{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:31:06Z","timestamp":1792618266832,"version":"4.5.0"},"publisher-location":"Cham","reference-count":106,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030026004","type":"print"},{"value":"9783030026011","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-030-02601-1_2","type":"book-chapter","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T10:48:12Z","timestamp":1544093292000},"page":"5-19","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["The NG2 Proteoglycan in Pericyte Biology"],"prefix":"10.1007","author":[{"given":"William B.","family":"Stallcup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"14361","DOI":"10.1038\/ncomms14361","volume":"8","author":"E Dejana","year":"2017","unstructured":"Dejana E, Hirschi KK, Simons M (2017) The molecular basis of endothelial cell plasticity. Nat Commun 8:14361","journal-title":"Nat Commun"},{"issue":"1","key":"2_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1152\/physrev.00001.2017","volume":"98","author":"G Eelen","year":"2018","unstructured":"Eelen G et al (2018) Endothelial cell metabolism. Physiol Rev 98(1):3\u201358","journal-title":"Physiol Rev"},{"issue":"6","key":"2_CR3","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.devcel.2017.06.008","volume":"41","author":"CA Franco","year":"2017","unstructured":"Franco CA, Gerhardt H (2017) Morph or move? How distinct endothelial cell responses to blood flow shape vascular networks. Dev Cell 41(6):574\u2013576","journal-title":"Dev Cell"},{"issue":"6626","key":"2_CR4","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/386671a0","volume":"386","author":"W Risau","year":"1997","unstructured":"Risau W (1997) Mechanisms of angiogenesis. Nature 386(6626):671\u2013674","journal-title":"Nature"},{"issue":"24","key":"2_CR5","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1007\/s00018-017-2577-y","volume":"74","author":"EC Watson","year":"2017","unstructured":"Watson EC, Grant ZL, Coultas L (2017) Endothelial cell apoptosis in angiogenesis and vessel regression. Cell Mol Life Sci 74(24):4387\u20134403","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"2_CR6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","volume":"97","author":"A Armulik","year":"2005","unstructured":"Armulik A, Abramsson A, Betsholtz C (2005) Endothelial\/pericyte interactions. Circ Res 97(6):512\u2013523","journal-title":"Circ Res"},{"issue":"1","key":"2_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00441-003-0745-x","volume":"314","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Betsholtz C (2003) Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 314(1):15\u201323","journal-title":"Cell Tissue Res"},{"issue":"11","key":"2_CR8","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1161\/01.RES.0000191547.64391.e3","volume":"97","author":"GE Davis","year":"2005","unstructured":"Davis GE, Senger DR (2005) Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res 97(11):1093\u20131107","journal-title":"Circ Res"},{"issue":"6","key":"2_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/nrc1094","volume":"3","author":"R Kalluri","year":"2003","unstructured":"Kalluri R (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3(6):422\u2013433","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2_CR10","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00041.2008","volume":"89","author":"JE Wagenseil","year":"2009","unstructured":"Wagenseil JE, Mecham RP (2009) Vascular extracellular matrix and arterial mechanics. Physiol Rev 89(3):957\u2013989","journal-title":"Physiol Rev"},{"issue":"3","key":"2_CR11","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.ajpath.2011.11.006","volume":"180","author":"WK You","year":"2012","unstructured":"You WK, Bonaldo P, Stallcup WB (2012) Collagen VI ablation retards brain tumor progression due to deficits in assembly of the vascular basal lamina. Am J Pathol 180(3):1145\u20131158","journal-title":"Am J Pathol"},{"key":"2_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/B978-0-12-801419-6.00012-4","volume-title":"Brain metastases from primary tumors","author":"WK You","year":"2015","unstructured":"You WK, Stallcup WB (2015) Melanoma progression in the brain: role of pericytes, the basal lamina, and endothelial cells in tumor vascularization. In: