{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:34:31Z","timestamp":1742963671111,"version":"3.40.3"},"publisher-location":"Cham","reference-count":63,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030306502"},{"type":"electronic","value":"9783030306519"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-30651-9_12","type":"book-chapter","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T06:04:14Z","timestamp":1581055454000},"page":"243-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Arginine and Its Deprivation on Human Glioblastoma Physiology and Signaling"],"prefix":"10.1007","author":[{"given":"Olena","family":"Karatsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleh","family":"Stasyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jolanta","family":"Redowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,8]]},"reference":[{"key":"12_CR1","volume-title":"Molecular biology of the cell","author":"B Alberts","year":"2008","unstructured":"Alberts B, Johnson A, Lewis J, Roberts K, Walter P (2008) Molecular biology of the cell, 5th edn. Garland Science, New York","edition":"5"},{"key":"12_CR2","doi-asserted-by":"publisher","first-page":"12096","DOI":"10.1038\/s41598-018-30591-7","volume":"8","author":"C Alexandrou","year":"2018","unstructured":"Alexandrou C, Al-Aqbi SS, Higgins JA, Boyle W, Karmokar A, Andreadi C, Luo JL, Moore DA, Viskaduraki M, Blades M, Murray G, Howells LM, Thomas A, Brown K, Cheng PN, Rufini A (2018) Sensitivity of colorectal Cancer to arginine deprivation therapy is shaped by differential expression of urea cycle enzymes. Sci Rep 8:12096. \nhttps:\/\/doi.org\/10.1038\/s41598-018-30591-7","journal-title":"Sci Rep"},{"key":"12_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jbior.2015.09.008","volume":"60","author":"C Azevedo","year":"2016","unstructured":"Azevedo C, Saiardi A (2016) Why always lysine? The ongoing tale of one of the most modified amino acids. Adv Biol Regul 60:144\u2013150. \nhttps:\/\/doi.org\/10.1016\/j.jbior.2015.09.008","journal-title":"Adv Biol Regul"},{"key":"12_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2014.06.005","volume":"79-80","author":"G Benton","year":"2014","unstructured":"Benton G, Arnaoutova I, George J, Kleinman HK, Koblinski J (2014) Matrigel: from discovery and ECM mimicry to assays and models for cancer research. Adv Drug Deliv Rev 79-80:3\u201318. \nhttps:\/\/doi.org\/10.1016\/j.addr.2014.06.005","journal-title":"Adv Drug Deliv Rev"},{"key":"12_CR5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1152\/physrev.00018.2013","volume":"94","author":"L Blanchoin","year":"2014","unstructured":"Blanchoin L, Boujemaa-Paterski R, Sykes C, Plastino J (2014) Actin dynamics, architecture, and mechanics in cell motility. Physiol Rev 94:235\u2013263. \nhttps:\/\/doi.org\/10.1152\/physrev.00018.2013","journal-title":"Physiol Rev"},{"key":"12_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.biocel.2015.10.027","volume":"70","author":"Y Bobak","year":"2016","unstructured":"Bobak Y, Kurlishchuk Y, Vynnytska-Myronovska B, Grydzuk O, Shuvayeva G, Redowicz MJ, Kunz-Schughart LA, Stasyk O (2016) Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells. Int J Biochem Cell Biol 70:29\u201338. \nhttps:\/\/doi.org\/10.1016\/j.biocel.2015.10.027","journal-title":"Int J Biochem Cell Biol"},{"key":"12_CR7","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1042\/CBI20100451","volume":"34","author":"YP Bobak","year":"2010","unstructured":"Bobak YP, Vynnytska BO, Kurlishchuk YV, Sibirny AA, Stasyk OV (2010) Cancer cell sensitivity to arginine deprivation in vitro is not determined by endogenous levels of arginine metabolic enzymes. Cell Biol Int 34:1085\u20131089. \nhttps:\/\/doi.org\/10.1042\/CBI20100451","journal-title":"Cell Biol Int"},{"key":"12_CR8","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1091\/mbc.10.11.3745","volume":"10","author":"K