{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:51:37Z","timestamp":1790052697030,"version":"4.0.1"},"publisher-location":"Cham","reference-count":138,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030660130","type":"print"},{"value":"9783030660147","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-3-030-66014-7_10","type":"book-chapter","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T15:18:16Z","timestamp":1618327096000},"page":"237-264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mitochondria: The Retina\u2019s Achilles\u2019 Heel in AMD"],"prefix":"10.1007","author":[{"given":"Deborah A.","family":"Ferrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cristina","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari R.","family":"Atilano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Ash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"issue":"12","key":"10_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.tig.2003.10.012","volume":"19","author":"G Burger","year":"2003","unstructured":"Burger G, Gray MW, Lang BF (2003 Dec 1) Mitochondrial genomes: anything goes. Trends Genet 19(12):709\u2013716","journal-title":"Trends Genet"},{"issue":"5407","key":"10_CR2","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1126\/science.283.5407.1476","volume":"283","author":"MW Gray","year":"1999","unstructured":"Gray MW, Burger G, Lang BF (1999 Mar 5) Mitochondrial evolution. Science 283(5407):1476\u20131481","journal-title":"Science"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","volume":"39","author":"DC Wallace","year":"2005","unstructured":"Wallace DC (2005 Dec 15) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39:359\u2013407","journal-title":"Annu Rev Genet"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.mito.2017.02.002","volume":"36","author":"AK Toft-Kehler","year":"2017","unstructured":"Toft-Kehler AK, Skytt DM, Svare A, Lefevere E, Van Hove I, Moons L, Waagepetersen HS, Kolko M (2017 Sep 30) Mitochondrial function in M\u00fcller cells-does it matter? Mitochondrion 36:43\u201351","journal-title":"Mitochondrion"},{"issue":"R2","key":"10_CR5","doi-asserted-by":"publisher","first-page":"R139","DOI":"10.1093\/hmg\/ddx273","volume":"26","author":"V Carelli","year":"2017","unstructured":"Carelli V, La Morgia C, Ross-Cisneros FN, Sadun AA (2017 Jul 26) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26(R2):R139\u2013R150","journal-title":"Hum Mol Genet"},{"issue":"7","key":"10_CR6","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.neurobiolaging.2005.05.012","volume":"27","author":"J Feher","year":"2006","unstructured":"Feher J, Kovacs I, Artico M, Cavallotti C, Papale A, Gabrieli CB (2006 Jul 1) Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging 27(7):983\u2013993","journal-title":"Neurobiol Aging"},{"issue":"7","key":"10_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069563","volume":"8","author":"J Viiri","year":"2013","unstructured":"Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S (2013 Jul 29) Autophagy activation clears ELAVL1\/HuR-mediated accumulation of SQSTM1\/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One 8(7):e69563","journal-title":"PLoS One"},{"issue":"1","key":"10_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.453","volume":"8","author":"N Golestaneh","year":"2017","unstructured":"Golestaneh N, Chu Y, Xiao YY, Stoleru GL, Theos AC (2017 Jan) Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death Dis 8(1):e2537","journal-title":"Cell Death Dis"},{"issue":"9","key":"10_CR9","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nrm1711","volume":"6","author":"JR Yates Iii","year":"2005","unstructured":"Yates Iii JR, Gilchrist A, Howell KE, Bergeron JJ (2005 Sep) Proteomics of organelles and large cellular structures. Nat Rev Mol Cell Biol 6(9):702","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"10_CR10","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1016\/j.bbamem.2009.04.019","volume":"1788","author":"M Schlame","year":"2009","unstructured":"Schlame M, Ren M (2009 Oct 31) The role of cardiolipin in the structural organization of mitochondrial membranes. Biochim Biophys Acta (BBA) Biomembr 1788(10):2080\u20132083","journal-title":"Biochim Biophys Acta (BBA) Biomembr"},{"issue":"7","key":"10_CR11","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1167\/iovs.07-1352","volume":"49","author":"CL Nordgaard","year":"2008","unstructured":"Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA (2008 Jul 1) Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci 49(7):2848\u20132855","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10_CR12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/ICU.0b013e328349419d","volume":"22","author":"SA Schrier","year":"2011","unstructured":"Schrier SA, Falk MJ (2011 Sep) Mitochondrial disorders and the eye. Curr Opin Ophthalmol 22(5):325","journal-title":"Curr Opin Ophthalmol"},{"issue":"3","key":"10_CR13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1167\/iovs.05-0976","volume":"47","author":"CL Nordgaard","year":"2006","unstructured":"Nordgaard CL, Berg KM, Kapphahn RJ, Reilly C, Feng X, Olsen TW, Ferrington DA (2006 Mar 1) Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci 47(3):815\u2013822","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6125","key":"10_CR14","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.1230593","volume":"339","author":"HW Rhee","year":"2013","unstructured":"Rhee HW, Zou P, Udeshi ND, Martell JD, Mootha VK, Carr SA, Ting AY (2013 Mar 15) Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 339(6125):1328\u20131331","journal-title":"Science"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.redox.2017.05.015","volume":"13","author":"DA Ferrington","year":"2017","unstructured":"Ferrington DA, Ebeling MC, Kapphahn RJ et al (2017) Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration. Redox Biol 13:255\u2013265","journal-title":"Redox Biol"},{"issue":"11","key":"10_CR16","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1016\/j.bpj.2013.03.064","volume":"104","author":"MV Ivannikov","year":"2013","unstructured":"Ivannikov MV, Macleod GT (2013 Jun 4) Mitochondrial free Ca2+ levels and their effects on energy metabolism in Drosophila motor nerve terminals. Biophys J 104(11):2353\u20132361","journal-title":"Biophys J"},{"issue":"23","key":"10_CR17","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1073\/pnas.222551899","volume":"99","author":"JW