{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T09:37:18Z","timestamp":1743154638875,"version":"3.40.3"},"publisher-location":"Cham","reference-count":24,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030105488"},{"type":"electronic","value":"9783030105495"}],"license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-10549-5_49","type":"book-chapter","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:03:31Z","timestamp":1546214611000},"page":"626-637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GPU Accelerated Analysis of Treg-Teff Cross Regulation in Relapsing-Remitting Multiple Sclerosis"],"prefix":"10.1007","author":[{"given":"Marco","family":"Beccuti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Cazzaniga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzio","family":"Pennisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Besozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco S.","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Pernice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tangherloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"issue":"1","key":"49_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.peva.2010.09.002","volume":"68","author":"S Baarir","year":"2010","unstructured":"Baarir, S., Beccuti, M., Dutheillet, C., Franceschinis, G., Haddad, S.: Lumping partially symmetrical stochastic models. Perform. Eval. 68(1), 21\u201344 (2010)","journal-title":"Perform. Eval."},{"key":"49_CR2","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/978-3-642-13675-7_19","volume-title":"Applications and Theory of Petri Nets","author":"J Babar","year":"2010","unstructured":"Babar, J., Beccuti, M., Donatelli, S., Miner, A.: GreatSPN enhanced with decision diagram data structures. In: Lilius, J., Penczek, W. (eds.) PETRI NETS 2010. LNCS, vol. 6128, pp. 308\u2013317. Springer, Heidelberg (2010). https:\/\/doi.org\/10.1007\/978-3-642-13675-7_19"},{"issue":"1","key":"49_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/comjnl\/bxt111","volume":"58","author":"M Beccuti","year":"2015","unstructured":"Beccuti, M., et al.: From symmetric nets to differential equations exploiting model symmetries. Comput. J. 58(1), 23\u201339 (2015)","journal-title":"Comput. J."},{"key":"49_CR4","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/978-3-319-40189-8_3","volume-title":"Pursuit of the Universal","author":"D Besozzi","year":"2016","unstructured":"Besozzi, D.: Reaction-based models of biochemical networks. In: Beckmann, A., Bienvenu, L., Jonoska, N. (eds.) CiE 2016. LNCS, vol. 9709, pp. 24\u201334. Springer, Cham (2016). https:\/\/doi.org\/10.1007\/978-3-319-40189-8_3"},{"key":"49_CR5","doi-asserted-by":"crossref","unstructured":"Besozzi, D., Cazzaniga, P., Pescini, D., Mauri, G., Colombo, S., Martegani, E.: The role of feedback control mechanisms on the establishment of oscillatory regimes in the Ras\/cAMP\/PKA pathway in S. cerevisiae. EURASIP J. Bioinf. Syst. Biol. 2012(1), 10 (2012)","DOI":"10.1186\/1687-4153-2012-10"},{"issue":"11","key":"49_CR6","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1109\/12.247838","volume":"42","author":"G Chiola","year":"1993","unstructured":"Chiola, G., Dutheillet, C., Franceschinis, G., Haddad, S.: Stochastic well-formed coloured nets for symmetric modelling applications. IEEE Trans. Comput. 42(11), 1343\u20131360 (1993)","journal-title":"IEEE Trans. Comput."},{"issue":"9648","key":"49_CR7","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston, A., Coles, A.: Multiple sclerosis. The Lancet 372(9648), 1502\u20131517 (2008)","journal-title":"The Lancet"},{"key":"49_CR8","volume-title":"McAlpine\u2019s Multiple Sclerosis","author":"G Compston","year":"2013","unstructured":"Compston, G., et al.: McAlpine\u2019s Multiple Sclerosis, 4th edn. Elsevier, Amsterdam (2013)","edition":"4"},{"issue":"4","key":"49_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/ni1179","volume":"6","author":"JD Fontenot","year":"2005","unstructured":"Fontenot, J.D., Rudensky, A.Y.: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6(4), 331\u2013337 (2005)","journal-title":"Nat. Immunol."},{"key":"49_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0021-9991(76)90041-3","volume":"22","author":"DT Gillespie","year":"1976","unstructured":"Gillespie, D.T.: A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J. Comput. Phys. 22, 403\u2013434 (1976)","journal-title":"J. Comput. Phys."},{"issue":"2","key":"49_CR11","doi-asserted-by":"publisher","first-page":"e4565","DOI":"10.1371\/journal.pone.0004565","volume":"4","author":"DS Goodin","year":"2009","unstructured":"Goodin, D.S.: The causal cascade to multiple sclerosis: a model for MS pathogenesis. PLoS One 4(2), e4565 (2009)","journal-title":"PLoS One"},{"issue":"7","key":"49_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2307\/3212147","volume":"1","author":"TG Kurtz","year":"1970","unstructured":"Kurtz, T.G.: Solutions of ordinary differential equations as limits of pure jump Markov processes. J. Appl. Probab. 1(7), 49\u201358 (1970)","journal-title":"J. Appl. Probab."