{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:54:45Z","timestamp":1773687285868,"version":"3.50.1"},"publisher-location":"Cham","reference-count":101,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030602031","type":"print"},{"value":"9783030602048","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-60204-8_11","type":"book-chapter","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T11:12:58Z","timestamp":1610104378000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Drosophila melanogaster as Genetic Model System to Dissect the Mechanisms of Disease that Lead to Neurodegeneration in Adrenoleukodystrophy"],"prefix":"10.1007","author":[{"given":"Margret H.","family":"B\u00fclow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon D.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Di Cara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"issue":"3","key":"11_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1242\/dmm.023762","volume":"9","author":"B Ugur","year":"2016","unstructured":"Ugur B, Chen K, Bellen HJ (2016) Drosophila tools and assays for the study of human diseases. Dis Model Mech 9(3):235\u2013244","journal-title":"Dis Model Mech"},{"issue":"3","key":"11_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/BF00684595","volume":"19","author":"MM Herman","year":"1971","unstructured":"Herman MM, Miquel J, Johnson M (1971) Insect brain as a model for the study of aging. Age-related changes in drosophila melanogaster. Acta Neuropathol 19(3):167\u2013183","journal-title":"Acta Neuropathol"},{"issue":"3","key":"11_CR3","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S0896-6273(00)80573-5","volume":"21","author":"GR Jackson","year":"1998","unstructured":"Jackson GR et al (1998) Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 21(3):633\u2013642","journal-title":"Neuron"},{"issue":"3","key":"11_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.mcn.2004.03.001","volume":"26","author":"A Finelli","year":"2004","unstructured":"Finelli A et al (2004) A model for studying Alzheimer\u2019s Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci 26(3):365\u2013375","journal-title":"Mol Cell Neurosci"},{"issue":"6776","key":"11_CR5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/35006074","volume":"404","author":"MB Feany","year":"2000","unstructured":"Feany MB, Bender WW (2000) A drosophila model of Parkinson\u2019s disease. Nature 404(6776):394\u2013398","journal-title":"Nature"},{"issue":"3","key":"11_CR6","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1534\/genetics.115.183392","volume":"201","author":"KG Hales","year":"2015","unstructured":"Hales KG et al (2015) Genetics on the Fly: a primer on the Drosophila model system. Genetics 201(3):815\u2013842","journal-title":"Genetics"},{"issue":"2","key":"11_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1534\/genetics.115.179457","volume":"201","author":"L McGurk","year":"2015","unstructured":"McGurk L, Berson A, Bonini NM (2015) Drosophila as an in vivo model for human neurodegenerative disease. Genetics 201(2):377\u2013402","journal-title":"Genetics"},{"issue":"2","key":"11_CR8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1242\/dmm.027680","volume":"10","author":"MF Wangler","year":"2017","unstructured":"Wangler MF, Hu Y, Shulman JM (2017) Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech 10(2):77\u201388","journal-title":"Dis Model Mech"},{"issue":"5","key":"11_CR9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.bbadis.2016.06.015","volume":"1863","author":"SK Jha","year":"2017","unstructured":"Jha SK et al (2017) Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration. Biochim Biophys Acta Mol basis Dis 1863(5):1132\u20131146","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"11","key":"11_CR10","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1002\/jnr.24064","volume":"95","author":"Y Zilberter","year":"2017","unstructured":"Zilberter Y, Zilberter M (2017) The vicious circle of hypometabolism in neurodegenerative diseases: ways and mechanisms of metabolic correction. J Neurosci Res 95(11):2217\u20132235","journal-title":"J Neurosci Res"},{"issue":"8","key":"11_CR11","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1136\/archdischild-2012-302840","volume":"98","author":"G Pierre","year":"2013","unstructured":"Pierre G (2013) Neurodegenerative disorders and metabolic disease. Arch Dis Child 98(8):618\u2013624","journal-title":"Arch Dis Child"},{"issue":"17","key":"11_CR12","doi-asserted-by":"publisher","first-page":"i981","DOI":"10.1093\/bioinformatics\/bty604","volume":"34","author":"G Sambamoorthy","year":"2018","unstructured":"Sambamoorthy G, Raman K (2018) Understanding the evolution of functional