{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:59:06Z","timestamp":1779188346808,"version":"3.51.4"},"publisher-location":"Totowa, NJ","reference-count":32,"publisher":"Humana Press","isbn-type":[{"value":"9781627033077","type":"print"},{"value":"9781627033084","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-62703-308-4_14","type":"book-chapter","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T07:15:29Z","timestamp":1362208529000},"page":"213-225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ARA290 in a Rat Model of Inflammatory Pain"],"prefix":"10.1007","author":[{"given":"Andrew","family":"Dilley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"14_CR00141","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87\u2013107","journal-title":"Pain"},{"key":"14_CR00142","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","volume":"50","author":"SH Kim","year":"1992","unstructured":"Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355\u2013363","journal-title":"Pain"},{"key":"14_CR00143","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","volume":"87","author":"I Decosterd","year":"2000","unstructured":"Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149\u2013158","journal-title":"Pain"},{"key":"14_CR00144","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S1090-3801(98)90009-X","volume":"2","author":"Y Chen","year":"1998","unstructured":"Chen Y, Devor M (1998) Ectopic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis. Eur J Pain 2:165\u2013178","journal-title":"Eur J Pain"},{"key":"14_CR00145","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1152\/jn.1995.74.3.1020","volume":"74","author":"M Michaelis","year":"1995","unstructured":"Michaelis M, Blenk KH, Janig W, Vogel C (1995) Development of spontaneous activity and mechanosensitivity in axotomized afferent nerve fibers during the first hours after nerve transection in rats. J Neurophysiol 74:1020\u20131027","journal-title":"J Neurophysiol."},{"key":"14_CR00146","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0014-4886(81)90271-5","volume":"73","author":"JW Scadding","year":"1981","unstructured":"Scadding JW (1981) Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons. Exp Neurol 73:345\u2013364","journal-title":"Exp Neurol"},{"key":"14_CR00147","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/0304-3959(95)00175-1","volume":"64","author":"M Tal","year":"1996","unstructured":"Tal M, Eliav E (1996) Abnormal discharge originates at the site of nerve injury in experimental constriction neuropathy (CCI) in the rat. Pain 64:511\u2013518","journal-title":"Pain"},{"key":"14_CR00148","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S1474-4422(03)00557-X","volume":"2","author":"W Janig","year":"2003","unstructured":"Janig W, Baron R (2003) Complex regional pain syndrome: mystery explained? Lancet Neurol 2:687\u2013697","journal-title":"Lancet Neurol."},{"key":"14_CR00149","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mus.22221","volume":"44","author":"A Dilley","year":"2011","unstructured":"Dilley A (2011) MRI signal hyper-intensity of neural tissues in diffuse chronic pain syndromes\u2014a pilot study. Muscle Nerve 44:981\u2013984","journal-title":"Muscle Nerve"},{"key":"14_CR001410","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1152\/jn.00175.2003","volume":"90","author":"GM Bove","year":"2003","unstructured":"Bove GM, Ransil BJ, Lin HC, Leem JG (2003) Inflammation induces ectopic mechanical \u00adsensitivity in axons of nociceptors innervating deep tissues. J Neurophysiol 90:1949\u20131955","journal-title":"J Neurophysiol."},{"key":"14_CR001411","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1046\/j.1529-8027.2001.006001111.x","volume":"6","author":"LS Gazda","year":"2001","unstructured":"Gazda LS, Milligan ED, Hansen MK, Twining CM, Poulos NM, Chacur M, O\u2019Connor KA, Armstrong C, Maier SF, Watkins LR, Myers RR (2001) Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production. J Peripher Nerv Syst 6:111\u2013129","journal-title":"J Peripher Nerv Syst"},{"key":"14_CR001412","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.pain.2005.08.018","volume":"117","author":"A Dilley","year":"2005","unstructured":"Dilley A, Lynn B, Pang SJ (2005) Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk. Pain 117:462\u2013472","journal-title":"Pain"},{"key":"14_CR001413","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0304-3959(99)00102-5","volume":"83","author":"E Eliav","year":"1999","unstructured":"Eliav E, Herzberg U, Ruda MA, Bennett GJ (1999) Neuropathic pain from an experimental neuritis of the rat sciatic nerve. Pain 83:169\u2013182","journal-title":"Pain"},{"key":"14_CR001414","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneuroim.2009.06.005","volume":"213","author":"GM Bove","year":"2009","unstructured":"Bove GM, Weissner W, Barbe MF (2009) Long lasting recruitment of immune cells and altered epi-perineurial thickness in focal nerve inflammation induced by complete Freund\u2019s adjuvant. J Neuroimmunol 213:26\u201330","journal-title":"J Neuroimmunol"},{"key":"14_CR001415","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S1090-3801(97)90052-5","volume":"1","author":"ST Meller","year":"1997","unstructured":"Meller ST, Gebhart GF (1997) Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat. Eur J Pain 1:43\u201352","journal-title":"Eur J Pain"},{"key":"14_CR001416","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0304-3959(01)00354-2","volume":"94","author":"M Chacur","year":"2001","unstructured":"Chacur M, Milligan ED, Gazda LS, Armstrong C, Wang HC, Tracey KJ, Maier SF, Watkins LR (2001) A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain 94:231\u2013244","journal-title":"Pain"},{"key":"14_CR001417","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0304-3940(01)02143-7","volume":"311","author":"E Eliav","year":"2001","unstructured":"Eliav E, Benoliel R, Tal M (2001) Inflammation with no axonal damage of the rat saphenous nerve trunk induces ectopic discharge and mechanosensitivity in myelinated axons. Neurosci Lett 311:49\u201352","journal-title":"Neurosci Lett."