{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:05:12Z","timestamp":1789589112024,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":136,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030561529","type":"print"},{"value":"9783030561536","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-56153-6_2","type":"book-chapter","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T08:02:37Z","timestamp":1627718557000},"page":"15-39","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Turmeric and Curcumin: From Traditional to Modern Medicine"],"prefix":"10.1007","author":[{"given":"Maryam","family":"Akaberi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad","family":"Emami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"112177","DOI":"10.1016\/j.ejmech.2020.112177","volume":"92","author":"J Moreira","year":"2020","unstructured":"Moreira J, Saraiva L, Pinto MM, Cidade H (2020) Diarylpentanoids with antitumor activity: a critical review of structure-activity relationship studies. Eur J Med Chem 92:112177. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112177","journal-title":"Eur J Med Chem"},{"issue":"11","key":"2_CR2","doi-asserted-by":"publisher","first-page":"19320","DOI":"10.1002\/jcp.28626","volume":"234","author":"M Hatamipour","year":"2019","unstructured":"Hatamipour M, Ramezani M, Tabassi SAS, Johnston TP, Sahebkar A (2019) Demethoxycurcumin: a naturally occurring curcumin analogue for treating non-cancerous diseases. J Cell Physiol 234(11):19320\u201319330","journal-title":"J Cell Physiol"},{"key":"2_CR3","doi-asserted-by":"crossref","unstructured":"Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89\u2013101","DOI":"10.1080\/10408398.2017.1358139"},{"key":"2_CR4","doi-asserted-by":"crossref","unstructured":"Hasanzadeh S, Read MI, Bland AR, Majeed M, Jamialahmadi T, Sahebkar A (2020) Curcumin: an inflammasome silencer. Pharmacol Res 159:104921. https:\/\/doi.org\/10.1016\/j.phrs.2020.104921. Epub 2020 May 25. PMID: 32464325","DOI":"10.1016\/j.phrs.2020.104921"},{"key":"2_CR5","doi-asserted-by":"crossref","unstructured":"Abdollahi E, Momtazi AA, Johnston TP, Sahebkar A (2018) Therapeutic effects of curcumin in inflammatory and immunemediated diseases: a nature-made jack-of-all-trades? J Cell Physiol 233(2):830\u2013848","DOI":"10.1002\/jcp.25778"},{"issue":"4","key":"2_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.15171\/jhp.2018.33","volume":"7","author":"N Boroumand","year":"2018","unstructured":"Boroumand N, Samarghandian S, Hashemy SI (2018) Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J Herb Med Pharmacol 7(4):211\u2013219","journal-title":"J Herb Med Pharmacol"},{"key":"2_CR7","doi-asserted-by":"crossref","unstructured":"Panahi Y, Ahmadi Y, Teymouri M, Johnston TP, Sahebkar A (2017)\u00a0Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms. J Cell Physiol 233(1):141\u2013152. https:\/\/doi.org\/10.1002\/jcp.25756. Epub 2017 Jun 6. PMID: 28012169","DOI":"10.1002\/jcp.25756"},{"issue":"1","key":"2_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2741\/e755","volume":"8","author":"RK Naz","year":"2016","unstructured":"Naz RK, Lough ML, Barthelmess EK (2016) Curcumin: a novel non-steroidal contraceptive with antimicrobial properties. Front Biosci (Elite Ed) 8(1):113\u2013128","journal-title":"Front Biosci (Elite Ed)"},{"key":"2_CR9","doi-asserted-by":"crossref","unstructured":"Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. BioFactors 43(3):331\u2013346.","DOI":"10.1002\/biof.1344"},{"key":"2_CR10","doi-asserted-by":"crossref","unstructured":"Mohajeri M, Bianconi V, \u00c1vila-Rodriguez MF, Barreto GE, Jamialahmadi T, Pirro M, Sahebkar A (2020)\u00a0Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res 156:104765. https:\/\/doi.org\/10.1016\/j.phrs.2020.104765. Epub 2020 Mar 23. PMID: 32217147","DOI":"10.1016\/j.phrs.2020.104765"},{"issue":"4","key":"2_CR11","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1080\/01635581.2018.1464347","volume":"70","author":"K Doello","year":"2018","unstructured":"Doello K, Ortiz R, Alvarez PJ, Melguizo C, Cabeza L, Prados J (2018) Latest in vitro and in vivo assay, clinical trials and patents in cancer treatment using curcumin: a literature review. Nutr Cancer 70(4):569\u2013578","journal-title":"Nutr Cancer"},{"key":"2_CR12","doi-asserted-by":"crossref","unstructured":"Iranshahi M, Sahebkar A, Hosseini ST, Takasaki M, Konoshima T, Tokuda H (2010) Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine 17(3-4):269\u2013273. https:\/\/doi:10.1016\/j.phymed.2009.05.020. Epub 2009 Jul3. PMID: 19577457","DOI":"10.1016\/j.phymed.2009.05.020"},{"issue":"1","key":"2_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2174\/1874471011666180831101459","volume":"12","author":"S Kolivand","year":"2019","unstructured":"Kolivand S, Amini P, Saffar H, Rezapoor S, Motevaseli E, Najafi M et al (2019) Evaluating the radioprotective effect of curcumin on rat\u2019s heart tissues. Curr Radiopharm 12(1):23\u201328","journal-title":"Curr Radiopharm"},{"issue":"4","key":"2_CR14","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/iub.2209","volume":"72","author":"F Forouzanfar","year":"2020","unstructured":"Forouzanfar F, Read MI, Barreto GE, Sahebkar A (2020) Neuroprotective effects of curcumin through autophagy modulation. IUBMB Life 72(4):652\u2013664","journal-title":"IUBMB Life"},{"key":"2_CR15","doi-asserted-by":"crossref","unstructured":"Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mend\u00eda LE, Sahebkar A (2017)\u00a0Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Drug Res (Stuttg) 67(4):244\u2013251. https:\/\/doi.org\/10.1055\/s-0043-100019. Epub 2017 Feb 3. PMID: 28158893.","DOI":"10.1055\/s-0043-100019"},{"issue":"4","key":"2_CR16","doi-asserted-by":"publisher","first-page":"151534","DOI":"10.1016\/j.acthis.2020.151534","volume":"122","author":"M Abd El-Kader","year":"2020","unstructured":"Abd El-Kader M, Taha RI (2020) Comparative nephroprotective effects of curcumin and etoricoxib against cisplatin-induced acute kidney injury in rats. Acta Histochem 122(4):151534. https:\/\/doi.org\/10.1016\/j.acthis.2020.151534","journal-title":"Acta Histochem"},{"key":"2_CR17","doi-asserted-by":"publisher","first-page":"172471","DOI":"10.1016\/j.ejphar.2019.172471","volume":"858","author":"N Aslanabadi","year":"2019","unstructured":"Aslanabadi N, Entezari-Maleki T, Rezaee H, Jafarzadeh HR, Vahedpour R (2019) Curcumin for the prevention of myocardial injury following elective percutaneous coronary intervention; a pilot randomized clinical trial. Eur J Pharmacol 858:172471. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172471","journal-title":"Eur J Pharmacol"},{"key":"2_CR18","doi-asserted-by":"crossref","unstructured":"Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B, Jamialahmadi T, Asgary S, Sahebkar A (2020)\u00a0Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Complementary Therapies in Medicine 49, 102322. https:\/\/doi.org\/10.1016\/j.ctim.2020.102322\u00a0","DOI":"10.1016\/j.ctim.2020.102322"},{"key":"2_CR19","doi-asserted-by":"publisher","unstructured":"Alvarenga L, Salarolli R, Cardozo LFMF, Santos RS, de Brito JS, Kemp JA, Reis D, de Paiva BR, Stenvinkel P, Lindholm B, Fouque D, Mafra D (2020) Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: a pilot randomized, double-blind, controlled study. Clin Nutr. S0261-5614(20)30110-2. https:\/\/doi.org\/10.1016\/j.clnu.2020.03.007","DOI":"10.1016\/j.clnu.2020.03.007"},{"issue":"3","key":"2_CR20","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/jcp.27192","volume":"234","author":"A Soltani","year":"2019","unstructured":"Soltani A, Salmaninejad A, Jalili-Nik M, Soleimani A, Javid H, Hashemy SI et al (2019) 5\u2032-adenosine monophosphate-activated protein kinase: a potential target for disease prevention by curcumin. J Cell Physiol 234(3):2241\u20132251","journal-title":"J Cell Physiol"},{"issue":"2","key":"2_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/10408398.2017.1366892","volume":"59","author":"M Saberi-Karimian","year":"2019","unstructured":"Saberi-Karimian M, Katsiki N, Caraglia M, Boccellino M, Majeed M, Sahebkar A (2019) Vascular endothelial growth factor: an important molecular target of curcumin. Crit Rev Food Sci Nutr 59(2):299\u2013312","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2_CR22","doi-asserted-by":"crossref","unstructured":"Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther 20(4):335\u2013345","DOI":"10.1007\/s40291-016-0202-7"},{"key":"2_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1201\/b10787-14","volume-title":"Herbal medicine: biomolecular and herbal medicine: biomolecular and clinical aspects","author":"S Prasad","year":"2011","unstructured":"Prasad S, Aggarwal BB (2011) Turmeric, the golden spice: from traditional medicine to modern medicine. In: Benzie IFF, Wachtel-Galor S (eds) Herbal medicine: biomolecular and herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press\/Taylor & Francis, Boca Raton, FL, pp 263\u2013288","edition":"2"},{"key":"2_CR24","volume-title":"Al-\u1e24\u0101wi fi\u2019l-\u1e6cibb (comprehensive book of medicine, in Arabic)","author":"MZ R\u0101zi","year":"1968","unstructured":"R\u0101zi MZ (1968) In: Kh\u0101n A (ed) Al-\u1e24\u0101wi fi\u2019l-\u1e6cibb (comprehensive book of medicine, in Arabic), vol 31. Osmania Oriental Publications Bureau, Osmania University, Hyderabad"},{"key":"2_CR25","volume-title":"Al-Q\u0101nun fi\u2019l-\u1e6cibb (canon of medicine, in Arabic)","author":"A Ibn Sin\u0101","year":"1987","unstructured":"Ibn Sin\u0101 A (1987) Al-Q\u0101nun fi\u2019l-\u1e6cibb (canon of medicine, in Arabic), vol 2. I.H.M.M.R. Printing Press, New Delhi"},{"key":"2_CR26","volume-title":"Al-Abniyah an \u1e24aq\u0101yeq al-Adwiyah (basics of realities on drugs, in Persian)","author":"M Herawi","year":"1967","unstructured":"Herawi M (1967) In: Bahm\u0101nyar A (ed) Al-Abniyah an \u1e24aq\u0101yeq al-Adwiyah (basics of realities on drugs, in Persian). Tehran University Publications, Tehran, Iran"},{"key":"2_CR27","volume-title":"Minh\u0101j al-Bay\u0101n f\u012bm\u0101 Yasta\u02bfmiluh\u016b al-Ins\u0101n (in Arabic)","author":"Y Ibn Jazlah","year":"1631","unstructured":"Ibn Jazlah Y (1631) Minh\u0101j al-Bay\u0101n f\u012bm\u0101 Yasta\u02bfmiluh\u016b al-Ins\u0101n (in Arabic). League of Arab States, Bulaq, Cairo, Egypt"},{"key":"2_CR28","volume-title":"Al-Jame\u02bfe le-Mofrad\u0101t al-Adwiah wal-Aghdhiyah (comprehensive book in simple drugs and foods in Arabic)","author":"Z Ibn Bey\u1e6d\u0101r","year":"2001","unstructured":"Ibn Bey\u1e6d\u0101r Z (2001) Al-Jame\u02bfe le-Mofrad\u0101t al-Adwiah wal-Aghdhiyah (comprehensive book in simple drugs and foods in Arabic), vol 2. D\u0101r al-K\u016bt\u016bb al-\u02bfElmiyah, Beirut, Lebanon"},{"key":"2_CR29","volume-title":"Tadhkereh Oul\u016bl-alb\u0101b (memorandum book, in Arabic)","author":"D An\u1e6d\u0101ki","year":"2000","unstructured":"An\u1e6d\u0101ki D (2000) In: Shams a\u2019ddin A (ed) Tadhkereh Oul\u016bl-alb\u0101b (memorandum book, in Arabic). D\u0101r-al-K\u016bt\u016bb al-\u02bfElmiyah, Beirut, Lebanon"},{"key":"2_CR30","volume-title":"To\u1e25fat al-Momenin (rarity of the faithful, in Persian)","author":"MM Tonek\u0101boni","year":"1959","unstructured":"Tonek\u0101boni MM (1959) To\u1e25fat al-Momenin (rarity of the faithful, in Persian). Mostafavi Press, Tehran, Iran"},{"key":"2_CR31","volume-title":"\u1e24adiqat al-Azh\u0101r fi M\u0101hiyyat al-\u02bfUshb wa al-\u02bfUqq\u0101r (Flower Garden in the Nature of Herbs and Drugs,in Arabic)","author":"AM Ghas\u0101ni","year":"1985","unstructured":"Ghas\u0101ni AM (1985) \u1e24adiqat al-Azh\u0101r fi M\u0101hiyyat al-\u02bfUshb wa al-\u02bfUqq\u0101r (Flower Garden in the Nature of Herbs and Drugs,in Arabic). D\u0101r al-Gharb al-Isl\u0101mi, Beirut, Lebanon"},{"key":"2_CR32","volume-title":"Makhzan al-Adwiah (Drug Treasure, in Persian). Reprinted from a copy which was printed in Calcutta dated in 1844","author":"MH Aqili Khor\u0101s\u0101ni","year":"1992","unstructured":"Aqili Khor\u0101s\u0101ni MH (1992) Makhzan al-Adwiah (Drug Treasure, in Persian). Reprinted from a copy which was printed in Calcutta dated in 1844. Enqelab-e Eslami Publishing and Educational Organization, Tehran, Iran"},{"key":"2_CR33","volume-title":"Dhakhireh Kh\u0101razmsh\u0101hi, (treasure of Kh\u0101razmsh\u0101h, in Persian), photoprint of the manuscript dated 1206 AD","author":"SI Jorj\u0101ni","year":"1977","unstructured":"Jorj\u0101ni SI (1977) In: Saeedi Sirjani AA (ed) Dhakhireh Kh\u0101razmsh\u0101hi, (treasure of Kh\u0101razmsh\u0101h, in Persian), photoprint of the manuscript dated 1206 AD. The lranian Culture Foundation, Tehran, Iran"},{"key":"2_CR34","volume-title":"Ba\u1e25r al-Jaw\u0101her (Sea of Gems, in Arabic)","author":"MY Herawi","year":"2008","unstructured":"Herawi MY (2008) Ba\u1e25r al-Jaw\u0101her (Sea of Gems, in Arabic). Institute of Revival of Natural