{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:55:45Z","timestamp":1790268945649,"version":"4.1.0"},"publisher-location":"Cham","reference-count":72,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030561529","type":"print"},{"value":"9783030561536","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-56153-6_19","type":"book-chapter","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T12:02:37Z","timestamp":1627732957000},"page":"327-343","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Use of Curcumin for the Treatment of Renal Disorders: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.1007","author":[{"given":"Mohammad","family":"Bagherniya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Rouhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"issue":"7","key":"19_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158765","volume":"11","author":"NR Hill","year":"2016","unstructured":"Hill NR, Fatoba ST, Oke JL, Hirst JA, O\u2019Callaghan CA, Lasserson DS et al (2016) Global prevalence of chronic kidney disease\u2013a systematic review and meta-analysis. PLoS One 11(7):e0158765. https:\/\/doi.org\/10.1371\/journal.pone.0158765","journal-title":"PLoS One"},{"issue":"5","key":"19_CR2","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1159\/000338135","volume":"35","author":"T Etgen","year":"2012","unstructured":"Etgen T, Chonchol M, Forstl H, Sander D (2012) Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis. Am J Nephrol 35(5):474\u2013482","journal-title":"Am J Nephrol"},{"issue":"4","key":"19_CR3","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1053\/j.ajkd.2004.12.021","volume":"45","author":"RL Perlman","year":"2005","unstructured":"Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G et al (2005) Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis 45(4):658\u2013666","journal-title":"Am J Kidney Dis"},{"issue":"9889","key":"19_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","volume":"382","author":"RT Gansevoort","year":"2013","unstructured":"Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJ, Mann JF et al (2013) Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 382(9889):339\u2013352","journal-title":"Lancet"},{"issue":"3","key":"19_CR5","first-page":"418","volume":"15","author":"C Alebiosu","year":"2005","unstructured":"Alebiosu C, Ayodele O (2005) The global burden of chronic kidney disease and the way forward. Ethn Dis 15(3):418","journal-title":"Ethn Dis"},{"key":"19_CR6","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1111\/j.1523-1755.2005.09403.x","volume":"67","author":"RC Atkins","year":"2005","unstructured":"Atkins RC (2005) The epidemiology of chronic kidney disease. Kidney Int 67:S14\u2013S18","journal-title":"Kidney Int"},{"issue":"1","key":"19_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","volume":"25","author":"P Dandona","year":"2004","unstructured":"Dandona P, Aljada A, Bandyopadhyay A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25(1):4\u20137","journal-title":"Trends Immunol"},{"issue":"2","key":"19_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.amjcard.2005.11.010","volume":"97","author":"SM Haffner","year":"2006","unstructured":"Haffner SM (2006) The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. Am J Cardiol 97(2):3\u201311","journal-title":"Am J Cardiol"},{"issue":"12","key":"19_CR9","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1253\/circj.CJ-11-1184","volume":"75","author":"I Manabe","year":"2011","unstructured":"Manabe I (2011) Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 75(12):2739\u20132748","journal-title":"Circ J"},{"key":"19_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.coi.2014.03.007","volume":"29","author":"G Pawelec","year":"2014","unstructured":"Pawelec G, Goldeck D, Derhovanessian E (2014) Inflammation, ageing and chronic disease. Curr Opin Immunol 29:23\u201328","journal-title":"Curr Opin Immunol"},{"issue":"1\u20133","key":"19_CR11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000368940","volume":"39","author":"M Akchurin","year":"2015","unstructured":"Akchurin M, Kaskel F (2015) Update on inflammation in chronic kidney disease. Blood Purif 39(1\u20133):84\u201392","journal-title":"Blood Purif"},{"issue":"6","key":"19_CR12","doi-asserted-by":"publisher","first-page":"lii","DOI":"10.1097\/01.mat.0000147958.87989.eb","volume":"50","author":"Q Yao","year":"2004","unstructured":"Yao