Burton","year":"1999","unstructured":"Burton K, Park JH, Taylor DL (1999) Keratocytes generate traction forces in two phases. Mol Biol Cell 10:3745\u20133769. \nhttps:\/\/doi.org\/10.1091\/mbc.10.11.3745","journal-title":"Mol Biol Cell"},{"key":"12_CR9","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/s42003-018-0178-4","volume":"1","author":"CT Cheng","year":"2018","unstructured":"Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK (2018) Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol 1:178. \nhttps:\/\/doi.org\/10.1038\/s42003-018-0178-4","journal-title":"Commun Biol"},{"key":"12_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.83","volume":"3","author":"B Delage","year":"2012","unstructured":"Delage B, Luong P, Maharaj L, O\u2019Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li CF, Joel S, Fitzgibbon J, Chen LT, Szlosarek PW (2012) Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. Cell Death Dis 3:e342. \nhttps:\/\/doi.org\/10.1038\/cddis.2012.83","journal-title":"Cell Death Dis"},{"key":"12_CR11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/13543776.2018.1508452","volume":"28","author":"R Dhankhar","year":"2018","unstructured":"Dhankhar R, Gulati P, Kumar S, Kapoor RK (2018) Arginine-lowering enzymes againstcancer: a technocommercial analysis through patent landscape. Expert Opin Ther Pat 28:603\u2013614. \nhttps:\/\/doi.org\/10.1080\/13543776.2018.1508452","journal-title":"Expert Opin Ther Pat"},{"key":"12_CR12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1007\/s40265-018-0978-3","volume":"78","author":"S Dhillon","year":"2018","unstructured":"Dhillon S (2018) Ivosidenib: first global approval. Drugs 78:1509\u20131516. \nhttps:\/\/doi.org\/10.1007\/s40265-018-0978-3","journal-title":"Drugs"},{"key":"12_CR13","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/15384047.2015.1026478","volume":"16","author":"T Fiedler","year":"2015","unstructured":"Fiedler T, Strauss M, Hering S, Redanz U, William D, Rosche Y, Classen CF, Kreikemeyer B, Linnebacher M, Maletzki C (2015) Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo. Cancer Biol Ther 16:1047\u20131055. \nhttps:\/\/doi.org\/10.1080\/15384047.2015.1026478","journal-title":"Cancer Biol Ther"},{"key":"12_CR14","doi-asserted-by":"publisher","first-page":"4854","DOI":"10.1038\/nature08908","volume":"463","author":"DA Fletcher","year":"2010","unstructured":"Fletcher DA, Mullins RD (2010) Cell mechanics and the cytoskeleton. Nature 463:4854\u20134892. \nhttps:\/\/doi.org\/10.1038\/nature08908","journal-title":"Nature"},{"key":"12_CR15","doi-asserted-by":"publisher","unstructured":"Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, Cho YJ, Pingle SC, Crawford JR, Piccioni DE, Kesari S (2015) Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction. Oncotarget 6: 1157-1170. Doi: \nhttps:\/\/doi.org\/10.18632\/oncotarget.2708","DOI":"10.18632\/oncotarget.2708"},{"issue":"11","key":"12_CR16","doi-asserted-by":"publisher","first-page":"19271","DOI":"10.1002\/jcp.28563","volume":"234","author":"Abdolmajid Ghasemian","year":"2019","unstructured":"Ghasemian A, Al-Marzoqi AH, Al-Abodi HR, Alghanimi YK, Kadhum SA, Shokouhi Mostafavi SK, Fattahi A (2019) Bacterial l-asparaginases for cancer therapy: current knowledge and future perspectives. J Cell Physiol (Apr 16). \nhttps:\/\/doi.org\/10.1002\/jcp.28563\n\n. [Epub ahead of print]","journal-title":"Journal of Cellular Physiology"},{"key":"12_CR17","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1158\/1078-0432.CCR-18-3729","volume":"25","author":"PE Hall","year":"2019","unstructured":"Hall PE, Lewis R, Syed N, Shaffer R, Evanson J, Ellis S, Williams M, Feng X, Johnston A, Thomson JA, Harris FP, Jena R, Matys T, Jefferies S, Smith K, Wu BW, Bomalaski JS, Crook T, O\u2019Neill K, Paraskevopoulos D, Khadeir RS, Sheaff M, Pacey S, Plowman PN, Szlosarek PW (2019) A phase I study of Pegylated arginine deiminase (Pegargiminase), cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-deficient recurrent high-grade glioma. Clin Cancer Res 25:2708\u20132716. \nhttps:\/\/doi.org\/10.1158\/1078-0432.CCR-18-3729","journal-title":"Clin Cancer Res"},{"key":"12_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev.nutr.23.011702.073120","volume":"24","author":"M Hatzoglou","year":"2004","unstructured":"Hatzoglou M, Fernandez J, Yaman I (2004) Regulation of cationic amino acid transport: the story of the CAT-1 transporter. Annu Rev Nutr 24:377\u2013399. \nhttps:\/\/doi.org\/10.1146\/annurev.nutr.23.011702.073120","journal-title":"Annu Rev Nutr"},{"key":"12_CR19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1158\/1535-7163.MCT-16-0807","volume":"17","author":"CN Hinrichs","year":"2018","unstructured":"Hinrichs CN, Ingargiola M, K\u00e4ubler T, L\u00f6ck S, Temme A, K\u00f6hn-Luque A, Deutsch A, Vovk O, Stasyk O, Kunz-Schughart LA (2018) Arginine deprivation therapy: putative strategy to eradicate glioblastoma cells by Radiosensitization. Mol Cancer Ther 17:393\u2013406. \nhttps:\/\/doi.org\/10.1158\/1535-7163.MCT-16-0807","journal-title":"Mol Cancer Ther"},{"key":"12_CR21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41467-018-03066-6","volume":"9","author":"K Jungnickel","year":"2018","unstructured":"Jungnickel K, Parker JL, Newstead S (2018) Structural basis for amino acid transport by the CAT family of SLC7 transporters. Nat Commun 9:550. \nhttps:\/\/doi.org\/10.1038\/s41467-018-03066-6","journal-title":"Nat Commun"},{"key":"12_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1126\/science.1129344","volume":"313","author":"M Karakozova","year":"2006","unstructured":"Karakozova M, Kozak M, Wong CC, Bailey AO, Yates JR 3rd, Mogilner A, Zebroski H, Kashina A (2006) Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science 313:192\u2013196. \nhttps:\/\/doi.org\/10.1126\/science.1129344","journal-title":"Science"},{"key":"12_CR23","doi-asserted-by":"publisher","unstructured":"Karpel-Massler G, Ramani D, Shu C, Halatsch ME, Westhoff MA, Bruce JN, Canoll P, Siegelin MD (2016) Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo. Oncotarget 7:33512\u201333528. \nhttps:\/\/doi.org\/10.18632\/oncotarget.9257","DOI":"10.18632\/oncotarget.9257"},{"key":"12_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11060-014-1698-5","volume":"122","author":"O Khoury","year":"2015","unstructured":"Khoury O, Ghazale N, Stone E, El-Sibai M, Frankel AE, Abi-Habib RJ (2015) Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells. J Neuro-Oncol 122:75\u201385. \nhttps:\/\/doi.org\/10.1007\/s11060-014-1698-5","journal-title":"J Neuro-Oncol"},{"key":"12_CR25","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/S0142-9612(99)00205-7","volume":"21","author":"S Kouvroukoglou","year":"2000","unstructured":"Kouvroukoglou S, Dee KC, Bizios R, McIntire LV, Zygourakis K (2000) Endothelial cell migration on surfaces modified with immobilized adhesive peptides. Biomaterials 21:1725\u20131733. \nhttps:\/\/doi.org\/10.1016\/S0142-9612(99)00205-7","journal-title":"Biomaterials"},{"key":"12_CR26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.yjmcc.2012.05.007","volume":"53","author":"S Kurosaka","year":"2012","unstructured":"Kurosaka S, Leu NA, Pavlov I, Han X, Ribeiro PA, Xu T, Bunte R, Saha S, Wang J, Cornachione A, Mai W, Yates JR 3rd, Rassier DE, Kashina A (2012) Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy. J Mol Cell Cardiol 53:333\u2013341. \nhttps:\/\/doi.org\/10.1016\/j.yjmcc.2012.05.007","journal-title":"J Mol Cell Cardiol"},{"key":"12_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13045-017-0509-9","volume":"10","author":"M Kwong","year":"2017","unstructured":"Kwong M, Fung L, Chi-Fung Chan G (2017) Drug-induced amino acid deprivation as strategy for cancer therapy. J Hematol Oncol 10:144. \nhttps:\/\/doi.org\/10.1186\/s13045-017-0509-9","journal-title":"J Hematol