redundancy in metabolic networks. Bioinformatics 34(17):i981\u2013i987","journal-title":"Bioinformatics"},{"issue":"5","key":"11_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1242\/dmm.007419","volume":"4","author":"FD Mast","year":"2011","unstructured":"Mast FD et al (2011) A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Dis Model Mech 4(5):659\u2013672","journal-title":"Dis Model Mech"},{"issue":"4","key":"11_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1242\/dmm.022244","volume":"9","author":"A Sivachenko","year":"2016","unstructured":"Sivachenko A et al (2016) Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the bubblegum and double bubble acyl-CoA synthetases. Dis Model Mech 9(4):377\u2013387","journal-title":"Dis Model Mech"},{"issue":"5422","key":"11_CR15","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1126\/science.284.5422.1985","volume":"284","author":"KT Min","year":"1999","unstructured":"Min KT, Benzer S (1999) Preventing neurodegeneration in the drosophila mutant bubblegum. Science 284(5422):1985\u20131988","journal-title":"Science"},{"issue":"6","key":"11_CR16","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.031286","volume":"11","author":"HB Gordon","year":"2018","unstructured":"Gordon HB, Valdez L, Letsou A (2018) Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Dis Model Mech 11(6):dmm031286","journal-title":"Dis Model Mech"},{"issue":"45","key":"11_CR17","doi-asserted-by":"publisher","first-page":"35162","DOI":"10.1074\/jbc.M006403200","volume":"275","author":"SJ Steinberg","year":"2000","unstructured":"Steinberg SJ et al (2000) Very long-chain acyl-CoA synthetases. Human \"bubblegum\" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem 275(45):35162\u201335169","journal-title":"J Biol Chem"},{"issue":"3","key":"11_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002275","volume":"14","author":"C Brayne","year":"2017","unstructured":"Brayne C, Miller B (2017) Dementia and aging populations-a global priority for contextualized research and health policy. PLoS Med 14(3):e1002275","journal-title":"PLoS Med"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"T Fulop","year":"2017","unstructured":"Fulop T et al (2017) Immunosenescence and Inflamm-aging as two sides of the same coin: friends or foes? Front Immunol 8:1960","journal-title":"Front Immunol"},{"key":"11_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.12688\/f1000research.13117.1","volume":"7","author":"K Garschall","year":"2018","unstructured":"Garschall K, Flatt T (2018) The interplay between immunity and aging in drosophila. F1000Res 7:160","journal-title":"F1000Res"},{"issue":"4","key":"11_CR21","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.celrep.2017.04.007","volume":"19","author":"I Kounatidis","year":"2017","unstructured":"Kounatidis I et al (2017) NF-kappaB immunity in the brain determines Fly lifespan in healthy aging and age-related Neurodegeneration. Cell Rep 19(4):836\u2013848","journal-title":"Cell Rep"},{"key":"11_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1146\/annurev-ento-011118-112007","volume":"64","author":"S Li","year":"2019","unstructured":"Li S, Yu X, Feng Q (2019) Fat body biology in the last decade. Annu Rev Entomol 64:315\u2013333","journal-title":"Annu Rev Entomol"},{"key":"11_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/601587","volume":"2013","author":"S Matsuda","year":"2013","unstructured":"Matsuda S, Kitagishi Y, Kobayashi M (2013) Function and characteristics of PINK1 in mitochondria. Oxidative Med Cell Longev 2013:601587","journal-title":"Oxidative Med Cell Longev"},{"key":"11_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2982","volume":"4","author":"BE Riley","year":"2013","unstructured":"Riley BE et al (2013) Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun 4:1982","journal-title":"Nat Commun"},{"issue":"7097","key":"11_CR25","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/nature04779","volume":"441","author":"IE Clark","year":"2006","unstructured":"Clark IE et al (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441(7097):1162\u20131166","journal-title":"Nature"},{"issue":"7097","key":"11_CR26","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/nature04788","volume":"441","author":"J Park","year":"2006","unstructured":"Park J et al (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441(7097):1157\u20131161","journal-title":"Nature"},{"issue":"3","key":"11_CR27","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.bbrc.2008.10.104","volume":"377","author":"Y Kim","year":"2008","unstructured":"Kim Y et al (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 377(3):975\u2013980","journal-title":"Biochem Biophys Res