{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:03:27Z","timestamp":1784333007623,"version":"3.55.0"},"publisher-location":"Totowa, NJ","reference-count":76,"publisher":"Humana Press","isbn-type":[{"value":"9781607618027","type":"print"},{"value":"9781607618034","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-60761-803-4_9","type":"book-chapter","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T15:56:36Z","timestamp":1278604596000},"page":"229-240","source":"Crossref","is-referenced-by-count":55,"title":["Antithrombotic Effects of Naturally Derived Products on Coagulation and Platelet Function"],"prefix":"10.1007","author":[{"given":"Shaker A.","family":"Mousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,10]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/BF03043926","volume":"24","author":"A. Gaede","year":"1999","unstructured":"Gaede, A., and Terres, W. (1999) Therapy of acute coronary syndrome. Aspirin, heparin, low-molecular-weight heparin, hirudin and GP-IIb\/IIIa blockers Herz 24, 353\u201362.","journal-title":"Herz."},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1046\/j.1525-1594.2000.06348.x","volume":"24","author":"S.C. Vasudev","year":"2000","unstructured":"Vasudev, S.C., Chandy, T., Sharma, C.P., Mohanty, M., and Umasankar, P.R. (2000) Synergistic effect of released aspirin\/heparin for preventing bovine pericardial calcification Artif Organs 24, 129\u201336.","journal-title":"Artif Organs"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0735-1097(00)01135-9","volume":"37","author":"D. Massel","year":"2001","unstructured":"Massel, D., and Little, S.H. (2001) Risks and benefits of adding anti-platelet therapy to warfarin among patients with prosthetic heart valves: a meta-analysis J Am Coll Cardiol 37, 569\u201378.","journal-title":"J Am Coll Cardiol."},{"issue":"3","key":"9_CR4","first-page":"S710","volume":"84","author":"P. Akarasereenont","year":"2001","unstructured":"Akarasereenont, P., Chotewuttakorn, S., Aiamsa-Ard, T., and Thaworn, A. (2001) The activation of platelet aggregation by human cholangiocarcinoma cells is mediated through thrombin receptor J Med Assoc Thai 84(Suppl 3), S710\u201321.","journal-title":"J Med Assoc Thai."},{"key":"9_CR5","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/S0049-3848(98)00161-3","volume":"92","author":"J.P. Biggerstaff","year":"1998","unstructured":"Biggerstaff, J.P., Seth, N.B., Meyer, T.V., Amirkhosravi, A., and Francis, J.L. (1998) Fibrin monomer increases platelet adherence to tumor cells in a flowing system: a possible role in metastasis? Thromb Res 92, S53\u20138.","journal-title":"Thromb Res."},{"key":"9_CR6","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1089\/152308601317203567","volume":"3","author":"K.P.L. Bhat","year":"2001","unstructured":"Bhat, K.P.L., Kosmeder, J.W., 2nd, and Pezzuto, J.M. (2001) Biological effects of resveratrol Antioxid Redox Signal 3, 1041\u201364.","journal-title":"Antioxid Redox Signal"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0049-3848(02)00273-6","volume":"107","author":"B. Olas","year":"2002","unstructured":"Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. (2002) Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin Thromb Res 107, 141\u20135.","journal-title":"Thromb Res."},{"key":"9_CR8","first-page":"378","volume":"115","author":"Z. Wang","year":"2002","unstructured":"Wang, Z., Zou, J., Huang, Y., Cao, K., Xu, Y., and Wu, J.M. (2002) Effect of resveratrol on platelet aggregation in vivo and in vitro Chin Med J (Engl) 115, 378\u201380.","journal-title":"Chin Med J (Engl)"},{"issue":"9B","key":"9_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0002-9343(01)00995-0","volume":"113","author":"P.M. Kris-Etherton","year":"2002","unstructured":"Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Hilpert, K.F., Griel, A.E., and Etherton, T.D. (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer Am J Med 113(Suppl 9B), 71\u201388S.","journal-title":"Am J Med."