{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:41Z","timestamp":1761895841410,"version":"3.40.3"},"publisher-location":"Totowa, NJ","reference-count":32,"publisher":"Humana Press","isbn-type":[{"type":"print","value":"9781627037600"},{"type":"electronic","value":"9781627037617"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-62703-761-7_6","type":"book-chapter","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T19:24:40Z","timestamp":1392924280000},"page":"85-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Small Fragment Homologous Replacement (SFHR): Sequence-Specific Modification of Genomic DNA in Eukaryotic Cells by Small DNA Fragments"],"prefix":"10.1007","author":[{"given":"Andrea","family":"Luchetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Malgieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sangiuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"6_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/scientificamerican0394-52","volume":"270","author":"MR Capecchi","year":"1994","unstructured":"Capecchi MR (1994) Targeted gene replacement. Sci Am 270:52\u201359","journal-title":"Sci Am"},{"key":"6_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1172\/JCI200319419","volume":"112","author":"B Sullenger","year":"2003","unstructured":"Sullenger B (2003) Targeted genetic repair: an emerging approach to genetic therapy. J Clin Invest 112:310\u2013311","journal-title":"J Clin Invest"},{"key":"6_CR3","doi-asserted-by":"publisher","first-page":"9191","DOI":"10.1073\/pnas.161071798","volume":"98","author":"K Horie","year":"2001","unstructured":"Horie K, Kuroiwa A, Ikawa M, Okabe M, Kondoh G, Matsuda Y, Takeda J (2001) Efficient chromosomal transposition of a Tc1\/mariner-like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A 98:9191\u20139196","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"6_CR4","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0092-8674(00)80436-5","volume":"91","author":"Z Ivics","year":"1997","unstructured":"Ivics Z, Plasterk RH, Izsvak Z (1997) Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91(4):501\u2013510","journal-title":"Cell"},{"issue":"2","key":"6_CR5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ymthe.2003.11.009","volume":"9","author":"Z Izsvak","year":"2003","unstructured":"Izsvak Z (2003) Sleeping beauty transposition: biology and applications for molecular therapy. Mol Ther 9(2):147\u2013156","journal-title":"Mol Ther"},{"key":"6_CR6","first-page":"2017","volume":"93","author":"K Yoon","year":"1996","unstructured":"Yoon K, Cole-Strauss A, Kmiec EB (1996) Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA-DNA oligonucleotide. Proc Natl Acad Sci U S A 93:2017\u20132076","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/75435","volume":"18","author":"T Zhu","year":"2000","unstructured":"Zhu T, Mettenburg K, Peterson DJ, Tagliani L, Baszczynski CL (2000) Engineering herbicide-resistant maize using chimeric RNA\/DNA oligonucleotides. Nat Biotechnol 18:555\u2013558","journal-title":"Nat Biotechnol"},{"issue":"10","key":"6_CR8","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nrg908","volume":"3","author":"MT McManus","year":"2002","unstructured":"McManus MT, Sharp PA (2002) Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 3(10):737\u2013747","journal-title":"Nat Rev Genet"},{"issue":"7042","key":"6_CR9","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nature03556","volume":"435","author":"FD Urnov","year":"2005","unstructured":"Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, Jamieson AC, Porteus MH, Gregory PD, Holmes MC (2005) Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435(7042):646\u2013651","journal-title":"Nature"},{"key":"6_CR10","first-page":"607","volume":"1","author":"DC Gruenert","year":"1998","unstructured":"Gruenert DC (1998) Gene correction with small DNA fragments. Curr Res Mol Therapeut 1:607\u2013613","journal-title":"Curr Res Mol Therapeut"},{"key":"6_CR11","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1038\/sj.gt.3301011","volume":"6","author":"DC