{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T02:23:23Z","timestamp":1743128603213,"version":"3.40.3"},"publisher-location":"Cham","reference-count":33,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030366827"},{"type":"electronic","value":"9783030366834"}],"license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-36683-4_61","type":"book-chapter","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T17:08:15Z","timestamp":1574788095000},"page":"762-773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational Modelling of TNF\u03b1 Pathway in Parkinson\u2019s Disease \u2013 A Systemic Perspective"],"prefix":"10.1007","author":[{"given":"Hemalatha","family":"Sasidharakurup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanishka","family":"Bhaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Diwakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"61_CR1","first-page":"1","volume":"2017","author":"Z Ji","year":"2017","unstructured":"Ji, Z., Yan, K., Li, W., Hu, H., Zhu, X.: Mathematical and computational modeling in complex biological systems. Biomed. Res. Int. 2017, 1\u201316 (2017)","journal-title":"Biomed. Res. Int."},{"key":"61_CR2","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","volume":"17","author":"E Ray Dorsey","year":"2018","unstructured":"Ray Dorsey, E., et al.: Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 17, 939\u2013953 (2018)","journal-title":"Lancet Neurol."},{"key":"61_CR3","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/mds.21035","volume":"21","author":"M Ragothaman","year":"2006","unstructured":"Ragothaman, M., Govindappa, S.T., Rattihalli, R., Subbakrishna, D.K., Muthane, U.B.: Direct costs of managing Parkinson\u2019s disease in india: concerns in a developing country. Mov. Disord. 21, 1755\u20131758 (2006)","journal-title":"Mov. Disord."},{"key":"61_CR4","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1523\/JNEUROSCI.22-08-03090.2002","volume":"22","author":"RG Perez","year":"2002","unstructured":"Perez, R.G., et al.: A role for \u03b1-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22, 3090\u20133099 (2002)","journal-title":"J. Neurosci."},{"key":"61_CR5","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1089\/omi.2017.0056","volume":"21","author":"H Sasidharakurup","year":"2017","unstructured":"Sasidharakurup, H., Melethadathil, N., Nair, B., Diwakar, S.: A systems model of Parkinson\u2019s disease using biochemical systems theory. Omics J. Integr. Biol. 21, 454\u2013464 (2017)","journal-title":"Omics J. Integr. Biol."},{"key":"61_CR6","first-page":"113","volume":"8","author":"S Stayte","year":"2014","unstructured":"Stayte, S., Vissel, B.: Advances in non-dopaminergic treatments for Parkinson\u2019s disease. Front. Neurosci. 8, 113 (2014)","journal-title":"Front. Neurosci."},{"key":"61_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neulet.2017.08.049","volume":"658","author":"JD Lindenau","year":"2017","unstructured":"Lindenau, J.D., Altmann, V., Schumacher-Schuh, A.F., Rieder, C.R., Hutz, M.H.: Tumor necrosis factor alpha polymorphisms are associated with Parkinson\u2019s disease age at onset. Neurosci. Lett. 658, 133\u2013136 (2017)","journal-title":"Neurosci. Lett."},{"key":"61_CR8","doi-asserted-by":"publisher","unstructured":"Nagatsu, T., Sawada, M.: Biochemistry of postmortem brains in Parkinson\u2019s disease: historical overview and future prospects. J. Neural Transm. Suppl. 113\u2013120 (2007). \nhttps:\/\/doi.org\/10.1007\/978-3-211-73574-9-14","DOI":"10.1007\/978-3-211-73574-9-14"},{"key":"61_CR9","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1001\/jamaneurol.2018.0605","volume":"75","author":"I Peter","year":"2018","unstructured":"Peter, I., et al.: Anti-tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease. JAMA Neurol. 75, 939 (2018)","journal-title":"JAMA Neurol."},{"key":"61_CR10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/mt.2010.217","volume":"19","author":"AS Harms","year":"2011","unstructured":"Harms, A.S., et al.: Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson\u2019s disease. Mol. Ther. 19, 46\u201352 (2011)","journal-title":"Mol. Ther."},{"key":"61_CR11","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1039\/C5IB00031A","volume":"7","author":"LB Wood","year":"2015","unstructured":"Wood, L.B., Winslow, A.R., Strasser, S.D., Wood, L., Israel, B.: Systems biology of neurodegenerative diseases graphical abstract HHS public access. Integr. Biol. (Camb.) 7, 758\u2013775 (2015)","journal-title":"Integr. Biol. (Camb.)"