{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:44Z","timestamp":1793381084606,"version":"4.5.0"},"publisher-location":"Totowa, NJ","reference-count":155,"publisher":"Humana Press","isbn-type":[{"value":"9781627035613","type":"print"},{"value":"9781627035620","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-62703-562-0_3","type":"book-chapter","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T18:36:19Z","timestamp":1373999779000},"page":"27-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["Multisystemic Functions of Alkaline Phosphatases"],"prefix":"10.1007","author":[{"given":"Ren\u00e9","family":"Buchet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Magne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"3_CR00031","doi-asserted-by":"publisher","DOI":"10.1002\/3527608060","volume-title":"Mammalian alkaline phosphatases: from biology to applications in medicine and biotechnology","author":"JL Millan","year":"2006","unstructured":"Millan JL (2006) Mammalian alkaline phosphatases: from biology to applications in medicine and biotechnology. Wiley-VCH, Weinheim"},{"key":"3_CR00032","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.1016\/S0021-9258(18)37885-2","volume":"263","author":"MJ Weiss","year":"1988","unstructured":"Weiss MJ, Ray K, Henthorn PS et\u00a0al (1988) Structure of the human liver\/bone\/kidney alkaline phosphatase gene. J Biol Chem 263:12002\u201312010","journal-title":"J Biol Chem"},{"key":"3_CR00033","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/nar\/17.5.2129","volume":"17","author":"F Kishi","year":"1989","unstructured":"Kishi F, Matsuura S, Kajii T (1989) Nucleotide sequence of the human liver-type alkaline phosphatase cDNA. Nucleic Acids Res 17:2129","journal-title":"Nucleic Acids Res"},{"key":"3_CR00034","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0006-291X(90)91127-E","volume":"168","author":"S Matsuura","year":"1990","unstructured":"Matsuura S, Kishi F, Kajii T (1990) Characterization of a 5\u2032-flanking region of the human liver\/bone\/kidney alkaline phosphatase gene: two kinds of mRNA from a single gene. Biochem Biophys Res Commun 168:993\u20131000","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR00035","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/0006-291X(91)91722-O","volume":"179","author":"M Studer","year":"1991","unstructured":"Studer M, Terao M, Gianni M et\u00a0al (1991) Characterization of a second promoter for the mouse liver\/bone\/kidney-type alkaline phosphatase gene: cell and tissue specific expression. Biochem Biophys Res Commun 179:1352\u20131360","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR00036","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1469-1809.1987.tb01056.x","volume":"51","author":"D Martin","year":"1987","unstructured":"Martin D, Tucker DF, Gorman P et\u00a0al (1987) The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37. Ann Hum Genet 51:145\u2013152","journal-title":"Ann Hum Genet"},{"key":"3_CR00037","first-page":"1025","volume":"41","author":"CA Griffin","year":"1987","unstructured":"Griffin CA, Smith M, Henthorn PS et\u00a0al (1987) Human placental and intestinal alkaline phosphatase genes map to 2q34-q37. Am J Hum Genet 41:1025\u20131034","journal-title":"Am J Hum Genet"},{"key":"3_CR00038","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1073\/pnas.84.5.1234","volume":"84","author":"PS Henthorn","year":"1987","unstructured":"Henthorn PS, Raducha M, Edwards YH et\u00a0al (1987) Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. Proc Natl Acad Sci U S A 84:1234\u20131238","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR00039","doi-asserted-by":"crossref","first-page":"12020","DOI":"10.1016\/S0021-9258(18)37887-6","volume":"263","author":"BJ Knoll","year":"1988","unstructured":"Knoll BJ, Rothblum KN, Longley M (1988) Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5\u2032 flanking region by deletion\/substitution. J Biol Chem 263:12020\u201312027","journal-title":"J Biol Chem"},{"key":"3_CR000310","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1073\/pnas.85.9.3024","volume":"85","author":"JL Mill\u00e1n","year":"1988","unstructured":"Mill\u00e1n JL, Manes T (1988) Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. Proc Natl Acad Sci U S A 85:3024\u20133028","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000311","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1073\/pnas.83.11.3781","volume":"83","author":"CE Ovitt","year":"1986","unstructured":"Ovitt CE, Strauss AW, Alpers DH et\u00a0al (1986) Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. Proc Natl Acad Sci U S A 83:3781\u20133785","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000312","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S0021-9258(19)75754-8","volume":"262","author":"JR Gum","year":"1987","unstructured":"Gum JR, Kam WK, Byrd JC et\u00a0al (1987) Effects of sodium butyrate on human colonic adenocarcinoma cells. Induction of placental-like alkaline phosphatase. J Biol Chem 262:1092\u20131097","journal-title":"J Biol Chem"},{"key":"3_CR000313","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1021\/bi00386a052","volume":"26","author":"JY Chou","year":"1987","unstructured":"Chou JY, Takahashi S (1987) Control of placental alkaline phosphatase gene expression in HeLa cells: induction of synthesis by prednisolone and sodium butyrate. Biochemistry 26:3596\u20133602","journal-title":"Biochemistry"},{"key":"3_CR000314","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF01534406","volume":"14","author":"M Terao","year":"1988","unstructured":"Terao M, Pravtcheva D, Ruddle FH et\u00a0al (1988) Mapping of gene encoding mouse placental alkaline phosphatase to chromosome 4. Somat Cell Mol Genet 14:211\u2013215","journal-title":"Somat Cell Mol Genet"},{"key":"3_CR000315","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/0888-7543(90)90042-S","volume":"8","author":"T Manes","year":"1990","unstructured":"Manes T, Glade K, Ziomek CA et\u00a0al (1990) Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes. Genomics 8:541\u2013554","journal-title":"Genomics"},{"key":"3_CR000316","doi-asserted-by":"publisher","first-page":"G1068","DOI":"10.1152\/ajpgi.00073.2007","volume":"293","author":"S Narisawa","year":"2007","unstructured":"Narisawa S, Hoylaerts MF, Doctor KS et\u00a0al (2007) A novel phosphatase upregulated in Akp3 knockout mice. Am J Physiol Gastrointest Liver Physiol 293:G1068\u2013G1077","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3_CR000317","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1432-0436.1985.tb00308.x","volume":"29","author":"H Merchant-Larios","year":"1985","unstructured":"Merchant-Larios H, Mendlovic F, Alvarez-Buylla A (1985) Characterization of alkaline phosphatase from primordial germ cells and ontogenesis of this enzyme in the mouse. Differentiation 