{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:41:19Z","timestamp":1790440879406,"version":"4.1.0"},"publisher-location":"Cham","reference-count":34,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030602031","type":"print"},{"value":"9783030602048","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-60204-8_3","type":"book-chapter","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T11:12:58Z","timestamp":1610104378000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["7-Ketocholesterol- and 7\u03b2-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration"],"prefix":"10.1007","author":[{"given":"Thomas","family":"Nury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Yammine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Menetrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Zarrouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vejux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Lizard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"issue":"4","key":"3_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00418-008-0396-9","volume":"129","author":"M Schrader","year":"2008","unstructured":"Schrader M, Fahimi HD (2008) The peroxisome: still a mysterious organelle. Histochem Cell Biol 129(4):421\u2013440","journal-title":"Histochem Cell Biol"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0074-7696(06)55005-3","volume":"255","author":"M Schrader","year":"2006","unstructured":"Schrader M, Fahimi HD (2006) Growth and division of peroxisomes. Int Rev Cytol 255:237\u2013290","journal-title":"Int Rev Cytol"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fcell.2015.00035","volume":"3","author":"C Lismont","year":"2015","unstructured":"Lismont C, Nordgren M, Van Veldhoven PP, Fransen M (2015) Redox interplay between mitochondria and peroxisomes. Front Cell Dev Biol 3:35","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"3_CR4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jemt.10330","volume":"61","author":"M Depreter","year":"2003","unstructured":"Depreter M, Espeel M, Roels F (2003) Human peroxisomal disorders. Microsc Res Tech 61(2):203\u2013223","journal-title":"Microsc Res Tech"},{"issue":"10","key":"3_CR5","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrendo.2016.90","volume":"12","author":"S Kemp","year":"2016","unstructured":"Kemp S, Huffnagel IC, Linthorst GE, Wanders RJ, Engelen M (2016) Adrenoleukodystrophy - neuroendocrine pathogenesis and redefinition of natural history. Nat Rev Endocrinol 12(10):606\u2013615","journal-title":"Nat Rev Endocrinol"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.biochi.2013.11.023","volume":"98","author":"J Berger","year":"2014","unstructured":"Berger J, Forss-Petter S, Eichler FS (2014) Pathophysiology of X-linked adrenoleukodystrophy. Biochimie 98:135\u2013142","journal-title":"Biochimie"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1750-1172-7-51","volume":"7","author":"M Engelen","year":"2012","unstructured":"Engelen M, Kemp S, de Visser M, van Geel BM, Wanders RJ, Aubourg P, Poll-The BT (2012) X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management. Orphanet J Rare Dis 7:51","journal-title":"Orphanet J Rare Dis"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2012.03.058","volume":"213","author":"M Baarine","year":"2012","unstructured":"Baarine M, Andr\u00e9oletti P, Athias A, Nury T, Zarrouk A, Ragot K, Vejux A, Riedinger JM, Kattan Z, Bessede G, Trompier D, Savary S, Cherkaoui-Malki M, Lizard G (2012) Evidence of oxidative stress in very long chain fatty acid\u2014treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neuroscience 213:1\u201318","journal-title":"Neuroscience"},{"issue":"3","key":"3_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.bbalip.2010.01.001","volume":"1801","author":"RJ Wanders","year":"2010","unstructured":"Wanders RJ, Ferdinandusse S, Brites P, Kemp S (2010) Peroxisomes, lipid metabolism and lipotoxicity. Biochim Biophys Acta 1801(3):272\u2013280","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"3_CR10","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1093\/hmg\/ddn066","volume":"17","author":"S Hein","year":"2008","unstructured":"Hein S, Sch\u00f6nfeld P, Kahlert S, Reiser G (2008) Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture. Hum Mol Genet 17(12):1750\u20131761","journal-title":"Hum Mol Genet"},{"issue":"Pt B","key":"3_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.chemphyslip.2017.03.006","volume":"207","author":"M Bezine","year":"2017","unstructured":"Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, Raas Q, de S\u00e8ze J, Moreau T, El-Ayeb M, Lizard G (2017) Evidence of K(+) homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. Chem Phys Lipids 207(Pt B):135\u2013150","journal-title":"Chem Phys Lipids"},{"issue":"1","key":"3_CR12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/ana.22363","volume":"70","author":"J L\u00f3pez-Erauskin","year":"2011","unstructured":"L\u00f3pez-Erauskin