Commun"},{"issue":"32","key":"11_CR28","doi-asserted-by":"publisher","first-page":"8563","DOI":"10.1523\/JNEUROSCI.0218-07.2007","volume":"27","author":"C Wang","year":"2007","unstructured":"Wang C et al (2007) Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. J Neurosci 27(32):8563\u20138570","journal-title":"J Neurosci"},{"issue":"5","key":"11_CR29","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1083\/jcb.201801044","volume":"217","author":"JJ Lee","year":"2018","unstructured":"Lee JJ et al (2018) Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin. J Cell Biol 217(5):1613\u20131622","journal-title":"J Cell Biol"},{"key":"11_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.nbd.2017.04.014","volume":"104","author":"H Julienne","year":"2017","unstructured":"Julienne H et al (2017) Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson\u2019s disease phenotypes. Neurobiol Dis 104:15\u201323","journal-title":"Neurobiol Dis"},{"key":"11_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/ijms19123911","volume":"19","author":"F De Lazzari","year":"2018","unstructured":"De Lazzari F et al (2018) Circadian rhythm abnormalities in Parkinson\u2019s disease from humans to flies and Back. Int J Mol Sci 19:12","journal-title":"Int J Mol Sci"},{"issue":"3","key":"11_CR32","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nrg751","volume":"3","author":"D St Johnston","year":"2002","unstructured":"St Johnston D (2002) The art and design of genetic screens: Drosophila melanogaster. Nat Rev Genet 3(3):176\u2013188","journal-title":"Nat Rev Genet"},{"key":"11_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/srep23102","volume":"6","author":"S Burnouf","year":"2016","unstructured":"Burnouf S et al (2016) Deletion of endogenous Tau proteins is not detrimental in Drosophila. Sci Rep 6:23102","journal-title":"Sci Rep"},{"issue":"4","key":"11_CR34","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.neuron.2018.01.022","volume":"97","author":"J McInnes","year":"2018","unstructured":"McInnes J et al (2018) Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau. Neuron 97(4):823\u2013835 e8","journal-title":"Neuron"},{"issue":"49","key":"11_CR35","doi-asserted-by":"publisher","first-page":"11881","DOI":"10.1523\/JNEUROSCI.0862-17.2017","volume":"37","author":"A Ray","year":"2017","unstructured":"Ray A, Speese SD, Logan MA (2017) Glial Draper rescues Abeta toxicity in a Drosophila model of Alzheimer\u2019s disease. J Neurosci 37(49):11881\u201311893","journal-title":"J Neurosci"},{"issue":"36","key":"11_CR36","doi-asserted-by":"publisher","first-page":"24972","DOI":"10.1074\/jbc.M804817200","volume":"283","author":"MR Watson","year":"2008","unstructured":"Watson MR et al (2008) A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. J Biol Chem 283(36):24972\u201324981","journal-title":"J Biol Chem"},{"issue":"1","key":"11_CR37","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuron.2017.11.036","volume":"97","author":"DG Ordonez","year":"2018","unstructured":"Ordonez DG, Lee MK, Feany MB (2018) Alpha-synuclein induces mitochondrial dysfunction through Spectrin and the actin cytoskeleton. Neuron 97(1):108\u2013124 e6","journal-title":"Neuron"},{"issue":"10","key":"11_CR38","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/glia.23671","volume":"67","author":"AL Olsen","year":"2019","unstructured":"Olsen AL, Feany MB (2019) Glial alpha-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo. Glia 67(10):1933\u20131957","journal-title":"Glia"},{"issue":"11","key":"11_CR39","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020552","volume":"7","author":"MR Freeman","year":"2015","unstructured":"Freeman MR (2015) Drosophila central nervous system glia. Cold Spring Harb Perspect Biol 7(11):a020552","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1165","key":"11_CR40","first-page":"1","volume":"314","author":"JG White","year":"1986","unstructured":"White JG et al (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond Ser B Biol Sci 314(1165):1\u2013340","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"11_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24394","volume":"6","author":"SY Takemura","year":"2017","unstructured":"Takemura SY et al (2017) The comprehensive connectome of a neural substrate for \u2018ON\u2019 motion detection in Drosophila. elife 6:e24394","journal-title":"elife"},{"issue":"10","key":"11_CR42","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/s41593-018-0221-2","volume":"21","author":"H Fu","year":"2018","unstructured":"Fu H, Hardy J, Duff KE (2018) Selective vulnerability in neurodegenerative diseases. Nat Neurosci 21(10):1350\u20131358","journal-title":"Nat