{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T15:08:00Z","timestamp":1743088080857,"version":"3.40.3"},"publisher-location":"Cham","reference-count":13,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030410315"},{"type":"electronic","value":"9783030410322"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-41032-2_4","type":"book-chapter","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T22:02:28Z","timestamp":1581631348000},"page":"40-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal Control Problem of a Metronomic Chemotherapy"],"prefix":"10.1007","author":[{"given":"Dieter","family":"Grass","sequence":"first","affiliation":[]},{"given":"Valeriya","family":"Lykina","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"4_CR1","first-page":"1878","volume":"60","author":"T Browder","year":"2000","unstructured":"Browder, T., et al.: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60, 1878\u20131886 (2000)","journal-title":"Cancer Res."},{"key":"4_CR2","volume-title":"Linear Operators. Part I: General Theory","author":"N Dunford","year":"1988","unstructured":"Dunford, N., Schwartz, J.T.: Linear Operators. Part I: General Theory. Wiley-Interscience, New York (1988)"},{"key":"4_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-08528-8","volume-title":"Ma\u00df und Integrationstheorie","author":"J Elstrodt","year":"1996","unstructured":"Elstrodt, J.: Ma\u00df und Integrationstheorie. Springer, Berlin (1996). https:\/\/doi.org\/10.1007\/978-3-662-08528-8"},{"issue":"10","key":"4_CR4","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.jedc.2012.04.006","volume":"36","author":"D Gra\u00df","year":"2012","unstructured":"Gra\u00df, D.: Numerical computation of the optimal vector field in a fishery model. J. Econ. Dyn. Control 36(10), 1626\u20131658 (2012)","journal-title":"J. Econ. Dyn. Control"},{"issue":"8","key":"4_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1172\/JCI9872","volume":"105","author":"D Hanahan","year":"2000","unstructured":"Hanahan, D., Bergers, G., Bergsland, E.: Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J. Clin. Invest. 105(8), 145\u2013147 (2000)","journal-title":"J. Clin. Invest."},{"issue":"8","key":"4_CR6","doi-asserted-by":"publisher","first-page":"R15","DOI":"10.1172\/JCI8829","volume":"105","author":"G Klement","year":"2000","unstructured":"Klement, G., et al.: Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without over toxicity. J. Clin. Invest. 105(8), R15\u2013R24 (2000)","journal-title":"J. Clin. Invest."},{"key":"4_CR7","volume-title":"Weighted Sobolev Spaces","author":"A Kufner","year":"1985","unstructured":"Kufner, A.: Weighted Sobolev Spaces. Wiley, Chichester (1985)"},{"issue":"4","key":"4_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1051\/mmnp\/20149409","volume":"9","author":"U Ledzewicz","year":"2014","unstructured":"Ledzewicz, U., Sch\u00e4ttler, H.: A review of optimal chemotherapy protocols: from MTD towards metronomic therapy. J. Math. Model. Nat. Phenom. 9(4), 131\u2013152 (2014)","journal-title":"J. Math. Model. Nat. Phenom."},{"issue":"1","key":"4_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jmaa.2017.04.069","volume":"454","author":"V Lykina","year":"2017","unstructured":"Lykina, V., Pickenhain, S.: Weighted functional spaces approach in infinite horizon optimal control problems: a systematic analysis of hidden advantages and opportunities. J. Math. Anal. Appl. 454(1), 195\u2013218 (2017)","journal-title":"J. Math. Anal. Appl."},{"key":"4_CR10","series-title":"An Application of Geometric Methods, Interdisciplinary Applied Mathematics","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2972-6","volume-title":"Optimal Control for Mathematical Models of Cancer Therapies","author":"H Sch\u00e4ttler","year":"2015","unstructured":"Sch\u00e4ttler, H., Ledzewicz, U.: Optimal Control for Mathematical Models of Cancer Therapies. An Application of Geometric Methods, Interdisciplinary Applied Mathematics, vol. 42. Springer, New York (2015). https:\/\/doi.org\/10.1007\/978-1-4939-2972-6"},{"key":"4_CR11","unstructured":"Valdez, E.A.: Survival models (2014). https:\/\/studylib.net\/doc\/8854157\/survival-models"},{"key":"4_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-96208-0","volume-title":"Functional Analysis","author":"K Yosida","year":"1974","unstructured":"Yosida, K.: Functional Analysis. Springer, New York (1974)"},{"key":"4_CR13","unstructured":"Pasquier, E., Ledzewicz, U.: More is not necessarily better: metronomic chemotherapy. Newslett. Soc. Math. Biol. 26(2) (2013)"}],"container-title":["Lecture Notes in Computer Science","Large-Scale Scientific Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-41032-2_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T16:24:41Z","timestamp":1607531081000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-41032-2_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030410315","9783030410322"],"references-count":13,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-41032-2_4","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"13 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"LSSC","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Large-Scale Scientific Computing","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Sozopol","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Bulgaria","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2019","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10 June 2019","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"14 June 2019","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"12","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"lssc2019","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/parallel.bas.bg\/Conferences\/SciCom19\/index.html","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}