard","year":"2006","unstructured":"Pichard, L., Raulet, E., Fabre, G., Ferrini, J.B., Ourlin, J.C., and Maurel, P. (2006) Human hepatocyte culture. Methods Mol. Biol. 320, 283\u2013293.","journal-title":"Methods Mol. Biol"},{"key":"19_CR27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.chroma.2007.04.021","volume":"1158","author":"M. Katajamaa","year":"2007","unstructured":"Katajamaa, M. and Oresic, M. (2007) Data processing for mass spectrometry-based metabolomics. J. Chromatogr. A\n                1158, 318\u2013328.","journal-title":"J. Chromatogr. A"}],"container-title":["Methods in Molecular Biology","Hepatocytes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60761-688-7_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T17:48:48Z","timestamp":1675705728000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-60761-688-7_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"ISBN":["9781607616870","9781607616887"],"references-count":27,"URL":"https:\/\/doi.org\/10.1007\/978-1-60761-688-7_19","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-60761-688-7","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]},"assertion":[{"value":"10 February 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}