},{"key":"9_CR10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1055\/s-0037-1613474","volume":"89","author":"R. Deana","year":"2003","unstructured":"Deana, R., Turetta, L., Donella-Deana, A., Dona, M., Brunati, A.M., De Michiel, L., and Garbisa, S. (2003) Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists Thromb Haemost 89, 866\u201374.","journal-title":"Thromb Haemost."},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/00005344-200112000-00009","volume":"38","author":"W.S. Kang","year":"2001","unstructured":"Kang, W.S., Chung, K.H., Chung, J.H., Lee, J.Y., Park, J.B., Zhang, Y.H., Yoo, H.S., and Yun, Y.P. (2001) Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase J Cardiovasc Pharmacol 38, 875\u201384.","journal-title":"J Cardiovasc Pharmacol."},{"key":"9_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0049-3848(99)00104-8","volume":"96","author":"W.S. Kang","year":"1999","unstructured":"Kang, W.S., Lim, I.H., Yuk, D.Y., Chung, K.H., Park, J.B., Yoo, H.S., and Yun, Y.P. (1999) Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate Thromb Res 96, 229\u201337.","journal-title":"Thromb Res."},{"key":"9_CR13","first-page":"397","volume":"16","author":"A. Kazi","year":"2002","unstructured":"Kazi, A., Smith, D.M., Daniel, K., Zhong, S., Gupta, P., Bosley, M.E., and Dou, Q.P. (2002) Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention In Vivo 16, 397\u2013403.","journal-title":"In Vivo."},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0014-5793(00)01360-0","volume":"471","author":"A. Sachinidis","year":"2000","unstructured":"Sachinidis, A., Seul, C., Seewald, S., Ahn, H., Ko, Y., and Vetter, H. (2000) Green tea compounds inhibit tyrosine phosphorylation of PDGF beta-receptor and transformation of A172 human glioblastoma FEBS Lett 471, 51\u20135.","journal-title":"FEBS Lett."},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0952-3278(90)90050-U","volume":"40","author":"M. Ali","year":"1990","unstructured":"Ali, M., Afzal, M., Gubler, C.J., and Burka, J.F. (1990) A potent thromboxane formation inhibitor in green tea leaves Prostaglandins Leukot Essent Fatty Acids 40, 281\u20133.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1079\/BJN2001499","volume":"87","author":"J.M. Hodgson","year":"2002","unstructured":"Hodgson, J.M., Puddey, I.B., Burke, V., Beilin, L.J., Mori, T.A., and Chan, S.Y. (2002) Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects Br J Nutr 87, 141\u20135.","journal-title":"Br J Nutr."},{"key":"9_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0014-2999(02)02449-4","volume":"455","author":"K. Kondo","year":"2002","unstructured":"Kondo, K., Suzuki, Y., Ikeda, Y., and Umemura, K. (2002) Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation Eur J Pharmacol 455, 53\u20137.","journal-title":"Eur J Pharmacol."},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0006-2952(93)90515-X","volume":"46","author":"Y. Ozaki","year":"1993","unstructured":"Ozaki, Y., Yatomi, Y., Jinnai, Y., and Kume, S. (1993) Effects of genistein, a tyrosine kinase inhibitor, on platelet functions. Genistein attenuates thrombin-induced Ca2+ mobilization in human platelets by affecting polyphosphoinositide turnover Biochem Pharmacol 46, 395\u2013403.","journal-title":"Biochem Pharmacol."},{"key":"9_CR19","first-page":"540","volume":"19","author":"W. Liu","year":"1998","unstructured":"Liu, W., Song, Z.J., and Liang, N.C. (1998) Effects of genistein on aggregation and cytosolic free calcium in pig platelets Zhongguo Yao Li Xue Bao 19, 540\u20132.","journal-title":"Zhongguo Yao Li Xue Bao."},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0952-3278(93)90118-G","volume":"48","author":"A. McNicol","year":"1993","unstructured":"McNicol, A. (1993) The effects of genistein on platelet function are due to thromboxane receptor antagonism rather than inhibition of tyrosine kinase Prostaglandins Leukot Essent Fatty Acids 48, 379\u201384.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9_CR21","first-page":"29","volume":"12","author":"S.R. Chinni","year":"2003","unstructured":"Chinni, S.R., Alhasan, S.A., Multani, A.S., Pathak, S., and Sarkar, F.H. (2003) Pleotropic effects of genistein on MCF-7 breast cancer cells Int J Mol Med 12, 29\u201334.","journal-title":"Int J Mol Med."