Oncol"},{"key":"12_CR28","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1073\/pnas.71.7.2803","volume":"71","author":"AM Lengsfeld","year":"1974","unstructured":"Lengsfeld AM, L\u00f6w I, Wieland T, Dancker P, Hasselbach W (1974) Interaction of phalloidin with actin. Proc Natl Acad Sci U S A 71:2803\u20132807. \nhttps:\/\/doi.org\/10.1073\/pnas.71.7.2803","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/07357907.2017.1292517","volume":"35","author":"Z Li","year":"2017","unstructured":"Li Z, Chang CM, Wang L, Zhang P, Shu HG (2017a) Cyclooxygenase-2 induction by amino acid deprivation requires p38 mitogen-activated protein kinase in human glioma cells. Cancer Investig 35:237\u2013247. \nhttps:\/\/doi.org\/10.1080\/07357907.2017.1292517","journal-title":"Cancer Investig"},{"key":"12_CR30","doi-asserted-by":"publisher","first-page":"894","DOI":"10.5137\/1019-5149.JTN.17746-16.1","volume":"27","author":"H Li","year":"2017","unstructured":"Li H, Lei B, Xiang W, Wang H, Feng W, Liu Y, Qi S (2017b) Differences in protein expression between the U251 and U87 cell lines. Turk Neurosurg 27:894\u2013903. \nhttps:\/\/doi.org\/10.5137\/1019-5149.JTN.17746-16.1","journal-title":"Turk Neurosurg"},{"key":"12_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.bbcan.2018.01.004","volume":"1869","author":"CJ Libby","year":"2018","unstructured":"Libby CJ, Tran AN, Scott SE, Griguer C, Hjelmeland AB (2018) The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells. Biochim Biophys Acta Rev Cancer 1869:175\u2013188. \nhttps:\/\/doi.org\/10.1016\/j.bbcan.2018.01.004","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"12_CR32","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1007\/s11064-017-2212-1","volume":"42","author":"J M\u00e1rquez","year":"2017","unstructured":"M\u00e1rquez J, Alonso FJ, Mat\u00e9s JM, Segura JA, Mart\u00edn-Rufi\u00e1n M, Campos-Sandoval JA (2017) Glutamine addiction in gliomas. Neurochem Res 42:1735\u20131746. \nhttps:\/\/doi.org\/10.1007\/s11064-017-2212-1","journal-title":"Neurochem Res"},{"key":"12_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00726-016-2342-9","volume":"49","author":"A Maus","year":"2017","unstructured":"Maus A, Peters GJ (2017) Glutamate and \u03b1-ketoglutarate: key players in glioma metabolism. Amino Acids 49:21\u201332. \nhttps:\/\/doi.org\/10.1007\/s00726-016-2342-9","journal-title":"Amino Acids"},{"key":"12_CR34","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12885-018-4040-3","volume":"18","author":"L M\u00f6r\u00e9n","year":"2018","unstructured":"M\u00f6r\u00e9n L, Perryman R, Crook T, Langer JK, Oneill K, Syed N, Antti H (2018) Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM. BMC Cancer 18:167. \nhttps:\/\/doi.org\/10.1186\/s12885-018-4040-3","journal-title":"BMC Cancer"},{"key":"12_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.nutr.22.110801.140547","volume":"22","author":"SM Morris","year":"2002","unstructured":"Morris SM (2002) Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev Nutr 22:87\u2013105. \nhttps:\/\/doi.org\/10.1146\/annurev.nutr.22.110801.140547","journal-title":"Annu Rev Nutr"},{"key":"12_CR36","doi-asserted-by":"publisher","first-page":"2743S","DOI":"10.1093\/jn\/134.10.2743S","volume":"134","author":"SM Morris","year":"2004","unstructured":"Morris SM (2004) Enzymes of arginine metabolism. J Nutr 134:2743S\u20132747S. \nhttps:\/\/doi.org\/10.1093\/jn\/134.10.2743S","journal-title":"J Nutr"},{"key":"12_CR37","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1158\/1541-7786.MCR-13-0576","volume":"12","author":"EH Panosyan","year":"2014","unstructured":"Panosyan EH, Wang Y, Xia P, Lee WN, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI, Lasky JL 3rd (2014) Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res 12:694\u2013702. \nhttps:\/\/doi.org\/10.1158\/1541-7786.MCR-13-0576","journal-title":"Mol Cancer