Q, Axelsson J, Stenvinkel P, Lindholm B (2004) Chronic systemic inflammation in dialysis patients: an update on causes and consequences. ASAIO J 50(6):lii\u2013lvii. https:\/\/doi.org\/10.1097\/01.mat.0000147958.87989.eb","journal-title":"ASAIO J"},{"issue":"6","key":"19_CR13","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.2337\/db08-0057","volume":"57","author":"JM Forbes","year":"2008","unstructured":"Forbes JM, Coughlan MT, Cooper ME (2008) Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 57(6):1446\u20131454","journal-title":"Diabetes"},{"issue":"4","key":"19_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1440-1797.2012.01572.x","volume":"17","author":"DM Small","year":"2012","unstructured":"Small DM, Coombes JS, Bennett N, Johnson DW, Gobe GC (2012) Oxidative stress, anti-oxidant therapies and chronic kidney disease. Nephrology 17(4):311\u2013321","journal-title":"Nephrology"},{"issue":"5","key":"19_CR15","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1093\/ndt\/gfl839","volume":"22","author":"J Chandar","year":"2007","unstructured":"Chandar J, Abitbol C, Montane B, Zilleruelo G (2007) Angiotensin blockade as sole treatment for proteinuric kidney disease in children. Nephrol Dial Transpl 22(5):1332\u20131337","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"19_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1053\/j.ackd.2014.01.007","volume":"21","author":"RZ Alicic","year":"2014","unstructured":"Alicic RZ, Tuttle KR (2014) Novel therapies for diabetic kidney disease. Adv Chronic Kidney Dis 21(2):121\u2013133","journal-title":"Adv Chronic Kidney Dis"},{"issue":"1","key":"19_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.5527\/wjn.v4.i1.83","volume":"4","author":"V Pandya","year":"2015","unstructured":"Pandya V, Rao A, Chaudhary K (2015) Lipid abnormalities in kidney disease and management strategies. World J Nephrol 4(1):83","journal-title":"World J Nephrol"},{"issue":"2","key":"19_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5551\/jat.12849","volume":"20","author":"WF Keane","year":"2012","unstructured":"Keane WF, Tomassini JE, Neff DR (2012) Lipid abnormalities in patients with chronic kidney disease: implications for the pathophysiology of atherosclerosis. J Atheroscler Thromb 20(2):123\u2013133","journal-title":"J Atheroscler Thromb"},{"key":"19_CR19","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1046\/j.1523-1755.61.s80.18.x","volume":"61","author":"C Wanner","year":"2002","unstructured":"Wanner C, Zimmermann J, Schwedler S, Metzger T (2002) Inflammation and cardiovascular risk in dialysis patients. Kidney Int 61:S99\u2013S102","journal-title":"Kidney Int"},{"issue":"Suppl 1","key":"19_CR20","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1681\/ASN.V13suppl_1s28","volume":"13","author":"AR Qureshi","year":"2002","unstructured":"Qureshi AR, Alvestrand A, Divino-Filho JC, Gutierrez A, Heimb\u00fcrger O, Lindholm B et al (2002) Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol 13(Suppl 1):S28\u2013S36","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"19_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12944-020-01250-6","volume":"19","author":"S Talebi","year":"2020","unstructured":"Talebi S, Bagherniya M, Atkin SL, Askari G, Orafai HM, Sahebkar A (2020) The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review. Lipids Health Dis 19(1):66. https:\/\/doi.org\/10.1186\/s12944-020-01250-6","journal-title":"Lipids Health Dis"},{"key":"19_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.phrs.2017.12.020","volume":"130","author":"M Bagherniya","year":"2018","unstructured":"Bagherniya M, Nobili V, Blesso CN, Sahebkar A (2018) Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review. Pharmacol Res 130:213\u2013240","journal-title":"Pharmacol Res"},{"key":"19_CR23","doi-asserted-by":"publisher","unstructured":"Bagherniya M, Johnston TP, Sahebkar A (2020) Regulation of apolipoprotein B by natural products and nutraceuticals: a comprehensive review. Curr Med Chem. https:\/\/doi.org\/10.2174\/0929867327666200427092114. Online ahead of print","DOI":"10.2174\/0929867327666200427092114"},{"issue":"8","key":"19_CR24","doi-asserted-by":"publisher","first-page":"462","DOI":"10.5830\/CVJA-2012-025","volume":"23","author":"C Musabayane","year":"2012","unstructured":"Musabayane C (2012) The effects of medicinal plants on renal function and blood pressure in diabetes