{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:31:52Z","timestamp":1783531912779,"version":"3.55.0"},"publisher-location":"Cham","reference-count":163,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030573614","type":"print"},{"value":"9783030573621","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-57362-1_10","type":"book-chapter","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T03:02:50Z","timestamp":1605582170000},"page":"209-243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["HTLV-1 Replication and Adult T Cell Leukemia Development"],"prefix":"10.1007","author":[{"given":"Chou-Zen","family":"Giam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"10_CR1","doi-asserted-by":"crossref","unstructured":"Anderson MD, Ye J, Xie L, Green PL (2004) Transformation studies with a human T-cell leukemia virus type 1 molecular clone. J Virol Methods 116(2):195\u2013202","DOI":"10.1016\/j.jviromet.2003.11.016"},{"key":"10_CR2","doi-asserted-by":"publisher","unstructured":"Andresen V, Pise-Masison CA, Sinha-Datta U, Bellon M, Valeri V, Washington Parks R et al (2011) Suppression of HTLV-1 replication by Tax-mediated rerouting of the P13 viral protein to nuclear speckles. Blood. 118(6):1549\u20131559. https:\/\/doi.org\/10.1182\/blood-2010-06-293340. Pubmed Pmid: 21677314; Pubmed Central Pmcid: Pmcpmc3156045","DOI":"10.1182\/blood-2010-06-293340"},{"key":"10_CR3","doi-asserted-by":"crossref","unstructured":"Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL (2008) Human T-cell leukemia virus type-1 antisense-encoded gene, HBZ, promotes T-lymphocyte proliferation. Blood 112(9):3788\u20133797","DOI":"10.1182\/blood-2008-04-154286"},{"issue":"18","key":"10_CR4","doi-asserted-by":"publisher","first-page":"9707","DOI":"10.1128\/JVI.00887-07","volume":"81","author":"P Banerjee","year":"2007","unstructured":"Banerjee P, Feuer G, Barker E (2007) Human T-cell leukemia virus type 1 (HTLV-1) P12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary Cd4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. J Virol 81(18):9707\u20139717","journal-title":"J Virol"},{"key":"10_CR5","doi-asserted-by":"publisher","unstructured":"Barbeau B, Peloponese JM, Mesnard JM (2013) Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis. Front Microbiol 4:226. https:\/\/doi.org\/10.3389\/fmicb.2013.00226 [Doi]","DOI":"10.3389\/fmicb.2013.00226"},{"key":"10_CR6","doi-asserted-by":"crossref","unstructured":"Barnard AL, Igakura T, Tanaka Y, Taylor GP, Bangham CR (2005) Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes. Blood 106(3):988\u2013995","DOI":"10.1182\/blood-2004-07-2850"},{"key":"10_CR7","doi-asserted-by":"crossref","unstructured":"Basbous J, Arpin C, Gaudray G, Piechaczyk M, Devaux C, Mesnard JM (2003) The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity. J Biol Chem 278(44):43620\u201343627","DOI":"10.1074\/jbc.M307275200"},{"key":"10_CR8","doi-asserted-by":"publisher","unstructured":"Baydoun HH, Bai XT, Shelton S, Nicot C (2012) HTLV-I Tax increases genetic instability by inducing dna double strand breaks during dna replication and switching repair to Nhej. Plos One 7(8):E42226. Epub 2012\/08\/24. https:\/\/doi.org\/10.1371\/journal.pone.0042226. Pubmed Pmid: 22916124; Pubmed Central Pmcid: Pmcpmc3423393","DOI":"10.1371\/journal.pone.0042226"},{"key":"10_CR9","doi-asserted-by":"crossref","unstructured":"Cereseto A, Diella F, Mulloy JC, Cara A, Michieli P, Grassmann R et al (1996) P53 functional impairment and high P21waf1\/CIP1 expression in human T-cell lymphotropic\/leukemia virus type I-transformed T cells. Blood 88(5):1551\u20131560","DOI":"10.1182\/blood.V88.5.1551.1551"},{"key":"10_CR10","doi-asserted-by":"publisher","unstructured":"Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC et al (2011) Initial genome sequencing and analysis of multiple myeloma. Nature 471(7339):467\u2013472. Doi:Nature09837 [Pii];https:\/\/doi.org\/10.1038\/nature09837 [Doi]","DOI":"10.1038\/nature09837"},{"key":"10_CR11","doi-asserted-by":"crossref","unstructured":"Charvet C, Canonigo Aj, Becart S, Maurer U, Miletic AV, Swat W (2006) VAV1 Promotes T cell cycle progression by linking TCR\/CD28 costimulation to FOXO1 and P27KIP1 expression. J Immunol 177(8):5024\u201350231. Pubmed Pmid: 17015685","DOI":"10.4049\/jimmunol.177.8.5024"},{"key":"10_CR12","doi-asserted-by":"publisher","unstructured":"Chen L, Flies DB (2013) Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 13(4):227\u2013242. https:\/\/doi.org\/10.1038\/nri3405. Pubmed Pmid: 23470321; Pubmed Central Pmcid: Pmcpmc3786574","DOI":"10.1038\/nri3405"},{"key":"10_CR13","unstructured":"Chlichlia K, Moldenhauer G, Daniel PT, Busslinger M, Gazzolo L, Schirrmacher V et al (1995) Immediate effects of reversible HTLV-1 Tax function: T-cell activation and apoptosis. Oncogene 10:269\u2013277"},{"key":"10_CR14","doi-asserted-by":"crossref","unstructured":"Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (1993) Phosphorylated creb binds specifically to the nuclear protein CBP. Nature 365:855\u2013859","DOI":"10.1038\/365855a0"},{"key":"10_CR15","doi-asserted-by":"crossref","unstructured":"Clerc I, Polakowski N, Ndre-Arpin C, Cook P, Barbeau B, Mesnard JM (2008) An interaction between the HTLV-1 bZip factor (Hbz) and the KIX domain of P300\/CBP contributes to the downregulation of Tax-dependent viral transcription by HBZ J Biol Chem 283:23903\u201323913","DOI":"10.1074\/jbc.M803116200"},{"key":"10_CR16","doi-asserted-by":"publisher","unstructured":"Cook LB, Rowan AG, Melamed A, Taylor GP, Bangham CR (2012) HTLV-1-infected T cells contain a single integrated provirus in natural infection. Blood 120(17):3488\u20133490. Doi:Blood-2012-07-445593 [Pii];https:\/\/doi.org\/10.1182\/blood-2012-07-445593 [Doi]","DOI":"10.1182\/blood-2012-07-445593"},{"key":"10_CR17","doi-asserted-by":"publisher","unstructured":"Cook LB, Melamed A, Niederer H, Valganon M, Laydon D, Foroni L et al (2014) The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia\/lymphoma. Blood 123(25):3925\u20133931. https:\/\/doi.org\/10.1182\/blood-2014-02-553602. Pubmed Pmid: 24735963; Pubmed Central Pmcid: Pmcpmc4064332","DOI":"10.1182\/blood-2014-02-553602"},{"key":"10_CR18","doi-asserted-by":"publisher","unstructured":"De Castro-Amarante MF, Pise-Masison CA, Mckinnon K, Washington Parks R, Galli V, Omsland M et al (2015) Human T cell leukemia virus type 1 infection of the three monocyte subsets contributes to viral burden in humans. J Virol 90(5):2195\u20132207. https:\/\/doi.org\/10.1128\/jvi.02735-15. Pubmed Pmid: 26608313; Pubmed Central Pmcid: Pmcpmc4810698","DOI":"10.1128\/jvi.02735-15"},{"key":"10_CR19","unstructured":"De La Fc, Santiago F, Chong Sy, Deng L, Mayhood T, Fu P et al (2000) Overexpression of P21(WAF1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A\/CDK2. J Virol 