},{"key":"61_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.cytogfr.2007.04.002","volume":"18","author":"I Clark","year":"2007","unstructured":"Clark, I.: How TNF was recognized as a key mechanism of disease. Cytokine Growth Factor Rev. 18, 335\u2013343 (2007)","journal-title":"Cytokine Growth Factor Rev."},{"key":"61_CR13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1353-8020(99)00037-1","volume":"5","author":"A Parent","year":"1999","unstructured":"Parent, A., Parent, M., Charara, A.: Glutamatergic inputs to midbrain dopaminergic neurons in primates. Parkinsonism Relat. Disord. 5, 193\u2013201 (1999)","journal-title":"Parkinsonism Relat. Disord."},{"key":"61_CR14","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.clineuro.2018.01.022","volume":"166","author":"E Kouchaki","year":"2018","unstructured":"Kouchaki, E., et al.: Increased serum levels of TNF-\u03b1 and decreased serum levels of IL-27 in patients with Parkinson disease and their correlation with disease severity. Clin. Neurol. Neurosurg. 166, 76\u201379 (2018)","journal-title":"Clin. Neurol. Neurosurg."},{"key":"61_CR15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/j.1471-4159.2009.06178.x","volume":"110","author":"Y Izumi","year":"2009","unstructured":"Izumi, Y., et al.: Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. J. Neurochem. 110, 745\u2013755 (2009)","journal-title":"J. Neurochem."},{"key":"61_CR16","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/glia.10161","volume":"40","author":"U-K Hanisch","year":"2002","unstructured":"Hanisch, U.-K.: Microglia as a source and target of cytokines. Glia 40, 140\u2013155 (2002)","journal-title":"Glia"},{"key":"61_CR17","doi-asserted-by":"publisher","first-page":"21362","DOI":"10.1074\/jbc.M600504200","volume":"281","author":"H Takeuchi","year":"2006","unstructured":"Takeuchi, H., et al.: Tumor necrosis factor-\u03b1 induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 281, 21362\u201321368 (2006)","journal-title":"J. Biol. Chem."},{"key":"61_CR18","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/89490","volume":"4","author":"P Bezzi","year":"2001","unstructured":"Bezzi, P., et al.: CXCR18-activated astrocyte glutamate release via TNF\u03b1: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 4, 702\u2013710 (2001)","journal-title":"Nat. Neurosci."},{"key":"61_CR19","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.2353\/ajpath.2007.061232","volume":"170","author":"BM Dufty","year":"2007","unstructured":"Dufty, B.M., et al.: Calpain-cleavage of \u03b1-synuclein: connecting proteolytic processing to disease-linked aggregation. Am. J. Pathol. 170, 1725\u20131738 (2007)","journal-title":"Am. J. Pathol."},{"key":"61_CR20","doi-asserted-by":"publisher","first-page":"13650","DOI":"10.1073\/pnas.2232515100","volume":"100","author":"PD Smith","year":"2003","unstructured":"Smith, P.D., et al.: Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson\u2019s disease. Proc. Natl. Acad. Sci. 100, 13650\u201313655 (2003)","journal-title":"Proc. Natl. Acad. Sci."},{"key":"61_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/glia.10150","volume":"40","author":"K Inoue","year":"2002","unstructured":"Inoue, K.: Microglial activation by purines and pyrimidines. Glia 40, 156\u2013163 (2002)","journal-title":"Glia"},{"key":"61_CR22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fncel.2016.00134","volume":"10","author":"S Negro","year":"2016","unstructured":"Negro, S., et al.: ATP released by injured neurons activates Schwann cells. Front. Cell. Neurosci. 10, 134 (2016)","journal-title":"Front. Cell. Neurosci."},{"key":"61_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuint.2013.04.007","volume":"63","author":"JV Welser-Alves","year":"2013","unstructured":"Welser-Alves, J.V., Milner, R.: Microglia are the major source of TNF-\u03b1 and TGF-\u03b21 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem. Int. 63, 47\u201353 (2013)","journal-title":"Neurochem. Int."