{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:01:53Z","timestamp":1784818913435,"version":"3.55.0"},"publisher-location":"Totowa, NJ","reference-count":75,"publisher":"Humana Press","isbn-type":[{"value":"9781617795350","type":"print"},{"value":"9781617795367","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-1-61779-536-7_2","type":"book-chapter","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T21:39:07Z","timestamp":1330119547000},"page":"13-22","source":"Crossref","is-referenced-by-count":21,"title":["Neuronal Growth-Promoting and Inhibitory Cues in Neuroprotection and Neuroregeneration"],"prefix":"10.1007","author":[{"given":"Stephen D.","family":"Skaper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"2_CR1_2","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1126\/science.274.5290.1123","volume":"274","author":"M Tessier-Lavigne","year":"1996","unstructured":"Tessier-Lavigne M, and Goodman CS (1996) The molecular biology of axonal guidance. Science 274, 1123\u20131133","journal-title":"Science"},{"key":"2_CR2_2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev.cellbio.13.1.425","volume":"13","author":"FS Walsh","year":"1997","unstructured":"Walsh FS, and Doherty P (1997) Neural cell adhesion molecules of the immunoglobulin superfamily: role in axonal growth and guidance. Annu Rev Cell Dev Biol 13, 425\u2013456","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2_CR3_2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1146\/annurev.ne.19.030196.002423","volume":"19","author":"NY Ip","year":"1996","unstructured":"Ip NY, and Yancopoulos GD (1996) The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 19, 491\u2013515","journal-title":"Annu Rev Neurosci"},{"key":"2_CR4_2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/mcne.1998.0714","volume":"12","author":"SD Skaper","year":"1998","unstructured":"Skaper SD, and Walsh FS (1998) Neurotrophic molecules: strategies for designing effective therapeutic molecules in neurodegeneration. Mol Cell Neurosci 12, 179\u2013193","journal-title":"Mol Cell Neurosci"},{"key":"2_CR5_2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/0092-8674(94)90420-0","volume":"78","author":"T Serefini","year":"1994","unstructured":"Serefini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, and Tessier-Lavigne M (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409\u2013424","journal-title":"Cell"},{"key":"2_CR6_2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev.neuro.22.1.351","volume":"22","author":"BK Mueller","year":"1999","unstructured":"Mueller BK (1999) Growth cone guidance: first steps toward a deeper understanding. Annu Rev Neurosci 22, 351\u2013388","journal-title":"Annu Rev Neurosci"},{"key":"2_CR7_2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0959-4388(00)00178-1","volume":"11","author":"AE Fournier","year":"2001","unstructured":"Fournier AE, and Strittmatter SM (2001) Repulsive factors and axon regeneration in the CNS. Curr Opin Neurobiol 11, 89\u201394","journal-title":"Curr Opin Neurobiol"},{"key":"2_CR8_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0962-8924(96)81033-6","volume":"6","author":"AL Kolodkin","year":"1996","unstructured":"Kolodkin AL (1996) Semaphorins: mediators of repulsive growth cone guidance. Trends Cell Biol 6: 15\u201322","journal-title":"Trends Cell Biol"},{"key":"2_CR9_2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1146\/annurev.ne.19.030196.002013","volume":"19","author":"CS Goodman","year":"1996","unstructured":"Goodman CS (1996) Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 19, 341\u2013377","journal-title":"Annu Rev Neurosci"},{"key":"2_CR10_2","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/hmg\/9.6.879","volume":"9","author":"S Kenwrick","year":"2000","unstructured":"Kenwrick S, Watkins A, and De Angelis E (2000) Neural cell recognition molecule L1: relating biological complexity to human disease mutations. Hum Mol Genet 9, 879\u2013886","journal-title":"Hum Mol Genet"},{"key":"2_CR11_2","volume-title":"Degeneration and Regeneration of the Nervous System","author":"RS Cajal","year":"1928","unstructured":"Cajal RS (1928) Degeneration and Regeneration of the Nervous System. Hafner. New York."