mellitus. Cardiovasc J Afr 23(8):462\u2013468","journal-title":"Cardiovasc J Afr"},{"issue":"3\u20134","key":"19_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.phymed.2009.05.020","volume":"17","author":"M Iranshahi","year":"2010","unstructured":"Iranshahi M, Sahebkar A, Hosseini ST, Takasaki M, Konoshima T, Tokuda H (2010) Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine 17(3\u20134):269\u2013273","journal-title":"Phytomedicine"},{"issue":"13","key":"19_CR26","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","volume":"57","author":"B Kocaadam","year":"2017","unstructured":"Kocaadam B, \u015eanlier N (2017) Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr 57(13):2889\u20132895","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"2","key":"19_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2174\/1567205053585882","volume":"2","author":"JM Ringman","year":"2005","unstructured":"Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL (2005) A potential role of the curry spice curcumin in Alzheimer\u2019s disease. Curr Alzheimer Res 2(2):131\u2013136","journal-title":"Curr Alzheimer Res"},{"issue":"2","key":"19_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijcard.2009.01.073","volume":"133","author":"W Wongcharoen","year":"2009","unstructured":"Wongcharoen W, Phrommintikul A (2009) The protective role of curcumin in cardiovascular diseases. Int J Cardiol 133(2):145\u2013151","journal-title":"Int J Cardiol"},{"issue":"1","key":"19_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","volume":"59","author":"H Mollazadeh","year":"2019","unstructured":"Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89\u2013101","journal-title":"Crit Rev Food Sci Nutr"},{"key":"19_CR30","doi-asserted-by":"crossref","unstructured":"Hasanzadeh S, Read MI, Bland AR, Majeed M, Jamialahmadi T, Sahebkar A (2020) Curcumin: an inflammasome silencer. Pharmacol Res 159:104921. https:\/\/doi.org\/10.1016\/j.phrs.2020.104921. Epub 2020 May 25. PMID: 32464325","DOI":"10.1016\/j.phrs.2020.104921"},{"key":"19_CR31","doi-asserted-by":"crossref","unstructured":"Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. BioFactors 43(3):331\u2013346","DOI":"10.1002\/biof.1344"},{"key":"19_CR32","doi-asserted-by":"crossref","unstructured":"Mohajeri M, Bianconi V, \u00c1vila-Rodriguez MF, Barreto GE, Jamialahmadi T, Pirro M, Sahebkar A (2020)\u00a0Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res 156:104765. https:\/\/doi.org\/10.1016\/j.phrs.2020.104765. Epub 2020 Mar 23. PMID: 32217147","DOI":"10.1016\/j.phrs.2020.104765"},{"issue":"2","key":"19_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/biof.1062","volume":"39","author":"A Sahebkar","year":"2013","unstructured":"Sahebkar A (2013) Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? BioFactors 39(2):197\u2013208","journal-title":"BioFactors"},{"issue":"4","key":"19_CR34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s40291-016-0202-7","volume":"20","author":"AA Momtazi","year":"2016","unstructured":"Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther 20(4):335\u2013345","journal-title":"Mol Diagn Ther"},{"issue":"28","key":"19_CR35","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.2174\/1381612822666160527113501","volume":"22","author":"AA Momtazi","year":"2016","unstructured":"Momtazi AA, Sahebkar A (2016) Difluorinated curcumin: a promising curcumin analogue with improved anti-tumor activity and pharmacokinetic profile. Curr Pharm Des 22(28):4386\u20134397","journal-title":"Curr Pharm Des"},{"key":"19_CR36","doi-asserted-by":"crossref","unstructured":"Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A (2020)\u00a0Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors. 46(1):5\u201320. https:\/\/doi.org\/10.1002\/biof.1566. Epub 2019 Oct 3. PMID: 31580521","DOI":"10.1002\/biof.1566"},{"issue":"1","key":"19_CR37","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/0886022X.2020.1751658","volume":"42","author":"SJ Huang","year":"2020","unstructured":"Huang SJ, Huang J, Yan YB, Qiu J, Tan RQ, Liu Y et al (2020) The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a\/PTEN axis. Ren Fail 42(1):350\u2013357","journal-title":"Ren Fail"},{"issue":"4","key":"19_CR38","doi-asserted-by":"publisher","first-page":"E332","DOI":"10.3390\/antiox9040332","volume":"9","author":"S Damiano","year":"2020","unstructured":"Damiano S, Andretta E, Longobardi C, Prisco F, Paciello