29:145\u2013151","journal-title":"Differentiation"},{"key":"3_CR000318","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1242\/dev.121.5.1487","volume":"121","author":"GR MacGregor","year":"1995","unstructured":"MacGregor GR, Zambrowicz BP, Soriano P (1995) Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development 121:1487\u20131496","journal-title":"Development"},{"key":"3_CR000319","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/aja.1002010306","volume":"201","author":"S Narisawa","year":"1994","unstructured":"Narisawa S, Hasegawa H, Watanabe K et\u00a0al (1994) Stage-specific expression of alkaline phosphatase during neural development in the mouse. Dev Dyn 201:227\u2013235","journal-title":"Dev Dyn"},{"key":"3_CR000320","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s004180050103","volume":"107","author":"K Hoshi","year":"1997","unstructured":"Hoshi K, Amizuka N, Oda K et\u00a0al (1997) Immunolocalization of tissue non-specific alkaline phosphatase in mice. Histochem Cell Biol 107:183\u2013191","journal-title":"Histochem Cell Biol"},{"key":"3_CR000321","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/cercor\/bhh021","volume":"14","author":"C Fonta","year":"2004","unstructured":"Fonta C, N\u00e9gyessy L, Renaud L et\u00a0al (2004) Areal and subcellular localization of the ubiquitous alkaline phosphatase in the primate cerebral cortex: evidence for a role in neurotransmission. Cereb Cortex 14:595\u2013609","journal-title":"Cereb Cortex"},{"key":"3_CR000322","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00441-008-0681-x","volume":"334","author":"D Langer","year":"2008","unstructured":"Langer D, Hammer K, Koszalka P et\u00a0al (2008) Distribution of ectonucleotidases in the rodent brain revisited. Cell Tissue Res 334:199\u2013217","journal-title":"Cell Tissue Res"},{"issue":"2","key":"3_CR000323","first-page":"459","volume":"349","author":"I Brun-Heath","year":"2011","unstructured":"Brun-Heath I, Ermonval M, Chabrol E et\u00a0al (2011) Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues. Cell Tissue Res 343:521\u2013536","journal-title":"Cell Tissue Res"},{"key":"3_CR000324","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.neuroscience.2010.10.049","volume":"172","author":"L N\u00e9gyessy","year":"2011","unstructured":"N\u00e9gyessy L, Xiao J, K\u00e1ntor O et\u00a0al (2011) Layer-specific activity of tissue non-specific alkaline phosphatase in the human neocortex. Neuroscience 172:406\u2013418","journal-title":"Neuroscience"},{"key":"3_CR000325","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1242\/dev.110.2.555","volume":"110","author":"AC Hahnel","year":"1990","unstructured":"Hahnel AC, Rappolee DA, Millan JL et\u00a0al (1990) Two alkaline phosphatase genes are expressed during early development in the mouse embryo. Development 110:555\u2013564","journal-title":"Development"},{"key":"3_CR000326","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2605.1987.tb00162.x","volume":"10","author":"J Hustin","year":"1987","unstructured":"Hustin J, Collette J, Franchimont P (1987) Immunohistochemical demonstration of placental alkaline phosphatase in various states of testicular development and in germ cell tumours. Int J Androl 10:29\u201335","journal-title":"Int J Androl"},{"key":"3_CR000327","first-page":"1506","volume":"40","author":"CH Chang","year":"1980","unstructured":"Chang CH, Angellis D, Fishman WH (1980) Presence of the rare D-variant heat-stable, placental-type alkaline phosphatase in normal human testis. Cancer Res 40:1506\u20131510","journal-title":"Cancer Res"},{"key":"3_CR000328","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0009-8981(82)90046-8","volume":"125","author":"DJ Goldstein","year":"1982","unstructured":"Goldstein DJ, Rogers C, Harris H (1982) A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus. Clin Chim Acta 125:63\u201375","journal-title":"Clin Chim Acta"},{"key":"3_CR000329","first-page":"2268","volume":"36","author":"L Fishman","year":"1976","unstructured":"Fishman L, Miyayama H, Driscoll SG et\u00a0al (1976) Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer. Cancer Res 36:2268\u20132273","journal-title":"Cancer Res"},{"key":"3_CR000330","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1177\/33.12.4067276","volume":"33","author":"R Jemmerson","year":"1985","unstructured":"Jemmerson R, Klier FG, Fishman WH (1985) Clustered distribution of human placental alkaline phosphatase on the surface of both placental and cancer cells. Electron microscopic observations using gold-labeled antibodies. J Histochem Cytochem 33:1227\u20131234","journal-title":"J Histochem Cytochem"},{"key":"3_CR000331","doi-asserted-by":"publisher","first-page":"22992","DOI":"10.1074\/jbc.M202298200","volume":"277","author":"A Kozlenkov","year":"2002","unstructured":"Kozlenkov A, Manes T, Hoylaerts MF et\u00a0al (2002) Function assignment to conserved residues in mammalian alkaline phosphatases. J Biol Chem 277:22992\u201322999","journal-title":"J Biol Chem"},{"key":"3_CR000332","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1359\/JBMR.040608","volume":"19","author":"A Kozlenkov","year":"2004","unstructured":"Kozlenkov A, Le Du MH, Cuniasse P et\u00a0al (2004) Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. J Bone Miner Res 19:1862\u20131872","journal-title":"J Bone Miner Res"},{"key":"3_CR000333","doi-asserted-by":"publisher","first-page":"49808","DOI":"10.1074\/jbc.M207394200","volume":"277","author":"MH Le Du","year":"2002","unstructured":"Le Du MH, Millan JL (2002) Structural evidence of functional divergence in human alkaline phosphatases. J Biol Chem 277:49808\u201349814","journal-title":"J Biol Chem"},{"key":"3_CR000334","doi-asserted-by":"publisher","first-page":"22781","DOI":"10.1074\/jbc.272.36.22781","volume":"272","author":"MF Hoylaerts","year":"1997","unstructured":"Hoylaerts MF, Manes T, Mill\u00e1n JL (1997) Mammalian alkaline phosphatases are allosteric enzymes. J Biol Chem 272:22781\u201322787","journal-title":"J Biol Chem"},{"key":"3_CR000335","doi-asserted-by":"publisher","first-page":"9756","DOI":"10.1021\/bi052471+","volume":"45","author":"MF Hoylaerts","year":"2006","unstructured":"Hoylaerts MF, Ding L, Narisawa S et\u00a0al (2006) Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment. Biochemistry 45:9756\u20139766","journal-title":"Biochemistry"},{"key":"3_CR000336","doi-asserted-by":"crossref","first-page":"25409","DOI":"10.1016\/S0021-9258(19)74407-X","volume":"268","author":"M Bossi","year":"1993","unstructured":"Bossi M, Hoylaerts MF, Mill\u00e1n JL (1993) Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases. J Biol Chem 268:25409\u201325416","journal-title":"J Biol Chem"},{"key":"3_CR000337","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.bone.2009.07.009","volume":"45","author":"LC Halling","year":"2009","unstructured":"Halling LC, Narisawa S, Mill\u00e1n JL et\u00a0al (2009) Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms. Bone 