{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:32:32Z","timestamp":1791844352341,"version":"4.3.4"},"publisher-location":"Cham","reference-count":51,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030216368","type":"print"},{"value":"9783030217358","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-21735-8_3","type":"book-chapter","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T17:03:27Z","timestamp":1569603807000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface"],"prefix":"10.1007","author":[{"given":"Darlene A.","family":"Dartt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,28]]},"reference":[{"issue":"3","key":"3_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","volume":"37","author":"DW DelMonte","year":"2011","unstructured":"DelMonte DW, Kim T (2011) Anatomy and physiology of the cornea. J Cataract Refract Surg 37(3):588\u2013598","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"3_CR2","first-page":"421","volume":"13","author":"R Ramphal","year":"1981","unstructured":"Ramphal R, McNiece MT, Polack FM (1981) Adherence of Pseudomonas aeruginosa to the injured cornea: a step in the pathogenesis of corneal infections. Ann Ophthalmol 13(4):421\u2013425","journal-title":"Ann Ophthalmol"},{"issue":"11","key":"3_CR3","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nri1224","volume":"3","author":"JW Streilein","year":"2003","unstructured":"Streilein JW (2003) Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 3(11):879\u2013889","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"3_CR4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","volume":"21","author":"DA Dartt","year":"2002","unstructured":"Dartt DA (2002) Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Retin Eye Res 21(6):555\u2013576","journal-title":"Prog Retin Eye Res"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","volume":"231","author":"IK Gipson","year":"2003","unstructured":"Gipson IK, Argueso P (2003) Role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol 231:1\u201349","journal-title":"Int Rev Cytol"},{"issue":"5","key":"3_CR6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/ACI.0b013e32830e6b04","volume":"8","author":"F Mantelli","year":"2008","unstructured":"Mantelli F, Argueso P (2008) Functions of ocular surface mucins in health and disease. Curr Opin Allergy Clin Immunol 8(5):477\u2013483","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"8","key":"3_CR7","doi-asserted-by":"publisher","first-page":"e72304","DOI":"10.1371\/journal.pone.0072304","volume":"8","author":"J Mauris","year":"2013","unstructured":"Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi CR, Panjwani N et al (2013) Modulation of ocular surface glycocalyx barrier function by a galectin-3 N-terminal deletion mutant and membrane-anchored synthetic glycopolymers. PLoS One 8(8):e72304","journal-title":"PLoS One"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.exer.2013.07.027","volume":"117","author":"RR Hodges","year":"2013","unstructured":"Hodges RR, Dartt DA (2013) Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res 117:62\u201378","journal-title":"Exp Eye Res"},{"issue":"3","key":"3_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1469-7580.2005.00394.x","volume":"206","author":"E Knop","year":"2005","unstructured":"Knop E, Knop N (2005) The role of eye-associated lymphoid tissue in corneal immune protection. J Anat 206(3):271\u2013285","journal-title":"J Anat"},{"issue":"3","key":"3_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10384-010-0804-2","volume":"54","author":"S Kinoshita","year":"2010","unstructured":"Kinoshita S, Ueta M (2010) Innate immunity of the ocular surface. Jpn J Ophthalmol 54(3):194\u2013198","journal-title":"Jpn J Ophthalmol"},{"issue":"1","key":"3_CR11","doi-asserted-by":"publisher","first-page":"e000101","DOI":"10.1136\/bmjophth-2017-000101","volume":"2","author":"D Li","year":"2017","unstructured":"Li D, Hodges RR, Bispo P, Gilmore MS, Gregory-Ksander M, Dartt DA (2017) Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ Open Ophthalmol 2(1):e000101","journal-title":"BMJ Open Ophthalmol"},{"issue":"9","key":"3_CR12","doi-asserted-by":"publisher","first-page":"e74010","DOI":"10.1371\/journal.pone.0074010","volume":"8","author":"VE McGilligan","year":"2013","unstructured":"McGilligan VE, Gregory-Ksander MS, Li D, Moore JE, Hodges RR, Gilmore MS et al (2013) Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS One 8(9):e74010","journal-title":"PLoS One"},{"issue":"5","key":"3_CR13","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3390\/ijms18050978","volume":"18","author":"FL