Hayat MA (ed) Brain metastases from primary tumors, 1st edn. Academic, New York, pp 133\u2013143","edition":"1"},{"issue":"1","key":"2_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000047855","volume":"169","author":"G Allt","year":"2001","unstructured":"Allt G, Lawrenson JG (2001) Pericytes: cell biology and pathology. Cells Tissues Organs 169(1):1\u201311","journal-title":"Cells Tissues Organs"},{"issue":"4","key":"2_CR14","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1215\/S1152851705000232","volume":"7","author":"G Bergers","year":"2005","unstructured":"Bergers G, Song S (2005) The role of pericytes in blood-vessel formation and maintenance. Neuro-Oncology 7(4):452\u2013464","journal-title":"Neuro-Oncology"},{"key":"2_CR15","first-page":"115","volume":"94","author":"C Betsholtz","year":"2005","unstructured":"Betsholtz C, Lindblom P, Gerhardt H (2005) Role of pericytes in vascular morphogenesis. EXS 94:115\u2013125","journal-title":"EXS"},{"issue":"10","key":"2_CR16","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1046\/j.1440-1681.2000.03343.x","volume":"27","author":"DE Sims","year":"2000","unstructured":"Sims DE (2000) Diversity within pericytes. Clin Exp Pharmacol Physiol 27(10):842\u2013846","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"2_CR17","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3390\/ijms18061129","volume":"18","author":"H Thomas","year":"2017","unstructured":"Thomas H, Cowin AJ, Mills SJ (2017) The importance of pericytes in healing: wounds and other pathologies. Int J Mol Sci 18(6):1129","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s12035-013-8610-8","volume":"50","author":"F Biname","year":"2014","unstructured":"Biname F (2014) Transduction of extracellular cues into cell polarity: the role of the transmembrane proteoglycan NG2. Mol Neurobiol 50(2):482\u2013493","journal-title":"Mol Neurobiol"},{"issue":"Pt B","key":"2_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.brainres.2015.06.003","volume":"1638","author":"D Sakry","year":"2016","unstructured":"Sakry D, Trotter J (2016) The role of the NG2 proteoglycan in OPC and CNS network function. Brain Res 1638(Pt B):161\u2013166","journal-title":"Brain Res"},{"issue":"6\u20137","key":"2_CR20","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1023\/A:1025731428581","volume":"31","author":"WB Stallcup","year":"2002","unstructured":"Stallcup WB (2002) The NG2 proteoglycan: past insights and future prospects. J Neurocytol 31(6\u20137):423\u2013435","journal-title":"J Neurocytol"},{"issue":"3","key":"2_CR21","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4161\/cam.2.3.6279","volume":"2","author":"WB Stallcup","year":"2008","unstructured":"Stallcup WB, Huang FJ (2008) A role for the NG2 proteoglycan in glioma progression. Cell Adhes Migr 2(3):192\u2013201","journal-title":"Cell Adhes Migr"},{"issue":"1","key":"2_CR22","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1006\/excr.1995.1371","volume":"221","author":"KA Grako","year":"1995","unstructured":"Grako KA, Stallcup WB (1995) Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to platelet-derived growth factor. Exp Cell Res 221(1):231\u2013240","journal-title":"Exp Cell Res"},{"issue":"18","key":"2_CR23","first-page":"4986","volume":"51","author":"M Schrappe","year":"1991","unstructured":"Schrappe M et al (1991) Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells. Cancer Res 51(18):4986\u20134993","journal-title":"Cancer Res"},{"issue":"5","key":"2_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1096\/fasebj.11.5.9141503","volume":"11","author":"L Beck Jr","year":"1997","unstructured":"Beck L Jr, D\u2019Amore PA (1997) Vascular development: cellular and molecular regulation. FASEB J 11(5):365\u2013373","journal-title":"FASEB J"},{"issue":"3","key":"2_CR25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1161\/01.RES.84.3.298","volume":"84","author":"KK Hirschi","year":"1999","unstructured":"Hirschi KK et al (1999) Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res 84(3):298\u2013305","journal-title":"Circ Res"},{"issue":"3","key":"2_CR26","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1083\/jcb.105.3.1455","volume":"105","author":"A Orlidge","year":"1987","unstructured":"Orlidge A, D'Amore PA (1987) Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J