{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T14:33:37Z","timestamp":1742913217770,"version":"3.40.3"},"publisher-location":"Cham","reference-count":23,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030159498"},{"type":"electronic","value":"9783030159504"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-15950-4_12","type":"book-chapter","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:02:52Z","timestamp":1564059772000},"page":"225-236","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sequence Variant and Posttranslational Modification Analysis During Cell Line Selection via High-Throughput Peptide Mapping"],"prefix":"10.1007","author":[{"given":"Chong-Feng","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pete","family":"Bryngelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Sosic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"12_CR1","volume-title":"Biologics global market opportunities and strategies to 2021 Market Watch","author":"Clare","year":"2018","unstructured":"Clare. (2018). Biologics global market opportunities and strategies to 2021 Market Watch. Philadelphia, PA: The Business Research Company."},{"issue":"3","key":"12_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/btpr.2263","volume":"32","author":"C Wright","year":"2016","unstructured":"Wright, C., Groot, J., Swahn, S., McLaughlin, H., Liu, M., Xu, C., et al. (2016). Genetic mutation analysis at early stages of cell line development using next generation sequencing. Biotechnology Progress, 32(3), 5.","journal-title":"Biotechnology Progress"},{"issue":"1","key":"12_CR3","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.biotechadv.2017.10.006","volume":"36","author":"HE Wong","year":"2018","unstructured":"Wong, H. E., Huang, C. J., & Zhang, Z. (2018). Amino acid misincorporation in recombinant proteins. Biotechnology Advances, 36(1), 168\u2013181.","journal-title":"Biotechnology Advances"},{"issue":"45","key":"12_CR4","doi-asserted-by":"publisher","first-page":"8165","DOI":"10.1021\/bi401002c","volume":"52","author":"Z Zhang","year":"2013","unstructured":"Zhang, Z., Shah, B., & Bondarenko, P. V. (2013). G\/U and certain wobble position mismatches as possible main causes of amino acid misincorporations. Biochemistry, 52(45), 8165\u20138176.","journal-title":"Biochemistry"},{"issue":"47","key":"12_CR5","doi-asserted-by":"publisher","first-page":"32686","DOI":"10.1074\/jbc.M109.059360","volume":"284","author":"D Wen","year":"2009","unstructured":"Wen, D., Vecchi, M. M., Gu, S., Su, L., Dolnikova, J., Huang, Y. M., et al. (2009). Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells. The Journal of Biological Chemistry, 284(47), 32686\u201332694.","journal-title":"The Journal of Biological Chemistry"},{"issue":"22","key":"12_CR6","doi-asserted-by":"publisher","first-page":"9282","DOI":"10.1021\/ac901541h","volume":"81","author":"XC Yu","year":"2009","unstructured":"Yu, X. C., Borisov, O. V., Alvarez, M., Michels, D. A., Wang, Y. J., Ling, V., et al. (2009). Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry. Analytical Chemistry, 81(22), 9282\u20139290.","journal-title":"Analytical Chemistry"},{"issue":"13","key":"12_CR7","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1007\/s00216-015-8618-1","volume":"407","author":"LJ Brady","year":"2015","unstructured":"Brady, L. J., Scott, R. A., & Balland, A. (2015). An optimized approach to the rapid assessment and detection of sequence variants in recombinant protein products. Analytical and Bioanalytical Chemistry, 407(13), 3851\u20133860.","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"3","key":"12_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4161\/mabs.2.3.11718","volume":"2","author":"Y Yang","year":"2010","unstructured":"Yang, Y., Strahan, A., Li, C., Shen, A., Liu, H., Ouyang, J., et al. (2010). Detecting low level sequence variants in recombinant monoclonal antibodies. MAbs, 2(3), 285\u2013298.","journal-title":"MAbs"},{"key":"12_CR9","doi-asserted-by":"crossref","unstructured":"Scott, R. A., Rogers, R., Balland, A. & Brady, L. J. (2014). Rapid identification of an antibody DNA construct rearrangement sequence variant by mass spectrometry. MAbs, 6(6), 1453\u20131463.","DOI":"10.4161\/mabs.36222"},{"key":"12_CR10","doi-asserted-by":"crossref","unstructured":"Zhang, T., Huang, Y., Chamberlain, S., Romeo, T., Zhu-Shimoni, J., Hewitt, D., et al. (2012). Identification of a single base-pair mutation of TAA (Stop codon) --> GAA (Glu) that causes light chain extension in a CHO cell derived IgG1. MAbs, 4(6), 694\u2013700.","DOI":"10.4161\/mabs.22232"},{"issue":"7","key":"12_CR11","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nrm3383","volume":"13","author":"KW Moremen","year":"2012","unstructured":"Moremen, K. W., Tiemeyer, M., & Nairn, A. V. (2012). Vertebrate protein glycosylation: Diversity, synthesis and function. Nature Reviews. Molecular Cell Biology, 13(7), 448\u2013462.","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"12_CR12","first-page":"187","volume":"127","author":"P