45:987\u2013993","journal-title":"Bone"},{"key":"3_CR000338","doi-asserted-by":"publisher","first-page":"37289","DOI":"10.1074\/jbc.M504260200","volume":"280","author":"L Zhang","year":"2005","unstructured":"Zhang L, Balcerzak M, Radisson J et\u00a0al (2005) Phosphodiesterase activity of alkaline phosphatase in ATP-initiated Ca2+ and phosphate deposition in isolated chicken matrix vesicles. J Biol Chem 280:37289\u201337296","journal-title":"J Biol Chem"},{"key":"3_CR000339","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0169-6009(92)90877-G","volume":"19","author":"DC Morris","year":"1992","unstructured":"Morris DC, Masuhara K, Takaoka K et\u00a0al (1992) Immunolocalization of alkaline phosphatase in osteoblasts and matrix vesicles of human fetal bone. Bone Miner 19:287\u2013298","journal-title":"Bone Miner"},{"key":"3_CR000340","doi-asserted-by":"crossref","first-page":"14368","DOI":"10.1016\/S0021-9258(18)68229-8","volume":"263","author":"K Hawrylak","year":"1988","unstructured":"Hawrylak K, Stinson RA (1988) The solubilization of tetrameric alkaline phosphatase from human liver and its conversion into various forms by phosphatidylinositol phospholipase C or proteolysis. J Biol Chem 263:14368\u201314373","journal-title":"J Biol Chem"},{"key":"3_CR000341","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0009-8981(01)00584-8","volume":"311","author":"DJ Anh","year":"2001","unstructured":"Anh DJ, Eden A, Farley JR (2001) Quantitation of soluble and skeletal alkaline phosphatase, and insoluble alkaline phosphatase anchor-hydrolase activities in human serum. Clin Chim Acta 311:137\u2013148","journal-title":"Clin Chim Acta"},{"key":"3_CR000342","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1073\/pnas.85.4.980","volume":"85","author":"MG Low","year":"1988","unstructured":"Low MG, Prasad AR (1988) A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma. Proc Natl Acad Sci U S A 85:980\u2013984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000343","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1126\/science.2443973","volume":"238","author":"MA Davitz","year":"1987","unstructured":"Davitz MA, Hereld D, Shak S et\u00a0al (1987) A glycan-phosphatidylinositol-specific phospholipase D in human serum. Science 238:81\u201384","journal-title":"Science"},{"key":"3_CR000344","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1359\/jbmr.1997.12.2.210","volume":"12","author":"P Magnusson","year":"1997","unstructured":"Magnusson P, Degerblad M, S\u00e4\u00e4f M et\u00a0al (1997) Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency. J Bone Miner Res 12:210\u2013220","journal-title":"J Bone Miner Res"},{"key":"3_CR000345","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0005-2744(81)90017-6","volume":"661","author":"GP Smith","year":"1981","unstructured":"Smith GP, Peters TJ (1981) Subcellular localization and properties of pyridoxal phosphate phosphatases of human polymorphonuclear leukocytes and their relationship to acid and alkaline phosphatase. Biochim Biophys Acta 661:287\u2013294","journal-title":"Biochim Biophys Acta"},{"key":"3_CR000346","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/BF01006240","volume":"15","author":"PD Wilson","year":"1983","unstructured":"Wilson PD, Smith GP, Peters TJ (1983) Pyridoxal 5\u2032-phosphate: a possible physiological substrate for alkaline phosphatase in human neutrophils. Histochem J 15:257\u2013264","journal-title":"Histochem J"},{"key":"3_CR000347","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1126\/science.3276003","volume":"239","author":"MG Low","year":"1988","unstructured":"Low MG, Saltiel AR (1988) Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science 239:268\u2013275","journal-title":"Science"},{"key":"3_CR000348","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ng0995-45","volume":"11","author":"KG Waymire","year":"1995","unstructured":"Waymire KG, Mahuren JD, Jaje JM et\u00a0al (1995) Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat Genet 11:45\u201351","journal-title":"Nat Genet"},{"key":"3_CR000349","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1016\/S0021-9258(19)63811-1","volume":"245","author":"HL Fleshood","year":"1970","unstructured":"Fleshood HL, Pitot HC (1970) The metabolism of O-phosphorylethanolamine in animal tissues. I. O-phosphorylethanolamine phospho-lyase: partial purification and characterization. J Biol Chem 245:4414\u20134420","journal-title":"J Biol Chem"},{"key":"3_CR000350","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/labinvest.2011.83","volume":"91","author":"P Lencel","year":"2011","unstructured":"Lencel P, Delplace S, Pilet P et\u00a0al (2011) Cell-specific effects of TNF-\u03b1 and IL-1\u03b2 on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification. Lab Invest 91:1434\u20131442","journal-title":"Lab Invest"},{"key":"3_CR000351","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1073\/pnas.0914360107","volume":"107","author":"U Krause","year":"2010","unstructured":"Krause U, Harris S, Green A et\u00a0al (2010) Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci U S A 107:4147\u20134152","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000352","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.bbrc.2012.12.036","volume":"430","author":"A Briolay","year":"2013","unstructured":"Briolay A, Lencel P, Bessueille L et\u00a0al (2013) Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-\u03b1 in human mesenchymal stem cells. Biochem Biophys Res Commun 430:1072\u20131077","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR000353","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.bone.2011.06.006","volume":"49","author":"J Delgado-Calle","year":"2011","unstructured":"Delgado-Calle J, Sa\u00f1udo C, S\u00e1nchez-Verde L et\u00a0al (2011) Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage. Bone 49:830\u2013838","journal-title":"Bone"},{"key":"3_CR000354","doi-asserted-by":"crossref","unstructured":"Bernard GW (1978) Ultrastructural localization of alkaline phosphatase in initial intramembranous osteogenesis. Clin Orthop Relat Res 218\u2013225","DOI":"10.1097\/00003086-197809000-00042"},{"key":"3_CR000355","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/0006-2952(93)90338-W","volume":"46","author":"A Togari","year":"1993","unstructured":"Togari A, Arakawa S, Arai M et\u00a0al (1993) Inhibition of in vitro mineralization in osteoblastic cells and in mouse tooth germ by phosphatidylinositol-specific phospholipase C. Biochem Pharmacol 46:1668\u20131670","journal-title":"Biochem Pharmacol"},{"key":"3_CR000356","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/0020-711X(88)90301-1","volume":"25","author":"HH Hsu","year":"1993","unstructured":"Hsu HH, Morris DC, Davis L et\u00a0al (1993) In vitro Ca deposition by rat matrix vesicles: is the membrane association of alkaline phosphatase essential for matrix vesicle-mediated calcium deposition? Int J