Cell Biol 105(3):1455\u20131462","journal-title":"J Cell Biol"},{"issue":"1","key":"2_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1083\/jcb.109.1.309","volume":"109","author":"Y Sato","year":"1989","unstructured":"Sato Y, Rifkin DB (1989) Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol 109(1):309\u2013315","journal-title":"J Cell Biol"},{"issue":"3","key":"2_CR28","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1084\/jem.167.3.1003","volume":"167","author":"RC Nayak","year":"1988","unstructured":"Nayak RC et al (1988) A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes. J Exp Med 167(3):1003\u20131015","journal-title":"J Exp Med"},{"issue":"4","key":"2_CR29","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/(SICI)1096-9896(199608)179:4<436::AID-PATH611>3.0.CO;2-A","volume":"179","author":"RO Schlingemann","year":"1996","unstructured":"Schlingemann RO et al (1996) Aminopeptidase a is a constituent of activated pericytes in angiogenesis. J Pathol 179(4):436\u2013442","journal-title":"J Pathol"},{"issue":"1","key":"2_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00041552-199801000-00004","volume":"7","author":"P Lindahl","year":"1998","unstructured":"Lindahl P, Betsholtz C (1998) Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice. Curr Opin Nephrol Hypertens 7(1):21\u201326","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"5323","key":"2_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.277.5323.242","volume":"277","author":"P Lindahl","year":"1997","unstructured":"Lindahl P et al (1997) Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277(5323):242\u2013245","journal-title":"Science"},{"issue":"9","key":"2_CR32","doi-asserted-by":"publisher","first-page":"870\u20139","DOI":"10.1038\/ncb1288","volume":"7","author":"S Song","year":"2005","unstructured":"Song S et al (2005) PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 7(9):870\u20139","journal-title":"Nat Cell Biol"},{"issue":"2","key":"2_CR33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/dvdy.1200","volume":"222","author":"U Ozerdem","year":"2001","unstructured":"Ozerdem U et al (2001) NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev Dyn 222(2):218\u2013227","journal-title":"Dev Dyn"},{"issue":"1","key":"2_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1006\/mvre.2001.2376","volume":"63","author":"U Ozerdem","year":"2002","unstructured":"Ozerdem U, Monosov E, Stallcup WB (2002) NG2 proteoglycan expression by pericytes in pathological microvasculature. Microvasc Res 63(1):129\u2013134","journal-title":"Microvasc Res"},{"issue":"3","key":"2_CR35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1023\/B:AGEN.0000021401.58039.a9","volume":"6","author":"U Ozerdem","year":"2003","unstructured":"Ozerdem U, Stallcup WB (2003) Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis 6(3):241\u2013249","journal-title":"Angiogenesis"},{"issue":"3","key":"2_CR36","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1242\/dev.002071","volume":"135","author":"U Tigges","year":"2008","unstructured":"Tigges U et al (2008) FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages. Development 135(3):523\u2013532","journal-title":"Development"},{"issue":"1","key":"2_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10456-006-9061-x","volume":"10","author":"D Virgintino","year":"2007","unstructured":"Virgintino D et al (2007) An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis. Angiogenesis 10(1):35\u201345","journal-title":"Angiogenesis"},{"issue":"14","key":"2_CR38","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1242\/dev.126.14.3047","volume":"126","author":"M Hellstrom","year":"1999","unstructured":"Hellstrom M et al (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126(14):3047\u20133055","journal-title":"Development"},{"issue":"2","key":"2_CR39","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1186\/bcr3174","volume":"14","author":"K Gibby","year":"2012","unstructured":"Gibby K et al (2012) Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the neuron-glial antigen 2 proteoglycan. Breast Cancer Res 14(2):R67","journal-title":"Breast Cancer Res"},{"issue":"2","key":"2_CR40","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.ydbio.2010.06.023","volume":"344","author":"FJ Huang","year":"2010","unstructured":"Huang