74(16):7270\u20137283"},{"key":"10_CR20","unstructured":"De La FC, Wang L, Wang D, Deng L, Wu K, Li H et al (2003) Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells. Molcell Biochem 245(1\u20132):99\u2013113"},{"key":"10_CR21","doi-asserted-by":"crossref","unstructured":"Derse D, Hill SA, Lloyd PA, Chung H, Morse BA (2001) Examining human T-lymphotropic virus type 1 infection and replication by cell-free infection with recombinant virus vectors 7. J Virol 75(18):8461\u20138468","DOI":"10.1128\/JVI.75.18.8461-8468.2001"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.2741\/1411","volume":"9","author":"D Derse","year":"2004","unstructured":"Derse D, Heidecker G, Mitchell M, Hill S, Lloyd P, Princler G (2004) Infectious transmission and replication of human T-cell leukemia virus type 1. Front Biosci 9:2495\u20132499","journal-title":"Front Biosci"},{"key":"10_CR23","doi-asserted-by":"publisher","unstructured":"Dodon MD, Villaudy J, Gazzolo L, Haines R, Lairmore M (2012) What we are learning on HTLV-1 pathogenesis from animal models. Front Microbiol. 3:320. https:\/\/doi.org\/10.3389\/fmicb.2012.00320. Pubmed Pmid: 22969759; Pubmed Central Pmcid: Pmcpmc3431546","DOI":"10.3389\/fmicb.2012.00320"},{"key":"10_CR24","doi-asserted-by":"publisher","unstructured":"Edwards D, Fenizia C, Gold H, De Castro-Amarante MF, Buchmann C, Pise-Masison CA et al (2011) ORF-I and ORF-II-encoded proteins in HTLV-1 infection and persistence. Viruses 3(6):861\u2013885. https:\/\/doi.org\/10.3390\/v3060861. Pubmed Pmid: 21994758; Pubmed Central Pmcid: Pmcpmc3185781","DOI":"10.3390\/v3060861"},{"key":"10_CR25","doi-asserted-by":"publisher","unstructured":"Einsiedel LJ, Pham H, Woodman RJ, Pepperill C, Taylor KA (2016) The prevalence and clinical associations of HTLV-1 infection in a remote indigenous community. Med J Aust 205(7):305\u2013309. Epub 2016\/09\/30. https:\/\/doi.org\/10.5694\/mja16.00285. Pubmed Pmid: 27681971","DOI":"10.5694\/mja16.00285"},{"key":"10_CR26","unstructured":"El Sabban ME, Nasr R, Dbaibo G, Hermine O, Abboushi N, Quignon F et al (2000) Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-KappaB activation. Blood 96(8):2849\u20132855"},{"key":"10_CR27","doi-asserted-by":"publisher","unstructured":"Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D et al (2013) Activation of the canonical IKK complex by K63\/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A 110(38):15247\u201315252. https:\/\/doi.org\/10.1073\/pnas.1314715110. Pubmed Pmid: 23986494; Pubmed Central Pmcid: Pmc3780889","DOI":"10.1073\/pnas.1314715110"},{"key":"10_CR28","doi-asserted-by":"publisher","unstructured":"Emmerich CH, Bakshi S, Kelsall IR, Ortiz-Guerrero J, Shpiro N, Cohen P (2016) Lys63\/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 474(3):452\u2013461. https:\/\/doi.org\/10.1016\/j.bbrc.2016.04.141. Pubmed Pmid: 27133719; Pubmed Central Pmcid: Pmcpmc4880150","DOI":"10.1016\/j.bbrc.2016.04.141"},{"key":"10_CR29","doi-asserted-by":"publisher","unstructured":"Fujikawa D, Nakagawa S, Hori M, Kurokawa N, Soejima A, Nakano K et al (2016) Polycomb-dependent epigenetic landscape in adult T-cell leukemia. Blood 127(14):1790\u20131802. Epub 2016\/01\/17. https:\/\/doi.org\/10.1182\/blood-2015-08-662593. Pubmed Pmid: 26773042","DOI":"10.1182\/blood-2015-08-662593"},{"key":"10_CR30","doi-asserted-by":"publisher","unstructured":"Galli V, Nixon CC, Strbo N, Artesi M, De Castro-Amarante MF, Mckinnon K et al (2019) Essential role of human T cell leukemia virus type 1 ORF-I in lethal proliferation of Cd4(+) cells in humanized mice. J Virol 93(19). Epub 2019\/07\/19. https:\/\/doi.org\/10.1128\/jvi.00565-19. Pubmed Pmid: 31315992; Pubmed Central Pmcid: Pmcpmc6744231","DOI":"10.1128\/jvi.00565-19"},{"key":"10_CR31","doi-asserted-by":"publisher","unstructured":"Gazon H, Lemasson I, Polakowski N, Cesaire R, Matsuoka M, Barbeau B et al (2012) Human T-cell leukemia virus type 1 (HTLV-1) Bzip factor requires cellular transcription factor jund to upregulate HTLV-1 antisense transcription from the 3\u2032 long terminal repeat. J Virol 86(17):9070\u20139078. Doi:Jvi.00661-12 [Pii]; https:\/\/doi.org\/10.1128\/jvi.00661-12 [Doi]","DOI":"10.1128\/jvi.00661-12"},{"key":"10_CR32","doi-asserted-by":"publisher","unstructured":"Gazon H, Belrose G, Terol M, Meniane JC, Mesnard JM, Cesaire R et al (2016) Impaired expression of Dicer and some micrornas in HBZ expressing cells from acute adult T-cell leukemia patients. Oncotarget 7(21):30258\u201330275. Epub 2016\/02\/06. https:\/\/doi.org\/10.18632\/oncotarget.7162. Pubmed Pmid: 26849145; Pubmed Central Pmcid: Pmcpmc5058679","DOI":"10.18632\/oncotarget.7162"},{"key":"10_CR33","doi-asserted-by":"publisher","unstructured":"Gazon H, Barbeau B, Mesnard JM, Peloponese JM Jr (2017) Hijacking of the AP-1 signaling pathway during development of ATl. Front Microbiol 8:2686. Epub 2018\/01\/31. https:\/\/doi.org\/10.3389\/fmicb.2017.02686. Pubmed Pmid: 29379481; Pubmed Central Pmcid: Pmcpmc5775265","DOI":"10.3389\/fmicb.2017.02686"},{"key":"10_CR34","doi-asserted-by":"publisher","unstructured":"Gessain A, Cassar O (2012) Epidemiological aspects and world distribution of HTLV-1 infection. Front Microb 3:388. https:\/\/doi.org\/10.3389\/fmicb.2012.00388 [Doi]","DOI":"10.3389\/fmicb.2012.00388"},{"key":"10_CR35","doi-asserted-by":"publisher","unstructured":"Giam CZ, Semmes OJ (2016) HTLV-1 Infection and adult T-cell leukemia\/lymphoma\u2014a tale of two proteins: Tax and HBZ. Viruses 8(6). Epub 2016\/06\/21. https:\/\/doi.org\/10.3390\/v8060161. Pubmed Pmid: 27322308; Pubmed Central Pmcid: Pmcpmc4926181","DOI":"10.3390\/v8060161"},{"key":"10_CR36","doi-asserted-by":"crossref","unstructured":"Grassmann R, Dengler C, Muller Fleckenstein I, Fleckenstein B, Mcguire K, Dokhelar MC et al (1989) Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a herpesvirus saimiri vector. Proc Natl Acad Sci U S A86:3351\u20133355","DOI":"10.1073\/pnas.86.9.3351"},{"key":"10_CR37","doi-asserted-by":"publisher","unstructured":"Gross C, Thoma-Kress AK (2016) Molecular mechanisms of HTLV-1 cell-to-cell transmission. Viruses 8(3). https:\/\/doi.org\/10.3390\/v8030074. Pubmed Pmid: 27005656; Pubmed Central Pmcid: Pmcpmc4810264","DOI":"10.3390\/v8030074"},{"key":"10_CR38","doi-asserted-by":"crossref","unstructured":"Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L (1995) Development of leukemia in mice transgenic for the Tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A92:1057\u20131061","DOI":"10.1073\/pnas.92.4.1057"},{"key":"10_CR39","doi-asserted-by":"publisher","unstructured":"Gruber K (2018) Australia tackles HTLV-1. Lancet Infect Dis 18(10):1073\u20131074. Epub 2018\/10\/12. https:\/\/doi.org\/10.1016\/s1473-3099(18)30561-9. Pubmed Pmid: 30303105","DOI":"10.1016\/s1473-3099(18)30561-9"},{"key":"10_CR40","doi-asserted-by":"publisher","unstructured":"Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E