{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:13:54Z","timestamp":1788516834866,"version":"build-2803163510"},"publisher-location":"Totowa, NJ","reference-count":21,"publisher":"Humana Press","isbn-type":[{"value":"9781627034371","type":"print"},{"value":"9781627034388","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-62703-438-8_15","type":"book-chapter","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T20:06:10Z","timestamp":1369857970000},"page":"201-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kinetic Analysis of Aggregation Data"],"prefix":"10.1007","author":[{"given":"Regina M.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,20]]},"reference":[{"issue":"18","key":"15_CR00151","doi-asserted-by":"publisher","first-page":"11884","DOI":"10.1073\/pnas.182276099","volume":"99","author":"SM Chen","year":"2002","unstructured":"Chen SM, Ferrone FA, Wetzel R (2002) Huntington\u2019s disease age-of-onset linked to polyglutamine aggregation nucleation. Proc Natl Acad Sci USA 99(18):11884\u201311889. doi:10.1073\/Pnas.182276099","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"43","key":"15_CR00152","doi-asserted-by":"publisher","first-page":"15400","DOI":"10.1073\/pnas.0501651102","volume":"102","author":"AM Bhattacharyya","year":"2005","unstructured":"Bhattacharyya AM, Thakur AK, Wetzel R (2005) Polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction. Proc Natl Acad Sci USA 102(43):15400\u201315405. doi:10.1073\/Pnas.0501651102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"15_CR00153","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nsmb.1992","volume":"18","author":"K Kar","year":"2011","unstructured":"Kar K, Jayaraman M, Sahoo B, Kodali R, Wetzel R (2011) Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent. Nat Struct Mol Biol 18(3):328\u2013336. doi:10.1038\/Nsmb.1992","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"15_CR00154","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jmb.2007.02.058","volume":"368","author":"AM Ellisdon","year":"2007","unstructured":"Ellisdon AM, Pearce MC, Bottomley SP (2007) Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein. J Mol Biol 368(2):595\u2013605. doi:10.1016\/J.Jmb.2007.02.058","journal-title":"J Mol Biol"},{"issue":"43","key":"15_CR00155","doi-asserted-by":"publisher","first-page":"9200","DOI":"10.1021\/bi201155g","volume":"50","author":"JP Bernacki","year":"2011","unstructured":"Bernacki JP, Murphy RM (2011) Length-dependent aggregation of uninterrupted polyalanine peptides. Biochemistry 50(43):9200\u20139211. doi:10.1021\/Bi201155g","journal-title":"Biochemistry"},{"issue":"1","key":"15_CR00156","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1529\/biophysj.104.044149","volume":"88","author":"YD Chen","year":"2005","unstructured":"Chen YD, Bjornson K, Redick SD, Erickson HP (2005) A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. Biophys J 88(1):505\u2013514. doi:10.1529\/Biophysj.104.044149","journal-title":"Biophys J"},{"issue":"3","key":"15_CR00157","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1016\/S0006-3495(01)75831-6","volume":"81","author":"MM Pallitto","year":"2001","unstructured":"Pallitto MM, Murphy RM (2001) A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state. Biophys J 81(3):1805\u20131822","journal-title":"Biophys J"},{"issue":"30","key":"15_CR00158","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.1073\/pnas.0703306104","volume":"104","author":"AM Ruschak","year":"2007","unstructured":"Ruschak AM, Miranker AD (2007) Fiber-dependent amyloid formation as catalysis of an existing reaction pathway. Proc Natl Acad Sci USA 104(30):12341\u201312346. doi:10.1073\/Pnas.0703306104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"15_CR00159","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1002\/jps.22447","volume":"100","author":"RK Brummitt","year":"2011","unstructured":"Brummitt RK, Nesta DP, Chang LQ, Kroetsch AM, Roberts CJ (2011) Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: nucleation and growth kinetics with competing growth mechanisms. J Pharm Sci 100(6):2104\u20132119. doi:10.1002\/Jps.22447","journal-title":"J Pharm Sci"},{"issue":"27","key":"15_CR001510","doi-asserted-by":"publisher","first-page":"7897","DOI":"10.1021\/jp070212j","volume":"111","author":"JM Andrews","year":"2007","unstructured":"Andrews JM, Roberts CJ (2007) A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding. J Phys Chem B 111(27):7897\u20137913. doi:10.1021\/Jp070212j","journal-title":"J Phys Chem B"},{"issue":"19","key":"15_CR001511","doi-asserted-by":"publisher","first-page":"7020","DOI":"10.1021\/jp8083088","volume":"113","author":"Y