FJ et al (2010) Pericyte deficiencies lead to aberrant tumor vascularization in the brain of the NG2 null mouse. Dev Biol 344(2):1035\u20131046","journal-title":"Dev Biol"},{"issue":"1","key":"2_CR41","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10456-013-9378-1","volume":"17","author":"WK You","year":"2014","unstructured":"You WK et al (2014) NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function. Angiogenesis 17(1):61\u201376","journal-title":"Angiogenesis"},{"issue":"1","key":"2_CR42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/dvdy.10359","volume":"228","author":"J Fukushi","year":"2003","unstructured":"Fukushi J et\u00a0al (2003) Expression of NG2 proteoglycan during endochondral and intramembranous ossification. Dev Dyn 228(1):143\u2013148","journal-title":"Dev Dyn"},{"issue":"3","key":"2_CR43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1369\/jhc.7A7349.2007","volume":"56","author":"K Kadoya","year":"2008","unstructured":"Kadoya K et al (2008) NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouse. J Histochem Cytochem 56(3):295\u2013303","journal-title":"J Histochem Cytochem"},{"issue":"11","key":"2_CR44","doi-asserted-by":"publisher","first-page":"e0187530","DOI":"10.1371\/journal.pone.0187530","volume":"12","author":"K Kucharova","year":"2017","unstructured":"Kucharova K, Stallcup WB (2017) Distinct NG2 proteoglycan-dependent roles of resident microglia and bone marrow-derived macrophages during myelin damage and repair. PLoS One 12(11):e0187530","journal-title":"PLoS One"},{"issue":"3","key":"2_CR45","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<299::AID-JNR5>3.0.CO;2-E","volume":"43","author":"A Nishiyama","year":"1996","unstructured":"Nishiyama A et al (1996) Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res 43(3):299\u2013314","journal-title":"J Neurosci Res"},{"issue":"4","key":"2_CR46","doi-asserted-by":"publisher","first-page":"e1001204","DOI":"10.1080\/2162402X.2014.1001204","volume":"4","author":"F Yotsumoto","year":"2015","unstructured":"Yotsumoto F et al (2015) NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization. Oncoimmunology 4(4):e1001204","journal-title":"Oncoimmunology"},{"issue":"1","key":"2_CR47","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12974-015-0385-6","volume":"12","author":"K Kucharova","year":"2015","unstructured":"Kucharova K, Stallcup WB (2015) NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair. J Neuroinflammation 12(1):161","journal-title":"J Neuroinflammation"},{"issue":"11","key":"2_CR48","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1242\/dev.01846","volume":"132","author":"B Brachvogel","year":"2005","unstructured":"Brachvogel B et al (2005) Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages. Development 132(11):2657\u20132668","journal-title":"Development"},{"issue":"3","key":"2_CR49","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.stem.2008.08.008","volume":"3","author":"AI Caplan","year":"2008","unstructured":"Caplan AI (2008) All MSCs are pericytes? Cell Stem Cell 3(3):229\u2013230","journal-title":"Cell Stem Cell"},{"issue":"3","key":"2_CR50","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","volume":"3","author":"M Crisan","year":"2008","unstructured":"Crisan M et al (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301\u2013313","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2_CR51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1161\/CIRCRESAHA.107.159475","volume":"102","author":"DO Traktuev","year":"2008","unstructured":"Traktuev DO et al (2008) A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res 102(1):77\u201385","journal-title":"Circ Res"},{"issue":"1","key":"2_CR52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1161\/ATVBAHA.115.306074","volume":"36","author":"ZG She","year":"2016","unstructured":"She ZG et al (2016) NG2 proteoglycan ablation reduces foam cell formation and atherogenesis via decreased low-density lipoprotein retention by synthetic smooth muscle cells. Arterioscler Thromb Vasc Biol 36(1):49\u201359","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"2_CR53","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000345524","volume":"50","author":"U Tigges","year":"2013","unstructured":"Tigges U, Komatsu M, Stallcup WB (2013) Adventitial pericyte