{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:02:26Z","timestamp":1792184546404,"version":"4.4.0"},"publisher-location":"Cham","reference-count":38,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030648718","type":"print"},{"value":"9783030648725","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-64872-5_3","type":"book-chapter","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T08:40:06Z","timestamp":1618562406000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial"],"prefix":"10.1007","author":[{"given":"Seyed Reza","family":"Mirhafez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Azimi-Nezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Dehabeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Hariri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronika Danesh","family":"Naderan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Movahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"issue":"6","key":"3_CR1","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.mcna.2007.06.001","volume":"91","author":"MF Abdelmalek","year":"2007","unstructured":"Abdelmalek MF, Diehl AM (2007) Nonalcoholic fatty liver disease as a complication of insulin resistance. Med Clin North Am 91(6):1125\u20131149. ix","journal-title":"Med Clin North Am"},{"issue":"4","key":"3_CR2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1053\/jhep.2003.50161","volume":"37","author":"G Marchesini","year":"2003","unstructured":"Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R et al (2003) Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37(4):917\u2013923","journal-title":"Hepatology"},{"issue":"9","key":"3_CR3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/apt.12046","volume":"36","author":"Y Yilmaz","year":"2012","unstructured":"Yilmaz Y (2012) Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions? Aliment Pharmacol Ther 36(9):815\u2013823","journal-title":"Aliment Pharmacol Ther"},{"issue":"2 Suppl 1","key":"3_CR4","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1002\/hep.20973","volume":"43","author":"GC Farrell","year":"2006","unstructured":"Farrell GC, Larter CZ (2006) Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43(2 Suppl 1):S99\u2013S112","journal-title":"Hepatology"},{"issue":"1\u20132","key":"3_CR5","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.mam.2007.09.003","volume":"29","author":"F Morisco","year":"2008","unstructured":"Morisco F, Vitaglione P, Amoruso D, Russo B, Fogliano V, Caporaso N (2008) Foods and liver health. Mol Asp Med 29(1\u20132):144\u2013150","journal-title":"Mol Asp Med"},{"issue":"4","key":"3_CR6","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","volume":"114","author":"CP Day","year":"1998","unstructured":"Day CP, James OF (1998) Steatohepatitis: a tale of two \u201chits\u201d? Gastroenterology 114(4):842\u2013845","journal-title":"Gastroenterology"},{"issue":"8","key":"3_CR7","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","volume":"65","author":"E Buzzetti","year":"2016","unstructured":"Buzzetti E, Pinzani M, Tsochatzis EA (2016) The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism 65(8):1038\u20131048","journal-title":"Metabolism"},{"issue":"2","key":"3_CR8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/1756283X09359964","volume":"3","author":"B Lam","year":"2010","unstructured":"Lam B, Younossi ZM (2010) Treatment options for nonalcoholic fatty liver disease. Ther Adv Gastroenterol 3(2):121\u2013137","journal-title":"Ther Adv Gastroenterol"},{"issue":"2","key":"3_CR9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1053\/jhep.2003.50316","volume":"38","author":"M Kugelmas","year":"2003","unstructured":"Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ (2003) Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38(2):413\u2013419","journal-title":"Hepatology"},{"issue":"1","key":"3_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147985","volume":"11","author":"J Wei","year":"2016","unstructured":"Wei J, Lei GH, Fu L, Zeng C, Yang T, Peng SF (2016) Association between dietary vitamin C intake and non-alcoholic fatty liver disease: a cross-sectional study among middle-aged and older adults. PLoS One 11(1):e0147985. https:\/\/doi.org\/10.1371\/journal.pone.0147985","journal-title":"PLoS One"},{"issue":"1","key":"3_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.5607\/en.2013.22.1.23","volume":"22","author":"A Noorafshan","year":"2013","unstructured":"Noorafshan A, Asadi-Golshan R, Karbalay-Doust S, Abdollahifar MA, Rashidiani-Rashidabadi A (2013) Curcumin, the main part of turmeric, prevents learning and memory changes induced by sodium metabisulfite, a preservative agent, in rats. Exp Neurobiol 22(1):23\u201330","journal-title":"Exp