et al (2009) Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell 36(5):831\u2013844. Epub 2009\/12\/17. Doi:S1097-2765(09)00778-3 [Pii] https:\/\/doi.org\/10.1016\/j.molcel.2009.10.013. Pubmed Pmid: 20005846","DOI":"10.1016\/j.molcel.2009.10.013"},{"key":"10_CR41","doi-asserted-by":"crossref","unstructured":"Hall AP, Irvine J, Blyth K, Cameron ER, Onions DE, Campbell ME (1998) Tumours derived from HTLV-I Tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. J Pathol 186(2):209\u2013214","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I"},{"key":"10_CR42","doi-asserted-by":"crossref","unstructured":"Haoudi A, Semmes OJ (2003) The HTLV-1 Tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in P53 null cells 6. Virology 305(2):229\u2013239","DOI":"10.1006\/viro.2002.1642"},{"key":"10_CR43","doi-asserted-by":"crossref","unstructured":"Haoudi A, Daniels RC, Wong E, Kupfer G, Semmes OJ (2003) Human T-cell leukemia virus-I Tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response. J Biol Chem 278(39):37736\u201337744","DOI":"10.1074\/jbc.M301649200"},{"key":"10_CR44","doi-asserted-by":"publisher","unstructured":"Harhaj EW, Giam CZ (2018) NF-kappaB signaling mechanisms in HTLV-1-induced adult T-cell leukemia\/lymphoma. Febs J 285(18):3324\u20133336. Epub 2018\/05\/04. https:\/\/doi.org\/10.1111\/febs.14492. Pubmed Pmid: 29722927","DOI":"10.1111\/febs.14492"},{"key":"10_CR07","doi-asserted-by":"crossref","unstructured":"Harrod R, Tang Y, Nicot C, Lu HS, Vassilev A, Nakatani Y et al (1998) An exposed kid-like domain in human t-cell lymphotropic virus type 1 tax is responsible for the recruitment of coactivators cbp\/p300. Mol Cell Biol 18(9):5052\u20135061","DOI":"10.1128\/MCB.18.9.5052"},{"key":"10_CR45","doi-asserted-by":"crossref","unstructured":"Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y et al (2006) Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12(4):466\u2013472","DOI":"10.1038\/nm1389"},{"key":"10_CR46","doi-asserted-by":"publisher","unstructured":"Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y et al (2006) Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12(4):466\u2013472. Epub 2006\/03\/22. https:\/\/doi.org\/10.1038\/nm1389. Pubmed Pmid: 16550188","DOI":"10.1038\/nm1389"},{"key":"10_CR47","doi-asserted-by":"publisher","unstructured":"Hayakawa M (2012) Role of K63-linked polyubiquitination in NF-kappaB signalling: which ligase catalyzes and what molecule is targeted? J Biochem 151(2):115\u2013118. Doi:Mvr139 [Pii]; https:\/\/doi.org\/10.1093\/jb\/mvr139 [Doi]","DOI":"10.1093\/jb\/mvr139"},{"key":"10_CR48","doi-asserted-by":"crossref","unstructured":"Hinrichs SH, Nerenberg M, Reynolds RK, Khoury G, Jay G (1987) A transgenic mouse model for human neurofibromatosis. Science 237:1340\u20131343","DOI":"10.1126\/science.2888191"},{"issue":"15","key":"10_CR49","doi-asserted-by":"publisher","first-page":"9449","DOI":"10.1128\/JVI.79.15.9449-9457.2005","volume":"79","author":"H Hiraragi","year":"2005","unstructured":"Hiraragi H, Michael B, Nair A, Silic-Benussi M, Ciminale V, Lairmore M (2005) Human T-lymphotropic virus type 1 mitochondrion-localizing protein P13II sensitizes jurkat T cells to RAS-mediated apoptosis. Jvirol. 79(15):9449\u20139457","journal-title":"Jvirol."},{"key":"10_CR50","doi-asserted-by":"publisher","unstructured":"Ho YK, Zhi H, Debiaso D, Philip S, Shih HM, Giam CZ (2012) HTLV-1 Tax-induced rapid senescence is driven by the transcriptional activity of NF-kappaB and depends on chronically activated ikkalpha and P65\/Rela. J Virol 86(17):9474\u20139483. Doi:Jvi.00158-12 [Pii];https:\/\/doi.org\/10.1128\/jvi.00158-12 [Doi]","DOI":"10.1128\/jvi.00158-12"},{"key":"10_CR51","doi-asserted-by":"publisher","unstructured":"Ho YK, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor MA et al (2015) HTLV-1 Tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for Tak1 and IKK activation. Plos Pathog 11(8):E1005102. https:\/\/doi.org\/10.1371\/journal.ppat.1005102. Pubmed Pmid: 26285145; Pubmed Central Pmcid: Pmc4540474","DOI":"10.1371\/journal.ppat.1005102"},{"key":"10_CR52","unstructured":"Huey DD, Bolon B, La Perle KMD, Kannian P, Jacobson S, Ratner L et al (2018) Role of wild-type and recombinant human T-cell leukemia viruses in lymphoproliferative disease in humanized NSG mice. Comp Med 68(1):4\u201314. Epub 2018\/02\/21. Pubmed Pmid: 29460716; Pubmed Central Pmcid: Pmcpmc5824134"},{"key":"10_CR53","doi-asserted-by":"crossref","unstructured":"Igakura T, Stinchcombe JC, Goon PK, Taylor GP, Weber JN, Griffiths GM et al (2003) Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science 299(5613):1713\u2013176","DOI":"10.1126\/science.1080115"},{"key":"10_CR54","doi-asserted-by":"publisher","unstructured":"Jain P, Manuel Sl, Khan ZK, Ahuja J, Quann K, Wigdahl B (2009) DC-sign mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J Virol 2009;83(21):10908\u2013109021. https:\/\/doi.org\/10.1128\/jvi.01054-09. Pubmed Pmid: 19692463; Pubmed Central Pmcid: Pmcpmc2772783","DOI":"10.1128\/jvi.01054-09"},{"key":"10_CR55","doi-asserted-by":"crossref","unstructured":"Jeong SJ, Radonovich M, Brady JN, Pise-Masison CA (2004) HTLV-I Tax induces a novel interaction between P65\/Rela and P53 that results in inhibition of P53 transcriptional activity. Blood 104(5):1490\u20131497","DOI":"10.1182\/blood-2003-12-4174"},{"key":"10_CR56","doi-asserted-by":"crossref","unstructured":"Jones KS, Petrow-Sadowski C, Bertolette DC, Huang Y, Ruscetti FW (2005) Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into Cd4+ T cells. J Virol 79(20):12692\u201312702","DOI":"10.1128\/JVI.79.20.12692-12702.2005"},{"key":"10_CR57","doi-asserted-by":"crossref","unstructured":"Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW (2008) Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of Cd4(+) T cells. Nat Med 14(4):429\u2013436","DOI":"10.1038\/nm1745"},{"key":"10_CR58","doi-asserted-by":"publisher","unstructured":"Joshi RP, Koretzky GA (2013) Diacylglycerol kinases: regulated controllers of T cell activation, function, and development. Int J Mol Sci 14(4):6649\u201373. https:\/\/doi.org\/10.3390\/Ijms14046649. Pubmed Pmid: 23531532; Pubmed Central Pmcid: Pmcpmc3645659","DOI":"10.3390\/Ijms14046649"},{"key":"10_CR59","doi-asserted-by":"publisher","unstructured":"Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J et al (2015) Integrated molecular analysis of adult T cell leukemia\/lymphoma. Nat Genet 47(11):1304\u20131315. https:\/\/doi.org\/10.1038\/Ng.3415. Pubmed Pmid: 26437031","DOI":"10.1038\/Ng.3415"},{"key":"10_CR60","doi-asserted-by":"publisher","unstructured":"Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T et al (2018) Prognostic relevance of integrated genetic profiling in adult T-cell leukemia\/lymphoma. Blood 131(2):215\u2013225. Epub 