progenitor\/mesenchymal stem cells participate in the restenotic response to arterial injury. J Vasc Res 50(2):134\u2013144","journal-title":"J Vasc Res"},{"issue":"2","key":"2_CR54","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/10739680590904955","volume":"12","author":"WL Murfee","year":"2005","unstructured":"Murfee WL, Skalak TC, Peirce SM (2005) Differential arterial\/venous expression of NG2 proteoglycan in perivascular cells along microvessels: identifying a venule-specific phenotype. Microcirculation 12(2):151\u2013160","journal-title":"Microcirculation"},{"issue":"3","key":"2_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/10739680600559153","volume":"13","author":"WL Murfee","year":"2006","unstructured":"Murfee WL et al (2006) Perivascular cells along venules upregulate NG2 expression during microvascular remodeling. Microcirculation 13(3):261\u2013273","journal-title":"Microcirculation"},{"issue":"10","key":"2_CR56","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1091\/mbc.10.10.3373","volume":"10","author":"X Fang","year":"1999","unstructured":"Fang X et al (1999) Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration. Mol Biol Cell 10(10):3373\u20133387","journal-title":"Mol Biol Cell"},{"issue":"4","key":"2_CR57","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/(SICI)1097-4644(19961215)63:4<463::AID-JCB8>3.0.CO;2-R","volume":"63","author":"XH Lin","year":"1996","unstructured":"Lin XH, Dahlin-Huppe K, Stallcup WB (1996) Interaction of the NG2 proteoglycan with the actin cytoskeleton. J Cell Biochem 63(4):463\u2013477","journal-title":"J Cell Biochem"},{"issue":"12","key":"2_CR58","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1091\/mbc.7.12.1977","volume":"7","author":"XH Lin","year":"1996","unstructured":"Lin XH et al (1996) NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. Mol Biol Cell 7(12):1977\u20131993","journal-title":"Mol Biol Cell"},{"issue":"1","key":"2_CR59","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0898-6568(02)00045-1","volume":"15","author":"M Majumdar","year":"2003","unstructured":"Majumdar M, Vuori K, Stallcup WB (2003) Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Cell Signal 15(1):79\u201384","journal-title":"Cell Signal"},{"issue":"12","key":"2_CR60","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/nrm1257","volume":"4","author":"JR Couchman","year":"2003","unstructured":"Couchman JR (2003) Syndecans: proteoglycan regulators of cell-surface microdomains? Nat Rev Mol Cell Biol 4(12):926\u2013937","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"2_CR61","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10456-012-9316-7","volume":"16","author":"S Cattaruzza","year":"2013","unstructured":"Cattaruzza S et al (2013) Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells. Angiogenesis 16(2):309\u2013327","journal-title":"Angiogenesis"},{"issue":"24","key":"2_CR62","doi-asserted-by":"publisher","first-page":"16831","DOI":"10.1074\/jbc.274.24.16831","volume":"274","author":"L Goretzki","year":"1999","unstructured":"Goretzki L et al (1999) High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. J Biol Chem 274(24):16831\u201316837","journal-title":"J Biol Chem"},{"issue":"10","key":"2_CR63","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/1074-5521(95)90025-X","volume":"2","author":"AC Rapraeger","year":"1995","unstructured":"Rapraeger AC (1995) In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding? Chem Biol 2(10):645\u2013649","journal-title":"Chem Biol"},{"issue":"Pt 6","key":"2_CR64","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1242\/jcs.112.6.905","volume":"112","author":"KA Grako","year":"1999","unstructured":"Grako KA et al (1999) PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci 112(Pt 6):905\u2013915","journal-title":"J Cell Sci"},{"issue":"3","key":"2_CR65","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<315::AID-JNR6>3.0.CO;2-M","volume":"43","author":"A Nishiyama","year":"1996","unstructured":"Nishiyama A et al (1996) Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF. J Neurosci Res 43(3):315\u2013330","journal-title":"J Neurosci Res"},{"issue":"39","key":"2_CR66","doi-asserted-by":"publisher","first-page":"5182","DOI":"10.1038\/onc.2008.157","volume":"27","author":"M Chekenya","year":"2008","unstructured":"Chekenya