Biochem 25:1737\u20131742","journal-title":"Int J Biochem"},{"key":"3_CR000357","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1254\/jjp.88.262","volume":"88","author":"Y Sugawara","year":"2002","unstructured":"Sugawara Y, Suzuki K, Koshikawa M et\u00a0al (2002) Necessity of enzymatic activity of alkaline phosphatase for mineralization of osteoblastic cells. Jpn J Pharmacol 88:262\u2013269","journal-title":"Jpn J Pharmacol"},{"key":"3_CR000358","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0022-3476(82)80061-9","volume":"101","author":"MP Whyte","year":"1982","unstructured":"Whyte MP, Valdes R, Ryan LM et\u00a0al (1982) Infantile hypophosphatasia: enzyme replacement therapy by intravenous infusion of alkaline phosphatase-rich plasma from patients with Paget bone disease. J Pediatr 101:379\u2013386","journal-title":"J Pediatr"},{"key":"3_CR000359","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0022-3476(84)80079-7","volume":"105","author":"MP Whyte","year":"1984","unstructured":"Whyte MP, McAlister WH, Patton LS et\u00a0al (1984) Enzyme replacement therapy for infantile hypophosphatasia attempted by intravenous infusions of alkaline phosphatase-rich Paget plasma: results in three additional patients. J Pediatr 105:926\u2013933","journal-title":"J Pediatr"},{"key":"3_CR000360","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1651-2227.1989.tb11297.x","volume":"360","author":"M Weninger","year":"1989","unstructured":"Weninger M, Stinson RA, Plenk H et\u00a0al (1989) Biochemical and morphological effects of human hepatic alkaline phosphatase in a neonate with hypophosphatasia. Acta Paediatr Scand Suppl 360:154\u2013160","journal-title":"Acta Paediatr Scand Suppl"},{"key":"3_CR000361","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1359\/jbmr.071213","volume":"23","author":"JL Mill\u00e1n","year":"2008","unstructured":"Mill\u00e1n JL, Narisawa S, Lemire I et\u00a0al (2008) Enzyme replacement therapy for murine hypophosphatasia. J Bone Miner Res 23:777\u2013787","journal-title":"J Bone Miner Res"},{"key":"3_CR000362","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1056\/NEJMoa1106173","volume":"366","author":"MP Whyte","year":"2012","unstructured":"Whyte MP, Greenberg CR, Salman NJ et\u00a0al (2012) Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med 366:904\u2013913","journal-title":"N Engl J Med"},{"key":"3_CR000363","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng.653","volume":"42","author":"PM Krawitz","year":"2010","unstructured":"Krawitz PM, Schweiger MR, R\u00f6delsperger C et\u00a0al (2010) Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet 42:827\u2013829","journal-title":"Nat Genet"},{"key":"3_CR000364","doi-asserted-by":"publisher","first-page":"7666","DOI":"10.1073\/pnas.85.20.7666","volume":"85","author":"MJ Weiss","year":"1988","unstructured":"Weiss MJ, Cole DE, Ray K et\u00a0al (1988) A missense mutation in the human liver\/bone\/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia. Proc Natl Acad Sci U S A 85:7666\u20137669","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000365","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1749-6632.2010.05387.x","volume":"1192","author":"MP Whyte","year":"2010","unstructured":"Whyte MP (2010) Physiological role of alkaline phosphatase explored in hypophosphatasia. Ann N Y Acad Sci 1192:190\u2013200","journal-title":"Ann N Y Acad Sci"},{"key":"3_CR000366","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00005792-198401000-00002","volume":"63","author":"MD Fallon","year":"1984","unstructured":"Fallon MD, Teitelbaum SL, Weinstein RS et\u00a0al (1984) Hypophosphatasia: clinicopathologic comparison of the infantile, childhood, and adult forms. Medicine (Baltimore) 63:12\u201324","journal-title":"Medicine (Baltimore)"},{"key":"3_CR000367","first-page":"1555","volume":"151","author":"HC Anderson","year":"1997","unstructured":"Anderson HC, Hsu HH, Morris DC et\u00a0al (1997) Matrix vesicles in osteomalacic hypophosphatasia bone contain apatite-like mineral crystals. Am J Pathol 151:1555\u20131561","journal-title":"Am J Pathol"},{"key":"3_CR000368","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jbmr.195","volume":"26","author":"MC Yadav","year":"2011","unstructured":"Yadav MC, Sim\u00e3o AM, Narisawa S et\u00a0al (2011) Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res 26:286\u2013297","journal-title":"J Bone Miner Res"},{"key":"3_CR000369","doi-asserted-by":"crossref","unstructured":"Mill\u00e1n JL (2012) The role of phosphatases in the initiation of skeletal mineralization. Calcif Tissue Int (10.1007\/s00223-012-9672-8)","DOI":"10.1007\/s00223-012-9672-8"},{"key":"3_CR000370","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1359\/jbmr.1999.14.12.2015","volume":"14","author":"KN Fedde","year":"1999","unstructured":"Fedde KN, Blair L, Silverstein J et\u00a0al (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 14:2015\u20132026","journal-title":"J Bone Miner Res"},{"key":"3_CR000371","doi-asserted-by":"publisher","first-page":"9788","DOI":"10.1021\/bi060847t","volume":"45","author":"JG Zalatan","year":"2006","unstructured":"Zalatan JG, Fenn TD, Brunger AT et\u00a0al (2006) Structural and functional comparisons of nucleotide pyrophosphatase\/phosphodiesterase and alkaline phosphatase: implications for mechanism and evolution. Biochemistry 45:9788\u20139803","journal-title":"Biochemistry"},{"key":"3_CR000372","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1359\/jbmr.091023","volume":"25","author":"P Ciancaglini","year":"2010","unstructured":"Ciancaglini P, Yadav MC, Sim\u00e3o AM et\u00a0al (2010) Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles. J Bone Miner Res 25:716\u2013723","journal-title":"J Bone Miner Res"},{"key":"3_CR000373","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1101\/gad.1276205","volume":"19","author":"M Murshed","year":"2005","unstructured":"Murshed M, Harmey D, Mill\u00e1n JL et\u00a0al (2005) Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 19:1093\u20131104","journal-title":"Genes Dev"},{"key":"3_CR000374","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1042\/bj1041011","volume":"104","author":"HN Fernley","year":"1967","unstructured":"Fernley HN, Walker PG (1967) Studies on alkaline phosphatase. Inhibition by phosphate derivatives and the substrate specificity. Biochem J 104:1011\u20131018","journal-title":"Biochem J"},{"key":"3_CR000375","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1073\/pnas.142063399","volume":"99","author":"L Hessle","year":"2002","unstructured":"Hessle L, Johnson KA, Anderson HC et\u00a0al (2002) Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A 99:9445\u20139449","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR000376","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S0002-9440(10)63208-7","volume":"164","author":"D Harmey","year":"2004","unstructured":"Harmey D, Hessle L, Narisawa S