Neurosci"},{"issue":"4","key":"11_CR43","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.neuron.2013.12.017","volume":"81","author":"K Ito","year":"2014","unstructured":"Ito K et al (2014) A systematic nomenclature for the insect brain. Neuron 81(4):755\u2013765","journal-title":"Neuron"},{"issue":"6129","key":"11_CR44","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1126\/science.1231828","volume":"340","author":"NJ Strausfeld","year":"2013","unstructured":"Strausfeld NJ, Hirth F (2013) Deep homology of arthropod central complex and vertebrate basal ganglia. Science 340(6129):157\u2013161","journal-title":"Science"},{"issue":"Database issue","key":"11_CR45","doi-asserted-by":"publisher","first-page":"D780","DOI":"10.1093\/nar\/gkt1092","volume":"42","author":"SE St Pierre","year":"2014","unstructured":"St Pierre SE et al (2014) FlyBase 102--advanced approaches to interrogating FlyBase. Nucleic Acids Res 42(Database issue):D780\u2013D788","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"11_CR46","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.tins.2010.07.001","volume":"33","author":"S Waddell","year":"2010","unstructured":"Waddell S (2010) Dopamine reveals neural circuit mechanisms of fly memory. Trends Neurosci 33(10):457\u2013464","journal-title":"Trends Neurosci"},{"key":"11_CR47","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.conb.2018.10.007","volume":"54","author":"AS Thum","year":"2019","unstructured":"Thum AS, Gerber B (2019) Connectomics and function of a memory network: the mushroom body of larval Drosophila. Curr Opin Neurobiol 54:146\u2013154","journal-title":"Curr Opin Neurobiol"},{"issue":"4","key":"11_CR48","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.celrep.2013.10.032","volume":"5","author":"T Riemensperger","year":"2013","unstructured":"Riemensperger T et al (2013) A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep 5(4):952\u2013960","journal-title":"Cell Rep"},{"key":"11_CR49","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/ijms19113343","volume":"19","author":"E Nagoshi","year":"2018","unstructured":"Nagoshi E (2018) Drosophila models of sporadic Parkinson\u2019s disease. Int J Mol Sci 19:11","journal-title":"Int J Mol Sci"},{"issue":"5461","key":"11_CR50","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1126\/science.287.5461.2204","volume":"287","author":"GM Rubin","year":"2000","unstructured":"Rubin GM et al (2000) Comparative genomics of the eukaryotes. Science 287(5461):2204\u20132215","journal-title":"Science"},{"issue":"1","key":"11_CR51","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrg1503","volume":"6","author":"E Bier","year":"2005","unstructured":"Bier E (2005) Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 6(1):9\u201323","journal-title":"Nat Rev Genet"},{"issue":"5461","key":"11_CR52","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","volume":"287","author":"MD Adams","year":"2000","unstructured":"Adams MD et al (2000) The genome sequence of Drosophila melanogaster. Science 287(5461):2185\u20132195","journal-title":"Science"},{"issue":"2","key":"11_CR53","doi-asserted-by":"publisher","first-page":"R267","DOI":"10.1093\/hmg\/ddh248","volume":"13","author":"RJ Greenspan","year":"2004","unstructured":"Greenspan RJ, Dierick HA (2004) \u2018Am not I a fly like thee?\u2019 from genes in fruit flies to behavior in humans. Hum Mol Genet 13(2):R267\u2013R273","journal-title":"Hum Mol Genet"},{"issue":"2","key":"11_CR54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S1383-5742(98)00027-1","volume":"436","author":"KH Baek","year":"1999","unstructured":"Baek KH (1999) The first oncogene in Drosophila melanogaster. Mutat Res 436(2):131\u2013136","journal-title":"Mutat Res"},{"issue":"5785","key":"11_CR55","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/287795a0","volume":"287","author":"C Nusslein-Volhard","year":"1980","unstructured":"Nusslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in drosophila. Nature 287(5785):795\u2013801","journal-title":"Nature"},{"issue":"1","key":"11_CR56","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ymeth.2014.01.001","volume":"68","author":"O Tataroglu","year":"2014","unstructured":"Tataroglu O, Emery P (2014) Studying circadian rhythms in Drosophila melanogaster. Methods 68(1):140\u2013150","journal-title":"Methods"},{"issue":"6","key":"11_CR57","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","volume":"86","author":"B Lemaitre","year":"1996","unstructured":"Lemaitre B et al (1996) The dorsoventral regulatory gene cassette spatzle\/toll\/cactus controls the potent antifungal response in Drosophila adults. Cell 86(6):973\u2013983","journal-title":"Cell"},{"issue":"1","key":"11_CR58","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.dci.2013.05.014","volume":"42","author":"A