{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:56:09Z","timestamp":1779242169343,"version":"3.51.4"},"publisher-location":"Totowa, NJ","reference-count":20,"publisher":"Humana Press","isbn-type":[{"value":"9781627032896","type":"print"},{"value":"9781627032902","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-62703-290-2_8","type":"book-chapter","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T17:29:01Z","timestamp":1360344541000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of CD4+ and CD8+ T Cell Responses Using MHC Class I and II Tetramers"],"prefix":"10.1007","author":[{"given":"Sema","family":"Kurtulus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hildeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"8_CR00081","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/369648a0","volume":"369","author":"LL Lau","year":"1994","unstructured":"Lau LL, Jamieson BD, Somasundaram T, Ahmed R (1994) Cytotoxic T-cell memory without antigen. Nature 369:648\u2013652","journal-title":"Nature"},{"key":"8_CR00082","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4049\/jimmunol.154.2.620","volume":"154","author":"ES Razvi","year":"1995","unstructured":"Razvi ES, Welsh RM, McFarland HI (1995) In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice. J Immunol 154:620\u2013632","journal-title":"J Immunol"},{"key":"8_CR00083","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1084\/jem.179.6.1933","volume":"179","author":"LK Selin","year":"1994","unstructured":"Selin LK, Nahill SR, Welsh RM (1994) Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J Exp Med 179:1933\u20131943","journal-title":"J Exp Med"},{"key":"8_CR00084","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.4049\/jimmunol.154.11.6013","volume":"154","author":"RA Tripp","year":"1995","unstructured":"Tripp RA, Hou S, McMickle A, Houston J, Doherty PC (1995) Recruitment and proliferation of CD8+ T cells in respiratory virus infections. J Immunol 154:6013\u20136021","journal-title":"J Immunol"},{"key":"8_CR00085","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S1074-7613(00)80469-0","volume":"8","author":"EA Butz","year":"1998","unstructured":"Butz EA, Bevan MJ (1998) Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8:167\u2013175","journal-title":"Immunity"},{"key":"8_CR00086","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/ni1227","volume":"6","author":"AL Marzo","year":"2005","unstructured":"Marzo AL, Klonowski KD, Le Bon A, Borrow P, Tough DF, Lefrancois L (2005) Initial T cell frequency dictates memory CD8+ T cell lineage commitment. Nat Immunol 6:793\u2013799","journal-title":"Nat Immunol"},{"key":"8_CR00087","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.274.5284.94","volume":"274","author":"JD Altman","year":"1996","unstructured":"Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94\u201396","journal-title":"Science"},{"key":"8_CR00088","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","volume":"8","author":"K Murali-Krishna","year":"1998","unstructured":"Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, Miller JD, Slansky J, Ahmed R (1998) Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8: 177\u2013187","journal-title":"Immunity"},{"key":"8_CR00089","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.170.1.477","volume":"170","author":"MJ Fuller","year":"2003","unstructured":"Fuller MJ, Zajac AJ (2003) Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol 170:477\u2013486","journal-title":"J Immunol"},{"key":"8_CR000810","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S1074-7613(00)80572-5","volume":"8","author":"F Crawford","year":"1998","unstructured":"Crawford F, Kozono H, White J, Marrack P, Kappler J (1998) Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8: 675\u2013682","journal-title":"Immunity"},{"key":"8_CR000811","doi-asserted-by":"publisher","first-page":"9781","DOI":"10.1073\/pnas.96.17.9781","volume":"96","author":"W Rees","year":"1999","unstructured":"Rees W, Bender J, Teague TK, Kedl RM, Crawford F, Marrack P, Kappler J (1999) An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A 96:9781\u20139786","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR000812","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1002\/eji.200635897","volume":"36","author":"S Wojciechowski","year":"2006","unstructured":"Wojciechowski S, Jordan MB, Zhu Y, White J, Zajac AJ, Hildeman DA (2006) Bim mediates apoptosis of CD127 (lo) effector T cells and limits T cell memory. Eur J Immunol 36: 1694\u20131706","journal-title":"Eur J Immunol"},{"key":"8_CR000813","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1126\/science.1058867","volume":"291","author":"D Masopust","year":"2001","unstructured":"Masopust D, Vezys V, Marzo AL, Lefrancois L (2001) Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413\u20132417","journal-title":"Science"},{"key":"8_CR000814","doi-asserted-by":"publisher","first-page":"8604","DOI":"10.1128\/JVI.02477-08","volume":"83","author":"AA Lin","year":"2009","unstructured":"Lin AA, Tripathi PK, Sholl A, Jordan MB, Hildeman DA (2009) Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production. J Virol 83:8604\u20138615","journal-title":"J Virol"},{"key":"8_CR000815","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1128\/jvi.69.4.2297-2305.1995","volume":"69","author":"JE Gairin","year":"1995","unstructured":"Gairin JE, Mazarguil H, Hudrisier D, Oldstone MB (1995) Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J Virol 69:2297\u20132305","journal-title":"J Virol"},{"key":"8_CR000816","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1002\/eji.1830251230","volume":"25","author":"A Oxenius","year":"1995","unstructured":"Oxenius A, Bachmann MF, Ashton-Rickardt PG, Tonegawa S, Zinkernagel RM, Hengartner H (1995) Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system. Eur J Immunol 25:3402\u20133411","journal-title":"Eur J Immunol"},{"key":"8_CR000817","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4049\/jimmunol.169.1.359","volume":"169","author":"MC Gold","year":"2002","unstructured":"Gold MC, Munks MW, Wagner M, Koszinowski UH, Hill AB, Fling SP (2002) The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo. J Immunol 169:359\u2013365","journal-title":"J Immunol"},{"key":"8_CR000818","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.4049\/jimmunol.180.10.6472","volume":"180","author":"R Arens","year":"2008","unstructured":"Arens R, Wang P, Sidney J, Loewendorf A, Sette A, Schoenberger SP, Peters B, Benedict CA (2008) Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response. J Immunol 180:6472\u20136476","journal-title":"J Immunol"},{"key":"8_CR000819","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1073\/pnas.0400525101","volume":"101","author":"K Tabeta","year":"2004","unstructured":"Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J, Alexopoulou L, Flavell RA, Beutler B (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 101:3516\u20133521","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR000820","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1084\/jem.182.4.1045","volume":"182","author":"JS Orange","year":"1995","unstructured":"Orange JS, Wang B, Terhorst C, Biron CA (1995) Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J Exp Med 182:1045\u20131056","journal-title":"J Exp Med"}],"container-title":["Methods in Molecular Biology","Immune Homeostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-290-2_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T13:45:36Z","timestamp":1676295936000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-290-2_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781627032896","9781627032902"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-290-2_8","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"4 January 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}