J, Fourcade S, Galino J, Ruiz M, Schl\u00fcter A, Naudi A, Jove M, Portero-Otin M, Pamplona R, Ferrer I, Pujol A (2011) Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. Ann Neurol 70(1):84\u201392","journal-title":"Ann Neurol"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2019.04.016","volume":"137","author":"M Doria","year":"2019","unstructured":"Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A (2019) Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model. Free Radic Biol Med 137:46\u201358","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"3_CR14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/ana.21391","volume":"63","author":"FS Eichler","year":"2008","unstructured":"Eichler FS, Ren JQ, Cossoy M, Rietsch AM, Nagpal S, Moser AB, Frosch MP, Ransohoff RM (2008) Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy? Ann Neurol 63(6):729\u2013742","journal-title":"Ann Neurol"},{"issue":"4","key":"3_CR15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10571-015-0234-2","volume":"36","author":"M Deon","year":"2016","unstructured":"Deon M, Marchetti DP, Donida B, Wajner M, Vargas C (2016) Oxidative stress in patients with X-linked Adrenoleukodystrophy. Cell Mol Neurobiol 36(4):497\u2013512","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"3_CR16","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1007\/s12035-015-9337-5","volume":"53","author":"E Niedzielska","year":"2016","unstructured":"Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, Filip M (2016) Oxidative stress in neurodegenerative diseases. Mol Neurobiol 53(6):4094\u20134125","journal-title":"Mol Neurobiol"},{"issue":"3","key":"3_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.mam.2009.02.006","volume":"30","author":"A Vejux","year":"2009","unstructured":"Vejux A, Lizard G (2009) Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and\/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Mol Asp Med 30(3):153\u2013170","journal-title":"Mol Asp Med"},{"issue":"Pt B","key":"3_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.steroids.2015.02.003","volume":"99","author":"T Nury","year":"2015","unstructured":"Nury T, Zarrouk A, Mackrill JJ, Samadi M, Durand P, Riedinger JM, Doria M, Vejux A, Limagne E, Delmas D, Prost M, Moreau T, Hammami M, Delage-Mourroux R, O\u2019Brien NM, Lizard G (2015) Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7\u03b2-hydroxycholesterol-, or 24(S)-hydroxycholesterol: protective effects of \u03b1-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). Steroids 99(Pt B):194\u2013203","journal-title":"Steroids"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jsbmb.2016.03.037","volume":"169","author":"T Nury","year":"2017","unstructured":"Nury T, Zarrouk A, Ragot K, Debbabi M, Riedinger JM, Vejux A, Aubourg P, Lizard G (2017) 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. J Steroid Biochem Mol Biol 169:123\u2013136","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biochi.2013.09.009","volume":"98","author":"D Trompier","year":"2014","unstructured":"Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G (2014) Brain peroxisomes. Biochimie 98:102\u2013110","journal-title":"Biochimie"},{"issue":"3","key":"3_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00401-011-0836-9","volume":"122","author":"J Kou","year":"2011","unstructured":"Kou J, Kovacs GG, H\u00f6ftberger R, Kulik W, Brodde A, Forss-Petter S, H\u00f6nigschnabl S, Gleiss A, Br\u00fcgger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J (2011) Peroxisomal alterations in Alzheimer\u2019s disease. Acta Neuropathol 122(3):271\u2013283","journal-title":"Acta Neuropathol"},{"issue":"4","key":"3_CR22","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.3233\/JAD-142046","volume":"44","author":"A Zarrouk","year":"2015","unstructured":"Zarrouk A, Riedinger JM, Ahmed SH, Hammami S, Chaabane W, Debbabi M, Ben Ammou S, Rouaud O, Frih M, Lizard G, Hammami M (2015) Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. J Alzheimers Dis 44(4):1349\u20131359","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"3_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1177\/1352458513505691","volume":"20","author":"E Gray","year":"2014","unstructured":"Gray E, Rice C, Hares K, Redondo J, Kemp K, Williams M, Brown A, Scolding N, Wilkins A (2014) Reductions in neuronal peroxisomes in multiple sclerosis grey matter. Mult Scler 20(6):651\u2013659","journal-title":"Mult Scler"},{"key":"3_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0411-4","volume":"15","author":"VK Senanayake","year":"2015","unstructured":"Senanayake VK, Jin W, Mochizuki A, Chitou B, Goodenowe DB (2015) Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study. BMC Neurol 15:154","journal-title":"BMC Neurol"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.redox.2016.09.001","volume":"10","author":"G Testa","year":"2016","unstructured":"Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fant\u00f2 F, Poli