{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:01:05Z","timestamp":1793383265131,"version":"4.5.0"},"publisher-location":"Cham","reference-count":154,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030151379","type":"print"},{"value":"9783030151386","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-15138-6_3","type":"book-chapter","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T10:10:00Z","timestamp":1558606200000},"page":"53-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Genetic Polymorphisms in Inflammatory and Other Regulators in Gastric Cancer: Risks and Clinical Consequences"],"prefix":"10.1007","author":[{"given":"Karolina","family":"Rudnicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Backert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Chmiela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.micpath.2017.04.007","volume":"107","author":"E Abdi","year":"2017","unstructured":"Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Safaralizadeh R (2017) Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran. Microb Pathog 107:287\u2013292. \n                  https:\/\/doi.org\/10.1016\/j.micpath.2017.04.007","journal-title":"Microb Pathog"},{"key":"3_CR2","doi-asserted-by":"publisher","unstructured":"Al-Sammak F, Kalinski T, Weinert S, Link A, Wex T, Malfertheiner P (2013) Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in humans: is it head or tail of the coin? PLoS One 17 8(9):e75192. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0075192","DOI":"10.1371\/journal.pone.0075192"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.3748\/wjg.v20.i36.12767","volume":"20","author":"S Alzahrani","year":"2014","unstructured":"Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE (2014) Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol 20:12767\u201312780. \n                  https:\/\/doi.org\/10.3748\/wjg.v20.i36.12767","journal-title":"World J Gastroenterol"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.humimm.2012.04.011","volume":"73","author":"T Arisawa","year":"2012","unstructured":"Arisawa T, Tahara T, Shiroeda H, Matsue Y, Minato T, Nomura T, Yamada H, Hayashi R, Saito T, Matsunaga K, Fukuyama T, Hayashi N, Otsuka T, Fukumura A, Nakamura M, Shibata T (2012) Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A3\u2019-UTR, influence susceptibility to gastric cancer. Human Immunol 73:747\u2013752. \n                  https:\/\/doi.org\/10.1016\/j.humimm.2012.04.011","journal-title":"Human Immunol"},{"key":"3_CR5","doi-asserted-by":"publisher","unstructured":"Aspholm M, Olfat F, Nord\u00e9n J, Sond\u00e9n B, Lundberg C, Sj\u00f6str\u00f6m R, Altraja S, Odenbreit S, Haas R, Wadstr\u00f6m T, Engstrand L, Semino-Mora C, Liu H, Dubois A, Teneberg S, Arnqvist A, Bor\u00e9n T (2006) SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. PLoS Pathog 2(10):e110. \n                  https:\/\/doi.org\/10.1371\/journal.ppat.0020110","DOI":"10.1371\/journal.ppat.0020110"},{"issue":"11","key":"3_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.tim.2010.08.003","volume":"18","author":"S Backert","year":"2010","unstructured":"Backert S, Naumann M (2010) What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol 18(11):479\u2013486. \n                  https:\/\/doi.org\/10.1016\/j.tim.2010.08.003","journal-title":"Trends Microbiol"},{"issue":"2","key":"3_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.tibs.2007.10.006","volume":"33","author":"S Backert","year":"2008","unstructured":"Backert S, Feller SM, Wessler S (2008) Emerging roles of Abl family tyrosine kinases in microbial pathogenesis. Trends Biochem Sci 33(2):80\u201390. \n                  https:\/\/doi.org\/10.1016\/j.tibs.2007.10.006","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"3_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1523-5378.2010.00759.x","volume":"15","author":"S Backert","year":"2010","unstructured":"Backert S, Tegtmeyer N, Selbach M (2010) The versatility of Helicobacter pylori CagA effector protein functions: the master key hypothesis. Helicobacter 15(3):163\u2013176. \n                  https:\/\/doi.org\/10.1111\/j.1523-5378.2010.00759.x","journal-title":"Helicobacter"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"955","DOI":"10.2217\/fmb.15.32","volume":"10","author":"S Backert","year":"2015","unstructured":"Backert S, Tegtmeyer N, Fischer W (2015) Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiol 10:955\u2013965. \n                  https:\/\/doi.org\/10.2217\/fmb.15.32","journal-title":"Future Microbiol"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-3-319-75241-9_8","volume":"413","author":"S Backert","year":"2017","unstructured":"Backert S, Haas R, Gerhard M, Naumann M (2017) The Helicobacter pylori Type IV secretion system encoded by the cag pathogenicity island: architecture, function, and signaling. Curr Top Microbiol Immunol 413:187\u2013220. \n                  https:\/\/doi.org\/10.1007\/978-3-319-75241-9_8","journal-title":"Curr Top Microbiol Immunol"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.clinre.2013.12.004","volume":"38","author":"N Bagheri","year":"2014","unstructured":"Bagheri N, Azadegan-Dehkordi F, Sanei H, Taghikhani A, Rahimian G, Salimzadeh L, Hashemzadeh-Chaleshtori M, Rafieian-kopaei M, Shirzad M, Shirzad H (2014) Association of TLR4 single-nucleotide polymorphism with H. pylori associated gastric diseases in Iranian patients. Clin Res Hepatol Gastroenterol 38:366\u2013371. \n                  https:\/\/doi.org\/10.1016\/j.clinre.2013.12.004","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539\u2013545. \n                  https:\/\/doi.org\/10.1016\/S0140-6736(00)04046-0","journal-title":"Lancet"},{"issue":"11","key":"3_CR13","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.str.2013.08.018","volume":"21","author":"S Barden","year":"2013","unstructured":"Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH (2013) A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL. Structure\u00a021(11):1931\u20131941. \n                  https:\/\/doi.org\/10.1016\/j.str.2013.08.018","journal-title":"Structure"},{"issue":"1","key":"3_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1053\/j.gastro.2008.03.041","volume":"135","author":"D Basso","year":"2008","unstructured":"Basso D, Zambon CF, Letley DP, Stranges A, Marchet A, Rhead JL, Schiavon S, Guariso G, Ceroti M, Nitti D, Rugge M, Plebani M, Atherton JC (2008) Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 135(1):91\u201399. \n                  https:\/\/doi.org\/10.1053\/j.gastro.2008.03.041","journal-title":"Gastroenterology"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2180-11-61","volume":"11","author":"SA Batista","year":"2011","unstructured":"Batista SA, Rocha GA, Rocha AM, Saraiva IE, Cabral MM, Oliveira RC, Queiroz DM (2011) Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol 11:61. \n                  https:\/\/doi.org\/10.1186\/1471-2180-11-61","journal-title":"BMC Microbiol"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1152\/physrev.00040.2012","volume":"94","author":"A Bhattacharyya","year":"2014","unstructured":"Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 94:329\u2013354. \n                  https:\/\/doi.org\/10.1152\/physrev.00040.2012","journal-title":"Physiol Rev"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jcmgh.2017.03.005","volume":"4","author":"KA Bockerstett","year":"2017","unstructured":"Bockerstett KA, DiPaolo RJ (2017) Regulation of gastric carcinogenesis by inflammatory cytokines. Cell Mol Gastroenterol Hepatol 4:47\u201353. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2017.03.005","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri3834","volume":"15","author":"D Brenner","year":"2015","unstructured":"Brenner D, Blaser H, Mak TW (2015) Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol 15:362\u2013374. \n                  https:\/\/doi.org\/10.1038\/nri3834","journal-title":"Nat Rev Immunol"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4161\/gmic.23797","volume":"4","author":"DR Bridge","year":"2013","unstructured":"Bridge DR, Merrell DS (2013) Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease. Gut Microbes 4:101\u2013117. \n                  https:\/\/doi.org\/10.4161\/gmic.23797","journal-title":"Gut Microbes"},{"issue":"1","key":"3_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.femsle.2005.06.008","volume":"249","author":"M Brisslert","year":"2005","unstructured":"Brisslert M, Enarsson K, Lundin S, Karlsson A, Kusters JG, Svennerholm AM, Backert S, Quiding-J\u00e4rbrink M (2005) Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP. FEMS Microbiol Lett 249(1):95\u2013103","journal-title":"FEMS Microbiol Lett"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jcmgh.2017.02.002","volume":"3","author":"LD Butcher","year":"2017","unstructured":"Butcher LD, den Hartog G, Ernst PB, Crowe SE (2017) Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis. Cell Mol Gastroenterol Hepatol 3:316\u2013322. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.002","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jcmgh.2014.12.003","volume":"1","author":"JN Buzzeli","year":"2015","unstructured":"Buzzeli JN, Chalinor HV, Pavlic DI, Sutton P, Menheniott TR, Giraud AS, Judd LM (2015) IL-33 is a stomach alarmin that initiates a skewed Th2 response to injury and infection. Cell Mol Gastroenterol Hepatol 1:203\u2013221. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2014.12.003","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1678-9199-20-17","volume":"20","author":"A Caleman Neto","year":"2014","unstructured":"Caleman Neto A, Rasmussen LT, de Labio RW, de Queiroz VF, Smith Mde A, Viani GA, Pay\u00e3o SL (2014) Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori. J Venom Anim Toxins Incl Trop Dis 20:17. \n                  https:\/\/doi.org\/10.1186\/1678-9199-20-17","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"issue":"1","key":"3_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/CEJ.0b013e32809b4d0f","volume":"17","author":"P Canedo","year":"2008","unstructured":"Canedo P, Castanheira-Vale AJ, Lunet N, Pereira F, Figueiredo C, Gioia-Patricola L, Canzian F, Moreira H, Suriano G, Barros H, Carneiro F, Seruca R, Machado JC (2008) The interleukin-8-251*T\/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. Eur J Cancer Prev 17(1):28\u201332","journal-title":"Eur J Cancer Prev"},{"issue":"6","key":"3_CR25","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1093\/ije\/dyn145","volume":"37","author":"G Capell\u00e1","year":"2008","unstructured":"Capell\u00e1 G, Pera G, Sala N, Agudo A, Rico F, Del Giudicce G, Plebani M, Palli D, Boeing H, Bueno-de-Mesquita HB, Carneiro F, Berrino F, Vineis P, Tumino R, Panico S, Berglund G, Sim\u00e1n H, Nyr\u00e9n O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quir\u00f3s JR, Allen N, Key T, Bingham S, Caldas C, Linseisen J, Nagel G, Overvad K, Tjonneland A, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Kaaks R, Riboli E, Gonz\u00e1lez CA (2008) DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. Int J Epidemiol 37(6):1316\u20131325. \n                  https:\/\/doi.org\/10.1093\/ije\/dyn145","journal-title":"Int J Epidemiol"},{"key":"3_CR26","doi-asserted-by":"publisher","first-page":"e60327","DOI":"10.1371\/journal.pone.0060327","volume":"8","author":"N Casta\u00f1o-Rodr\u00edguez","year":"2013","unstructured":"Casta\u00f1o-Rodr\u00edguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2013) The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta analysis. PLoS ONE 8:e60327. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0060327","journal-title":"PLoS ONE"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fimmu.2014.00336","volume":"5","author":"N Casta\u00f1o-Rodr\u00edguez","year":"2014","unstructured":"Casta\u00f1o-Rodr\u00edguez N, Kaakoush NO, Mitchell HM (2014) Pattern-recognition receptors and gastric cancer. Front Immunol 5:336. \n                  https:\/\/doi.org\/10.3389\/fimmu.2014.00336","journal-title":"Front Immunol"},{"key":"3_CR28","doi-asserted-by":"publisher","unstructured":"Chen S, Zhu XC, Liu YL, Wang C, Zhang KG (2016a) Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer. Genet Mol Res. 15(3). \n                  https:\/\/doi.org\/10.4238\/gmr.15038342","DOI":"10.4238\/gmr.15038342"},{"issue":"44","key":"3_CR29","doi-asserted-by":"publisher","first-page":"9718","DOI":"10.3748\/wjg.v22.i44.9718","volume":"22","author":"YL Chen","year":"2016","unstructured":"Chen YL, Mo XQ, Huang GR, Huang YQ, Xiao J, Zhao LJ, Wei HY (2016b) Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal disease. World J Gastroenterol 22(44):9718\u20139726. \n                  https:\/\/doi.org\/10.3748\/wjg.v22.i44.9718","journal-title":"World J Gastroenterol"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.3748\/wjg.v19.i42.7361","volume":"19","author":"J Cheng","year":"2013","unstructured":"Cheng J, Fan XM (2013) Role of cyclooxygenase-2 in gastric cancer development and progression. World J Gastroenterol 19:7361\u20137368. \n                  https:\/\/doi.org\/10.3748\/wjg.v19.i42.7361","journal-title":"World J Gastroenterol"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.micpath.2017.04.025","volume":"107","author":"MR Cherati","year":"2017","unstructured":"Cherati MR, Shokri-Shirvani J, Karkhah A, Rajabnia R, Nouri HR (2017) Helicobacter pylori cagL amino acid polymorphism D58E59 pave the way toward peptic ulcer disease while N58E59 is associated with gastric cancer in north of Iran. Microb Pathog 107:413\u2013418. \n                  https:\/\/doi.org\/10.1016\/j.micpath.2017.04.025","journal-title":"Microb Pathog"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"9882","DOI":"10.3748\/wjg.v20.i29.9882","volume":"20","author":"M Chmiela","year":"2014","unstructured":"Chmiela M, Miszczyk K, Rudnicka K (2014) Structural modifications of Helicobacter pylori lipopolysaccharide: an idea how to live in peace. World J Gastroenterol 20:9882\u20139897. \n                  https:\/\/doi.org\/10.3748\/wjg.v20.i29.9882","journal-title":"World J Gastroenterol"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0140-6736(75)90498-5","volume":"2","author":"P Correa","year":"1975","unstructured":"Correa P, Haenszel W, Cuello C, Tannenbaum S, Archer M (1975) A model for gastric cancer epidemiology. Lancet 2:58\u201360","journal-title":"Lancet"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jcmgh.2017.01.012","volume":"3","author":"ES Demitrack","year":"2017","unstructured":"Demitrack ES, Samuelson LC (2017) Notch as a driver of gastric epithelial cell proliferation. Cell Mol Gastroenterol Hepatol 3:323\u2013330. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2017.01.012","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1086\/508426","volume":"194","author":"A Dossumbekova","year":"2006","unstructured":"Dossumbekova A, Prinz C, Mages J, Lang R, Kusters JG, Van Vliet AH, Reindl W, Backert S, Saur D, Schmid RM, Rad R (2006) Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis 194:1346\u20131355. \n                  https:\/\/doi.org\/10.1086\/508426","journal-title":"J Infect Dis"},{"key":"3_CR36","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/gut.48.6.743","volume":"48","author":"EM El-Omar","year":"2001","unstructured":"El-Omar EM (2001) The importance of interleukin 1\u03b2 in Helicobacter pylori associated disease. Gut 48:743\u2013747","journal-title":"Gut"},{"key":"3_CR37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0016-5085(97)70075-1","volume":"113","author":"EM El-Omar","year":"1997","unstructured":"El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, Williams C, Ardill JE, McColl KE (1997) Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 113:15\u201324. \n                  https:\/\/doi.org\/10.1016\/S0016-5085(97)70075-1","journal-title":"Gastroenterology"},{"issue":"6776","key":"3_CR38","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/35006081","volume":"404","author":"EM El-Omar","year":"2000","unstructured":"El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404(6776):398\u2013402. \n                  https:\/\/doi.org\/10.1038\/35006081","journal-title":"Nature"},{"key":"3_CR39","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1007\/s10552-013-0284-z","volume":"24","author":"M Epplein","year":"2013","unstructured":"Epplein M, Xiang YB, Cai Q, Peek RM Jr, Li H, Correa P, Gao J, Wu J, Michel A, Pawlita M, Zheng W, Shu XO (2013) Circulating cytokines and gastric cancer risk. Cancer Causes Control 