{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:33:08Z","timestamp":1758123188201,"version":"3.40.3"},"publisher-location":"Cham","reference-count":38,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030273774"},{"type":"electronic","value":"9783030273781"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/978-3-030-27378-1_47","type":"book-chapter","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T18:02:49Z","timestamp":1577556169000},"page":"289-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lipid Signaling in Retinal Pigment Epithelium Cells Exposed to Inflammatory and Oxidative Stress Conditions. Molecular Mechanisms Underlying Degenerative Retinal Diseases"],"prefix":"10.1007","author":[{"given":"Vicente","family":"Berm\u00fadez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula E.","family":"Tenconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma M.","family":"Giusto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina V.","family":"Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"47_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-3-319-17121-0_18","volume":"854","author":"MP Agbaga","year":"2016","unstructured":"Agbaga MP (2016) Different mutations in ELOVL4 affect very long chain fatty acid biosynthesis to cause variable neurological disorders in humans. Adv Exp Med Biol 854:129\u2013135","journal-title":"Adv Exp Med Biol"},{"key":"47_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-1-4615-3426-6_25","volume":"318","author":"RE Anderson","year":"1992","unstructured":"Anderson RE, O\u2019Brien PJ, Wiegand RD et al (1992) Conservation of docosahexaenoic acid in the retina. Adv Exp Med Biol 318:285\u2013294","journal-title":"Adv Exp Med Biol"},{"key":"47_CR3","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1074\/jbc.R117.783076","volume":"292","author":"A Asatryan","year":"2017","unstructured":"Asatryan A, Bazan NG (2017) Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. J Biol Chem 292:12390\u201312397","journal-title":"J Biol Chem"},{"key":"47_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/0-387-32442-9_74","volume":"572","author":"NG Bazan","year":"2006","unstructured":"Bazan NG (2006) Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv Exp Med Biol 572:531\u2013540","journal-title":"Adv Exp Med Biol"},{"key":"47_CR5","doi-asserted-by":"publisher","first-page":"4866","DOI":"10.1167\/iovs.07-0918","volume":"48","author":"NG Bazan","year":"2007","unstructured":"Bazan NG (2007) Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. Invest Ophthalmol Vis Sci 48:4866\u20134881","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"47_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev.nutr.012809.104635","volume":"31","author":"NG Bazan","year":"2011","unstructured":"Bazan NG, Molina MF, Gordon WC (2011) Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer\u2019s, and other neurodegenerative diseases. Annu Rev Nutr 31:321\u2013351","journal-title":"Annu Rev Nutr"},{"key":"47_CR38","doi-asserted-by":"crossref","unstructured":"Berm\u00fadez V, Tenconi PE, Giusto NM, Mateos MV (2019) Lipopolysaccharide-induced autophagy mediates retinal pigment epithelium cells survival. Modulation by the phospholipase D pathway. Front Cell Neurosci 13:154","DOI":"10.3389\/fncel.2019.00154"},{"key":"47_CR7","first-page":"3331","volume":"42","author":"PS Bernstein","year":"2001","unstructured":"Bernstein PS, Tammur J, Singh N et al (2001) Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene. Invest Ophthalmol Vis Sci 42:3331\u20133336","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"47_CR8","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.bbalip.2009.02.007","volume":"1791","author":"DN Brindley","year":"2009","unstructured":"Brindley DN, Pilquil C, Sariahmetoglu M et al (2009) Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Biochim Biophys Acta 1791:956\u2013961","journal-title":"Biochim Biophys Acta"},{"key":"47_CR9","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nrd.2016.252","volume":"16","author":"HA Brown","year":"2017","unstructured":"Brown HA, Thomas PG, Lindsley CW (2017) Targeting phospholipase D in cancer, infection and neurodegenerative disorders. Nat Rev Drug Discov 16:351\u2013367","journal-title":"Nat Rev Drug Discov"},{"key":"47_CR10","first-page":"283","volume":"15","author":"AJ Carr","year":"2009","unstructured":"Carr AJ, Vugler A, Lawrence J et\u00a0al (2009) Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay. Mol