Res"},{"key":"12_CR38","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/tra.12551","volume":"19","author":"I Pavlyk","year":"2018","unstructured":"Pavlyk I, Leu NA, Vedula P, Kurosaka S, Kashina A (2018) Rapid and dynamic arginylation of the leading edge \u03b2-actin is required for cell migration. Traffic 19:263\u2013272. \nhttps:\/\/doi.org\/10.1111\/tra.12551","journal-title":"Traffic"},{"key":"12_CR39","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-014-1857-1","volume":"47","author":"I Pavlyk","year":"2015","unstructured":"Pavlyk I, Rzhepetskyy Y, Jagielski AK, Drozak J, Wasik A, Pereverzieva G, Olchowik M, Kunz-Schugart LA, Stasyk O, Redowicz MJ (2015) Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of \u03b2-actin arginylation. Amino Acids 47:199\u2013212. \nhttps:\/\/doi.org\/10.1007\/s00726-014-1857-1","journal-title":"Amino Acids"},{"key":"12_CR40","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/s41419-018-1195-4","volume":"9","author":"JM Przystal","year":"2018","unstructured":"Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O\u2019Neill K, Crook T, Syed N (2018) Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM. Cell Death Dis 9:1192. \nhttps:\/\/doi.org\/10.1038\/s41419-018-1195-4","journal-title":"Cell Death Dis"},{"key":"12_CR41","doi-asserted-by":"publisher","first-page":"10123","DOI":"10.1073\/pnas.0504500102","volume":"102","author":"R Rai","year":"2005","unstructured":"Rai R, Kashina A (2005) Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. Proc Natl Acad Sci U S A 102:10123\u201310128. \nhttps:\/\/doi.org\/10.1073\/pnas.0504500102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR42","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1159\/000495382","volume":"51","author":"C Riess","year":"2018","unstructured":"Riess C, Shokraie F, Classen CF, Kreikemeyer B, Fiedler T, Junghanss C, Maletzki C (2018) Arginine-depleting enzymes - an increasingly recognized treatment strategy for therapy-refractory malignancies. Cell Physiol Biochem 51:854\u2013870. \nhttps:\/\/doi.org\/10.1159\/000495382","journal-title":"Cell Physiol Biochem"},{"key":"12_CR43","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/ar.23958","volume":"301","author":"A Rodriguez","year":"2018","unstructured":"Rodriguez A, Kashina A (2018) Posttranscriptional and posttranslational regulation of actin. Anat Rec (Hoboken) 301:1991\u20131998. \nhttps:\/\/doi.org\/10.1002\/ar.23958","journal-title":"Anat Rec (Hoboken)"},{"key":"12_CR44","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/bies.950120702","volume":"12","author":"PA Rubenstein","year":"1990","unstructured":"Rubenstein PA (1990) The functional importance of multiple actin isoforms. BioEssays 12:309\u2013315. \nhttps:\/\/doi.org\/10.1002\/bies.950120702","journal-title":"BioEssays"},{"key":"12_CR47","doi-asserted-by":"publisher","unstructured":"Sanghez V, Chen M, Li S, Chou TF, Iacovino M, Lin HJ, Lasky JL, Panosyan EH (2018) Efficacy of Asparaginase Erwinia chrysanthemi with and without Temozolomide against glioma cells and intracranial mouse Medulloblastoma. Anticancer Res 38:2627\u20132634. \nhttps:\/\/doi.org\/10.21873\/anticanres.12504","DOI":"10.21873\/anticanres.12504"},{"key":"12_CR48","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.canlet.2014.07.015","volume":"356","author":"TN Seyfried","year":"2015","unstructured":"Seyfried TN, Flores R, Poff AM, D\u2019Agostino DP, Mukherjee P (2015) Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Lett 356:289\u2013300. \nhttps:\/\/doi.org\/10.1016\/j.canlet.2014.07.015","journal-title":"Cancer Lett"},{"key":"12_CR50","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/cbin.10383","volume":"39","author":"O Stasyk","year":"2015","unstructured":"Stasyk O, Boretsky Y, Gonchar M, Sibirny A (2015) Recombinant arginine-degrading enzymes in metabolic anticancer therapy and bioanalytics. Cell Biol Int 39:246\u2013252. \nhttps:\/\/doi.org\/10.1002\/cbin.10383","journal-title":"Cell