{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:42:04Z","timestamp":1789274524929,"version":"build-2803163510"},"publisher-location":"Totowa, NJ","reference-count":15,"publisher":"Humana Press","isbn-type":[{"value":"9781627033565","type":"print"},{"value":"9781627033572","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-62703-357-2_1","type":"book-chapter","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T15:16:08Z","timestamp":1365434168000},"page":"1-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Quantitative BCR-ABL1 RQ-PCR Fusion Transcript Monitoring in Chronic Myelogenous Leukemia"],"prefix":"10.1007","author":[{"given":"Franklin R.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole B.","family":"Rempfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Press","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"1_CR00011","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1182\/blood-2006-02-005686","volume":"108","author":"M Baccarani","year":"2006","unstructured":"Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al (2006) Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet. Blood 108:1809\u20131820","journal-title":"Blood"},{"key":"1_CR00012","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","volume":"110","author":"T O\u2019Hare","year":"2007","unstructured":"O\u2019Hare T, Eide CA, Deininger MW (2007) Bcr-Abl kinase domain mutations, drug resistance and the road to a cure of chronic myeloid leukemia. Blood 110:2242\u20132249","journal-title":"Blood"},{"key":"1_CR00013","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0889-8588(05)70198-2","volume":"15","author":"JP Radich","year":"2001","unstructured":"Radich JP (2001) Philadelphia chromosome-positive acute lymphocytic leukemia. Hematol Oncol Clin North Am 15:21\u201336","journal-title":"Hematol Oncol Clin North Am"},{"key":"1_CR00014","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"BJ Druker","year":"2001","unstructured":"Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM et al (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031\u20131037","journal-title":"N Engl J Med"},{"key":"1_CR00015","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1056\/NEJMoa030513","volume":"349","author":"TP Hughes","year":"2003","unstructured":"Hughes TP, Kaeda J, Branford S, Rudzki Z, Hochhaus A, Hensley ML et al (2003) Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 349:1423\u20131432","journal-title":"N Engl J Med"},{"key":"1_CR00016","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker BJ, Guilhot F, O\u2019Brien SG, Gathmann I, Kantarjian H, Gattermann N et al (2006) Five-Year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355:2408\u20132417","journal-title":"N Engl J Med"},{"key":"1_CR00017","doi-asserted-by":"publisher","first-page":"6136","DOI":"10.1158\/1078-0432.CCR-07-1112","volume":"13","author":"RD Press","year":"2007","unstructured":"Press RD, Galderisi C, Yang R, Rempfer C, Willis SG, Mauro MJ et al (2007) A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with CML with an imatinib-induced complete cytogenetic response (CCR). Clin Cancer Res 13:6136\u20136143","journal-title":"Clin Cancer Res"},{"key":"1_CR00018","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1182\/blood-2008-08-173674","volume":"114","author":"RD Press","year":"2009","unstructured":"Press RD, Willis SG, Laudadio J, Mauro MJ, Deininger MW (2009) Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib. Blood 114:2598\u20132605","journal-title":"Blood"},{"key":"1_CR00019","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1182\/blood.V82.6.1929.1929","volume":"82","author":"NC Cross","year":"1993","unstructured":"Cross NC, Feng L, Chase A, Bungey J, Hughes TP, Goldman JM (1993) Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation. Blood 82:1929\u20131936","journal-title":"Blood"},{"key":"1_CR000110","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1182\/blood-2005-11-4406","volume":"107","author":"RD Press","year":"2006","unstructured":"Press RD, Love Z, Tronnes AA, Yang R, Tran T, Mongoue-Tchokote S et al (2006) BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib-treated patients with CML. Blood 107:4250\u20134256","journal-title":"Blood"},{"key":"1_CR000111","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1182\/blood-2008-04-150680","volume":"112","author":"S Branford","year":"2008","unstructured":"Branford S, Fletcher L, Cross NC, Muller MC, Hochhaus A, Kim DW et al (2008) Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials. Blood 112:3330\u20133338","journal-title":"Blood"},{"key":"1_CR000112","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1182\/blood-2006-01-0092","volume":"108","author":"TP Hughes","year":"2006","unstructured":"Hughes TP, Deininger MW, Hochhaus A, Branford S, Radich JP, Kaeda J et al (2006) Monitoring CML patients responding to treatment with tyrosine kinase inhibitors - Review and recommendations for \u2018harmonizing\u2019 current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 108:28\u201337","journal-title":"Blood"},{"key":"1_CR000113","doi-asserted-by":"publisher","first-page":"e111","DOI":"10.1182\/blood-2010-06-291641","volume":"116","author":"H White","year":"2010","unstructured":"White H, Matejtschuk P, Rigsby P, Gabert J, Lin F, Wang L et al (2010) Establishment of the first World Health Organization international genetic reference panel for quantitation of BCR-ABL mRNA. Blood 116:e111\u2013e117","journal-title":"Blood"},{"key":"1_CR000114","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/sj.leu.2401566","volume":"13","author":"M Emig","year":"1999","unstructured":"Emig M, Saussele S, Wittor H, Weisser A, Reiter A, Willer A et al (1999) Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR. Leukemia 13:1825\u20131832","journal-title":"Leukemia"},{"key":"1_CR000115","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/clinchem\/27.3.493","volume":"27","author":"JO Westgard","year":"1981","unstructured":"Westgard JO, Barry PL, Hunt MR, Groth T (1981) A multi-rule Shewhart chart for quality control in clinical chemistry. Clin Chem 27:493\u2013501","journal-title":"Clin Chem"}],"container-title":["Methods in Molecular Biology","Hematological Malignancies"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-357-2_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T22:19:49Z","timestamp":1595629189000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-62703-357-2_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781627033565","9781627033572"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-357-2_1","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"7 March 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}