},{"key":"2_CR12_2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0166-2236(03)00062-6","volume":"26","author":"AW McGee","year":"2003","unstructured":"McGee AW, and Strittmatter SM (2003) The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. Trends Neurosci 26, 193\u2013198","journal-title":"Trends Neurosci"},{"key":"2_CR13_2","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/35000601","volume":"403","author":"MS Chen","year":"2000","unstructured":"Chen MS, Huber AB, Van Der Haar ME, Frank M, Schnell L, Spillmann AA, et al (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434\u2013439","journal-title":"Nature"},{"key":"2_CR14_2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/35000226","volume":"403","author":"T GrandPr\u00e9","year":"2000","unstructured":"GrandPr\u00e9 T, Nakamura F, Vartanian T, and Strittmatter SM (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439\u2013444","journal-title":"Nature"},{"key":"2_CR15_2","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/35000287","volume":"403","author":"R Prinjha","year":"2000","unstructured":"Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, et al (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383\u2013384","journal-title":"Nature"},{"key":"2_CR16_2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","volume":"13","author":"L McKerracher","year":"1994","unstructured":"McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, and Braun PE (1994) Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite outgrowth. Neuron 13, 805\u2013811","journal-title":"Neuron"},{"key":"2_CR17_2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/0896-6273(94)90042-6","volume":"13","author":"G Mukhopadhyay","year":"1994","unstructured":"Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, and Filbin MT (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757\u2013767","journal-title":"Neuron"},{"key":"2_CR18_2","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nature00867","volume":"417","author":"KC Wang","year":"2002","unstructured":"Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, et al (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941\u2013944","journal-title":"Nature"},{"key":"2_CR19_2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1126\/science.3055291","volume":"242","author":"J Dodd","year":"1988","unstructured":"Dodd J, and Jessell JM (1988) Axon guidance and the patterning of neuronal projections in vertebrates. Science 242, 692\u2013699","journal-title":"Science"},{"issue":"suppl. 10","key":"2_CR20_2","first-page":"77","volume":"72","author":"CS Goodman","year":"1993","unstructured":"Goodman CS, and Shatz CJ (1993) Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell\/Neuron 72(suppl. 10), 77\u201398","journal-title":"Cell\/Neuron"},{"key":"2_CR21_2","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0955-0674(95)80102-2","volume":"7","author":"M Takeichi","year":"1995","unstructured":"Takeichi M (1995) Morphogenetic role of classic cadherins. Curr Opin Cell Biol 7, 619\u2013627","journal-title":"Curr Opin Cell Biol"},{"key":"2_CR22_2","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/0896-6273(94)90026-4","volume":"13","author":"K Barami","year":"1994","unstructured":"Barami K, Kirschenbaum B, Lemmon V, and Goldman SA (1994) N-Cadherin and Ng-CAM\/8D9 are involved serially in the migration of newly generated neurons into the adult songbird brain. Neuron 13, 567\u2013582","journal-title":"Neuron"},{"key":"2_CR23_2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/334062a0","volume":"334","author":"M Matsunaga","year":"1988","unstructured":"Matsunaga M, Hatta K, Nagafuchi A, and Takeichi M (1988) Guidance of optic nerve fibers by N-cadherin adhesion molecules. Nature 334, 62\u201364","journal-title":"Nature"},{"key":"2_CR24_2","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1126\/science.276.5317.1428","volume":"276","author":"A Inoue","year":"1997","unstructured":"Inoue A, and Sanes JR (1997) Lamina-specific connectivity in the brain: regulation by N-cadherin, neurotrophins, and glycoproteins. Science 276, 1428\u20131431","journal-title":"Science"},{"key":"2_CR25_2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0896-6273(00)00100-8","volume":"28","author":"O Bozdagi","year":"2000","unstructured":"Bozdagi O, Shan W, Tanaka H, Benson DL, and Huntley GW (2000) Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Neuron 28, 245\u2013259","journal-title":"Neuron"},{"key":"2_CR26_2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0896-6273(00)80264-0","volume":"18","author":"JL