Vis 15:283\u2013295","journal-title":"Mol Vis"},{"key":"47_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tibs.2006.11.004","volume":"32","author":"S Carrasco","year":"2007","unstructured":"Carrasco S, Merida I (2007) Diacylglycerol, when simplicity becomes complex. Trends Biochem Sci 32:27\u201336","journal-title":"Trends Biochem Sci"},{"key":"47_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tips.2015.01.001","volume":"36","author":"MA Frohman","year":"2015","unstructured":"Frohman MA (2015) The phospholipase D superfamily as therapeutic targets. Trends Pharmacol Sci 36:137\u2013144","journal-title":"Trends Pharmacol Sci"},{"key":"47_CR13","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.1038\/s41598-017-05433-7","volume":"7","author":"B Jun","year":"2017","unstructured":"Jun B, Mukherjee PK, Asatryan A et al (2017) Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity. Sci Rep 7:5279","journal-title":"Sci Rep"},{"key":"47_CR14","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","volume":"73","author":"A Kauppinen","year":"2016","unstructured":"Kauppinen A, Paterno JJ, Blasiak J et\u00a0al (2016) Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci 73:1765\u20131786","journal-title":"Cell Mol Life Sci"},{"key":"47_CR15","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1167\/iovs.06-0865","volume":"48","author":"M Kolko","year":"2007","unstructured":"Kolko M, Wang J, Zhan C et al (2007) Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci 48:1401\u20131409","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"47_CR16","first-page":"511","volume":"20","author":"M Kolko","year":"2014","unstructured":"Kolko M, Vohra R, Westlund van der Burght B et al (2014) Calcium-independent phospholipase A(2), group VIA, is critical for RPE cell survival. Mol Vis 20:511\u2013521","journal-title":"Mol Vis"},{"key":"47_CR17","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/jcp.22756","volume":"227","author":"SK Lim","year":"2012","unstructured":"Lim SK, Park MJ, Lim JC et al (2012) Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells. J Cell Physiol 227:569\u2013577","journal-title":"J Cell Physiol"},{"key":"47_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.biocel.2014.08.016","volume":"55","author":"MV Mateos","year":"2014","unstructured":"Mateos MV, Kamerbeek CB, Giusto NM et al (2014) The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium. Int J Biochem Cell Biol 55:119\u2013128","journal-title":"Int J Biochem Cell Biol"},{"key":"47_CR19","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1167\/iovs.04-0078","volume":"45","author":"A Maugeri","year":"2004","unstructured":"Maugeri A, Meire F, Hoyng CB et al (2004) A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy. Invest Ophthalmol Vis Sci 45:4263\u20134267","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"47_CR20","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nrn3811","volume":"15","author":"R Mechoulam","year":"2014","unstructured":"Mechoulam R, Hanus LO, Pertwee R et al (2014) Early phytocannabinoid chemistry to endocannabinoids and beyond. Nat Rev Neurosci 15:757\u2013764","journal-title":"Nat Rev Neurosci"},{"key":"47_CR21","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1073\/pnas.0402531101","volume":"101","author":"PK Mukherjee","year":"2004","unstructured":"Mukherjee PK, Marcheselli VL, Serhan CN et al (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A 101:8491\u20138496","journal-title":"Proc Natl Acad Sci U S A"},{"key":"47_CR22","doi-asserted-by":"publisher","first-page":"13158","DOI":"10.1073\/pnas.0705963104","volume":"104","author":"PK Mukherjee","year":"2007","unstructured":"Mukherjee PK, Marcheselli VL, de Rivero Vaccari JC et al (2007) Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc Natl Acad Sci U S A 104:13158\u201313163","journal-title":"Proc Natl Acad Sci U S A"},{"key":"47_CR23","doi-asserted-by":"publisher","first-page":"E395","DOI":"10.1152\/ajpendo.00477.2009","volume":"298","author":"AC Newton","year":"2010","unstructured":"Newton AC (2010) Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab 298:E395\u2013E402","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"47_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1748-1716.2011.02298.x","volume":"204","author":"X Peng","year":"2012","unstructured":"Peng X, Frohman MA (2012) Mammalian phospholipase D physiological and pathological roles. Acta Physiol (Oxf) 204:219\u2013226","journal-title":"Acta