2017\/11\/01. https:\/\/doi.org\/10.1182\/blood-2017-01-761874. Pubmed Pmid: 29084771","DOI":"10.1182\/blood-2017-01-761874"},{"key":"10_CR61","doi-asserted-by":"publisher","unstructured":"Katsuya H, Ishitsuka K, Utsunomiya A, Hanada S, Eto T, Moriuchi Y et al (2015) Treatment and survival among 1594 patients with ATL. Blood 126(24):2570\u20132577. Epub 2015\/09\/13. https:\/\/doi.org\/10.1182\/blood-2015-03-632489. Pubmed Pmid: 26361794","DOI":"10.1182\/blood-2015-03-632489"},{"key":"10_CR62","doi-asserted-by":"publisher","unstructured":"Katsuya H, Islam S, Tan BJY, Ito J, Miyazato P, Matsuo M et al (2019) The nature of the HTLV-1 provirus in naturally infected individuals analyzed by the viral DNA-capture-SEQ approach. Cell Rep 29(3):724\u201335 E4. Epub 2019\/10\/17. https:\/\/doi.org\/10.1016\/j.celrep.2019.09.016. Pubmed Pmid: 31618639","DOI":"10.1016\/j.celrep.2019.09.016"},{"key":"10_CR63","doi-asserted-by":"publisher","unstructured":"Katzav S (2015) VAV1: a Dr. Jekyll and Mr. Hyde protein\u2013good for the hematopoietic system, bad for cancer. Oncotarget 6(30):28731\u201328742. https:\/\/doi.org\/10.18632\/oncotarget.5086. Pubmed Pmid: 26353933; Pubmed Central Pmcid: Pmcpmc4745688","DOI":"10.18632\/oncotarget.5086"},{"key":"10_CR64","doi-asserted-by":"publisher","unstructured":"Kawatsuki A, Yasunaga Ji, Mitobe Y, Green Pl, Matsuoka M (2016) HTLV-1 bZip factor protein targets the RB\/E2F-1 pathway to promote proliferation and apoptosis of primary CD4 T cells. Oncogene. https:\/\/doi.org\/10.1038\/onc.2015.510. Pubmed Pmid: 26804169","DOI":"10.1038\/onc.2015.510"},{"key":"10_CR65","first-page":"1463","volume":"7","author":"K Kelly","year":"1992","unstructured":"Kelly K, Davis P, Mitsuya H, Irving S, Wright J, Grassmann R et al (1992) A high proportion of early response genes are constitutively activated in T cells by HTLV-I. Oncogene 7:1463\u20131470","journal-title":"Oncogene"},{"key":"10_CR66","doi-asserted-by":"publisher","unstructured":"Kogure Y, Kataoka K (2017) Genetic alterations in adult T-Cell leukemia\/lymphoma. Cancer Sci 108(9):1719\u20131725. Epub 2017\/06\/20. https:\/\/doi.org\/10.1111\/cas.13303. Pubmed Pmid: 28627735; Pubmed Central Pmcid: Pmcpmc5581529","DOI":"10.1111\/cas.13303"},{"key":"10_CR67","doi-asserted-by":"crossref","unstructured":"Kuhlmann AS, Villaudy J, Gazzolo L, Castellazzi M, Mesnard JM, Duc DM (2007) HTLV-1 HBZ cooperates with jund to enhance transcription of the human telomerase reverse transcriptase gene (Htert). Retrovirology 4:92","DOI":"10.1186\/1742-4690-4-92"},{"key":"10_CR05","doi-asserted-by":"crossref","unstructured":"Kwok RP, Laurance ME, Lundblad JR, Goldman PS, Shih H, Connor LM et al (1996) Control of camp-regulated enhancers by the viral transactivator tax through creb and the co-activator cbp. Nature 380(6575):642\u2013646","DOI":"10.1038\/380642a0"},{"issue":"21","key":"10_CR68","doi-asserted-by":"publisher","first-page":"5176","DOI":"10.1182\/blood-2008-04-150342","volume":"113","author":"S Lambert","year":"2009","unstructured":"Lambert S, Bouttier M, Vassy R, Seigneuret M, Petrow-Sadowski C, Janvier S et al (2009) HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165. Blood 113(21):5176\u20135185","journal-title":"Blood"},{"key":"10_CR69","doi-asserted-by":"publisher","unstructured":"Landry S, Halin M, Vargas A, Lemasson I, Mesnard JM, Barbeau B (2009) Upregulation of human T-cell leukemia virus type 1 antisense transcription by the viral Tax protein. J Virol 83(4):2048\u20132054. Doi:Jvi.01264-08 [Pii]; https:\/\/doi.org\/10.1128\/jvi.01264-08 [Doi]","DOI":"10.1128\/jvi.01264-08"},{"key":"10_CR70","doi-asserted-by":"crossref","unstructured":"Lefebvre L, Vanderplasschen A, Ciminale V, Heremans H, Dangoisse O, Jauniaux JC et al (2002) Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 P13(II) accessory proteins interact with Farnesyl pyrophosphate synthetase. J Virol 76(3):1400\u20131414. Pubmed Pmid: 11773414; Pubmed Central Pmcid: Pmcpmc135811","DOI":"10.1128\/JVI.76.3.1400-1414.2002"},{"key":"10_CR71","doi-asserted-by":"crossref","unstructured":"Lemasson I, Lewis MR, Polakowski N, Hivin P, Cavanagh MH, Thebault S et al (2007) Human T-cell leukemia virus type 1 (HTLV-1) bZip Protein interacts with the cellular transcription factor creb to inhibit HTLV-1 transcription. J Virol 81(4):1543\u20131453","DOI":"10.1128\/JVI.00480-06"},{"key":"10_CR03","doi-asserted-by":"crossref","unstructured":"Lenzmeier BA, Giebler HA, Nyborg JK (1998) Human T-cell leukemia virus type I Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter. Mol Cell Biol 18:721\u2013731","DOI":"10.1128\/MCB.18.2.721"},{"key":"10_CR72","doi-asserted-by":"publisher","unstructured":"Li M, Kesic M, Yin H, Yu L, Green PL (2009) Kinetic analysis of human T-cell leukemia virus type 1 gene expression in cell culture and infected animals. J Virol 83(8):3788\u20133797. Jvi.02315-08 [Pii];https:\/\/doi.org\/10.1128\/jvi.02315-08 [Doi]","DOI":"10.1128\/jvi.02315-08"},{"issue":"17","key":"10_CR73","doi-asserted-by":"publisher","first-page":"8442","DOI":"10.1128\/JVI.00091-08","volume":"82","author":"M Liu","year":"2008","unstructured":"Liu M, Yang L, Zhang L, Liu B, Merling R, Xia Z et al (2008) Human T-Cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle. J Virol 82(17):8442\u20138455","journal-title":"J Virol"},{"key":"10_CR74","doi-asserted-by":"publisher","unstructured":"Ma G, Yasunaga J, Matsuoka M (2016) Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis. Retrovirology 13:16. Epub 2016\/03\/17. https:\/\/doi.org\/10.1186\/s12977-016-0249-x. Pubmed Pmid: 26979059; Pubmed Central Pmcid: Pmcpmc4793531","DOI":"10.1186\/s12977-016-0249-x"},{"key":"10_CR75","doi-asserted-by":"publisher","unstructured":"Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K et al (2018) Sporadic on\/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Proc Natl Acad Sci U S A 115(6):E1269\u2013E1278. Epub 2018\/01\/24. https:\/\/doi.org\/10.1073\/pnas.1715724115. Pubmed Pmid: 29358408; Pubmed Central Pmcid: Pmcpmc5819419","DOI":"10.1073\/pnas.1715724115"},{"key":"10_CR76","doi-asserted-by":"crossref","unstructured":"Majone F, Jeang KT (2000) Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks. J Biol Chem 275(42):32906\u201332910","DOI":"10.1074\/jbc.C000538200"},{"key":"10_CR77","doi-asserted-by":"crossref","unstructured":"Majone F, Semmes OJ, Jeang KT (1993) Induction of micronuclei by HTLV-I Tax: a cellular assay for function. Virology 193:456\u2013459","DOI":"10.1006\/viro.1993.1145"},{"key":"10_CR78","doi-asserted-by":"crossref","unstructured":"Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL (2003) The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115(4):449\u2013459","DOI":"10.1016\/S0092-8674(03)00881-X"},{"key":"10_CR79","doi-asserted-by":"publisher","unstructured":"Manivannan K, Rowan AG, Tanaka Y, Taylor GP, Bangham CR (2016) CADM1\/TSLC1 