},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1349-7006.2003.tb01422.x","volume":"94","author":"H. Myoung","year":"2003","unstructured":"Myoung, H., Hong, S.P., Yun, P.Y., Lee, J.H., and Kim, M.J. (2003) Anti-cancer effect of genistein in oral squamous cell carcinoma with respect to angiogenesis and in vitro invasion Cancer Sci 94, 215\u201320.","journal-title":"Cancer Sci."},{"key":"9_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0167-4889(00)00061-6","volume":"1497","author":"M.A. Belisario","year":"2000","unstructured":"Belisario, M.A., Tafuri, S., Di Domenico, C., Della Morte, R., Squillacioti, C., Lucisano, A., and Staiano, N. (2000) Immobilised echistatin promotes platelet adhesion and protein tyrosine phosphorylation Biochim Biophys Acta 1497, 227\u201336.","journal-title":"Biochim Biophys Acta."},{"key":"9_CR24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0022-3565(24)37071-5","volume":"283","author":"C.C. Kumar","year":"1997","unstructured":"Kumar, C.C., Nie, H., Rogers, C.P., Malkowski, M., Maxwell, E., Catino, J.J., and Armstrong, L. (1997) Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor J Pharmacol Exp Ther 283, 843\u201353.","journal-title":"J Pharmacol Exp Ther."},{"key":"9_CR25","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0300-9084(97)86935-0","volume":"79","author":"N. Staiano","year":"1997","unstructured":"Staiano, N., Della Morte, R., Di Domenico, C., Tafuri, S., Squillacioti, C., Belisario, M.A., and Di Natale, P. (1997) Echistatin inhibits pp72syk and pp125FAK phosphorylation in fibrinogen-adherent platelets Biochimie 79, 769\u201373.","journal-title":"Biochimie."},{"key":"9_CR26","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1182\/blood.V93.8.2605","volume":"93","author":"L. Tan","year":"1999","unstructured":"Tan, L., Kowalska, M.A., Romo, G.M., Lopez, J.A., Darzynkiewicz, Z., and Niewiarowski, S. (1999) Identification and characterization of endothelial glycoprotein Ib using viper venom proteins modulating cell adhesion Blood 93, 2605\u201316.","journal-title":"Blood"},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/PL00004970","volume":"355","author":"P.J. Chiu","year":"1997","unstructured":"Chiu, P.J., Vemulapalli, S., Chintala, M., Kurowski, S., Tetzloff, G.G., Brown, A.D., and Sybertz, E.J. (1997) Inhibition of platelet adhesion and aggregation by E4021, a type V phosphodiesterase inhibitor, in guinea pigs Naunyn Schmiedeberg\u2019s Arch Pharmacol 355, 463\u20139.","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol."},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.1046\/j.1432-1327.2000.01561.x","volume":"267","author":"R. Della Morte","year":"2000","unstructured":"Della Morte, R., Squillacioti, C., Garbi, C., Derkinderen, P., Belisario, M.A., Girault, J.A., Di Natale, P., Nitsch, L., and Staiano, N. (2000) Echistatin inhibits pp125FAK autophosphorylation, paxillin phosphorylation and pp125FAK-paxillin interaction in fibronectin-adherent melanoma cells Eur J Biochem 267, 5047\u201354.","journal-title":"Eur J Biochem."},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/abio.1993.1149","volume":"210","author":"R.N. Puri","year":"1993","unstructured":"Puri, R.N., and Colman, R.W. (1993) Thrombin- and cathepsin G-induced platelet aggregation: effect of protein kinase C inhibitors Anal Biochem 210, 50\u20137.","journal-title":"Anal Biochem."},{"key":"9_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0049-3848(91)90208-E","volume":"64","author":"S.H. Tzeng","year":"1991","unstructured":"Tzeng, S.H., Ko, W.C., Ko, F.N., and Teng, C.M. (1991) Inhibition of platelet aggregation by some flavonoids Thromb Res 64, 91\u2013100.","journal-title":"Thromb Res."