Li","year":"2009","unstructured":"Li Y, Roberts CJ (2009) Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization. J Phys Chem B 113(19):7020\u20137032. doi:10.1021\/Jp8083088","journal-title":"J Phys Chem B"},{"issue":"7","key":"15_CR001512","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1016\/j.bpj.2008.12.3903","volume":"96","author":"JP Bernacki","year":"2009","unstructured":"Bernacki JP, Murphy RM (2009) Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies. Biophys J 96(7):2871\u20132887. doi:10.1016\/J.Bpj.2008.12.3903","journal-title":"Biophys J"},{"issue":"5","key":"15_CR001513","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.jmb.2004.06.043","volume":"341","author":"KF Dubay","year":"2004","unstructured":"Dubay KF, Pawar AP, Chiti F, Zurdo J, Dobson CM, Vendruscolo M (2004) Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol 341(5):1317\u20131326. doi:10.1016\/J.Jmb.2004.06.043","journal-title":"J Mol Biol"},{"issue":"6","key":"15_CR001514","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nchembio792","volume":"2","author":"DW Colby","year":"2006","unstructured":"Colby DW, Cassady JP, Lin GC, Ingram VM, Wittrup KD (2006) Stochastic kinetics of intracellular huntingtin aggregate formation. Nat Chem Biol 2(6):319\u2013323. doi:10.1038\/Nchembio792","journal-title":"Nat Chem Biol"},{"issue":"20","key":"15_CR001515","doi-asserted-by":"publisher","first-page":"6036","DOI":"10.1021\/bi002555c","volume":"40","author":"L Nielsen","year":"2001","unstructured":"Nielsen L, Khurana R, Coats A, Frokjaer S, Brange J, Vyas S, Uversky VN, Fink AL (2001) Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism. Biochemistry 40(20):6036\u20136046","journal-title":"Biochemistry"},{"issue":"3","key":"15_CR001516","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/protein\/gzm076","volume":"21","author":"BW Koo","year":"2008","unstructured":"Koo BW, Hebda JA, Miranker AD (2008) Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. Protein Eng Des Sel 21(3):147\u2013154. doi:10.1093\/Protein\/Gzm076","journal-title":"Protein Eng Des Sel"},{"issue":"48","key":"15_CR001517","doi-asserted-by":"publisher","first-page":"14503","DOI":"10.1021\/bi061228n","volume":"45","author":"JS Pedersen","year":"2006","unstructured":"Pedersen JS, Dikov D, Otzen DE (2006) N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon. Bio-chemistry 45(48):14503\u201314512. doi:10.1021\/ Bi061228n","journal-title":"Biochemistry"},{"issue":"8","key":"15_CR001518","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1021\/bi701899y","volume":"47","author":"AM Morris","year":"2008","unstructured":"Morris AM, Watzky MA, Agar JN, Finke RG (2008) Fitting neurological protein aggregation kinetic data via a 2-step, Minimal\/\u201dOckham\u2019s Razor\u201d model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth. Biochemistry 47(8):2413\u20132427. doi:10.1021\/Bi701899y","journal-title":"Biochemistry"},{"issue":"2","key":"15_CR001519","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ab.2004.05.044","volume":"333","author":"M Necula","year":"2004","unstructured":"Necula M, Kuret J (2004) A static laser light scattering assay for surfactant-induced tau fibrillization. Anal Biochem 333(2):205\u2013215. doi:10.1016\/J.Ab.2004.05.044","journal-title":"Anal Biochem"},{"issue":"15","key":"15_CR001520","doi-asserted-by":"publisher","first-page":"5862","DOI":"10.1021\/bi0500123","volume":"44","author":"CN Chirita","year":"2005","unstructured":"Chirita CN, Congdon EE, Yin HS, Kuret J (2005) Triggers of full-length tau aggregation: a role for partially folded intermediates. Bio-chemistry 44(15):5862\u20135872. doi:10.1021\/ Bi0500123","journal-title":"Biochemistry"},{"key":"15_CR001521","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S0076-6879(99)09019-9","volume":"309","author":"F Ferrone","year":"1999","unstructured":"Ferrone F (1999) Analysis of protein aggregation kinetics. Meth Enzymol 309:256\u2013274","journal-title":"Amyloid, Prions, and Other Protein Aggregates"}],"container-title":["Methods in Molecular Biology","Tandem Repeats in Genes, Proteins, and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-438-8_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T16:44:11Z","timestamp":1675961051000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-438-8_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781627034371","9781627034388"],"references-count":21,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-438-8_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"20 April 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}