{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:37:44Z","timestamp":1790429864470,"version":"4.1.0"},"publisher-location":"Cham","reference-count":159,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030402037","type":"print"},{"value":"9783030402044","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-40204-4_8","type":"book-chapter","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T13:04:00Z","timestamp":1586955840000},"page":"113-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications"],"prefix":"10.1007","author":[{"given":"Cynthia","family":"Lebeaupin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"8_CR1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","volume":"7","author":"JA Aguirre-Ghiso","year":"2007","unstructured":"Aguirre-Ghiso JA (2007) Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7:834\u2013846","journal-title":"Nat Rev Cancer"},{"key":"8_CR2","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.cell.2017.10.040","volume":"171","author":"N Amin-Wetzel","year":"2017","unstructured":"Amin-Wetzel N, Saunders RA, Kamphuis MJ, Rato C, Preissler S, Harding HP, Ron D (2017) A J-protein co-chaperone recruits BiP to monomerize IRE1 and repress the unfolded protein response. Cell 171:1625\u20131637.e1613","journal-title":"Cell"},{"key":"8_CR3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.febslet.2005.11.072","volume":"580","author":"M Arai","year":"2006","unstructured":"Arai M, Kondoh N, Imazeki N, Hada A, Hatsuse K, Kimura F, Matsubara O, Mori K, Wakatsuki T, Yamamoto M (2006) Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis. FEBS Lett 580:184\u2013190","journal-title":"FEBS Lett"},{"key":"8_CR4","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","volume":"73","author":"C Atkins","year":"2013","unstructured":"Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N et al (2013) Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 73:1993\u20132002","journal-title":"Cancer Res"},{"key":"8_CR5","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1074\/jbc.M311862200","volume":"279","author":"J Averous","year":"2004","unstructured":"Averous J, Bruhat A, Jousse C, Carraro V, Thiel G, Fafournoux P (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem 279:5288\u20135297","journal-title":"J Biol Chem"},{"key":"8_CR6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1021\/ml400228e","volume":"4","author":"JM Axten","year":"2013","unstructured":"Axten JM, Romeril SP, Shu A, Ralph J, Medina JR, Feng Y, Li WH, Grant SW, Heerding DA, Minthorn E et al (2013) Discovery of GSK2656157: an optimized PERK inhibitor selected for preclinical development. ACS Med Chem Lett 4:964\u2013968","journal-title":"ACS Med Chem Lett"},{"key":"8_CR7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2009.06.002","volume":"10","author":"SH Back","year":"2009","unstructured":"Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ (2009) Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab 10:13\u201326","journal-title":"Cell Metab"},{"key":"8_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2370359","volume":"2017","author":"M Badolato","year":"2017","unstructured":"Badolato M, Carullo G, Aiello F, Garofalo A (2017) Synthesis and experimental validation of new PDI inhibitors with antiproliferative activity. J Chem 2017:1\u20139","journal-title":"J Chem"},{"key":"8_CR9","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1074\/jbc.M109.056648","volume":"285","author":"B Bailly-Maitre","year":"2010","unstructured":"Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D et al (2010) Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem 285:6198\u20136207","journal-title":"J Biol Chem"},{"key":"8_CR10","volume":"1","author":"I Ben Mosbah","year":"2010","unstructured":"Ben Mosbah I, Alfany-Fernandez I, Martel C, Zaouali MA, Bintanel-Morcillo M, Rimola A, Rodes J, Brenner C, Rosello-Catafau J, Peralta C (2010) Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis 1:e52","journal-title":"Cell Death Dis"},{"key":"8_CR11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/intimm\/dxl049","volume":"18","author":"C Biswas","year":"2006","unstructured":"Biswas C, Sriram U, Ciric B, Ostrovsky O, Gallucci S, Argon Y (2006) The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells. Int Immunol 18:1147\u20131157","journal-title":"Int Immunol"},{"key":"8_CR12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41467-018-08129-2","volume":"10","author":"EA Blackwood","year":"2019","unstructured":"Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC (2019) Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun 10:187","journal-title":"Nat Commun"},{"key":"8_CR13","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1128\/MCB.24.17.7469-7482.2004","volume":"24","author":"JD Blais","year":"2004","unstructured":"Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC (2004) Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol 24:7469\u20137482","journal-title":"Mol Cell Biol"},{"key":"8_CR14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-immunol-032712-095910","volume":"31","author":"JS Blum","year":"2013","unstructured":"Blum JS, Wearsch PA, Cresswell P (2013) Pathways of antigen processing. Annu Rev Immunol 31:443\u2013473","journal-title":"Annu Rev Immunol"},{"key":"8_CR15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","volume":"21","author":"SS Cao","year":"2014","unstructured":"Cao SS, Kaufman RJ (2014) Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal 21:396\u2013413","journal-title":"Antioxid Redox Signal"},{"key":"8_CR16","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2013.01.023","volume":"144","author":"SS Cao","year":"2013","unstructured":"Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ (2013) The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology 144:989\u20131000.e6","journal-title":"Gastroenterology"},{"key":"8_CR17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ccr.2007.02.015","volume":"11","author":"DR Carrasco","year":"2007","unstructured":"Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS et al (2007) The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11:349\u2013360","journal-title":"Cancer Cell"},{"key":"8_CR18","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41556-019-0329-y","volume":"21","author":"A Carreras-Sureda","year":"2019","unstructured":"Carreras-Sureda A, Jana F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernandez E, Sassano ML et al (2019) Non-canonical function of IRE1alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol 21:755\u2013767","journal-title":"Nat Cell Biol"},{"key":"8_CR19","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.ccell.2016.04.013","volume":"29","author":"M Cerezo","year":"2016","unstructured":"Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H