G, Leonarduzzi G, Gamba P (2016) Changes in brain oxysterols at different stages of Alzheimer\u2019s disease: their involvement in neuroinflammation. Redox Biol 10:24\u201333","journal-title":"Redox Biol"},{"issue":"2","key":"3_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1194\/jlr.C400005-JLR200","volume":"46","author":"V Leoni","year":"2005","unstructured":"Leoni V, L\u00fctjohann D, Masterman T (2005) Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. J Lipid Res 46(2):191\u2013195","journal-title":"J Lipid Res"},{"issue":"7","key":"3_CR27","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1194\/jlr.M089664","volume":"60","author":"K Fellows Maxwell","year":"2019","unstructured":"Fellows Maxwell K, Bhattacharya S, Bodziak ML, Jakimovski D, Hagemeier J, Browne RW, Weinstock-Guttman B, Zivadinov R, Ramanathan M (2019) Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study. J Lipid Res 60(7):1190\u20131198","journal-title":"J Lipid Res"},{"issue":"6","key":"3_CR28","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1177\/1352458516666187","volume":"23","author":"S Mukhopadhyay","year":"2017","unstructured":"Mukhopadhyay S, Fellows K, Browne RW, Khare P, Krishnan Radhakrishnan S, Hagemeier J, Weinstock-Guttman B, Zivadinov R, Ramanathan M (2017) Interdependence of oxysterols with cholesterol profiles in multiple sclerosis. Mult Scler 23(6):792\u2013801","journal-title":"Mult Scler"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.biochi.2018.07.009","volume":"153","author":"T Nury","year":"2018","unstructured":"Nury T, Sghaier R, Zarrouk A, M\u00e9n\u00e9trier F, Uzun T, Leoni V, Caccia C, Meddeb W, Namsi A, Sassi K, Mihoubi W, Riedinger JM, Cherkaoui-Malki M, Moreau T, Vejux A, Lizard G (2018) Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: attenuation by \u03b1-tocopherol. Biochimie 153:181\u2013202","journal-title":"Biochimie"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ejmech.2013.09.028","volume":"70","author":"T Nury","year":"2013","unstructured":"Nury T, Samadi M, Zarrouk A, Riedinger JM, Lizard G (2013) Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4\u03b1- and 4\u03b2-hydroxycholesterol) and C7 (7-ketocholesterol, 7\u03b1- and 7\u03b2-hydroxycholesterol) on cells of the central nervous system. Eur J Med Chem 70:558\u2013567","journal-title":"Eur J Med Chem"},{"key":"3_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.04.020","volume":"191","author":"K Sassi","year":"2019","unstructured":"Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi-Nezhad A, Vejux A, Samadi M, Aissa-Fennira FB, Lizard G (2019) Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7\u03b2-hydroxycholesterol on glioma cells. J Steroid Biochem Mol Biol 191:105371","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"3_CR32","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.bbrc.2013.11.081","volume":"446","author":"T Nury","year":"2014","unstructured":"Nury T, Zarrouk A, Vejux A, Doria M, Riedinger JM, Delage-Mourroux R, Lizard G (2014) Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by \u03b1-tocopherol. Biochem Biophys Res Commun 446(3):714\u2013719","journal-title":"Biochem Biophys Res Commun"},{"key":"3_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105432","volume":"194","author":"R Sghaier","year":"2019","unstructured":"Sghaier R, Nury T, Leoni V, Caccia C, Pais De Barros JP, Cherif A, Vejux A, Moreau T, Limem K, Samadi M, Mackrill JJ, Masmoudi AS, Lizard G, Zarrouk A (2019) Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7\u03b2-hydroxycholesterol. J Steroid Biochem Mol Biol 194:105432","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"15","key":"3_CR34","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.2174\/1381612825666190705192902","volume":"25","author":"A Zarrouk","year":"2019","unstructured":"Zarrouk A, Martine L, Gr\u00e9goire S, Nury T, Meddeb W, Camus E, Badreddine A, Durand P, Namsi A, Yammine A, Nasser B, Mejri M, Bretillon L, Mackrill JJ, Cherkaoui-Malki M, Hammami M, Lizard G (2019) Profile of fatty acids, Tocopherols, Phytosterols and polyphenols in Mediterranean oils (Argan oils, olive oils, Milk thistle seed oils and nigella seed oil) and evaluation of their antioxidant and Cytoprotective activities. Curr Pharm Des 25(15):1791\u20131805","journal-title":"Curr Pharm Des"}],"container-title":["Advances in Experimental Medicine and Biology","Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-60204-8_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T20:40:01Z","timestamp":1610138401000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-60204-8_3"}},"subtitle":["7-ketocholesterol and 7\u03b2-hydroxycholesterol-Induced Peroxisomal Disorders and Neurodegeneration"],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030602031","9783030602048"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-60204-8_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"9 January 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}