M et al (2008) The progenitor cell marker NG2\/MPG promotes chemoresistance by activation of integrin-dependent PI3K\/Akt signaling. Oncogene 27(39):5182\u20135194","journal-title":"Oncogene"},{"issue":"8","key":"2_CR67","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1091\/mbc.e04-03-0236","volume":"15","author":"J Fukushi","year":"2004","unstructured":"Fukushi J, Makagiansar IT, Stallcup WB (2004) NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell 15(8):3580\u20133590","journal-title":"Mol Biol Cell"},{"key":"2_CR68","doi-asserted-by":"crossref","unstructured":"Stallcup WB (2017) NG2 proteoglycan enhances brain tumor progression by promoting beta-1 integrin activation in both cis and trans orientations. Cancers (Basel) 9(4) E31","DOI":"10.3390\/cancers9040031"},{"issue":"53","key":"2_CR69","doi-asserted-by":"publisher","first-page":"55262","DOI":"10.1074\/jbc.M411045200","volume":"279","author":"IT Makagiansar","year":"2004","unstructured":"Makagiansar IT et al (2004) Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. J Biol Chem 279(53):55262\u201355270","journal-title":"J Biol Chem"},{"issue":"1","key":"2_CR70","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.200612084","volume":"178","author":"IT Makagiansar","year":"2007","unstructured":"Makagiansar IT et al (2007) Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration. J Cell Biol 178(1):155\u2013165","journal-title":"J Cell Biol"},{"issue":"2","key":"2_CR71","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G","volume":"79","author":"DS Barritt","year":"2000","unstructured":"Barritt DS et al (2000) The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem 79(2):213\u2013224","journal-title":"J Cell Biochem"},{"issue":"13","key":"2_CR72","doi-asserted-by":"publisher","first-page":"8310","DOI":"10.1074\/jbc.M706074200","volume":"283","author":"N Chatterjee","year":"2008","unstructured":"Chatterjee N et al (2008) Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells. J Biol Chem 283(13):8310\u20138317","journal-title":"J Biol Chem"},{"issue":"6","key":"2_CR73","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1074\/jbc.M210010200","volume":"278","author":"J Stegmuller","year":"2003","unstructured":"Stegmuller J et\u00a0al (2003) The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. J Biol Chem 278(6):3590\u20133598","journal-title":"J Biol Chem"},{"issue":"3","key":"2_CR74","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10456-004-4182-6","volume":"7","author":"U Ozerdem","year":"2004","unstructured":"Ozerdem U, Stallcup WB (2004) Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan. Angiogenesis 7(3):269\u2013276","journal-title":"Angiogenesis"},{"issue":"19","key":"2_CR75","doi-asserted-by":"publisher","first-page":"11067","DOI":"10.1074\/jbc.271.19.11067","volume":"271","author":"A Luque","year":"1996","unstructured":"Luque A et al (1996) Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355\u2013425) of the common beta 1 chain. J Biol Chem 271(19):11067\u201311075","journal-title":"J Biol Chem"},{"issue":"16","key":"2_CR76","doi-asserted-by":"publisher","first-page":"10769","DOI":"10.1074\/jbc.272.16.10769","volume":"272","author":"E Tillet","year":"1997","unstructured":"Tillet E et al (1997) The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. J Biol Chem 272(16):10769\u201310776","journal-title":"J Biol Chem"},{"issue":"19","key":"2_CR77","doi-asserted-by":"publisher","first-page":"9051","DOI":"10.1073\/pnas.90.19.9051","volume":"90","author":"M Lenter","year":"1993","unstructured":"Lenter M et al (1993) A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc Natl Acad Sci U S A 90(19):9051\u20139055","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2_CR78","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1016\/S0002-9440(10)63568-7","volume":"163","author":"EY Lin","year":"2003","unstructured":"Lin EY et al (2003) Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163(5):2113\u20132126","journal-title":"Am J Pathol"},{"issue":"22","key":"2_CR79","first-page":"8298","volume":"61","author":"JE Maglione","year":"2001","unstructured":"Maglione JE et al (2001) Transgenic Polyoma middle-T mice model premalignant mammary disease. Cancer Res 61(22):8298\u20138305","journal-title":"Cancer