Physiol (Oxf)"},{"key":"47_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.it.2015.04.003","volume":"36","author":"VL Perez","year":"2015","unstructured":"Perez VL, Caspi RR (2015) Immune mechanisms in inflammatory and degenerative eye disease. Trends Immunol 36:354\u2013363","journal-title":"Trends Immunol"},{"key":"47_CR26","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1038\/ncomms7228","volume":"6","author":"DS Rice","year":"2015","unstructured":"Rice DS, Calandria JM, Gordon WC et al (2015) Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun 6:6228","journal-title":"Nat Commun"},{"key":"47_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2916732","volume":"2016","author":"T Schwitzer","year":"2016","unstructured":"Schwitzer T, Schwan R, Angioi-Duprez K et al (2016) The endocannabinoid system in the retina: from physiology to practical and therapeutic applications. Neural Plast 2016:2916732","journal-title":"Neural Plast"},{"key":"47_CR28","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","volume":"85","author":"O Strauss","year":"2005","unstructured":"Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85:845\u2013881","journal-title":"Physiol Rev"},{"key":"47_CR29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ejphar.2016.03.066","volume":"787","author":"O Strauss","year":"2016","unstructured":"Strauss O (2016) Pharmacology of the retinal pigment epithelium, the interface between retina and body system. Eur J Pharmacol 787:84\u201393","journal-title":"Eur J Pharmacol"},{"key":"47_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jare.2017.11.004","volume":"11","author":"H Tallima","year":"2018","unstructured":"Tallima H, El Ridi R (2018) Arachidonic acid: physiological roles and potential health benefits\u00a0\u2013 a review. J Adv Res 11:33\u201341","journal-title":"J Adv Res"},{"key":"47_CR31","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1194\/jlr.R058362","volume":"56","author":"X Tang","year":"2015","unstructured":"Tang X, Benesch MG, Brindley DN (2015) Lipid phosphate phosphatases and their roles in mammalian physiology and pathology. J Lipid Res 56:2048\u20132060","journal-title":"J Lipid Res"},{"key":"47_CR32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biocel.2016.10.015","volume":"81","author":"PE Tenconi","year":"2016","unstructured":"Tenconi PE, Giusto NM, Salvador GA et al (2016) Phospholipase D1 modulates protein kinase C-epsilon in retinal pigment epithelium cells during inflammatory response. Int J Biochem Cell Biol 81:67\u201375","journal-title":"Int J Biochem Cell Biol"},{"key":"47_CR33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jbior.2017.10.009","volume":"67","author":"AM Vasquez","year":"2018","unstructured":"Vasquez AM, Mouchlis VD, Dennis EA (2018) Review of four major distinct types of human phospholipase A2. Adv Biol Regul 67:212\u2013218","journal-title":"Adv Biol Regul"},{"key":"47_CR34","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tips.2006.04.003","volume":"27","author":"QJ Wang","year":"2006","unstructured":"Wang QJ (2006) PKD at the crossroads of DAG and PKC signaling. Trends Pharmacol Sci 27:317\u2013323","journal-title":"Trends Pharmacol Sci"},{"key":"47_CR35","first-page":"1243","volume":"15","author":"Y Wei","year":"2009","unstructured":"Wei Y, Wang X, Wang L (2009) Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. Mol Vis 15:1243\u20131251","journal-title":"Mol Vis"},{"key":"47_CR36","first-page":"357","volume":"19","author":"Y Wei","year":"2013","unstructured":"Wei Y, Wang X, Zhao F et al (2013) Cannabinoid receptor 1 blockade protects human retinal pigment epithelial cells from oxidative injury. Mol Vis 19:357\u2013366","journal-title":"Mol Vis"},{"key":"47_CR37","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nrm2335","volume":"9","author":"MP Wymann","year":"2008","unstructured":"Wymann MP, Schneiter R (2008) Lipid signalling in disease. Nat Rev Mol Cell Biol 9:162\u2013176","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-27378-1_47","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T09:10:39Z","timestamp":1586423439000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-27378-1_47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030273774","9783030273781"],"references-count":38,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-27378-1_47","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"29 December 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}