Barbosa","year":"2017","unstructured":"Barbosa FL, Xiao Y, Bian F, Coursey TG, Ko BY, Clevers H et al (2017) Goblet cells contribute to ocular surface immune tolerance-implications for dry eye disease. Int J Mol Sci 18(5):978","journal-title":"Int J Mol Sci"},{"key":"3_CR14","doi-asserted-by":"crossref","unstructured":"Baudouin C, Rolando M, Benitez Del Castillo JM, Messmer EM, Figueiredo FC, Irkec M et al (2018) Reconsidering the central role of mucins in dry eye and ocular surface diseases. Prog Retin Eye Res. 2018, In Press.","DOI":"10.1016\/j.preteyeres.2018.11.007"},{"issue":"5","key":"3_CR15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/ACI.0000000000000098","volume":"14","author":"DA Dartt","year":"2014","unstructured":"Dartt DA, Masli S (2014) Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol 14(5):464\u2013470","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"1","key":"3_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1006\/exer.1996.0088","volume":"63","author":"DA Dartt","year":"1996","unstructured":"Dartt DA, Kessler TL, Chung EH, Zieske JD (1996) Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells. Exp Eye Res 63(1):27\u201334","journal-title":"Exp Eye Res"},{"issue":"11","key":"3_CR17","doi-asserted-by":"publisher","first-page":"993","DOI":"10.3109\/02713689508998520","volume":"14","author":"DA Dartt","year":"1995","unstructured":"Dartt DA, McCarthy DM, Mercer HJ, Kessler TL, Chung EH, Zieske JD (1995) Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res 14(11):993\u20131000","journal-title":"Curr Eye Res"},{"issue":"11","key":"3_CR18","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3109\/02713689508998519","volume":"14","author":"TL Kessler","year":"1995","unstructured":"Kessler TL, Mercer HJ, Zieske JD, McCarthy DM, Dartt DA (1995) Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva. Curr Eye Res 14(11):985\u2013992","journal-title":"Curr Eye Res"},{"issue":"2","key":"3_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.preteyeres.2008.01.001","volume":"27","author":"OA Candia","year":"2008","unstructured":"Candia OA, Alvarez LJ (2008) Fluid transport phenomena in ocular epithelia. Prog Retin Eye Res 27(2):197\u2013212","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"3_CR20","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.exer.2007.11.021","volume":"86","author":"OA Candia","year":"2008","unstructured":"Candia OA, Kong CW, Alvarez LJ (2008) IBMX-elicited inhibition of water permeability in the isolated rabbit conjunctival epithelium. Exp Eye Res 86(3):480\u2013491","journal-title":"Exp Eye Res"},{"issue":"6","key":"3_CR21","first-page":"1102","volume":"40","author":"JD Rios","year":"1999","unstructured":"Rios JD, Zoukhri D, Rawe IM, Hodges RR, Zieske JD, Dartt DA (1999) Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion. Invest Ophthalmol Vis Sci 40(6):1102\u20131111","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"3_CR22","doi-asserted-by":"publisher","first-page":"C988","DOI":"10.1152\/ajpcell.00582.2001","volume":"284","author":"H Kanno","year":"2003","unstructured":"Kanno H, Horikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD et al (2003) Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol 284(4):C988\u2013C998","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3_CR23","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1167\/iovs.12-11264","volume":"54","author":"D Li","year":"2013","unstructured":"Li D, Jiao J, Shatos MA, Hodges RR, Dartt DA (2013) Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1\/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci 54(4):2872\u20132884","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"3_CR24","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pharmthera.2008.11.006","volume":"121","author":"L Dickson","year":"2009","unstructured":"Dickson L, Finlayson K (2009) VPAC and PAC receptors: from ligands to function. Pharmacol Ther 121(3):294\u2013316","journal-title":"Pharmacol Ther"},{"issue":"2","key":"3_CR25","doi-asserted-by":"publisher","first-page":"C236","DOI":"10.1152\/ajpcell.00077.2018","volume":"315","author":"DG Puro","year":"2018","unstructured":"Puro DG (2018) Role of ion channels in the functional response of conjunctival goblet cells to dry eye. Am J Physiol Cell Physiol 315(2):C236\u2013CC46","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7503","key":"3_CR26","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","volume":"510","author":"CN Serhan","year":"2014","unstructured":"Serhan CN (2014) Pro-resolving lipid mediators are leads for resolution physiology. Nature 