},{"key":"9_CR31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0950-351X(98)80009-8","volume":"12","author":"T. Fotsis","year":"1998","unstructured":"Fotsis, T., Pepper, M.S., Montesano, R., Aktas, E., Breit, S., Schweigerer, L., Rasku, S., Wahala, K., and Adlercreutz, H. (1998) Phytoestrogens and inhibition of angiogenesis Baillieres Clin Endocrinol Metab 12, 649\u201366.","journal-title":"Baillieres Clin Endocrinol Metab."},{"key":"9_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0006-2952(01)00876-0","volume":"63","author":"W.R. Lee","year":"2002","unstructured":"Lee, W.R., Shen, S.C., Lin, H.Y., Hou, W.C., Yang, L.L., and Chen, Y.C. (2002) Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease Biochem Pharmacol 63, 225\u201336.","journal-title":"Biochem Pharmacol."},{"key":"9_CR33","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1055\/s-2006-960120","volume":"57","author":"G. Blania","year":"1991","unstructured":"Blania, G., and Spangenberg, B. (1991) Formation of allicin from dried garlic (Allium sativum): a simple HPTLC method for simultaneous determination of allicin and ajoene in dried garlic and garlic preparations Planta Med 57, 371\u20135.","journal-title":"Planta Med."},{"key":"9_CR34","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/BF01966468","volume":"29","author":"A.N. Makheja","year":"1990","unstructured":"Makheja, A.N., and Bailey, J.M. (1990) Antiplatelet constituents of garlic and onion Agents Actions 29, 360\u20133.","journal-title":"Agents Actions"},{"key":"9_CR35","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/BF01969110","volume":"25","author":"P.R. Mayeux","year":"1988","unstructured":"Mayeux, P.R., Agrawal, K.C., Tou, J.S., King, B.T., Lippton, H.L., Hyman, A.L., Kadowitz, P.J., and McNamara, D.B. (1988) The pharmacological effects of allicin, a constituent of garlic oil Agents Actions 25, 182\u201390.","journal-title":"Agents Actions"},{"key":"9_CR36","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/0006-2952(89)90339-0","volume":"38","author":"F. Rendu","year":"1989","unstructured":"Rendu, F., Daveloose, D., Debouzy, J.C., Bourdeau, N., Levy-Toledano, S., Jain, M.K., and Apitz-Castro, R. (1989) Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity Biochem Pharmacol 38, 1321\u20138.","journal-title":"Biochem Pharmacol."},{"key":"9_CR37","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0952-3278(93)90165-S","volume":"49","author":"K.C. Srivastava","year":"1993","unstructured":"Srivastava, K.C., and Tyagi, O.D. (1993) Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets Prostaglandins Leukot Essent Fatty Acids 49, 587\u201395.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1207\/S15327914NC382_14","volume":"38","author":"K. Hirsch","year":"2000","unstructured":"Hirsch, K., Danilenko, M., Giat, J., Miron, T., Rabinkov, A., Wilchek, M., Mirelman, D., Levy, J., and Sharoni, Y. (2000) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation Nutr Cancer 38, 245\u201354.","journal-title":"Nutr Cancer"},{"key":"9_CR39","first-page":"3519","volume":"21","author":"N. Ahmed","year":"2001","unstructured":"Ahmed, N., Laverick, L., Sammons, J., Zhang, H., Maslin, D.J., and Hassan, H.T. (2001) Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells Anticancer Res 21, 3519\u201323.","journal-title":"Anticancer Res."},{"key":"9_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0952-3278(98)90034-5","volume":"58","author":"A. Bordia","year":"1998","unstructured":"Bordia, A., Verma, S.K., and Srivastava, K.C. (1998) Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease Prostaglandins Leukot Essent Fatty Acids 58, 257\u201363.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9_CR41","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1016\/S0006-2952(00)00467-6","volume":"60","author":"R. Qi","year":"2000","unstructured":"Qi, R., Liao, F., Inoue, K., Yatomi, Y., Sato, K., and Ozaki, Y. (2000) Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca(2+) mobilization without affecting inositol-1,4, 5-trisphosphate (IP(3)) formation in activated platelets Biochem Pharmacol 60, 1475\u201383.","journal-title":"Biochem Pharmacol."