Neurobiol"},{"issue":"2","key":"3_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.etap.2010.04.001","volume":"30","author":"JJ Dattani","year":"2010","unstructured":"Dattani JJ, Rajput DK, Moid N, Highland HN, George LB, Desai KR (2010) Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate. Environ Toxicol Pharmacol 30(2):103\u2013109","journal-title":"Environ Toxicol Pharmacol"},{"key":"3_CR13","doi-asserted-by":"crossref","unstructured":"Soleimani V,\u00a0Sahebkar\u00a0A,\u00a0Hosseinzadeh\u00a0H (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe\u00a0substances:\u00a0Review. Phytother Res 32(6):985\u2013995","DOI":"10.1002\/ptr.6054"},{"key":"3_CR14","doi-asserted-by":"publisher","unstructured":"Saberi-Karimian\u00a0M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B, et al (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial (2020) Complement Ther Med 49:102322. https:\/\/doi.org\/10.1016\/j.phrs.2020.104921","DOI":"10.1016\/j.phrs.2020.104921"},{"issue":"5","key":"3_CR15","first-page":"468","volume":"35","author":"C Wu","year":"2019","unstructured":"Wu C, Qiu Y, Sun X, Chen D, Wu Y, Pang Q (2019) Effects of curcumin on liver fibrosis induced by cholestasis in mice. Zhongguo Ying Yong Sheng Li Xue Za Zhi 35(5):468\u2013472","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"issue":"1","key":"3_CR16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","volume":"59","author":"H Mollazadeh","year":"2019","unstructured":"Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89\u2013101","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3_CR17","doi-asserted-by":"crossref","unstructured":"Ghandadi\u00a0M, Sahebkar A (2017)\u00a0Curcumin: An effective inhibitor of interleukin-6. Curr Pharm Des 23(6):921\u2013931","DOI":"10.2174\/1381612822666161006151605"},{"key":"3_CR18","doi-asserted-by":"crossref","unstructured":"Momtazi AA, Derosa G,\u00a0Maffioli\u00a0P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther 20(4):335\u2013345","DOI":"10.1007\/s40291-016-0202-7"},{"key":"3_CR19","doi-asserted-by":"crossref","unstructured":"Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: a review of chemistry, cellular, molecular, and preclinical features. Biofactors 43(3):331\u2013346","DOI":"10.1002\/biof.1344"},{"key":"3_CR20","doi-asserted-by":"crossref","unstructured":"Panahi Y, Ahmadi Y, Teymouri M, Johnston TP, Sahebkar A (2018) Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms. J Cell Physiol 233(1):141\u2013152","DOI":"10.1002\/jcp.25756"},{"key":"3_CR21","doi-asserted-by":"crossref","unstructured":"Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H (2009) Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur J Cancer Prev 18(5):412\u2013415","DOI":"10.1097\/CEJ.0b013e32832c389e"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"5491797","DOI":"10.1155\/2018\/5491797","volume":"2018","author":"EJ Kyung","year":"2018","unstructured":"Kyung EJ, Kim HB, Hwang ES, Lee S, Choi BK, Kim JW et al (2018) Evaluation of Hepatoprotective effect of curcumin on liver cirrhosis using a combination of biochemical analysis and magnetic resonance-based electrical conductivity imaging. Mediat Inflamm 2018:5491797\u20135491799. https:\/\/doi.org\/10.1155\/2018\/5491797","journal-title":"Mediat Inflamm"},{"issue":"4","key":"3_CR23","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1055\/s-0043-100019","volume":"67","author":"Y Panahi","year":"2017","unstructured":"Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendia LE, Sahebkar A (2017) Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res (Stuttg) 67(4):244\u2013251","journal-title":"Drug Res (Stuttg)"},{"issue":"2","key":"3_CR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00280-006-0355-x","volume":"60","author":"TH Marczylo","year":"2007","unstructured":"Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ (2007) Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60(2):171\u2013177","journal-title":"Cancer Chemother Pharmacol"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biopha.2016.11.098","volume":"85","author":"H Mirzaei","year":"2017","unstructured":"Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A (2017) Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 85:102\u2013112","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1365-2796.2011.02377.x","volume":"270","author":"A Stadlmayr","year":"2011","unstructured":"Stadlmayr A, Aigner E, Steger B, Scharinger L, Lederer D, Mayr A et al (2011) Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia. J Intern Med 270(1):41\u201349","journal-title":"J Intern Med"},{"issue":"9","key":"3_CR27","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/ptr.5659","volume":"30","author":"S