Biol Int"},{"key":"12_CR51","first-page":"4499","volume":"26","author":"J Styczynski","year":"2006","unstructured":"Styczynski J, Olszewska-Slonina D, Kolodziej B, Napieraj M, Wysocki M (2006) Activity of bortezomib in glioblastoma. Anticancer Res 26:4499\u20134503","journal-title":"Anticancer Res"},{"key":"12_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/505041","volume":"2014","author":"Galyna Shuvayeva","year":"2014","unstructured":"Shuvayeva G, Bobak Y, Igumentseva N, Titone R, Morani F, Stasyk O, Isidoro C (2014) Single amino acid arginine deprivation triggers prosurvival autophagic response in ovarian carcinoma SKOV3. Biomed Res Int 505041. \nhttps:\/\/doi.org\/10.1155\/2014\/505041","journal-title":"BioMed Research International"},{"key":"12_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.197","volume":"4","author":"N Syed","year":"2013","unstructured":"Syed N, Langer J, Janczar K, Singh P, Lo Nigro C, Lattanzio L, Coley HM, Hatzimichael E, Bomalaski J, Szlosarek P, Awad M, O\u2019Neil K, Roncaroli F, Crook T (2013) Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis 4:e458. \nhttps:\/\/doi.org\/10.1038\/cddis.2012.197","journal-title":"Cell Death Dis"},{"key":"12_CR54","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.advms.2018.08.018","volume":"64","author":"J Szefela","year":"2019","unstructured":"Szefela J, Danielak A, Kruszewska WJ (2019) Metabolic pathways of L-arginine and therapeutic consequences in tumors. Adv Med Sci 64:104\u2013110. \nhttps:\/\/doi.org\/10.1016\/j.advms.2018.08.018","journal-title":"Adv Med Sci"},{"key":"12_CR55","doi-asserted-by":"publisher","first-page":"7126","DOI":"10.1158\/1078-0432.CCR-06-1101","volume":"12","author":"PW Szlosarek","year":"2006","unstructured":"Szlosarek PW, Klabatsa A, Pallaska A, Sheaff M, Smith P, Crook T, Grimshaw MJ, Steele JP, Rudd RM, Balkwill FR, Fennell DA (2006) In vivo loss of expression of Argininosuccinate Synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res 12:7126\u20137131. \nhttps:\/\/doi.org\/10.1158\/1078-0432.CCR-06-1101","journal-title":"Clin Cancer Res"},{"key":"12_CR56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ceb.2012.10.009","volume":"25","author":"JR Terman","year":"2013","unstructured":"Terman JR, Kashina A (2013) Post-translational modification and regulation of actin. Curr Opin Cell Biol 25:30\u201338. \nhttps:\/\/doi.org\/10.1016\/j.ceb.2012.10.009","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"12_CR57","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3390\/ijms18061175","volume":"18","author":"Angkana Thongkum","year":"2017","unstructured":"Thongkum A, Wu C, Li YY, Wangpaichitr M, Navasumrit P, Parnlob V, Sricharunrat T, Bhudhisawasdi V, Ruchirawat M, Savaraj N (2017) The combination of arginine deprivation and 5-fluorouracil improves therapeutic efficacy in argininosuccinate synthetase negative hepatocellular carcinoma. Int J Mol Sci 18. pii: E1175. \nhttps:\/\/doi.org\/10.3390\/ijms18061175","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"12_CR58","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/nm.3217","volume":"19","author":"Martje T\u00f6njes","year":"2013","unstructured":"T\u00f6njes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, Pleier SV, Bai AHC, Karra D, Piro RM, Felsberg J, Addington A, Lemke D, Weibrecht I, Hovestadt V, Rolli CG, Campos B, Turcan S, Sturm D, Witt H, Chan TA, Herold-Mende C, Kemkemer R, K\u00f6nig R, Schmidt K, Hull WE, Pfister SM, Jugold M, Hutson SM, Plass C, Okun JG, Reifenberger G, Lichter P, Radlwimmer B (2013) BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat Med 19:901\u2013908. \nhttps:\/\/doi.org\/10.1038\/nm.3217","journal-title":"Nature Medicine"},{"key":"12_CR59","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1158\/1535-7163.MCT-09-0794","volume":"8","author":"W Tsai","year":"2009","unstructured":"Tsai