Res"},{"issue":"118","key":"2_CR80","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/newbio242148a0","volume":"242","author":"IJ Fidler","year":"1973","unstructured":"Fidler IJ (1973) Selection of successive tumour lines for metastasis. Nat New Biol 242(118):148\u2013149","journal-title":"Nat New Biol"},{"issue":"6","key":"2_CR81","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrc1093","volume":"3","author":"G Bergers","year":"2003","unstructured":"Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3(6):401\u2013410","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2_CR82","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","volume":"86","author":"D Hanahan","year":"1996","unstructured":"Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86(3):353\u2013364","journal-title":"Cell"},{"issue":"6219","key":"2_CR83","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/339058a0","volume":"339","author":"J Folkman","year":"1989","unstructured":"Folkman J et\u00a0al (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339(6219):58\u201361","journal-title":"Nature"},{"issue":"3","key":"2_CR84","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.neuroimage.2005.08.026","volume":"29","author":"C Brekke","year":"2006","unstructured":"Brekke C et al (2006) NG2 expression regulates vascular morphology and function in human brain tumours. NeuroImage 29(3):965\u2013976","journal-title":"NeuroImage"},{"issue":"19","key":"2_CR85","doi-asserted-by":"publisher","first-page":"8066","DOI":"10.1158\/0008-5472.CAN-08-0287","volume":"68","author":"PC Maciag","year":"2008","unstructured":"Maciag PC et al (2008) Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature. Cancer Res 68(19):8066\u20138075","journal-title":"Cancer Res"},{"issue":"7","key":"2_CR86","doi-asserted-by":"publisher","first-page":"e23062","DOI":"10.1371\/journal.pone.0023062","volume":"6","author":"J Wang","year":"2011","unstructured":"Wang J et\u00a0al (2011) Targeting the NG2\/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma. PLoS One 6(7):e23062","journal-title":"PLoS One"},{"issue":"1","key":"2_CR87","first-page":"11","volume":"1796","author":"SB Coffelt","year":"2009","unstructured":"Coffelt SB, Hughes R, Lewis CE (2009) Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta 1796(1):11\u201318","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2_CR88","first-page":"5","volume":"1796","author":"M Palma De","year":"2009","unstructured":"De Palma M, Naldini L (2009) Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy? Biochim Biophys Acta 1796(1):5\u201310","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"2_CR89","doi-asserted-by":"publisher","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","volume":"66","author":"EY Lin","year":"2006","unstructured":"Lin EY et al (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66(23):11238\u201311246","journal-title":"Cancer Res"},{"issue":"1","key":"2_CR90","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","volume":"41","author":"R Noy","year":"2014","unstructured":"Noy R, Pollard JW (2014) Tumor-associated macrophages: from mechanisms to therapy. Immunity 41(1):49\u201361","journal-title":"Immunity"},{"issue":"1","key":"2_CR91","doi-asserted-by":"publisher","first-page":"e30637","DOI":"10.1371\/journal.pone.0030637","volume":"7","author":"Y Chang","year":"2012","unstructured":"Chang Y et al (2012) Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. PLoS One 7(1):e30637","journal-title":"PLoS One"},{"issue":"1","key":"2_CR92","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.cell.2005.10.034","volume":"124","author":"SS Foo","year":"2006","unstructured":"Foo SS et al (2006) Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124(1):161\u2013173","journal-title":"Cell"},{"issue":"7223","key":"2_CR93","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nature07445","volume":"456","author":"C Stockmann","year":"2008","unstructured":"Stockmann C et al (2008) Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456(7223):814\u2013818","journal-title":"Nature"},{"issue":"1","key":"2_CR94","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1083\/jcb.200411127","volume":"169","author":"Y Luo","year":"2005","unstructured":"Luo Y, Radice GL (2005) N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol 169(1):29\u201334","journal-title":"J Cell