et\u00a0al (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 164:1199\u20131209","journal-title":"Am J Pathol"},{"key":"3_CR000377","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.joca.2008.05.020","volume":"17","author":"C Thouverey","year":"2009","unstructured":"Thouverey C, Bechkoff G, Pikula S et\u00a0al (2009) Inorganic pyrophosphate as a regulator of hydroxyapatite or calcium pyrophosphate dihydrate mineral deposition by matrix vesicles. Osteoarthritis Cartilage 17:64\u201372","journal-title":"Osteoarthritis Cartilage"},{"key":"3_CR000378","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/jbmr.1767","volume":"28","author":"B Foster","year":"2013","unstructured":"Foster B, Nagatomo K, Tso H et\u00a0al (2013) Tooth root dentin mineralization defects in a mouse model of hypophosphatasia. J Bone Miner Res 28:271\u2013282","journal-title":"J Bone Miner Res"},{"key":"3_CR000379","doi-asserted-by":"publisher","first-page":"e38393","DOI":"10.1371\/journal.pone.0038393","volume":"7","author":"BL Foster","year":"2012","unstructured":"Foster BL, Nagatomo KJ, Nociti FH et\u00a0al (2012) Central role of pyrophosphate in acellular cementum formation. PLoS One 7:e38393","journal-title":"PLoS One"},{"key":"3_CR000380","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1177\/0022034510393517","volume":"90","author":"MD McKee","year":"2011","unstructured":"McKee MD, Nakano Y, Masica DL et\u00a0al (2011) Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia. J Dent Res 90:470\u2013476","journal-title":"J Dent Res"},{"key":"3_CR000381","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1002\/jbmr.1619","volume":"27","author":"MC Yadav","year":"2012","unstructured":"Yadav MC, de Oliveira RC, Foster BL et\u00a0al (2012) Enzyme replacement prevents enamel defects in hypophosphatasia mice. J Bone Miner Res 27:1722\u20131734","journal-title":"J Bone Miner Res"},{"key":"3_CR000382","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1359\/jbmr.2003.18.1.117","volume":"18","author":"W Tesch","year":"2003","unstructured":"Tesch W, Vandenbos T, Roschgr P et\u00a0al (2003) Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase. J Bone Miner Res 18:117\u2013125","journal-title":"J Bone Miner Res"},{"key":"3_CR000383","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.pediatrneurol.2005.08.020","volume":"34","author":"MD Thompson","year":"2006","unstructured":"Thompson MD, Killoran A, Percy ME et\u00a0al (2006) Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder? Pediatr Neurol 34:303\u2013307","journal-title":"Pediatr Neurol"},{"key":"3_CR000384","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/01.wco.0000218230.81301.12","volume":"19","author":"SM Gospe","year":"2006","unstructured":"Gospe SM (2006) Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. Curr Opin Neurol 19:148\u2013153","journal-title":"Curr Opin Neurol"},{"key":"3_CR000385","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<432::AID-AJA13>3.0.CO;2-1","volume":"208","author":"S Narisawa","year":"1997","unstructured":"Narisawa S, Fr\u00f6hlander N, Mill\u00e1n JL (1997) Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn 208:432\u2013446","journal-title":"Dev Dyn"},{"key":"3_CR000386","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH722>3.0.CO;2-Y","volume":"193","author":"S Narisawa","year":"2001","unstructured":"Narisawa S, Wennberg C, Mill\u00e1n JL (2001) Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization. J Pathol 193:125\u2013133","journal-title":"J Pathol"},{"key":"3_CR000387","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/j.bone.2007.01.020","volume":"40","author":"S Baumgartner-Sigl","year":"2007","unstructured":"Baumgartner-Sigl S, Haberlandt E, Mumm S et\u00a0al (2007) Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. Bone 40:1655\u20131661","journal-title":"Bone"},{"key":"3_CR000388","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1750-1172-2-40","volume":"2","author":"E Mornet","year":"2007","unstructured":"Mornet E (2007) Hypophosphatasia. Orphanet J Rare Dis 2:40","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"3_CR000389","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00441-012-1455-z","volume":"349","author":"J Hanics","year":"2012","unstructured":"Hanics J, Barna J, Xiao J et\u00a0al (2012) Ablation of TNAP function compromises myelination and synaptogenesis in the mouse brain. Cell Tissue Res 349(2):459\u2013471","journal-title":"Cell Tissue Res"},{"key":"3_CR000390","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neulet.2010.09.013","volume":"485","author":"V Kermer","year":"2010","unstructured":"Kermer V, Ritter M, Albuquerque B et\u00a0al (2010) Knockdown of tissue nonspecific alkaline phosphatase impairs neural stem cell proliferation and differentiation. Neurosci Lett 485:208\u2013211","journal-title":"Neurosci Lett"},{"key":"3_CR000391","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1091\/mbc.E10-09-0740","volume":"22","author":"M D\u00edez-Zaera","year":"2011","unstructured":"D\u00edez-Zaera M, D\u00edaz-Hern\u00e1ndez JI, Hern\u00e1ndez-\u00c1lvarez E et\u00a0al (2011) Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons. Mol Biol Cell 22:1014\u20131024","journal-title":"Mol Biol Cell"},{"key":"3_CR000392","doi-asserted-by":"publisher","first-page":"e6497","DOI":"10.1371\/journal.pone.0006497","volume":"4","author":"M Ermonval","year":"2009","unstructured":"Ermonval M, Baudry A, Baychelier F et\u00a0al (2009) The cellular prion protein interacts with the tissue non-specific alkaline phosphatase in membrane microdomains of bioaminergic neuronal cells. PLoS One 4:e6497","journal-title":"PLoS One"},{"key":"3_CR000393","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/0016-5085(81)90123-2","volume":"80","author":"DE Hatoff","year":"1981","unstructured":"Hatoff DE, Hardison WG (1981) Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology 80:666\u2013672","journal-title":"Gastroenterology"},{"key":"3_CR000394","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/hep.1840020407","volume":"2","author":"DE Hatoff","year":"1982","unstructured":"Hatoff DE, Hardison WG (1982) Bile acid-dependent secretion of alkaline phosphatase in rat bile. Hepatology 2:433\u2013439","journal-title":"Hepatology"},{"key":"3_CR000395","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00429-005-0015-7","volume":"210","author":"K Chida","year":"2005","unstructured":"Chida K, Taguchi M (2005) Localization of alkaline phosphatase and proteins related to intercellular junctions in primary cultures of fetal rat hepatocytes. Anat Embryol (Berl) 210:75\u201380","journal-title":"Anat Embryol (Berl)"},{"key":"3_CR000396","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1267\/ahc.10037","volume":"44","author":"K Chida","year":"2011","unstructured":"Chida K, Taguchi M (2011) Localization of alkaline phosphatase and cathepsin D during cell restoration after colchicine