Kleino","year":"2014","unstructured":"Kleino A, Silverman N (2014) The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol 42(1):25\u201335","journal-title":"Dev Comp Immunol"},{"issue":"7","key":"11_CR59","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nrg2364","volume":"9","author":"M Boutros","year":"2008","unstructured":"Boutros M, Ahringer J (2008) The art and design of genetic screens: RNA interference. Nat Rev Genet 9(7):554\u2013566","journal-title":"Nat Rev Genet"},{"issue":"1","key":"11_CR60","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4161\/fly.4.1.11230","volume":"4","author":"KR Cook","year":"2010","unstructured":"Cook KR et al (2010) New research resources at the Bloomington Drosophila Stock Center. Fly (Austin) 4(1):88\u201391","journal-title":"Fly (Austin)"},{"issue":"5","key":"11_CR61","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nmeth.1592","volume":"8","author":"JQ Ni","year":"2011","unstructured":"Ni JQ et al (2011) A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods 8(5):405\u2013407","journal-title":"Nat Methods"},{"issue":"7150","key":"11_CR62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nature05954","volume":"448","author":"G Dietzl","year":"2007","unstructured":"Dietzl G et al (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in drosophila. Nature 448(7150):151\u2013156","journal-title":"Nature"},{"key":"11_CR63","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fnmol.2018.00124","volume":"11","author":"M Drozd","year":"2018","unstructured":"Drozd M, Bardoni B, Capovilla M, Modeling Fragile X (2018) Syndrome in Drosophila. Front Mol Neurosci 11:124","journal-title":"Front Mol Neurosci"},{"key":"11_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104535","volume":"132","author":"SL Johnson","year":"2019","unstructured":"Johnson SL et al (2019) Differential toxicity of ataxin-3 isoforms in drosophila models of Spinocerebellar ataxia type 3. Neurobiol Dis 132:104535","journal-title":"Neurobiol Dis"},{"issue":"2","key":"11_CR65","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118(2):401\u2013415","journal-title":"Development"},{"issue":"4","key":"11_CR66","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","volume":"2","author":"A Jenett","year":"2012","unstructured":"Jenett A et al (2012) A GAL4-driver line resource for Drosophila neurobiology. Cell Rep 2(4):991\u20131001","journal-title":"Cell Rep"},{"issue":"28","key":"11_CR67","doi-asserted-by":"publisher","first-page":"9715","DOI":"10.1073\/pnas.0803697105","volume":"105","author":"BD Pfeiffer","year":"2008","unstructured":"Pfeiffer BD et al (2008) Tools for neuroanatomy and neurogenetics in Drosophila. Proc Natl Acad Sci U S A 105(28):9715\u20139720","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"11_CR68","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.neuron.2006.08.028","volume":"52","author":"H Luan","year":"2006","unstructured":"Luan H et al (2006) Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression. Neuron 52(3):425\u2013436","journal-title":"Neuron"},{"issue":"5556","key":"11_CR69","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1126\/science.1067389","volume":"295","author":"PK Auluck","year":"2002","unstructured":"Auluck PK et al (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson\u2019s disease. Science 295(5556):865\u2013868","journal-title":"Science"},{"issue":"1","key":"11_CR70","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neuron.2013.02.029","volume":"78","author":"NC Kim","year":"2013","unstructured":"Kim NC et al (2013) VCP is essential for mitochondrial quality control by PINK1\/Parkin and this function is impaired by VCP mutations. Neuron 78(1):65\u201380","journal-title":"Neuron"},{"issue":"7198","key":"11_CR71","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/nature06909","volume":"453","author":"LB Li","year":"2008","unstructured":"Li LB et al (2008) RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature 453(7198):1107\u20131111","journal-title":"Nature"},{"issue":"5459","key":"11_CR72","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.287.5459.1837","volume":"287","author":"P Kazemi-Esfarjani","year":"2000","unstructured":"Kazemi-Esfarjani P, Benzer S (2000) Genetic suppression of polyglutamine toxicity in drosophila. Science 287(5459):1837\u20131840","journal-title":"Science"},{"key":"11_CR73","volume":"100","author":"ST Madabattula","year":"2015","unstructured":"Madabattula ST et al (2015) Quantitative analysis of climbing defects in a Drosophila model of neurodegenerative disorders. J Vis Exp 100:e52741","journal-title":"J Vis