Rahmani","year":"2016","unstructured":"Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar A (2016) Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res 30(9):1540\u20131548","journal-title":"Phytother Res"},{"issue":"9","key":"3_CR28","doi-asserted-by":"publisher","first-page":"15989","DOI":"10.1002\/jcb.28877","volume":"120","author":"Y Panahi","year":"2019","unstructured":"Panahi Y, Valizadegan G, Ahamdi N, Ganjali S, Majeed M, Sahebkar A (2019) Curcuminoids plus piperine improve nonalcoholic fatty liver disease: a clinical trial. J Cell Biochem 120(9):15989\u201315996","journal-title":"J Cell Biochem"},{"issue":"3","key":"3_CR29","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/FJC.0000000000000406","volume":"68","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendia LE, Sahebkar A (2016) Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: a randomized controlled trial. J Cardiovasc Pharmacol 68(3):223\u2013229","journal-title":"J Cardiovasc Pharmacol"},{"issue":"9","key":"3_CR30","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/ptr.5659","volume":"30","author":"S Rahmani","year":"2016","unstructured":"Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A et al (2016) Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res 30(9):1540\u20131548","journal-title":"Phytother Res"},{"issue":"1","key":"3_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11845-014-1226-9","volume":"185","author":"B Li","year":"2016","unstructured":"Li B, Wang L, Lu Q, Da W (2016) Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect? Ir J Med Sci 185(1):93\u2013100","journal-title":"Ir J Med Sci"},{"issue":"1","key":"3_CR32","first-page":"819","volume":"17","author":"NJ Zhao","year":"2018","unstructured":"Zhao NJ, Liao MJ, Wu JJ, Chu KX (2018) Curcumin suppresses Notch1 signaling: improvements in fatty liver and insulin resistance in rats. Mol Med Rep 17(1):819\u2013826","journal-title":"Mol Med Rep"},{"issue":"7","key":"3_CR33","doi-asserted-by":"publisher","first-page":"10060","DOI":"10.1002\/jcp.27880","volume":"234","author":"NSA Moghaddam","year":"2019","unstructured":"Moghaddam NSA, Oskouie MN, Butler AE, Petit PX, Barreto GE, Sahebkar A (2019) Hormetic effects of curcumin: what is the evidence? J Cell Physiol 234(7):10060\u201310071","journal-title":"J Cell Physiol"},{"issue":"7","key":"3_CR34","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2174\/1381612822666161010115235","volume":"23","author":"N Amel Zabihi","year":"2017","unstructured":"Amel Zabihi N, Pirro M, P Johnston T, Sahebkar A (2017) Is there a role for curcumin supplementation in the treatment of non-alcoholic fatty liver disease? The data suggest yes. Curr Pharm Des 23(7):969\u2013982","journal-title":"Curr Pharm Des"},{"issue":"28","key":"3_CR35","first-page":"9338","volume":"20","author":"W Nseir","year":"2014","unstructured":"Nseir W, Hellou E, Assy N (2014) Role of diet and lifestyle changes in nonalcoholic fatty liver disease. World J Gastroenterol 20(28):9338\u20139344","journal-title":"World J Gastroenterol"},{"issue":"46","key":"3_CR36","doi-asserted-by":"publisher","first-page":"6790","DOI":"10.3748\/wjg.v18.i46.6790","volume":"18","author":"C Finelli","year":"2012","unstructured":"Finelli C, Tarantino G (2012) Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease? World J Gastroenterol 18(46):6790\u20136800","journal-title":"World J Gastroenterol"},{"issue":"2","key":"3_CR37","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3390\/nu7020905","volume":"7","author":"W-C Huang","year":"2015","unstructured":"Huang W-C, Chiu WC, Chuang HL, Tang DW, Lee ZM, Wei L et al (2015) Effect of curcumin supplementation on physiological fatigue and physical performance in mice. Nutrients 7(2):905\u2013921","journal-title":"Nutrients"},{"issue":"3","key":"3_CR38","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41430-018-0382-9","volume":"73","author":"S Saadati","year":"2019","unstructured":"Saadati S, Hatami B, Yari Z, Shahrbaf MA, Eghtesad S, Mansour A et al (2019) The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. Eur J Clin Nutr 73(3):441\u2013449","journal-title":"Eur J Clin Nutr"}],"container-title":["Advances in Experimental Medicine and Biology","Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-64872-5_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T21:09:45Z","timestamp":1620680985000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-64872-5_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030648718","9783030648725"],"references-count":38,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-64872-5_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"17 April 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}