Crabb","year":"2002","unstructured":"Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, Sakaguchi H, Kamei M, Hasan A, Yan L, Rayborn ME, Salomon RG (2002 Nov 12) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci 99(23):14682\u201314687","journal-title":"Proc Natl Acad Sci"},{"issue":"43","key":"10_CR18","doi-asserted-by":"publisher","first-page":"42027","DOI":"10.1074\/jbc.M305460200","volume":"278","author":"X Gu","year":"2003","unstructured":"Gu X, Meer SG, Miyagi M, Rayborn ME, Hollyfield JG, Crabb JW, Salomon RG (2003 Aug 15) Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem 278(43):42027","journal-title":"J Biol Chem"},{"issue":"2","key":"10_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nm1709","volume":"14","author":"JG Hollyfield","year":"2008","unstructured":"Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, Lu L, Ufret RL, Salomon RG, Perez VL (2008 Feb) Oxidative damage\u2013induced inflammation initiates age-related macular degeneration. Nat Med 14(2):194","journal-title":"Nat Med"},{"issue":"8","key":"10_CR20","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1167\/iovs.06-1058","volume":"48","author":"CM Ethen","year":"2007","unstructured":"Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA (2007 Aug 1) Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal. Invest Ophthalmol Vis Sci 48(8):3469\u20133479","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"44","key":"10_CR21","doi-asserted-by":"publisher","first-page":"E6000","DOI":"10.1073\/pnas.1505036112","volume":"112","author":"U Cagin","year":"2015","unstructured":"Cagin U, Duncan OF, Gatt AP, Dionne MS, Sweeney ST, Bateman JM (2015 Nov 3) Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci 112(44):E6000\u2013E6009","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"10_CR22","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/1873-3468.12890","volume":"592","author":"RJ Hunt","year":"2018","unstructured":"Hunt RJ, Bateman JM (2018 Mar) Mitochondrial retrograde signaling in the nervous system. FEBS Lett 592(5):663\u2013678","journal-title":"FEBS Lett"},{"issue":"13","key":"10_CR23","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1093\/hmg\/ddu065","volume":"23","author":"MC Kenney","year":"2014","unstructured":"Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, C\u00e1ceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD (2014a Feb 28) Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial\u2013nuclear interactions. Hum Mol Genet 23(13):3537\u20133551","journal-title":"Hum Mol Genet"},{"issue":"7","key":"10_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.348","volume":"8","author":"S Nashine","year":"2017","unstructured":"Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC (2017 Jul) Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis 8(7):e2951","journal-title":"Cell Death Dis"},{"key":"10_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.exger.2014.03.027","volume":"56","author":"TJ Nicholls","year":"2014","unstructured":"Nicholls TJ, Minczuk M (2014 Aug 1) In D-loop: 40 years of mitochondrial 7S DNA. Exp Gerontol 56:175\u2013181","journal-title":"Exp Gerontol"},{"issue":"2","key":"10_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1365-2796.2008.02066.x","volume":"265","author":"R McFarland","year":"2009","unstructured":"McFarland R, Turnbull DM (2009 Feb) Batteries not included: diagnosis and management of mitochondrial disease. J Intern Med 265(2):210\u2013228","journal-title":"J Intern Med"},{"issue":"1","key":"10_CR27","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1146\/annurev.bi.61.070192.005523","volume":"61","author":"DC Wallace","year":"1992","unstructured":"Wallace DC (1992 Jul) Diseases of the mitochondrial DNA. Annu Rev Biochem 61(1):1175\u20131212","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"10_CR28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF00763096","volume":"26","author":"DC Wallace","year":"1994","unstructured":"Wallace DC (1994 Jun 1) Mitochondrial DNA mutations in diseases of energy metabolism. J Bioenerg Biomembr 26(3):241\u2013250","journal-title":"J Bioenerg Biomembr"},{"issue":"3","key":"10_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1086\/507132","volume":"79","author":"E Bua","year":"2006","unstructured":"Bua E, Johnson J, Herbst A, Delong B, McKenzie D, Salamat S, Aiken JM (2006 Sep 1) Mitochondrial DNA\u2013deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet 79(3):469\u2013480","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10_CR30","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/(SICI)1096-8628(19990827)85:5<498::AID-AJMG13>3.0.CO;2-8","volume":"85","author":"PF Chinnery","year":"1999","unstructured":"Chinnery PF, Zwijnenburg PJ, Walker M, Howell N, Taylor RW, Lightowlers RN, Bindoff L, Turnbull DM (1999 Aug 27) Nonrandom tissue distribution of mutant mtDNA. Am J Med Genet 85(5):498\u2013501","journal-title":"Am J Med Genet"},{"issue":"1","key":"10_CR31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1086\/518901","volume":"81","author":"SE Durham","year":"2007","unstructured":"Durham SE, Samuels DC, Cree LM, Chinnery PF (2007 Jul 1) Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A\u2192G. Am J Hum Genet 81(1):189\u2013195","journal-title":"Am J Hum Genet"},{"issue":"5865","key":"10_CR32","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1126\/science.1147786","volume":"319","author":"W Fan","year":"2008","unstructured":"Fan W, Waymire KG, Narula N, Li P, Rocher C, Coskun PE, Vannan MA, Narula J, MacGregor GR, Wallace DC (2008 Feb 15) A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. Science 319(5865):958\u2013962","journal-title":"Science"},{"issue":"1","key":"10_CR33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0092-8674(90)90238-A","volume":"62","author":"EA Shoubridge","year":"1990","unstructured":"Shoubridge EA, Karpati G, Hastings KE (1990 Jul 13) Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell 62(1):43\u201349","journal-title":"Cell"},{"key":"10_CR34","volume-title":"GeneReviews (Internet)","author":"PF Chinnery","year":"2010","unstructured":"Chinnery PF (2010) Mitochondrial disorders overview. In: RA BTP, Dolan CR (eds) GeneReviews (Internet). National Library of Medicine, National Institutes of Health, Seattle, WA"},{"issue":"2","key":"10_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","volume":"30","author":"P