Medicine, Qom"},{"key":"2_CR35","unstructured":"Qorashi AA (607-687 AH\/1211-1288 AD) al-Sh\u0101mel (The comprehensive, in Arabic). Vol. 19. Al Majma\u02bf al-Thaq\u0101fi. Abu-Dhabi, United Arab Emirates"},{"key":"2_CR36","volume-title":"Al-Aghr\u0101\u1e0d al-\u1e6cibbia wal Mab\u0101heth al-\u02bfAl\u0101iia (Medical Purposes and al-Al\u0203ee Investigations,in Persian)","author":"SI Jorj\u0101ni","year":"2006","unstructured":"Jorj\u0101ni SI (2006) Al-Aghr\u0101\u1e0d al-\u1e6cibbia wal Mab\u0101heth al-\u02bfAl\u0101iia (Medical Purposes and al-Al\u0203ee Investigations,in Persian), vol 1. Tehran University Publication, Tehran, Iran"},{"issue":"8","key":"2_CR37","doi-asserted-by":"publisher","first-page":"871","DOI":"10.2174\/1381612825666190402163940","volume":"25","author":"Z Ayati","year":"2019","unstructured":"Ayati Z, Ramezani M, Amiri MS, Moghadam AT, Rahimi H, Abdollahzade A et al (2019) Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review. Curr Pharm Des 25(8):871\u2013935","journal-title":"Curr Pharm Des"},{"issue":"4","key":"2_CR38","doi-asserted-by":"publisher","first-page":"274","DOI":"10.2174\/157340310793566172","volume":"6","author":"HR Vasanthi","year":"2010","unstructured":"Vasanthi HR, Parameswari RP (2010) Indian spices for healthy heart - an overview. Curr Cardiol Rev 6(4):274\u2013279","journal-title":"Curr Cardiol Rev"},{"issue":"3","key":"2_CR39","first-page":"10","volume":"6","author":"S Duggi","year":"2013","unstructured":"Duggi S, Harish H, Handral R, Tulsianand G, Shruthi SD (2013) Turmeric: nature\u2019s precious medicine. Asian J Pharm Clin Res 6(3):10\u201316","journal-title":"Asian J Pharm Clin Res"},{"key":"2_CR40","first-page":"293","volume-title":"Ethnobotany of India. Volume 3: North-East India and the Andaman and Nicobar Islands","author":"S Samala","year":"2017","unstructured":"Samala S, Veeresham C (2017) Ethnobotany of turmeric and its medicinal importance. In: Ethnobotany of India. Volume 3: North-East India and the Andaman and Nicobar Islands. CRC Press\/Taylor & Francis, Boca Raton, FL, pp 293\u2013316"},{"key":"2_CR41","first-page":"900","volume-title":"Principles and practice of phytotherapy: modern herbal medicine. Principles and practice of phytotherapy","author":"K Bone","year":"2012","unstructured":"Bone K, Mills S (2012) Principles and practice of phytotherapy: modern herbal medicine. Principles and practice of phytotherapy, 2nd edn. Elsevier, Austin, TX, pp 900\u2013918","edition":"2"},{"key":"2_CR42","unstructured":"Khanna NM (1999) Turmeric\u00a0\u2013 Nature\u2019s precious gift. Curr Sci 76(10):1351\u20131356"},{"issue":"2","key":"2_CR43","first-page":"243","volume":"45","author":"K Kawasaki","year":"2017","unstructured":"Kawasaki K, Fukuhara I, Muroyama K, Murosaki S (2017) Effect of a combination of hot water extract of Curcuma longa and curcumin on serum liver enzymes, inflammatory markers, and emotional states in healthy participants with moderately high body mass index: a randomized, double-blind, placebo-controlled clinical trial. Jpn Pharmacol Ther 45(2):243\u2013252","journal-title":"Jpn Pharmacol Ther"},{"issue":"1","key":"2_CR44","first-page":"52","volume":"14","author":"G Vafadar Afshar","year":"2020","unstructured":"Vafadar Afshar G, Rasmi Y, Yagmayee P, Khadem-Ansari MH, Makhdomii K, Rasooli J (2020) The effects of nano-curcumin supplementation on serum level of hs-CRP, adhesion molecules, and lipid profiles in hemodialysis patients, a randomized controlled clinical trial. Iran J Kidney Dis 14(1):52\u201361","journal-title":"Iran J Kidney Dis"},{"issue":"10","key":"2_CR45","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/1756-185X.13688","volume":"22","author":"M Javadi","year":"2019","unstructured":"Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri-Asl M (2019) Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: a randomized, double-blind, controlled trial. Int J Rheum Dis 22(10):1857\u20131862","journal-title":"Int J Rheum Dis"},{"issue":"6","key":"2_CR46","doi-asserted-by":"publisher","first-page":"874","DOI":"10.2174\/1871530319666190212170140","volume":"19","author":"M Abdolahi","year":"2019","unstructured":"Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, Tafakhori A et al (2019) The neuromodulatory effects of \u03c9-3 fatty acids and nano-curcumin on the COX-2\/iNOS network in migraines: a clinical trial study from gene expression to clinical symptoms. Endocr Metab Immune Disord Drug Targets 19(6):874\u2013884","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"6","key":"2_CR47","doi-asserted-by":"publisher","first-page":"430","DOI":"10.2174\/1871527317666180625101643","volume":"17","author":"M Abdolahi","year":"2018","unstructured":"Abdolahi M, Sarraf P, Javanbakht MH, Honarvar NM, Hatami M, Soveyd N et al (2018) A novel combination of \u03c9-3 fatty acids and nano-curcumin modulates interleukin-6 gene expression and high sensitivity C-reactive protein serum levels in patients with migraine: a randomized clinical trial study. CNS Neurol Disord Drug Targets 17(6):430\u2013438","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2_CR48","doi-asserted-by":"publisher","unstructured":"Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, Djalali M (2019) The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci:1\u201310. https:\/\/doi.org\/10.1080\/1028415X.2019.1627770","DOI":"10.1080\/1028415X.2019.1627770"},{"issue":"3","key":"2_CR49","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ctim.2015.04.001","volume":"23","author":"S Khayat","year":"2015","unstructured":"Khayat S, Fanaei H, Kheirkhah M, Moghadam ZB, Kasaeian A, Javadimehr M (2015) Curcumin attenuates severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial. Complement Ther Med 23(3):318\u2013324","journal-title":"Complement Ther Med"},{"issue":"5","key":"2_CR50","doi-asserted-by":"publisher","first-page":"330","DOI":"10.5001\/omj.2014.89","volume":"29","author":"R Afshariani","year":"2014","unstructured":"Afshariani R, Farhadi P, Ghaffarpasand F, Roozbeh J (2014) Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: a randomized, double-blind, placebo-controlled clinical trial. Oman Med J 29(5):330\u2013334","journal-title":"Oman Med J"},{"issue":"1","key":"2_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1667\/RR3255.1","volume":"180","author":"JL Ryan","year":"2013","unstructured":"Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP et al (2013) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res 