},{"key":"61_CR24","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/(SICI)1098-1136(199703)19:3<190::AID-GLIA2>3.0.CO;2-3","volume":"198","author":"VAM Vincent","year":"1997","unstructured":"Vincent, V.A.M., Tilders, F.J.H., Dam, A.V.A.N.: Inhibition of endotoxin-induced nitric oxide synthase production in microglial cells by the presence of astroglial cells: a role for transforming growth factor \u03b2. Glia 198, 190\u2013198 (1997)","journal-title":"Glia"},{"key":"61_CR25","doi-asserted-by":"publisher","unstructured":"Cabezas, R., et al.: Astrocytes role in Parkinson: a double-edged sword (2013). \nhttps:\/\/doi.org\/10.5772\/54305","DOI":"10.5772\/54305"},{"key":"61_CR26","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1046\/j.1471-4159.2001.00425.x","volume":"78","author":"E Junn","year":"2001","unstructured":"Junn, E., Mouradian, M.M.: Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. J. Neurochem. 78, 374\u2013383 (2001)","journal-title":"J. Neurochem."},{"key":"61_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/PL00007762","volume":"247","author":"EC Hirsch","year":"2000","unstructured":"Hirsch, E.C.: Glial cells and Parkinson\u2019 s disease. J. Neurol. 247, 58\u201362 (2000)","journal-title":"J. Neurol."},{"key":"61_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12026-008-8018-0","volume":"41","author":"L Qian","year":"2008","unstructured":"Qian, L., Flood, P.M.: Microglial cells and Parkinson\u2019s disease. Immunol. Res. 41, 155\u2013164 (2008)","journal-title":"Immunol. Res."},{"key":"61_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1515\/tnsci-2018-0022","volume":"9","author":"J He","year":"2018","unstructured":"He, J., Zhong, W., Zhang, M., Zhang, R., Hu, W.: P38 mitogen-activated protein kinase and Parkinson\u2019s disease. Transl. Neurosci. 9, 147 (2018)","journal-title":"Transl. Neurosci."},{"key":"61_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/jobm.19790190219","volume":"19","author":"W Knorre","year":"2007","unstructured":"Knorre, W.: M. A. Savageau, Biochemical Systems Analysis. A Study of Function and Design in Molecular Biology. 396 S., 115 Abb., 14 Tab. Reading, Mass. 1976. Addison-Wesley Pbl. Co.\/Advanced Book Program. \u00a3 26,50. Z. Allg. Mikrobiol. 19, 149\u2013150 (2007)","journal-title":"Z. Allg. Mikrobiol."},{"key":"61_CR31","doi-asserted-by":"crossref","unstructured":"Olmos, G., Llad\u00f3, J.: Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediat. Inflamm. 2014 (2014)","DOI":"10.1155\/2014\/861231"},{"key":"61_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fncel.2013.00053","volume":"7","author":"MC Leal","year":"2013","unstructured":"Leal, M.C., Casabona, J.C., Puntel, M., Pitossi, F.: Interleukin-1\u03b2 and TNF-\u03b1: reliable targets for protective therapies in Parkinson\u2019s disease? Front. Cell. Neurosci. 7, 53 (2013)","journal-title":"Front. Cell. Neurosci."},{"key":"61_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/610813","volume":"2015","author":"R Fischer","year":"2015","unstructured":"Fischer, R., Maier, O.: Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxidative Med. Cell. Longev. 2015, 1\u201318 (2015)","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Studies in Computational Intelligence","Complex Networks and Their Applications VIII"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-36683-4_61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T20:03:27Z","timestamp":1574798607000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-36683-4_61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"ISBN":["9783030366827","9783030366834"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-36683-4_61","relation":{},"ISSN":["1860-949X","1860-9503"],"issn-type":[{"type":"print","value":"1860-949X"},{"type":"electronic","value":"1860-9503"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"25 November 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"COMPLEX NETWORKS","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Complex Networks and Their Applications","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Lisbon","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Portugal","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2019","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 December 2019","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"12 December 2019","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"8","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"iwcna2019","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/www.complexnetworks.org\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}