Yu-Wai-Man","year":"2011","unstructured":"Yu-Wai-Man P, Griffiths PG, Chinnery PF (2011 Mar 1) Mitochondrial optic neuropathies\u2013disease mechanisms and therapeutic strategies. Prog Retin Eye Res 30(2):81\u2013114","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"10_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002091","volume":"3","author":"JA Canter","year":"2008","unstructured":"Canter JA, Olson LM, Spencer K, Schnetz-Boutaud N, Anderson B, Hauser MA, Schmidt S, Postel EA, Agarwal A, Pericak-Vance MA, Sternberg P Jr (2008 May 7) Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS One 3(5):e2091","journal-title":"PLoS One"},{"issue":"9","key":"10_CR37","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1001\/archopht.125.9.1235","volume":"125","author":"MM Jones","year":"2007","unstructured":"Jones MM, Manwaring N, Wang JJ, Rochtchina E, Mitchell P, Sue CM (2007 Sep 1) Mitochondrial DNA haplogroups and age-related maculopathy. Arch Ophthalmol 125(9):1235\u20131240","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10_CR38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2350-14-4","volume":"14","author":"MC Kenney","year":"2013","unstructured":"Kenney MC, Hertzog D, Chak G, Atilano SR, Khatibi N, Soe K, Nobe A, Yang E, Chwa M, Zhu F, Memarzadeh M (2013 Dec) Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study. BMC Med Genet 14(1):4","journal-title":"BMC Med Genet"},{"issue":"2","key":"10_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030874","volume":"7","author":"EE Mueller","year":"2012","unstructured":"Mueller EE, Schaier E, Brunner SM, Eder W, Mayr JA, Egger SF, Nischler C, Oberkofler H, Reitsamer HA, Patsch W, Sperl W (2012a Feb 13) Mitochondrial haplogroups and control region polymorphisms in age-related macular degeneration: a case-control study. PLoS One 7(2):e30874","journal-title":"PLoS One"},{"issue":"5","key":"10_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005508","volume":"4","author":"JP SanGiovanni","year":"2009","unstructured":"SanGiovanni JP, Arking DE, Iyengar SK, Elashoff M, Clemons TE, Reed GF, Henning AK, Sivakumaran TA, Xu X, DeWan A, Agr\u00f3n E (2009 May 12) Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration. PLoS One 4(5):e5508","journal-title":"PLoS One"},{"issue":"6","key":"10_CR41","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1167\/iovs.08-2646","volume":"50","author":"N Udar","year":"2009","unstructured":"Udar N, Atilano SR, Memarzadeh M, Boyer DS, Chwa M, Lu S, Maguen B, Langberg J, Coskun P, Wallace DC, Nesburn AB (2009 Jun 1) Mitochondrial DNA haplogroups associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 50(6):2966\u20132974","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s12192-008-0081-x","volume":"14","author":"D Bellizzi","year":"2009","unstructured":"Bellizzi D, Taverna D, D\u2019Aquila P, De Blasi S, De Benedictis G (2009 May 1) Mitochondrial DNA variability modulates mRNA and intra-mitochondrial protein levels of HSP60 and HSP75: experimental evidence from cybrid lines. Cell Stress Chaperones 14(3):265\u2013271","journal-title":"Cell Stress Chaperones"},{"issue":"10","key":"10_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046473","volume":"7","author":"A Chen","year":"2012","unstructured":"Chen A, Raule N, Chomyn A, Attardi G (2012 Oct 29) Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity. PLoS One 7(10):e46473","journal-title":"PLoS One"},{"key":"10_CR44","doi-asserted-by":"crossref","unstructured":"Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, del Carpio JC, Nesburn AB, Boyer DS, Kuppermann BD (2014b Feb 1) Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases. Biochim Biophys Acta (BBA) Mol Basis Dis 1842(2):208\u2013219","DOI":"10.1016\/j.bbadis.2013.10.016"},{"issue":"6","key":"10_CR45","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/hmg\/dds517","volume":"22","author":"D Pacheu-Grau","year":"2012","unstructured":"Pacheu-Grau D, G\u00f3mez-Dur\u00e1n A, Iglesias E, Lopez-Gallardo E, Montoya J, Ruiz-Pesini E (2012 Dec 7) Mitochondrial antibiograms in personalized medicine. Hum Mol Genet 22(6):1132\u20131139","journal-title":"Hum Mol Genet"},{"key":"10_CR46","doi-asserted-by":"publisher","unstructured":"Lin TK, Lin HY, Chen SD, Chuang YC, Chuang JH, Wang PW, Huang ST, Tiao MM, Chen JB, Liou CW (2012 Dec) The creation of cybrids harboring mitochondrial haplogroups in the Taiwanese population of ethnic Chinese background: an extensive in vitro tool for the study of mitochondrial genomic variations. Oxidative Med Cell Longev 6. https:\/\/doi.org\/10.1155\/2012\/824275","DOI":"10.1155\/2012\/824275"},{"issue":"6","key":"10_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099003","volume":"9","author":"D Malik","year":"2014","unstructured":"Malik D, Hsu T, Falatoonzadeh P, C\u00e1ceres-del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD (2014 Jun 11) Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLoS One 9(6):e99003","journal-title":"PLoS One"},{"issue":"12","key":"10_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052367","volume":"7","author":"EE Mueller","year":"2012","unstructured":"Mueller EE, Brunner SM, Mayr JA, Stanger O, Sperl W, Kofler B (2012b Dec 26) Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells. PLoS One 7(12):e52367","journal-title":"PLoS One"},{"issue":"1","key":"10_CR49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1073\/pnas.0136972100","volume":"100","author":"D Mishmar","year":"2003","unstructured":"Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, Brandon M, Easley K, Chen E, Brown MD, Sukernik RI (2003 Jan 7) Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci 100(1):171\u2013176","journal-title":"Proc Natl Acad Sci"},{"issue":"5655","key":"10_CR50","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1126\/science.1088434","volume":"303","author":"E Ruiz-Pesini","year":"2004","unstructured":"Ruiz-Pesini E, Mishmar D, Brandon M, Procaccio V, Wallace DC (2004 Jan 9) Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 303(5655):223\u2013226","journal-title":"Science"},{"key":"10_CR51","doi-asserted-by":"publisher","unstructured":"Ballinger SW Beyond retrograde and anterograde signalling: mitochondrial\u2013nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility. Biochem Soc Trans. https:\/\/doi.org\/10.1042\/BST20120227","DOI":"10.1042\/BST20120227"},{"key":"10_CR52","first-page":"543","volume":"17","author":"KK