180(1):34\u201343","journal-title":"Radiat Res"},{"key":"2_CR52","doi-asserted-by":"publisher","first-page":"102267","DOI":"10.1016\/j.ctim.2019.102267","volume":"48","author":"K Ataei-Almanghadim","year":"2020","unstructured":"Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M (2020) The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: a triple blind randomised controlled trial. Complement Ther Med 48:102267. https:\/\/doi.org\/10.1016\/j.ctim.2019.102267","journal-title":"Complement Ther Med"},{"issue":"11","key":"2_CR53","doi-asserted-by":"publisher","first-page":"9552","DOI":"10.1002\/jcb.27273","volume":"119","author":"M Masoodi","year":"2018","unstructured":"Masoodi M, Mahdiabadi MA, Mokhtare M, Agah S, Kashani AHF, Rezadoost AM et al (2018) The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients\u2019 self-reported well-being: a randomized double-blind controlled trial. J Cell Biochem 119(11):9552\u20139559","journal-title":"J Cell Biochem"},{"issue":"11","key":"2_CR54","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1055\/s-0034-1389986","volume":"65","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A (2014) Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: positive results of a randomized double-blind placebo-controlled trial. Drug Res 65(11):567\u2013573","journal-title":"Drug Res"},{"issue":"1","key":"2_CR55","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3109\/19390211.2014.952865","volume":"13","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A (2016) Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: a randomized controlled trial. J Diet Suppl 13(1):93\u2013105","journal-title":"J Diet Suppl"},{"issue":"5","key":"2_CR56","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/ptr.6323","volume":"33","author":"M Azhdari","year":"2019","unstructured":"Azhdari M, Karandish M, Mansoori A (2019) Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(5):1289\u20131301","journal-title":"Phytother Res"},{"issue":"11","key":"2_CR57","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/ptr.5174","volume":"28","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A (2014) Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res 28(11):1625\u20131631","journal-title":"Phytother Res"},{"issue":"Suppl 1","key":"2_CR58","first-page":"S51","volume":"95","author":"P Pinsornsak","year":"2012","unstructured":"Pinsornsak P, Niempoog S (2012) The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thail 95(Suppl 1):S51\u2013S58","journal-title":"J Med Assoc Thail"},{"issue":"7","key":"2_CR59","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1017\/S0007114511006544","volume":"108","author":"Y Panahi","year":"2012","unstructured":"Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL et al (2012) Improvement of Sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 108(7):1272\u20131279","journal-title":"Br J Nutr"},{"key":"2_CR60","doi-asserted-by":"publisher","first-page":"104280","DOI":"10.1016\/j.phrs.2019.104280","volume":"146","author":"CM White","year":"2019","unstructured":"White CM, Pasupuleti V, Roman YM, Li Y, Hernandez AV (2019) Oral turmeric\/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 146:104280. https:\/\/doi.org\/10.1016\/j.phrs.2019.104280","journal-title":"Pharmacol Res"},{"issue":"2","key":"2_CR61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.dsx.2020.01.002","volume":"14","author":"J Heshmati","year":"2020","unstructured":"Heshmati J, Golab F, Morvaridzadeh M, Potter E, Akbari-Fakhrabadi M, Farsi F et al (2020) The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor \u03b3 coactivator 1\u03b1 gene expression in polycystic ovarian syndrome (PCOS) patients: a randomized placebo-controlled clinical trial. Diabetes Metab Syndr 14(2):77\u201382","journal-title":"Diabetes Metab Syndr"},{"issue":"6","key":"2_CR62","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/MCO.0000000000000598","volume":"22","author":"BS Fleenor","year":"2019","unstructured":"Fleenor BS, Carlini NA, Campbell MS (2019) Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation. Curr Opin Clin Nutr Metab Care 22(6):459\u2013464","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.obmed.2018.11.002","volume":"13","author":"T Jin","year":"2019","unstructured":"Jin T (2019) Mechanisms underlying the metabolic beneficial effect of curcumin intervention: beyond anti-inflammation and anti-oxidative stress. Obes Med 13:1\u20135","journal-title":"Obes Med"},{"issue":"2","key":"2_CR64","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ptr.6226","volume":"33","author":"R Tabrizi","year":"2019","unstructured":"Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M et al (2019) The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(2):253\u2013262","journal-title":"Phytother Res"},{"key":"2_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2018.08.003","volume":"60","author":"S Qin","year":"2018","unstructured":"Qin S, Huang L, Gong J, Shen S, Huang J, Tang Y et al (2018) Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress. Nutr Res 60:1\u201312","journal-title":"Nutr Res"},{"key":"2_CR66","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3389\/fphar.2019.00649","volume":"10","author":"M Akbari","year":"2019","unstructured":"Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G et al (2019) The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 10:649. https:\/\/doi.org\/10.3389\/fphar.2019.00649","journal-title":"Front Pharmacol"},{"issue":"21","key":"2_CR67","first-page":"4195","volume":"19","author":"F Di Pierro","year":"2015","unstructured":"Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A (2015) Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Eur Rev Med Pharmacol Sci 19(21):4195\u20134202","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2_CR68","doi-asserted-by":"publisher","first-page":"102283","DOI":"10.1016\/j.ctim.2019.102283","volume":"48","author":"M Jalali","year":"2020","unstructured":"Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SP (2020) The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 48:102283. https:\/\/doi.org\/10.1016\/j.ctim.2019.102283","journal-title":"Complement Ther Med"},{"key":"2_CR69","doi-asserted-by":"crossref","unstructured":"Wei Z, Liu N, Tantai X, Xing X, Xiao C, Chen L et al (2019) The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatol Int 13(3):302\u2013313","DOI":"10.1007\/s12072-018-9910-x"},{"key":"2_CR70","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12986-019-0331-1","volume":"16","author":"SA