{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:07:13Z","timestamp":1773151633189,"version":"3.50.1"},"publisher-location":"Totowa, NJ","reference-count":21,"publisher":"Humana Press","isbn-type":[{"value":"9781617792038","type":"print"},{"value":"9781617792045","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/978-1-61779-204-5_9","type":"book-chapter","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T18:15:51Z","timestamp":1311963351000},"page":"191-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Molecular Biology of Furin-Like Proprotein Convertases in Vascular Remodelling"],"prefix":"10.1007","author":[{"given":"Philipp","family":"Stawowy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Kappert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1056\/NEJMsa053935","volume":"356","author":"E. S. Ford","year":"2007","unstructured":"Ford, E. S., Ajani, U. A., Croft, J. B., Critchley, J. A., Labarthe, D. R., Kottke, T. E., Giles, W. H., and Capewell, S. (2007) Explaining the decrease in US deaths from coronary disease, 1980\u20132000 N Engl J Med\n                  356, 2388\u201398.","journal-title":"N Engl J Med"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.108.191261","volume":"119","author":"D. Lloyd-Jones","year":"2009","unstructured":"Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., Greenlund, K., Haase, N., Hailpern, S., Ho, M., Howard, V., Kissela, B., Kittner, S., Lackland, D., Lisabeth, L., Marelli, A., McDermott, M., Meigs, J., Mozaffarian, D., Nichol, G., O\u2018Donnell, C., Roger, V., Rosamond, W., Sacco, R., Sorlie, P., Stafford, R., Steinberger, J., Thom, T., Wasserthiel-Smoller, S., Wong, N., Wylie-Rosett, J., and Hong, Y. (2009) Heart disease and stroke statistics\u20142009 update: A report from the American heart association statistics committee and stroke statistics subcommittee Circulation\n                  119, e21\u2013181.","journal-title":"Circulation"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1161\/CIRCULATIONAHA.105.537878","volume":"111","author":"P. Libby","year":"2005","unstructured":"Libby, P., and Theroux, P. (2005) Pathophysiology of coronary artery disease Circulation\n                  111, 3481\u20138.","journal-title":"Circulation"},{"key":"9_CR4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1160\/TH05-08-0561","volume":"95","author":"J. Leblond","year":"2006","unstructured":"Leblond, J., Laprise, M. H., Gaudreau, S., Grondin, F., Kisiel, W., and Dubois, C. M. (2006) The serpin proteinase inhibitor 8: An endogenous furin inhibitor released from human platelets Thromb Haemost\n                  95, 243\u201352.","journal-title":"Thromb Haemost"},{"key":"9_CR5","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1161\/hy0202.103000","volume":"39","author":"P. Stawowy","year":"2002","unstructured":"Stawowy, P., Blaschke, F., Kilimnik, A., Goetze, S., Kallisch, H., Chretien, M., Marcinkiewicz, M., Fleck, E., and Graf, K. (2002) Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase\/p70(s6)-kinase activation in vascular smooth muscle cells Hypertension\n                  39, 399\u2013404.","journal-title":"Hypertension"},{"key":"9_CR6","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1161\/CIRCULATIONAHA.104.502617","volume":"111","author":"P. Stawowy","year":"2005","unstructured":"Stawowy, P., Meyborg, H., Stibenz, D., Borges Pereira Stawowy, N., Roser, M., Thanabalasingam, U., Veinot, J. P., Chretien, M., Seidah, N. G., Fleck, E., and Graf, K. (2005) Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis Circulation\n                  111, 2820\u20137.","journal-title":"Circulation"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"6922","DOI":"10.1158\/0008-5472.CAN-07-5408","volume":"68","author":"A. Varshavsky","year":"2008","unstructured":"Varshavsky, A., Kessler, O., Abramovitch, S., Kigel, B., Zaffryar, S., Akiri, G., and Neufeld, G. (2008) Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases Cancer Res\n                  68, 6922\u201331.","journal-title":"Cancer Res"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00428-004-1198-7","volume":"446","author":"P. Stawowy","year":"2005","unstructured":"Stawowy, P., Kallisch, H., Borges Pereira Stawowy, N., Stibenz, D., Veinot, J. P., Grafe, M., Seidah, N. G., Chretien, M., Fleck, E., and Graf, K. (2005) Immunohistochemical localization of subtilisin\/kexin-like proprotein convertases in human atherosclerosis Virchows Arch\n                  446, 351\u20139.","journal-title":"Virchows Arch"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1517\/14728222.12.10.1289","volume":"12","author":"M. Chretien","year":"2008","unstructured":"Chretien, M., Seidah, N. G., Basak, A., and Mbikay, M. (2008) Proprotein convertases as therapeutic targets Expert Opin Ther Targets\n                  12, 1289\u2013300.","journal-title":"Expert Opin Ther Targets"},{"key":"9_CR10","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1161\/ATVBAHA.107.159327","volume":"28","author":"A. C. Doran","year":"2008","unstructured":"Doran, A. C., Meller, N., and McNamara, C. A. (2008) Role of smooth muscle cells in the initiation and early progression of atherosclerosis Arterioscler Thromb Vasc Biol\n                  28, 812\u201319.