Abu-Amero","year":"2011","unstructured":"Abu-Amero KK, Cabrera VM, Larruga JM, Osman EA, Gonz\u00e1lez AM, Al-Obeidan SA (2011a) Eurasian and sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients. Mol Vis 17:543","journal-title":"Mol Vis"},{"key":"10_CR53","first-page":"1468","volume":"17","author":"KK Abu-Amero","year":"2011","unstructured":"Abu-Amero KK, Gonz\u00e1lez AM, Osman EA, Larruga JM, Cabrera VM, Al-Obeidan SA (2011b) Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients. Mol Vis 17:1468","journal-title":"Mol Vis"},{"issue":"6","key":"10_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021029","volume":"6","author":"A Achilli","year":"2011","unstructured":"Achilli A, Olivieri A, Pala M, Kashani BH, Carossa V, Perego UA, Gandini F, Santoro A, Battaglia V, Grugni V, Lancioni H (2011 Jun 9) Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One 6(6):e21029","journal-title":"PLoS One"},{"issue":"9","key":"10_CR55","doi-asserted-by":"publisher","first-page":"5589","DOI":"10.1167\/iovs.14-15149","volume":"55","author":"CB Estopinal","year":"2014","unstructured":"Estopinal CB, Chocron IM, Parks MB, Wade EA, Roberson RM, Burgess LG, Brantley MA, Samuels DC (2014 Sep 1) Mitochondrial haplogroups are associated with severity of diabetic retinopathy. Invest Ophthalmol Vis Sci 55(9):5589\u20135595","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10_CR56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2350-10-35","volume":"10","author":"B Kofler","year":"2009","unstructured":"Kofler B, Mueller EE, Eder W, Stanger O, Maier R, Weger M, Haas A, Winker R, Schmut O, Paulweber B, Iglseder B (2009 Dec) Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study. BMC Med Genet 10(1):35","journal-title":"BMC Med Genet"},{"issue":"1","key":"10_CR57","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2156-11-8","volume":"11","author":"C Wolf","year":"2010","unstructured":"Wolf C, Gramer E, M\u00fcller-Myhsok B, Pasutto F, Wissinger B, Weisschuh N (2010 Dec) Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population. BMC Genet 11(1):8","journal-title":"BMC Genet"},{"key":"10_CR58","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/978-1-4615-0067-4_30","volume":"533","author":"A Bravo-Nuevo","year":"2003","unstructured":"Bravo-Nuevo A, Williams N, Geller S, Stone J (2003) Mitochondrial deletions in normal and degenerating rat retina. Adv Exp Med Biol 533:241\u2013248","journal-title":"Adv Exp Med Biol"},{"issue":"11","key":"10_CR59","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1016\/j.neurobiolaging.2008.10.019","volume":"31","author":"AL Wang","year":"2010","unstructured":"Wang AL, Lukas TJ, Yuan M, Neufeld AH (2010 Nov 1) Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina. Neurobiol Aging 31(11):2002\u20132010","journal-title":"Neurobiol Aging"},{"issue":"11","key":"10_CR60","doi-asserted-by":"publisher","first-page":"5470","DOI":"10.1167\/iovs.10-5429","volume":"51","author":"PP Karunadharma","year":"2010","unstructured":"Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA (2010 Nov 1) Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest Ophthalmol Vis Sci 51(11):5470\u20135479","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10_CR61","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.exger.2008.03.004","volume":"43","author":"C Meissner","year":"2008","unstructured":"Meissner C, Bruse P, Mohamed SA, Schulz A, Warnk H, Storm T, Oehmichen M (2008 Jul 1) The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: a useful biomarker or more? Exp Gerontol 43(7):645\u2013652","journal-title":"Exp Gerontol"},{"issue":"8","key":"10_CR62","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1167\/iovs.09-4778","volume":"51","author":"MC Kenney","year":"2010","unstructured":"Kenney MC, Atilano SR, Boyer D, Chwa M, Chak G, Chinichian S, Coskun P, Wallace DC, Nesburn AB, Udar NS (2010 Aug 1) Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients. Invest Ophthalmol Vis Sci 51(8):4289\u20134297","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10_CR63","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0014-4835(03)00023-X","volume":"76","author":"FQ Liang","year":"2003","unstructured":"Liang FQ, Godley BF (2003 Apr 1) Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res 76(4):397\u2013403","journal-title":"Exp Eye Res"},{"issue":"1-3","key":"10_CR64","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.brainresbull.2006.09.007","volume":"71","author":"TC Nag","year":"2006","unstructured":"Nag TC, Wadhwa S, Chaudhury S (2006 Dec 11) The occurrence of cone inclusions in the ageing human retina and their possible effect upon vision: an electron microscope study. Brain Res Bull 71(1-3):224\u2013232","journal-title":"Brain Res Bull"},{"issue":"18","key":"10_CR65","doi-asserted-by":"publisher","first-page":"7304","DOI":"10.1523\/JNEUROSCI.0190-15.2015","volume":"35","author":"MR Terluk","year":"2015","unstructured":"Terluk MR, Kapphahn RJ, Soukup LM, Gong H, Gallardo C, Montezuma SR, Ferrington DA (2015 May 6) Investigating mitochondria as a target for treating age-related macular degeneration. J Neurosci 35(18):7304\u20137311","journal-title":"J Neurosci"},{"issue":"6","key":"10_CR66","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1167\/iovs.10-6163","volume":"52","author":"H Lin","year":"2011","unstructured":"Lin H, Xu H, Liang FQ, Liang H, Gupta P, Havey AN, Boulton ME, Godley BF (2011 May 1) Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration. Invest Ophthalmol Vis Sci 52(6):3521\u20133529","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159828","volume":"11","author":"S Nashine","year":"2016","unstructured":"Nashine S, Chwa M, Kazemian M, Thaker K, Lu S, Nesburn A, Kuppermann BD, Kenney MC (2016 Aug 3) Differential expression of complement markers in normal and AMD transmitochondrial cybrids. PLoS One 11(8):e0159828","journal-title":"PLoS One"},{"issue":"4","key":"10_CR68","doi-asserted-by":"publisher","first-page":"796","DOI":"10.18632\/aging.100943","volume":"8","author":"LJ Cobb","year":"2016","unstructured":"Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J (2016 Apr) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY) 8(4):796","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10_CR69","doi-asserted-by":"publisher","first-page":"AMD41","DOI":"10.1167\/iovs.18-24289","volume":"59","author":"CR Fisher","year":"2018","unstructured":"Fisher CR, Ferrington DA (2018 Mar 20) Perspective on AMD pathobiology: a bioenergetic crisis in the RPE. Invest Ophthalmol Vis Sci 59(4):AMD41\u2013AMD47","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR70","first-page":"57","volume":"189","author":"HA Krebs","year":"1927","unstructured":"Krebs HA (1927) On the metabolism of the retina. Biochem Z 189:57\u201359","journal-title":"Biochem Z"},{"key":"10_CR71","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/BF01504608","volume":"12","author":"O Warburg","year":"1924","unstructured":"Warburg O (1924) \u00dcber den Stoffwechsel der Carzinomzelle. Naturwissenschaften 12:1131. https:\/\/doi.org\/10.1007\/BF01504608","journal-title":"Naturwissenschaften"},{"key":"10_CR72","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25946","volume":"6","author":"Y Chinchore","year":"2017","unstructured":"Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL (2017 Jun 9) Glycolytic reliance promotes anabolism in photoreceptors. Elife 6:e25946","journal-title":"Elife"},{"issue":"3","key":"10_CR73","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1471-4159.1960.tb13363.x","volume":"5","author":"LH Cohen","year":"1960","unstructured":"Cohen LH, Noell WK (1960 May) Glucose catabolism of rabbit retina before and after development of visual function. J Neurochem 5(3):253\u2013276","journal-title":"J Neurochem"},{"issue":"9","key":"10_CR74","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1074\/jbc.M115.698985","volume":"291","author":"J Du","year":"2016","unstructured":"Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satr\u00fastegui J, Kanow M (2016a Feb 26) Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. J Biol Chem 291(9):4698\u20134710","journal-title":"J Biol Chem"},{"issue":"7","key":"10_CR75","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/ceo.12952","volume":"45","author":"DS Narayan","year":"2017","unstructured":"Narayan DS, Chidlow G, Wood JP, Casson RJ (2017 Sep) Glucose metabolism in mammalian photoreceptor inner and outer segments. Clin Exp Ophthalmol 45(7):730\u2013741","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"10_CR76","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1365-201X.1997.00131.x","volume":"160","author":"L Wang","year":"1997","unstructured":"Wang L, T\u00f6rnquist P, Bill A (1997 Apr) Glucose metabolism in pig outer retina in light and darkness. Acta Physiol Scand 160(1):75\u201381","journal-title":"Acta Physiol Scand"},{"issue":"6","key":"10_CR77","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1085\/jgp.77.6.667","volume":"77","author":"BS Winkler","year":"1981","unstructured":"Winkler BS (1981 Jun 1) Glycolytic and oxidative metabolism in relation to retinal function. J Gen Physiol 77(6):667\u2013692","journal-title":"J Gen Physiol"},{"issue":"6","key":"10_CR78","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1042\/BST20150153","volume":"43","author":"S Schuster","year":"2015","unstructured":"Schuster S, Boley D, M\u00f6ller P, Stark H, Kaleta C (2015 Dec 1) Mathematical models for explaining the Warburg effect: a review focussed on ATP and biomass production. Biochem Soc Trans 43(6):1187\u20131194","journal-title":"Biochem Soc Trans"},{"issue":"10","key":"10_CR79","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1016\/S0021-9258(19)61742-4","volume":"236","author":"OH Lowry","year":"1961","unstructured":"Lowry OH, Roberts NR, Schulz DW, Clow JE, Clark JR (1961 Oct 1) Quantitative histochemistry of retina II. Enzymes of glucose metabolism. J Biol Chem 236(10):2813\u20132820","journal-title":"J Biol Chem"},{"issue":"9","key":"10_CR80","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1016\/j.celrep.2018.04.111","volume":"23","author":"L Petit","year":"2018","unstructured":"Petit L, Ma S, Cipi J, Cheng SY, Zieger M, Hay N, Punzo C (2018 May 29) Aerobic glycolysis is essential for normal rod function and controls secondary cone death in retinitis pigmentosa. Cell Rep 23(9):2629\u20132642","journal-title":"Cell Rep"},{"issue":"6","key":"10_CR81","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.mito.2013.08.005","volume":"13","author":"A Rajala","year":"2013","unstructured":"Rajala A, Gupta VK, Anderson RE, Rajala RV (2013 Nov 30) Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion 13(6):566\u2013576","journal-title":"Mitochondrion"},{"issue":"1","key":"10_CR82","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1167\/iovs.15-17962","volume":"57","author":"RJ Casson","year":"2016","unstructured":"Casson RJ, Wood JP, Han G, Kittipassorn T, Peet DJ, Chidlow G (2016 Jan 1) M-type pyruvate kinase isoforms and lactate dehydrogenase A in the mammalian retina: metabolic implications. Invest Ophthalmol Vis Sci 57(1):66\u201380","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"43","key":"10_CR83","doi-asserted-by":"publisher","first-page":"15579","DOI":"10.1073\/pnas.1412441111","volume":"111","author":"KJ Lindsay","year":"2014","unstructured":"Lindsay KJ, Du J, Sloat SR, Contreras L, Linton JD, Turner SJ, Sadilek M, Satr\u00fastegui J, Hurley JB (2014 Oct 28) Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina. Proc Natl Acad Sci 111(43):15579\u201315584","journal-title":"Proc Natl Acad Sci"},{"key":"10_CR84","doi-asserted-by":"publisher","first-page":"37727","DOI":"10.1038\/srep37727","volume":"6","author":"RV Rajala","year":"2016","unstructured":"Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE (2016 Nov 24) The Warburg effect mediator pyruvate kinase M2 expression and regulation in the retina. Sci Rep 6:37727","journal-title":"Sci Rep"},{"key":"10_CR85","first-page":"847","volume":"22","author":"EM Rueda","year":"2016","unstructured":"Rueda EM, Johnson JE Jr, Giddabasappa A, Swaroop A, Brooks MJ, Sigel I, Chaney SY, Fox DA (2016) The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. Mol Vis 22:847","journal-title":"Mol Vis"},{"key":"10_CR86","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28899","volume":"6","author":"MA Kanow","year":"2017","unstructured":"Kanow MA, Giarmarco MM, Jankowski CS, Tsantilas K, Engel AL, Du J, Linton JD, Farnsworth CC, Sloat SR, Rountree A, Sweet IR (2017 Sep 13) Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye. Elife 6:e28899","journal-title":"Elife"},{"issue":"2","key":"10_CR87","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.celrep.2016.03.022","volume":"15","author":"W Wang","year":"2016","unstructured":"Wang W, Lee SJ, Scott PA, Lu X, Emery D, Liu