Gruenert","year":"1999","unstructured":"Gruenert DC (1999) Opportunities and challenges in targeting genes for therapy. Gene Ther 6:1347\u20131348","journal-title":"Gene Ther"},{"issue":"2","key":"6_CR12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/sj.gt.3300601","volume":"5","author":"RJ Y\u00e1\u00f1ez","year":"1998","unstructured":"Y\u00e1\u00f1ez RJ, Porter AC (1998) Therapeutic gene targeting. Gene Ther 5(2):149\u2013159","journal-title":"Gene Ther"},{"key":"6_CR13","first-page":"85","volume":"133","author":"KK Goncz","year":"2000","unstructured":"Goncz KK, Gruenert DC (2000) Site-directed alteration of genomic DNA by small-fragment homologous replacement. Methods Mol Biol 133:85\u201399","journal-title":"Methods Mol Biol"},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/sj.gt.3301743","volume":"9","author":"BR Davis","year":"2002","unstructured":"Davis BR, Gruenert DC (2002) Application of SFHR to gene therapy of monogenic disorders. Gene Ther 9:691\u2013694","journal-title":"Gene Ther"},{"key":"6_CR15","first-page":"859","volume":"3","author":"K Kunzelmann","year":"1996","unstructured":"Kunzelmann K, Legendre JY, Knoell DL, Escobar LC, Xu Z, Gruenert DC (1996) Gene targeting of CFTR DNA in CF epithelial cells. Gene Ther 3:859\u2013867","journal-title":"Gene Ther"},{"key":"6_CR16","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1006\/mthe.2000.0242","volume":"3","author":"A Colosimo","year":"2001","unstructured":"Colosimo A, Goncz KK, Novelli G, Dallapiccola B, Gruenert DC (2001) Targeted correction of a defective selectable marker gene in human epithelial cells by small DNA fragments. Mol Ther 3:178\u2013185","journal-title":"Mol Ther"},{"key":"6_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2350-3-8","volume":"3","author":"F Sangiuolo","year":"2002","unstructured":"Sangiuolo F, Bruscia E, Serafino A, Nardone AM, Bonifazi E, Lais M, Gruenert DC, Novelli G (2002) In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique. BMC Med Genet 3:8","journal-title":"BMC Med Genet"},{"key":"6_CR18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1196\/annals.1348.063","volume":"1082","author":"R Maurisse","year":"2006","unstructured":"Maurisse R, Cheung J, Widdicombe J, Gruenert DC (2006) Modification of the pig CFTR gene mediated by small fragment homologous replacement. Ann N Y Acad Sci 1082:120\u2013123","journal-title":"Ann N Y Acad Sci"},{"key":"6_CR19","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.2741\/2904","volume":"1","author":"F Sangiuolo","year":"2008","unstructured":"Sangiuolo F, Scaldaferri ML, Filareto A, Spitalieri P, Guerra L et al (2008) Cftr gene targeting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR). Front Biosci 1:2989\u20132999","journal-title":"Front Biosci"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1089\/104303401300057324","volume":"12","author":"A Quigley","year":"2001","unstructured":"Quigley A, Lynch GS, Steeper K, Kornberg AJ, Gregorevic P, Austin L, Byrne E (2001) In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement. Hum Gene Ther 12:629\u2013642","journal-title":"Hum Gene Ther"},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/humu.20494","volume":"28","author":"M Todaro","year":"2007","unstructured":"Todaro M, Quigley A, Kita M, Chin J, Lowes K, Kornberg AJ, Cook MJ, Kapsa R (2007) Effective detection of corrected dystrophin loci in mdx mouse myogenic precursors. Hum Mutat 28:816\u2013823","journal-title":"Hum Mutat"},{"key":"6_CR22","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1089\/hum.2005.16.869","volume":"16","author":"F Sangiuolo","year":"2005","unstructured":"Sangiuolo F, Filareto A, Spitalieri P, Scaldaferri ML, Mango R et al (2005) In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement. Hum Gene Ther 16:869\u2013880","journal-title":"Hum Gene Ther"},{"key":"6_CR23","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1089\/clo.2009.0046","volume":"11","author":"P Spitalieri","year":"2009","unstructured":"Spitalieri P, Cortese G, Pietropolli A, Filareto