identifies HTLV-1-infected cells and determines their susceptibility to CTL-mediated lysis. PLoS Pathog 12(4):E1005560. Epub 2016\/04\/23. https:\/\/doi.org\/10.1371\/journal.ppat.1005560. Pubmed Pmid: 27105228; Pubmed Central Pmcid: Pmcpmc4841533","DOI":"10.1371\/journal.ppat.1005560"},{"issue":"39","key":"10_CR80","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.1038\/sj.onc.1208976","volume":"24","author":"SJ Marriott","year":"2005","unstructured":"Marriott SJ, Semmes OJ (2005) Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. Oncogene 24(39):5986\u20135995","journal-title":"Oncogene"},{"key":"10_CR81","doi-asserted-by":"crossref","unstructured":"Matsumoto K, Shibata H, Fujisawa JI, Inoue H, Hakura A, Tsukahara T et al (1997) Human T-cell leukemia virus type 1 Tax protein transforms RAT fibroblasts via two distinct pathways 12. J Virol 71(6):4445\u20134451","DOI":"10.1128\/JVI.71.6.4445-4451.1997"},{"key":"10_CR82","doi-asserted-by":"publisher","unstructured":"Matsuoka M, Green PL (2009) The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 6:71. https:\/\/doi.org\/10.1186\/1742-4690-6-71. Pubmed Pmid: 19650892; Pubmed Central Pmcid: Pmc2731725","DOI":"10.1186\/1742-4690-6-71"},{"issue":"4","key":"10_CR83","first-page":"270","volume":"7","author":"M Matsuoka","year":"2007","unstructured":"Matsuoka M, Jeang KT (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Natrevcancer 7(4):270\u2013280","journal-title":"Natrevcancer"},{"key":"10_CR84","doi-asserted-by":"publisher","unstructured":"Matsuoka M, Mesnard JM (2020) HTLV-1 bZip factor: the key viral gene for pathogenesis. Retrovirology 17(1):2. Epub 2020\/01\/10. https:\/\/doi.org\/10.1186\/s12977-020-0511-0. Pubmed Pmid: 31915026; Pubmed Central Pmcid: Pmcpmc6950816","DOI":"10.1186\/s12977-020-0511-0"},{"key":"10_CR85","doi-asserted-by":"publisher","unstructured":"Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D (2010) Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors. PLoS Pathog 6(2):E1000788. https:\/\/doi.org\/10.1371\/journal.ppat.1000788 [Doi]","DOI":"10.1371\/journal.ppat.1000788"},{"key":"10_CR86","doi-asserted-by":"publisher","unstructured":"Mesnard JM, Barbeau B, Devaux C (2006) HBZ, a new important player in the mystery of adult T-cell leukemia. Blood. 108(13):3979\u20133982. https:\/\/doi.org\/10.1182\/blood-2006-03-007732. Pubmed Pmid: 16917009","DOI":"10.1182\/blood-2006-03-007732"},{"issue":"6","key":"10_CR87","first-page":"978","volume":"72","author":"I Miyoshi","year":"1981","unstructured":"Miyoshi I, Kubonishi I, Yoshimoto S, Shiraishi Y (1981) A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells. GANN 72(6):978\u2013981","journal-title":"GANN"},{"key":"10_CR88","doi-asserted-by":"publisher","unstructured":"Nakagawa M, Shaffer AL 3rd, Ceribelli M, Zhang M, Wright G, Huang DW et al (2018) Targeting the HTLV-I-regulated BATF3\/IRF4 transcriptional network in adult T cell leukemia\/lymphoma. Cancer Cell 34(2):286\u2013297 E10. Epub 2018\/07\/31. https:\/\/doi.org\/10.1016\/j.ccell.2018.06.014. Pubmed Pmid: 30057145","DOI":"10.1016\/j.ccell.2018.06.014"},{"key":"10_CR89","doi-asserted-by":"publisher","unstructured":"Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H et al (2016) Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun 7:12547. https:\/\/doi.org\/10.1038\/Ncomms12547. Pubmed Pmid: 27552911; Pubmed Central Pmcid: Pmcpmc4999505","DOI":"10.1038\/Ncomms12547"},{"key":"10_CR90","doi-asserted-by":"crossref","unstructured":"Nejmeddine M, Barnard AL, Tanaka Y, Taylor GP, Bangham CR (2005) Human T-lymphotropic virus, type 1, Tax protein triggers microtubule reorientation in the virological synapse. J Biol Chem 280(33):29653\u201329660","DOI":"10.1074\/jbc.M502639200"},{"key":"10_CR91","doi-asserted-by":"publisher","unstructured":"Nejmeddine M, Negi VS, Mukherjee S, Tanaka Y, Orth K, Taylor GP et al (2009) HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse. Blood 114(5):1016\u20131025. https:\/\/doi.org\/10.1182\/blood-2008-03-136770. Pubmed Pmid: 19494354","DOI":"10.1182\/blood-2008-03-136770"},{"key":"10_CR92","doi-asserted-by":"crossref","unstructured":"Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G (1987) The TAT gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237:1324\u20131329","DOI":"10.1126\/science.2888190"},{"key":"10_CR93","doi-asserted-by":"crossref","unstructured":"Nicot C, Dundr M, Johnson JM, Fullen JR, Alonzo N, Fukumoto R et al (2004) HTLV-1-encoded P30II is a post-transcriptional negative regulator of viral replication. Nat Med 10(2):197\u2013201","DOI":"10.1038\/nm984"},{"key":"10_CR94","doi-asserted-by":"publisher","unstructured":"Niederer HA, Bangham CR (2014) Integration site and clonal expansion in human chronic retroviral infection and gene therapy. Viruses 6(11):4140\u20134164. https:\/\/doi.org\/10.3390\/V6114140. Pubmed Pmid: 25365582; Pubmed Central Pmcid: Pmcpmc4246213","DOI":"10.3390\/V6114140"},{"key":"10_CR95","unstructured":"Nyborg JK, Egan D, Sharma N (2009) The HTLV-1 Tax protein: revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly. Bio Chim Biophys Acta 1799(3\u20134):266\u2013274"},{"key":"10_CR96","doi-asserted-by":"publisher","unstructured":"Ohsugi T, Kumasaka T, Okada S, Urano T (2007) The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells. Nat Med 13(5):527\u2013528. Epub 2007\/05\/05. https:\/\/doi.org\/10.1038\/nm0507-527. Pubmed Pmid: 17479090","DOI":"10.1038\/nm0507-527"},{"issue":"4","key":"10_CR97","first-page":"621","volume":"110","author":"A Okayama","year":"2004","unstructured":"Okayama A, Stuver S, Matsuoka M, Ishizaki J, Tanaka G, Kubuki Y et al (2004) Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia\/lymphoma in asymptomatic carriers. Intjcancer. 110(4):621\u2013625","journal-title":"Intjcancer."},{"key":"10_CR98","doi-asserted-by":"crossref","unstructured":"Pais-Correia AM, Sachse M, Guadagnini S, Robbiati V, Lasserre R, Gessain A et al (2010) Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat Med 16(1):83\u201389","DOI":"10.1038\/nm.2065"},{"key":"10_CR99","doi-asserted-by":"publisher","unstructured":"Panfil AR, Al-Saleem JJ, Green PL (2013) Animal models utilized in HTLV-1 research. Virology (Auckl) 4:49\u201359. https:\/\/doi.org\/10.4137\/Vrt.S12140. Pubmed Pmid: 25512694; Pubmed Central Pmcid: Pmcpmc4222344","DOI":"10.4137\/Vrt.S12140"},{"key":"10_CR02","doi-asserted-by":"crossref","unstructured":"Paca Uccaralertkun S, Zhao LJ, Adya N, Cross JV, Cullen BR, Boros IM et al (1994) In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax. Mol Cell Biol 14:456\u2013462","DOI":"10.1128\/MCB.14.1.456"},{"key":"10_CR100","doi-asserted-by":"publisher","unstructured":"Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A (2011) Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Gen 43(9):830\u2013837. https:\/\/doi.org\/10.1038\/Ng.892. Pubmed