Jazayeri-Tehrani","year":"2019","unstructured":"Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M et al (2019) Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond) 16:8. https:\/\/doi.org\/10.1186\/s12986-019-0331-1","journal-title":"Nutr Metab (Lond)"},{"key":"2_CR71","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.phrs.2017.09.010","volume":"128","author":"ISVD Melo","year":"2018","unstructured":"Melo ISVD, Santos AFD, Bueno NB (2018) Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 128:137\u2013144","journal-title":"Pharmacol Res"},{"issue":"9","key":"2_CR72","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/mnfr.201200131","volume":"57","author":"LX Na","year":"2013","unstructured":"Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M et al (2013) Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res 57(9):1569\u20131577","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"2_CR73","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/ptr.6542","volume":"34","author":"N Baziar","year":"2020","unstructured":"Baziar N, Parohan M (2020) The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: a systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res 34(3):464\u2013474","journal-title":"Phytother Res"},{"key":"2_CR74","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.nut.2019.01.002","volume":"62","author":"MS Campbell","year":"2019","unstructured":"Campbell MS, Ouyang A, Krishnakumar IM, Charnigo RJ, Westgate PM, Fleenor BS (2019) Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: a double-blinded, randomized, controlled trial. Nutrition 62:135\u2013139","journal-title":"Nutrition"},{"issue":"5","key":"2_CR75","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1590\/1516-3180.2018.0454120419","volume":"137","author":"A Ahmadi","year":"2019","unstructured":"Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M (2019) Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial. Sao Paulo Med J 137(5):414\u2013422","journal-title":"Sao Paulo Med J"},{"issue":"1","key":"2_CR76","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12937-017-0293-y","volume":"16","author":"S Qin","year":"2017","unstructured":"Qin S, Huang L, Gong J, Shen S, Huang J, Ren H et al (2017) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 16(1):68. https:\/\/doi.org\/10.1186\/s12937-017-0293-y","journal-title":"Nutr J"},{"issue":"27","key":"2_CR77","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.2174\/1381612824666180828162053","volume":"24","author":"R Tabrizi","year":"2018","unstructured":"Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M et al (2018) The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Curr Pharm Des 24(27):3184\u20133199","journal-title":"Curr Pharm Des"},{"issue":"4","key":"2_CR78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215840","volume":"14","author":"N Poolsup","year":"2019","unstructured":"Poolsup N, Suksomboon N, Kurnianta PDM, Deawjaroen K (2019) Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysis. PLoS One 14(4):e0215840. https:\/\/doi.org\/10.1371\/journal.pone.0215840","journal-title":"PLoS One"},{"issue":"5","key":"2_CR79","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1016\/j.dsx.2019.07.045","volume":"13","author":"CCT Clark","year":"2019","unstructured":"Clark CCT, Ghaedi E, Arab A, Pourmasoumi M, Hadi A (2019) The effect of curcumin supplementation on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr 13(5):2819\u20132825","journal-title":"Diabetes Metab Syndr"},{"issue":"3","key":"2_CR80","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/ptr.6270","volume":"33","author":"R Goodarzi","year":"2019","unstructured":"Goodarzi R, Sabzian K, Shishehbor F, Mansoori A (2019) Does turmeric\/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(3):561\u2013570","journal-title":"Phytother Res"},{"issue":"1","key":"2_CR81","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/10408398.2018.1517724","volume":"60","author":"SM Mousavi","year":"2020","unstructured":"Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A (2020) The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 60(1):171\u2013180","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2_CR82","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3389\/fncel.2018.00516","volume":"12","author":"C Fan","year":"2019","unstructured":"Fan C, Song Q, Wang P, Li Y, Yang M, Yu SY (2019) Neuroprotective effects of curcumin on IL-1\u03b2-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats. Front Cell Neurosci 12:516. https:\/\/doi.org\/10.3389\/fncel.2018.00516","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"2_CR83","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/ptr.6257","volume":"33","author":"LN Zhu","year":"2019","unstructured":"Zhu LN, Mei X, Zhang ZG, Xie YP, Lang F (2019) Curcumin intervention for cognitive function in different types of people: a systematic review and meta-analysis. Phytother Res 33(3):524\u2013533","journal-title":"Phytother Res"},{"issue":"6","key":"2_CR84","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jamda.2016.12.071","volume":"18","author":"QX Ng","year":"2017","unstructured":"Ng QX, Koh SSH, Chan HW, Ho CYX (2017) Clinical use of curcumin in depression: a meta-analysis. J Am Med Dir Assoc 18(6):503\u2013508","journal-title":"J Am Med Dir Assoc"},{"issue":"2","key":"2_CR85","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/ptr.5524","volume":"30","author":"D Al-Karawi","year":"2016","unstructured":"Al-Karawi D, Al Mamoori DA, Tayyar Y (2016) The role of curcumin administration in patients with major depressive disorder: mini meta-analysis of clinical trials. Phytother Res 30(2):175\u2013183","journal-title":"Phytother Res"},{"issue":"15","key":"2_CR86","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1080\/10408398.2019.1653260","volume":"60","author":"L Fusar-Poli","year":"2020","unstructured":"Fusar-Poli L, Vozza L, Gabbiadini A, Vanella A, Concas I, Tinacci S et al (2020) Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr 60(15):2643\u20132653","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2_CR87","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/B978-0-12-398456-2.00003-7","volume-title":"Polyphenols in human health and disease","author":"Z Tayarani-Najaran","year":"2014","unstructured":"Tayarani-Najaran Z, Tayarani N, Emami SA (2014) The history of islamic medicine at a glance. In: Watson RR, Preedy