treatment in primary cultures of fetal rat hepatocytes. Acta Histochem Cytochem 44:155\u2013158","journal-title":"Acta Histochem Cytochem"},{"key":"3_CR000397","first-page":"87","volume":"62","author":"H Ogawa","year":"1990","unstructured":"Ogawa H, Mink J, Hardison WG et\u00a0al (1990) Alkaline phosphatase activity in hepatic tissue and serum correlates with amount and type of bile acid load. Lab Invest 62:87\u201395","journal-title":"Lab Invest"},{"issue":"2","key":"3_CR000398","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.bone.2012.12.048","volume":"53","author":"C Halling Linder","year":"2013","unstructured":"Halling Linder C, Englund UH, Narisawa S et\u00a0al (2013) Isozyme profile and tissue-origin of alkaline phosphatases in mouse serum. Bone 53(2):399\u2013408","journal-title":"Bone"},{"key":"3_CR000399","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1172\/JCI106260","volume":"49","author":"MM Kaplan","year":"1970","unstructured":"Kaplan MM, Righetti A (1970) Induction of rat liver alkaline phosphatase: the mechanism of the serum elevation in bile duct obstruction. J Clin Invest 49:508\u2013516","journal-title":"J Clin Invest"},{"key":"3_CR0003100","first-page":"319","volume":"76","author":"K Poelstra","year":"1997","unstructured":"Poelstra K, Bakker WW, Klok PA et\u00a0al (1997) A physiologic function for alkaline phosphatase: endotoxin detoxification. Lab Invest 76:319\u2013327","journal-title":"Lab Invest"},{"key":"3_CR0003101","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1053\/jhep.2000.9078","volume":"32","author":"D Alvaro","year":"2000","unstructured":"Alvaro D, Benedetti A, Marucci L et\u00a0al (2000) The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat. Hepatology 32:174\u2013184","journal-title":"Hepatology"},{"key":"3_CR0003102","doi-asserted-by":"publisher","first-page":"9160","DOI":"10.1073\/pnas.91.19.9160","volume":"91","author":"F Becq","year":"1994","unstructured":"Becq F, Jensen TJ, Chang XB et\u00a0al (1994) Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc Natl Acad Sci U S A 91:9160\u20139164","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR0003103","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0014-5793(93)81016-S","volume":"327","author":"F Becq","year":"1993","unstructured":"Becq F, Fanjul M, Merten M et\u00a0al (1993) Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells. FEBS Lett 327:337\u2013342","journal-title":"FEBS Lett"},{"key":"3_CR0003104","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/00006676-199803000-00007","volume":"16","author":"Y Hori","year":"1998","unstructured":"Hori Y, Takeyama Y, Ueda T et\u00a0al (1998) Impaired transport of lipopolysaccharide across the hepatocytes in rats with cerulein-induced experimental pancreatitis. Pancreas 16:148\u2013153","journal-title":"Pancreas"},{"key":"3_CR0003105","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1128\/IAI.06109-11","volume":"80","author":"D Kanistanon","year":"2012","unstructured":"Kanistanon D, Powell DA, Hajjar AM et\u00a0al (2012) Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80:943\u2013951","journal-title":"Infect Immun"},{"key":"3_CR0003106","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","volume":"8","author":"ET Rietschel","year":"1994","unstructured":"Rietschel ET, Kirikae T, Schade FU et\u00a0al (1994) Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J 8:217\u2013225","journal-title":"FASEB J"},{"key":"3_CR0003107","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/00024382-200212000-00013","volume":"18","author":"H Bentala","year":"2002","unstructured":"Bentala H, Verweij WR, Huizinga-Van der Vlag A et\u00a0al (2002) Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide. Shock 18:561\u2013566","journal-title":"Shock"},{"key":"3_CR0003108","doi-asserted-by":"publisher","first-page":"G377","DOI":"10.1152\/ajpgi.00147.2005","volume":"290","author":"A Tuin","year":"2006","unstructured":"Tuin A, Huizinga-Van der Vlag A, van Loenen-Weemaes AM et\u00a0al (2006) On the role and fate of LPS-dephosphorylating activity in the rat liver. Am J Physiol Gastrointest Liver Physiol 290:G377\u2013G385","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3_CR0003109","first-page":"1163","volume":"151","author":"K Poelstra","year":"1997","unstructured":"Poelstra K, Bakker WW, Klok PA et\u00a0al (1997) Dephosphorylation of endotoxin by alkaline phosphatase in vivo. Am J Pathol 151:1163\u20131169","journal-title":"Am J Pathol"},{"key":"3_CR0003110","first-page":"S43","volume":"47","author":"EJ Nouwen","year":"1994","unstructured":"Nouwen EJ, De Broe ME (1994) Human intestinal versus tissue-nonspecific alkaline phosphatase as complementary urinary markers for the proximal tubule. Kidney Int Suppl 47:S43\u2013S51","journal-title":"Kidney Int Suppl"},{"key":"3_CR0003111","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0009-8981(01)00695-7","volume":"314","author":"JG March","year":"2001","unstructured":"March JG, Simonet BM, Grases F (2001) Determination of pyrophosphate in renal calculi and urine by means of an enzymatic method. Clin Chim Acta 314:187\u2013194","journal-title":"Clin Chim Acta"},{"key":"3_CR0003112","first-page":"141","volume":"53","author":"JM Baumann","year":"1977","unstructured":"Baumann JM, Bisaz S, Felix R et\u00a0al (1977) The role of inhibitors and other factors in the pathogenesis of recurrent calcium-containing renal stones. Clin Sci Mol Med 53:141\u2013148","journal-title":"Clin Sci Mol Med"},{"key":"3_CR0003113","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1159\/000186179","volume":"56","author":"NA Laminski","year":"1990","unstructured":"Laminski NA, Meyers AM, Sonnekus MI et\u00a0al (1990) Prevalence of hypocitraturia and hypopyrophosphaturia in recurrent calcium stone formers: as isolated defects or associated with other metabolic abnormalities. Nephron 56:379\u2013386","journal-title":"Nephron"},{"key":"3_CR0003114","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1073\/pnas.0712140105","volume":"105","author":"RF Goldberg","year":"2008","unstructured":"Goldberg RF, Austen WG, Zhang X et\u00a0al (2008) Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A 105:3551\u20133556","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR0003115","first-page":"435","volume":"51","author":"RG Russell","year":"1976","unstructured":"Russell RG, Bisaz S, Fleisch H (1976) The influence of orthophosphate on the renal handling of inorganic pyrophosphate in man and dog. Clin Sci Mol Med 51:435\u2013443","journal-title":"Clin Sci Mol Med"},{"key":"3_CR0003116","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0889-857X(21)00965-0","volume":"14","author":"JW Rachow","year":"1988","unstructured":"Rachow JW, Ryan LM (1988) Inorganic pyrophosphate metabolism in arthritis. Rheum Dis Clin North Am 14:289\u2013302","journal-title":"Rheum Dis Clin North