},{"key":"9_CR42","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1089\/104454902320908423","volume":"21","author":"Y. Li","year":"2002","unstructured":"Li, Y., and Lu, Y.Y. (2002) Isolation of diallyl trisulfide inducible differentially expressed genes in human gastric cancer cells by modified cDNA representational difference analysis DNA Cell Biol 21, 771\u201380.","journal-title":"DNA Cell Biol."},{"key":"9_CR43","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/BF02886798","volume":"14","author":"Z.H. Feng","year":"1994","unstructured":"Feng, Z.H., Zhang, G.M., Hao, T.L., Zhou, B., Zhang, H., and Jiang, Z.Y. (1994) Effect of diallyl trisulfide on the activation of T cell and macrophage-mediated cytotoxicity J Tongji Med Univ 14, 142\u20137.","journal-title":"J Tongji Med Univ."},{"key":"9_CR44","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jn\/131.2.374S","volume":"131","author":"J.E. Freedman","year":"2001","unstructured":"Freedman, J.E., and Keaney, J.F., Jr. (2001) Vitamin E inhibition of platelet aggregation is independent of antioxidant activity J Nutr 131, 374\u20137S.","journal-title":"J Nutr."},{"key":"9_CR45","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1753-4887.1999.tb06903.x","volume":"57","author":"M. Steiner","year":"1999","unstructured":"Steiner, M. (1999) Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease Nutr Rev 57, 306\u20139.","journal-title":"Nutr Rev."},{"key":"9_CR46","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0021-9150(99)00169-0","volume":"147","author":"L. Mabile","year":"1999","unstructured":"Mabile, L., Bruckdorfer, K.R., and Rice-Evans, C. (1999) Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation Atherosclerosis 147, 177\u201385.","journal-title":"Atherosclerosis"},{"key":"9_CR47","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/07315724.1991.10718173","volume":"10","author":"M. Steiner","year":"1991","unstructured":"Steiner, M. (1991) Influence of vitamin E on platelet function in humans J Am Coll Nutr 10, 466\u201373.","journal-title":"J Am Coll Nutr."},{"key":"9_CR48","first-page":"513","volume":"51","author":"H.M. Zbikowska","year":"2000","unstructured":"Zbikowska, H.M., and Olas, B. (2000) Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion J Physiol Pharmacol 51, 513\u201320.","journal-title":"J Physiol Pharmacol."},{"key":"9_CR49","unstructured":"Suttuar, J., Masova, L., and Scheiner, T. (2002) Role of free radicals in blood platelet activation Cas Lek Cesk 141(Suppl.)"},{"key":"9_CR50","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0049-3848(90)90233-3","volume":"60","author":"E. Kakishita","year":"1990","unstructured":"Kakishita, E., Suehiro, A., Oura, Y., and Nagai, K. (1990) Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood Thromb Res 60, 489\u201399.","journal-title":"Thromb Res."},{"key":"9_CR51","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0262-1746(87)90036-9","volume":"26","author":"J.L. Toivanen","year":"1987","unstructured":"Toivanen, J.L. (1987) Effects of selenium, vitamin E and vitamin C on human prostacyclin and thromboxane synthesis in vitro Prostaglandins Leukot Med 26, 265\u201380.","journal-title":"Prostaglandins Leukot Med."},{"key":"9_CR52","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/09537100120071022","volume":"12","author":"I. Bakaltcheva","year":"2001","unstructured":"Bakaltcheva, I., Gyimah, D., and Reid, T. (2001) Effects of alpha-tocopherol on platelets and the coagulation system Platelets 12, 389\u201394.","journal-title":"Platelets."},{"key":"9_CR53","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1515\/BC.2002.048","volume":"383","author":"R. Ricciarelli","year":"2002","unstructured":"Ricciarelli, R., Zingg, J.M., and Azzi, A. (2002) The 80th anniversary of vitamin E: beyond its antioxidant properties Biol Chem 383, 457\u201365.","journal-title":"Biol Chem."},{"key":"9_CR54","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0306-9877(86)90109-X","volume":"19","author":"M.F. McCarty","year":"1986","unstructured":"McCarty, M.F. (1986) An antithrombotic role for nutritional antioxidants: implications for tumor metastasis and other pathologies Med Hypotheses 19, 345\u201357.","journal-title":"Med Hypotheses."