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/nm1102-1249","volume":"8","author":"V. J. Dzau","year":"2002","unstructured":"Dzau, V. J., Braun-Dullaeus, R. C., and Sedding, D. G. (2002) Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies Nat Med\n                  8, 1249\u201356.","journal-title":"Nat Med"},{"key":"9_CR12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00418-003-0506-7","volume":"119","author":"P. Stawowy","year":"2003","unstructured":"Stawowy, P., Graf, K., Goetze, S., Roser, M., Chretien, M., Seidah, N. G., Fleck, E., and Marcinkiewicz, M. (2003) Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo Histochem Cell Biol\n                  119, 239\u201345.","journal-title":"Histochem Cell Biol"},{"key":"9_CR13","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/01.CIR.0000112583.50762.DE","volume":"109","author":"P. Stawowy","year":"2004","unstructured":"Stawowy, P., Kallisch, H., Veinot, J. P., Kilimnik, A., Prichett, W., Goetze, S., Seidah, N. G., Chretien, M., Fleck, E., and Graf, K. (2004) Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling Circulation\n                  109, 770\u20136.","journal-title":"Circulation"},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00109-005-0723-8","volume":"83","author":"P. Stawowy","year":"2005","unstructured":"Stawowy, P., and Fleck, E. (2005) Proprotein convertases furin and PC5: Targeting atherosclerosis and restenosis at multiple levels J Mol Med\n                  83, 865\u201375.","journal-title":"J Mol Med"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1160\/TH09-07-0478","volume":"103","author":"K. Kappert","year":"2010","unstructured":"Kappert, K., Furundzija, V., Fritzsche, J., Margeta, C., Kruger, J., Meyborg, H., Fleck, E., and Stawowy, P. (2010) Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells Thromb Haemost\n                  103, 556\u201363.","journal-title":"Thromb Haemost"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.biocel.2009.01.004","volume":"41","author":"K. Kappert","year":"2009","unstructured":"Kappert, K., Meyborg, H., Baumann, B., Furundzija, V., Kaufmann, J., Graf, K., Stibenz, D., Fleck, E., and Stawowy, P. (2009) Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion Int J Biochem Cell Biol\n                  41, 1511\u201317.","journal-title":"Int J Biochem Cell Biol"},{"key":"9_CR17","first-page":"208","volume":"49","author":"A. W. Clowes","year":"1983","unstructured":"Clowes, A. W., Reidy, M. A., and Clowes, M. M. (1983) Mechanisms of stenosis after arterial injury Lab Invest\n                  49, 208\u201315.","journal-title":"Lab Invest"},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-59745-571-8_1","volume":"139","author":"D. A. Tulis","year":"2007","unstructured":"Tulis, D. A. (2007) Rat carotid artery balloon injury model Methods Mol Med\n                  139, 1\u201330.","journal-title":"Methods Mol Med"},{"key":"9_CR19","first-page":"319","volume-title":"Laser Capture Microdissection: Methods and Protocols","author":"I. M. Graeme","year":"2005","unstructured":"Graeme, I. M., and Curran, S. (2005) Laser Capture Microdissection: Methods and Protocols. Clifton, NJ: Humana Press. 319\u00a0pp."},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00109-006-0097-6","volume":"84","author":"J. H. Schefe","year":"2006","unstructured":"Schefe, J. H., Lehmann, K. E., Buschmann, I. R., Unger, T., and Funke-Kaiser, H. (2006) Quantitative real-time RT-PCR data analysis: Current concepts and the novel \u201cgene expression\u2019s CT difference\u201d formula J Mol Med\n                  84, 901\u201310.","journal-title":"J Mol Med"},{"key":"9_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1096\/fj.06-6219com","volume":"21","author":"K. Kappert","year":"2007","unstructured":"Kappert, K., Paulsson, J., Sparwel, J., Leppanen, O., Hellberg, C., Ostman, A., and Micke, P. (2007) Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation FASEB J\n                  21, 523\u201334.","journal-title":"FASEB J"}],"container-title":["Methods in Molecular Biology","Proprotein Convertases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-61779-204-5_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T09:40:28Z","timestamp":1676713228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-61779-204-5_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"ISBN":["9781617792038","9781617792045"],"references-count":21,"URL":"https:\/\/doi.org\/10.1007\/978-1-61779-204-5_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]},"assertion":[{"value":"13 July 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}