510(7503):92\u2013101","journal-title":"Nature"},{"issue":"3","key":"3_CR27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0014-4835(83)90121-5","volume":"36","author":"RN Williams","year":"1983","unstructured":"Williams RN, Bhattacherjee P, Eakins KE (1983) Biosynthesis of lipoxygenase products by ocular tissues. Exp Eye Res 36(3):397\u2013402","journal-title":"Exp Eye Res"},{"key":"3_CR28","first-page":"39","volume":"312","author":"PS Kulkarni","year":"1989","unstructured":"Kulkarni PS, Srinivasan BD (1989) Cyclooxygenase and lipoxygenase pathways in anterior uvea and conjunctiva. Prog Clin Biol Res 312:39\u201352","journal-title":"Prog Clin Biol Res"},{"issue":"4","key":"3_CR29","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1089\/jop.1987.3.349","volume":"3","author":"PS Kulkarni","year":"1987","unstructured":"Kulkarni PS, Kaufman PL, Srinivasan BD (1987) Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3(4):349\u2013356","journal-title":"J Ocul Pharmacol"},{"issue":"6","key":"3_CR30","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1038\/s41385-018-0070-z","volume":"11","author":"Y Gao","year":"2018","unstructured":"Gao Y, Su J, Zhang Y, Chan A, Sin JH, Wu D et al (2018) Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease. Mucosal Immunol 11(6):1674\u20131683","journal-title":"Mucosal Immunol"},{"issue":"7","key":"3_CR31","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.4049\/jimmunol.1500610","volume":"195","author":"Y Gao","year":"2015","unstructured":"Gao Y, Min K, Zhang Y, Su J, Greenwood M, Gronert K (2015) Female-specific downregulation of tissue polymorphonuclear neutrophils drives impaired regulatory T cell and amplified effector T cell responses in autoimmune dry eye disease. J Immunol 195(7):3086\u20133099","journal-title":"J Immunol"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2017.03.006","volume":"58","author":"J Wei","year":"2017","unstructured":"Wei J, Gronert K (2017) The role of pro-resolving lipid mediators in ocular diseases. Mol Asp Med 58:37\u201343","journal-title":"Mol Asp Med"},{"issue":"17","key":"3_CR33","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1073\/pnas.81.17.5335","volume":"81","author":"CN Serhan","year":"1984","unstructured":"Serhan CN, Hamberg M, Samuelsson B (1984) Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci U S A 81(17):5335\u20135339","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3_CR34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/MOL.0000000000000262","volume":"27","author":"AE Barden","year":"2016","unstructured":"Barden AE, Mas E, Mori TA (2016) n-3 fatty acid supplementation and proresolving mediators of inflammation. Curr Opin Lipidol 27(1):26\u201332","journal-title":"Curr Opin Lipidol"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1476-511X-12-89","volume":"12","author":"GA Weiss","year":"2013","unstructured":"Weiss GA, Troxler H, Klinke G, Rogler D, Braegger C, Hersberger M (2013) High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. Lipids Health Dis 12:89","journal-title":"Lipids Health Dis"},{"issue":"3","key":"3_CR36","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/mi.2015.99","volume":"9","author":"H Arnardottir","year":"2016","unstructured":"Arnardottir H, Orr SK, Dalli J, Serhan CN (2016) Human milk proresolving mediators stimulate resolution of acute inflammation. Mucosal Immunol 9(3):757\u2013766","journal-title":"Mucosal Immunol"},{"issue":"10","key":"3_CR37","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1373\/clinchem.2012.190199","volume":"58","author":"E Mas","year":"2012","unstructured":"Mas E, Croft KD, Zahra P, Barden A, Mori TA (2012) Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. Clin Chem 58(10):1476\u20131484","journal-title":"Clin Chem"},{"issue":"1","key":"3_CR38","doi-asserted-by":"publisher","first-page":"C39","DOI":"10.1152\/ajpcell.00024.2014","volume":"307","author":"RA Colas","year":"2014","unstructured":"Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN (2014) Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol 307(1):C39\u2013C54","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3_CR39","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1007\/s12035-015-9544-0","volume":"53","author":"M Zhu","year":"2016","unstructured":"Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm AC et al (2016) Pro-resolving lipid mediators improve neuronal survival and increase Abeta42 phagocytosis. Mol Neurobiol 53(4):2733\u20132749","journal-title":"Mol Neurobiol"},{"issue":"22","key":"3_CR40","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1073\/pnas.0402531101","volume":"101","author":"PK