et al (2016) Compounds triggering ER stress exert anti-melanoma effects and overcome BRAF inhibitor resistance. Cancer Cell 29:805\u2013819","journal-title":"Cancer Cell"},{"key":"8_CR20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature13119","volume":"508","author":"X Chen","year":"2014","unstructured":"Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y et al (2014) XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway. Nature 508:103\u2013107","journal-title":"Nature"},{"key":"8_CR21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/brain\/awy322","volume":"142","author":"Y Chen","year":"2019","unstructured":"Chen Y, Podojil JR, Kunjamma RB, Jones J, Weiner M, Lin W, Miller SD, Popko B (2019) Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain 142:344\u2013361","journal-title":"Brain"},{"key":"8_CR22","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1053\/j.gastro.2018.07.028","volume":"155","author":"OI Coleman","year":"2018","unstructured":"Coleman OI, Lobner EM, Bierwirth S, Sorbie A, Waldschmitt N, Rath E, Berger E, Lagkouvardos I, Clavel T, McCoy KD et al (2018) Activated ATF6 induces intestinal dysbiosis and innate immune response to promote colorectal tumorigenesis. Gastroenterology 155:1539\u20131552.e12","journal-title":"Gastroenterology"},{"key":"8_CR23","doi-asserted-by":"crossref","first-page":"pii: e26109","DOI":"10.7554\/eLife.26109","volume":"6","author":"A Crespillo-Casado","year":"2017","unstructured":"Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D (2017) PPP1R15A-mediated dephosphorylation of eIF2alpha is unaffected by Sephin1 or Guanabenz. Elife 6:pii: e26109","journal-title":"Elife"},{"key":"8_CR24","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cell.2016.12.004","volume":"168","author":"JR Cubillos-Ruiz","year":"2017","unstructured":"Cubillos-Ruiz JR, Bettigole SE, Glimcher LH (2017) Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell 168:692\u2013706","journal-title":"Cell"},{"key":"8_CR25","doi-asserted-by":"crossref","first-page":"20108","DOI":"10.1074\/jbc.M314219200","volume":"279","author":"SB Cullinan","year":"2004","unstructured":"Cullinan SB, Diehl JA (2004) PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279:20108\u201320117","journal-title":"J Biol Chem"},{"key":"8_CR26","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/MCB.23.20.7198-7209.2003","volume":"23","author":"SB Cullinan","year":"2003","unstructured":"Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198\u20137209","journal-title":"Mol Cell Biol"},{"key":"8_CR27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.aaa4484","volume":"348","author":"I Das","year":"2015","unstructured":"Das I, Krzyzosiak A, Schneider K, Wrabetz L, D\u2019Antonio M, Barry N, Sigurdardottir A, Bertolotti A (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348:239","journal-title":"Science"},{"key":"8_CR28","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1242\/jcs.099291","volume":"125","author":"N Dejeans","year":"2012","unstructured":"Dejeans N, Pluquet O, Lhomond S, Grise F, Bouchecareilh M, Juin A, Meynard-Cadars M, Bidaud-Meynard A, Gentil C, Moreau V et al (2012) Autocrine control of glioma cells adhesion and migration through IRE1\u03b1-mediated cleavage of SPARC mRNA. J Cell Sci 125:4278","journal-title":"J Cell Sci"},{"key":"8_CR29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/78085","volume":"25","author":"M Delepine","year":"2000","unstructured":"Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C (2000) EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet 25:406\u2013409","journal-title":"Nat Genet"},{"key":"8_CR30","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/ncb1471","volume":"8","author":"C Denoyelle","year":"2006","unstructured":"Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA et al (2006) Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol 8:1053\u20131063","journal-title":"Nat Cell Biol"},{"key":"8_CR31","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1158\/0008-5472.CAN-10-3151","volume":"71","author":"D Dong","year":"2011","unstructured":"Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, Jhaveri N, Zhu G, Ye R, Liu Z et al (2011) A critical role for GRP78\/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res 71:2848\u20132857","journal-title":"Cancer Res"},{"key":"8_CR32","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1128\/MCB.8.10.4063","volume":"8","author":"AJ Dorner","year":"1988","unstructured":"Dorner AJ, Krane MG, Kaufman RJ (1988) Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells. Mol Cell Biol 8:4063\u20134070","journal-title":"Mol Cell Biol"},{"key":"8_CR33","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1073\/pnas.87.19.7429","volume":"87","author":"AJ Dorner","year":"1990","unstructured":"Dorner AJ, Wasley LC, Kaufman RJ (1990) Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels. Proc Natl Acad Sci U S A 87:7429\u20137432","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR34","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/j.1460-2075.1992.tb05201.x","volume":"11","author":"AJ Dorner","year":"1992","unstructured":"Dorner AJ, Wasley LC, Kaufman RJ (1992) Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells. EMBO J 11:1563\u20131571","journal-title":"EMBO J"},{"key":"8_CR35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.molcel.2014.01.004","volume":"53","author":"D Eletto","year":"2014","unstructured":"Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y (2014) Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association. Mol Cell 53:562\u2013576","journal-title":"Mol Cell"},{"key":"8_CR36","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1158\/2159-8290.CD-13-0945","volume":"4","author":"YX Feng","year":"2014","unstructured":"Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q et al (2014) Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress. Cancer Discov 4:702\u2013715","journal-title":"Cancer Discov"},{"key":"8_CR37","unstructured":"Flaherty D, Golden J, Liu C, Hedrick M, Gosalia P, Liou Y, Milewski M, Sugarman E, Suyama E, Nguyen K et al (2013) Selective small molecule activator of the apoptotic arm of the UPR. In (Bethesda (MD): National Center for Biotechnology Information: Probe Reports from the NIH Molecular Libraries Program)"},{"key":"8_CR38","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/ml5003234","volume":"5","author":"DP Flaherty","year":"2014","unstructured":"Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S et al (2014) Discovery of sulfonamidebenzamides as selective apoptotic CHOP pathway activators of the unfolded protein response. ACS Med Chem Lett 5:1278\u20131283","journal-title":"ACS Med Chem Lett"},{"key":"8_CR39","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1158\/0008-5472.CAN-06-4594","volume":"67","author":"Y