Saffell","year":"1997","unstructured":"Saffell JL, Williams EJ, Mason IJ, Walsh FS, and Doherty P (1997) Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18, 231\u2013242","journal-title":"Neuron"},{"key":"2_CR27_2","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0896-6273(94)90027-2","volume":"13","author":"E-J Williams","year":"1994","unstructured":"Williams E-J, Furness J, Walsh FS, and Doherty P (1994) Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 13, 583\u2013594","journal-title":"Neuron"},{"key":"2_CR28_2","doi-asserted-by":"publisher","first-page":"43879","DOI":"10.1074\/jbc.M105876200","volume":"276","author":"E-J Williams","year":"2001","unstructured":"Williams E-J, Williams G, Howell FV, Skaper SD, Walsh FS, and Doherty P (2001) Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth. J Biol Chem 276, 43879\u201343886","journal-title":"J Biol Chem"},{"key":"2_CR29_2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0896-6273(95)90240-6","volume":"14","author":"P Doherty","year":"1995","unstructured":"Doherty P, Williams E, and Walsh FS (1995) A soluble form of the L1 glycoprotein stimulated neurite outgrowth. Neuron 14, 57\u201366","journal-title":"Neuron"},{"key":"2_CR30_2","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1046\/j.1471-4159.2001.00140.x","volume":"76","author":"MA Utton","year":"2001","unstructured":"Utton MA, Eickholt B, Howell FV, Wallis J, and Doherty P (2001) Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells. J Neurochem 76, 1421\u20131430","journal-title":"J Neurochem"},{"key":"2_CR31_2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0959-440X(99)80038-4","volume":"9","author":"AW Koch","year":"1999","unstructured":"Koch AW, Bozic D, Pertz O, and Engel J (1999) Homophilic adhesion by cadherins. Curr Opin Struct Biol 9, 275\u2013281","journal-title":"Curr Opin Struct Biol"},{"key":"2_CR32_2","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1074\/jbc.275.6.4007","volume":"275","author":"E Williams","year":"2000","unstructured":"Williams E, Williams G, Gour BJ, Blaschuk OW, and Doherty P (2000) A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif. J Biol Chem 275, 4007\u20134012","journal-title":"J Biol Chem"},{"key":"2_CR33_2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1006\/mcne.2000.0847","volume":"15","author":"EJ Williams","year":"2000","unstructured":"Williams EJ, Williams G, Gour B, Blaschuk O, and Doherty P (2000) INP, a novel N-cadherin antagonist targeted to the amino acids that flank the HAV motif. Mol Cell Neurosci 15, 456\u2013464","journal-title":"Mol Cell Neurosci"},{"key":"2_CR34_2","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1074\/jbc.M109185200","volume":"277","author":"G Williams","year":"2002","unstructured":"Williams G, Williams E-J, and Doherty P (2002) Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists. J Biol Chem 277, 4361\u20134367","journal-title":"J Biol Chem"},{"key":"2_CR35_2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mcn.2003.12.015","volume":"26","author":"SD Skaper","year":"2004","unstructured":"Skaper SD, Facci, L, Williams G, Williams EJ, Walsh FS, and Doherty P (2004) A dimeric version of the short N-cadherin binding motif HAVDI promotes neuronal cell survival by activating an N-cadherin\/fibroblast growth factor receptor signalling cascade. Mol Cell Neurosci 26, 17\u201323","journal-title":"Mol Cell Neurosci"},{"key":"2_CR36_2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/(SICI)1097-4695(19990215)38:3<428::AID-NEU10>3.0.CO;2-6","volume":"38","author":"S Chen","year":"1999","unstructured":"Chen S, Mantei N, Dong L, and Schachner M (1999) Prevention of neuronal cell death by neural cell adhesion molecules L1 and CHL1. J Neurobiol 38, 428\u2013439","journal-title":"J Neurobiol"},{"key":"2_CR37_2","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1046\/j.1471-4159.2003.01538.x","volume":"84","author":"DK Ditlevsen","year":"2003","unstructured":"Ditlevsen DK, K\u00f8hler LB, Pedersen MV, Risell M, Kolkova K, Meyer M, et al (2003) The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule\u2013mediated neuronal differentiation and survival. J Neurochem 84, 546\u2013556","journal-title":"J Neurochem"},{"key":"2_CR38_2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0896-6273(02)00765-1","volume":"35","author":"Y Goda","year":"2002","unstructured":"Goda Y (2002) Cadherins communicate structural plasticity