{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T23:52:18Z","timestamp":1743033138030,"version":"3.40.3"},"publisher-location":"Cham","reference-count":10,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030630607"},{"type":"electronic","value":"9783030630614"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-3-030-63061-4_19","type":"book-chapter","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:34:36Z","timestamp":1607546076000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integration of Single-Cell RNA-Sequencing Data into Flux Balance Cellular Automata"],"prefix":"10.1007","author":[{"given":"Davide","family":"Maspero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Angaroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Pescini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vanoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Graudenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Damiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"19_CR1","unstructured":"Di Filippo, M., et al.: Zooming-in on cancer metabolic rewiring with tissue specific constraint-based models. Comput. Biol. Chem. 62, 60\u201369 (2016)"},{"key":"19_CR2","doi-asserted-by":"crossref","unstructured":"Conde, M., do Rosario, P., Sauter, T., Pfau, T.: Constraint based modeling going multicellular. Front. Mol. Biosci. 3:3 (2016)","DOI":"10.3389\/fmolb.2016.00003"},{"key":"19_CR3","doi-asserted-by":"crossref","unstructured":"Damiani, C., et al.: Integration of single-cell RNA-seq data into population models to characterize cancer metabolism. PLoS Comput. Biol. 15(2), e1006733 (2019)","DOI":"10.1371\/journal.pcbi.1006733"},{"issue":"5","key":"19_CR4","doi-asserted-by":"publisher","first-page":"e97272","DOI":"10.1371\/journal.pone.0097272","volume":"9","author":"A Graudenzi","year":"2014","unstructured":"Graudenzi, A., Caravagna, G., De Matteis, G., Antoniotti, M.: Investigating the relation between stochastic differentiation, homeostasis and clonal expansion in intestinal crypts via multiscale modeling. PLoS ONE 9(5), e97272 (2014)","journal-title":"PLoS ONE"},{"key":"19_CR5","doi-asserted-by":"publisher","DOI":"10.1201\/b14075","volume-title":"Cellular Potts Models: Multiscale Extensions and Biological Applications","author":"M Scianna","year":"2013","unstructured":"Scianna, M., Preziosi, L.: Cellular Potts Models: Multiscale Extensions and Biological Applications. CRC Press, Boca Raton (2013)"},{"issue":"3","key":"19_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1614","volume":"28","author":"JD Orth","year":"2010","unstructured":"Orth, J.D., Thiele, I., Palsson, B.: What is flux balance analysis? Nat. Biotechnol. 28(3), 245 (2010)","journal-title":"Nat. Biotechnol."},{"key":"19_CR7","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/978-3-319-99813-8_2","volume-title":"Cellular Automata","author":"A Graudenzi","year":"2018","unstructured":"Graudenzi, A., Maspero, D., Damiani, C.: Modeling Spatio-Temporal Dynamics of Metabolic Networks with Cellular Automata and Constraint-Based Methods. In: Mauri, G., El Yacoubi, S., Dennunzio, A., Nishinari, K., Manzoni, L. (eds.) ACRI 2018. LNCS, vol. 11115, pp. 16\u201329. Springer, Cham (2018). https:\/\/doi.org\/10.1007\/978-3-319-99813-8_2"},{"key":"19_CR8","series-title":"Communications in Computer and Information Science","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-3-030-21733-4_9","volume-title":"Artificial Life and Evolutionary Computation","author":"D Maspero","year":"2019","unstructured":"Maspero, D., et al.: Synchronization Effects in a Metabolism-Driven Model of Multi-cellular System. In: Cagnoni, S., Mordonini, M., Pecori, R., Roli, A., Villani, M. (eds.) WIVACE 2018. CCIS, vol. 900, pp. 115\u2013126. Springer, Cham (2019). https:\/\/doi.org\/10.1007\/978-3-030-21733-4_9"},{"issue":"1\u20134","key":"19_CR9","first-page":"279","volume":"171","author":"D Maspero","year":"2020","unstructured":"Maspero, D., et al.: The influence of nutrients diffusion on a metabolism-driven model of a multi-cellular system. Fundam. Inform. 171(1\u20134), 279\u2013295 (2020)","journal-title":"Fundam. Inform."},{"key":"19_CR10","unstructured":"Graudenzi, A., Maspero, D., Damiani, C.: FBCA, a multiscale modeling framework combining cellular automata and flux balance analysis. J. Cell. Automata 15 (1\/2), 75\u201395 (2020)"}],"container-title":["Lecture Notes in Computer Science","Computational Intelligence Methods for Bioinformatics and Biostatistics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-63061-4_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:39:43Z","timestamp":1607546383000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-030-63061-4_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030630607","9783030630614"],"references-count":10,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-63061-4_19","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"10 December 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"CIBB","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Bergamo","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Italy","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2019","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"4 September 2019","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"6 September 2019","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"16","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"cibb2019","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/dinamico2.unibg.it\/cazzaniga\/cibb2019\/index.html","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"EasyChair","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"55","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"28","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"0","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"51% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"2,3","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"2,4","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}