O, Squillacioti C et al (2020) Effects of curcumin on the renal toxicity induced by Ochratoxin A in rats. Antioxidants (Basel) 9(4):E332. https:\/\/doi.org\/10.3390\/antiox9040332","journal-title":"Antioxidants (Basel)"},{"key":"19_CR39","doi-asserted-by":"publisher","unstructured":"Akomolafe SF, Olasehinde TA, Adewale OO, Ajayi OB (2020) Curcumin improves biomolecules associated with renal function and attenuates oxidative injury and histopathological changes in potassium-induced toxicity in rats. Kidney Biol Trace Elem. https:\/\/doi.org\/10.1007\/s12011-020-02113-y. Online ahead of print","DOI":"10.1007\/s12011-020-02113-y"},{"issue":"5","key":"19_CR40","first-page":"304","volume":"13","author":"M Hami","year":"2019","unstructured":"Hami M, Bigdeli A, Rajabi O, Salehi M (2019) The effect of curcumin in prevention of contrast nephropathy following coronary angiography or angioplasty in CKD patients. Iran J Kidney Dis 13(5):304\u2013309","journal-title":"Iran J Kidney Dis"},{"issue":"20","key":"19_CR41","doi-asserted-by":"publisher","first-page":"30110","DOI":"10.1016\/j.clnu.2020.03.007","volume":"S0261-5614","author":"L Alvarenga","year":"2020","unstructured":"Alvarenga L, Salarolli R, Cardozo LFMF, Santos RS, de Brito JS, Kemp JA et al (2020) Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: a pilot randomized, double-blind, controlled study. Clin Nutr S0261-5614(20):30110\u201330112. https:\/\/doi.org\/10.1016\/j.clnu.2020.03.007. Online ahead of print","journal-title":"Clin Nutr"},{"issue":"1","key":"19_CR42","first-page":"52","volume":"14","author":"GV Afshar","year":"2020","unstructured":"Afshar GV, Rasmi Y, Yagmaye P, Khadem-Ansari MH, Makhdomi K, Rasooli J (2020) The effects of nano-curcumin supplementation on serum level of hs-CRP, adhesion molecules, and lipid profiles in hemodialysis patients, a randomized controlled clinical trial. Iran J Kidney Dis 14(1):52\u201361","journal-title":"Iran J Kidney Dis"},{"issue":"4","key":"19_CR43","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264\u2013269","journal-title":"Ann Intern Med"},{"issue":"1","key":"19_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17(1):1\u201312","journal-title":"Control Clin Trials"},{"key":"19_CR45","doi-asserted-by":"crossref","unstructured":"Moher D, Cook D, Jadad A, Tugwell P, Moher M, Jones A et al (1999) Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses. Health Technol Assess 3(12):i\u2013iv., 1\u201398","DOI":"10.3310\/hta3120"},{"issue":"4","key":"19_CR46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1053\/j.jrn.2016.01.013","volume":"26","author":"AS Jim\u00e9nez-Osorio","year":"2016","unstructured":"Jim\u00e9nez-Osorio AS, Garc\u00eda-Ni\u00f1o WR, Gonz\u00e1lez-Reyes S, \u00c1lvarez-Mej\u00eda AE, Guerra-Le\u00f3n S, Salazar-Segovia J et al (2016) The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: a pilot study. J Ren Nutr 26(4):237\u2013244","journal-title":"J Ren Nutr"},{"issue":"5","key":"19_CR47","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3109\/00365599.2011.585622","volume":"45","author":"P Khajehdehi","year":"2011","unstructured":"Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH et al (2011) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-\u03b2 and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol 45(5):365\u2013370","journal-title":"Scand J Urol Nephrol"},{"issue":"1","key":"19_CR48","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1053\/j.jrn.2011.03.002","volume":"22","author":"P Khajehdehi","year":"2012","unstructured":"Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L et al (2012) Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled Study. J Ren Nutr 22(1):50\u201357","journal-title":"J Ren Nutr"},{"issue":"1","key":"19_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jcim-2012-0011","volume":"10","author":"JJ Moreillon","year":"2013","unstructured":"Moreillon JJ, Bowden RG, Deike E, Griggs J, Wilson R, Shelmadine B et al (2013) The use of an anti-inflammatory supplement in patients with chronic kidney disease. J Complement Integr Med 10(1):1\u201310","journal-title":"J Complement Integr Med"},{"key":"19_CR50","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.2147\/CIA.S223805","volume":"14","author":"BOM Ortiz","year":"2019","unstructured":"Ortiz BOM, Preciado ARF, Emiliano JR, Garza SM, Rodr\u00edguez ER, de Alba Mac\u00edas LA (2019) Recovery of bone and muscle mass