of presynaptic and postsynaptic terminals. Neuron 35, 1\u20133","journal-title":"Neuron"},{"key":"2_CR39_2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0896-6273(02)00748-1","volume":"35","author":"H Togashi","year":"2002","unstructured":"Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, and Takeichi M (2002) Cadherin regulates dendritic spine morphogenesis. Neuron 35, 77\u201389","journal-title":"Neuron"},{"key":"2_CR40_2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0955-0674(97)80115-9","volume":"9","author":"M Schachner","year":"1997","unstructured":"Schachner M (1997) Neural recognition molecules and synaptic plasticity. Curr Opin Cell Biol 9, 627\u2013634","journal-title":"Curr Opin Cell Biol"},{"key":"2_CR41_2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0962-8924(00)01838-9","volume":"10","author":"DL Benson","year":"2000","unstructured":"Benson DL, Schnapp LM, Shapiro L, and Huntley GW (2000) Making memories stick: cell adhesion molecules in synaptic plasticity. Trends Cell Biol 10, 473\u2013482","journal-title":"Trends Cell Biol"},{"key":"2_CR42_2","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/372777a0","volume":"372","author":"A L\u00fcthi","year":"1994","unstructured":"L\u00fcthi A, Laurent JP, Figurov A, Muller D, and Schachner M (1994) Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372, 777\u2013779","journal-title":"Nature"},{"key":"2_CR43_2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-8993(95)00147-I","volume":"677","author":"LCB R\u00f8nn","year":"1995","unstructured":"R\u00f8nn LCB, Bock E, Linnemann D, and Jahnsen H (1995) NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1. Brain Res 677, 145\u2013151","journal-title":"Brain Res"},{"key":"2_CR44_2","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1111\/j.1471-4159.1992.tb08477.x","volume":"59","author":"E Doyle","year":"1992","unstructured":"Doyle E, Nolan PM, Bell R, and Regan CM (1992) Intraventricular infusions of anti-neural cell adhesion molecules in discrete posttraining period impair consolidation of a passive avoidance response in the rat. J Neurochem 59, 1570\u20131573","journal-title":"J Neurochem"},{"key":"2_CR45_2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/367455a0","volume":"367","author":"H Cremer","year":"1994","unstructured":"Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, et al (1994) Inactivation of the NCAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367, 455\u2013459","journal-title":"Nature"},{"key":"2_CR46_2","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/13697","volume":"17","author":"LCB R\u00f8nn","year":"1999","unstructured":"R\u00f8nn LCB, Olsen M, Ostergaard S, Kiselyov V, Berezin V, Mortensen MT, et al (1999) Identification of a neuritogenic ligand of the neural cell adhesion molecule using a combinatorial library of synthetic peptides. Nat Biotech 17, 1000\u20131005","journal-title":"Nat Biotech"},{"key":"2_CR47_2","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1083\/jcb.125.2.427","volume":"125","author":"JL Saffell","year":"1994","unstructured":"Saffell JL, Walsh FS, and Doherty P (1994) Expression of NCAM containing VASE in neurons can account for a developmental loss in their neuritic outgrowth response to NCAM in a cellular substratum. J Cell Biol 125, 427\u2013436","journal-title":"J Cell Biol"},{"key":"2_CR48_2","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0969-2126(03)00096-0","volume":"11","author":"VV Kiselyov","year":"2003","unstructured":"Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, et al (2003) Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure 11, 691\u2013701","journal-title":"Structure"},{"key":"2_CR49_2","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1523\/JNEUROSCI.0436-04.2004","volume":"24","author":"K Cambon","year":"2004","unstructured":"Cambon K, Hansen SM, Venero C, Herrero AI, Skibo G, Berezin V, et al (2004) A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. J Neurosci 24, 4197\u20134204","journal-title":"J Neurosci"},{"key":"2_CR50_2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0361-9230(99)00072-6","volume":"49","author":"JW Fawcett","year":"1999","unstructured":"Fawcett JW, and Asher RA (1999) The glial scar and central nervous system repair. Brain Res Bull 49, 377\u2013391","journal-title":"Brain Res Bull"},{"key":"2_CR51_2","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1523\/JNEUROSCI.05-09-02415.1985","volume":"5","author":"ME