Mukherjee","year":"2004","unstructured":"Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A 101(22):8491\u20138496","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.plefa.2017.01.004","volume":"117","author":"JT English","year":"2017","unstructured":"English JT, Norris PC, Hodges RR, Dartt DA, Serhan CN (2017) Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics. Prostaglandins Leukot Essent Fat Acids 117:17\u201327","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"2","key":"3_CR42","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1476-5381.2011.01345.x","volume":"164","author":"JF Lima-Garcia","year":"2011","unstructured":"Lima-Garcia JF, Dutra RC, da Silva K, Motta EM, Campos MM, Calixto JB (2011) The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. Br J Pharmacol 164(2):278\u2013293","journal-title":"Br J Pharmacol"},{"issue":"6","key":"3_CR43","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1167\/iovs.16-19131","volume":"57","author":"SD Walter","year":"2016","unstructured":"Walter SD, Gronert K, McClellan AL, Levitt RC, Sarantopoulos KD, Galor A (2016) omega-3 tear film lipids correlate with clinical measures of dry eye. Invest Ophthalmol Vis Sci 57(6):2472\u20132478","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"3_CR44","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1080\/02713683.2016.1255338","volume":"42","author":"S Masoudi","year":"2017","unstructured":"Masoudi S, Zhao Z, Willcox M (2017) Relation between ocular comfort, arachidonic acid mediators, and histamine. Curr Eye Res 42(6):822\u2013826","journal-title":"Curr Eye Res"},{"issue":"6","key":"3_CR45","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/mi.2013.7","volume":"6","author":"D Li","year":"2013","unstructured":"Li D, Hodges RR, Jiao J, Carozza RB, Shatos MA, Chiang N et al (2013) Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol 6(6):1119\u20131130","journal-title":"Mucosal Immunol"},{"issue":"7","key":"3_CR46","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","volume":"186","author":"DA Dartt","year":"2011","unstructured":"Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CN (2011) Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol 186(7):4455\u20134466","journal-title":"J Immunol"},{"issue":"11","key":"3_CR47","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1167\/iovs.17-21914","volume":"58","author":"M Lippestad","year":"2017","unstructured":"Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA (2017) Resolvin D1 increases mucin secretion in cultured rat conjunctival goblet cells via multiple signaling pathways. Invest Ophthalmol Vis Sci 58(11):4530\u20134544","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3_CR48","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/mi.2016.33","volume":"10","author":"RR Hodges","year":"2017","unstructured":"Hodges RR, Li D, Shatos MA, Bair JA, Lippestad M, Serhan CN et al (2017) Lipoxin A4 activates ALX\/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal Immunol 10(1):46\u201357","journal-title":"Mucosal Immunol"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"36124","DOI":"10.1038\/srep36124","volume":"6","author":"RR Hodges","year":"2016","unstructured":"Hodges RR, Li D, Shatos MA, Serhan CN, Dartt DA (2016) Lipoxin A4 counter-regulates histamine-stimulated glycoconjugate secretion in conjunctival goblet cells. Sci Rep 6:36124","journal-title":"Sci Rep"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-1-4615-5359-5_26","volume":"438","author":"D Zoukhri","year":"1998","unstructured":"Zoukhri D, Hodges RR, Sergheraert C, Dartt DA (1998) Protein kinase C isoforms differentially control lacrimal gland functions. Adv Exp Med Biol 438:181\u2013186","journal-title":"Adv Exp Med Biol"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.exer.2018.11.018","volume":"180","author":"R Kaye","year":"2018","unstructured":"Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP et al (2018) Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells. Exp Eye Res 180:53\u201362","journal-title":"Exp Eye Res"}],"container-title":["Advances in Experimental Medicine and Biology","The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-21735-8_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T17:05:39Z","timestamp":1569603939000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-21735-8_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030216368","9783030217358"],"references-count":51,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-21735-8_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"28 September 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}