{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:20:10Z","timestamp":1792272010890,"version":"4.4.0"},"publisher-location":"Cham","reference-count":16,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030273774","type":"print"},{"value":"9783030273781","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-27378-1_1","type":"book-chapter","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T18:02:49Z","timestamp":1577556169000},"page":"3-7","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["AMD-Associated HTRA1 Variants Do Not Influence TGF-\u03b2 Signaling in Microglia"],"prefix":"10.1007","author":[{"given":"Isha","family":"Akhtar-Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Reuten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Langmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"1_CR1","doi-asserted-by":"crossref","unstructured":"Akhtar-Schafer I, Wang L, Krohne TU et al (2018) Modulation of three key innate immune pathways for the most common retinal degenerative diseases. EMBO Mol Med","DOI":"10.15252\/emmm.201708259"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12974-015-0296-6","volume":"12","author":"A Aslanidis","year":"2015","unstructured":"Aslanidis A, Karlstetter M, Scholz R et al (2015) Activated microglia\/macrophage whey acidic protein (AMWAP) inhibits NFkappaB signaling and induces a neuroprotective phenotype in microglia. J Neuroinflammation 12:77","journal-title":"J Neuroinflammation"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"6361","DOI":"10.1093\/hmg\/ddv346","volume":"24","author":"U Friedrich","year":"2015","unstructured":"Friedrich U, Datta S, Schubert T et al (2015) Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-beta signaling. Hum Mol Genet 24:6361","journal-title":"Hum Mol Genet"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1016\/j.molimm.2007.01.004","volume":"44","author":"A Gilicze","year":"2007","unstructured":"Gilicze A, Kohalmi B, Pocza P et al (2007) HtrA1 is a novel mast cell serine protease of mice and men. Mol Immunol 44:2961\u20132968","journal-title":"Mol Immunol"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/cr.2008.326","volume":"19","author":"MJ Goumans","year":"2009","unstructured":"Goumans MJ, Liu Z, ten Dijke P (2009) TGF-beta signaling in vascular biology and dysfunction. Cell Res 19:116\u2013127","journal-title":"Cell Res"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1128\/MCB.01283-12","volume":"33","author":"SM Jacobo","year":"2013","unstructured":"Jacobo SM, Deangelis MM, Kim IK et al (2013) Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol 33:1976\u20131990","journal-title":"Mol Cell Biol"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1038\/s41598-018-20733-2","volume":"8","author":"MH Madeira","year":"2018","unstructured":"Madeira MH, Rashid K, Ambrosio AF et al (2018) Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. Sci Rep 8:2272","journal-title":"Sci Rep"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1167\/iovs.14-14453","volume":"55","author":"M Nakayama","year":"2014","unstructured":"Nakayama M, Iejima D, Akahori M et al (2014) Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. Invest Ophthalmol Vis Sci 55:6514\u20136523","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152386","volume":"11","author":"R Reuten","year":"2016","unstructured":"Reuten R, Nikodemus D, Oliveira MB et al (2016) Maltose-Binding Protein (MBP), a secretion-enhancing tag for mammalian protein expression systems. PLoS One 11:e0152386","journal-title":"PLoS One"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12974-015-0431-4","volume":"12","author":"R Scholz","year":"2015","unstructured":"Scholz R, Sobotka M, Caramoy A et al (2015) Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation 12:209","journal-title":"J Neuroinflammation"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1167\/iovs.16-20922","volume":"58","author":"GM Tosi","year":"2017","unstructured":"Tosi GM, Caldi E, Neri G et al (2017) HTRA1 and TGF-beta1 concentrations in the aqueous humor of patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 58:162\u2013167","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/j.ophtha.2008.05.021","volume":"115","author":"J Tuo","year":"2008","unstructured":"Tuo J, Ross RJ, Reed GF et al (2008) The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology 115:1891\u20131898","journal-title":"Ophthalmology"},{"key":"1_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022959","volume":"6","author":"S Vierkotten","year":"2011","unstructured":"Vierkotten S, Muether PS, Fauser S (2011) Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components. PLoS One 6:e22959","journal-title":"PLoS One"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1126\/science.1133811","volume":"314","author":"Z Yang","year":"2006","unstructured":"Yang Z, Camp NJ, Sun H et al (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (New York, NY) 314:992\u2013993","journal-title":"Science (New York, NY)"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000099259","volume":"92","author":"P Zamiri","year":"2007","unstructured":"Zamiri P, Sugita S, Streilein JW (2007) Immunosuppressive properties of the pigmented epithelial cells and the subretinal space. Chem Immunol Allergy 92:86\u201393","journal-title":"Chem Immunol Allergy"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1038\/s41467-018-06224-y","volume":"9","author":"T Z\u00f6ller","year":"2018","unstructured":"Z\u00f6ller T, Schneider A, Kleimeyer C et al (2018) Silencing of TGF\u03b2 signalling in microglia results in impaired homeostasis. Nat Commun 9:4011","journal-title":"Nat Commun"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-27378-1_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T09:08:25Z","timestamp":1586423305000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-27378-1_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030273774","9783030273781"],"references-count":16,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-27378-1_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"29 December 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}