VR, Zibadi S (eds) Polyphenols in human health and disease. Academic Press, San Diego, CA, pp 17\u201327"},{"issue":"4","key":"2_CR88","doi-asserted-by":"publisher","first-page":"20180224","DOI":"10.1515\/jcim-2018-0224","volume":"16","author":"N Phoolcharoen","year":"2019","unstructured":"Phoolcharoen N, Oranratanaphan S, Ariyasriwatana C, Worasethsin P (2019) Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: a pilot randomized trial. J Complement Integr Med 16(4):20180224. https:\/\/doi.org\/10.1515\/jcim-2018-0224","journal-title":"J Complement Integr Med"},{"issue":"8","key":"2_CR89","first-page":"70","volume":"20","author":"L Zoodfekr","year":"2017","unstructured":"Zoodfekr L, Matinhomai H, Tarverdizadeh B (2017) The effect of aerobic exercise and curcumin consumption on clinical signs and serum levels of sexual hormones in 18-35 year-old women with premenstrual syndrome: a randomized clinical trial. Iran J Obstet Gynecol Infertil 20(8):70\u201379","journal-title":"Iran J Obstet Gynecol Infertil"},{"issue":"4","key":"2_CR90","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s12026-017-8917-z","volume":"65","author":"N Shao","year":"2017","unstructured":"Shao N, Jia H, Li Y, Li J (2017) Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-\u03b1: a randomized placebo-controlled double-blind clinical trial. Immunol Res 65(4):969\u2013974","journal-title":"Immunol Res"},{"key":"2_CR91","doi-asserted-by":"publisher","first-page":"898361","DOI":"10.1155\/2014\/898361","volume":"2014","author":"S Ganjali","year":"2014","unstructured":"Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S et al (2014) Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. ScientificWorldJournal 2014:898361. https:\/\/doi.org\/10.1155\/2014\/898361","journal-title":"ScientificWorldJournal"},{"issue":"10","key":"2_CR92","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/ptr.5149","volume":"28","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Saadat A, Beiraghdar F, Sahebkar A (2014) Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res 28(10):1461\u20131467","journal-title":"Phytother Res"},{"issue":"6","key":"2_CR93","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1258\/acb.2012.012040","volume":"49","author":"Y Panahi","year":"2012","unstructured":"Panahi Y, Sahebkar A, Parvin S, Saadat A (2012) A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Annal Clin Biochem 49(6):580\u2013588","journal-title":"Annal Clin Biochem"},{"issue":"8","key":"2_CR94","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1002\/ptr.6370","volume":"33","author":"S Saraf-Bank","year":"2019","unstructured":"Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M (2019) Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: a randomized placebo-controlled clinical trial. Phytother Res 33(8):2015\u20132022","journal-title":"Phytother Res"},{"issue":"3","key":"2_CR95","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/ptr.5998","volume":"32","author":"F Alizadeh","year":"2018","unstructured":"Alizadeh F, Javadi M, Karami AA, Gholaminejad F, Kavianpour M, Haghighian HK (2018) Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: a randomized clinical trial. Phytother Res 32(3):514\u2013521","journal-title":"Phytother Res"},{"issue":"3\u20134","key":"2_CR96","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000479634","volume":"71","author":"E Nasseri","year":"2017","unstructured":"Nasseri E, Mohammadi E, Tamaddoni A, Qujeq D, Zayeri F, Zand H (2017) Benefits of curcumin supplementation on antioxidant status in \u03b2-thalassemia major patients: a double-blind randomized controlled clinical trial. Ann Nutr Metab 71(3\u20134):136\u2013144","journal-title":"Ann Nutr Metab"},{"issue":"1","key":"2_CR97","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10787-016-0301-4","volume":"25","author":"Y Panahi","year":"2017","unstructured":"Panahi Y, Khalili N, Sahebi E, Namazi S, Karimian MS, Majeed M et al (2017) Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology 25(1):25\u201331","journal-title":"Inflammopharmacology"},{"issue":"2","key":"2_CR98","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/19390211.2015.1008611","volume":"13","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209\u2013220","journal-title":"J Diet Suppl"},{"issue":"1","key":"2_CR99","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.jff.2013.12.008","volume":"6","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Saadat A, Beiraghdar F, Hosseini Nouzari SM, Jalalian HR, Sahebkar A (2014) Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial. J Funct Foods 6(1):615\u2013622","journal-title":"J Funct Foods"},{"issue":"11","key":"2_CR100","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1089\/pho.2014.3805","volume":"32","author":"DPV Leite","year":"2014","unstructured":"Leite DPV, Paolillo FR, Parmesano TN, Fontana CR, Bagnato VS (2014) Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. Photomed Laser Surg 32(11):627\u2013632","journal-title":"Photomed Laser Surg"},{"issue":"7","key":"2_CR101","doi-asserted-by":"publisher","first-page":"842","DOI":"10.5005\/jp-journals-10024-2608","volume":"20","author":"KV Raghava","year":"2019","unstructured":"Raghava KV, Sistla KP, Narayan SJ, Yadalam U, Bose A, Mitra K (2019) Efficacy of curcumin as an adjunct to scaling and root planing in chronic periodontitis patients: a randomized controlled clinical trial. J Contemp Dent Pract 20(7):842\u2013846","journal-title":"J Contemp Dent Pract"},{"key":"2_CR102","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.clnesp.2020.01.005","volume":"36","author":"M Jamilian","year":"2020","unstructured":"Jamilian M, Foroozanfard F, Kavossian E, Aghadavod E, Shafabakhsh R, Hoseini A et al (2020) Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Nutr ESPEN 36:128\u2013133","journal-title":"Clin Nutr ESPEN"},{"key":"2_CR103","doi-asserted-by":"publisher","first-page":"102201","DOI":"10.1016\/j.ctim.2019.102201","volume":"47","author":"S Sohaei","year":"2019","unstructured":"Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H (2019) The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight\/obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. Complement Ther Med 47:102201. https:\/\/doi.org\/10.1016\/j.ctim.2019.102201","journal-title":"Complement Ther Med"},{"issue":"2","key":"2_CR104","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","volume":"25","author":"S Chuengsamarn","year":"2014","unstructured":"Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S (2014) Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem 25(2):144\u2013150","journal-title":"J Nutr Biochem"},{"issue":"6","key":"2_CR105","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1080\/19390211.2018.1472711","volume":"16","author":"H Safarian","year":"2019","unstructured":"Safarian H, Parizadeh SMR, Saberi-Karimain M, Darroudi S, Javandoost A, Mohammadi F et al (2019) The effect of curcumin on serum copper and zinc and Zn\/cu ratio in individuals with metabolic syndrome: a double-blind clinical trial. J Diet Suppl 16(6):625\u2013634","journal-title":"J Diet Suppl"},{"key":"2_CR106","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13098-019-0437-7","volume":"11","author":"H Hodaei","year":"2019","unstructured":"Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G (2019) The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr 11:41. https:\/\/doi.org\/10.1186\/s13098-019-0437-7","journal-title":"Diabetol Metab Syndr"},{"issue":"2","key":"2_CR107","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","volume":"59","author":"AFG Cicero","year":"2020","unstructured":"Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C (2020) Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 59(2):477\u2013483","journal-title":"Eur J Nutr"},{"key":"2_CR108","doi-asserted-by":"publisher","first-page":"100324","DOI":"10.1016\/j.hermed.2019.100324","volume":"21","author":"A Tamaddoni","year":"2019","unstructured":"Tamaddoni A, Nasseri E, Mohammadi E, Qujeq D, Zayeri F, Zand H et al (2019) A double-blind randomized controlled trial of curcumin for improvement in glycemic status, lipid profile and systemic inflammation in \u03b2-thalassemia major. J Herb Med 21:100324. https:\/\/doi.org\/10.1016\/j.hermed.2019.100324","journal-title":"J Herb Med"},{"issue":"1","key":"2_CR109","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s12906-019-2620-7","volume":"19","author":"MDC SilvaTAL","year":"2019","unstructured":"SilvaTAL MDC, Medeiros G, Medeiros R, de Souza AJ, Medeiros JA et al (2019) Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV\/AIDS: a randomized controlled trial. BMC Complement Altern Med 19(1):202. https:\/\/doi.org\/10.1186\/s12906-019-2620-7","journal-title":"BMC Complement Altern Med"},{"issue":"5","key":"2_CR110","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1002\/ptr.6328","volume":"33","author":"M Adibian","year":"2019","unstructured":"Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati M (2019) The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Phytother Res 33(5):1374\u20131383","journal-title":"Phytother Res"},{"key":"2_CR111","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.metabol.2017.12.009","volume":"82","author":"JJA Ferguson","year":"2018","unstructured":"Ferguson JJA, Stojanovski E, MacDonald-Wicks L, Garg ML (2018) Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism 82:22\u201335","journal-title":"Metabolism"},{"key":"2_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ctim.2017.05.006","volume":"33","author":"Y Panahi","year":"2017","unstructured":"Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner \u017d, Majeed M et al (2017) Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial. Complement Ther Med 33:1\u20135","journal-title":"Complement Ther Med"},{"issue":"10","key":"2_CR113","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.nut.2016.03.018","volume":"32","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Hosseini MS, Khalili N, Naimi E, Soflaei SS, Majeed M et al (2016) Effects of supplementation with curcumin on serum adipokine concentrations: a randomized controlled trial. Nutrition 32(10):1116\u20131122","journal-title":"Nutrition"},{"issue":"5","key":"2_CR114","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.ctim.2014.07.006","volume":"22","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A (2014) Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med 22(5):851\u2013857","journal-title":"Complement Ther Med"},{"issue":"12","key":"2_CR115","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1002\/ptr.5197","volume":"28","author":"YS Yang","year":"2014","unstructured":"Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC (2014) Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res 28(12):1770\u20131777","journal-title":"Phytother Res"},{"issue":"3","key":"2_CR116","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/ptr.4715","volume":"27","author":"A Mohammadi","year":"2013","unstructured":"Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M et al (2013) Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 27(3):374\u2013379","journal-title":"Phytother Res"},{"issue":"4","key":"2_CR117","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1055\/s-0043-100019","volume":"67","author":"Y Panahi","year":"2017","unstructured":"Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mend\u00eda LE, Sahebkar A (2017) Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res (Stuttg) 67(4):244\u2013251","journal-title":"Drug Res (Stuttg)"},{"issue":"9","key":"2_CR118","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/ptr.5659","volume":"30","author":"S Rahmani","year":"2016","unstructured":"Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A et al (2016) Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res 30(9):1540\u20131548","journal-title":"Phytother Res"},{"issue":"3","key":"2_CR119","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/FJC.0000000000000406","volume":"68","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mend\u00eda LE, Sahebkar A (2016) Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: a randomized controlled trial. J Cardiovasc Pharmacol 68(3):223\u2013229","journal-title":"J Cardiovasc Pharmacol"},{"issue":"7","key":"2_CR120","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1055\/s-0044-101752","volume":"68","author":"Y Panahi","year":"2018","unstructured":"Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mend\u00eda LE, Majeed M et al (2018) Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled trial. Drug Res (Stuttg) 68(7):403\u2013409","journal-title":"Drug Res (Stuttg)"},{"key":"2_CR121","doi-asserted-by":"publisher","first-page":"183","DOI":"10.15403\/jgld-179","volume":"28","author":"SR Mirhafez","year":"2019","unstructured":"Mirhafez SR, Farimani AR, Dehhabe M, Bidkhori M, Hariri M, Ghouchani BF et al (2019) Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial. J