{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:04:20Z","timestamp":1790525060468,"version":"4.1.0"},"publisher-location":"Cham","reference-count":43,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030482367","type":"print"},{"value":"9783030482381","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-48238-1_27","type":"book-chapter","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T17:04:33Z","timestamp":1620493473000},"page":"169-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Warburg Effect: Historical Dogma Versus Current Rationale"],"prefix":"10.1007","author":[{"given":"Peter","family":"Vaupel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Multhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,9]]},"reference":[{"key":"27_CR1","first-page":"317","volume":"142","author":"O Warburg","year":"1923","unstructured":"Warburg O (1923) Versuche an \u00fcberlebendem Carcinomgewebe. Biochem Zschr 142:317\u2013333","journal-title":"Biochem Zschr"},{"key":"27_CR2","first-page":"319","volume":"152","author":"O Warburg","year":"1924","unstructured":"Warburg O, Posener K, Negelein E (1924) \u00dcber den Stoffwechsel der Carcinomzelle. Biochem Zschr 152:319\u2013344","journal-title":"Biochem Zschr"},{"key":"27_CR3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","volume":"124","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the respiratory impairment in cancer cells. Science 124:269\u2013270","journal-title":"Science"},{"key":"27_CR4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","volume":"95","author":"P Vaupel","year":"2019","unstructured":"Vaupel P, Schmidberger H, Mayer A (2019) The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression. Int J Radiat Biol 95:912\u2013919","journal-title":"Int J Radiat Biol"},{"key":"27_CR5","first-page":"377","volume":"166","author":"P Vaupel","year":"1990","unstructured":"Vaupel P (1990) Oxygenation of human tumors. Strahlenther Onkol 166:377\u2013386","journal-title":"Strahlenther Onkol"},{"key":"27_CR6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.semradonc.2004.04.008","volume":"14","author":"P Vaupel","year":"2004","unstructured":"Vaupel P (2004) Tumor microenvironmental physiology and its implication for radiation oncology. Semin Radiat Oncol 14:198\u2013206","journal-title":"Semin Radiat Oncol"},{"key":"27_CR7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956) On the origin of cancer cells. Science 123:309\u2013314","journal-title":"Science"},{"key":"27_CR8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.2164-0947.1953.tb01322.x","volume":"16","author":"B Chance","year":"1953","unstructured":"Chance B (1953) Dynamics of respiratory pigments of ascites tumor cells. Trans N Y Acad Sci 16:74\u201375","journal-title":"Trans N Y Acad Sci"},{"key":"27_CR9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.116.3008.200","volume":"116","author":"B Chance","year":"1952","unstructured":"Chance B, Castor NL (1952) Some patterns of the respiratory pigments of ascites tumors of mice. Science 116:200\u2013202","journal-title":"Science"},{"key":"27_CR10","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1749-6632.1956.tb50908.x","volume":"63","author":"B Chance","year":"1956","unstructured":"Chance B, Hess B (1956) On the control of metabolism in ascites tumor cell suspensions. Ann N Y Acad Sci 63:1008\u20131016","journal-title":"Ann N Y Acad Sci"},{"key":"27_CR11","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0021-9258(18)69827-8","volume":"234","author":"B Chance","year":"1959","unstructured":"Chance B, Hess B (1959) Metabolic control mechanisms. III. Kinetics of oxygen utilization in ascites tumor cells. J Biol Chem 234:2416\u20132427","journal-title":"J Biol Chem"},{"key":"27_CR12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1126\/science.124.3215.267","volume":"124","author":"S Weinhouse","year":"1956","unstructured":"Weinhouse S (1956) On respiratory impairment in cancer cells. Science 124:267\u2013269","journal-title":"Science"},{"key":"27_CR13","first-page":"115","volume":"87","author":"S Weinhouse","year":"1976","unstructured":"Weinhouse S (1976) The Warburg hypothesis fifty years later. Cancer Res Clin Oncol 87:115\u2013126","journal-title":"Cancer Res Clin Oncol"},{"key":"27_CR14","volume-title":"The glycolysis and respiration of tumors","author":"AC Aisenberg","year":"1961","unstructured":"Aisenberg AC (1961) The glycolysis and respiration of tumors. Academic Press, New York"},{"key":"27_CR15","first-page":"1","volume":"1","author":"P Vaupel","year":"1974","unstructured":"Vaupel P (1974) Atemgaswechsel und Glucosestoffwechsel von Implantationstumoren (DS-Carcinosarkom) in vivo. Funktionsanalyse Biolog Systeme 1:1\u2013138","journal-title":"Funktionsanalyse Biolog Systeme"},{"key":"27_CR16","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.biocel.2012.05.019","volume":"44","author":"P Vaupel","year":"2012","unstructured":"Vaupel P, Mayer A (2012) Availability, not respiratory capacity governs oxygen consumption in solid tumors. Int J Biochem Cell Biol 44:1477\u20131481","journal-title":"Int J Biochem Cell Biol"},{"key":"27_CR17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"RA Gatenby","year":"2004","unstructured":"Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891\u2013899","journal-title":"Nat Rev Cancer"},{"key":"27_CR18","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674","journal-title":"Cell"},{"key":"27_CR19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029\u20131033","journal-title":"Science"},{"key":"27_CR20","first-page":"3835","volume":"118","author":"GL Semenza","year":"2008","unstructured":"Semenza GL (2008) Tumor metabolism: cancer cells give and take lactate. J Clin Invest 118:3835\u20133837","journal-title":"J Clin Invest"},{"key":"27_CR21","first-page":"3930","volume":"118","author":"P Sonveaux","year":"2008","unstructured":"Sonveaux P, Vegran F, Schroeder T et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930\u20133942","journal-title":"J Clin Invest"},{"key":"27_CR22","doi-asserted-by":"crossref","first-page":"57813","DOI":"10.18632\/oncotarget.18175","volume":"8","author":"Y Fu","year":"2017","unstructured":"Fu Y, Liu S, Yin S et al (2017) The reverse Warburg effect is likely to be an Achilles heel of cancer that can be exploited for cancer therapy. Oncotarget 8:57813\u201357825","journal-title":"Oncotarget"},{"key":"27_CR23","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","volume":"8","author":"S Pavlides","year":"2009","unstructured":"Pavlides S, Whitaker-Menezes D, Castello-Cros R et al (2009) The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8:3984\u20134001","journal-title":"Cell Cycle"},{"key":"27_CR24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/nbm.1940050505","volume":"5","author":"P Vaupel","year":"1992","unstructured":"Vaupel P (1992) Physiological properties of malignant tumours. NMR Biomed 5:220\u2013225","journal-title":"NMR Biomed"},{"key":"27_CR25","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1096\/fj.00-0823hyp","volume":"15","author":"M Kirsch","year":"2001","unstructured":"Kirsch M, De Groot H (2001) NAD(P)H, a directly operating antioxidant? FASEB J 15:1569\u20131574","journal-title":"FASEB J"},{"key":"27_CR26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcell.2019.00004","volume":"7","author":"WA Tameemi","year":"2019","unstructured":"Tameemi WA, Dale TP, Al-Jumaily RMK et al (2019) Hypoxia-modified cancer cell metabolism. Front Cell Dev Biol 7:4","journal-title":"Front Cell Dev Biol"},{"key":"27_CR27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","volume":"20","author":"GL Semenza","year":"2010","unstructured":"Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51\u201356","journal-title":"Curr Opin Genet Dev"},{"key":"27_CR28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/ijms20020238","volume":"20","author":"A Nagao","year":"2019","unstructured":"Nagao A, Kobayashi M, Koyasu S et al (2019) HIF-1 dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance. Int J Mol Sci 20:238","journal-title":"Int J Mol Sci"},{"key":"27_CR29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jdsr.2017.08.003","volume":"54","author":"Y Kato","year":"2018","unstructured":"Kato Y, Maeda T, Suzuki A et al (2018) Cancer metabolism: new insights into classic characteristics. Jpn Dent Sci Rev 54:8\u201321","journal-title":"Jpn Dent Sci Rev"},{"key":"27_CR30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","volume":"356","author":"J Lu","year":"2015","unstructured":"Lu J, Tan M, Cai Q (2015) The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett 356:156\u2013164","journal-title":"Cancer Lett"},{"key":"27_CR31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/10409238.2018.1556578","volume":"53","author":"S Ganapathy-Kanniappan","year":"2019","unstructured":"Ganapathy-Kanniappan S (2019) Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype. Crit Rev Biochem Mol Biol 53:667\u2013682","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"27_CR32","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1158\/2159-8290.CD-12-0345","volume":"2","author":"JR Cantor","year":"2012","unstructured":"Cantor JR, Sabatini DM (2012) Cancer cell metabolism: one hallmark, many