},{"key":"14_CR001418","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jneumeth.2010.02.010","volume":"188","author":"GM Bove","year":"2010","unstructured":"Bove GM, Dilley A (2010) The conundrum of sensitization when recording from nociceptors. J Neurosci Methods 188:213\u2013218","journal-title":"J Neurosci Methods"},{"key":"14_CR001419","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1152\/jn.00183.2011","volume":"106","author":"N Richards","year":"2011","unstructured":"Richards N, Batty T, Dilley A (2011) CCL2 has similar excitatory effects to TNF-alpha in a subgroup of inflamed C-fiber axons. J Neurophysiol 106:2838\u20132848","journal-title":"J Neurophysiol"},{"key":"14_CR001420","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","volume":"52","author":"JN Campbell","year":"2006","unstructured":"Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52:77\u201392","journal-title":"Neuron"},{"key":"14_CR001421","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0304-3959(92)90259-E","volume":"51","author":"RH Gracely","year":"1992","unstructured":"Gracely RH, Lynch SA, Bennett GJ (1992) Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51:175\u2013194","journal-title":"Pain"},{"key":"14_CR001422","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/jn.1991.66.1.190","volume":"66","author":"RH LaMotte","year":"1991","unstructured":"LaMotte RH, Shain CN, Simone DA, Tsai EP (1991) Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66:190\u2013211","journal-title":"J Neurophysiol"},{"key":"14_CR001423","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbi.2009.01.012","volume":"23","author":"E Eliav","year":"2009","unstructured":"Eliav E, Benoliel R, Herzberg U, Kalladka M, Tal M (2009) The role of IL-6 and IL-1beta in painful perineural inflammatory neuritis. Brain Behav Immun 23:474\u2013484","journal-title":"Brain Behav Immun"},{"key":"14_CR001424","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.pain.2004.04.008","volume":"110","author":"CM Twining","year":"2004","unstructured":"Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF, Watkins LR (2004) Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain 110:299\u2013309","journal-title":"Pain"},{"key":"14_CR001425","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1054\/jpai.2002.27138","volume":"3","author":"JG Leem","year":"2002","unstructured":"Leem JG, Bove GM (2002) Mid-axonal tumor necrosis factor-alpha induces ectopic activity in a subset of slowly conducting cutaneous and deep afferent neurons. J Pain 3:45\u201349","journal-title":"J Pain"},{"key":"14_CR001426","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0306-4522(97)00147-4","volume":"81","author":"LS Sorkin","year":"1997","unstructured":"Sorkin LS, Xiao WH, Wagner R, Myers RR (1997) Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience 81:255\u2013262","journal-title":"Neuroscience"},{"key":"14_CR001427","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00586-005-0058-8","volume":"15","author":"AC Ozaktay","year":"2006","unstructured":"Ozaktay AC, Kallakuri S, Takebayashi T, Cavanaugh JM, Asik I, DeLeo JA, Weinstein JN (2006) Effects of interleukin-1 beta, \u00adinterleukin-6, and tumor necrosis factor on \u00adsensitivity of dorsal root ganglion and peripheral receptive fields in rats. Eur Spine J 15:1529\u20131537","journal-title":"Eur Spine J"},{"key":"14_CR001428","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jpain.2007.10.012","volume":"9","author":"A Dilley","year":"2008","unstructured":"Dilley A, Bove GM (2008) Resolution of inflammation-induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors. J Pain 9:185\u2013192","journal-title":"J Pain"},{"key":"14_CR001429","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1113\/jphysiol.2007.144105","volume":"586","author":"A Dilley","year":"2008","unstructured":"Dilley A, Bove GM (2008) Disruption of axoplasmic transport induces mechanical sensitivity in intact rat C-fibre nociceptor axons. J Physiol 586:593\u2013604","journal-title":"J Physiol"},{"key":"14_CR001430","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1460-9568.2006.04606.x","volume":"23","author":"WM Campana","year":"2006","unstructured":"Campana WM, Li X, Shubayev VI, Angert M, Cai K, Myers RR (2006) Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury. Eur J Neurosci 23:617\u2013626","journal-title":"Eur J Neurosci"},{"key":"14_CR001431","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1046\/j.1460-9568.2003.02875.x","volume":"18","author":"WM Campana","year":"2003","unstructured":"Campana WM, Myers RR (2003) Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury. Eur J Neurosci 18:1497\u20131506","journal-title":"Eur J Neurosci"},{"key":"14_CR001432","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1097\/ALN.0b013e31822fcefd","volume":"115","author":"M Swartjes","year":"2011","unstructured":"Swartjes M, Morariu A, Niesters M, Brines M, Cerami A, Aarts L, Dahan A (2011) ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and beta-common receptor knockout mice. Anesthesiology 115:1084\u20131092\n33.Pulman KG, Smith M, Mengozzi M, Ghezzi P, Dilley A (2012) The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model. Neuroscience http:\/\/dx.doi.org\/10.1016\/j.neuroscience.2012.12.022 [Epub ahead of print]","journal-title":"Anesthesiology"}],"container-title":["Methods in Molecular Biology","Tissue-Protective Cytokines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-308-4_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:57:43Z","timestamp":1725616663000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-308-4_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781627033077","9781627033084"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-308-4_14","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"13 February 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}