Pmid: 21804550; Pubmed Central Pmcid: Pmcpmc3297422","DOI":"10.1038\/Ng.892"},{"key":"10_CR101","doi-asserted-by":"publisher","unstructured":"Philip S, Zahoor MA, Zhi H, Ho YK, Giam CZ (2014) Regulation of human t-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog 10(4):E1004040. https:\/\/doi.org\/10.1371\/journal.ppat.1004040. Pubmed Pmid: 24699669; Pubmed Central Pmcid: Pmc3974842","DOI":"10.1371\/journal.ppat.1004040"},{"key":"10_CR102","unstructured":"Pise-Masison CA, Mahieux R, Jiang H, Ashcroft M, Radonovich M, Duvall J et al (2000) Inactivation of P53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on P53 Phosphorylation. Molcell Biol. 20(10):3377\u20133386"},{"key":"10_CR103","doi-asserted-by":"publisher","unstructured":"Pise-Masison CA, De Castro-Amarante MF, Enose-Akahata Y, Buchmann RC, Fenizia C, Washington Parks R et al (2014) Co-dependence of HTLV-1 P12 and P8 functions in virus persistence. PLoS Pathog 10(11):E1004454. https:\/\/doi.org\/10.1371\/journal.ppat.1004454. Pubmed Pmid: 25375128; Pubmed Central Pmcid: Pmcpmc4223054","DOI":"10.1371\/journal.ppat.1004454"},{"key":"10_CR104","first-page":"413","volume":"10","author":"R Pozzatti","year":"1990","unstructured":"Pozzatti R, Vogel J, Jay G (1990) The human T-lymphotropic virus type I Tax gene can cooperate with the RAS Oncogene to induce neoplastic transformation of cells. Molcell Biol 10:413\u2013417","journal-title":"Molcell Biol"},{"key":"10_CR105","doi-asserted-by":"publisher","unstructured":"Rauch DA, Ratner L (2011) Targeting HTLV-1 activation of NF-kappaB in mouse models and Atll patients. Viruses 3(6):886\u2013900. https:\/\/doi.org\/10.3390\/v3060886. Pubmed Pmid: 21994759; Pubmed Central Pmcid: Pmc3185776","DOI":"10.3390\/v3060886"},{"key":"10_CR106","doi-asserted-by":"crossref","unstructured":"Rivera-Walsh I, Waterfield M, Xiao G, Fong A, Sun SC (2001) NF-KappaB signaling pathway governs trail gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J Biol Chem 276(44):40385\u201340388","DOI":"10.1074\/jbc.C100501200"},{"issue":"3","key":"10_CR107","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1182\/blood-2004-03-1222","volume":"105","author":"H Sasaki","year":"2005","unstructured":"Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T et al (2005) Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood 105(3):1204\u20131213","journal-title":"Blood"},{"issue":"3","key":"10_CR108","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1073\/pnas.0507631103","volume":"103","author":"Y Satou","year":"2006","unstructured":"Satou Y, Yasunaga J, Yoshida M, Matsuoka M (2006) HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Procnatlacadsciusa 103(3):720\u2013725","journal-title":"Procnatlacadsciusa"},{"issue":"11","key":"10_CR109","first-page":"1525","volume":"49","author":"Y Satou","year":"2008","unstructured":"Satou Y, Yasunaga J, Yoshida M, Matsuoka M (2008) HTLV-1 bZip factor (HBZ) gene has a growth-promoting effect on adult T-cell leukemia cells. Rinsho Ketsueki 49(11):1525\u20131529","journal-title":"Rinsho Ketsueki"},{"key":"10_CR110","doi-asserted-by":"publisher","unstructured":"Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K et al (2011) HTLV-1 bZip factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog 7(2):E1001274. https:\/\/doi.org\/10.1371\/journal.ppat.1001274 [Doi]","DOI":"10.1371\/journal.ppat.1001274"},{"key":"10_CR111","doi-asserted-by":"crossref","unstructured":"Semmes OJ, Majone F, Cantemir C, Turchetto L, Hjelle B, Jeang KT (1996) HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs. Virology 217(1):373\u2013379","DOI":"10.1006\/viro.1996.0126"},{"key":"10_CR112","doi-asserted-by":"crossref","unstructured":"Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G et al (2001) Activation by Ikkalpha of a second, evolutionary conserved, NF-KappaB signaling pathway. Science 293(5534):1495\u20131499","DOI":"10.1126\/science.1062677"},{"key":"10_CR113","doi-asserted-by":"crossref","unstructured":"Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW (2007) The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol 81(24):13735\u201313742","DOI":"10.1128\/JVI.01790-07"},{"key":"10_CR114","doi-asserted-by":"publisher","unstructured":"Shibata Y, Tanaka Y, Gohda J, Inoue J (2011) Activation of the IkappaB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination. J Bio Chem 150(6):679\u2013686. Doi:Mvr106 [Pii]; https:\/\/doi.org\/10.1093\/jb\/mvr106 [Doi]","DOI":"10.1093\/jb\/mvr106"},{"key":"10_CR115","doi-asserted-by":"publisher","unstructured":"Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y et al (2017) HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. Plos Pathog 13(1):E1006162. https:\/\/doi.org\/10.1371\/Journal.Ppat.1006162. Pubmed Pmid: 28103322; Pubmed Central Pmcid: Pmcpmc5283754","DOI":"10.1371\/Journal.Ppat.1006162"},{"key":"10_CR116","doi-asserted-by":"crossref","unstructured":"Shimoyama M (1991) Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the lymphoma study group (1984\u201387). Br J Haematol 79(3):428\u2013437","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"10_CR117","doi-asserted-by":"publisher","unstructured":"Shudofsky AMD, Giam CZ (2019) Cells of adult t-cell leukemia evade HTLV-1 Tax\/NF-KappaB hyperactivation-induced senescence. Blood Adv. 3(4):564\u2013569. Epub 2019\/02\/23. https:\/\/doi.org\/10.1182\/bloodadvances.2018029322. Pubmed Pmid: 30787019; Pubmed Central Pmcid: Pmcpmc6391679","DOI":"10.1182\/bloodadvances.2018029322"},{"issue":"17","key":"10_CR118","doi-asserted-by":"publisher","first-page":"6629","DOI":"10.1073\/pnas.0305502101","volume":"101","author":"M Silic-Benussi","year":"2004","unstructured":"Silic-Benussi M, Cavallari I, Zorzan T, Rossi E, Hiraragi H, Rosato A et al (2004) Suppression of tumor growth and cell proliferation by P13II, a mitochondrial protein of human T cell leukemia virus type 1. Proc Natl Acad Sci USA 101(17):6629\u20136634","journal-title":"Proc Natl Acad Sci USA"},{"key":"10_CR119","doi-asserted-by":"crossref","unstructured":"Sinha-Datta U, Horikawa I, Michishita E, Datta A, Sigler-Nicot JC, Brown M et al (2004) Transcriptional activation of htert through the NF-kappaB pathway in HTLV-I-transformed cells. Blood 104(8):2523\u20132531","DOI":"10.1182\/blood-2003-12-4251"},{"key":"10_CR120","doi-asserted-by":"crossref","unstructured":"Siu YT, Chin KT, Siu KL, Yee Wai CE, Jeang KT, Jin DY (2006) Torc1 and Torc2 coactivators are required for Tax activation of the human T-Cell leukemia virus type 1 long terminal repeats. J Virol 80(14):7052\u20137059","DOI":"10.1128\/JVI.00103-06"},{"key":"10_CR121","doi-asserted-by":"publisher","unstructured":"Sun SC (2012) The noncanonical NF-kappaB pathway. Immunol Rev 246(1):125\u20131240. https:\/\/doi.org\/10.1111\/J.1600-065x.2011.01088.X. Pubmed Pmid: 22435551; Pubmed Central Pmcid: Pmc3313452","DOI":"10.1111\/J.1600-065x.2011.01088.X"},{"key":"10_CR122","doi-asserted-by":"publisher","unstructured":"Takahashi M, Higuchi M, Makokha GN, Matsuki H, Yoshita M, Tanaka Y et al (2013) HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10. Blood 122(5):715\u2013725. https:\/\/doi.org\/10.1182\/blood-2013-03-493718. Pubmed Pmid: 23775713","DOI":"10.1182\/blood-2013-03-493718"},{"issue":"4","key":"10_CR123","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/ijc.20007","volume":"109","author":"S Takeda","year":"2004","unstructured":"Takeda S, Maeda M, Morikawa S, Taniguchi Y, Yasunaga J, Nosaka K et al (2004) Genetic and epigenetic inactivation of Tax gene in adult T-cell leukemia cells. Int J Cancer 109(4):559\u2013567","journal-title":"Int J Cancer"},{"key":"10_CR124","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1073\/pnas.87.3.1071","volume":"87","author":"A Tanaka","year":"1990","unstructured":"Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, Hatanaka M (1990) Oncogenic transformation by the Tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci U S A 87:1071\u20131075","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10_CR125","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1086\/428625","volume":"191","author":"G Tanaka","year":"2005","unstructured":"Tanaka G, Okayama A, Watanabe T, Aizawa S, Stuver S, Mueller N et al (2005) The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers. J Infect Dis 191(7):1140\u20131147","journal-title":"J Infect Dis"},{"key":"10_CR126","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1742-4690-2-64","volume":"2","author":"Y Taniguchi","year":"2005","unstructured":"Taniguchi Y, Nosaka K, Yasunaga J, Maeda M, Mueller N, Okayama A et al (2005) Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology 2:64","journal-title":"Retrovirology"},{"key":"10_CR127","doi-asserted-by":"publisher","unstructured":"Tao Z, Ghosh G (2012) Understanding NIK regulation from its structure. Structure\u00a020(10):1615\u20131617. https:\/\/doi.org\/10.1016\/J.Str.2012.09.012. Pubmed Pmid: 23063006","DOI":"10.1016\/J.Str.2012.09.012"},{"key":"10_CR128","unstructured":"Taylor GP, Matsuoka M (2005) Natural History of adult T-cell leukemia\/lymphoma and approaches to therapy. Oncogene 24(39):6047\u20136057"},{"key":"10_CR129","doi-asserted-by":"publisher","unstructured":"Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N et al (2014) An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood 123(3):346\u2013355. Blood-2013-06-508861 [Pii]; https:\/\/doi.org\/10.1182\/blood-2013-06-508861 [Doi]","DOI":"10.1182\/blood-2013-06-508861"},{"issue":"22","key":"10_CR130","doi-asserted-by":"publisher","first-page":"14069","DOI":"10.1128\/JVI.79.22.14069-14078.2005","volume":"79","author":"A Tripp","year":"2005","unstructured":"Tripp A, Banerjee P, Sieburg M, Planelles V, Li F, Feuer G (2005) Induction of cell cycle arrest by human T-Cell lymphotropic virus type 1 Tax in hematopoietic progenitor (Cd34+) cells: modulation of P21CIP1\/WAF1 and P27KIP1 expression. Jvirol. 79(22):14069\u201314078","journal-title":"Jvirol."},{"key":"10_CR131","unstructured":"Tsukahara T, Kannagi M, Ohashi T, Kato H, Arai M, Nunez G et al (1999) Induction of BCL-X(L) expression by human T-cell leukemia virus type 1 Tax through NF-KappaB in apoptosis-resistant T-cell transfectants with Tax. J Virol 73(10):7981\u20137987. Pubmed Pmid: 10482545; Pubmed Central Pmcid: Pmcpmc112812"},{"key":"10_CR132","doi-asserted-by":"publisher","unstructured":"Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W Jr et al (2009) Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol 27(3):453\u2013459. Doi:Jco.2008.18.2428 [Pii]; https:\/\/doi.org\/10.1200\/jco.2008.18.2428 [Doi]","DOI":"10.1200\/jco.2008.18.2428"},{"key":"10_CR133","doi-asserted-by":"publisher","unstructured":"Umeki K, Hisada M, Maloney EM, Hanchard B, Okayama A (2009) Proviral loads and clonal expansion of HTLV-1-infected cells following vertical transmission: a 10-year follow-up of children in jamaica. Inter Virol 52(3):115\u2013122. Doi:000219384 [Pii]; https:\/\/doi.org\/10.1159\/000219384 [Doi]","DOI":"10.1159\/000219384"},{"key":"10_CR134","doi-asserted-by":"publisher","unstructured":"Ungewickell A, Bhaduri A, Rios E, Reuter J, Lee CS, Mah A et al (2015) Genomic analysis of mycosis fungoides and sezary syndrome identifies recurrent alterations in TNFR2. Nat Gen 47(9):1056\u201360. https:\/\/doi.org\/10.1038\/ng.3370. Pubmed Pmid: 26258847","DOI":"10.1038\/ng.3370"},{"key":"10_CR135","doi-asserted-by":"publisher","unstructured":"Van Prooyen N, Andresen V, Gold H, Bialuk I, Pise-Masison C, Franchini G (2010) Hijacking the T-cell communication network by the human T-cell leukemia\/lymphoma virus type 1 (HTLV-1) P12 and P8 proteins. Mol Aspects Med 31(5):333\u2013343. Epub 2010\/08\/03. https:\/\/doi.org\/10.1016\/j.mam.2010.07.001. Pubmed Pmid: 20673780; Pubmed Central Pmcid: Pmcpmc2967610","DOI":"10.1016\/j.mam.2010.07.001"},{"key":"10_CR136","doi-asserted-by":"publisher","unstructured":"Vernin C, Thenoz M, Pinatel C, Gessain A, Gout O, Delfau-Larue MH et al (2014) HTLV-1 bZip factor hbz promotes cell proliferation and genetic instability by activating oncomirs. Cancer Res 74(21):6082\u20136093. https:\/\/doi.org\/10.1158\/0008-5472.Can-13-3564. Pubmed Pmid: 25205102","DOI":"10.1158\/0008-5472.Can-13-3564"},{"key":"10_CR137","doi-asserted-by":"publisher","unstructured":"Wang L, Ni X, Covington KR, Yang By, Shiu J, Zhang X (2015) Genomic profiling of sezary syndrome identifies alterations of key T cell signaling and differentiation genes. Nat Gen 47(12):1426\u20131434. https:\/\/doi.org\/10.1038\/ng.3444. Pubmed Pmid: 26551670; Pubmed Central Pmcid: Pmcpmc4829974","DOI":"10.1038\/ng.3444"},{"key":"10_CR138","doi-asserted-by":"publisher","unstructured":"Wang C, Long W, Peng C, Hu L, Zhang Q, Wu A, et al (2016) HTLV-1 Tax functions as a ubiquitin E3 ligase for direct IKK activation via synthesis of mixed-linkage polyubiquitin chains. Plos Pathog 12(4):E1005584. https:\/\/doi.org\/10.1371\/Journal.Ppat.1005584. Pubmed Pmid: 27082114; Pubmed Central Pmcid: Pmcpmc4833305","DOI":"10.1371\/Journal.Ppat.1005584"},{"key":"10_CR139","doi-asserted-by":"publisher","unstructured":"Watanabe T (2017) Adult T-Cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells. Blood 129(9):1071\u20131081. Epub 2017\/01\/25. https:\/\/doi.org\/10.1182\/blood-2016-09-692574. Pubmed Pmid: 28115366; Pubmed Central Pmcid: Pmcpmc5374731","DOI":"10.1182\/blood-2016-09-692574"},{"key":"10_CR140","doi-asserted-by":"crossref","unstructured":"Wu X, Sun SC (2007) Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. Embo Rep 8(5):510\u2013515","DOI":"10.1038\/sj.embor.7400931"},{"key":"10_CR141","doi-asserted-by":"crossref","unstructured":"Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M et al (2001) Retroviral oncoprotein Tax induces processing of NF-kappaB2\/P100 in T Cells: evidence for the involvement of Ikkalpha. Embo J 20(23):6805\u20136815","DOI":"10.1093\/emboj\/20.23.6805"},{"key":"10_CR142","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1128\/JVI.68.5.3374-3379.1994","volume":"68","author":"T Yamada","year":"1994","unstructured":"Yamada T, Yamaoka S, Goto T, Nakai M, Tsujimoto Y, Hatanaka M (1994) The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the BCL-2 protein. Jvirol. 