},{"key":"9_CR55","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S0006-291X(03)00223-7","volume":"302","author":"C.M. Corl","year":"2003","unstructured":"Corl, C.M., Cao, Y.Z., Cohen, Z.S., and Sordillo, L.M. (2003) Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells Biochem Biophys Res Commun 302, 610\u20134.","journal-title":"Biochem Biophys Res Commun."},{"key":"9_CR56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0005-2760(89)90189-6","volume":"1006","author":"G. Hampel","year":"1989","unstructured":"Hampel, G., Watanabe, K., Weksler, B.B., and Jaffe, E.A. (1989) Selenium deficiency inhibits prostacyclin release and enhances production of platelet activating factor by human endothelial cells Biochim Biophys Acta 1006, 151\u20138.","journal-title":"Biochim Biophys Acta."},{"key":"9_CR57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-0038-1647308","volume":"64","author":"G. Perona","year":"1990","unstructured":"Perona, G., Schiavon, R., Guidi, G.C., Veneri, D., and Minuz, P. (1990) Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function Thromb Haemost 64, 312\u20138.","journal-title":"Thromb Haemost."},{"key":"9_CR58","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s005990050068","volume":"29","author":"M.M. Ricetti","year":"1999","unstructured":"Ricetti, M.M., Guidi, G.C., Tecchio, C., Bellisola, G., Rigo, A., and Perona, G. (1999) Effects of sodium selenite on in vitro interactions between platelets and endothelial cells Int J Clin Lab Res 29, 80\u20134.","journal-title":"Int J Clin Lab Res."},{"key":"9_CR59","first-page":"181","volume":"54","author":"D. Vitoux","year":"1996","unstructured":"Vitoux, D., Chappuis, P., Arnaud, J., Bost, M., Accominotti, M., and Roussel, A.M. (1996) Selenium, glutathione peroxidase, peroxides and platelet functions Ann Biol Clin (Paris) 54, 181\u20137.","journal-title":"Ann Biol Clin (Paris)"},{"key":"9_CR60","first-page":"629","volume":"93","author":"A. Brtkova","year":"1992","unstructured":"Brtkova, A. (1992) Biological effects of selenium Bratisl Lek Listy 93, 629\u201332.","journal-title":"Bratisl Lek Listy"},{"key":"9_CR61","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/BF02592283","volume":"23","author":"A. Costa","year":"1993","unstructured":"Costa, A., Sacchini, V., and Decensi, A. (1993) Retinoids and tamoxifen in breast cancer chemoprevention Int J Clin Lab Res 23, 53\u20135.","journal-title":"Int J Clin Lab Res."},{"key":"9_CR62","first-page":"22","volume":"7","author":"S. Parcell","year":"2002","unstructured":"Parcell, S. (2002) Sulfur in human nutrition and applications in medicine Altern Med Rev 7, 22\u201344.","journal-title":"Altern Med Rev."},{"key":"9_CR63","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/107555302317371451","volume":"8","author":"E. Barrager","year":"2002","unstructured":"Barrager, E., Veltmann, J.R., Jr., Schauss, A.G., and Schiller, R.N. (2002) A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis J Altern Complement Med 8, 167\u201373.","journal-title":"J Altern Complement Med."},{"key":"9_CR64","first-page":"453","volume":"23","author":"K. Ebisuzaki","year":"2003","unstructured":"Ebisuzaki, K. (2003) Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention Anticancer Res 23, 453\u20138.","journal-title":"Anticancer Res."},{"key":"9_CR65","unstructured":"Thrombosis prevention \u2013 disease therapies protocol. Life extension (Accessed at http:\/\/www.lef.org\/protocols\/prtcl-155.shtml .)"},{"key":"9_CR66","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0049-3848(85)90178-1","volume":"38","author":"D. Baruch","year":"1985","unstructured":"Baruch, D., Franssen, J., Hemker, H.C., and Lindhout, T. (1985) Effect of heparin and low molecular weight heparins on thrombin-induced blood platelet activation in the absence of antithrombin III Thromb Res 38, 447\u201358.","journal-title":"Thromb Res."