Gastrointestin Liver Dis 28:183\u2013189","journal-title":"J Gastrointestin Liver Dis"},{"issue":"9","key":"2_CR122","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1002\/ptr.6118","volume":"32","author":"E Mohammadi","year":"2018","unstructured":"Mohammadi E, Tamaddoni A, Qujeq D, Nasseri E, Zayeri F, Zand H et al (2018) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in \u03b2-thalassemia major patients: a double-blind randomized controlled clinical trial. Phytother Res 32(9):1828\u20131835","journal-title":"Phytother Res"},{"key":"2_CR123","doi-asserted-by":"publisher","first-page":"102351","DOI":"10.1016\/j.ctim.2020.102351","volume":"49","author":"M Nouri-Vaskeh","year":"2020","unstructured":"Nouri-Vaskeh M, Afshan H, Malek Mahdavi A, Alizadeh L, Fan X, Zarei M (2020) Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: a randomized, double-blind placebo-controlled trial. Complement Ther Med 49:102351. https:\/\/doi.org\/10.1016\/j.ctim.2020.102351","journal-title":"Complement Ther Med"},{"key":"2_CR124","doi-asserted-by":"publisher","first-page":"102322","DOI":"10.1016\/j.ctim.2020.102322","volume":"49","author":"M Sabery Karimian","year":"2020","unstructured":"Sabery Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B et al (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: an exploratory randomized controlled trial. Complement Ther Med 49:102322. https:\/\/doi.org\/10.1016\/j.ctim.2020.102322","journal-title":"Complement Ther Med"},{"issue":"6","key":"2_CR125","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1002\/ptr.6620","volume":"34","author":"M Nouri-Vaskeh","year":"2020","unstructured":"Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M (2020) Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Phytother Res 34(6):1446\u20131454","journal-title":"Phytother Res"},{"issue":"9","key":"2_CR126","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/s41430-018-0386-5","volume":"73","author":"S Chashmniam","year":"2019","unstructured":"Chashmniam S, Mirhafez SR, Dehabeh M, Hariri M, Azimi Nezhad M, Nobakht MGBF (2019) A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 73(9):1224\u20131235","journal-title":"Eur J Clin Nutr"},{"key":"2_CR127","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ctim.2019.02.014","volume":"43","author":"S Asadi","year":"2019","unstructured":"Asadi S, Gholami MS, Siassi F, Qorbani M, Khamoshian K, Sotoudeh G (2019) Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med 43:253\u2013260","journal-title":"Complement Ther Med"},{"issue":"4","key":"2_CR128","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/ptr.6571","volume":"34","author":"S Asadi","year":"2019","unstructured":"Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G (2019) Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res 34(4):896\u2013903","journal-title":"Phytother Res"},{"issue":"2","key":"2_CR129","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s13311-018-0606-7","volume":"15","author":"M Ahmadi","year":"2018","unstructured":"Ahmadi M, Agah E, Nafissi S, Jaafari MR, Harirchian MH, Sarraf P et al (2018) Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a pilot randomized clinical trial. Neurotherapeutics 15(2):430\u2013438","journal-title":"Neurotherapeutics"},{"issue":"3","key":"2_CR130","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jagp.2017.10.010","volume":"26","author":"GW Small","year":"2018","unstructured":"Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND et al (2018) Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatry 26(3):266\u2013277","journal-title":"Am J Geriatr Psychiatry"},{"issue":"10","key":"2_CR131","doi-asserted-by":"publisher","first-page":"767","DOI":"10.2174\/1871527317666180720162029","volume":"17","author":"L Chico","year":"2018","unstructured":"Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A et al (2018) Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation. CNS Neurol Disord Drug Targets 17(10):767\u2013779","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2_CR132","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.npep.2015.11.003","volume":"56","author":"H Fanaei","year":"2016","unstructured":"Fanaei H, Khayat S, Kasaeian A, Javadimehr M (2016) Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. Neuropeptides 56:25\u201331","journal-title":"Neuropeptides"},{"issue":"1","key":"2_CR133","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.euroneuro.2014.11.015","volume":"25","author":"AL Lopresti","year":"2015","unstructured":"Lopresti AL, Maes M, Meddens MJM, Maker GL, Arnoldussen E, Drummond PD (2015) Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. Eur Neuropsychopharmacol 25(1):38\u201350","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"2_CR134","first-page":"5536","volume":"9","author":"SA Esmaeili Vardanjani","year":"2012","unstructured":"Esmaeili Vardanjani SA, Sehati Shafai F, Mohebi P, Deyhimi M, Delazar A, Ghojazadeh M et al (2012) Wound healing benefits of curcumin for perineal repair after episiotomy: results of an Iranian randomized controlled trial. Life Sci J 9(4):5536\u20135541","journal-title":"Life Sci J"},{"issue":"41","key":"2_CR135","first-page":"40","volume":"11","author":"S Manifar","year":"2012","unstructured":"Manifar S, Obwaller A, Gharehgozloo A, Boorboor Shirazi Kordi HR, Akhondzadeh S (2012) Curcumin gel in the treatment of minor aphthous ulcer: a randomized, placebo- controlled trial. J Med Plants 11(41):40\u201345","journal-title":"J Med Plants"},{"issue":"1","key":"2_CR136","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/odi.12947","volume":"25","author":"P Piyush","year":"2019","unstructured":"Piyush P, Mahajan A, Singh K, Ghosh S, Gupta S (2019) Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: a randomized controlled trial. Oral Dis 25(1):73\u201379","journal-title":"Oral Dis"}],"container-title":["Advances in Experimental Medicine and Biology","Studies on Biomarkers and New Targets in Aging Research in Iran"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-56153-6_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T10:04:10Z","timestamp":1627725850000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-56153-6_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030561529","9783030561536"],"references-count":136,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-56153-6_2","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"1 August 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}