Fu","year":"2007","unstructured":"Fu Y, Li J, Lee AS (2007) GRP78\/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res 67:3734\u20133740","journal-title":"Cancer Res"},{"key":"8_CR40","doi-asserted-by":"crossref","first-page":"pii: e11878","DOI":"10.7554\/eLife.11878","volume":"5","author":"CM Gallagher","year":"2016","unstructured":"Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR et al (2016) Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6alpha branch. Elife 5:pii: e11878","journal-title":"Elife"},{"key":"8_CR41","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cell.2014.07.002","volume":"158","author":"R Ghosh","year":"2014","unstructured":"Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H et al (2014) Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 158:534\u2013548","journal-title":"Cell"},{"key":"8_CR42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1158\/0008-5472.CAN-03-2144","volume":"64","author":"MA Ginos","year":"2004","unstructured":"Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, Ondrey FG, Adams GL, Gaffney PM (2004) Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res 64:55\u201363","journal-title":"Cancer Res"},{"key":"8_CR43","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1158\/0008-5472.CAN-05-4589","volume":"66","author":"D Goplen","year":"2006","unstructured":"Goplen D, Wang J, Enger PO, Tysnes BB, Terzis AJ, Laerum OD, Bjerkvig R (2006) Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res 66:9895\u20139902","journal-title":"Cancer Res"},{"key":"8_CR44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-10-10","volume":"10","author":"DP Granados","year":"2009","unstructured":"Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C (2009) ER stress affects processing of MHC class I-associated peptides. BMC Immunol 10:10","journal-title":"BMC Immunol"},{"key":"8_CR45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature05610","volume":"446","author":"C Greenman","year":"2007","unstructured":"Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C et al (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153\u2013158","journal-title":"Nature"},{"key":"8_CR46","doi-asserted-by":"crossref","first-page":"ra54","DOI":"10.1126\/scisignal.2004983","volume":"7","author":"J Groenendyk","year":"2014","unstructured":"Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y et al (2014) Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal 7:ra54","journal-title":"Sci Signal"},{"key":"8_CR47","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1038\/onc.2016.121","volume":"35","author":"A Gupta","year":"2016","unstructured":"Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S (2016) NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK\u2013eIF2\u03b1\u2013ATF4 signalling in breast cancer. Oncogene 35:5860","journal-title":"Oncogene"},{"key":"8_CR48","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","volume":"138","author":"D Han","year":"2009","unstructured":"Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR (2009) IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138:562\u2013575","journal-title":"Cell"},{"key":"8_CR49","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","volume":"15","author":"J Han","year":"2013","unstructured":"Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M et al (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15:481\u2013490","journal-title":"Nat Cell Biol"},{"key":"8_CR50","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.2337\/db14-1357","volume":"64","author":"J Han","year":"2015","unstructured":"Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH et al (2015) Antioxidants complement the requirement for protein chaperone function to maintain \u03b2-cell function and glucose homeostasis. Diabetes 64:2892\u20132904","journal-title":"Diabetes"},{"key":"8_CR51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","volume":"397","author":"HP Harding","year":"1999","unstructured":"Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271\u2013274","journal-title":"Nature"},{"key":"8_CR52","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","volume":"11","author":"HP Harding","year":"2003","unstructured":"Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R et al (2003) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11:619\u2013633","journal-title":"Mol Cell"},{"key":"8_CR53","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","volume":"122","author":"LS Hart","year":"2012","unstructured":"Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M et al (2012) ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest 122:4621\u20134634","journal-title":"J Clin Invest"},{"key":"8_CR54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002277","volume":"13","author":"JR Hassler","year":"2015","unstructured":"Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP et al (2015) The IRE1alpha\/XBP1s pathway is essential for the glucose response and protection of beta cells. PLoS Biol 13:e1002277","journal-title":"PLoS Biol"},{"key":"8_CR55","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","volume":"10","author":"K Haze","year":"1999","unstructured":"Haze K, Yoshida H, Yanagi H, Yura T, Mori K (1999) Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 10:3787\u20133799","journal-title":"Mol Biol Cell"},{"key":"8_CR56","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.molcel.2009.08.021","volume":"35","author":"C Hetz","year":"2009","unstructured":"Hetz C, Glimcher LH (2009) Fine-tuning of the unfolded protein response: assembling the IRE1\u03b1 interactome. Mol Cell 35:551\u2013561","journal-title":"Mol Cell"},{"key":"8_CR57","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1123480","volume":"312","author":"C Hetz","year":"2006","unstructured":"Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH et al (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312:572\u2013576","journal-title":"Science"},{"key":"8_CR58","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","volume":"91","author":"C Hetz","year":"2011","unstructured":"Hetz C, Martinon F, Rodriguez D, Glimcher LH (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha. Physiol Rev 91:1219\u20131243","journal-title":"Physiol Rev"},{"key":"8_CR59","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrd3976","volume":"12","author":"C Hetz","year":"2013","unstructured":"Hetz C, Chevet E, Harding HP (2013) Targeting the unfolded protein response in disease. Nat Rev Drug Discov 12:703\u2013719","journal-title":"Nat Rev Drug Discov"},{"key":"8_CR60","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ncb3184","volume":"17","author":"C Hetz","year":"2015","unstructured":"Hetz C, Chevet E, Oakes SA (2015) Proteostasis control by the unfolded protein response. Nat Cell