Am"},{"key":"3_CR0003117","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1113\/expphysiol.2007.040790","volume":"93","author":"SH Moochhala","year":"2008","unstructured":"Moochhala SH, Sayer JA, Carr G et\u00a0al (2008) Renal calcium stones: insights from the control of bone mineralization. Exp Physiol 93:43\u201349","journal-title":"Exp Physiol"},{"key":"3_CR0003118","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1126\/science.289.5477.265","volume":"289","author":"AM Ho","year":"2000","unstructured":"Ho AM, Johnson MD, Kingsley DM (2000) Role of the mouse ank gene in control of tissue calcification and arthritis. Science 289:265\u2013270","journal-title":"Science"},{"key":"3_CR0003119","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1159\/000107534","volume":"20","author":"G Carr","year":"2007","unstructured":"Carr G, Sayer JA, Simmons NL (2007) Expression and localisation of the pyrophosphate transporter, ANK, in murine kidney cells. Cell Physiol Biochem 20:507\u2013516","journal-title":"Cell Physiol Biochem"},{"key":"3_CR0003120","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1046\/j.1365-2613.2003.00345.x","volume":"84","author":"JJ Kapojos","year":"2003","unstructured":"Kapojos JJ, Poelstra K, Borghuis T et\u00a0al (2003) Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide. Int J Exp Pathol 84:135\u2013144","journal-title":"Int J Exp Pathol"},{"key":"3_CR0003121","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.mehy.2010.09.023","volume":"76","author":"P Lencel","year":"2011","unstructured":"Lencel P, Magne D (2011) Inflammaging: the driving force in osteoporosis? Med Hypotheses 76:317\u2013321","journal-title":"Med Hypotheses"},{"key":"3_CR0003122","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.mehy.2010.07.011","volume":"75","author":"P Lencel","year":"2010","unstructured":"Lencel P, Hardouin P, Magne D (2010) Do cytokines induce vascular calcification by the mere stimulation of TNAP activity? Med Hypotheses 75:517\u2013521","journal-title":"Med Hypotheses"},{"key":"3_CR0003123","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1210\/er.2003-0015","volume":"25","author":"TM Doherty","year":"2004","unstructured":"Doherty TM, Fitzpatrick LA, Inoue D et\u00a0al (2004) Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 25:629\u2013672","journal-title":"Endocr Rev"},{"key":"3_CR0003124","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1161\/01.CIR.91.7.1959","volume":"91","author":"GS Mintz","year":"1995","unstructured":"Mintz GS, Popma JJ, Pichard AD et\u00a0al (1995) Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Circulation 91:1959\u20131965","journal-title":"Circulation"},{"key":"3_CR0003125","doi-asserted-by":"publisher","first-page":"14678","DOI":"10.1073\/pnas.0606310103","volume":"103","author":"Y Vengrenyuk","year":"2006","unstructured":"Vengrenyuk Y, Carlier S, Xanthos S et\u00a0al (2006) A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci U S A 103:14678\u201314683","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR0003126","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/01.ATV.0000059406.92165.31","volume":"23","author":"KL Tyson","year":"2003","unstructured":"Tyson KL, Reynolds JL, McNair R et\u00a0al (2003) Osteo\/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 23:489\u2013494","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3_CR0003127","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1007\/s00125-002-0920-8","volume":"45","author":"E Ishimura","year":"2002","unstructured":"Ishimura E, Okuno S, Kitatani K et\u00a0al (2002) Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients\u2013importance of glycaemic control. Diabetologia 45:1446\u20131448","journal-title":"Diabetologia"},{"key":"3_CR0003128","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1161\/01.CIR.100.21.2168","volume":"100","author":"CM Shanahan","year":"1999","unstructured":"Shanahan CM, Cary NR, Salisbury JR et\u00a0al (1999) Medial localization of mineralization-regulating proteins in association with M\u00f6nckeberg\u2019s sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 100:2168\u20132176","journal-title":"Circulation"},{"key":"3_CR0003129","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/ki.2008.26","volume":"73","author":"KA Lomashvili","year":"2008","unstructured":"Lomashvili KA, Garg P, Narisawa S et\u00a0al (2008) Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification. Kidney Int 73:1024\u20131030","journal-title":"Kidney Int"},{"key":"3_CR0003130","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1359\/jbmr.070714","volume":"22","author":"S Narisawa","year":"2007","unstructured":"Narisawa S, Harmey D, Yadav MC et\u00a0al (2007) Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification. J Bone Miner Res 22:1700\u20131710","journal-title":"J Bone Miner Res"},{"key":"3_CR0003131","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ymgme.2011.01.018","volume":"103","author":"TC Markello","year":"2011","unstructured":"Markello TC, Pak LK, St HC et\u00a0al (2011) Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab 103:44\u201350","journal-title":"Mol Genet Metab"},{"key":"3_CR0003132","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/5102","volume":"21","author":"PB Munroe","year":"1999","unstructured":"Munroe PB, Olgunturk RO, Fryns JP et\u00a0al (1999) Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Nat Genet 21:142\u2013144","journal-title":"Nat Genet"},{"key":"3_CR0003133","doi-asserted-by":"publisher","first-page":"28715","DOI":"10.1074\/jbc.M111.251462","volume":"286","author":"KA Lomashvili","year":"2011","unstructured":"Lomashvili KA, Wang X, Wallin R et\u00a0al (2011) Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification. J Biol Chem 286:28715\u201328722","journal-title":"J Biol Chem"},{"key":"3_CR0003134","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/jbmr.382","volume":"26","author":"M Leroux-Berger","year":"2011","unstructured":"Leroux-Berger M, Queguiner I, Maciel TT et\u00a0al (2011) Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin. J Bone Miner Res 26:1543\u20131553","journal-title":"J Bone Miner Res"},{"key":"3_CR0003135","doi-asserted-by":"publisher","first-page":"7290","DOI":"10.1016\/j.bmc.2009.08.048","volume":"17","author":"L Li","year":"2009","unstructured":"Li L, Chang L, Pellet-Rostaing S et\u00a0al (2009) Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases. Bioorg Med Chem 17:7290\u20137300","journal-title":"Bioorg Med Chem"},{"key":"3_CR0003136","doi-asserted-by":"publisher","first-page":"6919","DOI":"10.1021\/jm900383s","volume":"52","author":"R Dahl","year":"2009","unstructured":"Dahl R, Sergienko EA, Su Y et\u00a0al (2009) Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem 52:6919\u20136925","journal-title":"J Med Chem"},{"key":"3_CR0003137","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.arr.2007.09.001","volume":"6","author":"JJ Li","year":"2007","unstructured":"Li JJ, Zhu CG, Yu