Schwab","year":"1985","unstructured":"Schwab ME, and Thoenen H (1985) Dissociated neurons regenerate into sciatic, but not optic nerve explants irrespective of neurotrophic factors. J Neurosci 5, 2415\u20132423","journal-title":"J Neurosci"},{"key":"2_CR52_2","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1523\/JNEUROSCI.08-07-02381.1988","volume":"8","author":"ME Schwab","year":"1988","unstructured":"Schwab ME, and Caroni P (1988) Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J Neurosci 8, 2381\u20132393","journal-title":"J Neurosci"},{"key":"2_CR53_2","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1523\/JNEUROSCI.19-20-08979.1999","volume":"19","author":"BP Nieder\u00f6st","year":"1999","unstructured":"Nieder\u00f6st BP, Zimmermann DR, Schwab ME, and Bandtlow CE (1999) Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulphate proteoglycans. J Neurosci 19, 8979\u20138989","journal-title":"J Neurosci"},{"key":"2_CR54_2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/35053072","volume":"409","author":"AE Fournier","year":"2001","unstructured":"Fournier AE, GrandPre T, and Strittmatter SM (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341\u2013346","journal-title":"Nature"},{"key":"2_CR55_2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0896-6273(02)00770-5","volume":"35","author":"M Domeniconi","year":"2002","unstructured":"Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, et al (2002) Myelin-associated glycoprotein interacts with the nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283\u2013290","journal-title":"Neuron"},{"key":"2_CR56_2","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1073031","volume":"297","author":"BP Liu","year":"2002","unstructured":"Liu BP, Fournier A, GrandPr\u00e9 T, and Strittmatter SM (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297, 1190\u20131193","journal-title":"Science"},{"key":"2_CR57_2","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nature00867","volume":"417","author":"KC Wang","year":"2002","unstructured":"Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, et al (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941\u2013944","journal-title":"Nature"},{"key":"2_CR58_2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/nature01176","volume":"420","author":"KC Wang","year":"2002","unstructured":"Wang KC, Kim JA, Sivasankaran R, Segal R, and He Z (2002) p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG, and OMgp. Nature 420, 74\u201378","journal-title":"Nature"},{"key":"2_CR59_2","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/nn975","volume":"5","author":"ST Wong","year":"2002","unstructured":"Wong ST, Henley JR, Kanning KC, Huang KH, Bothwell M, and Poo MM (2002) A p75 (NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci 5, 1302\u20131308","journal-title":"Nat Neurosci"},{"key":"2_CR60_2","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nrd1228","volume":"2","author":"DHS Lee","year":"2003","unstructured":"Lee DHS, Strittmatter SM, and Sah DWY (2003) Targeting the Nogo receptor to treat central nervous system injuries. Nat Rev Drug Discovery 2, 872\u2013879","journal-title":"Nat Rev Drug Discovery"},{"key":"2_CR61_2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/378498a0","volume":"378","author":"BS Bregman","year":"1995","unstructured":"Bregman BS, Kunkel-Bagden E, Schnell L, Dai HN, Gao D, and Schwab ME (1995) Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498\u2013501","journal-title":"Nature"},{"key":"2_CR62_2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/373","volume":"1","author":"M Thallmair","year":"1998","unstructured":"Thallmair M, Metz GA, Z\u2019Graggen WJ, Raineteau O, Kartje GL, and Schwab ME (1998) Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nat Neurosci 1, 124\u2013131","journal-title":"Nat Neurosci"},{"key":"2_CR63_2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/417547a","volume":"417","author":"T GrandPre","year":"2002","unstructured":"GrandPre T, Li S, and Strittmatter SM (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417, 547\u2013551","journal-title":"Nature"},{"key":"2_CR64_2","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1523\/JNEUROSCI.23-10-04219.2003","volume":"23","author":"S Li","year":"2003","unstructured":"Li S, and Strittmatter SM (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci 23, 4219\u20134227","journal-title":"J Neurosci"},{"key":"2_CR65_2","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.1523\/JNEUROSCI.1643-04.2004","volume":"24","author":"J-K Lee","year":"2004","unstructured":"Lee J-K, Kim J-E, Sivula M, and Strittmatter SM (2004) Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci 24, 6209\u20136217","journal-title":"J Neurosci"},{"key":"2_CR66_2","doi-asserted-by":"publisher","first-page":"43780","DOI":"10.1074\/jbc.M401803200","volume":"279","author":"W Li","year":"2004","unstructured":"Li W, Walus L, Rabacchi SA, Jirik A, Chang E, Schauer J, (2004) A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin. J Biol Chem 279, 43780\u201343788","journal-title":"J Biol Chem"},{"key":"2_CR67_2","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.nbd.2008.09.012","volume":"32","author":"P Yu","year":"2008","unstructured":"Yu P, Huang L, Zou J, Yu Z, Wang Y, Wang Z, et al (2008) Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats. Neurobiol Dis 32, 535\u2013542","journal-title":"Neurobiol Dis"},{"key":"2_CR68_2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/35044547","volume":"1","author":"L Luo","year":"2000","unstructured":"Luo L (2000) Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 1, 173\u2013180","journal-title":"Nat Rev Neurosci"},{"key":"2_CR69_2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0896-6273(00)81175-7","volume":"26","author":"H Bito","year":"2000","unstructured":"Bito H, Furuyashiki T, Ishihara H, Shibasaki Y, Ohashi K, Mizuno K (2000) A critical role for Rho-associated kinase, p160ROCK, in determining axonal outgrowth in mammalian CNS neurons. Neuron 26, 431\u2013441","journal-title":"Neuron"},{"key":"2_CR70_2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1083\/jcb.200202010","volume":"157","author":"T Yamashita","year":"2002","unstructured":"Yamashita T, Higuchi H, and Tohyama M (2002) The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol 157, 565\u2013570","journal-title":"J Cell Biol"},{"key":"2_CR71_2","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003","volume":"23","author":"AE Fournier","year":"2003","unstructured":"Fournier AE, Takizawa BT, and Strittmatter SM (2003) Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci 23, 1416\u20131423","journal-title":"J Neurosci"},{"key":"2_CR72_2","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1523\/JNEUROSCI.22-23-10368.2002","volume":"22","author":"B Nieder\u00f6st","year":"2002","unstructured":"Nieder\u00f6st B, Oertle T, Fritsche J, McKinney RA, and Bandtlow CE (2002) Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci 22, 10368\u201310376","journal-title":"J Neurosci"},{"key":"2_CR73_2","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1523\/JNEUROSCI.22-15-06570.2002","volume":"22","author":"P Dergham","year":"2002","unstructured":"Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell WD, and McKerracher L (2002) Rho signalling pathway targeted to promote spinal cord repair. J Neurosci 22, 6570\u20136577","journal-title":"J Neurosci"},{"key":"2_CR74_2","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.2174\/138161207781368657","volume":"13","author":"T Kubo","year":"2007","unstructured":"Kubo T, Hata, K, Yamaguchi A, and Yamashita T (2007) Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr Pharm Des 13, 2493\u20132499","journal-title":"Curr Pharm Des"},{"key":"2_CR75_2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mcn.2003.12.015","volume":"26","author":"SD Skaper","year":"2004","unstructured":"Skaper, S.D., Facci, L., Gilliams, G., Williams, E.-J., Walsh, F.S. and P. Doherty (2004) A dimeric version of the short N-cadherin binding motif HAVDI promotes neuronal cell survival by activating an N-cadherin\/fibroblast growth factor receptor signalling cascade. Mol and Cell Neurosc 26, 17\u201323","journal-title":"Mol and Cell Neurosc"}],"container-title":["Methods in Molecular Biology","Neurotrophic Factors"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-61779-536-7_2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T21:42:56Z","timestamp":1619905376000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-61779-536-7_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9781617795350","9781617795367"],"references-count":75,"URL":"https:\/\/doi.org\/10.1007\/978-1-61779-536-7_2","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}