Biol 17:829\u2013838","journal-title":"Nat Cell Biol"},{"key":"8_CR61","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1128\/MCB.01484-13","volume":"34","author":"A Higa","year":"2014","unstructured":"Higa A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R, Chevet E (2014) Endoplasmic reticulum stress-activated transcription factor ATF6alpha requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol Cell Biol 34:1839\u20131849","journal-title":"Mol Cell Biol"},{"key":"8_CR62","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","volume":"313","author":"J Hollien","year":"2006","unstructured":"Hollien J, Weissman JS (2006) Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313:104","journal-title":"Science"},{"key":"8_CR63","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","volume":"186","author":"J Hollien","year":"2009","unstructured":"Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol 186:323","journal-title":"J Cell Biol"},{"key":"8_CR64","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/bjh.12310","volume":"161","author":"SY Hong","year":"2013","unstructured":"Hong SY, Hagen T (2013) Multiple myeloma Leu167Ile (c.499C>A) mutation prevents XBP1 mRNA splicing. Br J Haematol 161:898\u2013901","journal-title":"Br J Haematol"},{"key":"8_CR65","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.molcel.2013.01.009","volume":"49","author":"AL Huber","year":"2013","unstructured":"Huber AL, Lebeau J, Guillaumot P, Petrilli V, Malek M, Chilloux J, Fauvet F, Payen L, Kfoury A, Renno T et al (2013) p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol Cell 49:1049\u20131059","journal-title":"Mol Cell"},{"key":"8_CR66","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","volume":"285","author":"A Jain","year":"2010","unstructured":"Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A, McMahon M, Hayes JD, Johansen T (2010) p62\/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285:22576\u201322591","journal-title":"J Biol Chem"},{"key":"8_CR67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2018.10.007","volume":"440\u2013441","author":"N Ji","year":"2019","unstructured":"Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D, Chen ZS (2019) Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Lett 440\u2013441:82\u201393","journal-title":"Cancer Lett"},{"key":"8_CR68","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature09208","volume":"466","author":"Z Kan","year":"2010","unstructured":"Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J et al (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 466:869\u2013873","journal-title":"Nature"},{"key":"8_CR69","doi-asserted-by":"crossref","first-page":"pii: e30700","DOI":"10.7554\/eLife.30700","volume":"6","author":"GE Karagoz","year":"2017","unstructured":"Karagoz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P (2017) An unfolded protein-induced conformational switch activates mammalian IRE1. Elife 6:pii: e30700","journal-title":"Elife"},{"key":"8_CR70","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tibs.2004.01.004","volume":"29","author":"RJ Kaufman","year":"2004","unstructured":"Kaufman RJ (2004) Regulation of mRNA translation by protein folding in the endoplasmic reticulum. Trends Biochem Sci 29:152\u2013158","journal-title":"Trends Biochem Sci"},{"key":"8_CR71","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.bbamcr.2014.03.022","volume":"1843","author":"RJ Kaufman","year":"2014","unstructured":"Kaufman RJ, Malhotra JD (2014) Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim Biophys Acta 1843:2233\u20132239","journal-title":"Biochim Biophys Acta"},{"key":"8_CR72","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.4049\/jimmunol.1401399","volume":"194","author":"S Kim","year":"2015","unstructured":"Kim S, Joe Y, Kim HJ, Kim YS, Jeong SO, Pae HO, Ryter SW, Surh YJ, Chung HT (2015) Endoplasmic reticulum stress-induced IRE1alpha activation mediates cross-talk of GSK-3beta and XBP-1 to regulate inflammatory cytokine production. J Immunol 194:4498\u20134506","journal-title":"J Immunol"},{"key":"8_CR73","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nature07661","volume":"457","author":"AV Korennykh","year":"2009","unstructured":"Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457:687\u2013693","journal-title":"Nature"},{"key":"8_CR74","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.cell.2018.06.030","volume":"174","author":"A Krzyzosiak","year":"2018","unstructured":"Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, Bertolotti A (2018) Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B. Cell 174:1216\u20131228.e19","journal-title":"Cell"},{"key":"8_CR75","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1158\/0008-5472.CAN-16-3196","volume":"77","author":"CY Kuo","year":"2017","unstructured":"Kuo CY, Lin CH, Hsu T (2017) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1alpha signaling. Cancer Res 77:3406\u20133416","journal-title":"Cancer Res"},{"key":"8_CR76","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1113\/JP273059","volume":"595","author":"JQ Kwong","year":"2017","unstructured":"Kwong JQ (2017) The mitochondrial calcium uniporter in the heart: energetics and beyond. J Physiol 595:3743\u20133751","journal-title":"J Physiol"},{"key":"8_CR77","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.celrep.2015.06.002","volume":"12","author":"JQ Kwong","year":"2015","unstructured":"Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD (2015) The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart. Cell Rep 12:15\u201322","journal-title":"Cell Rep"},{"key":"8_CR78","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ceca.2016.04.005","volume":"60","author":"RM La Rovere","year":"2016","unstructured":"La Rovere RM, Roest G, Bultynck G, Parys JB (2016) Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy. Cell Calcium 60:74\u201387","journal-title":"Cell Calcium"},{"key":"8_CR79","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.248","volume":"6","author":"C Lebeaupin","year":"2015","unstructured":"Lebeaupin C, Proics E, de Bieville CH, Rousseau D, Bonnafous S, Patouraux S, Adam G, Lavallard VJ, Rovere C, Le Thuc O et al (2015) ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis 6:e1879","journal-title":"Cell Death Dis"},{"key":"8_CR80","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","volume":"69","author":"C Lebeaupin","year":"2018","unstructured":"Lebeaupin C, Vallee D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B (2018a) Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J Hepatol 69:927\u2013947","journal-title":"J Hepatol"},{"key":"8_CR81","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.29847","volume":"68","author":"C Lebeaupin","year":"2018","unstructured":"Lebeaupin C, Vallee