Biol"},{"issue":"3","key":"2_CR95","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/1097-0177(200007)218:3<472::AID-DVDY1008>3.0.CO;2-#","volume":"218","author":"H Gerhardt","year":"2000","unstructured":"Gerhardt H, Wolburg H, Redies C (2000) N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev Dyn 218(3):472\u2013479","journal-title":"Dev Dyn"},{"issue":"5","key":"2_CR96","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1161\/ATVBAHA.107.161521","volume":"29","author":"K Gaengel","year":"2009","unstructured":"Gaengel K et al (2009) Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol 29(5):630\u2013638","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"2_CR97","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1172\/JCI200317929","volume":"111","author":"G Bergers","year":"2003","unstructured":"Bergers G et al (2003) Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111(9):1287\u20131295","journal-title":"J Clin Invest"},{"issue":"9","key":"2_CR98","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1172\/JCI200318539","volume":"111","author":"P Saharinen","year":"2003","unstructured":"Saharinen P, Alitalo K (2003) Double target for tumor mass destruction. J Clin Invest 111(9):1277\u20131280","journal-title":"J Clin Invest"},{"issue":"14","key":"2_CR99","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1158\/1078-0432.CCR-07-0197","volume":"13","author":"C Lu","year":"2007","unstructured":"Lu C et al (2007) Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma. Clin Cancer Res 13(14):4209\u20134217","journal-title":"Clin Cancer Res"},{"issue":"6","key":"2_CR100","doi-asserted-by":"publisher","first-page":"6774","DOI":"10.18632\/oncotarget.6725","volume":"7","author":"C Brand","year":"2016","unstructured":"Brand C et al (2016) NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor. Oncotarget 7(6):6774\u20136789","journal-title":"Oncotarget"},{"issue":"12","key":"2_CR101","first-page":"2869","volume":"59","author":"MA Burg","year":"1999","unstructured":"Burg MA et al (1999) NG2 proteoglycan-binding peptides target tumor neovasculature. Cancer Res 59(12):2869\u20132874","journal-title":"Cancer Res"},{"issue":"3","key":"2_CR102","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3390\/cells2030621","volume":"2","author":"SJ Mills","year":"2013","unstructured":"Mills SJ, Cowin AJ, Kaur P (2013) Pericytes, mesenchymal stem cells and the wound healing process. Cell 2(3):621\u2013634","journal-title":"Cell"},{"key":"2_CR103","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.pharmthera.2016.11.006","volume":"171","author":"D Sa da Bandeira","year":"2017","unstructured":"Sa da Bandeira D, Casamitjana J, Crisan M (2017) Pericytes, integral components of adult hematopoietic stem cell niches. Pharmacol Ther 171:104\u2013113","journal-title":"Pharmacol Ther"},{"issue":"3","key":"2_CR104","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","volume":"8","author":"M Palma De","year":"2005","unstructured":"De Palma M et al (2005) Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211\u2013226","journal-title":"Cancer Cell"},{"issue":"3","key":"2_CR105","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1189\/jlb.0303114","volume":"75","author":"GJ Guillemin","year":"2004","unstructured":"Guillemin GJ, Brew BJ (2004) Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 75(3):388\u2013397","journal-title":"J Leukoc Biol"},{"issue":"4","key":"2_CR106","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.2353\/ajpath.2010.090786","volume":"176","author":"SB Coffelt","year":"2010","unstructured":"Coffelt SB et al (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. Am J Pathol 176(4):1564\u20131576","journal-title":"Am J Pathol"}],"container-title":["Advances in Experimental Medicine and Biology","Pericyte Biology - Novel Concepts"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-02601-1_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T15:40:37Z","timestamp":1662565237000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-02601-1_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783030026004","9783030026011"],"references-count":106,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-02601-1_2","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"7 December 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}