Y, Ezashi T, Roberts MR, Ross JW, Kaplan HJ, Dean DC (2016 Apr 12) Two-step reactivation of dormant cones in retinitis pigmentosa. Cell Rep 15(2):372\u2013385","journal-title":"Cell Rep"},{"key":"10_CR88","first-page":"201311193","volume":"9","author":"J Du","year":"2013","unstructured":"Du J, Cleghorn W, Contreras L, Linton JD, Chan GC, Chertov AO, Saheki T, Govindaraju V, Sadilek M, Satr\u00fastegui J, Hurley JB (2013 Oct) Cytosolic reducing power preserves glutamate in retina. Proc Natl Acad Sci 9:201311193","journal-title":"Proc Natl Acad Sci"},{"issue":"30","key":"10_CR89","doi-asserted-by":"publisher","first-page":"20570","DOI":"10.1074\/jbc.M114.565457","volume":"289","author":"J Adijanto","year":"2014","unstructured":"Adijanto J, Du J, Moffat C, Seifert EL, Hurley JB, Philp NJ (2014 Jul 25) The retinal pigment epithelium utilizes fatty acids for ketogenesis implications for metabolic coupling with the outer retina. J Biol Chem 289(30):20570\u201320582","journal-title":"J Biol Chem"},{"key":"10_CR90","doi-asserted-by":"publisher","first-page":"8038","DOI":"10.1074\/jbc.M116.770784","volume":"292","author":"J Reyes-Reveles","year":"2017","unstructured":"Reyes-Reveles J, Dhingra A, Alexander D, Bragin A, Philp NJ, Boesze-Battaglia K (2017 Mar 16) Phagocytosis dependent ketogenesis in retinal pigment epithelium. J Biol Chem 292:8038","journal-title":"J Biol Chem"},{"issue":"4","key":"10_CR91","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1001\/archopht.121.4.547","volume":"121","author":"ND Wangsa-Wirawan","year":"2003","unstructured":"Wangsa-Wirawan ND, Linsenmeier RA (2003 Apr 1) Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol 121(4):547\u2013557","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10_CR92","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1350-9462(00)00027-6","volume":"20","author":"DY Yu","year":"2001","unstructured":"Yu DY, Cringle SJ (2001 Mar 1) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res 20(2):175\u2013208","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"10_CR93","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1017\/S0952523802194028","volume":"19","author":"QV Hoang","year":"2002","unstructured":"Hoang QV, Linsenmeier RA, Chung CK, Curcio CA (2002 Jul) Photoreceptor inner segments in monkey and human retina: mitochondrial density, optics, and regional variation. Vis Neurosci 19(4):395\u2013407","journal-title":"Vis Neurosci"},{"key":"10_CR94","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2007.10.083","volume":"1189","author":"J Stone","year":"2008","unstructured":"Stone J, van Driel D, Valter K, Rees S, Provis J (2008 Jan 16) The locations of mitochondria in mammalian photoreceptors: relation to retinal vasculature. Brain Res 1189:58\u201369","journal-title":"Brain Res"},{"issue":"1","key":"10_CR95","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0034-5288(18)31228-1","volume":"47","author":"L De Schaepdrijver","year":"1989","unstructured":"De Schaepdrijver L, Simoens P, Lauwers H, De Geest JP (1989 Jul 1) Retinal vascular patterns in domestic animals. Res Vet Sci 47(1):34\u201342","journal-title":"Res Vet Sci"},{"issue":"19","key":"10_CR96","doi-asserted-by":"publisher","first-page":"8599","DOI":"10.1073\/pnas.1002471107","volume":"107","author":"JD Linton","year":"2010","unstructured":"Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R (2010 May 11) Flow of energy in the outer retina in darkness and in light. Proc Natl Acad Sci 107(19):8599\u20138604","journal-title":"Proc Natl Acad Sci"},{"key":"10_CR97","first-page":"2689","volume":"23","author":"MM Giarmarco","year":"2017","unstructured":"Giarmarco MM, Cleghorn WM, Sloat SR, Hurley JB, Brockerhoff SE (2017 Jan) Mitochondria maintain distinct Ca2+ pools in cone photoreceptors. J Neurosci 23:2689\u20132616","journal-title":"J Neurosci"},{"issue":"1","key":"10_CR98","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.ph.52.030190.002315","volume":"52","author":"RM Denton","year":"1990","unstructured":"Denton RM, McCormack JG (1990 Mar) Ca2+ as a second messenger within mitochondria of the heart and other tissues. Annu Rev Physiol 52(1):451\u2013466","journal-title":"Annu Rev Physiol"},{"issue":"13","key":"10_CR99","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1167\/iovs.15-17901","volume":"56","author":"K Kooragayala","year":"2015","unstructured":"Kooragayala K, Gotoh N, Cogliati T, Nellissery J, Kaden TR, French S, Balaban R, Li W, Covian R, Swaroop A (2015 Dec 1) Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria. Invest Ophthalmol Vis Sci 56(13):8428\u20138436","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10_CR100","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12915-017-0451-x","volume":"15","author":"EA Pearsall","year":"2017","unstructured":"Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z (2017 Dec) PPAR\u03b1 is essential for retinal lipid metabolism and neuronal survival. BMC Biol 15(1):113","journal-title":"BMC Biol"},{"issue":"5","key":"10_CR101","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.mito.2004.07.020","volume":"4","author":"GA Perkins","year":"2004","unstructured":"Perkins GA, Ellisman MH, Fox DA (2004 Sep 30) The structure\u2013function correlates of mammalian rod and cone photoreceptor mitochondria: observations and unanswered questions. Mitochondrion 4(5):695\u2013703","journal-title":"Mitochondrion"},{"issue":"3","key":"10_CR102","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/IAE.0000000000001946","volume":"38","author":"KM Litts","year":"2018","unstructured":"Litts KM, Zhang Y, Freund KB, Curcio CA (2018 Mar 1) Optical coherence tomography and histology of age-related macular degeneration support mitochondria as reflectivity sources. Retina 38(3):445\u2013461","journal-title":"Retina"},{"issue":"1","key":"10_CR103","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1471-4159.2006.04349.x","volume":"101","author":"Y Xu","year":"2007","unstructured":"Xu Y, Ola MS, Berkich DA, Gardner TW, Barber AJ, Palmieri F, Hutson SM, LaNoue KF (2007 Apr) Energy sources for glutamate neurotransmission in the retina: absence of the aspartate\/glutamate carrier produces reliance on glycolysis in glia. J Neurochem 101(1):120\u2013131","journal-title":"J Neurochem"},{"key":"10_CR104","first-page":"106","volume":"59","author":"T Kuwabara","year":"1961","unstructured":"Kuwabara T, Cogan DG (1961) Retinal glycogen. Trans Am Ophthalmol Soc 