D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Luciano F, Luci C, Anty R, Iannelli A et al (2018b) Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. Hepatology 68:515\u2013532","journal-title":"Hepatology"},{"key":"8_CR82","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cell.2007.10.057","volume":"132","author":"KP Lee","year":"2008","unstructured":"Lee KP, Dey M, Neculai D, Cao C, Dever TE, Sicheri F (2008) Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell 132:89\u2013100","journal-title":"Cell"},{"key":"8_CR83","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","volume":"16","author":"AG Lerner","year":"2012","unstructured":"Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M et al (2012) IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab 16:250\u2013264","journal-title":"Cell Metab"},{"key":"8_CR84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccr.2013.08.009","volume":"24","author":"C Leung-Hagesteijn","year":"2013","unstructured":"Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, Reece DE, Chung KC, Tiedemann RE (2013) Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell 24:289\u2013304","journal-title":"Cancer Cell"},{"issue":"3","key":"8_CR85","doi-asserted-by":"crossref","first-page":"pii: e7929","DOI":"10.15252\/emmm.201707929","volume":"10","author":"S Lhomond","year":"2018","unstructured":"Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F et al (2018) Dual IRE1 RNase functions dictate glioblastoma development. EMBO Mol Med 10(3):pii: e7929","journal-title":"EMBO Mol Med"},{"key":"8_CR86","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.200904060","volume":"186","author":"G Li","year":"2009","unstructured":"Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I (2009) Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 186:783\u2013792","journal-title":"J Cell Biol"},{"key":"8_CR87","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1158\/1078-0432.CCR-05-2734","volume":"13","author":"YH Lin","year":"2007","unstructured":"Lin YH, Friederichs J, Black MA, Mages J, Rosenberg R, Guilford PJ, Phillips V, Thompson-Fawcett M, Kasabov N, Toro T et al (2007) Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clin Cancer Res 13:498\u2013507","journal-title":"Clin Cancer Res"},{"key":"8_CR88","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.molcel.2009.02.017","volume":"33","author":"F Lisbona","year":"2009","unstructured":"Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P et al (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell 33:679\u2013691","journal-title":"Mol Cell"},{"key":"8_CR89","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.celrep.2016.07.011","volume":"16","author":"JC Liu","year":"2016","unstructured":"Liu JC, Liu J, Holmstrom KM, Menazza S, Parks RJ, Fergusson MM, Yu ZX, Springer DA, Halsey C, Liu C et al (2016) MICU1 serves as a molecular gatekeeper to prevent in vivo mitochondrial calcium overload. Cell Rep 16:1561\u20131573","journal-title":"Cell Rep"},{"issue":"2","key":"8_CR90","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/hep.29514","volume":"67","author":"R Loomba","year":"2017","unstructured":"Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP et al (2017) The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial. Hepatology 67(2):549\u2013559","journal-title":"Hepatology"},{"key":"8_CR91","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2337\/db07-1762","volume":"58","author":"DS Luciani","year":"2008","unstructured":"Luciani DS, Gwiazda KS, Yang TLB, Kalynyak TB, Bychkivska Y, Frey MHZ, Jeffrey KD, Sampaio AV, Underhill TM, Johnson JD (2008) Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 58:422\u2013432","journal-title":"Diabetes"},{"key":"8_CR92","doi-asserted-by":"crossref","first-page":"34864","DOI":"10.1074\/jbc.M301107200","volume":"278","author":"Y Ma","year":"2003","unstructured":"Ma Y, Hendershot LM (2003) Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J Biol Chem 278:34864\u201334873","journal-title":"J Biol Chem"},{"key":"8_CR93","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1172\/JCI70454","volume":"124","author":"X-H Ma","year":"2014","unstructured":"Ma X-H, Piao S-F, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G et al (2014) Targeting ER stress\u2013induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest 124:1406\u20131417","journal-title":"J Clin Invest"},{"key":"8_CR94","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","volume":"9","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9:2277\u20132293","journal-title":"Antioxid Redox Signal"},{"key":"8_CR95","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1073\/pnas.0809677105","volume":"105","author":"JD Malhotra","year":"2008","unstructured":"Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ (2008) Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A 105:18525\u201318530","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR96","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ncb2622","volume":"14","author":"K Mallilankaraman","year":"2012","unstructured":"Mallilankaraman K, Cardenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenar T, Csordas G, Madireddi P, Yang J, Muller M et al (2012) MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol 14:1336\u20131343","journal-title":"Nat Cell Biol"},{"key":"8_CR97","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1152\/physrev.00015.2006","volume":"86","author":"SJ Marciniak","year":"2006","unstructured":"Marciniak SJ, Ron D (2006) Endoplasmic reticulum stress signaling in disease. Physiol Rev 86:1133\u20131149","journal-title":"Physiol Rev"},{"key":"8_CR98","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1101\/gad.1250704","volume":"18","author":"SJ Marciniak","year":"2004","unstructured":"Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18:3066\u20133077","journal-title":"Genes Dev"},{"key":"8_CR99","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2014.02.008","volume":"39","author":"M Maurel","year":"2014","unstructured":"Maurel M, Chevet E, Tavernier J, Gerlo S (2014) Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem Sci 39:245\u2013254","journal-title":"Trends Biochem Sci"},{"key":"8_CR100","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.nbd.2018.01.004","volume":"112","author":"G Mercado","year":"2018","unstructured":"Mercado G, Castillo V, Soto P, Lopez N, Axten JM, Sardi SP, Hoozemans JJM, Hetz C (2018) Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson\u2019s disease. Neurobiol Dis 112:136\u2013148","journal-title":"Neurobiol Dis"},{"key":"8_CR101","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1182\/blood-2003-10-3591","volume":"103","author":"HZ Miao","year":"2004","unstructured":"Miao HZ, Sirachainan N, Palmer L, Kucab P, Cunningham MA, Kaufman RJ, Pipe SW (2004) Bioengineering