24:2245\u20132250. \n                  https:\/\/doi.org\/10.1007\/s10552-013-0284-z","journal-title":"Cancer Causes Control"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1111\/j.1365-2559.2012.04190.x","volume":"60","author":"RM Ferreira","year":"2012","unstructured":"Ferreira RM, Machado JC, Leite M, Carneiro F, Figueiredo C (2012) The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. Histopathology 60:992\u2013998. \n                  https:\/\/doi.org\/10.1111\/j.1365-2559.2012.04190.x","journal-title":"Histopathology"},{"issue":"22","key":"3_CR41","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/jnci\/94.22.1680","volume":"94","author":"C Figueiredo","year":"2002","unstructured":"Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Sim\u00f5es M (2002) Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 94(22):1680\u20131687","journal-title":"J Natl Cancer Inst"},{"key":"3_CR42","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1074\/mcp.M900139-MCP200","volume":"8","author":"AT Franco","year":"2009","unstructured":"Franco AT, Friedman DB, Nagy TA, Romero-Gallo J, Krishna U, Kendall A, Israel DA, Tegtmeyer N, Washington MK, Peek RM Jr (2009) Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics 8:1947\u20131958. \n                  https:\/\/doi.org\/10.1074\/mcp.M900139-MCP200","journal-title":"Mol Cell Proteomics"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/bjc.2014.336","volume":"111","author":"H Fukui","year":"2014","unstructured":"Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, Kondo T, Tomita T, Oshima T, Watari J, Imura J, Fujimori T, Sasako M, Miwa H (2014) IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signalling. Br J Cancer 111:763\u2013771. \n                  https:\/\/doi.org\/10.1038\/bjc.2014.336","journal-title":"Br J Cancer"},{"issue":"2","key":"3_CR44","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/ijc.20718","volume":"114","author":"E Garza-Gonz\u00e1lez","year":"2005","unstructured":"Garza-Gonz\u00e1lez E, Bosques-Padilla FJ, El-Omar E, Hold G, Tijerina-Menchaca R, Maldonado-Garza HJ, P\u00e9rez-P\u00e9rez GI (2005) Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. Int J Cancer 114(2):237\u2013241. \n                  https:\/\/doi.org\/10.1002\/ijc.20718","journal-title":"Int J Cancer"},{"key":"3_CR45","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1136\/gutjnl-2015-310811","volume":"66","author":"GB Gifford","year":"2017","unstructured":"Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC (2017) Notch 1 and Notch 2 receptors regulate mouse and human gastric antral epithelial cell homeostasis. Gut 66:1001\u20131011. \n                  https:\/\/doi.org\/10.1136\/gutjnl-2015-310811","journal-title":"Gut"},{"issue":"5","key":"3_CR46","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/ajg.2011.1","volume":"106","author":"CA Gonz\u00e1lez","year":"2011","unstructured":"Gonz\u00e1lez CA, Figueiredo C, Lic CB, Ferreira RM, Pardo ML, Ruiz Liso JM, Alonso P, Sala N, Capella G, Sanz-Anquela JM (2011) Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: a long-term follow-up in a high-risk area in Spain. Am J Gastroenterol 106(5):867\u2013874. \n                  https:\/\/doi.org\/10.1038\/ajg.2011.1","journal-title":"Am J Gastroenterol"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1099\/mic.0.2007\/016055-0","volume":"154","author":"AC Goodwin","year":"2008","unstructured":"Goodwin AC, Weinberger DM, Ford CB, Nelson JC, Snider JD, Hall JD, Paules CI, Peek RM Jr, Forsyth MH (2008) Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system. Microbiology 154:2231\u20132240. \n                  https:\/\/doi.org\/10.1099\/mic.0.2007\/016055-0","journal-title":"Microbiology"},{"key":"3_CR48","first-page":"185","volume":"57","author":"A Grebowska","year":"2008","unstructured":"Grebowska A, Moran AP, Matusiak A, Bak-Romaniszyn L, Czkwianianc E, Rechci\u0144ski T, Walencka M, P\u0142aneta-Ma\u0142ecka I, Rudnicka W, Chmiela M (2008) Anti-phagocytic activity of Helicobacter pylori lipopolysaccharide (LPS)-possible modulation of the innate immune response to these bacteria. Pol J Microbiol 57:185\u2013192","journal-title":"Pol J Microbiol"},{"key":"3_CR49","first-page":"437","volume":"61","author":"A Grebowska","year":"2010","unstructured":"Grebowska A, Moran AP, Bielanski W, Matusiak A, Rechcinski T, Rudnicka K, Baranowska A, Rudnicka W, Chmiela M (2010) Helicobacter pylori lipopolysaccharide activity in human peripheral blood mononuclear leukocyte cultures. J Physiol Pharmacol 61:437\u2013442","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"3_CR50","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.celrep.2015.08.074","volume":"13","author":"ML Hartung","year":"2015","unstructured":"Hartung ML, Gruber DC, Koch KN, Gr\u00fcter L, Rehrauer H, Tegtmeyer N, Backert S, M\u00fcller A (2015) Helicobacter pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-\u03baB target gene expression. Cell Rep 13(1):70\u201379. \n                  https:\/\/doi.org\/10.1016\/j.celrep.2015.08.074","journal-title":"Cell Rep"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jcmgh.2017.02.009","volume":"4","author":"Y Hayakawa","year":"2017","unstructured":"Hayakawa Y, Fox JG, Wang TC (2017) Isthmus stem cells are the origins of metaplasia in the gastric corpus. Cell Mol Gastroenterol Hepatol 4:89\u201394. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2017.02.009","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1136\/gutjnl-2011-300539","volume":"61","author":"M Howlett","year":"2012","unstructured":"Howlett M, Chalinor HV, Buzzelli JN, Nguyen N, van Driel IR, Bell KM, Fox JG, Dimitriadis E, Menheniott TR, Giraud AS, Judd LM (2012) IL-11 is a parietal cell cytokine that induces atrophic gastritis. Gut 61:1398\u20131409. \n                  https:\/\/doi.org\/10.1136\/gutjnl-2011-300539","journal-title":"Gut"},{"key":"3_CR53","first-page":"881","volume":"26","author":"ZG Huang","year":"2010","unstructured":"Huang ZG, Tang GC (2010) Influence of Helicobacter pylori cagA gene of gastric mucosa epithelialcell tumor associated protein expression. Zhongguo Gonggongweishen Zazhi 26:881\u2013883","journal-title":"Zhongguo Gonggongweishen Zazhi"},{"key":"3_CR54","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1053\/j.gastro.2003.08.033","volume":"125","author":"JQ Huang","year":"2003","unstructured":"Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH (2003) Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 125:1636\u20131644","journal-title":"Gastroenterology"},{"key":"3_CR55","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1136\/gutjnl-2014-307595","volume":"64","author":"RH Hunt","year":"2015","unstructured":"Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, Sonnenberg A, Sugano K, Tack J (2015) The stomach in health and disease. Gut 64:1650\u20131668. \n                  https:\/\/doi.org\/10.1136\/gutjnl-2014-307595","journal-title":"Gut"},{"issue":"6","key":"3_CR56","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1053\/gast.2002.37043","volume":"123","author":"IR Hwang","year":"2002","unstructured":"Hwang IR, Kodama T, Kikuchi S, Sakai K, Peterson LE, Graham DY, Yamaoka Y (2002) Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology 123(6):1793\u20131803. \n                  https:\/\/doi.org\/10.1053\/gast.2002.37043","journal-title":"Gastroenterology"},{"key":"3_CR57","first-page":"1","volume":"61","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to humans","year":"1994","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to humans (1994) Schistosomes, liver flukes and Helicobacter pylori. IIARC Monogr Eval Carcinog Risks Hum 61:1\u2013241","journal-title":"IIARC Monogr Eval Carcinog Risks Hum"},{"issue":"5","key":"3_CR59","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1158\/1940-6207.capr-08-0109","volume":"1","author":"F Islami","year":"2008","unstructured":"Islami F, Kamangar F (2008) Helicobacter pylori and esophageal cancer risk: a meta-analysis. Cancer Prev Res (Phila) 1(5):329\u2013338. \n                  https:\/\/doi.org\/10.1158\/1940-6207.capr-08-0109","journal-title":"Cancer Prev Res (Phila)"},{"key":"3_CR60","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/path.1488","volume":"201","author":"PJ Jenks","year":"2003","unstructured":"Jenks