Hossler","year":"2012","unstructured":"Hossler, P. (2012). Protein glycosylation control in mammalian cell culture: Past precedents and contemporary prospects. Advances in Biochemical Engineering\/Biotechnology, 127, 187\u2013219.","journal-title":"Advances in Biochemical Engineering\/Biotechnology"},{"issue":"7","key":"12_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/glycob\/cwr027","volume":"21","author":"AM Goetze","year":"2011","unstructured":"Goetze, A. M., Liu, Y. D., Zhang, Z., Shah, B., Lee, E., Bondarenko, P. V., et al. (2011). High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans. Glycobiology, 21(7), 949\u2013959.","journal-title":"Glycobiology"},{"issue":"4","key":"12_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4161\/mabs.20737","volume":"4","author":"M Yu","year":"2012","unstructured":"Yu, M., Brown, D., Reed, C., Chung, S., Lutman, J., Stefanich, E., et al. (2012). Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans. MAbs, 4(4), 475\u2013487.","journal-title":"MAbs"},{"key":"12_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ab.2013.11.020","volume":"448","author":"JM Yang","year":"2014","unstructured":"Yang, J. M., Ai, J., Bao, Y., Yuan, Z., Qin, Y., Xie, Y. W., et al. (2014). Investigation of the correlation between charge and glycosylation of IgG1 variants by liquid chromatography-mass spectrometry. Analytical Biochemistry, 448, 82\u201391.","journal-title":"Analytical Biochemistry"},{"key":"12_CR16","doi-asserted-by":"crossref","unstructured":"Dick Jr., L. W., Kim, C., Qiu, D. & Cheng, K. C. (2007). Determination of the origin of the N-terminal pyro-glutamate variation in monoclonal antibodies using model peptides. Biotechnology and Bioengineering, 97(3), 544\u2013553.","DOI":"10.1002\/bit.21260"},{"key":"12_CR17","doi-asserted-by":"crossref","unstructured":"Assarsson, A., Hellstrand, E., Cabaleiro-Lago, C. & Linse, S. (2014). Charge dependent retardation of amyloid beta aggregation by hydrophilic proteins. ACS Chemical Neuroscience, 5(4), 266\u2013274.","DOI":"10.1021\/cn400124r"},{"issue":"5","key":"12_CR18","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1365-2141.2006.06488.x","volume":"136","author":"B Kaplan","year":"2007","unstructured":"Kaplan, B., Livneh, A., & Gallo, G. (2007). Charge differences between in vivo deposits in immunoglobulin light chain amyloidosis and non-amyloid light chain deposition disease. British Journal of Haematology, 136(5), 723\u2013728.","journal-title":"British Journal of Haematology"},{"issue":"2","key":"12_CR19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jmb.2011.05.046","volume":"411","author":"K Levitan","year":"2011","unstructured":"Levitan, K., Chereau, D., Cohen, S. I., Knowles, T. P., Dobson, C.M., Fink, A. L., et al. (2011). Conserved C-terminal charge exerts a profound influence on the aggregation rate of alpha-synuclein. Journal of Molecular Biology, 411(2), 329\u2013333.","journal-title":"Journal of Molecular Biology"},{"key":"12_CR20","doi-asserted-by":"crossref","unstructured":"Berkowitz, S. A., Engen, J. R., Mazzeo, J. R., & Jones, G. B. (2012). Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nature Reviews. Drug Discovery, 11(7), 527\u2013540.","DOI":"10.1038\/nrd3746"},{"issue":"2","key":"12_CR21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1080\/19420862.2015.1116658","volume":"8","author":"Z Lian","year":"2016","unstructured":"Lian, Z., Wu, Q., & Wang, T. (2016). Identification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cells. MAbs, 8(2), 358\u2013370.","journal-title":"MAbs"},{"issue":"8","key":"12_CR22","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1080\/19420862.2017.1366395","volume":"9","author":"F Griaud","year":"2017","unstructured":"Griaud, F., Winter, A., Denefeld, B., Lang, M., Hensinger, H., Straube, F., et al. (2017). Identification of multiple serine to asparagine sequence variation sites in an intended copy product of LUCENTIS(R) by mass spectrometry. MAbs, 9(8), 1337\u20131348.","journal-title":"MAbs"},{"issue":"6","key":"12_CR23","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1080\/19420862.2017.1336591","volume":"9","author":"W Li","year":"2017","unstructured":"Li, W., Wypych, J., & Duff, R. J. (2017). Improved sequence variant analysis strategy by automated false positive removal. MAbs, 9(6), 978\u2013984.","journal-title":"MAbs"}],"container-title":["Advances in Experimental Medicine and Biology","Advancements of Mass Spectrometry in Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-15950-4_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T17:20:29Z","timestamp":1580923229000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-15950-4_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030159498","9783030159504"],"references-count":23,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-15950-4_12","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"26 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}