W, Aiba I, Lee S, Feun L, Savaraj N, Kuo MT (2009) Resistance to arginine deiminase treatment in melanoma cells is associated with induced Argininosuccinate Synthetase expression involving c-Myc\/HIF-1\u03b1\/Sp4. Mol Cancer Ther 8:3223\u20133233. \nhttps:\/\/doi.org\/10.1158\/1535-7163.MCT-09-0794","journal-title":"Mol Cancer Ther"},{"key":"12_CR60","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00726-013-1586-x","volume":"45","author":"B Vynnytska-Myronovska","year":"2013","unstructured":"Vynnytska-Myronovska B, Kurlishchuk Y, Bobak Y, Dittfeld C, Kunz-Schughart LA, Stasyk O (2013) Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation. Amino Acids 45:1221\u20131230. \nhttps:\/\/doi.org\/10.1007\/s00726-013-1586-x","journal-title":"Amino Acids"},{"key":"12_CR61","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/CAD.0b013e32833e0334","volume":"22","author":"BO Vynnytska","year":"2011","unstructured":"Vynnytska BO, Mayevska OM, Kurlishchuk YV, Bobak YP, Stasyk OV (2011) Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells. Anti-Cancer Drugs 22:148\u2013157. \nhttps:\/\/doi.org\/10.1097\/CAD.0b013e32833e0334","journal-title":"Anti-Cancer Drugs"},{"key":"12_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050258","volume":"5","author":"CC Wong","year":"2007","unstructured":"Wong CC, Xu T, Rai R, Bailey AO, Yates JR 3rd, Wolf YI, Zebroski H, Kashina A (2007) Global analysis of posttranslational protein arginylation. PLoS Biol 5:e258. \nhttps:\/\/doi.org\/10.1371\/journal.pbio.0050258","journal-title":"PLoS Biol"},{"key":"12_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3360001","volume":"336","author":"G Wu","year":"1998","unstructured":"Wu G, Morris SMJR (1998) Arginine metabolism: nitric oxide and beyond. Biochem J 336:1\u201317. \nhttps:\/\/doi.org\/10.1042\/bj3360001","journal-title":"Biochem J"},{"key":"12_CR65","first-page":"211","volume":"2","author":"J Yi","year":"2009","unstructured":"Yi J, Horky LL, Friedlich AL, Shi Y, Rogers JT, Huang X (2009) L-arginine and Alzheimer\u2019s disease. Int J Clin Exp Pathol 2:211\u2013238","journal-title":"Int J Clin Exp Pathol"},{"key":"12_CR66","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2174\/1872208313666181220121400","volume":"3","author":"M Zarei","year":"2019","unstructured":"Zarei M, Rahbar MR, Morowvat MH, Nezafat N, Negahdaripour M, Berenjian A, Ghasemi Y (2019) Arginine deiminase: current understanding and applications. Recent Pat Biotechnol 3:124\u2013136. \nhttps:\/\/doi.org\/10.2174\/1872208313666181220121400","journal-title":"Recent Pat Biotechnol"},{"key":"12_CR67","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1083\/jcb.201112129","volume":"197","author":"F Zhang","year":"2012","unstructured":"Zhang F, Saha S, Kashina A (2012) Arginylation-dependent regulation of a proteolytic product of Talin is essential for cell-cell adhesion. J Cell Biol 197:819\u2013836. \nhttps:\/\/doi.org\/10.1083\/jcb.201112129","journal-title":"J Cell Biol"},{"key":"12_CR68","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1126\/science.1191701","volume":"329","author":"F Zhang","year":"2010","unstructured":"Zhang F, Saha S, Shabalina SA, Kashina A (2010) Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation. Science 329:1534\u20131537. \nhttps:\/\/doi.org\/10.1126\/science.1191701","journal-title":"Science"}],"container-title":["Advances in Experimental Medicine and Biology","Glioma Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-30651-9_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T17:03:27Z","timestamp":1581095007000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-30651-9_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030306502","9783030306519"],"references-count":63,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-30651-9_12","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"8 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}