PJ, Jeremy AH, Robinson PA, Walker MM, Crabtree JE (2003) Long term infection with Helicobacter felis and inactivation of the tumor suppressor gene p53 cumulatively enhance the gastrin mutation frequency in Big Blue\u00ae transgenic mice. J Pathol 201:596\u2013602. \n                  https:\/\/doi.org\/10.1002\/path.1488","journal-title":"J Pathol"},{"key":"3_CR61","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.gene.2015.07.018","volume":"572","author":"YX Jiang","year":"2015","unstructured":"Jiang YX, Li GM, Yi D, Yu PW (2015) A meta-analysis: The association between interleukin-17 pathway gene polymorphism and gastrointestinal diseases. Gene 572:243\u2013251. \n                  https:\/\/doi.org\/10.1016\/j.gene.2015.07.018","journal-title":"Gene"},{"key":"3_CR62","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1128\/JCM.01782-10","volume":"49","author":"KR Jones","year":"2011","unstructured":"Jones KR, Jang S, Chang JY, Kim J, Chung IS, Olsen CH, Merrell DS, Cha JH (2011) Polymorphisms in the intermediate region of VacA impact Helicobacter-pylori-induced disease development. J Clin Microbiol 49:101\u2013110. \n                  https:\/\/doi.org\/10.1128\/JCM.01782-10","journal-title":"J Clin Microbiol"},{"issue":"4","key":"3_CR63","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1159\/000336352","volume":"85","author":"T Kamada","year":"2012","unstructured":"Kamada T, Kurose H, Yamanaka Y, Manabe N, Kusunoki H, Shiotani A, Inoue K, Hata J, Matsumoto H, Akiyama T, Hirai T, Sadahira Y, Haruma K (2012) Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. Digestion 85(4):256\u2013260. \n                  https:\/\/doi.org\/10.1159\/000336352","journal-title":"Digestion"},{"issue":"1","key":"3_CR64","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10552-005-0439-7","volume":"17","author":"F Kamangar","year":"2006","unstructured":"Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, Pietinen P, Dawsey SM, Albanes D, Virtamo J, Taylor PR (2006) Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control 17(1):117\u2013125","journal-title":"Cancer Causes Control"},{"key":"3_CR65","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/1471-2180-11-104","volume":"11","author":"M Kawai","year":"2011","unstructured":"Kawai M, Furuta Y, Yahara K, Tsuru T, Oshima K, Handa N, Takahashi N, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I (2011) Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes. BCM Microbiol 11:104. \n                  https:\/\/doi.org\/10.1186\/1471-2180-11-104","journal-title":"BCM Microbiol"},{"key":"3_CR66","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1128\/IAI.00524-09","volume":"78","author":"W Khamri","year":"2010","unstructured":"Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G (2010) Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun 78:845\u2013853. \n                  https:\/\/doi.org\/10.1128\/IAI.00524-09","journal-title":"Infect Immun"},{"key":"3_CR67","doi-asserted-by":"publisher","first-page":"e29643","DOI":"10.1371\/journal.pone.0029643","volume":"7","author":"J Kim","year":"2012","unstructured":"Kim J, Cho YA, Choi IJ, Lee YS, Kim SY, Shin A, Cho SJ, Kook MC, Nam JH, Ryu KW, Lee JH, Kim YW (2012) Effects of Interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer. PLoS ONE 7:e29643. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0029643","journal-title":"PLoS ONE"},{"key":"3_CR68","doi-asserted-by":"publisher","unstructured":"Kim SG, Jung HK, Lee HL, Jang JY, Lee H, Kim CG, Shin WG, Shin ES, Lee YC (2013) Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition. Korean J Gastroenterol 62:3\u201326. \n                  https:\/\/doi.org\/10.4166\/kjg.2013.62.1.3","DOI":"10.4166\/kjg.2013.62.1.3"},{"key":"3_CR69","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.celrep.2015.05.030","volume":"11","author":"M Koeppel","year":"2015","unstructured":"Koeppel M, Garcia-Alcalde F, Glowinski F, Schlaermann P, Meyer TF (2015) Helicobacter pylori infection causes characteristic DNA damage patterns in human cells. Cell Rep 11:1703\u20131713. \n                  https:\/\/doi.org\/10.1016\/j.celrep.2015.05.030","journal-title":"Cell Rep"},{"issue":"7164","key":"3_CR70","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nature06187","volume":"449","author":"T Kwok","year":"2007","unstructured":"Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S (2007) Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449(7164):862\u2013866. \n                  https:\/\/doi.org\/10.1038\/nature06187","journal-title":"Nature"},{"key":"3_CR71","unstructured":"Latifi-Navid S, Mohammadi S, Maleki P, Zahri S, Yazdanbod A, Siavoshi F, Massarrat S (2013) Helicobacter pylori vacA d1\/-il genotypes and geographic differentiation between high and low incidence areas of gastric cancer in Iran. Arch Iran Med 16:330\u2013337. doi:013166\/AIM.005"},{"key":"3_CR72","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1053\/j.gastro.2016.01.028","volume":"150","author":"YC Lee","year":"2016","unstructured":"Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham DY (2016) Association between Helicobacter pylori eradication and gastric cancer incidence: a systemic review and meta-analysis. Gastroenterology 150:1113\u20131124. \n                  https:\/\/doi.org\/10.1053\/j.gastro.2016.01.028","journal-title":"Gastroenterology"},{"issue":"3","key":"3_CR73","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/carcin\/bgp018","volume":"30","author":"WQ Li","year":"2009","unstructured":"Li WQ, Zhang L, Ma JL, Zhang Y, Li JY, Pan KF, You WC (2009) Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. Carcinogenesis 30(3):500\u2013505. \n                  https:\/\/doi.org\/10.1093\/carcin\/bgp018","journal-title":"Carcinogenesis"},{"key":"3_CR74","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3892\/ol.2011.426","volume":"3","author":"Y Li","year":"2012","unstructured":"Li Y, Dai L, Zhang J, Wang P, Chai Y, Ye H, Zhang J, Wang K (2012) Cyclooxygenase-2 polymorphisms and the risk of gastric cancer in various degrees of relationship in the Chinese Han population. Oncol Lett 3:107\u2013112. \n                  https:\/\/doi.org\/10.3892\/ol.2011.426","journal-title":"Oncol Lett"},{"key":"3_CR75","doi-asserted-by":"publisher","unstructured":"Li ZX, Wang YM, Tang FB, Zhang L, Zhang, Ma JL, Zhou T, You WC, Pan KF (2015) NOD1 and NOD2 genetic variants in association with risk of gastric cancer and its precursors in a Chinese population. PLoS One 1 10(5):e0124949. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0124949","DOI":"10.1371\/journal.pone.0124949"},{"issue":"5","key":"3_CR77","doi-asserted-by":"publisher","first-page":"e96488","DOI":"10.1371\/journal.pone.0096488","volume":"9","author":"J Lind","year":"2014","unstructured":"Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N (2014) Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS ONE 9(5):e96488. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0096488","journal-title":"PLoS ONE"},{"issue":"1","key":"3_CR78","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12866-016-0820-6","volume":"16","author":"J Lind","year":"2016","unstructured":"Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N (2016) Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains. BMC Microbiol 16(1):201. \n                  https:\/\/doi.org\/10.1186\/s12866-016-0820-6","journal-title":"BMC Microbiol"},{"key":"3_CR79","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.humimm.2014.12.011","volume":"76","author":"J Liu","year":"2015","unstructured":"Liu J, Xu Q, Yuan Q, Wang Z, Xing C, Yuan Y (2015) Association of IL-17A and IL-17F polymorphisms with gastric cancer risk in Asians: a meta-analysis. Human Immunl 76:6\u201312. \n                  https:\/\/doi.org\/10.1016\/j.humimm.2014.12.011","journal-title":"Human Immunl"},{"key":"3_CR80","doi-asserted-by":"publisher","first-page":"e0176463","DOI":"10.1371\/journal.pone.0176463","volume":"4","author":"J Ma","year":"2017","unstructured":"Ma J, Wu D, Hu X, Li J, Cao M, Dong W (2017) Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis. PLoS ONE 4:e0176463. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0176463","journal-title":"PLoS ONE"},{"issue":"4","key":"3_CR81","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1053\/gast.2001.28000","volume":"121","author":"JC Machado","year":"2001","unstructured":"Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Sim\u00f5es M (2001) Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 121(4):823\u2013829","journal-title":"Gastroenterology"},{"issue":"2","key":"3_CR82","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0016-5085(03)00899-0","volume":"125","author":"JC Machado","year":"2003","unstructured":"Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Sim\u00f5es M (2003) A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 125(2):364\u2013371. \n                  https:\/\/doi.org\/10.1016\/S0016-5085(03)00899-0","journal-title":"Gastroenterology"},{"key":"3_CR83","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1158\/1078-0432.CCR-08-2686","volume":"15","author":"AM Machado","year":"2009","unstructured":"Machado AM, Figueiredo C, Touati E, M\u00e1ximo V, Sousa S, Michel V, Carneiro F, Nielsen FC, Seruca R, Rasmussen LJ (2009) Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res 15:2995\u20133002. \n                  https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-2686","journal-title":"Clin Cancer Res"},{"issue":"10","key":"3_CR84","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.mad.2013.08.004","volume":"134","author":"AM Machado","year":"2013","unstructured":"Machado AM, Desler C, B\u00f8ggild S, Strickertsson JA, Friis-Hansen L, Figueiredo C, Seruca R, Rasmussen LJ (2013) Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. Mech Ageing Dev 134(10):460\u2013466. \n                  https:\/\/doi.org\/10.1016\/j.mad.2013.08.004","journal-title":"Mech Ageing Dev"},{"key":"3_CR85","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0140-6736(02)08025-X","volume":"359","author":"HM Malaty","year":"2002","unstructured":"Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS (2002) Age at acquisition of Helicobacter pylori infection: a follow up study from infancy to adulthood. Lancet 359:931\u2013988. \n                  https:\/\/doi.org\/10.1016\/S0140-6736(02)08025-X","journal-title":"Lancet"},{"issue":"12","key":"3_CR86","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1097\/MEG.0b013e328364b53e","volume":"25","author":"JI Matos","year":"2013","unstructured":"Matos JI, de Sousa HA, Marcos-Pinto R, Dinis-Ribeiro M (2013) Helicobacter pylori CagA and VacA genotypes and gastric phenotype: a meta-analysis. Eur J Gastroenterol Hepatol 25(12):1431\u20131441. \n                  https:\/\/doi.org\/10.1097\/MEG.0b013e328364b53e","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"10","key":"3_CR87","doi-asserted-by":"publisher","first-page":"E316","DOI":"10.3390\/toxins9100316","volume":"9","author":"MS McClain","year":"2017","unstructured":"McClain MS, Beckett AC, Cover TL (2017) Helicobacter pylori vacuolating toxin and gastric cancer. Toxins 9(10):E316. \n                  https:\/\/doi.org\/10.3390\/toxins9100316","journal-title":"Toxins"},{"key":"3_CR88","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nrgastro.2014.143","volume":"11","author":"MH McLean","year":"2014","unstructured":"McLean MH, El-Omar EM (2014) Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol 11:664\u2013674. \n                  https:\/\/doi.org\/10.1038\/nrgastro.2014.143","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3_CR89","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1172\/JCI35073","volume":"118","author":"LB Meira","year":"2008","unstructured":"Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 118:2516\u20132525. \n                  https:\/\/doi.org\/10.1172\/JCI35073","journal-title":"J Clin Invest"},{"key":"3_CR90","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cyto.2017.04.020","volume":"96","author":"JL Melchiades","year":"2017","unstructured":"Melchiades JL, Zabaglia LM, Sallas ML, Orcini WA, Chen E, Smith MAC, Pay\u00e3o SLM, Rasmussen LT (2017) Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori. Cytokine 96:203\u2013207. \n                  https:\/\/doi.org\/10.1016\/j.cyto.2017.04.020","journal-title":"Cytokine"},{"key":"3_CR91","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3748\/wjg.15.1465","volume":"15","author":"HP Melo Barbosa","year":"2009","unstructured":"Melo Barbosa HP, Martins LC, Dos Santos SE, Demachki S, Assump\u00e7\u00e3o MB, Arag\u00e3o CD, de Oliveira Corvelo TC (2009) Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol 15:1465\u20131471","journal-title":"World J Gastroenterol"},{"issue":"8","key":"3_CR92","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1128\/JCM.00551-14","volume":"52","author":"AA Memon","year":"2014","unstructured":"Memon AA, Hussein NR, Miendje Deyi VY, Burette A, Atherton JC (2014) Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study. AJ Clin Microbiol. 52(8):2984\u20132989. \n                  https:\/\/doi.org\/10.1128\/JCM.00551-14","journal-title":"AJ Clin Microbiol."},{"key":"3_CR93","doi-asserted-by":"publisher","first-page":"6305","DOI":"10.3748\/wjg.v11.i40.6305","volume":"11","author":"T Mizuno","year":"2005","unstructured":"Mizuno T, Ando T, Nobata K, Tsuzuki T, Maeda O, Watanabe O, Minami M, Ina K, Kusugami K, Peek RM, Goto H (2005) Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J Gastroenterol 11:6305\u20136311","journal-title":"World J Gastroenterol"},{"key":"3_CR94","doi-asserted-by":"publisher","first-page":"641","DOI":"10.18388\/abp.2015_1045","volume":"62","author":"E Mnich","year":"2015","unstructured":"Mnich E, Gajewski A, Rudnicka K, Gonciarz W, Stawerski P, Hinc K, Obuchowski M, Chmiela M (2015) Immunoregulation of antigen presenting and secretory functions of monocytic cells by Helicobacter pylori antigens in relation to impairment of lymphocyte expansion. Acta Biochim Pol 62:641\u2013650. \n                  https:\/\/doi.org\/10.18388\/abp.2015_1045","journal-title":"Acta Biochim Pol"},{"issue":"8","key":"3_CR95","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1136\/gutjnl-2015-309168","volume":"64","author":"S Mocellin","year":"2015","unstructured":"Mocellin S, Verdi D, Pooley KA, Nitti D (2015) Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. Gut 64(8):1209\u20131219. \n                  https:\/\/doi.org\/10.1136\/gutjnl-2015-309168","journal-title":"Gut"},{"issue":"2","key":"3_CR96","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","volume":"3","author":"SF Moss","year":"2016","unstructured":"Moss SF (2016) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183\u2013191. \n                  https:\/\/doi.org\/10.1016\/j.jcmgh.2016.12.001","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"18","key":"3_CR97","doi-asserted-by":"publisher","first-page":"30937","DOI":"10.1016\/j.abb.2018.12.022","volume":"S0003\u20139861","author":"T Mukherjee","year":"2018","unstructured":"Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE (2018) NOD1 and NOD2 in inflammation, immunity and disease. Arch Biochem Biophys pii S0003\u20139861(18):30937\u201330938. \n                  https:\/\/doi.org\/10.1016\/j.abb.2018.12.022","journal-title":"Arch Biochem Biophys pii"},{"key":"3_CR98","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.tim.2016.12.004","volume":"25","author":"M Naumann","year":"2017","unstructured":"Naumann M, Sokolova O, Tegtmeyer N, Backert S (2017) Helicobacter pylori: a paradigm pathogen for subverting host cell signal transmission. Trends Microbiol 25:316\u2013328. \n                  https:\/\/doi.org\/10.1016\/j.tim.2016.12.004","journal-title":"Trends Microbiol"},{"issue":"3","key":"3_CR99","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1128\/IAI.01226-09","volume":"78","author":"MT Ng","year":"2010","unstructured":"Ng MT, Van\u2019t Hof R, Crockett JC, Hope ME, Berry S, Thomson J, McLean MH, McColl KE, El-Omar EM, Hold GL (2010) Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9\u20131237T\/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun 78(3):1345\u20131352. \n                  https:\/\/doi.org\/10.1128\/IAI.01226-09","journal-title":"Infect Immun"},{"key":"3_CR100","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1089\/dna.2011.1440","volume":"31","author":"P Ni","year":"2012","unstructured":"Ni P, Xu H, Xue H, Lin B, Lu Y (2012) A Meta-analysis on Interleukin-10-1082 promoter polymorphism associated with