B et\u00a0al (2007) The role of inflammation in coronary artery calcification. Ageing Res Rev 6:263\u2013270","journal-title":"Ageing Res Rev"},{"key":"3_CR0003138","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1053\/ajkd.2003.50005","volume":"41","author":"T Stomp\u00f3r","year":"2003","unstructured":"Stomp\u00f3r T, Pasowicz M, Sul\u0142owicz W et\u00a0al (2003) An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis. Am J Kidney Dis 41:203\u2013211","journal-title":"Am J Kidney Dis"},{"key":"3_CR0003139","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1161\/CIRCULATIONAHA.107.732867","volume":"116","author":"E Aikawa","year":"2007","unstructured":"Aikawa E, Nahrendorf M, Figueiredo JL et\u00a0al (2007) Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 116:2841\u20132850","journal-title":"Circulation"},{"key":"3_CR0003140","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1161\/ATVBAHA.107.153668","volume":"27","author":"Z Al-Aly","year":"2007","unstructured":"Al-Aly Z, Shao JS, Lai CF et\u00a0al (2007) Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-\/- mice. Arterioscler Thromb Vasc Biol 27:2589\u20132596","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3_CR0003141","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1161\/01.CIR.102.21.2636","volume":"102","author":"Y Tintut","year":"2000","unstructured":"Tintut Y, Patel J, Parhami F et\u00a0al (2000) Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 102:2636\u20132642","journal-title":"Circulation"},{"key":"3_CR0003142","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1161\/hc0502.102969","volume":"105","author":"Y Tintut","year":"2002","unstructured":"Tintut Y, Patel J, Territo M et\u00a0al (2002) Monocyte\/macrophage regulation of vascular calcification in vitro. Circulation 105:650\u2013655","journal-title":"Circulation"},{"key":"3_CR0003143","doi-asserted-by":"publisher","first-page":"11201","DOI":"10.1073\/pnas.1932554100","volume":"100","author":"TM Doherty","year":"2003","unstructured":"Doherty TM, Asotra K, Fitzpatrick LA et\u00a0al (2003) Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A 100:11201\u201311206","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR0003144","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1042\/BST0380962","volume":"38","author":"K Iqbal","year":"2010","unstructured":"Iqbal K, Wang X, Blanchard J et\u00a0al (2010) Alzheimer\u2019s disease neurofibrillary degeneration: pivotal and multifactorial. Biochem Soc Trans 38:962\u2013966","journal-title":"Biochem Soc Trans"},{"key":"3_CR0003145","doi-asserted-by":"publisher","first-page":"32539","DOI":"10.1074\/jbc.M110.145003","volume":"285","author":"M D\u00edaz-Hern\u00e1ndez","year":"2010","unstructured":"D\u00edaz-Hern\u00e1ndez M, G\u00f3mez-Ramos A, Rubio A et\u00a0al (2010) Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. J Biol Chem 285:32539\u201332548","journal-title":"J Biol Chem"},{"key":"3_CR0003146","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000329722","volume":"9","author":"ER Vardy","year":"2012","unstructured":"Vardy ER, Kellett KA, Cocklin SL et\u00a0al (2012) Alkaline phosphatase is increased in both brain and plasma in Alzheimer\u2019s disease. Neurodegener Dis 9:31\u201337","journal-title":"Neurodegener Dis"},{"key":"3_CR0003147","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0304-4165(70)90296-5","volume":"201","author":"RM Glickman","year":"1970","unstructured":"Glickman RM, Alpers DH, Drummey GD et\u00a0al (1970) Increased lymph alkaline phosphatase after fat feeding: effects of medium chain triglycerides and inhibition of protein synthesis. Biochim Biophys Acta 201:226\u2013235","journal-title":"Biochim Biophys Acta"},{"key":"3_CR0003148","first-page":"G83","volume":"266","author":"RA Hodin","year":"1994","unstructured":"Hodin RA, Graham JR, Meng S et\u00a0al (1994) Temporal pattern of rat small intestinal gene expression with refeeding. Am J Physiol 266:G83\u2013G89","journal-title":"Am J Physiol"},{"key":"3_CR0003149","doi-asserted-by":"publisher","first-page":"7525","DOI":"10.1128\/MCB.23.21.7525-7530.2003","volume":"23","author":"S Narisawa","year":"2003","unstructured":"Narisawa S, Huang L, Iwasaki A et\u00a0al (2003) Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol 23:7525\u20137530","journal-title":"Mol Cell Biol"},{"key":"3_CR0003150","doi-asserted-by":"publisher","first-page":"G1439","DOI":"10.1152\/ajpgi.00331.2006","volume":"292","author":"T Nakano","year":"2007","unstructured":"Nakano T, Inoue I, Koyama I et\u00a0al (2007) Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis. Am J Physiol Gastrointest Liver Physiol 292:G1439\u2013G1449","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3_CR0003151","first-page":"G256","volume":"261","author":"C Pool","year":"1991","unstructured":"Pool C, Nutting DF, Simmonds WJ et\u00a0al (1991) Effect of Pluronic L81, a hydrophobic surfactant, on intestinal mucosal cholesterol homeostasis. Am J Physiol 261:G256\u2013G262","journal-title":"Am J Physiol"},{"key":"3_CR0003152","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1172\/JCI116986","volume":"93","author":"A Mahmood","year":"1994","unstructured":"Mahmood A, Yamagishi F, Eliakim R et\u00a0al (1994) A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport. J Clin Invest 93:70\u201380","journal-title":"J Clin Invest"},{"key":"3_CR0003153","doi-asserted-by":"publisher","first-page":"R1738","DOI":"10.1152\/ajpregu.00235.2011","volume":"301","author":"M Lynes","year":"2011","unstructured":"Lynes M, Narisawa S, Mill\u00e1n JL et\u00a0al (2011) Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet. Am J Physiol Regul Integr Comp Physiol 301:R1738\u2013R1747","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"3_CR0003154","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1136\/gut.2010.211706","volume":"59","author":"MS Malo","year":"2010","unstructured":"Malo MS, Alam SN, Mostafa G et\u00a0al (2010) Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut 59:1476\u20131484","journal-title":"Gut"},{"key":"3_CR0003155","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/ibd.21377","volume":"17","author":"S Ramasamy","year":"2011","unstructured":"Ramasamy S, Nguyen DD, Eston MA et\u00a0al (2011) Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis 17:532\u2013542","journal-title":"Inflamm Bowel Dis"}],"container-title":["Methods in Molecular Biology","Phosphatase Modulators"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-562-0_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T20:14:32Z","timestamp":1715717672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-562-0_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781627035613","9781627035620"],"references-count":155,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-562-0_3","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"27 June 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}