of coagulation factor VIII for improved secretion. Blood 103:3412\u20133419","journal-title":"Blood"},{"key":"8_CR102","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1158\/0008-5472.CAN-08-2839","volume":"69","author":"M Milani","year":"2009","unstructured":"Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL (2009) The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res 69:4415\u20134423","journal-title":"Cancer Res"},{"key":"8_CR103","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1182\/blood-2011-07-366633","volume":"119","author":"N Mimura","year":"2012","unstructured":"Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H et al (2012) Blockade of XBP1 splicing by inhibition of IRE1alpha is a promising therapeutic option in multiple myeloma. Blood 119:5772\u20135781","journal-title":"Blood"},{"key":"8_CR104","doi-asserted-by":"crossref","first-page":"pii: E1706","DOI":"10.3390\/ijms20071706","volume":"20","author":"J Mimura","year":"2019","unstructured":"Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S et al (2019) Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes. Int J Mol Sci 20:pii: E1706","journal-title":"Int J Mol Sci"},{"key":"8_CR105","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cmet.2017.03.018","volume":"25","author":"S Morita","year":"2017","unstructured":"Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K et al (2017) Targeting ABL-IRE1alpha signaling spares ER-stressed pancreatic beta cells to reverse autoimmune diabetes. Cell Metab 25:883\u2013897.e8","journal-title":"Cell Metab"},{"key":"8_CR106","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1158\/1078-0432.CCR-13-0526","volume":"19","author":"H Mujcic","year":"2013","unstructured":"Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP et al (2013) Hypoxic activation of the PERK\/eIF2alpha arm of the unfolded protein response promotes metastasis through induction of LAMP3. Clin Cancer Res 19:6126\u20136137","journal-title":"Clin Cancer Res"},{"key":"8_CR107","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1091\/mbc.e03-09-0693","volume":"15","author":"S Nadanaka","year":"2004","unstructured":"Nadanaka S, Yoshida H, Kano F, Murata M, Mori K (2004) Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum. Mol Biol Cell 15:2537\u20132548","journal-title":"Mol Biol Cell"},{"key":"8_CR108","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","volume":"26","author":"H Nakagawa","year":"2014","unstructured":"Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J et al (2014) ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26:331\u2013343","journal-title":"Cancer Cell"},{"key":"8_CR109","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1084\/jem.20122341","volume":"210","author":"L Niederreiter","year":"2013","unstructured":"Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC et al (2013) ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med 210:2041\u20132056","journal-title":"J Exp Med"},{"key":"8_CR110","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.153.5.1011","volume":"153","author":"I Novoa","year":"2001","unstructured":"Novoa I, Zeng H, Harding HP, Ron D (2001) Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2\u03b1. J Cell Biol 153:1011","journal-title":"J Cell Biol"},{"key":"8_CR111","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","volume":"26","author":"M Ogata","year":"2006","unstructured":"Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K et al (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220","journal-title":"Mol Cell Biol"},{"key":"8_CR112","doi-asserted-by":"crossref","first-page":"31024","DOI":"10.1074\/jbc.M300923200","volume":"278","author":"T Okada","year":"2003","unstructured":"Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K (2003) A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 278:31024\u201331032","journal-title":"J Biol Chem"},{"key":"8_CR113","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s00535-012-0552-9","volume":"47","author":"K Okada","year":"2012","unstructured":"Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K et al (2012) Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. J Gastroenterol 47:924\u2013935","journal-title":"J Gastroenterol"},{"key":"8_CR114","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1172\/JCI0214550","volume":"109","author":"S Oyadomari","year":"2002","unstructured":"Oyadomari S (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Investig 109:525\u2013532","journal-title":"J Clin Investig"},{"key":"8_CR115","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","volume":"313","author":"U \u00d6zcan","year":"2006","unstructured":"\u00d6zcan U, Yilmaz E, \u00d6zcan L, Furuhashi M, Vaillancourt E, Smith RO, G\u00f6rg\u00fcn CZ, Hotamisligil GS (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137\u20131140","journal-title":"Science"},{"key":"8_CR116","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/1078-0432.CCR-11-2186","volume":"18","author":"D Paez","year":"2012","unstructured":"Paez D, Labonte MJ, Bohanes P, Zhang W, Benhanim L, Ning Y, Wakatsuki T, Loupakis F, Lenz HJ (2012) Cancer dormancy: a model of early dissemination and late cancer recurrence. Clin Cancer Res 18:645\u2013653","journal-title":"Clin Cancer Res"},{"key":"8_CR117","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/ncb2868","volume":"15","author":"X Pan","year":"2013","unstructured":"Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA et al (2013) The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol 15:1464\u20131472","journal-title":"Nat Cell Biol"},{"key":"8_CR118","doi-asserted-by":"crossref","first-page":"pii: e37168","DOI":"10.7554\/eLife.37168","volume":"7","author":"R Paxman","year":"2018","unstructured":"Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW (2018) Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife 7:pii: e37168","journal-title":"Elife"},{"key":"8_CR119","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V97.3.685","volume":"97","author":"SW Pipe","year":"2001","unstructured":"Pipe SW, Saenko EL, Eickhorst AN, Kemball-Cook G, Kaufman RJ (2001) Hemophilia A mutations associated with 1-stage\/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa. Blood 97:685","journal-title":"Blood"},{"key":"8_CR120","doi-asserted-by":"crossref","first-page":"pii: e15550","DOI":"10.7554\/eLife.15550","volume":"5","author":"L Plate","year":"2016","unstructured":"Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5:pii: e15550","journal-title":"Elife"},{"key":"8_CR121","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1158\/0008-5472.CAN-12-3989","volume":"73","author":"O Pluquet","year":"2013","unstructured":"Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G et al (2013) Posttranscriptional regulation of PER1 underlies the