{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:31:04Z","timestamp":1759602664539},"publisher-location":"Cham","reference-count":25,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030046149"},{"type":"electronic","value":"9783030046156"}],"license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-04615-6_3","type":"book-chapter","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T13:03:33Z","timestamp":1565615013000},"page":"15-19","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Heparin Treatment in Aneurysmal Subarachnoid Hemorrhage: A Review of Human Studies"],"prefix":"10.1007","author":[{"given":"Nicolas K.","family":"Khattar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Bak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1161\/STROKEAHA.110.581975","volume":"41","author":"T Al-Khindi","year":"2010","unstructured":"Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke. 2010;41:e519\u201336.","journal-title":"Stroke"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1136\/neurintsurg-2016-012925","volume":"9","author":"M Bruder","year":"2017","unstructured":"Bruder M, Won S-YY, Kashefiolasl S, Wagner M, Brawanski N, Dinc N, Seifert V, Konczalla J. Effect of heparin on secondary brain injury in patients with subarachnoid hemorrhage: an additional \u2018H\u2019 therapy in vasospasm treatment. J Neurointerv Surg. 2017;9:659\u201363.","journal-title":"J Neurointerv Surg"},{"key":"3_CR3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.23736\/S0390-5616.16.03921-7","volume":"61","author":"MG Crowley","year":"2017","unstructured":"Crowley MG, Liska MG, Borlongan CV. Stem cell therapy for sequestering neuroinflammation in traumatic brain injury: an update on exosome-targeting to the spleen. J Neurosurg Sci. 2017;61:291\u2013302.","journal-title":"J Neurosurg Sci"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1182\/blood-2002-07-2201","volume":"101","author":"B Girolami","year":"2003","unstructured":"Girolami B, Prandoni P, Stefani PM, Tanduo C, Sabbion P, Eichler P, Ramon R, Baggio G, Fabris F, Girolami A. The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study. Blood. 2003;101:2955\u20139.","journal-title":"Blood"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jcrc.2011.09.005","volume":"27","author":"RI Hacker","year":"2012","unstructured":"Hacker RI, Ritter G, Nelson C, Knobel D, Gupta R, Hopkins K, Marini CP, Barrera R. Subcutaneous heparin does not increase postoperative complications in neurosurgical patients: an institutional experience. J Crit Care. 2012;27:250\u20134.","journal-title":"J Crit Care"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1212\/01.WNL.0000110187.16764.9A","volume":"62","author":"U Harbrecht","year":"2004","unstructured":"Harbrecht U, Bastians B, Kredteck A, Hanfland P, Klockgether T, Pohl C. Heparin-induced thrombocytopenia in neurologic disease treated with unfractionated heparin. Neurology. 2004;62:657\u20139.","journal-title":"Neurology"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1191\/026921599669500092","volume":"13","author":"DJ Hellawell","year":"1999","unstructured":"Hellawell DJ, Taylor R, Pentland B. Persisting symptoms and carers\u2019 views of outcome after subarachnoid haemorrhage. Clin Rehabil. 1999;13:333\u201340.","journal-title":"Clin Rehabil"},{"key":"3_CR8","unstructured":"James RF, Khattar NK, Aljuboori ZS, Page P, Shao EY, Carter LM, Meyer KS, Daniels MJ, Craycroft J, Gaughen JR Jr, Chaudry MI, Rai SN, Everhart DE, Simard JM. Continuous infusion of low-dose unfractionated heparin after aneurysmal subarachnoid hemorrhage: a preliminary study of cognitive outcomes. J Neurosurg. 2018;11:1\u20138. https:\/\/doi.org\/10.317.1\/2017.11.JNS17894 [Epub ahead of print]."},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1161\/hs0102.101080","volume":"33","author":"KT Kreiter","year":"2002","unstructured":"Kreiter KT, Copeland D, Bernardini GL, Bates JE, Peery S, Claassen J, Du YE, Stern Y, Connolly ES, Mayer SA. Predictors of cognitive dysfunction after subarachnoid hemorrhage. Stroke. 2002;33:200\u20138.","journal-title":"Stroke"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1017\/cjn.2014.16","volume":"41","author":"AL Manoel","year":"2014","unstructured":"Manoel AL, Turkel-Parrella D, Germans M, Kouzmina E, Almendra Pda S, Marotta T, Spears J, Abrahamson S. Safety of early pharmacological thromboprophylaxis after subarachnoid hemorrhage. Can J Neurol Sci. 2014;41:554\u201361.","journal-title":"Can J Neurol Sci"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3171\/jns.1999.91.3.0402","volume":"91","author":"N Mavaddat","year":"1999","unstructured":"Mavaddat N, Sahakian BJ, Hutchinson PJ, Kirkpatrick PJ. Cognition following subarachnoid hemorrhage from anterior communicating artery aneurysm: relation to timing of surgery. J Neurosurg. 1999;91:402\u20137.","journal-title":"J Neurosurg"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1227\/01.NEU.0000153925.96889.8A","volume":"56","author":"A Parra","year":"2005","unstructured":"Parra A, Kreiter KT, Williams S, Sciacca R, Mack WJ, Naidech AM, Commichau CS, Fitzsimmons BF, Janjua N, Mayer SA, Connolly ES Jr. Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study. Neurosurgery. 