Exp"},{"issue":"1","key":"11_CR74","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nmeth.1800","volume":"9","author":"A del Valle Rodriguez","year":"2011","unstructured":"del Valle Rodriguez A, Didiano D, Desplan C (2011) Power tools for gene expression and clonal analysis in Drosophila. Nat Methods 9(1):47\u201355","journal-title":"Nat Methods"},{"issue":"4","key":"11_CR75","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1534\/genetics.117.300228","volume":"208","author":"JH Simpson","year":"2018","unstructured":"Simpson JH, Looger LL (2018) Functional imaging and Optogenetics in Drosophila. Genetics 208(4):1291\u20131309","journal-title":"Genetics"},{"issue":"2","key":"11_CR76","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/84397","volume":"19","author":"J Nakai","year":"2001","unstructured":"Nakai J, Ohkura M, Imoto K (2001) A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol 19(2):137\u2013141","journal-title":"Nat Biotechnol"},{"issue":"4","key":"11_CR77","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0896-6273(00)80955-1","volume":"19","author":"MS Siegel","year":"1997","unstructured":"Siegel MS, Isacoff EY (1997) A genetically encoded optical probe of membrane voltage. Neuron 19(4):735\u2013741","journal-title":"Neuron"},{"issue":"3","key":"11_CR78","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neuron.2007.11.030","volume":"57","author":"EH Feinberg","year":"2008","unstructured":"Feinberg EH et al (2008) GFP reconstitution across synaptic partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron 57(3):353\u2013363","journal-title":"Neuron"},{"issue":"3","key":"11_CR79","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1080\/19336934.2017.1295189","volume":"11","author":"D Lee","year":"2017","unstructured":"Lee D et al (2017) Methods to investigate the structure and connectivity of the nervous system. Fly (Austin) 11(3):224\u2013238","journal-title":"Fly (Austin)"},{"issue":"6","key":"11_CR80","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0235-17.2017","volume":"4","author":"S Sun","year":"2017","unstructured":"Sun S, Yu R, Wang S (2017) A neural signature encoding decisions under perceptual ambiguity. eNeuro 4(6):ENEURO.0235-17.2017","journal-title":"eNeuro"},{"issue":"24","key":"11_CR81","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.cub.2007.11.029","volume":"17","author":"RY Hwang","year":"2007","unstructured":"Hwang RY et al (2007) Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol 17(24):2105\u20132116","journal-title":"Curr Biol"},{"issue":"24","key":"11_CR82","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1001\/jama.294.24.3131","volume":"294","author":"HW Moser","year":"2005","unstructured":"Moser HW, Raymond GV, Dubey P (2005) Adrenoleukodystrophy: new approaches to a neurodegenerative disease. JAMA 294(24):3131\u20133134","journal-title":"JAMA"},{"issue":"6414","key":"11_CR83","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/361726a0","volume":"361","author":"J Mosser","year":"1993","unstructured":"Mosser J et al (1993) Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 361(6414):726\u2013730","journal-title":"Nature"},{"issue":"3","key":"11_CR84","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/1479-7364-3-3-281","volume":"3","author":"V Vasiliou","year":"2009","unstructured":"Vasiliou V, Vasiliou K, Nebert DW (2009) Human ATP-binding cassette (ABC) transporter family. Hum Genomics 3(3):281\u2013290","journal-title":"Hum Genomics"},{"issue":"9","key":"11_CR85","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.bbadis.2012.02.009","volume":"1822","author":"M Morita","year":"2012","unstructured":"Morita M, Imanaka T (2012) Peroxisomal ABC transporters: structure, function and role in disease. Biochim Biophys Acta 1822(9):1387\u20131396","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"11_CR86","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1006\/bbrc.1997.6340","volume":"232","author":"T Kobayashi","year":"1997","unstructured":"Kobayashi T et al (1997) Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem Biophys Res Commun 232(3):631\u2013636","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"11_CR87","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<829::AID-JNR19>3.0.CO;2-W","volume":"50","author":"S Forss-Petter","year":"1997","unstructured":"Forss-Petter S et al (1997) Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. J Neurosci Res 50(5):829\u2013843","journal-title":"J Neurosci Res"},{"key":"11_CR88","unstructured":"Moser HW, SKD, Moser AB, In The metabolic and molecular bases of inherited disease, E. C. R. Scriver et al. 1995, McGraw-Hill,: New York. p. 2325\u20132349"},{"key":"11_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-nutr-071813-105541","volume":"34","author":"TJ Grevengoed","year":"2014","unstructured":"Grevengoed TJ, Klett EL, Coleman RA (2014) Acyl-CoA metabolism and partitioning. Annu Rev Nutr 34:1\u201330","journal-title":"Annu Rev Nutr"},{"issue":"4","key":"11_CR90","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ng857","volume":"30","author":"I Meloni","year":"2002","unstructured":"Meloni I et al (2002) FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Nat Genet 30(4):436\u2013440","journal-title":"Nat Genet"},{"issue":"6","key":"11_CR91","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1523\/JNEUROSCI.3278-10.2011","volume":"31","author":"Z Liu","year":"2011","unstructured":"Liu Z et al (2011) Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. J Neurosci 31(6):2052\u20132063","journal-title":"J Neurosci"},{"issue":"4","key":"11_CR92","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1194\/jlr.M013292","volume":"52","author":"DL Golej","year":"2011","unstructured":"Golej DL et al (2011) Long-chain acyl-CoA synthetase 4 modulates prostaglandin E(2) release from human arterial smooth muscle cells. J Lipid Res 52(4):782\u2013793","journal-title":"J Lipid Res"},{"key":"11_CR93","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.plipres.2015.08.001","volume":"60","author":"P Dourlen","year":"2015","unstructured":"Dourlen P et al (2015) Fatty acid transport proteins in disease: new insights from invertebrate models. Prog Lipid Res 60:30\u201340","journal-title":"Prog Lipid Res"},{"issue":"3","key":"11_CR94","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1055\/s-0034-1386769","volume":"34","author":"HB Gordon","year":"2014","unstructured":"Gordon HB, Letsou A, Bonkowsky JL (2014) The leukodystrophies. Semin Neurol 34(3):312\u2013320","journal-title":"Semin Neurol"},{"issue":"3","key":"11_CR95","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1023\/A:1005336726127","volume":"21","author":"RJ Wanders","year":"1998","unstructured":"Wanders RJ et al (1998) X-linked adrenoleukodystrophy: improved prenatal diagnosis using both biochemical and immunological methods. J Inherit Metab Dis 21(3):285\u2013287","journal-title":"J Inherit Metab Dis"},{"issue":"1-2","key":"11_CR96","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ymgme.2004.06.015","volume":"83","author":"Z Jia","year":"2004","unstructured":"Jia Z et al (2004) X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol Genet Metab 83(1-2):117\u2013127","journal-title":"Mol Genet Metab"},{"issue":"1","key":"11_CR97","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1042\/bj20031062","volume":"377","author":"P Fraisl","year":"2004","unstructured":"Fraisl P et al (2004) Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase. Biochem J 377(1):85\u201393","journal-title":"Biochem J"},{"issue":"10","key":"11_CR98","doi-asserted-by":"publisher","first-page":"6632","DOI":"10.1074\/jbc.M511558200","volume":"281","author":"Z Pei","year":"2006","unstructured":"Pei Z, Jia Z, Watkins PA (2006) The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase. J Biol Chem 281(10):6632\u20136641","journal-title":"J Biol Chem"},{"issue":"6","key":"11_CR99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004893","volume":"16","author":"J Sellin","year":"2018","unstructured":"Sellin J et al (2018) Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PLoS Biol 16(6):e2004893","journal-title":"PLoS Biol"},{"issue":"10","key":"11_CR100","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1093\/hmg\/ddg126","volume":"12","author":"AK Heinzer","year":"2003","unstructured":"Heinzer AK et al (2003) A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy. Hum Mol Genet 12(10):1145\u20131154","journal-title":"Hum Mol Genet"},{"issue":"26","key":"11_CR101","doi-asserted-by":"publisher","first-page":"19269","DOI":"10.1074\/jbc.M112.445445","volume":"288","author":"C Wiesinger","year":"2013","unstructured":"Wiesinger C et al (2013) Impaired very long-chain acyl-CoA beta-oxidation in human X-linked adrenoleukodystrophy fibroblasts is a direct consequence of ABCD1 transporter dysfunction. J Biol Chem 288(26):19269\u201319279","journal-title":"J Biol Chem"}],"container-title":["Advances in Experimental Medicine and Biology","Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-60204-8_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:58:05Z","timestamp":1670720285000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-60204-8_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030602031","9783030602048"],"references-count":101,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-60204-8_11","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"9 January 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}