oncogenic function of IRE\u03b1. Cancer Res 73:4732","journal-title":"Cancer Res"},{"key":"8_CR122","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1158\/0008-5472.CAN-07-0625","volume":"67","author":"P Pyrko","year":"2007","unstructured":"Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS (2007) The unfolded protein response regulator GRP78\/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 67:9809\u20139816","journal-title":"Cancer Res"},{"key":"8_CR123","doi-asserted-by":"crossref","first-page":"15149","DOI":"10.1073\/pnas.211566398","volume":"98","author":"S Ramaswamy","year":"2001","unstructured":"Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP et al (2001) Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A 98:15149\u201315154","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR124","doi-asserted-by":"crossref","first-page":"20915","DOI":"10.1074\/jbc.M212328200","volume":"278","author":"RK Reddy","year":"2003","unstructured":"Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS (2003) Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 278:20915\u201320924","journal-title":"J Biol Chem"},{"key":"8_CR125","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/cdd.2017.58","volume":"24","author":"D Rojas-Rivera","year":"2017","unstructured":"Rojas-Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P, Bertrand MJM (2017) When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death Differ 24:1100\u20131110","journal-title":"Cell Death Differ"},{"key":"8_CR126","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1073\/pnas.1210633110","volume":"110","author":"KM Rouschop","year":"2013","unstructured":"Rouschop KM, Dubois LJ, Keulers TG, van den Beucken T, Lambin P, Bussink J, van der Kogel AJ, Koritzinsky M, Wouters BG (2013) PERK\/eIF2alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. Proc Natl Acad Sci U S A 110:4622\u20134627","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR127","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.4161\/cc.8.23.10086","volume":"8","author":"T Rzymski","year":"2009","unstructured":"Rzymski T, Milani M, Singleton DC, Harris AL (2009) Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell Cycle 8:3838\u20133847","journal-title":"Cell Cycle"},{"key":"8_CR128","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1242993","volume":"342","author":"Y Sancak","year":"2013","unstructured":"Sancak Y, Markhard AL, Kitami T, Kovacs-Bogdan E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA et al (2013) EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342:1379\u20131382","journal-title":"Science"},{"key":"8_CR129","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.phrs.2017.02.018","volume":"119","author":"C Sarvani","year":"2017","unstructured":"Sarvani C, Sireesh D, Ramkumar KM (2017) Unraveling the role of ER stress inhibitors in the context of metabolic diseases. Pharmacol Res 119:412\u2013421","journal-title":"Pharmacol Res"},{"key":"8_CR130","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","volume":"7","author":"D Scheuner","year":"2001","unstructured":"Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ (2001) Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 7:1165\u20131176","journal-title":"Mol Cell"},{"key":"8_CR131","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm1259","volume":"11","author":"D Scheuner","year":"2005","unstructured":"Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ (2005) Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med 11:757\u2013764","journal-title":"Nat Med"},{"key":"8_CR132","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1073\/pnas.0800939105","volume":"105","author":"DM Schewe","year":"2008","unstructured":"Schewe DM, Aguirre-Ghiso JA (2008) ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A 105:10519\u201310524","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR133","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/77770","volume":"1","author":"H Schild","year":"2000","unstructured":"Schild H, Rammensee HG (2000) gp96\u00a0\u2013 the immune system\u2019s Swiss army knife. Nat Immunol 1:100\u2013101","journal-title":"Nat Immunol"},{"key":"8_CR134","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molcel.2017.12.028","volume":"69","author":"D Sepulveda","year":"2018","unstructured":"Sepulveda D, Rojas-Rivera D, Rodriguez DA, Groenendyk J, Kohler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y et al (2018) Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1alpha. Mol Cell 69:238\u2013252.e7","journal-title":"Mol Cell"},{"key":"8_CR135","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature24302","volume":"551","author":"S Shalapour","year":"2017","unstructured":"Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T et al (2017) Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551:340\u2013345","journal-title":"Nature"},{"key":"8_CR136","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","volume":"3","author":"J Shen","year":"2002","unstructured":"Shen J, Chen X, Hendershot L, Prywes R (2002) ER Stress Regulation of ATF6 Localization by Dissociation of BiP\/GRP78 Binding and Unmasking of Golgi Localization Signals. Dev Cell 3:99\u2013111","journal-title":"Dev Cell"},{"key":"8_CR137","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/mol.112.084269","volume":"84","author":"R Shimozono","year":"2013","unstructured":"Shimozono R, Asaoka Y, Yoshizawa Y, Aoki T, Noda H, Yamada M, Kaino M, Mochizuki H (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol 84:62\u201370","journal-title":"Mol Pharmacol"},{"key":"8_CR138","doi-asserted-by":"crossref","first-page":"e05033","DOI":"10.7554\/eLife.05033","volume":"4","author":"C Sidrauski","year":"2015","unstructured":"Sidrauski C, McGeachy AM, Ingolia NT, Walter P (2015) The small molecule ISRIB reverses the effects of eIF2alpha phosphorylation on translation and stress granule assembly. Elife 4:e05033","journal-title":"Elife"},{"key":"8_CR139","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI34587","volume":"118","author":"B Song","year":"2008","unstructured":"Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ (2008) Chop deletion reduces oxidative stress, improves \u03b2 cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118:3378\u20133389","journal-title":"J Clin Invest"},{"key":"8_CR140","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1523\/JNEUROSCI.1118-15.2016","volume":"36","author":"CM Southwood","year":"2016","unstructured":"Southwood CM, Fykkolodziej B, Maheras KJ, Garshott DM, Estill M, Fribley AM, Gow A (2016) Overexpression of CHOP in myelinating cells does not confer a significant phenotype under normal or metabolic stress conditions. J Neurosci 36:6803\u20136819","journal-title":"J