2005;56:476\u201384; discussion 476\u201384.","journal-title":"Neurosurgery"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1055\/s-2005-923537","volume":"25","author":"JJ Provencio","year":"2005","unstructured":"Provencio JJ, Vora N. Subarachnoid hemorrhage and inflammation: bench to bedside and back. Semin Neurol. 2005;25:435\u201344.","journal-title":"Semin Neurol"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1179\/174313209X393906","volume":"31","author":"GJ Pyne-Geithman","year":"2009","unstructured":"Pyne-Geithman GJ, Caudell DN, Prakash P, Clark JF. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol Res. 2009;31:195\u20139.","journal-title":"Neurol Res"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3171\/jns.2003.99.6.0953","volume":"99","author":"J Siironen","year":"2003","unstructured":"Siironen J, Juvela S, Varis J, Porras M, Poussa K, Ilveskero S, Hernesniemi J, Lassila R. No effect of enoxaparin on outcome of aneurysmal subarachnoid hemorrhage: a randomized, double-blind, placebo-controlled clinical trial. J Neurosurg. 2003;99:953\u20139.","journal-title":"J Neurosurg"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3171\/2013.8.JNS1337","volume":"119","author":"JM Simard","year":"2013","unstructured":"Simard JM, Aldrich EF, Schreibman D, James RF, Polifka A, Beaty N. Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment. J Neurosurg. 2013;119:1611\u20139.","journal-title":"J Neurosurg"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s12028-010-9435-1","volume":"13","author":"JM Simard","year":"2010","unstructured":"Simard JM, Schreibman D, Aldrich EF, Stallmeyer B, Le B, James RF, Beaty N. Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage. Neurocrit Care. 2010;13:439\u201349.","journal-title":"Neurocrit Care"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12975-012-0166-9","volume":"3","author":"JM Simard","year":"2012","unstructured":"Simard JM, Tosun C, Ivanova S, Kurland DB, Hong C, Radecki L, Gisriel C, Mehta R, Schreibman D, Gerzanich V. Heparin reduces neuroinflammation and transsynaptic neuronal apoptosis in a model of subarachnoid hemorrhage. Transl Stroke Res. 2012;3:155\u201365.","journal-title":"Transl Stroke Res"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/foc.2006.21.3.2","volume":"21","author":"SC Stein","year":"2006","unstructured":"Stein SC, Levine JM, Nagpal S, LeRoux PD. Vasospasm as the sole cause of cerebral ischemia: how strong is the evidence? Neurosurg Focus. 2006;21:E2.","journal-title":"Neurosurg Focus"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/jcbfm.2008.74","volume":"28","author":"MD Vergouwen","year":"2008","unstructured":"Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB. Microthrombosis after aneurysmal subarachnoid hemorrhage: an additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:1761\u201370.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fneur.2017.00268","volume":"8","author":"A Wessell","year":"2017","unstructured":"Wessell A, Kole MJ, Badjatia N, Parikh G, Albrecht JS, Schreibman DL, Simard JM. High compliance with scheduled nimodipine is associated with better outcome in aneurysmal subarachnoid hemorrhage patients cotreated with heparin infusion. Front Neurol. 2017;8:268.","journal-title":"Front Neurol"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.clineuro.2004.01.006","volume":"106","author":"G Wurm","year":"2004","unstructured":"Wurm G, Tomancok B, Nussbaumer K, Adelwohrer C, Holl K. Reduction of ischemic sequelae following spontaneous subarachnoid hemorrhage: a double-blind, randomized comparison of enoxaparin versus placebo. Clin Neurol Neurosurg. 2004;106:97\u2013103.","journal-title":"Clin Neurol Neurosurg"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.thromres.2006.10.026","volume":"122","author":"E Young","year":"2008","unstructured":"Young E. The anti-inflammatory effects of heparin and related compounds. Thromb Res. 2008;122:743\u201352.","journal-title":"Thromb Res"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s12028-016-0262-x","volume":"25","author":"J Zachariah","year":"2016","unstructured":"Zachariah J, Snyder KA, Graffeo CS, Khanal DR, Lanzino G, Wijdicks EF, Rabinstein AA. Risk of ventriculostomy-associated hemorrhage in patients with aneurysmal subarachnoid hemorrhage treated with anticoagulant thromboprophylaxis. Neurocrit Care. 2016;25:224\u20139.","journal-title":"Neurocrit Care"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1179\/016164106X151990","volume":"28","author":"ZD Zhang","year":"2006","unstructured":"Zhang ZD, Macdonald RL. Contribution of the remodeling response to cerebral vasospasm. Neurol Res. 2006;28:713\u201320.","journal-title":"Neurol Res"}],"container-title":["Acta Neurochirurgica Supplement","Subarachnoid Hemorrhage"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-04615-6_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T13:29:33Z","timestamp":1664112573000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-04615-6_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"ISBN":["9783030046149","9783030046156"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-04615-6_3","relation":{},"ISSN":["0065-1419","2197-8395"],"issn-type":[{"type":"print","value":"0065-1419"},{"type":"electronic","value":"2197-8395"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"13 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}