68:3374\u20133379","journal-title":"Jvirol."},{"key":"10_CR143","doi-asserted-by":"publisher","unstructured":"Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K (2013) HTLV-1 bZip factor induces inflammation through labile Foxp3 expression. PLoS Pathog 9(9):E1003630. https:\/\/doi.org\/10.1371\/Journal.Ppat.1003630. Pubmed Pmid: 24068936; Pubmed Central Pmcid: Pmc3777874","DOI":"10.1371\/Journal.Ppat.1003630"},{"key":"10_CR144","first-page":"433","volume":"7","author":"S Yamaoka","year":"1992","unstructured":"Yamaoka S, Tobe T, Hatanaka M (1992) Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype. Oncogene 7:433\u2013437","journal-title":"Oncogene"},{"key":"10_CR145","doi-asserted-by":"crossref","unstructured":"Yamaoka S, Inoue H, Sakurai M, Sugiyama T, Hazama M, Yamada T et al (1996) Constitutive activation of NF-kappaB is essential for transformation of RAT fibroblasts by the human T-cell leukemia virus type I Tax protein. Embo J 15(4):873\u2013887","DOI":"10.1002\/j.1460-2075.1996.tb00422.x"},{"key":"10_CR146","doi-asserted-by":"crossref","unstructured":"Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F et al (1998) Complementation cloning of nemo, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93(7):1231\u20131240","DOI":"10.1016\/S0092-8674(00)81466-X"},{"key":"10_CR147","doi-asserted-by":"publisher","unstructured":"Yang L, Kotomura N, Ho YK, Zhi H, Bixler S, Schell MJ et al (2011) Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax. J Virol. 85(6):3001\u20133009. Doi:Jvi.00086-10 [Pii]; https:\/\/doi.org\/10.1128\/jvi.00086-10 [Doi]","DOI":"10.1128\/jvi.00086-10"},{"key":"10_CR148","doi-asserted-by":"publisher","unstructured":"Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N et al (2016) HTLV-1 bZip factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and itim domain (Tigit). PLoS Pathog. 12(1):E1005372. https:\/\/doi.org\/10.1371\/Journal.Ppat.1005372. Pubmed Pmid: 26735971; Pubmed Central Pmcid: Pmcpmc4703212","DOI":"10.1371\/Journal.Ppat.1005372"},{"issue":"8","key":"10_CR149","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/sj.emboj.7601054","volume":"25","author":"Kuo Yl","year":"2006","unstructured":"Yl Kuo, Cz Giam (2006) Activation Of the anaphase promoting complex by HTLV-1 Tax leads to senescence. EMBO J 25(8):1741\u20131752","journal-title":"EMBO J"},{"issue":"19","key":"10_CR150","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.1128\/JVI.00242-08","volume":"82","author":"M Yoshida","year":"2008","unstructured":"Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M (2008) Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZip factor (HBZ) gene. Jvirol. 82(19):9359\u20139368","journal-title":"Jvirol."},{"key":"10_CR151","doi-asserted-by":"publisher","unstructured":"Yoshita M, Higuchi M, Takahashi M, Oie M, Tanaka Y, Fujii M (2012) Activation of MTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. Cancer Sci 103(2):369\u2013374. https:\/\/doi.org\/10.1111\/J.1349-7006.2011.02123.X Pubmed Pmid: 22010857","DOI":"10.1111\/J.1349-7006.2011.02123.X"},{"key":"10_CR152","doi-asserted-by":"publisher","unstructured":"Zahoor MA, Philip S, Zhi H, Giam CZ (2014) NF-KappaB inhibition facilitates the establishment of cell lines that chronically produce human T-lymphotropic virus type 1 viral particles. J Virol 88(6):3496\u20133504. Doi:Jvi.02961-13 [Pii]; https:\/\/doi.org\/10.1128\/jvi.02961-13 [Doi]","DOI":"10.1128\/jvi.02961-13"},{"key":"10_CR153","doi-asserted-by":"crossref","unstructured":"Zhang L, Zhi H, Liu M, Kuo YL, Giam CZ (2009) Induction of P21(CIP1\/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization. Retrovirology 6:35","DOI":"10.1186\/1742-4690-6-35"},{"issue":"12","key":"10_CR154","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1182\/blood-2008-06-161729","volume":"113","author":"T Zhao","year":"2009","unstructured":"Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, Fujii M et al (2009) Human T-cell leukemia virus type 1 bZip factor selectively suppresses the classical pathway of NF-KappaB. Blood 113(12):2755\u20132764","journal-title":"Blood"},{"key":"10_CR01","doi-asserted-by":"crossref","unstructured":"Zhao LJ, Giam CZ (1992) Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc Natl Acad Sci USA 89:7070\u20137074","DOI":"10.1073\/pnas.89.15.7070"},{"key":"10_CR155","doi-asserted-by":"publisher","unstructured":"Zhao T, Satou Y, Matsuoka M (2014) Development of T cell lymphoma in HTLV-1 bZip factor and Tax double transgenic mice. Arch Virol 159(7):1849\u20131856. Epub 2014\/05\/14. https:\/\/doi.org\/10.1007\/s00705-014-2099-y. Pubmed Pmid: 24818712","DOI":"10.1007\/s00705-014-2099-y"},{"key":"10_CR156","doi-asserted-by":"publisher","unstructured":"Zhi H, Yang L, Kuo Yl, Ho YK, Shih HM, Giam CZ (2011) NF-KappaB hyper-activation by HTLV-1 Tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4):E1002025. https:\/\/doi.org\/10.1371\/journal.ppat.1002025 [Doi]","DOI":"10.1371\/journal.ppat.1002025"},{"key":"10_CR157","doi-asserted-by":"publisher","unstructured":"Zhi H, Zahoor MA, Shudofsky AM, Giam CZ (2014) KSHV vcyclin counters the senescence\/G1 arrest response triggered by NF-KappaB hyperactivation. Oncogene. Doi:Onc2013567 [Pii]; https:\/\/doi.org\/10.1038\/onc.2013.567 [Doi]","DOI":"10.1038\/onc.2013.567"},{"key":"10_CR08","doi-asserted-by":"crossref","unstructured":"Zhi H, Guo X, Ho YK, Pasupala N, Engstrom HAA, Semmes OJ et al (2020) RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia. PLoS Pathog 16(5):e1008618. Epub 2020\/05\/27. https:\/\/doi.org\/10.1371\/journal.ppat.1008618. PubMed PMID: 32453758","DOI":"10.1371\/journal.ppat.1008618"}],"container-title":["Recent Results in Cancer Research","Viruses and Human Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-57362-1_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:16:10Z","timestamp":1669630570000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-57362-1_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"ISBN":["9783030573614","9783030573621"],"references-count":163,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-57362-1_10","relation":{},"ISSN":["0080-0015","2197-6767"],"issn-type":[{"value":"0080-0015","type":"print"},{"value":"2197-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"18 November 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}