gastric cancer risk. DNA and Cell Biol 31:582\u2013590. \n                  https:\/\/doi.org\/10.1089\/dna.2011.1440","journal-title":"DNA and Cell Biol"},{"issue":"2","key":"3_CR101","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0002-9440(10)64006-0","volume":"158","author":"C Nogueira","year":"2001","unstructured":"Nogueira C, Figueiredo C, Carneiro F, Gomes AT, Barreira R, Figueira P, Salgado C, Belo L, Peixoto A, Bravo JC, Bravo LE, Realpe JL, Plaisier AP, Quint WG, Ruiz B, Correa P, van Doorn LJ (2001) Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol 158(2):647\u2013654","journal-title":"Am J Pathol"},{"key":"3_CR102","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1128\/JCM.00887-09","volume":"47","author":"H Ogiwara","year":"2009","unstructured":"Ogiwara H, Sugimoto M, Ohno T, Vilaichone RK, Mahachai V, Graham DY, Yamaoka Y (2009) Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases gastroduodenal diseases. J Clin Microbiol 47:3493\u20133500. \n                  https:\/\/doi.org\/10.1128\/JCM.00887-09","journal-title":"J Clin Microbiol"},{"key":"3_CR103","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1136\/gut.2003.033050","volume":"54","author":"M Ohyauchi","year":"2005","unstructured":"Ohyauchi M, Imatani A, Yonechi M, Asano N, Miura A, Iijima K, Koike T, Sekine H, Ohara S, Shimosegawa T (2005) The polymorphism interleukin 8\u2013251 A\/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 54:330\u2013335. \n                  https:\/\/doi.org\/10.1136\/gut.2003.033050","journal-title":"Gut"},{"key":"3_CR104","doi-asserted-by":"publisher","first-page":"e1001069","DOI":"10.1371\/journal.pgen.1001069","volume":"6","author":"P Olbermann","year":"2010","unstructured":"Olbermann P, Josenhans C, Moodley Y, Uhr M, Stamer C, Vauterin M, Suerbaum S, Achtman M, Linz B (2010) A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island. PloS Genet 6:e1001069. \n                  https:\/\/doi.org\/10.1371\/journal.pgen.1001069","journal-title":"PloS Genet"},{"key":"3_CR105","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3390\/biology2031110","volume":"2","author":"M Oleastro","year":"2013","unstructured":"Oleastro M, M\u00e9nard A (2013) The role of Helicobacter pylori outer membrane proteins in adherence and pathogenesis. Biology (Basel) 2:1110\u20131134. \n                  https:\/\/doi.org\/10.3390\/biology2031110","journal-title":"Biology (Basel)"},{"key":"3_CR106","doi-asserted-by":"publisher","first-page":"192420","DOI":"10.1155\/2015\/192420","volume":"2015","author":"SK Pachathundikandi","year":"2015","unstructured":"Pachathundikandi SK, Lind J, Tegtmeyer N, El-Omar EM, Backert S (2015) Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors. Biomed Res Int 2015:192420. \n                  https:\/\/doi.org\/10.1155\/2015\/192420","journal-title":"Biomed Res Int"},{"issue":"1","key":"3_CR107","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cyto.2015.06.017","volume":"76","author":"J Palomo","year":"2015","unstructured":"Palomo J, Dietrich D, Martin P, Palmer G, Gabay C (2015) The interleukin (IL)-1 cytokine family\u2013Balance between agonists and antagonists in inflammatory diseases. Cytokine 76(1):25\u201337. \n                  https:\/\/doi.org\/10.1016\/j.cyto.2015.06.017","journal-title":"Cytokine"},{"key":"3_CR108","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1006\/cimm.2000.1654","volume":"202","author":"B Paziak-Domanska","year":"2000","unstructured":"Paziak-Domanska B, Chmiela M, Jarosi\u0144ska A, Rudnicka W (2000) Potential role of CagA in the inhibition of T cell reactivity in Helicobacter pylori infections. Cell Immunol 202:136\u2013139. \n                  https:\/\/doi.org\/10.1006\/cimm.2000.1654","journal-title":"Cell Immunol"},{"issue":"3","key":"3_CR109","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1158\/1055-9965.EPI-09-0917","volume":"19","author":"B Peleteiro","year":"2010","unstructured":"Peleteiro B, Lunet N, Carrilho C, Dur\u00e3es C, Machado JC, La Vecchia C, Barros H (2010) Association between cytokine gene polymorphisms and gastric precancerous lesions: systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 19(3):762\u2013776. \n                  https:\/\/doi.org\/10.1158\/1055-9965.EPI-09-0917","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"3_CR110","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/aje\/kwq370","volume":"173","author":"C Persson","year":"2011","unstructured":"Persson C, Canedo P, Machado JC, El-Omar EM, Forman D (2011) Polymorphisms in inflammatory response genes and their association with gastric cancer: a HuGE systematic review and meta-analyses. Am J Epidemiol 173(3):259\u2013270. \n                  https:\/\/doi.org\/10.1093\/aje\/kwq370","journal-title":"Am J Epidemiol"},{"key":"3_CR111","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1136\/gutjnl-2016-312779","volume":"67","author":"CP Petersen","year":"2018","unstructured":"Petersen CP, Meyer AR, De Salvo C, Choi E, Schlegel C, Petersen A, Engevik AC, Prasad N, Levy SE, Peebles RS, Pizarro TT, Goldenring JR (2018) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut 67:805\u2013817. \n                  https:\/\/doi.org\/10.1136\/gutjnl-2016-312779","journal-title":"Gut"},{"key":"3_CR112","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s12253-011-9368-9","volume":"17","author":"P Pimentel-Nunes","year":"2011","unstructured":"Pimentel-Nunes P, Afonso L, Lopes P, Roncon-Albuquerque R Jr, Gon\u00e7alves N, Henrique R, Moreira-Dias L, Leite-Moreira AF, Dinis-Ribeiro M (2011) Increased expression of toll-like receptors (TLR) 2, 4, 5 in gastric dysplasia. Pathol Oncol Res 17:677\u2013683. \n                  https:\/\/doi.org\/10.1007\/s12253-011-9368-9","journal-title":"Pathol Oncol Res"},{"key":"3_CR113","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/jnci\/djm120","volume":"99","author":"M Plummer","year":"2007","unstructured":"Plummer M, van Doorn LJ, Franceschi S, Kleter B, Canzian F, Vivas J, Lopez G, Colin D, Mu\u00f1oz N, Kato I (2007) Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 99:1328\u20131334. \n                  https:\/\/doi.org\/10.1093\/jnci\/djm120","journal-title":"J Natl Cancer Inst"},{"key":"3_CR114","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/ijc.28999","volume":"136","author":"M Plummer","year":"2015","unstructured":"Plummer M, Franceschi S, Vignat J, Forman D, de Martel C (2015) Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer 136:487\u2013490. \n                  https:\/\/doi.org\/10.1002\/ijc.28999","journal-title":"Int J Cancer"},{"key":"3_CR115","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1478-811X-11-77","volume":"11","author":"G Posselt","year":"2013","unstructured":"Posselt G, Backert S, Wessler S (2013) The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal 11:77. \n                  https:\/\/doi.org\/10.1186\/1478-811X-11-77","journal-title":"Cell Commun Signal"},{"key":"3_CR116","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.gene.2013.11.007","volume":"537","author":"Z Qinghai","year":"2014","unstructured":"Qinghai Z, Yanying W, Yunfang C, Xukui Z, Xiaoqiao Z (2014) Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in Chinese population. Gene 537:328\u2013332. \n                  https:\/\/doi.org\/10.1016\/j.gene.2013.11.007","journal-title":"Gene"},{"key":"3_CR117","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.clinre.2013.10.011","volume":"38","author":"XP Quin","year":"2014","unstructured":"Quin XP, Zhou Y, Chen Y, Li NN, Wu XT (2014) XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: a meta-analysis. Clin Res Hepatol Gastroenterol 38:226\u2013234. \n                  https:\/\/doi.org\/10.1016\/j.clinre.2013.10.011","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"2","key":"3_CR118","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1086\/376458","volume":"188","author":"R Rad","year":"2003","unstructured":"Rad R, Prinz C, Neu B, Neuhofer M, Zeitner M, Voland P, Becker I, Schepp W, Gerhard M (2003) Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 188(2):272\u2013281. \n                  https:\/\/doi.org\/10.1086\/376458","journal-title":"J Infect Dis"},{"key":"3_CR119","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jmii.2015.03.002","volume":"50","author":"IB