in patients with chronic kidney disease and iron overload on hemodialysis and taking combined supplementation with curcumin and resveratrol. Clin Interv Aging 14:2055\u20132062","journal-title":"Clin Interv Aging"},{"issue":"1","key":"19_CR51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/hdi.12204","volume":"19","author":"M Pakfetrat","year":"2015","unstructured":"Pakfetrat M, Akmali M, Malekmakan L, Dabaghimanesh M, Khorsand M (2015) Role of turmeric in oxidative modulation in end-stage renal disease patients. Hemodial Int 19(1):124\u2013131","journal-title":"Hemodial Int"},{"issue":"2","key":"19_CR52","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s40620-014-0039-2","volume":"27","author":"M Pakfetrat","year":"2014","unstructured":"Pakfetrat M, Basiri F, Malekmakan L, Roozbeh J (2014) Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. J Nephrol 27(2):203\u2013207","journal-title":"J Nephrol"},{"key":"19_CR53","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.clnesp.2017.09.006","volume":"22","author":"F Samadian","year":"2017","unstructured":"Samadian F, Dalili N, Gholi FPR, Fattah M, Malih N, Nafar M et al (2017) Evaluation of Curcumin's effect on inflammation in hemodialysis patients. Clin Nutr ESPEN 22:19\u201323","journal-title":"Clin Nutr ESPEN"},{"key":"19_CR54","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/jrms.JRMS_1055_18","volume":"24","author":"A Vanaie","year":"2019","unstructured":"Vanaie A, Shahidi S, Iraj B, Siadat ZD, Kabirzade M, Shakiba F et al (2019) Curcumin as a major active component of turmeric attenuates proteinuria in patients with overt diabetic nephropathy. J Res Med Sci 24:77. https:\/\/doi.org\/10.4103\/jrms.JRMS_1055_18","journal-title":"J Res Med Sci"},{"key":"19_CR55","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1038\/ki.2008.516","volume":"74","author":"V Cachofeiro","year":"2008","unstructured":"Cachofeiro V, Goicochea M, De Vinuesa SG, Oubi\u00f1a P, Lahera V, Lu\u00f1o J (2008) Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease: New strategies to prevent cardiovascular risk in chronic kidney disease. Kidney Int 74:S4\u2013S9","journal-title":"Kidney Int"},{"issue":"11","key":"19_CR56","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1002\/ptr.6477","volume":"33","author":"J Hallajzadeh","year":"2019","unstructured":"Hallajzadeh J, Milajerdi A, Kolahdooz F, Amirani E, Mirzaei H, Asemi Z (2019) The effects of curcumin supplementation on endothelial function: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(11):2989\u20132995","journal-title":"Phytother Res"},{"issue":"1","key":"19_CR57","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12937-017-0293-y","volume":"16","author":"S Qin","year":"2017","unstructured":"Qin S, Huang L, Gong J, Shen S, Huang J, Ren H et al (2017) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. J Nutr 16(1):68. https:\/\/doi.org\/10.1186\/s12937-017-0293-y","journal-title":"J Nutr"},{"issue":"2","key":"19_CR58","first-page":"141","volume":"14","author":"JS Jurenka","year":"2009","unstructured":"Jurenka JS (2009) Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14(2):141\u2013153","journal-title":"Altern Med Rev"},{"issue":"3","key":"19_CR59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.intimp.2006.11.006","volume":"7","author":"L Camacho-Barquero","year":"2007","unstructured":"Camacho-Barquero L, Villegas I, S\u00e1nchez-Calvo JM, Talero E, S\u00e1nchez-Fidalgo S, Motilva V et al (2007) Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. Int Immunopharmacol 7(3):333\u2013342","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"19_CR60","first-page":"469","volume":"19","author":"JW Cho","year":"2007","unstructured":"Cho JW, Lee KS, Kim CW (2007) Curcumin attenuates the expression of IL-1\u03b2, IL-6, and TNF-\u03b1 as well as cyclin E in TNF-\u03b1-treated HaCaT cells; NF-\u03baB and MAPKs as potential upstream targets. Int J Mol Med 19(3):469\u2013474","journal-title":"Int J Mol Med"},{"issue":"4","key":"19_CR61","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.bcp.2007.08.016","volume":"75","author":"A Goel","year":"2008","unstructured":"Goel A, Kunnumakkara AB, Aggarwal BB (2008) Curcumin as \u201cCurecumin\u201d: from kitchen to clinic. Biochem Pharmacol 75(4):787\u2013809","journal-title":"Biochem Pharmacol"},{"issue":"7","key":"19_CR62","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1093\/humrep\/dep058","volume":"24","author":"YO