{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:12:20Z","timestamp":1784527940314,"version":"3.55.0"},"publisher-location":"Cham","reference-count":11,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030603267","type":"print"},{"value":"9783030603274","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-60327-4_7","type":"book-chapter","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T22:38:31Z","timestamp":1601505511000},"page":"120-140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["On the Complexity of Quadratization for Polynomial Differential Equations"],"prefix":"10.1007","author":[{"given":"Mathieu","family":"Hemery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Fages","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"issue":"3","key":"7_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jco.2006.12.005","volume":"23","author":"O Bournez","year":"2007","unstructured":"Bournez, O., Campagnolo, M.L., Gra\u00e7a, D.S., Hainry, E.: Polynomial differential equations compute all real computable functions on computable compact intervals. J. Complex. 23(3), 317\u2013335 (2007)","journal-title":"J. Complex."},{"key":"7_CR2","unstructured":"Carothers, D.C., Parker, G.E., Sochacki, J.S., Warne, P.G.: Some properties of solutions to polynomial systems of differential equations. Electron. J. Diff. Eqn.2005(40), 1\u201317 (2005)"},{"key":"7_CR3","doi-asserted-by":"crossref","unstructured":"Chelliah, V., Laibe, C., Nov\u00e8re, N.: Biomodels database: a repository of mathematical models of biological processes. In: Schneider, M.V., (ed.) In Silico Systems Biology. Methods in Molecular Biology, vol. 1021, pp. 189\u2013199. Humana Press (2013)","DOI":"10.1007\/978-1-62703-450-0_10"},{"key":"7_CR4","series-title":"Natural Computing Series","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/978-3-540-88869-7_27","volume-title":"Algorithmic Bioprocesses","author":"M Cook","year":"2009","unstructured":"Cook, M., Soloveichik, D., Winfree, E., Bruck, J.: Programmability of chemical reaction networks. In: Condon, A., Harel, D., Kok, J., Salomaa, A., Winfree, E. (eds.) Algorithmic Bioprocesses. NCS, pp. 543\u2013584. Springer, Berlin, Heidelberg (2009). https:\/\/doi.org\/10.1007\/978-3-540-88869-7_27"},{"key":"7_CR5","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/978-3-319-67471-1_7","volume-title":"Computational Methods in Systems Biology","author":"F Fages","year":"2017","unstructured":"Fages, F., Le Guludec, G., Bournez, O., Pouly, A.: Strong turing completeness of continuous chemical reaction networks and compilation of mixed analog-digital programs. In: Feret, J., Koeppl, H. (eds.) CMSB 2017. LNCS, vol. 10545, pp. 108\u2013127. Springer, Cham (2017). https:\/\/doi.org\/10.1007\/978-3-319-67471-1_7"},{"issue":"1","key":"7_CR6","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.tcs.2008.04.024","volume":"403","author":"F Fages","year":"2008","unstructured":"Fages, F., Soliman, S.: Abstract interpretation and types for systems biology. Theor. Comput. Sci. 403(1), 52\u201370 (2008)","journal-title":"Theor. Comput. Sci."},{"key":"7_CR7","volume-title":"Computers and Intractability: A Guide to the Theory of NP-Completeness","author":"MR Garey","year":"1979","unstructured":"Garey, M.R., Johnson, D.S.: Computers and Intractability: A Guide to the Theory of NP-Completeness. Freeman, New York (1979)"},{"issue":"5","key":"7_CR8","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/S0885-064X(03)00034-7","volume":"19","author":"DS Gra\u00e7a","year":"2003","unstructured":"Gra\u00e7a, D.S., Costa, J.F.: Analog computers and recursive functions over the reals. J. Complex. 19(5), 644\u2013664 (2003)","journal-title":"J. Complex."},{"issue":"19","key":"7_CR9","doi-asserted-by":"publisher","first-page":"10078","DOI":"10.1073\/pnas.93.19.10078","volume":"93","author":"C-Y Huang","year":"1996","unstructured":"Huang, C.-Y., Ferrell, J.E.: Ultrasensitivity in the mitogen-activated protein kinase cascade. PNAS 93(19), 10078\u201310083 (1996)","journal-title":"PNAS"},{"issue":"3","key":"7_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0019-9958(86)80009-2","volume":"71","author":"CH Papadimitriou","year":"1986","unstructured":"Papadimitriou, C.H., Yannakakis, M.: A note on succinct representations of graphs. Inf. Control 71(3), 181\u2013185 (1986)","journal-title":"Inf. Control"},{"key":"7_CR11","unstructured":"Segel, L.A.: Modeling Dynamic Phenomena in Molecular and Cellular Biology. Cambridge University Press, New York (1984)"}],"container-title":["Lecture Notes in Computer Science","Computational Methods in Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-60327-4_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T08:23:57Z","timestamp":1619252637000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-60327-4_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030603267","9783030603274"],"references-count":11,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-60327-4_7","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"29 September 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"CMSB","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Computational Methods in Systems Biology","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Konstanz","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Germany","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2020","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"23 September 2020","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"25 September 2020","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"18","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"cmsb2020","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/cmsb2020.uni-saarland.de\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Easychair","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"30","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"22","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"0","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"73% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"3","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"2","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"The conference was held virtually due to the COVID-19 pandemic.","order":10,"name":"additional_info_on_review_process","label":"Additional Info on Review Process","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}