Neurosci"},{"key":"8_CR141","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.18632\/oncotarget.7702","volume":"7","author":"H Sun","year":"2016","unstructured":"Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R et al (2016) Inhibition of IRE1alpha-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget 7:18736\u201318749","journal-title":"Oncotarget"},{"key":"8_CR142","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ajhg.2014.10.013","volume":"95","author":"M Synofzik","year":"2014","unstructured":"Synofzik M, Haack TB, Kopajtich R, Gorza M, Rapaport D, Greiner M, Schonfeld C, Freiberg C, Schorr S, Holl RW et al (2014) Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration. Am J Hum Genet 95:689\u2013697","journal-title":"Am J Hum Genet"},{"key":"8_CR143","doi-asserted-by":"crossref","first-page":"pii: eaaq0939","DOI":"10.1126\/science.aaq0939","volume":"359","author":"JC Tsai","year":"2018","unstructured":"Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P (2018) Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:pii: eaaq0939","journal-title":"Science"},{"key":"8_CR144","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1201396","volume":"332","author":"P Tsaytler","year":"2011","unstructured":"Tsaytler P, Harding HP, Ron D, Bertolotti A (2011) Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis. Science 332:91","journal-title":"Science"},{"key":"8_CR145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200311055","volume":"164","author":"BP Tu","year":"2004","unstructured":"Tu BP, Weissman JS (2004) Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164:341\u2013346","journal-title":"J Cell Biol"},{"key":"8_CR146","doi-asserted-by":"crossref","first-page":"E1395","DOI":"10.1073\/pnas.1621188114","volume":"114","author":"O Tufanli","year":"2017","unstructured":"Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Cimen I, Walter P, Weber C, Erbay E (2017) Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A 114:E1395\u2013E1404","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8_CR147","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","volume":"29","author":"A Umemura","year":"2016","unstructured":"Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A et al (2016) p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29:935\u2013948","journal-title":"Cancer Cell"},{"key":"8_CR148","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","volume":"287","author":"F Urano","year":"2000","unstructured":"Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664","journal-title":"Science"},{"key":"8_CR149","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12072-014-9582-0","volume":"9","author":"Y-P Vandewynckel","year":"2015","unstructured":"Vandewynckel Y-P, Laukens D, Bogaerts E, Paridaens A, Van den Bussche A, Verhelst X, Van Steenkiste C, Descamps B, Vanhove C, Libbrecht L et al (2015) Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy. Hepatol Int 9:93\u2013104","journal-title":"Hepatol Int"},{"key":"8_CR150","doi-asserted-by":"crossref","first-page":"15602","DOI":"10.1038\/srep15602","volume":"5","author":"M Waldeck-Weiermair","year":"2015","unstructured":"Waldeck-Weiermair M, Malli R, Parichatikanond W, Gottschalk B, Madreiter-Sokolowski CT, Klec C, Rost R, Graier WF (2015) Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). Sci Rep 5:15602","journal-title":"Sci Rep"},{"key":"8_CR151","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrc3800","volume":"14","author":"M Wang","year":"2014","unstructured":"Wang M, Kaufman RJ (2014) The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat Rev Cancer 14:581\u2013597","journal-title":"Nat Rev Cancer"},{"key":"8_CR152","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","volume":"529","author":"M Wang","year":"2016","unstructured":"Wang M, Kaufman RJ (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529:326\u2013335","journal-title":"Nature"},{"key":"8_CR153","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1093\/emboj\/17.13.3619","volume":"17","author":"XZ Wang","year":"1998","unstructured":"Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, Zinszner H, Ron D (1998) Identification of novel stress-induced genes downstream of chop. EMBO J 17:3619\u20133630","journal-title":"EMBO J"},{"key":"8_CR154","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nchembio.1094","volume":"8","author":"L Wang","year":"2012","unstructured":"Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schurer SC, Oakes SA, Papa FR, Maly DJ (2012) Divergent allosteric control of the IRE1alpha endoribonuclease using kinase inhibitors. Nat Chem Biol 8:982\u2013989","journal-title":"Nat Chem Biol"},{"key":"8_CR155","doi-asserted-by":"crossref","first-page":"pii: e42940","DOI":"10.7554\/eLife.42940","volume":"8","author":"YL Wong","year":"2019","unstructured":"Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND et al (2019) eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife 8:pii: e42940","journal-title":"Elife"},{"key":"8_CR156","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.devcel.2007.07.005","volume":"13","author":"J Wu","year":"2007","unstructured":"Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ (2007) ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell 13:351\u2013364","journal-title":"Dev Cell"},{"key":"8_CR157","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.devcel.2015.12.030","volume":"36","author":"J Yong","year":"2016","unstructured":"Yong J, Itkin-Ansari P, Kaufman RJ (2016) When less is better: ER stress and beta cell proliferation. Dev Cell 36:4\u20136","journal-title":"Dev Cell"},{"key":"8_CR158","doi-asserted-by":"crossref","first-page":"pii: e49682","DOI":"10.7554\/eLife.49682","volume":"8","author":"J Yong","year":"2019","unstructured":"Yong J, Bischof H, Siirin M, Murphy A, Malli R, Kaufman RJ (2019) Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+. Elife 8:pii: e49682","journal-title":"Elife"},{"key":"8_CR159","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.aar5129","volume":"359","author":"AF Zyryanova","year":"2018","unstructured":"Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C et al (2018) Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science 359:1533","journal-title":"Science"}],"container-title":["Advances in Experimental Medicine and Biology","HSF1 and Molecular Chaperones in Biology and Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-40204-4_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T23:37:46Z","timestamp":1615246666000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-40204-4_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030402037","9783030402044"],"references-count":159,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-40204-4_8","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"16 April 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}