},{"issue":"5880","key":"49_CR13","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1126\/science.1155209","volume":"320","author":"JM Lund","year":"2008","unstructured":"Lund, J.M., Hsing, L., Pham, T.T., Rudensky, A.Y.: Coordination of early protective immunity to viral infection by regulatory T cells. Science 320(5880), 1220\u20131224 (2008)","journal-title":"Science"},{"key":"49_CR14","volume-title":"Lehninger Principles of Biochemistry","author":"DL Nelson","year":"2004","unstructured":"Nelson, D.L., Cox, M.M.: Lehninger Principles of Biochemistry. W. H. FreemanCo., New York (2004)"},{"issue":"1","key":"49_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11227-014-1208-8","volume":"69","author":"MS Nobile","year":"2014","unstructured":"Nobile, M.S., Besozzi, D., Cazzaniga, P., Mauri, G.: GPU-accelerated simulations of mass-action kinetics models with cupSODA. J. Supercomput. 69(1), 17\u201324 (2014)","journal-title":"J. Supercomput."},{"issue":"Suppl 16","key":"49_CR16","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1186\/1471-2105-14-S16-S9","volume":"14","author":"M Pennisi","year":"2013","unstructured":"Pennisi, M., Rajput, A.M., Toldo, L., Pappalardo, F.: Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis. BMC Bioinform. 14(Suppl 16), S9 (2013)","journal-title":"BMC Bioinform."},{"issue":"1\u20132","key":"49_CR17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jns.2009.03.028","volume":"286","author":"D Pohl","year":"2009","unstructured":"Pohl, D.: An altered immune response to Epstein-Barr virus in multiple sclerosis. J. Neurol. Sci. 286(1\u20132), 62\u20134 (2009)","journal-title":"J. Neurol. Sci."},{"issue":"4","key":"49_CR18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1001\/jama.293.4.463","volume":"293","author":"AL Ponsonby","year":"2005","unstructured":"Ponsonby, A.L., et al.: Exposure to infant siblings during early life and risk of multiple sclerosis. JAMA 293(4), 463\u2013469 (2005)","journal-title":"JAMA"},{"key":"49_CR19","doi-asserted-by":"crossref","unstructured":"Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M.: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155(3), 1152\u20131164 (1995)","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"49_CR20","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","volume":"23","author":"M Sospedra","year":"2005","unstructured":"Sospedra, M., Martin, R.: Immunology of multiple sclerosis. Annu. Rev. Immunol. 23, 683\u2013747 (2005)","journal-title":"Annu. Rev. Immunol."},{"key":"49_CR21","doi-asserted-by":"crossref","DOI":"10.1515\/9780691223384","volume-title":"Introduction to the Numerical Solution of Markov Chains","author":"WJ Stewart","year":"1995","unstructured":"Stewart, W.J.: Introduction to the Numerical Solution of Markov Chains. Princeton University Press, Princeton (1995)"},{"issue":"1","key":"49_CR22","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12859-017-1666-0","volume":"18","author":"A Tangherloni","year":"2017","unstructured":"Tangherloni, A., Nobile, M.S., Besozzi, D., Mauri, G., Cazzaniga, P.: LASSIE: simulating large-scale models of biochemical systems on GPUs. BMC Bioinform. 18(1), 246 (2017)","journal-title":"BMC Bioinform."},{"key":"49_CR23","doi-asserted-by":"crossref","unstructured":"V\u00e9lez De Mendiz\u00e1bal, N., et al.: Modeling the effector-regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Syst. Biol. 5, 114 (2011)","DOI":"10.1186\/1752-0509-5-114"},{"issue":"3","key":"49_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/WCO.0000000000000205","volume":"28","author":"SK Yadav","year":"2015","unstructured":"Yadav, S.K., Mindur, J.E., Ito, K., Dhib-Jalbut, S.: Advances in the immunopathogenesis of multiple sclerosis. Curr. Opin. Neurol. 28(3), 206\u2013219 (2015)","journal-title":"Curr. Opin. Neurol."}],"container-title":["Lecture Notes in Computer Science","Euro-Par 2018: Parallel Processing Workshops"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-10549-5_49","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T08:43:05Z","timestamp":1672562585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-10549-5_49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,31]]},"ISBN":["9783030105488","9783030105495"],"references-count":24,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-10549-5_49","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2018,12,31]]},"assertion":[{"value":"31 December 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Euro-Par","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"European Conference on Parallel Processing","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Turin","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Italy","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2018","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"27 August 2018","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"31 August 2018","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"24","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"europar2018","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/europar2018.org\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}