},{"key":"9_CR67","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1055\/s-0037-1614962","volume":"79","author":"E. Marsh Lyle","year":"1998","unstructured":"Marsh Lyle, E., Lewis, S.D., Lehman, E.D., Gardell, S.J., Motzel, S.L., and Lynch, J.J., Jr. (1998) Assessment of thrombin inhibitor efficacy in a novel rabbit model of simultaneous arterial and venous thrombosis Thromb Haemost 79, 656\u201362.","journal-title":"Thromb Haemost"},{"key":"9_CR68","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1111\/j.1349-7006.1992.tb02726.x","volume":"83","author":"S. Atagi","year":"1992","unstructured":"Atagi, S., Sone, S., Fukuta, K., and Ogura, T. (1992) Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells Jpn J Cancer Res 83, 1088\u201394.","journal-title":"Jpn J Cancer Res."},{"key":"9_CR69","doi-asserted-by":"publisher","first-page":"V275","DOI":"10.1016\/S0049-3848(02)00093-2","volume":"106","author":"J.I. Weitz","year":"2002","unstructured":"Weitz, J.I., and Crowther, M. (2002) Direct thrombin inhibitors Thromb Res 106, V275\u201384.","journal-title":"Thromb Res."},{"key":"9_CR70","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2165\/00002018-199717050-00005","volume":"17","author":"T.E. Warkentin","year":"1997","unstructured":"Warkentin, T.E. (1997) Heparin-induced thrombocytopenia. Pathogenesis, frequency, avoidance and management Drug Saf 17, 325\u201341.","journal-title":"Drug Saf."},{"key":"9_CR71","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1055\/s-2002-35292","volume":"28","author":"F. Markwardt","year":"2002","unstructured":"Markwardt, F. (2002) Hirudin as alternative anticoagulant \u2013 a historical review Semin Thromb Hemost 28, 405\u201314.","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"9_CR72","first-page":"22","volume":"27","author":"M.C. Guillin","year":"1998","unstructured":"Guillin, M.C. (1998) Thrombin and its pharmacologic regulation Presse Med 27 (Suppl 2), 22\u20137.","journal-title":"Presse Med."},{"key":"9_CR73","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2174\/1568006013338123","volume":"1","author":"G.X. Shen","year":"2001","unstructured":"Shen, G.X. (2001) Development and current applications of thrombin-specific inhibitors Curr Drug Targets Cardiovasc Haematol Disord 1, 41\u20139.","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"key":"9_CR74","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.2165\/00003495-200262130-00001","volume":"62","author":"J.W. Eikelboom","year":"2002","unstructured":"Eikelboom, J.W., and French, J. (2002) Management of patients with acute coronary syndromes: what is the clinical role of direct thrombin inhibitors? Drugs 62, 1839\u201352.","journal-title":"Drugs"},{"key":"9_CR75","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1161\/01.CIR.95.4.800","volume":"95","author":"C. Bode","year":"1997","unstructured":"Bode, C., Hanson, S.R., Schmedtje, J.F., Jr., Haber, E., Mehwald, P., Kelly, A.B., Harker, L.A., and Runge, M.S. (1997) Antithrombotic potency of hirudin is increased in nonhuman primates by fibrin targeting Circulation 95, 800\u20134.","journal-title":"Circulation"},{"key":"9_CR76","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1161\/01.ATV.19.5.1348","volume":"19","author":"J.P. Bossavy","year":"1999","unstructured":"Bossavy, J.P., Sakariassen, K.S., Rubsamen, K., Thalamas, C., Boneu, B., and Cadroy, Y. (1999) Comparison of the antithrombotic effect of PEG-hirudin and heparin in a human ex vivo model of arterial thrombosis Arterioscler Thromb Vasc Biol 19, 1348\u201353.","journal-title":"Arterioscler Thromb Vasc Biol."}],"container-title":["Methods in Molecular Biology","Anticoagulants, Antiplatelets, and Thrombolytics"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-60761-803-4_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T19:40:16Z","timestamp":1740253216000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-60761-803-4_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"ISBN":["9781607618027","9781607618034"],"references-count":76,"URL":"https:\/\/doi.org\/10.1007\/978-1-60761-803-4_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}