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In seven piglet preclinical models of neonatal HI, we measured cerebral tissue saturation (StO<jats:sub>2<\/jats:sub>), cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO<jats:sub>2<\/jats:sub>), changes in the mitochondrial oxidation state of cytochrome c oxidase (oxCCO), cerebral glucose metabolism (CMRglc) and tissue biochemistry (Lac+Thr\/tNAA). At baseline, the parameters measured in the piglets that experience HI (not controls) were 64\u00a0\u00b1\u00a06% StO<jats:sub>2<\/jats:sub>, 35\u00a0\u00b1\u00a011\u00a0ml\/100\u00a0g\/min CBF and 2.0\u00a0\u00b1\u00a00.4\u00a0\u03bcmol\/100\u00a0g\/min CMRO2. After HI, the parameters measured were 68\u00a0\u00b1\u00a06% StO<jats:sub>2<\/jats:sub>, 35\u00a0\u00b1\u00a06\u00a0ml\/100\u00a0g\/min CBF, 1.3\u00a0\u00b1\u00a00.1\u00a0\u03bcmol\/100\u00a0g\/min CMRO<jats:sub>2<\/jats:sub>, 0.4\u00a0\u00b1\u00a00.2 Lac+Thr\/tNAA and 9.5\u00a0\u00b1\u00a02.0 CMRglc. This study demonstrates the capacity of a multimodal set-up to interrogate the pathophysiology of HIE using a combination of optical methods, MRS, and PET.<\/jats:p>","DOI":"10.1007\/978-3-030-48238-1_32","type":"book-chapter","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T17:04:33Z","timestamp":1620493473000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multimodal Measurements of Brain Tissue Metabolism and Perfusion in a Neonatal Model of Hypoxic-Ischaemic Injury"],"prefix":"10.1007","author":[{"given":"Gemma","family":"Bale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Rajaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bainbridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udunna","family":"Anazodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou","family":"Diop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith St","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Tachtsidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,9]]},"reference":[{"key":"32_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pediatrneurol.2015.11.010","volume":"55","author":"LF Chalak","year":"2016","unstructured":"Chalak LF, Tian F, Tarumi T, Zhang R (2016) Cerebral hemodynamics in asphyxiated newborns undergoing hypothermia therapy: pilot findings using a multiple-time-scale analysis. 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