Ramis","year":"2015","unstructured":"Ramis IB, Vianna JS, Gon\u00e7alves CV, von Groll A, Dellagostin OA, da Silva PEA (2015) Polymorphisms of the IL-6, IL-8 and IL-10 genes and the risk of gastric pathology in patients infected with Helicobacter pylori. J Microbiol Immunol Infect 50:153\u2013159. \n                  https:\/\/doi.org\/10.1016\/j.jmii.2015.03.002","journal-title":"J Microbiol Immunol Infect"},{"issue":"3","key":"3_CR120","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1053\/j.gastro.2007.06.056","volume":"133","author":"JL Rhead","year":"2007","unstructured":"Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, Eshagh Hosseini M, Atherton JC (2007) A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133(3):926\u2013936. \n                  https:\/\/doi.org\/10.1053\/j.gastro.2007.06.056","journal-title":"Gastroenterology"},{"issue":"7","key":"3_CR121","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1462-5822.2006.00701.x","volume":"8","author":"P Rosenstiel","year":"2006","unstructured":"Rosenstiel P, Hellmig S, Hampe J, Ott S, Till A, Fischbach W, Sahly H, Lucius R, F\u00f6lsch UR, Philpott D, Schreiber S (2006) Influence of polymorphisms in the NOD1\/CARD4 and NOD2\/CARD15 genes on the clinical outcome of Helicobacter pylori infection. Cell Microbiol 8(7):1188\u20131198","journal-title":"Cell Microbiol"},{"key":"3_CR122","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/1753425913518225","volume":"21","author":"K Rudnicka","year":"2015","unstructured":"Rudnicka K, Miszczyk E, Matusiak A, Walencka M, Moran AP, Rudnicka W, Chmiela M (2015) Helicobacter pylori-driven modulation of NK cell expansion, intracellular cytokine expression and cytotoxic activity. Innate Immun 21:127\u2013139. \n                  https:\/\/doi.org\/10.1177\/1753425913518225","journal-title":"Innate Immun"},{"issue":"3","key":"3_CR123","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1158\/1055-9965.EPI-05-0887","volume":"15","author":"SA Savage","year":"2006","unstructured":"Savage SA, Hou L, Lissowska J, Chow WH, Zatonski W, Chanock SJ, Yeager M (2006) Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish population. Cancer Epidemiol Biomarkers Prev 15(3):589\u2013591","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3_CR124","doi-asserted-by":"publisher","first-page":"15217","DOI":"10.1073\/pnas.1009017107","volume":"107","author":"A Sheh","year":"2010","unstructured":"Sheh A, Lee CW, Masumura K, Rickman BH, Nohmi T, Wogan GN, Fox JG, Schauer DB (2010) Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection. Proc Natl Acad Sci USA 107:15217\u201315222. \n                  https:\/\/doi.org\/10.1073\/pnas.1009017107","journal-title":"Proc Natl Acad Sci USA"},{"key":"3_CR125","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1136\/gut.45.1.24","volume":"45","author":"J Shibata","year":"1999","unstructured":"Shibata J, Goto H, Arisawa T, Niwa Y, Hayakawa T, Nakayama A, Mori N (1999) Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection. Gut 45:24\u201331","journal-title":"Gut"},{"issue":"1","key":"3_CR126","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2013.07.034","volume":"340","author":"Y Shigematsu","year":"2013","unstructured":"Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T (2013) Interleukin-1beta induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett 340(1):141\u2013147. \n                  https:\/\/doi.org\/10.1016\/j.canlet.2013.07.034","journal-title":"Cancer Lett"},{"issue":"3","key":"3_CR127","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/ijc.21364","volume":"118","author":"LA Sicinschi","year":"2006","unstructured":"Sicinschi LA, Lopez-Carrillo L, Camargo MC, Correa P, Sierra RA, Henry RR, Chen J, Zabaleta J, Piazuelo MB, Schneider BG (2006) Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int J Cancer 118(3):649\u2013657. \n                  https:\/\/doi.org\/10.1002\/ijc.21364","journal-title":"Int J Cancer"},{"key":"3_CR128","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1469-0691.2009.02811.x","volume":"2010","author":"LA Sicinschi","year":"2010","unstructured":"Sicinschi LA, Correa P, Peek RM, Camargo MC, Piazuelo MB, Romero-Gallo J, Hobbs SS, Krishna U, Delgado A, Mera R, Bravo LE, Schneider BG (2010) CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect 2010:369\u2013378. \n                  https:\/\/doi.org\/10.1111\/j.1469-0691.2009.02811.x","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"3_CR129","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4291\/wjgp.v5.i3.133","volume":"5","author":"SM Smith","year":"2014","unstructured":"Smith SM (2014) Role of Toll-like receptors in Helicobacter pylori infection and immunity. World J Gastrointest Pathophysiol 5(3):133\u2013146. \n                  https:\/\/doi.org\/10.4291\/wjgp.v5.i3.133","journal-title":"World J Gastrointest Pathophysiol"},{"key":"3_CR130","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1371\/journal.pone.0147410","volume":"54","author":"X Sun","year":"2016","unstructured":"Sun X, Xu Y, Wang L, Zhang F, Zhang J, Fu X, Jing T, Han J (2016) Association between TNF A gene polymorphisms and Helicobacter pylori infection: a meta-analysis. PLoS ONE 54:703\u2013706. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0147410","journal-title":"PLoS ONE"},{"key":"3_CR131","doi-asserted-by":"publisher","first-page":"e00389","DOI":"10.1128\/IAI.00389-17","volume":"85","author":"S Tanaka","year":"2017","unstructured":"Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jim\u00e9nez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, Graham DY, Yamaoka Y (2017) Interleukin 17C in human Helicobacter pylori gastritis. InfectImmun 85:e00389\u201317. \n                  https:\/\/doi.org\/10.1128\/IAI.00389-17","journal-title":"InfectImmun"},{"key":"3_CR132","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/0140-6736(93)90938-D","volume":"341","author":"The EUROGAST Study Group","year":"1993","unstructured":"The EUROGAST Study Group (1993) An international association between Helicobacter pylori infection and gastric cancer. Lancet 341:1359\u20131362","journal-title":"Lancet"},{"key":"3_CR133","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3748\/wjg.15.204","volume":"15","author":"LE Torres","year":"2009","unstructured":"Torres LE, Meli\u00e1n K, Moreno A, Alonso J, Sabatier CA, Hern\u00e1ndez M, Berm\u00fadez L, Rodr\u00edguez BL (2009) Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates. World J Gastroenterol 15:204\u2013210","journal-title":"World J Gastroenterol"},{"key":"3_CR134","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1158\/1078-0432.CCR-13-1221","volume":"20","author":"CY Tsai","year":"2014","unstructured":"Tsai CY, Wang CS, Tsai MM, Chi HC, Cheng WL, Tseng YH, Chen CY, Lin CD, Wu JI, Wang LH, Lin KH (2014) Interleukin-32 increases human gastric cancer cell invasion associated with tumor progression and metastasis. Clin Cancer Res 20:2276\u20132288. \n                  https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-1221","journal-title":"Clin Cancer Res"},{"key":"3_CR135","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3390\/ijms18081699","volume":"18","author":"T Tsukamoto","year":"2017","unstructured":"Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X (2017) Prevention of gastric cancer: eradication of Helicobacter pylori and beyond. Int J Mol Sci 18:1699. \n                  https:\/\/doi.org\/10.3390\/ijms18081699","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3_CR136","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","volume":"14","author":"S Tu","year":"2008","unstructured":"Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14(5):408\u2013419. \n                  https:\/\/doi.org\/10.1016\/j.ccr.2008.10.011","journal-title":"Cancer Cell"},{"key":"3_CR137","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-319-50520-6_8","volume":"400","author":"MG Varga","year":"2017","unstructured":"Varga MG, Peek RM (2017) DNA Transfer and Toll-like receptor modulation by Helicobacter pylori. Curr Top Microbiol Immunol 400:169\u2013193. \n                  https:\/\/doi.org\/10.1007\/978-3-319-50520-6_8","journal-title":"Curr Top Microbiol Immunol"},{"key":"3_CR138","doi-asserted-by":"publisher","unstructured":"Vaziri F, Peerayeh SN, Alebouyeh M, Maghsoudi N, Azimzadeh P, Siadat SD, Zali MR (2015) Novel effects of Helicobacter pylori CagA on key genes of gastric cancer signal transduction: a comparative transfection study. Pathog Dis 73(3):ftu021. \n                  https:\/\/doi.org\/10.1093\/femspd\/ftu021","DOI":"10.1093\/femspd\/ftu021"},{"key":"3_CR139","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3748\/wjg.v18.i17.2112","volume":"18","author":"P Wang","year":"2012","unstructured":"Wang P, Zhang L, Jiang JM, Ma D, Tao HX, Yuan SL, Wang YC, Wang LC, Liang H, Zhang ZS, Liu CJ (2012) Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer risk in Chinese population. Worl J Gastroenterol 18:2112\u20132120. \n                  https:\/\/doi.org\/10.3748\/wjg.v18.i17.2112","journal-title":"Worl J Gastroenterol"},{"issue":"6","key":"3_CR140","doi-asserted-by":"publisher","first-page":"e100122","DOI":"10.1371\/journal.pone.0100122","volume":"9","author":"J Wang","year":"2014","unstructured":"Wang J, Guo X, Yu S, Song J, Zhang J, Cao Z, Wang J, Liu M, Dong W (2014) Association between CD14 gene polymorphisms and cancer risk: a meta analysis. PLoS ONE 9(6):e100122. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0100122","journal-title":"PLoS ONE"},{"key":"3_CR141","first-page":"1273","volume":"1","author":"JR Warren","year":"1983","unstructured":"Warren JR, Marshall BJ (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273\u20131275","journal-title":"Lancet"},{"issue":"6","key":"3_CR142","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/infdis\/jiu154","volume":"210","author":"JA Winter","year":"2014","unstructured":"Winter JA, Letley DP, Cook KW, Rhead JL, Zaitoun AA, Ingram RJ, Amilon KR, Croxall NJ, Kaye PV, Robinson K, Atherton JC (2014) A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach. J Infect Dis 210(6):954\u2013963. \n                  https:\/\/doi.org\/10.1093\/infdis\/jiu154","journal-title":"J Infect Dis"},{"key":"3_CR143","doi-asserted-by":"publisher","unstructured":"Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, Lai KC, Hu WH, Yuen ST, Leung SY, Fong DY, Ho J, Ching CK, Chen JS, China Gastric Cancer Study Group (2004) Helicobacter pylori eradication to prevent gastric cancer in a high risk region of China: a randomized controlled trial. JAMA 291:187\u2013194. \n                  https:\/\/doi.org\/10.1001\/jama.291.2.187","DOI":"10.1001\/jama.291.2.187"},{"issue":"5","key":"3_CR144","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/ijc.10987","volume":"104","author":"MS Wu","year":"2003","unstructured":"Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT (2003) Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer 104(5):617\u2013623. \n                  https:\/\/doi.org\/10.1002\/ijc.10987","journal-title":"Int J Cancer"},{"key":"3_CR145","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1038\/onc.2010.352","volume":"29","author":"WK Wu","year":"2010","unstructured":"Wu WK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJ (2010) MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 29:5761\u20135771. \n                  https:\/\/doi.org\/10.1038\/onc.2010.352","journal-title":"Oncogene"},{"key":"3_CR146","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1017\/erm.2013.16","volume":"16","author":"HH Wu","year":"2013","unstructured":"Wu HH, Lin WC, Tsai KW (2013) Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med 16:e1. \n                  https:\/\/doi.org\/10.1017\/erm.2013.16","journal-title":"Expert Rev Mol Med"},{"issue":"1","key":"3_CR147","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.clinre.2016.05.014","volume":"41","author":"Y Xu","year":"2017","unstructured":"Xu Y, Cao X, Jiang J, Chen Y, Wang K (2017) TNF-\u03b1-308\/-238 polymorphisms are associated with gastric cancer: a case-control family study in China. Clin Res Hepatol Gastroenterol 41(1):103\u2013109. \n                  https:\/\/doi.org\/10.1016\/j.clinre.2016.05.014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"3_CR148","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.3748\/wjg.14.4265","volume":"14","author":"Y Yamaoka","year":"2008","unstructured":"Yamaoka Y (2008) Roles of Helicobacter pylori BabA in gastroduodenal pathogenesis. World J Gastroenterol 14:4265\u20134272","journal-title":"World J Gastroenterol"},{"key":"3_CR150","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijmm.2006.11.006","volume":"297","author":"F Ye","year":"2007","unstructured":"Ye F, Brauer T, Niehus E, Drlica K, Josenhans C, Suerbaum S (2007) Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling. Int J Med Microbiol 297:65\u201381. \n                  https:\/\/doi.org\/10.1016\/j.ijmm.2006.11.006","journal-title":"Int J Med Microbiol"},{"key":"3_CR151","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/jcmm.12737","volume":"20","author":"HY Ying","year":"2016","unstructured":"Ying HY, Yu BW, Yang Z, Yang SS, Bo LH, Shan XY, Wang HJ, Zhu YJ, Wu XS (2016) Interleukin-1B 31 C\u2009>\u2009T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies. J Cell Mol Med 20:526\u2013536. \n                  https:\/\/doi.org\/10.1111\/jcmm.12737","journal-title":"J Cell Mol Med"},{"key":"3_CR152","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1136\/jcp.56.4.287","volume":"56","author":"CF Zambon","year":"2003","unstructured":"Zambon CF, Navaglia F, Basso D, Rugge M, Plebani M (2003) Helicobacter pylori babA2, cagA, and s1 vacA genes work synergistically in causing intestinal metaplasia. J Clin Pathol 56:287\u2013291","journal-title":"J Clin Pathol"},{"key":"3_CR153","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cyto.2004.10.013","volume":"29","author":"CF Zambon","year":"2005","unstructured":"Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, Greco E, Gallo N, Rugge M, Di Mario F, Plebani M (2005) Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine 29:141\u2013152. \n                  https:\/\/doi.org\/10.1016\/j.cyto.2004.10.013","journal-title":"Cytokine"},{"key":"3_CR154","doi-asserted-by":"publisher","first-page":"e1004621","DOI":"10.1371\/journal.ppat.1004621","volume":"11","author":"XS Zhang","year":"2015","unstructured":"Zhang XS, Tegtmeyer N, Traube L, Jindal S, Perez-Perez G, Sticht H, Backert S, Blaser MJ (2015) A specific A\/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interaction. PLoS Pathog 11:e1004621. \n                  https:\/\/doi.org\/10.1371\/journal.ppat.1004621","journal-title":"PLoS Pathog"},{"key":"3_CR155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2017.04.038","volume":"623","author":"JZ Zhang","year":"2017","unstructured":"Zhang JZ, Liu CM, Peng HP, Zhang Y (2017) Association of genetic variations in IL-6\/IL6R pathway genes with gastric cancer risk in a Chinese population. Gene 623:1\u20134. \n                  https:\/\/doi.org\/10.1016\/j.gene.2017.04.038","journal-title":"Gene"},{"key":"3_CR156","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.7314\/APJCP.2014.15.6.2863","volume":"15","author":"F Zhao","year":"2014","unstructured":"Zhao F, Zhu H, Huang M, Yi C, Huang Y (2014) The 765 G\u2009>\u2009C polymorphism in the cyclooxygenase-2 gene and gastric cancer risk: an update by meta-analysis. Asian Pac J Cancer Prev 15:2863\u20132868","journal-title":"Asian Pac J Cancer Prev"},{"key":"3_CR157","doi-asserted-by":"publisher","first-page":"e109605","DOI":"10.1371\/journal.pone.0109605","volume":"9","author":"Q Zhou","year":"2014","unstructured":"Zhou Q, Wang C, Wang X, Wu X, Zhu Z, Liu B, Su L (2014) Association between TLR4 (+896A\/G and +1196C\/T) polymorphisms and gastric cancer risk: an updated meta-analysis. PLoS ONE 9:e109605. \n                  https:\/\/doi.org\/10.1371\/journal.pone.0109605","journal-title":"PLoS ONE"}],"container-title":["Current Topics in Microbiology and Immunology","Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-15138-6_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T22:08:35Z","timestamp":1558649315000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-15138-6_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030151379","9783030151386"],"references-count":154,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-15138-6_3","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"24 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}