faces. Cancer Discov 2:881\u2013898","journal-title":"Cancer Discov"},{"key":"27_CR33","doi-asserted-by":"publisher","unstructured":"He X, Li C, Ke R et al (2017) Down-regulation of adenosine monophosphate-activated protein kinase activity: a driver of cancer. Tumor Biol. https:\/\/doi.org\/10.1177\/1010428317697576","DOI":"10.1177\/1010428317697576"},{"key":"27_CR34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5487\/TR.2016.32.3.177","volume":"32","author":"Q Tran","year":"2016","unstructured":"Tran Q, Lee H, Park J (2016) Targeting cancer metabolism-revisiting the Warburg effect. Toxicol Res 32:177\u2013193","journal-title":"Toxicol Res"},{"key":"27_CR35","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.1021\/acs.chemrev.7b00775","volume":"118","author":"JL Counihan","year":"2018","unstructured":"Counihan JL, Grossman EA, Nomura DK (2018) Cancer metabolism: current understanding and therapies. Chem Rev 118:6893\u20136923","journal-title":"Chem Rev"},{"key":"27_CR36","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.7150\/jca.21125","volume":"8","author":"L Yu","year":"2017","unstructured":"Yu L, Chen X, Sun X et al (2017) The glycolytic switch in tumors: how many players are involved? J Cancer 8:3430\u20133440","journal-title":"J Cancer"},{"key":"27_CR37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fphar.2012.00022","volume":"3","author":"B Martinez-Pastor","year":"2012","unstructured":"Martinez-Pastor B, Mostolavsky R (2012) Sirtuins, metabolism, and cancer. Front Pharmacol 3:22","journal-title":"Front Pharmacol"},{"key":"27_CR38","doi-asserted-by":"crossref","unstructured":"San-Millan I, Brooks GA (2017) Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect. Carcinogenesis 38:119\u2013133","DOI":"10.1093\/carcin\/bgw127"},{"key":"27_CR39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4614-7411-1_28","volume":"789","author":"A Mayer","year":"2013","unstructured":"Mayer A, Vaupel P (2013) Hypoxia, lactate accumulation and acidosis: siblings or accomplices driving tumor progression and resistance to therapy. Adv Exp Med Biol 789:203\u2013209","journal-title":"Adv Exp Med Biol"},{"key":"27_CR40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-3-319-91287-5_27","volume":"1072","author":"P Vaupel","year":"2018","unstructured":"Vaupel P, Multhoff G (2018) Hypoxia-\/HIF-1\u03b1-driven factors of the tumor microenvironment impeding antitumor immune responses and promoting malignant progression. Adv Exp Med Biol 1072:171\u2013176","journal-title":"Adv Exp Med Biol"},{"key":"27_CR41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10555-018-09777-y","volume":"38","author":"O Thews","year":"2019","unstructured":"Thews O, Riemann A (2019) Tumor pH and metastasis: a malignant process beyond hypoxia. Cancer Metastasis Rev 38:113\u2013129","journal-title":"Cancer Metastasis Rev"},{"key":"27_CR42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrc.2017.77","volume":"17","author":"C Corbet","year":"2017","unstructured":"Corbet C, Feron O (2017) Tumour acidosis: from the passenger to the driver\u2019s seat. Nat Rev Cancer 17:577\u2013593","journal-title":"Nat Rev Cancer"},{"key":"27_CR43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-4939-3023-4_27","volume":"876","author":"A Riemann","year":"2016","unstructured":"Riemann A, Schneider B, G\u00fcndel D et al (2016) Acidosis promotes metastasis formation by enhancing tumor cell motility. Adv Exp Med Biol 876:215\u2013220","journal-title":"Adv Exp Med Biol"}],"updated-by":[{"DOI":"10.1007\/978-3-030-48238-1_64","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000}}],"container-title":["Advances in Experimental Medicine and Biology","Oxygen Transport to Tissue XLII"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-48238-1_27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T17:07:54Z","timestamp":1730135274000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-48238-1_27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030482367","9783030482381"],"references-count":43,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-48238-1_27","relation":{"retraction":[{"id-type":"doi","id":"10.1007\/978-3-030-48238-1_64","asserted-by":"object"}]},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"9 May 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"10 January 2023","order":2,"name":"change_date","label":"Change Date","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"\u201cThe original version of this <b>chapter 27[\u201cThe Warburg Effect: Historical Dogma Versus Current Rationale\u201d]<\/b> has been retracted.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}