Ilbey","year":"2009","unstructured":"Ilbey YO, Ozbek E, Cekmen M, Simsek A, Otunctemur A, Somay A (2009) Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod 24(7):1717\u20131725","journal-title":"Hum Reprod"},{"issue":"5","key":"19_CR63","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/CMR.0b013e3282ed3d0e","volume":"17","author":"YE Mar\u00edn","year":"2007","unstructured":"Mar\u00edn YE, Wall BA, Wang S, Namkoong J, Martino JJ, Suh J et al (2007) Curcumin downregulates the constitutive activity of NF-\u03baB and induces apoptosis in novel mouse melanoma cells. Melanoma Res 17(5):274\u2013283","journal-title":"Melanoma Res"},{"issue":"4","key":"19_CR64","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/carcin\/bgm248","volume":"29","author":"BE Bachmeier","year":"2008","unstructured":"Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, H\u00f6hneke C et al (2008) Curcumin downregulates the inflammatory cytokines CXCL1 and-2 in breast cancer cells via NF\u03baB. Carcinogenesis 29(4):779\u2013789","journal-title":"Carcinogenesis"},{"issue":"11","key":"19_CR65","doi-asserted-by":"publisher","first-page":"e79084","DOI":"10.1371\/journal.pone.0079084","volume":"8","author":"Y Pan","year":"2013","unstructured":"Pan Y, Zhang X, Wang Y, Cai L, Ren L, Tang L et al (2013) Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice. PLoS One 8(11):e79084. https:\/\/doi.org\/10.1371\/journal.pone.0079084. eCollection 2013","journal-title":"PLoS One"},{"issue":"9","key":"19_CR66","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1093\/carcin\/bgh165","volume":"25","author":"J Hong","year":"2004","unstructured":"Hong J, Bose M, Ju J, Ryu J-H, Chen X, Sang S et al (2004) Modulation of arachidonic acid metabolism by curcumin and related \u03b2-diketone derivatives: effects on cytosolic phospholipase A 2, cyclooxygenases and 5-lipoxygenase. Carcinogenesis 25(9):1671\u20131679","journal-title":"Carcinogenesis"},{"issue":"24","key":"19_CR67","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.3748\/wjg.v12.i24.3848","volume":"12","author":"H Jiang","year":"2006","unstructured":"Jiang H, Deng C-S, Zhang M, Xia J (2006) Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2. World J Gastroenterol 12(24):3848\u20133853","journal-title":"World J Gastroenterol"},{"key":"19_CR68","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","volume":"1282","author":"C Yang","year":"2009","unstructured":"Yang C, Zhang X, Fan H, Liu Y (2009) Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 1282:133\u2013141","journal-title":"Brain Res"},{"issue":"3","key":"19_CR69","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1042\/bj20021619","volume":"371","author":"E Balogun","year":"2003","unstructured":"Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R et al (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371(3):887\u2013895","journal-title":"Biochem J"},{"issue":"4","key":"19_CR70","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/j.1582-4934.2008.00681.x","volume":"14","author":"P Pizzo","year":"2010","unstructured":"Pizzo P, Scapin C, Vitadello M, Florean C, Gorza L (2010) Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells. J Cell Mol Med 14(4):970\u2013981","journal-title":"J Cell Mol Med"},{"issue":"1","key":"19_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/advances\/nmx011","volume":"9","author":"AL Lopresti","year":"2018","unstructured":"Lopresti AL (2018) The problem of curcumin and its bioavailability: could its gastrointestinal influence contribute to its overall health-enhancing effects? Adv Nutr 9(1):41\u201350","journal-title":"Adv Nutr"},{"issue":"6","key":"19_CR72","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807\u2013818","journal-title":"Mol Pharm"}],"container-title":["Advances in Experimental Medicine and Biology","Studies on Biomarkers and New Targets in Aging Research in Iran"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-56153-6_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T14:05:37Z","timestamp":1627740337000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-56153-6_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030561529","9783030561536"],"references-count":72,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-56153-6_19","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"1 August 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}