A, Dolci S et al (2009) Identification of multipotent cytotrophoblast cells from human first trimester chorionic villi. Cloning Stem Cells 11:535\u2013546","journal-title":"Cloning Stem Cells"},{"key":"6_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1089\/hum.2006.17.158","volume":"17","author":"H Zayed","year":"2006","unstructured":"Zayed H, McIvor RS, Wiest DL, Blazar BR (2006) In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement. Hum Gene Ther 17:158\u2013166","journal-title":"Hum Gene Ther"},{"key":"6_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1089\/oli.2006.16.213","volume":"16","author":"KK Goncz","year":"2006","unstructured":"Goncz KK, Prokopishyn NL, Abdolmohammadi A, Bedayat B, Maurisse R, Davis BR, Gruenert DC (2006) Small fragment homologous replacement-mediated modification of genomic beta-globin sequences in human hematopoietic stem\/progenitor cells. Oligonucleotides 16:213\u2013224","journal-title":"Oligonucleotides"},{"key":"6_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1089\/oli.2009.0205","volume":"20","author":"B Bedayat","year":"2009","unstructured":"Bedayat B, Abdolmohamadi A, Ye L, Maurisse R, Parsi H et al (2009) Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement. Oligonucleotides 20:7\u201316","journal-title":"Oligonucleotides"},{"key":"6_CR27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1385\/MB:29:3:197","volume":"29","author":"Y Hu","year":"2005","unstructured":"Hu Y, Parekh-Olmedo H, Drury M, Skogen M, Kmiec EB (2005) Reaction parameters of targeted gene repair in mammalian cells. Mol Biotechnol 29:197\u2013210","journal-title":"Mol Biotechnol"},{"key":"6_CR28","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.4161\/cc.7.10.5826","volume":"7","author":"JU Engstrom","year":"2008","unstructured":"Engstrom JU, Kmiec EB (2008) DNA replication, cell cycle progression and the targeted gene repair reaction. Cell Cycle 7:1402\u20131414","journal-title":"Cell Cycle"},{"key":"6_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.dnarep.2004.11.007","volume":"4","author":"EE Brachman","year":"2005","unstructured":"Brachman EE, Kmiec EB (2005) Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks. DNA Repair 4:445\u2013457","journal-title":"DNA Repair"},{"key":"6_CR30","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1172\/JCI19773","volume":"112","author":"DC Gruenert","year":"2003","unstructured":"Gruenert DC, Bruscia E, Novelli G, Colosimo A, Dallapiccola B et al (2003) Sequence-specific modification of genomic DNA by small DNA fragments. J Clin Invest 112:637\u2013641","journal-title":"J Clin Invest"},{"issue":"2","key":"6_CR31","doi-asserted-by":"publisher","first-page":"e30851","DOI":"10.1371\/journal.pone.0030851","volume":"7","author":"A Luchetti","year":"2012","unstructured":"Luchetti A, Filareto A, Sanchez M, Ferraguti G, Lucarelli M, Novelli G, Sangiuolo F, Malgieri A (2012) Small fragment homologous replacement: evaluation of factors influencing modification efficiency in an eukaryotic assay system. PLoS One 7(2):e30851","journal-title":"PLoS One"},{"key":"6_CR32","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1089\/oli.2006.16.375","volume":"16","author":"R Maurisse","year":"2006","unstructured":"Maurisse R, Fichou Y, De Semir D, Cheung J, Ferec C, Gruenert DC (2006) Gel purification of genomic DNA removes contaminating small DNA fragments interfering with PCR analysis of SFHR. Oligonucleotides 16:375\u2013386","journal-title":"Oligonucleotides"}],"container-title":["Methods in Molecular Biology","Gene Correction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-62703-761-7_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T23:01:47Z","timestamp":1675983707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-62703-761-7_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9781627037600","9781627037617"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-1-62703-761-7_6","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"1 February 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}