59:106","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"2","key":"10_CR105","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0014-4835(90)90233-K","volume":"50","author":"SS Goldman","year":"1990","unstructured":"Goldman SS (1990 Feb 1) Evidence that the gluconeogenic pathway is confined to an enriched M\u00fcller cell fraction derived from the amphibian retina. Exp Eye Res 50(2):213\u2013218","journal-title":"Exp Eye Res"},{"issue":"3","key":"10_CR106","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","volume":"85","author":"O Strauss","year":"2005","unstructured":"Strauss O (2005 Jul) The retinal pigment epithelium in visual function. Physiol Rev 85(3):845\u2013881","journal-title":"Physiol Rev"},{"key":"10_CR107","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1242\/jcs.072389","volume":"123","author":"SM Gospe","year":"2010","unstructured":"Gospe SM, Baker SA, Arshavsky VY (2010 Jan 1) Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. J Cell Sci 123:3639","journal-title":"J Cell Sci"},{"issue":"2","key":"10_CR108","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/s41419-018-0296-4","volume":"9","author":"A Rajala","year":"2018","unstructured":"Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CS, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RV (2018 Feb 14) Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis 9(2):240","journal-title":"Cell Death Dis"},{"issue":"45","key":"10_CR109","doi-asserted-by":"publisher","first-page":"16245","DOI":"10.1073\/pnas.0504419102","volume":"102","author":"AA Deora","year":"2005","unstructured":"Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E (2005 Nov 8) Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci 102(45):16245\u201316250","journal-title":"Proc Natl Acad Sci"},{"key":"10_CR110","first-page":"433","volume-title":"Progress in molecular biology and translational science","author":"CB Wright","year":"2015","unstructured":"Wright CB, Redmond TM, Nickerson JM (2015 Jan 1) A history of the classical visual cycle. In: Progress in molecular biology and translational science, vol 134. Academic Press, New York, pp 433\u2013448"},{"issue":"31","key":"10_CR111","doi-asserted-by":"publisher","first-page":"12895","DOI":"10.1074\/jbc.M117.788422","volume":"292","author":"JR Chao","year":"2017","unstructured":"Chao JR, Knight K, Engel AL, Jankowski C, Wang Y, Manson MA, Gu H, Djukovic D, Raftery D, Hurley JB, Du J (2017 Aug 4) Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side. J Biol Chem 292(31):12895\u201312905","journal-title":"J Biol Chem"},{"issue":"51","key":"10_CR112","doi-asserted-by":"publisher","first-page":"14710","DOI":"10.1073\/pnas.1604572113","volume":"113","author":"J Du","year":"2016","unstructured":"Du J, Yanagida A, Knight K, Engel AL, Vo AH, Jankowski C, Sadilek M, Manson MA, Ramakrishnan A, Hurley JB, Chao JR (2016b Dec 20) Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium. Proc Natl Acad Sci 113(51):14710\u201314715","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"10_CR113","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.exer.2005.10.034","volume":"83","author":"P deS Senanayake","year":"2006","unstructured":"deS Senanayake P, Calabro A, Hu JG, Bonilha VL, Darr A, Bok D, Hollyfield JG (2006 Aug 1) Glucose utilization by the retinal pigment epithelium: evidence for rapid uptake and storage in glycogen, followed by glycogen utilization. Exp Eye Res 83(2):235\u2013246","journal-title":"Exp Eye Res"},{"issue":"8","key":"10_CR114","first-page":"2015","volume":"41","author":"CA Curcio","year":"2000","unstructured":"Curcio CA, Owsley C, Jackson GR (2000 Jul 1) Spare the rods, save the cones in aging and age-related maculopathy. Invest Ophthalmol Vis Sci 41(8):2015\u20132018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"19","key":"10_CR115","doi-asserted-by":"publisher","first-page":"5415","DOI":"10.1113\/JP272556","volume":"594","author":"NT Ingram","year":"2016","unstructured":"Ingram NT, Sampath AP, Fain GL (2016 Oct 1) Why are rods more sensitive than cones? J Physiol 594(19):5415\u20135426","journal-title":"J Physiol"},{"issue":"1","key":"10_CR116","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nn.2234","volume":"12","author":"C Punzo","year":"2009","unstructured":"Punzo C, Kornacker K, Cepko CL (2009 Jan) Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44","journal-title":"Nat Neurosci"},{"issue":"4","key":"10_CR117","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.cell.2015.03.023","volume":"161","author":"N A\u00eft-Ali","year":"2015","unstructured":"A\u00eft-Ali N, Fridlich R, Millet-Puel G, Cl\u00e9rin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A (2015 May 7) Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell 161(4):817\u2013832","journal-title":"Cell"},{"issue":"20","key":"10_CR118","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","volume":"74","author":"T L\u00e9veillard","year":"2017","unstructured":"L\u00e9veillard T, Sahel JA (2017 Oct 1) Metabolic and redox signaling in the retina. Cell Mol Life Sci 74(20):3649\u20133665","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10_CR119","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1172\/JCI44303","volume":"121","author":"C Zhao","year":"2011","unstructured":"Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM (2011 Jan 4) mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest 121(1):369\u2013383","journal-title":"J Clin Invest"},{"key":"10_CR120","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.14319","volume":"5","author":"T Kurihara","year":"2016","unstructured":"Kurihara T, Westenskow PD, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander MS, Paris LP, Chew E (2016 Mar 15) Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. Elife 5:e14319","journal-title":"Elife"},{"issue":"12","key":"10_CR121","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1172\/JCI86905","volume":"126","author":"L Zhang","year":"2016","unstructured":"Zhang L, Du J, Justus S, Hsu CW, Bonet-Ponce L, Wu WH, Tsai YT, Wu WP, Jia Y, Duong JK, Mahajan VB (2016 Dec 1) Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest 126(12):4659\u20134673","journal-title":"J Clin Invest"},{"issue":"7","key":"10_CR122","first-page":"1236","volume":"37","author":"CA Curcio","year":"1996","unstructured":"Curcio CA, Medeiros NE, Millican CL (1996 Jun 1) Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci 37(7):1236\u20131249","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"10_CR123","first-page":"3278","volume":"34","author":"CA Curcio","year":"1993","unstructured":"Curcio CA, Millican CL, Allen KA, Kalina RE (1993 Nov 1) Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci 34(12):3278\u20133296","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10_CR124","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.902920402","volume":"292","author":"CA Curcio","year":"1990","unstructured":"Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990 Feb 22) Human photoreceptor topography. J Comp Neurol 292(4):497\u2013523","journal-title":"J Comp Neurol"},{"issue":"1","key":"10_CR125","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/cne.902880113","volume":"288","author":"O Packer","year":"1989","unstructured":"Packer O, Hendrickson AE, Curcio CA (1989 Oct 1) Photoreceptor topography of the retina in the adult pigtail macaque (Macaca nemestrina). J Comp Neurol 288(1):165\u2013183","journal-title":"J Comp Neurol"},{"key":"10_CR126","unstructured":"Daiger SP, Sullivan LS, Bowne SJ, Rossiter BJ RetNet: Retinal Information Network, 1996. Data services and software for identifying genes and mutations causing retinal degeneration. http:\/\/www.sph.uth.tmc.edu\/RetNet\/ [updated Dec 08 2014]"},{"issue":"8","key":"10_CR127","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.str.2014.06.009","volume":"22","author":"MF Calabrese","year":"2014","unstructured":"Calabrese MF, Rajamohan F, Harris MS, Caspers NL, Magyar R, Withka JM, Wang H, Borzilleri KA, Sahasrabudhe PV, Hoth LR, Geoghegan KF (2014 Aug 5) Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure 22(8):1161\u20131172","journal-title":"Structure"},{"issue":"9","key":"10_CR128","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1038\/nn.3772","volume":"17","author":"MA Samuel","year":"2014","unstructured":"Samuel MA, Voinescu PE, Lilley BN, De Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR (2014 Sep) LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci 17(9):1190","journal-title":"Nat Neurosci"},{"key":"10_CR129","doi-asserted-by":"publisher","first-page":"10475","DOI":"10.1073\/pnas.1802724115","volume":"115","author":"L Xu","year":"2018","unstructured":"Xu L, Kong L, Wang J, Ash JD (2018 Oct 9) Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium. PNAS 115:10475\u201310480","journal-title":"PNAS"},{"issue":"4","key":"10_CR130","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1172\/JCI79766","volume":"125","author":"A Venkatesh","year":"2015","unstructured":"Venkatesh A, Ma S, Le YZ, Hall MN, R\u00fcegg MA, Punzo C (2015 Apr 1) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest 125(4):1446\u20131458. https:\/\/doi.org\/10.1172\/JCI79766","journal-title":"J Clin Invest"},{"key":"10_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2015.04.006","volume":"135","author":"S Ma","year":"2015","unstructured":"Ma S, Venkatesh A, Langellotto F, Le YZ, Hall MN, R\u00fcegg MA, Punzo C (2015 Jun 1) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Exp Eye Res 135:1\u20133. https:\/\/doi.org\/10.1016\/j.exer.2015.04.006","journal-title":"Exp Eye Res"},{"issue":"4","key":"10_CR132","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1167\/iovs.08-2656","volume":"50","author":"J Qu","year":"2009","unstructured":"Qu J, Kaufman Y, Washington I (2009 Apr 1) Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci 50(4):1814\u20131818. https:\/\/doi.org\/10.1167\/iovs.08-2656","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR133","doi-asserted-by":"crossref","unstructured":"Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Gabrieli CB (2005) Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. 219(3):154\u2013166","DOI":"10.1159\/000085248"},{"issue":"2","key":"10_CR134","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1167\/iovs.15-17703","volume":"57","author":"CJ Ildefonso","year":"2016","unstructured":"Ildefonso CJ, Jaime H, Brown EE, Iwata RL, Ahmed CM, Massengill MT, Biswal MR, Boye SE, Hauswirth WW, Ash JD, Li Q (2016 Feb 1) Targeting the Nrf2 signaling pathway in the retina with a gene-delivered secretable and cell-penetrating peptide. Invest Ophthalmol Vis Sci 57(2):372\u2013386","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10_CR135","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.ymthe.2016.12.016","volume":"25","author":"KJ Liang","year":"2017","unstructured":"Liang KJ, Woodard KT, Weaver MA, Gaylor JP, Weiss ER, Samulski RJ (2017 Mar 1) AAV-Nrf2 promotes protection and recovery in animal models of oxidative stress. Mol Ther 25(3):765\u2013779","journal-title":"Mol Ther"},{"issue":"29","key":"10_CR136","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.1073\/pnas.0705070104","volume":"104","author":"S J\u00e4ger","year":"2007","unstructured":"J\u00e4ger S, Handschin C, Pierre JS, Spiegelman BM (2007 Jul 17) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1\u03b1. Proc Natl Acad Sci 104(29):12017\u201312022","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10_CR137","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1167\/iovs.15-17758","volume":"57","author":"J Iacovelli","year":"2016","unstructured":"Iacovelli J, Rowe GC, Khadka A, Diaz-Aguilar D, Spencer C, Arany Z, Saint-Geniez M (2016 Mar 1) PGC-1\u03b1 induces human RPE oxidative metabolism and antioxidant capacity. Invest Ophthalmol Vis Sci 57(3):1038\u20131051. https:\/\/doi.org\/10.1167\/iovs.15-17758","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR138","doi-asserted-by":"publisher","unstructured":"Zhang M, Chu Y, Mowery J, Konkel B, Galli S, Theos AC, Golestaneh N (2018 Jan 1) PGC-1\u03b1 repression and high fat diet induce age-related macular degeneration-like phenotypes in mice. Dis Models Mech. https:\/\/doi.org\/10.1242\/dmm.032698","DOI":"10.1242\/dmm.032698"}],"container-title":["Advances in Experimental Medicine and Biology","Age-related Macular Degeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-030-66014-7_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T15:24:04Z","timestamp":1618327444000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-030-66014-7_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030660130","9783030660147"],"references-count":138,"URL":"https:\/\/doi.org\/10.1007\/978-3-030-66014-7_10","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"14 April 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}